Genomic heterogeneity of hepatitis B virus in a 54-year-old woman who contracted the infection through materno-fetal transmission. NLM AIDSLINE Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

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Genomic heterogeneity of hepatitis B virus in a 54-year-old woman who contracted the infection through materno-fetal transmission.

Jpn J Exp Med. 1987 Aug;57(4):231-6. Unique Identifier : AIDSLINE MED/88119689
Okamoto H; Imai M; Kametani M; Nakamura T; Mayumi M; Immunology Division, Jichi Medical School, Tochigi-ken, Japan.

Abstract: From the plasma of a 54-year-old woman, who acquired the persistent carrier state of hepatitis B virus through materno-fetal transmission, 49 clones of viral genomes were propagated. They did not reveal any differences in the size and number of cleavage products with any of 11 restriction endonucleases. Randomly selected 5 clones were classified into 3 groups by the variation at 4 positions in the nucleotide sequence of the envelope and core genes. The complete nucleotide sequences were determined for 3 of them, each representing a group, and they all had a genomic length of 3215 nucleotides. Variation was found in from 5 to 11 nucleotides. Assuming the infection with the common ancestor virus at birth, hepatitis B virus genomes in her plasma were estimated to have evolved at a rate from 1.4 to 3.2 x 10(-5) nucleotide substitutions per site per year. This value is 10(4)-fold greater than DNA genomes, 10(2)-fold less than human immunodeficiency virus but in the same order as most RNA viruses including certain retroviruses.
Keywords: Base Sequence Case Report Female Hepatitis B/*MICROBIOLOGY/TRANSMISSION Hepatitis B Virus/*GENETICS Human Maternal-Fetal Exchange Middle Age Molecular Sequence Data Mutation Pregnancy Time Factors JOURNAL ARTICLE

KWDbasesequencecasereportfemalehepatitisb/KWDmicrobiology/transmissionhepatitisbvirus/KWDgeneticshumanmaternal-fetalexchangemiddleagemolecularsequencedatamutationpregnancytimefactorsjournalarticle
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M8850439

Copyright © 1988 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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