Services [S.l.] : DHHS/PHS/CDC/CPS/Technical Information Services, [1987] 21 p Unique Identifier : AIDSLINE CAT/8803399
Contains the names, addresses, and phone numbers of organizations which produce and/or distribute informational materials on acquired immunodeficiency syndrome (AIDS). Also lists selected publications, list of AIDS Health Educational/Risk Reduction (HE/RR) Program Coordinators, and key staff in pertinent state health
Progress in Immunology VI. Sixth International Congress of Immunology. Cinader B, Miller RG, eds. New York, Academic Press, p. 538-47, 1986.. Unique Identifier : AIDSLINE ICDB/88640032
Robert-Guroff M; Gallo RC; Lab. of Tumor Cell Biology, NCI, Bethesda, MD 20205
The discovery and characteristics of human T lymphotropic viruses (types I, II, and III), genetics of HTLV-III, mechanisms of cell pathogenicity of HTLV-III, and the challenges of development of a vaccine against HTLV-III infection are reviewed. Immune suppression can occur with several retrovirus infections. This fea
Cancer Treat Res; 36:205-32 1987. Unique Identifier : AIDSLINE ICDB/88640254
Chachoua A; Green M; NYU Medical Center, 550 First Ave., New York, NY 10016
The recent discovery of a retrovirus termed HIV (human immunodeficiency virus), HTLV-III (human T-lymphotropic virus type III), or LAV (lymphadenopathy-associated virus) and the consequent development of an antibody assay have clearly implicated this virus as the etiologic agent of the acquired immune deficiency syndr
Abstracts of papers concerned with approaches to prevention and therapy of diseases involving human retroviruses, of cancer, and of AIDS, presented in nine plenary and three poster sessions at a UCLA Symposium, held on April 1-6, 1987, in Keystone, CO, are published in this journal. Headings for the plenary sessions a
Lectures and Symposia of the 14th International Cancer Congress (UICC). Volume 2. Lapis K, Eckhardt S, eds. Budapest, Akademiai Kiado, 352 p., 1987.. Unique Identifier : AIDSLINE ICDB/88641448
Anonymous; No affiliation given
This volume is one of a series of 13 which contain selected papers presented at the 14th International Cancer Congress held in Budapest, Hungary , from August 21-27, 1986, sponsored by the UICC (International Union Against Cancer). T
Med Staff Couns. 1988 Winter;2(1):53-8. Unique Identifier : AIDSLINE AHA/88121440
Connor GW
The grim statistics of the AIDS crisis have triggered a sweeping public policy debate over issues that directly affect the physician, including whether testing for AIDS should be mandatory, whether the physician has a duty to disclose known risks to an endangered third party or keep such information confidential, and
Kang YH; Yaffe L; Grimley PM; Department of Pathology, Uniformed Services University of the; Health Sciences, Bethesda, MD.
Reactions of mouse monoclonal antibodies with T-cell, B-cell, or NK cell antigens were localized for electron microscopy by the formation of avidin-biotin-peroxidase complexes using direct or indirect labeling techniques. The techniques proved advantageous for identification of lymphocyte subsets bearing two different
Brookmeyer R; Gail MH; Department of Biostatistics, Johns Hopkins University School of; Hygiene and Public Health, Baltimore, Maryland 21205.
Several natural history studies of the Acquired Immunodeficiency Syndrome (AIDS) have been based on the follow-up of individuals infected with the AIDS virus prior to enrollment. The natural time scale for studying the preclinical course of AIDS is the time since first infection; however, in these studies the time at
Chen SJ; Ko HS; Clinical Immunology Unit, University Hospital, London, Ontario,; Canada.
Serum thymosin-alpha 1 levels as detected by radioimmunoassay (RIA) have been reported to be elevated in AIDS. We studied 143 individuals in two risk groups for AIDS (male homosexuals and haemophiliacs) for serum thymosin-alpha 1 and antibodies to HIV. RIA for thymosin-alpha 1 was performed in Dr A. Goldstein s labora
Krauth PH; Katz JF; Department of Diagnostic Radiology, New England Deaconess; Hospital, Boston, Massachusetts 02215.
A 30-year-old man with acquired immune deficiency syndrome (AIDS) and Kaposi s sarcoma had a palpable thyroid mass and cervical lymphadenopathy. Nuclear medicine and ultrasound scans revealed multiple thyroid nodules. Results of biopsy showed Kaposi s sarcoma metastatic to the thyroid.
EMBO J. 1987 Dec 1;6(12):3761-70. Unique Identifier : AIDSLINE MED/88111565
Garcia JA; Wu FK; Mitsuyasu R; Gaynor RB; Department of Medicine, UCLA School of Medicine 90024.
The human immunodeficiency virus (HIV) is a human retrovirus which is the etiologic agent of the acquired immunodeficiency syndrome. To study the cellular factors involved in the transcriptional regulation of this virus, we performed DNase I footprinting of the viral LTR using partially purified HeLa cell extracts. Fi
Goudsmit J; Paul DA; Virology Department, Academic Medical Center, University of; Amsterdam, Netherlands.
Human immunodeficiency virus antigen (HIV-ag) was determined by enzyme immunoassay (EIA) in HIV-antibody (anti-HIV) positive as well as pre-anti-HIV seroconversion sera and the results analysed according to stage of infection, risk group, age and geographic origin. Eleven (19%) of 58 homosexual men tested showed HIV-a
J Community Health. 1987 Winter;12(4):199-212. Unique Identifier : AIDSLINE MED/88116148
Valdiserri RO; Lyter DW; Leviton LC; Stoner K; Silvestre A; University of Pittsburgh School of Medicine, Pa.
As a result of the AIDS (Acquired Immune Deficiency Syndrome) epidemic, many community health agencies are faced with the task of planning and implementing programs to prevent or reduce the risks of HIV (Human Immunodeficiency Virus) infection. Furthermore, the urgency of AIDS will force community groups to develop pr
J Med Virol. 1987 Nov;23(3):241-8. Unique Identifier : AIDSLINE MED/88117428
Titti F; Lazzarin A; Costigliola P; Oliva C; Nicoletti L; Negri C; Ricchi E; Donati G; Uberti-Foppa C; Re MC; et al; Laboratory of Virology, Istituto Superiore di Sanita, University; La Sapienza, Rome, Italy.
The prevalence of human immunodeficiency virus (HIV) antibodies and the symptoms induced [persistent generalized lymphadenopathy (PGL), AIDS-related complex (ARC), acquired immunodeficiency syndrome (AIDS)] was evaluated in several groups of intravenous (IV) drug abusers in three large Italian cities (Milan, Bologna,
McLoughlin LC; Nord KS; Joshi VV; Oleske JM; Connor EM; Department of Pediatrics, Children's Hospital of New Jersey,; UMDNJ-New Jersey Medical School, Newark 07107.
Five children with the acquired immunodeficiency syndrome (AIDS) and unusual gastrointestinal disease are described. Two children presented with malnutrition, abdominal distention, and diarrhea. One was found to have moderately severe villus atrophy on jejunal biopsy and was initially thought to have celiac disease. J
J Psychosoc Nurs Ment Health Serv. 1987 Dec;25(12):21-5. Unique Identifier : AIDSLINE MED/88118449
Graham L; Cates JA; Indiana University-Purdue University, Nursing Department, Fort; Wayne 46805.
As the number of people with AIDS increases, the number of people impacted by the AIDS crisis will also increase. Larger metropolitan areas have already responded to the crisis with various services (Deuchar, 1984); but the disease has yet to fully impact on smaller cities and towns. The formation of community service
Okamoto H; Imai M; Kametani M; Nakamura T; Mayumi M; Immunology Division, Jichi Medical School, Tochigi-ken, Japan.
From the plasma of a 54-year-old woman, who acquired the persistent carrier state of hepatitis B virus through materno-fetal transmission, 49 clones of viral genomes were propagated. They did not reveal any differences in the size and number of cleavage products with any of 11 restriction endonucleases. Randomly selec
Pilla AM; Rybak MJ; Chandrasekar PH; Department of Pharmacy, Wayne State University, Detroit,; Michigan.
Spiramycin, a macrolide antibiotic, has been advocated for the treatment of cryptosporidiosis. The disease most commonly occurs in patients with AIDS and can be debilitating, as diarrhea and malnutrition may be contributing factors in the death of these patients. Until recently, treatment for cryptosporidiosis has bee
Barinskii IF; Gribencha SV; Nesterchuk SL; Zhdanov VM
The effect of some Soviet chemical drugs (ribamydil, sodium phosphonoformate, acycloguanosine) as well as reaferon (genetic engineering alpha-interferon) and interferon inducers (lafarine, ridastine, rifastine, ENKAD) on HIV retrovirus reproduction was studied in cultures of continuous lymphoid cells H9 and a line of
Z Hautkr. 1987 Nov 15;62(22):1603-14. Unique Identifier : AIDSLINE MED/88128939
Oehlschlaegel G; Marquart KH; Engst R; Dermatologische Klinik und Poliklinik der Technischen; Universitat Munchen.
We report on a disseminated variant of Kaposi s sarcoma (M.K.) with a moderate course in a homosexual patient negative for LAV/HTLV-III antibodies. The disease had started at the age of 44 years. Clinical examination proved the patient s good condition. Serological findings revealed numerous former infections. Control
Repeatedly, the AIDS threat has caused the emergence of proposals for obligatory, authoritarian measures. It has above all been conceived to isolate given groups, so that they be prevented to do harm. This is done, however, against the scientific and experiential evidence which shows that such measures would be either
Bruhn P; Department of Neurology, Rigshospitalet, Copenhagen, Denmark.
Retrospective studies of hospitalized patients with the acquired immune deficiency syndrome (AIDS) have indicated that dementia occur in the majority of cases. In order to study the occurrence of dementia among AIDS patients, we conducted a controlled study of 16 unselected cases w
Mizusawa H; Hirano A; Llena JF; Kato T; Department of Pathology, Montefiore Medical Center, Bronx, NY; 10467.
In an autopsied case of a 37-year-old man with acquired immune deficiency syndrome (AIDS), multinucleated giant cell encephalopathy was noted in close proximity to multiple nodules of primary lymphoma of the brain. Some multinucleated giant cells and macrophages contained HTLV-III-like viral particles. Nuclear bridges
Neuropathological examination of brain tissue of 100 patients with infection by the human immunodeficiency virus (HIV), including 98 with clinically manifest acquired immune deficiency syndrome (AIDS), revealed distinct multifocal-disseminated and diffuse brain tissue lesions, which can be regarded as HIV-induced brai
Baba M; Pauwels R; Balzarini J; Herdewijn P; De Clercq E; Desmyter J; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Louvain, Belgium.
The combined antiviral effects of various 2 ,3 -dideoxynucleosides and ribavirin on the replication of human immunodeficiency virus type 1 in MT-4 cells have been examined. Ribavirin antagonized the antiviral activity of the pyrimidine 2 ,3 -dideoxynucleosides (3 -azido-2 ,3 -dideoxythymidine, 2 ,3 -dideoxythymidin-2
Aust N Z J Psychiatry. 1987 Sep;21(3):346-53. Unique Identifier : AIDSLINE MED/88133741
Buhrich N; Cooper DA; Department of Psychiatry, St. Vincent's Hospital, Sydney, NSW.
Psychiatric consultation was requested for 22 of 150 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) admitted to St Vincent s Hospital, Sydney. The mean age of the patients was 35 years and all were homosexual or bisexual men. Ten patients had an organic brain syndrome: six as
Immunol Lett. 1987 Nov;16(2):97-100. Unique Identifier : AIDSLINE MED/88113827
Ritter J; Sepetjan M; Monier JC; Laboratoire de Sante Publique, Faculte Lyon-Nord, France.
The blood rate of alpha 1 thymosin is increased during HIV infection, despite the thymus involution. Anti-alpha 1 thymosin antibodies inhibit HIV replication in vitro. A homology between alpha 1 thymosin and the HIV P17/18 core protein exists and would explain a cross-antigenicity. We have studied the interaction betw
J Med Primatol. 1987;16(6):341-7. Unique Identifier : AIDSLINE MED/88118833
Fultz PN; Greene C; Switzer W; Swenson B; Anderson D; McClure HM; AIDS Program, Centers for Disease Control, Atlanta, GA.
Four uninfected chimpanzees were each housed in separate cages with an HIV-infected chimpanzee for six to twenty-nine months. Despite close daily contact, all uninoculated chimpanzees remained seronegative for HIV, and virus was never isolated from peripheral blood mononuclear cells of the uninfected chimpanzees. Thes
60% of all HIV-infected patients develop neurological deficits during the course of their disease. The facial paralysis of a 47 year old man which presented as a Bell s palsy is nevertheless an unusual first symptom of HIV infection.
Miller G; Martin K; Katz BZ; Andiman WA; Department of Pediatrics, Yale University School of Medicine, New; Haven, Connecticut 06510.
As of December 1986, we have identified 23 symptomatic children with human immunodeficiency virus (HIV) infection in New Haven. Twelve developed AIDS as manifested by lymphocytic interstitial pneumonitis, Pneumocystis carinii pneumonia (PCP), and/or disseminated mycobacterial infections; seven of them have died. The r
Anal Biochem. 1987 Nov 15;167(1):97-105. Unique Identifier : AIDSLINE MED/88131798
Doellgast GJ; Elcatech, Inc. Winston-Salem, North Carolina 27106.
We have applied the enzyme-linked coagulation assay (ELCA) system to the development of an amplified immunoassay using the clotting cascade to enhance sensitivity of detection of immune complexes. The factor X-activating enzyme of Russell s viper venom was detectable using ELCA in amounts as low as 0.25 fg per assay.
de la Barrera S; Fainboim L; Lugo S; Picchio GR; Muchinik GR; de Bracco MM; IIHEMA, Academia Nacional de Medicina, Buenos Aires, Argentina.
The specificity of anti-lymphocyte antibodies was evaluated in AIDS patients and in individuals at risk of AIDS [R-AIDS: male homosexuals (Ho) and haemophiliacs (He)]. Antibodies capable of inducing antibody-dependent cell-mediated cytotoxicity (ADCC) against non-T cells and lymphoblastoid cell lines (P3HR-1K and Raji
Immunol Lett. 1987 Nov;16(2):157-62. Unique Identifier : AIDSLINE MED/88113824
Sei Y; Tsang PH; Petrella RJ; Bekesi JG; Department of Neoplastic Diseases, Mount Sinai School of; Medicine, New York, NY 10029.
Peripheral blood leukocytes from ARC and AIDS patients were examined before and after phytohemagglutinin (PHA) stimulation by dual color flow cytometry and monoclonal antibodies which identify developmental and activational stages of T lymphocytes, B cells and monocytes. There was a persistent elevation in the total n
As one of the most important risk groups for HIV infection 82 intravenous drug addicts were tested in December 85/January 86 and 159 in December 86/January 87 for HIV antibody when entering a detoxification programme of our drug addition outpatient clinic. All these drug addicts had used intravenous drugs, mostly opia
Ann Neurol. 1987 Dec;22(6):700-6. Unique Identifier : AIDSLINE MED/88132612
Rottenberg DA; Moeller JR; Strother SC; Sidtis JJ; Navia BA; Dhawan V; Ginos JZ; Price RW; Department of Neurology, Memorial Sloan-Kettering Cancer Center,; New York, NY.
A progressive dementing illness, the AIDS dementia complex (ADC) is the most frequent neurological complication of the acquired immunodeficiency syndrome. Characteristic alterations in regional cerebral metabolic rate for glucose (rCMRGlc), associated with the presence or progressi
Yajko DM; Nassos PS; Hadley WK; Department of Laboratory Medicine, University of California, San; Francisco General Hospital Medical Center 94110.
A total of 31 strains of Mycobacterium avium complex isolated from patients with acquired immune deficiency syndrome were tested for susceptibility to 30 antimicrobial agents by using microdilution trays containing dried antimicrobial agents. MICs were determined over a period of 7 days of growth in a broth medium (7H
Tartaglione TA; Collier AC; University of Washington, Seattle.
Antiviral agents under investigation for the treatment of patients infected with the human immunodeficiency virus (HIV) are reviewed. Multiple mechanisms exist by which antiviral agents might inhibit the replication of HIV or eradicate its latent form in affected cells, or both. These mechanisms include (1) interferen
Roulot D; Valla D; Brun-Vezinet F; Rey MA; Clavel F; Degott C; Guillan J; Verduron J; Rueff B; Benhamou JP; Service d'Hepatologie, (INSERM U-24), Hopital Beaujon, Clichy,; France.
We report the cases of one patient with the acquired immunodeficiency syndrome as a result of human immunodeficiency virus type 1/lymphadenopathy associated virus type 1/human T-cell lymphotrophic virus type III (HIV-1/LAV-1/HTLV-III) infection and of another patient with AIDS related complex caused by human immunodef
Sano K; Lee MH; Morales F; Nishanian P; Fahey J; Detels R; Imagawa DT; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance; 90509.
Most individuals infected with human immunodeficiency virus (HIV), the causative agent of acquired immune deficiency syndrome, produce an antibody against the viral reverse transcriptase (RT). Our studies show that 67% of HIV-seropositive individuals (33 of 49) produced an antibody that specifically inhibited viral RT
J Med Virol. 1987 Nov;23(3):217-24. Unique Identifier : AIDSLINE MED/88117425
Burkhardt U; Mertens T; Eggers HJ; Institut fur Virologie, Universitat zu Koln, Federal Republic; of Germany.
Serum specimens were tested for HIV antibodies by two commercially available ELISAs (Abbott HTLV III EIA and Du Pont HTLV III-ELISA). The specificity and sensitivity of these assays were determined by comparison with indirect immunofluorescence and Western blot analysis. Specificity ranged from 94.3% in the Abbott ass
Klin Wochenschr. 1987 Nov 2;65(21):1042-7. Unique Identifier : AIDSLINE MED/88120126
Lenz A; von Hintzenstern J; Erlwein O; Ellinger S; Broker M; Fleckenstein B; Jahn G; Institut fur Klinische und Molekulare Virologie der Universitat; Erlangen-Nurnberg.
Serologic testing for human immunodeficiency virus type 1 (HIV-1) is currently based on enzyme linked immunosorbent assay (ELISA) as screening method. Positive ELISA-results have to be confirmed by at least one second procedure such as Western blotting or immunofluorescence. To obtain new diagnostic reagents for confi
Vengerov IuIu; Parfanovich MI; Iaroslavtseva NG; Vorob'ev SM; Semenov TE
The ELISA test using beta-lactamase for the detection of anti-AIDS virus antibodies and virus antigen in serum is described. The properties of this test system are compared with those of the system based on horseradish peroxidase conjugates.
Cohn HD; Department of Medicine and Surgery, VA Central Office,; Washington, D.C. 20420.
Acquired immune deficiency syndrome (AIDS), a devastating disease with numerous masks (e.g., a primary neurosymptomatic disease), has now been reported in over one hundred countries of the world. Projections by the Public Health Service of the numbers of cases and fatal illnesses in the Un
D'Aquila RT; Williams AB; Department of Medicine, Yale University School of Medicine, New; Haven, Connecticut 06510.
Human immunodeficiency virus (HIV) infection is epidemic among intravenous drug users (IVDU), particularly in the northeastern United States . IVDU are playing a critical role in the spread of HIV by infecting their heterosexual partners and children, as well as their needle-sharing par
Griffith BP; Virology Reference Laboratory, Veterans Administration Medical; Center, West Haven, CT 06516.
Diagnosis of human immunodeficiency virus (HIV) infections has relied most frequently on detecting the presence of HIV antibodies in sera. In many situations, however, patients management can be significantly improved if the presence of HIV can be demonstrated in patients specimens. In this review, the need and value
Ho DD; Kaplan JC; Division of Infectious Diseases, Cedars-Sinai Medical Center, Los; Angeles, California.
In just six years after the initial description of the acquired immunodeficiency syndrome, much has been learned about the etiologic agent, the human immunodeficiency virus. The pathogenic mechanisms utilized by this virus to infect selectively and persistently T4+ lymphocytes and monocyte/macrophages, leading to immu
Z Rechtsmed. 1987;99(3):169-80. Unique Identifier : AIDSLINE MED/88129121
Kaatsch HJ; Institut fur Rechtsmedizin der Justus-Liebig-Universitat; Giessen, Bundesrepublik Deutschland.
Currently, liability discussions are being dominated by AIDS and the legal problems associated with birth and death. The introduction of routine AIDS tests without the knowledge of those concerned is disputed heatedly and, in fact, may well constitute bodily assault and render those responsible liable to prosecution.
A 15 month old child with a history of multiple infectious diseases was admitted to hospital for investigation of pyrexia and general ill health. She was anaemic with a persistent neutropaenia associated with hypergamma globulinemia, indicating intense autoimmune activity: cellular immunity was abnormal with a normal
De Clercq E; Department of Human Biology, Katholieke Universiteit Leuven,; Belgium.
In the design of selective inhibitors of the human immunodeficiency virus (HIV), the etiologic agent of AIDS, various steps of the virus replicative cycle could be envisaged as targets, i.e. virus adsorption to its cellular receptor (or another early event in virus replication such as penetration or uncoating), transc
Safai B; Lynfield R; Lowenthal DA; Koziner B; Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
The spectrum of neoplastic disease seen in patients with the acquired immune deficiency syndrome (AIDS) is similar to that seen in several congenital and iatrogenic immunodeficiency states and provides a human model for studying neoplastic transformation in the immune compromised host. High grade lymphoid neoplasia, p
Schulze HJ; Rutten A; Mahrle G; Steigleder GK; Department of Dermatology, University of Cologne, Federal; Republic of Germany.
Kaposi s sarcoma (KS) in human immunodeficiency virus infection (HIV) has become a rather frequent manifestation of the previously rare disease with fatal outcome. Initial lesions of KS were studied by means of histopathology, immunohistology, and electron microscopy in order to define the earliest alterations. The hi
Ameglio F; Benedetto A; Marotta P; Centis D; Sorretino R; Tanigaki N; Tosi R; Regina Elena Institute for Cancer Research, Rome, Italy.
The anti-HLA reactivity of sera from 210 heroin addicts was tested by the direct binding with 125I-labeled preparations of HLA class I and class II molecules purified from human B-cell lines of various HLA haplotypes. A high proportion (81.7%) of the sera tested possessed anti-HLA class I and II reactivity. The reacti
In the UK surveillance of AIDS and HIV infection is based on routine reporting systems. Whilst attempts are made to ensure that AIDS data are as complete as possible, numbers of reports fluctuate from month to month for reasons which are described. In 1986 there was an increase in death certificates naming AIDS as a c
Lin RY; Department of Medicine, Metropolitan Hospital-NYMC, New York.
A 35-year-old Black male with a long history of intravenous drug abuse developed clinical manifestations of Reiter s syndrome, with significant joint and psoriasiform skin involvement. In addition, he had signs and symptoms compatible with human immunodeficiency virus (HIV) infection and had a positive HIV antibody te
Conant MA; Department of Dermatology, University of California, San; Francisco 94117.
During 1 year of continuous suppressive therapy for frequent recurrent genital herpes , about 44% of patients taking 400 mg acyclovir twice a day had no recurrences and 4% of patients taking placebo had no recurrences (i.e., fewer patients
Weiler PG; Mungas D; Pomerantz S; Department of Community Health, School of Medicine, UC Davis; 95616.
It has been recognized that AIDS can present initially as dementia without other neurological or clinical manifestations. In addition, HIV-contaminated blood transfusions in the elderly seem to be underreported. Because of these findings, dementia in the elderly may be misdiagnosed
Coates RA; Fanning MM; Johnson JK; Calzavara L; Department of Preventive Medicine, Faculty of Medicine,; University of Toronto, Canada.
The degree of clinical agreement amongst different physicians on the presence or absence of generalized lymphadenopathy was assessed in 32 randomly selected participants from a prospective study of male sexual contacts of men with AIDS or an AIDS-related condition (ARC). Three physicians completed the same standard ex
J Med Chem. 1988 Feb;31(2):336-40. Unique Identifier : AIDSLINE MED/88118741
Lin TS; Guo JY; Schinazi RF; Chu CK; Xiang JN; Prusoff WH; Department of Pharmacology, Yale University School of Medicine,; New Haven, Connecticut 06510.
Various 3 -azido analogues of pyrimidine deoxyribonucleosides have been synthesized and tested against human immunodeficiency virus (HIV-1, HTLV-III/LAV) in human peripheral blood mononuclear cells. Among these compounds, the 3 -azido analogues of thymidine (2), 3-(3-oxo-1-propenyl)thymidine (21), 2 -deoxyuridine (1),
JAMA. 1988 Mar 4;259(9):1333-7. Unique Identifier : AIDSLINE MED/88119432
Marzuk PM; Tierney H; Tardiff K; Gross EM; Morgan EB; Hsu MA; Mann JJ; Department of Psychiatry, Cornell University Medical College, New; York, NY 10021.
The rate of suicide has been reported to be higher in persons with chronic and life-threatening illnesses (eg, cancer, Huntington s disease, and renal failure). We studied the rate of suicide in 1985 in New York City residents diagnosed with the acquired immunodeficiency syndrome (AIDS). There were 668 suicides in New
JAMA. 1988 Mar 4;259(9):1338-42. Unique Identifier : AIDSLINE MED/88119433
Castro KG; Lifson AR; White CR; Bush TJ; Chamberland ME; Lekatsas AM; Jaffe HW; AIDS Program, Centers for Disease Control, Atlanta, GA 30333.
Through Sept 30, 1987, two thousand fifty-nine patients with acquired immunodeficiency syndrome (AIDS) and no recognized risk factors were reported to the Centers for Disease Control. Risk history was incomplete or unobtainable for 921 (45%) of them. Risk factors were ultimately identified for 825 (72%) of the remaini
Rance NE; McArthur JC; Cornblath DR; Landstrom DL; Griffin JW; Price DL; Department of Neurology, Johns Hopkins University School of; Medicine, Baltimore, MD.
At autopsy, four homosexual men with acquired immunodeficiency syndrome (AIDS) were found to have selective degeneration of the gracile tract, a finding previously unreported in AIDS. Clinically, these patients had progressive lower extremity paresthesias and dysesthesias with reduced or absent ankle jerks, and eventu
Science. 1988 Feb 5;239(4840):580-6. Unique Identifier : AIDSLINE MED/88127111
Dickens BM; University of Toronto, Canada.
This article provides an overview of some major areas of legal concern in which the AIDS epidemic is having an impact. The rights of infected individuals to testing, treatment, and confidentiality are reviewed, and emphasis is given to their claims to nondiscrimination regarding access to health care, employment, hous
Science. 1988 Feb 5;239(4840):592-6. Unique Identifier : AIDSLINE MED/88127113
Fineberg HV; Harvard School of Public Health, Boston, MA 02115.
A number of obstacles thwart effective education to prevent AIDS in the United States . These include the biological basis and social complexity of the behaviors that must be changed, disagreement about the propriety of educational messages to prevent AIDS, uncertainty about the degree
Science. 1988 Feb 5;239(4840):597-603. Unique Identifier : AIDSLINE MED/88127114
Walters L; Center for Bioethics, Kennedy Institute of Ethics, Washington, DC; 20057.
The epidemic of infection with the human immunodeficiency virus (HIV) and the acquired immunodeficiency syndrome (AIDS) poses a major ethical question: How can we control the epidemic and the harm that it causes without unjustly discriminating against particular social groups and without unnecessarily infringing on th
Science. 1988 Feb 5;239(4840):610-6. Unique Identifier : AIDSLINE MED/88127116
Curran JW; Jaffe HW; Hardy AM; Morgan WM; Selik RM; Dondero TJ; AIDS Program, Centers for Disease Control, Atlanta, Georgia; 30333.
By the end of 1987, nearly 50,000 cases of acquired immunodeficiency syndrome (AIDS) had been reported since 1981, 20,745 in the past year alone. Black and Hispanic adults and children have reported rates 3 to 12 times as high as whites. This can be largely attributed to higher reported rates in black and Hispanic int
Inagaki M; Miura T; Taki M; Saito N; Yamada K; Unuma T; Tsuda F; Miyakawa Y; Mayumi M; Department of Pediatrics, Keio University, Tokyo, Japan.
Two hundred two patients with hemophilia, dependent solely on imported coagulation factor concentrates, were tested for markers of hepatitis B virus infection, antibody to hepatitis delta virus (anti-HD), and antibody to human immunodeficiency virus (anti-HIV). Nine carriers of hepatitis B surface antigen (HBsAg) were
Goldsmith JC; Kisker CT; Department of Medicine, University of Nebraska, Omaha.
Hematologic abnormalities, including thrombocytopenia, have been reported in persons with acquired immune deficiency syndrome and in hemophiliacs. Seven of 92 adult hemophiliacs followed in a comprehensive hemophilia center developed mild to moderately severe thrombocytopenia in 1983. All had benign courses. None requ
Torssander J; Karlsson A; Morfeldt-Manson L; Putkonen PO; Wasserman J; Department of Dermatology, Sodersjukhuset, Stockholm, Sweden.
Mycological and clinical investigations were carried out in 193 homosexual men, 83 of whom had HIV antibodies, and 117 heterosexual men. Dermatophytes were recovered from the feet in 37.3% of HIV seropositive homosexual men, 31.8% of seronegative homosexual men and 8.6% of heterosexual men. Tinea pedis in homosexual m
Govindarajan S; Fong TL; Valinluck B; Edwards V; Redeker AG; University of Southern California Liver Unit, Department of; Pathology and Medicine, Rancho Los Amigos Medical Center, Downey; 90242.
Serum samples from 56 patients with biopsy-proven chronic B viral hepatitis without superimposed delta hepatitis were analyzed for the various markers of viral replication, including serum hepatitis B e Ag (HBeAg), hepatitis B virus deoxyribonucleic acid (HBV-DNA), and hepatitis B core antigen (HBcAg) in the liver tis
Central nervous system (CNS) dysfunction was documented in 61 of 68 infants and children with symptomatic human immunodeficiency virus infection. The most frequent manifestations included acquired microcephaly, cognitive deficits, and bilateral pyramidal tract signs. Lymphoma of the CNS, cerebrovascular accidents, and
Am J Pathol. 1988 Feb;130(2):244-51. Unique Identifier : AIDSLINE MED/88131249
Scully PA; Steinman HK; Kennedy C; Trueblood K; Frisman DM; Voland JR; Department of Pathology, University of California, San Diego, La; Jolla 92093.
The authors studied 11 cases of Kaposi s sarcoma (KS) in patients with the acquired immunodeficiency syndrome (AIDS) for their reactivity with two monoclonal antibodies (B721 and E431) that recognize endothelial cell surface antigens. Reactivity of these antibodies with KS was compared with the reactivity of other kno
Patients undergoing chronic hemodialysis receive multiple blood transfusions and, thus, are susceptible to infections transmitted through blood and blood products, including infection with human immunodeficiency virus (HIV). To determine the prevalence of antibody to HIV among patients undergoing chronic hemodialysis
N Engl J Med. 1988 Feb 25;318(8):473-8. Unique Identifier : AIDSLINE MED/88122313
Ward JW; Holmberg SD; Allen JR; Cohn DL; Critchley SE; Kleinman SH; Lenes BA; Ravenholt O; Davis JR; Quinn MG; et al; AIDS Program, Centers for Disease Control, Atlanta, GA 30333.
Since early 1985, blood donations in the United States have been screened for antibody to human immunodeficiency virus (HIV). To identify instances of HIV transmission by antibody-negative donations, we investigated 13 persons seropositive for HIV who had received blood from 7 donors w
Syrjanen S; Valle SL; Antonen J; Suni J; Saxinger C; Krohn K; Ranki A; Institute of Dentistry, University of Kuopio, Finland.
The oral mucosae of 66 homosexual men were examined clinically and by means of cultivation to determine the presence of Candida infection. In addition, clinically detected mucosal changes were recorded and a biopsy specimen was obtained for the histopathologic classification. A total of forty one subjects (62%) showed
Ann Intern Med. 1988 Mar;108(3):372-6. Unique Identifier : AIDSLINE MED/88132165
Walker RE; Parker RI; Kovacs JA; Masur H; Lane HC; Carleton S; Kirk LE; Gralnick HR; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland.
We evaluated the development of anemia as part of a trial of zidovudine therapy in patients with the acquired immunodeficiency syndrome (AIDS) with Kaposi sarcoma. Patients were randomized to one of three treatment groups or a placebo group. Transfusion-requiring anemia (hemoglobin less than 100 g/L) developed in 6 of
Cancer. 1988 Mar 1;61(5):947-51. Unique Identifier : AIDSLINE MED/88109306
Nasr SA; Brynes RK; Garrison CP; Chan WC; Department of Pathology and Laboratory Medicine, Emory; University, Atlanta, GA 30322.
A case of pulmonary T-cell lymphoma in an Acquired Immune Deficiency Syndrome (AIDS) patient is presented. Morphologically, it belonged to the large cell, immunoblastic category of the Working Formulation and demonstrated a helper/inducer phenotype. Clinically there was no association with manifestations of human T-ly
Chanh TC; Kennedy RC; Kanda P; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, Texas 78284.
Human immunodeficiency virus (HIV) envelope glycoprotein is synthesized as a polyprotein precursor of 160 kDa (gp 160) and is subsequently cleaved into an amino terminus subunit, gp 120, and a carboxyl terminus transmembrane subunit, gp 41. Two synthetic peptides corresponding to amino acid sequences 735-752 and 846-8
de Martini RM; Turner RR; Formenti SC; Boone DC; Bishop PC; Levine AM; Parker JW; Department of Pathology, University of Southern California School; of Medicine, Los Angeles 90033.
Quantitative abnormalities of leukocyte subpopulations have been shown to correlate with clinical status in human immunodeficiency virus (HIV) infection. We have performed peripheral blood leukocyte phenotyping in 23 HIV-seropositive homosexual men, and correlated the results with clinical follow-up information. Indiv
Kaplan J; Sarnaik I; Lusher J; Department of Pediatrics, Wayne State University School of; Michigan, Detroit, Michigan 48201.
The fact that patients with hemophilia treated with clotting factor and HIV 1-seronegative subjects with congenital anemias given repeated blood transfusions both have decreased ratios of T4/T8 lymphocytes and diminished NK cell activity indicates that these immunological abnormalities can be due to repeated exposure
Amadori A; De Rossi A; Faulkner-Valle GP; Chieco-Bianchi L; Institute of Oncology, University of Padova, Italy.
In vitro synthesis of IgG directed against HIV components was detected by ELISA and Western blot assay of lymphocyte culture supernatants. Lymphocytes from HIV-infected individuals spontaneously produced antibody against HIV proteins very early in culture, suggesting in vivo activation of HIV-specific antibody-forming
Adams LE; Donovan-Brand R; Friedman-Kien A; el Ramahi K; Hess EV; Department of Internal Medicine, University of Cincinnati, Ohio; 45267.
Although HIV has been established as the etiologic agent in AIDS, other contributory cofactors may be responsible for selective clinical manifestations of the syndrome. While the pathogenesis remains unclear, the development of immunologic abnormalities observed in some homosexual males with AIDS and AIDS-related comp
J Immunol. 1988 Feb 1;140(3):786-95. Unique Identifier : AIDSLINE MED/88116692
Hoxie JA; Rackowski JL; Haggarty BS; Gaulton GN; Hematology-Oncology Section, Hospital of the University of; Pennsylvania, Philadelphia 19104.
The T4 (CD4) molecule has been shown to facilitate the interactions of T cells with HLA class II determinants, to function as a signal transducing molecule, and to serve as a receptor for HIV. Recent studies demonstrated that both phorbol esters and antigen stimulation induced the rapid and transient modulation and ph
JAMA. 1988 Feb 26;259(8):1185-9. Unique Identifier : AIDSLINE MED/88119405
Fischl MA; Dickinson GM; La Voie L; Division of General Internal Medicine, University of Miami School; of Medicine, FL 33101.
The safety and efficacy of sulfamethoxazole and trimethoprim in the prevention of Pneumocystis carinii pneumonia associated with the acquired immunodeficiency syndrome (AIDS) were evaluated. Sixty patients with a new diagnosis of Kaposi s sarcoma and no history of opportunistic infections were randomly assigned to rec
Nature. 1988 Jan 7;331(6151):82-4. Unique Identifier : AIDSLINE MED/88122542
Deen KC; McDougal JS; Inacker R; Folena-Wasserman G; Arthos J; Rosenberg J; Maddon PJ; Axel R; Sweet RW; Smith Kline and French Laboratories, King of Prussia,; Pennsylvania 19406.
CD4 (T4) is a glycoprotein of relative molecular mass 55,000 (Mr 55K) on the surface of T lymphocytes which is thought to interact with class II MHC (major histocompatibility complex) molecules, mediating efficient association of helper T cells with antigen-bearing targets. The CD4 protein is also the receptor for HIV
Pifer LL; Woods DR; Edwards CC; Joyner RE; Anderson FJ; Arheart K; Department of Pediatrics, University of Tennessee, Memphis 38163.
Pneumocystis carinii antigen and IgG antibody profiles were prepared on 17 pediatric patients with acquired immunodeficiency syndrome (AIDS) with pneumonia who were examined by a variety of invasive methods for P carinii organisms. Overall, the accuracy of the antigen assay in invasively examined pediatric patients wi
Am J Hematol. 1988 Feb;27(2):144-5. Unique Identifier : AIDSLINE MED/88131006
Nahum K; Saidi P; Kim HC; Karp GI; Department of Medicine, University of Medicine and Dentistry of; New Jersey, New Brunswick 08903-0019.
Adverse reactions to trimethoprim-sulfamethoxazole are very prevalent in patients with acquired immunodeficiency syndrome (AIDS). Recently we have observed severe toxicities associated with trimethoprim-sulfamethoxazole in three hemophiliacs, a group known to be at risk for developing AIDS. At the time of these reacti
Sankary RM; Turner J; Lipavsky A; Howes EL Jr; Murray JF; Chest Service, San Francisco General Hospital Medical Center, CA; 94110.
To determine the value of subdividing diffusing capacity for carbon monoxide (DL) in diagnosing and monitoring the course of Pneumocystis carinii pneumonia (PCP), we measured DL, membrane diffusing capacity (DM), and pulmonary capillary blood volume (VC) in 20 control subjects, 20 patients with a low DL (less than 75%
Montgomery AB; Debs RJ; Luce JM; Corkery KJ; Turner J; Brunette EN; Lin ET; Hopewell PC; Medical Service, San Francisco General Hospital Medical Center,; California.
In 8 patients with diffuse infiltrates on chest radiograph undergoing fiberoptic bronchoscopy for suspected Pneumocystis carinii pneumonia, bronchoalveolar lavage sediment and supernatant concentrations of pentamidine were compared 18 to 24 h after administration of 4 mg/kg intravenous (n = 3) and aerosolized (n = 5)
Milligan SA; Luce JM; Golden J; Stulbarg M; Hopewell PC; Medical Service, San Francisco General Hospital Medical Center,; California.
Transbronchial biopsy with the flexible fiberoptic bronchoscope is usually performed with the assistance of fluoroscopy in order to increase diagnostic yield and decrease the incidence of pneumothorax. We have compared the results of transbronchial biopsy performed with or without fluoroscopic guidance in patients wit
Millman RB; Department of Psychiatry, Cornell University Medical College, New; York, NY 10021.
The development of an individualized treatment program for cocaine abusers requires a comprehensive assessment of the psychobiological, social, and pharmacological elements that determined the drug abuse behavior as well as those elements that resulted from the behavior. A working knowledge of the disease model of che
de Graaff J; van Amerongen WE; Mulder GR; Department of Paediatric Dentistry, ACTA, Vrije Universiteit,; Amsterdam, The Netherlands.
On the basis of the description of potential pathogens and possibilities of contamination during dental treatment in Part I, Part II discusses several measures to be taken, in order to reduce the risk of contamination for patients as well as for dental personnel. The hygienic measures mostly concern the treatment of p
Messerschmidt GL; Henry DH; Snyder HW Jr; Bertram J; Mittelman A; Ainsworth S; Fiore J; Viola MV; Louie J; Ambinder E; et al; Protein A Clinical Trial Group, Wilford Hall USAF Medical Center,; San Antonio, TX.
Circulating immune complexes (CIC) are known to be present in cancer patients and are responsible for much of the cancer-associated immunosuppression. Removal or modulation of these blocking factors can reverse the immunosuppression. Protein A from Staphylococcus aureus has the unusual property of binding to CIC with
Mayo Clin Proc. 1988 Feb;63(2):161-74. Unique Identifier : AIDSLINE MED/88120492
Reynolds HY; Pulmonary Section, Yale University School of Medicine, New Haven,; Connecticut 06510.
Immunoglobulin G--which can be subdivided into four classes, each with different functional characteristics--is an important component of the host defense system of the respiratory tract. An excessive amount can be produced or can accumulate after airway irritation (exposure to cigarette smoke) or from immunologic sti
N Engl J Med. 1988 Mar 3;318(9):525-30. Unique Identifier : AIDSLINE MED/88122328
Hoff R; Berardi VP; Weiblen BJ; Mahoney-Trout L; Mitchell ML; Grady GF; State Laboratory Institute, Massachusetts Department of Public; Health, Jamaica Plain 02130.
Attempts to predict the course of the epidemic of acquired immunodeficiency syndrome (AIDS) have been hampered by the lack of an objective, practical way to estimate the prevalence of infection with the human immunodeficiency virus (HIV) in the general population. Testing for the prevalence of HIV infection in women s
Proc Natl Acad Sci U S A. 1988 Feb;85(4):1028-32. Unique Identifier : AIDSLINE MED/88124968
Wickstrom EL; Bacon TA; Gonzalez A; Freeman DL; Lyman GH; Wickstrom E; Department of Chemistry, University of South Florida, Tampa; 33620.
The human promyelocytic leukemia cell line HL-60 overexpresses the c-myc protooncogene. A calculated secondary structure for c-myc mRNA placed the initiation codon in a bulge of a weakly base-paired region. Treatment of HL-60 cells with 5 d(AACGTTGAGGGGCAT) 3 , complementary to the initiation codon and the next four
Proc Natl Acad Sci U S A. 1988 Feb;85(4):1218-22. Unique Identifier : AIDSLINE MED/88125007
Hizi A; McGill C; Hughes SH; National Cancer Institute-Frederick Cancer Research Facility,; Bionetics Research Inc.-Basic Research Program, MD 21701.
We have constructed a plasmid that, when introduced into Escherichia coli, induces the synthesis of large quantities of a protein with an apparent molecular mass of 66 kDa that differs from human immunodeficiency virus (HIV) RNA-dependent DNA polymerase (deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase or
Bradford BF; Abdenour GE Jr; Frank JL; Scott GB; Beerman R; University of Miami School of Medicine, Florida.
AIDS is being recognized with ever-increasing frequency in children. This article includes a discussion of the common radiographic manifestations of AIDS as well as some rarely encountered problems. It is hoped that with heightened awareness of this spectrum of radiographic findings, radiologists may contribute to a p
Science. 1988 Feb 5;239(4840):573-9. Unique Identifier : AIDSLINE MED/88127110
Piot P; Plummer FA; Mhalu FS; Lamboray JL; Chin J; Mann JM; Department of Microbiology, Institute of Tropical Medicine,; Antwerp, Belgium.
The acquired immunodeficiency syndrome (AIDS) and infection with the human immunodeficiency virus type 1 (HIV-1) constitute a worldwide public health problem. Whereas in Europe and in most of the Americas transmission of HIV-1 has occurred predominantly among homosexual men and intravenous drug abusers, in Africa a di
Science. 1988 Feb 5;239(4840):586-92. Unique Identifier : AIDSLINE MED/88127112
Price RW; Brew B; Sidtis J; Rosenblum M; Scheck AC; Cleary P; Department of Neurology, Memorial Hospital, New York, NY 10021.
Infection with human immunodeficiency virus type 1 (HIV-1) is frequently complicated in its late stages by the AIDS dementia complex, a neurological syndrome characterized by abnormalities in cognition, motor performance, and behavior. This dementia is due partially or wholly to a
Science. 1988 Feb 5;239(4840):604-10. Unique Identifier : AIDSLINE MED/88127115
Bloom DE; Carliner G; Columbia University, New York, NY 10027.
This analysis of several previous studies of the cost of AIDS suggests that the lifetime cost of medical care per patient will not exceed +80,000, an amount similar to the cost of treating other serious illnesses. If current projections of future AIDS cases are accurate, the cumulative lifetime costs of 270,000 cases
Science. 1988 Feb 5;239(4840):617-22. Unique Identifier : AIDSLINE MED/88127117
Fauci AS; National Institute of Allergy and Infectious Diseases, Bethesda,; MD 20892.
Infection with the human immunodeficiency virus (HIV) results in a profound immunosuppression due predominantly to a selective depletion of helper/inducer T lymphocytes that express the receptor for the virus (the CD4 molecule). HIV also has tropism for the brain leading to neuropsychiatric abnormalities. Besides indu
Science. 1988 Feb 19;239(4842):910-3. Unique Identifier : AIDSLINE MED/88127162
Sadaie MR; Benter T; Wong-Staal F; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892.
Point mutations were introduced into the overlapping trans-regulatory genes (tat-III and trs) of human immunodeficiency virus type 1 (HIV-1), and the mutants were evaluated for virus expression. The results showed that tat-III has a positive transacting role and is required for transcriptional activation. A chain term
Lipsett P; Allo MD; Department of Surgery, Johns Hopkins Medical Institutions,; Baltimore, Maryland.
Several issues related to the AIDS virus concern the surgeon. This article discusses the common presentations of AIDS in each body system with special emphasis on conditions that require surgical intervention, alternatives to surgical procedures for diagnosis, and precautions for the handling of tissue and body secret
Ann Intern Med. 1988 Mar;108(3):321-7. Unique Identifier : AIDSLINE MED/88132156
Pomerantz RJ; de la Monte SM; Donegan SP; Rota TR; Vogt MW; Craven DE; Hirsch MS; Infectious Disease Unit, Massachusetts General Hospital, Boston.
Human immunodeficiency virus (HIV) has been detected in cervical secretions from HIV-infected women. We report the isolation of HIV from four cervical biopsy specimens. Cervicitis was shown by immunohistochemical staining in cervical biopsy specimens from four HIV-seropositive women; cervicitis was not found in cervic
Pollak AN; Janinis J; Green D; Department of Medicine, Northwestern University Medical School,; Chicago, IL.
High-dose intravenous (IV) immune globulin was used to treat human immunodeficiency virus (HIV)-associated thrombocytopenia four times in three patients. The average platelet count at initiation of therapy was 12 x 10(9)/L (12 x 10(3)/mm3), and the platelet count after therapy was 159 x 10(9)/L (159 x 10(3)/mm3), givi
Lange JM; Paul DA; de Wolf F; Coutinho RA; Goudsmit J; Department of Virology, Academic Medical Centre, University of; Amsterdam, The Netherlands.
Human immunodeficiency virus (HIV) antigen (HIV-Ag) in polyethylene glycol (PEG) precipitates and supernatants and HIV antibodies (HIV-Ab) to core and envelope antigens were studied in serial serum samples of three HIV-Ab seroconverters and 11 HIV-Ab seropositive men with a mean follow-up time of 16.1 months. In five
Fox R; Eldred LJ; Fuchs EJ; Kaslow RA; Visscher BR; Ho M; Phair JP; Polk BF; AIDS Program, NIAID, Bethesda, MD 20892.
During a prospective study of the natural history of human immunodeficiency virus (HIV) infection in a cohort of gay/bisexual men, information on self-reported symptoms lasting for 3 or more days during the previous 6 months was collected without knowledge of the subject s HIV serological status. Twenty-two people wer
Marmor M; Des Jarlais DC; Cohen H; Friedman SR; Beatrice ST; Dubin N; el-Sadr W; Mildvan D; Yancovitz S; Mathur U; et al; Department of Environmental Medicine, New York University Medical; Center, NY.
We report here the results of a survey of 308 intravenous drug abusers recruited from hospital-based methadone maintenance or drug detoxification programmes located in Manhattan, New York City. Complete interviews and serological analyses for antibodies to human immunodeficiency virus (HIV) using both enzyme-linked im
Joller-Jemelka HI; Joller PW; Muller F; Schupbach J; Grob PJ; Department of Internal Medicine, University Hospital, Zurich,; Switerland.
In a prospective study we tested the appearance of IgG and IgM positive viral protein bands in Western blots from six people who seroconverted for anti-HIV antibody. Quantification of the immunoblotted bands was performed by reading the Western blot stripes in Camag scanner and analysed on a 350 computer (digital equi
Van de Perre P; Jacobs D; Sprecher-Goldberger S; Saint-Pierre University Hospital, Laboratory of Microbiology,; Brussels, Belgium.
Using a mechanical model, we studied human immunodeficiency virus (HIV) leakage through six different trademark condoms. The presence of the recovered virus was determined after passage to MT-2 cells and to cultured mitogen-stimulated normal human peripheral blood mononuclear cells (PMC). Only the natural membrane con
Downs AM; Ancelle RA; Jager HJ; Brunet JB; WHO Collaborating Centre on AIDS, Hopital Claude Bernard, Paris,; France.
European AIDS surveillance data, reported to the World Health Organization (WHO) Collaborating Centre on AIDS, Paris by 30 June 1986, have been analysed statistically to assess current trends and to provide short-term predictions. Reported case numbers were first adjusted to allow for
Sewankambo N; Mugerwa RD; Goodgame R; Carswell JW; Moody A; Lloyd G; Lucas SB; Department of Medicine, Makerere University Medical School; Kampala, Uganda.
Twenty-three Ugandan patients with enteropathic acquired immunodeficiency syndrome (AIDS, slim disease) were studied. Upper gastrointestinal (GI) endoscopy, colonoscopy, biopsy, stool parasitology and culture were performed. Endoscopy revealed oral and/or oesophageal candidiasis in 22 patients. Stool examination and
Br Med J (Clin Res Ed). 1988 Jan 9;296(6615):83-6. Unique Identifier : AIDSLINE MED/88108702
Mabey DC; Tedder RS; Hughes AS; Corrah PT; Goodison SJ; O'Connor T; Shenton FC; Lucas SB; Whittle HC; Greenwood BM; Medical Research Council Laboratories, The Gambia.
The prevalence of infection with human immunodeficiency virus type 1 (HIV 1) is lower in west Africa than in other parts of Africa. Human immunodeficiency virus type 2 (HIV 2) has been isolated from west African patients and may be transmitted by heterosexual contact. The prevalence of antibodies to HIV 1 and HIV 2 wa
Br Med J (Clin Res Ed). 1988 Jan 9;296(6615):92-3. Unique Identifier : AIDSLINE MED/88108705
Barrison IG; Foster S; Harris JW; Pinching AJ; Walker JG; Department of Gastroenterology, St Mary's Hospital and Medical; School, London.
Six patients with antibodies to the human immunodeficiency virus (HIV) and with persistent gastrointestinal symptoms of HIV infection but without cutaneous lesions of Kaposi s sarcoma underwent endoscopy. Four also underwent barium meal examination. In all six cases small lesions were seen in the stomach at endoscopy,
Pizzolo G; Vinante F; Sinicco A; Chilosi M; Agostini C; Perini A; Zuppini B; Semenzato G; Battistella L; Foa R; Cattedra di Ematologia and Istituto di Anatomia Patologica,; University of Verona, Italy.
The serum levels of a soluble form of the interleukin-2 receptor (sIL-2R) were investigated in 92 patients with human immunodeficiency virus (HIV) infection, ranging from asymptomatic cases to full-blown AIDS. Increased values were found in 69.5% of cases. The overall mean was significantly higher (p less than 0.001)
Takahashi H; Tatewaki W; Nagayama R; Hanano M; Tamura M; Yamaguchi T; Takizawa S; Wada K; Shibata A; First Department of Internal Medicine, Niigata University School; of Medicine, Japan.
Cryoprecipitate has proved to correct the hemostatic defects in von Willebrand s disease (vWD) and platelet-type vWD. However, recent studies have revealed that transmission of the AIDS retrovirus (HIV) occurs through exposure to blood products including cryoprecipitate. Treatment with heat-treated factor VIII/von Wil
Feorino P; Forrester B; Schable C; Warfield D; Schochetman G; AIDS Program, Centers for Disease Control, Atlanta, Georgia; 30333.
We compared an antigen capture assay ( Abbott Laboratories , North Chicago, Ill.) with a reverse transcriptase assay to identify and quantify human immunodeficiency virus (HIV) in culture. In direct comparisons of serial dilutions of lymphadenopathy-associated virus type 1, the anti
Human immunodeficiency virus (HIV) p24 was purified to homogeneity and subjected to NH2-terminal sequencing. The sequence determined perfectly corresponded to the amino acid sequence predicted from the nucleotide sequence of a middle portion of the HIV first open frame: the gag gene. Edman degradation of purified HIV
Public Health Rep. 1988 Jan-Feb;103(1):54-8. Unique Identifier : AIDSLINE MED/88125772
Ragni MV; Gupta P; Rinaldo CR; Kingsley LA; Spero JA; Lewis JH; University of Pittsburgh School of Medicine, PA.
To study heterosexual transmission of the human immunodeficiency virus (HIV), 21 HIV antibody-positive hemophiliacs and their 21 spouses-sexual partners were evaluated. None belonged to other AIDS risk groups. HIV antibody was detected in four (19 percent) of the female partners. HIV was isolated from peripheral blood
Lazzarin A; Barcellini W; Uberti Foppa C; Borghi MO; Franzetti R; Cinque P; Moroni M; Istituto Policattedra Medicina Interna, Universita di Milano,; Italia.
Drug addicts with persistent generalized lymphadenopathy displayed the following immunological abnormalities: an inverted OKT4/OKT8 ratio, a depressed in vitro blastogenetic response to phytohemagglutinin and pokeweed mitogen (PWM), a reduced ability of PMNL to phagocytose and kill Candida albicans spores and to migra
Gutteridge CN; Veys P; Newland AC; Department of Haematology, London Hospital, UK.
The incidence of hepatitis and HIV seroconversion has been examined in 64 patients receiving intravenous immunoglobulin (pepsin-treated at pH 4.0) for auto-immune thrombocytopenia. No evidence of HIV seroconversion has been detected. Five patients developed abnormal liver function following treatment. However, in no c
Okpara RA; Akinsete I; Williams EE; Schneider J; Wendler I; Hunsmann G; Department of Haematology, University of Calabar Teaching; Hospital, Nigeria.
Using enzyme-linked immunosorbent assay (ELISA) and confirmatory immunoprecipitation tests, sera from 640 Nigerians from Lagos and Cross River States were examined for antibodies against HIV. These comprised 570 blood donors and their family members, 56 patients with various haematological conditions and 14 patients w
Am J Pathol. 1988 Feb;130(2):411-7. Unique Identifier : AIDSLINE MED/88131267
Dictor M; Andersson C; Department of Pathology, University Hospital, Lund, Sweden.
The histogenesis of Kaposi s sarcoma was investigated by immunohistochemical staining of 20 skin specimens that represented four main histologic stages. The early phase of Stage 1 contained lymphatic-like clefts lined by endothelial cells with thin, discontinuous basement membranes shown by anti-laminin, absent Factor
Ann Intern Med. 1988 Feb;108(2):175-80. Unique Identifier : AIDSLINE MED/88132115
Jackson GG; Paul DA; Falk LA; Rubenis M; Despotes JC; Mack D; Knigge M; Emeson EE; Department of Medicine, University of Illinois College of; Medicine, Chicago.
Infection with human immunodeficiency virus (HIV) may cause viral antigenemia, detected primarily as p24 viral core protein. Among 16 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex studied serially, 12 had or developed antigenemia ranging from 16 to 3006 pg/mL in plasma. The level
Farthing CF; Dalgleish AG; Clark A; McClure M; Chanas A; Gazzard BG; St Stephen's Hospital, London, UK.
Phosphonoformate (PFA; a pyrophosphate analogue) is an effective inhibitor of the reverse transcriptase enzyme in many animal retroviruses. In vitro studies have shown that PFA is also an effective inhibitor of HIV (HTLV III/LAV) at doses readily attainable in vitro. A pilot study was therefore performed with a 3-week
Gaub J; Pedersen C; Poulsen AG; Mathiesen LR; Ulrich K; Lindhardt BO; Faber V; Gerstoft J; Hofmann B; Lernestedt JO; et al; Department of Infectious Diseases, Rigshospitalet, Kobenhavn,; Denmark.
Foscarnet was administered by continuous intravenous infusion in 15 patients with the acquired immunodeficiency syndrome (AIDS) in an open, uncontrolled study. Mean steady state serum concentrations of foscarnet was 261 mumol/l. Treatment was given for 6-21 days, median 14 days, being interrupted prematurely due to re
Prince HE; Arens L; Kleinman SH; Cellular Immunology Laboratory, American Red Cross Blood; Services, Los Angeles/Orange Counties Region, CA 90006.
As part of a larger study to characterize immune alterations in blood donors seropositive for human immunodeficiency virus (HIV), we measured subsets of CD4 (T helper/inducer) and CD8 (T suppressor/cytotoxic) cells by 2-color cytofluorometry. Alterations observed in asymptomatic seropositive donors (ASP) included: 1)
Turner RR; Boone DC; Levine AM; Nichols PW; Parker JW; Department of Medicine, University of Southern California School; of Medicine, Los Angeles 90032.
We have performed lymphocyte phenotypic analysis on serial lymph node biopsies and peripheral blood samples from 11 patients with the persistent generalized lymphadenopathy (PGL) syndrome and correlated the findings with histologic and clinical findings (median follow-up 18 months) in a search for factors that may pre
Bishop PE; McMillan A; Gilmour HM; Department of Genito-Urinary Medicine, University of Edinburgh.
Biopsies of rectal mucosa were taken from 81 men and stained using cytochemical methods for B and T lymphocytes, T cell subsets, immunoglobulin containing plasma cells and mucosal mast cells. The patients studied included human immunodeficiency virus (HIV) infected and non-infected heterosexual and homosexual men, and
Immunol Lett. 1987 Oct;16(1):71-3. Unique Identifier : AIDSLINE MED/88113812
De Paoli P; Carbone A; Battistin S; Crovatto M; Arreghini N; Santini G; Servizio di Microbiologia-Immunologia, Ospedale Civile,; Pordenone, Italy.
We have used 4B4 and 2H4 monoclonal antibodies in conjunction with OKT 4 to quantify T cell subsets in lymph node suspensions from human immunodeficiency virus (HIV) positive subjects with lymphadenopathy syndrome. The data indicate that the reduced OKT 4:OKT 8 ratio was due to a depletion of the OKT 4+ 4B4+ subset. I
A variety of dermatologic disorders have been associated with human immunodeficiency virus (HIV) infection. This prospective study reports the frequency of mucocutaneous findings in 237 individuals at high risk for HIV infection, 33 of whom were HIV seropositive, during a follow-up of 5 to 36 months; 12.1% of the stud
JAMA. 1988 Mar 4;259(9):1353-6. Unique Identifier : AIDSLINE MED/88119436
Lifson AR; AIDS Program, Centers for Disease Control, Atlanta.
Transmission of human immunodeficiency virus (HIV) is known to occur perinatally, through sexual contact, and after exposure to infected blood or blood products. The possibility that breast milk may transmit HIV continues to be evaluated. There is no epidemiologic evidence that contact with saliva, tears, or urine has
Minerva Med. 1987 Dec 31;78(24):1805-12. Unique Identifier : AIDSLINE MED/88123145
Libanore M; Bicocchi R; Raise E; Sighinolfi L; Bedetti A; Montanari P; Fagioli F; Benini A; Schiattone ML; Ghinelli F; et al; Regione Emilia-Romagna U.S.L. n. 31-Arcispedale S. Anna-Ferrara.
Serum zinc levels were assayed in patients with AIDS and related syndromes, using spectrophotometry and atomic absorption. Statistical data have shown that serum zinc levels, in addition to being significantly lower (p less than 0.001) among different groups and controls, decrease progressively with the worsening of t
Aust N Z J Med. 1987 Aug;17(4):371-8. Unique Identifier : AIDSLINE MED/88133648
Garsia RJ; Gatenby PA; Basten A; Kenny DF; Gallagher KJ; Rickard KA; Gust ID; Maskill W; Clinical Immunology Research Centre, University of Sydney, NSW.
One hundred and sixty-one Australian patients with hereditary bleeding disorders comprising hemophilia A (120), hemophilia B (18), von Willebrand s disease (16), and seven symptomatic female hemophilia A or B carriers were screened for clinical and serological evidence of exposure to HTLV-III/LAV/ARV/HIV infection. Du
Rosenblatt JD; Giorgi JV; Golde DW; Ezra JB; Wu A; Winberg CD; Glaspy J; Wachsman W; Chen IS; Department of Medicine, UCLA School of Medicine 90024-1678.
We previously reported isolation of human T-cell leukemia virus II (HTLV-II) from a second patient (N.R.A.) with atypical hairy cell leukemia. Follow-up analysis of the characteristics of the patient s HTLV-II infection over a 2-year period has revealed that the patient had two coexistant lymphoproliferative disorders
Margolick JB; Volkman DJ; Goldstein H; Fauci AS; Department of Environmental Health Sciences, Johns Hopkins; University School of Hygiene and Public Health, Baltimore,; Maryland 21205.
The characteristics of 4 T-cell clones, each capable of producing phagocytosis-inducing factor (PIF), were compared before and after transformation with human T-lymphotropic virus Type 1 (HTLV-I). Before transformation, the four clones produced PIF transiently after stimulation with antigen or mitogen and expressed th
Hooymans JM; Sprenger HG; Weits J; Department of Ophthalmology, University Hospital, Groningen, The; Netherlands.
A 31-year-old homosexual man with AIDS, bilateral cytomegalovirus ( CMV ) retinitis and optic neuritis in one eye, was treated with DHPG. The drug is an acyclic nucleoside analogue of guanosine with antiviral activity. The visu
EMBO J. 1987 Nov;6(11):3379-84. Unique Identifier : AIDSLINE MED/88111526
Shida H; Tochikura T; Sato T; Konno T; Hirayoshi K; Seki M; Ito Y; Hatanaka M; Hinuma Y; Sugimoto M; et al; Institute for Virus Research, Kyoto University, Japan.
The human T-lymphotropic virus type I (HTLV-I) is etiologically linked to adult T-cell leukemia (ATL). To develop a vaccine against ATL, we constructed recombinant vaccinia viruses containing the envelope gene of HTLV-I in the vaccinia virus hemagglutinin (HA) gene, a new site where foreign genes can be inserted. A si
EMBO J. 1987 Dec 1;6(12):3755-60. Unique Identifier : AIDSLINE MED/88111564
Emerman M; Guyader M; Montagnier L; Baltimore D; Muesing MA; Unite d'Oncologie Viral (CNRS UA 1157), Institut Pasteur, Paris,; France.
The recently described human immunodeficiency virus type 2 (HIV2) is significantly divergent in sequence from the more frequently isolated human immunodeficiency virus type 1 (HIV1). Both HIV1 and HIV2 encode a transactivator that is capable of strongly stimulating expression directed by the viral long terminal repeat
Int J Cancer. 1988 Feb 15;41(2):231-8. Unique Identifier : AIDSLINE MED/88114162
Tozawa H; Andoh S; Takayama Y; Tanaka Y; Lee B; Nakamura H; Hayami M; Hinuma Y; Department of Immunology, School of Hygienic Sciences, Kitasato; University, Kanagawa, Japan.
Sixteen monoclonal antibodies (MAbs) against TA34 antigen found on the surface of human T-cell leukemia virus type-I (HTLV-I) infected cells were prepared. These MAbs and one previously prepared anti-TA34 MAb (TAG34) recognized 34-kDa peptide not only in HTLV-I-infected cells, but also in cells infected with simian T-
Okamoto T; Akagi T; Shima H; Miwa M; Shimotohno K; Virology Division, National Cancer Center Research Institute,; Tokyo.
Augmentation of human immunodeficiency virus (HIV) replication in cells infected with HTLVs has been demonstrated by cellular biological studies. Here, evidence is presented that this effect could be ascribed, at least in part, to the level of HIV gene expression.
Bryson YJ; Department of Pediatrics, University of California, School of; Medicine, Los Angeles 90024.
We now have a basis for a more rational approach to rapid evaluation and development of antiviral drugs by screening for activity in vitro, testing for toxicity and efficacy in animals, and clinical testing in humans. Acyclovir is a prototype of this improved process. Interferon
J Immunol. 1988 Feb 1;140(3):779-85. Unique Identifier : AIDSLINE MED/88116691
Lairmore MD; Butera ST; Callahan GN; DeMartini JC; Department of Pathology, College of Veterinary Medicine and; Biomedical Sciences, Fort Collins, CO 80523.
Ovine lentiviruses share genome sequence, structural features, and replicative mechanisms with HIV, the etiologic agent of AIDS. A lamb model of lentivirus-induced lymphoid interstitial pneumonia, comparable to lymphoid interstitial pneumonia associated with pediatric AIDS, was used to investigate production of leukoc
J Immunol. 1988 Feb 1;140(3):941-3. Unique Identifier : AIDSLINE MED/88116716
Evans LA; Homsy JM; Morrow WJ; Gaston I; Sooy CD; Levy JA; Department of Medicine, University of California, School of; Medicine, San Francisco 94143.
Tonsillar B lymphocytes from an asymptomatic individual infected with HIV were transformed with EBV. A cloned lymphoblastoid cell line was obtained that secreted human mAb (IgG4 subtype) against the known gag gene products of 55,000 and 25,000 Da and a protein of 40,000 Da. The latter p40 protein appears to be a HIV g
Grunow R; Jahn S; Porstmann T; Kiessig SS; Steinkellner H; Steindl F; Mattanovich D; Gurtler L; Deinhardt F; Katinger H; et al; Department of Medicine (Charite), Humboldt University Berlin,; G.D.R.
This paper describes the construction of a new heteromyeloma cell line designated CB-F7. The cell line was derived from xenogeneic somatic cell hybridization between normal human B lymphocytes and the murine HAT-sensitive P3X63Ag8/653 cell line. CB-F7 cells were characterized by rapid cell growth (doubling time about
J Med Virol. 1987 Nov;23(3):297-301. Unique Identifier : AIDSLINE MED/88117435
Lelie PN; Reesink HW; Lucas CJ; Central Laboratory of the Netherlands Red Cross Blood Transfusion; Service, Amsterdam.
The efficacy of two heating cycles (90 sec at 103 degrees C and 10 hr at 65 degrees C) used during manufacture of a plasma-derived hepatitis-B vaccine was validated for the inactivation of 12 virus families. A period of 15 min warming up to 65 degrees C had already completely inactivated representatives of nine virus
J Med Virol. 1988 Jan;24(1):109-16. Unique Identifier : AIDSLINE MED/88117439
Tersmette M; Lelie PN; van der Poel CL; Wester MR; de Goede RE; Lange JM; Miedema F; Huisman JG; Central Laboratory of the Netherlands Red Cross Blood Transfusion; Service, Amsterdam.
A recently developed radioimmunoprecipitation assay, using 125I-labeled human immunodeficiency virus (HIV) viral proteins enriched for glycoproteins gp120env, gp41env (GRIPA), was compared to the immunoblot assay with respect to sensitivity and specificity for the detection of antibodies to HIV. Longitudinal sets of s
A total of 135 sera and 18 cerebrospinal fluid (CSF) samples from patients with multiple sclerosis (MS) were screened for antibodies to human T-cell lymphotropic virus type I (HTLV-I) and human immunodeficiency virus (HIV) by ELISA tests. None of the sera or CSF reacted with HIV antigens. Only 3 out of 135 MS sera but
Kamani N; Kennedy J; Brandsma J; Division of Allergy-Immunology, Children's Hospital of; Philadelphia, University of Pennsylvania School of Medicine; 19104.
J Med Primatol. 1987;16(6):373-87. Unique Identifier : AIDSLINE MED/88118836
Murayama Y; Noguchi A; Takenaka O; Primate Research Institute, Kyoto University, Aichi, Japan.
Responses of peripheral blood mononuclear cells to phytohemagglutinin-P (PHA-P), concanavalin-A (ConA), and pokeweed mitogen (PWM) were compared in man and Japanese monkeys. Both CD8+ and CD8- T subsets showed greater responses to ConA than to PHA-P in the Japanese monkey. Addition of macrophages to each T subset prod
Hauber J; Cullen BR; Department of Molecular Genetics, Hoffmann-La Roche Inc., Nutley,; New Jersey 07110.
We used site-directed mutagenesis to delineate sequences within the human immunodeficiency virus type I (HIV-I) long terminal repeat (LTR) required for trans-activation by the viral tat gene product. We demonstrated that sequences 3 to LTR position +44 are dispensable for trans-activation but that almost all of the m
Slamon DJ; Boyle WJ; Keith DE; Press MF; Golde DW; Souza LM; Department of Medicine, University of California, Los Angeles; School of Medicine 90024.
Human T-cell leukemia virus type I is associated with human lymphoid malignancies. The p40xI protein encoded by the x gene of this virus is believed to play some role in virally mediated transformation. This gene is known to encode a transcriptional trans activator which previous studies have shown to be a nuclear pro
Donahue PR; Hoover EA; Beltz GA; Riedel N; Hirsch VM; Overbaugh J; Mullins JI; Department of Cancer Biology, Harvard School of Public Health,; Boston, Massachusetts 02115.
We report the first complete nucleotide sequence (8,440 base pairs) of a biologically active feline leukemia virus (FeLV), designated FeLV-61E (or F6A), and the molecular cloning, biological activity, and env-long terminal repeat (LTR) sequence of another FeLV isolate, FeLV-3281 (or F3A). F6A corresponds to the non-di
JAMA. 1988 Feb 19;259(7):1048-50. Unique Identifier : AIDSLINE MED/88119378
Holmberg SD; Stewart JA; Gerber AR; Byers RH; Lee FK; O'Malley PM; Nahmias AJ; AIDS Program, Centers for Disease Control, Atlanta, GA 30333.
Antibodies to cytomegalovirus ( CMV ), Epstein-Barr virus (EBV), and herpes simplex viruses types 1 and 2 (HSV-1, HSV-2) in three sequential serum samples from 62 men who did and 61 men who did not develop human immunodeficienc
Klin Wochenschr. 1987 Oct 1;65(19):898-905. Unique Identifier : AIDSLINE MED/88120108
Kern W; Kirsten C; Forster P; Diesfeld HJ; Vanek E; Abteilung Innere Medizin III (Hamatologie und Onkologie),; Universitat Ulm.
Sera from 120 patients with rheumatological disorders, neoplastic disease, infectious mononucleosis, and HIV infection, and from 30 healthy blood donors were tested for nonspecific reactivity in 13 routinely used parasite serological tests. Responses were detected in 3/30 healthy blood donors (10%) vs 25/120 patients
Nature. 1988 Jan 7;331(6151):76-8. Unique Identifier : AIDSLINE MED/88122540
Fisher RA; Bertonis JM; Meier W; Johnson VA; Costopoulos DS; Liu T; Tizard R; Walker BD; Hirsch MS; Schooley RT; et al; Biogen Research Corporation, Cambridge, Massachusetts 02142.
The T-cell surface glycoprotein, CD4 (T4), acts as the cellular receptor for human immunodeficiency virus, type 1 (HIV-1), the first member of the family of viruses that cause acquired immunodeficiency syndrome. HIV recognition of CD4 is probably mediated through the virus envelope glycoprotein (gp120) as shown by co-
Nature. 1988 Jan 7;331(6151):78-81. Unique Identifier : AIDSLINE MED/88122541
Hussey RE; Richardson NE; Kowalski M; Brown NR; Chang HC; Siliciano RF; Dorfman T; Walker B; Sodroski J; Reinherz EL; Laboratories of Immunobiology, Dana-Farber Cancer Institute,; Boston, Massachusetts 02115.
The CD4 (T4) molecule is expressed on a subset of T lymphocytes involved in class II MHC recognition, and is probably the physiological receptor for one or more monomorphic regions of class II MHC (refs 1-3). CD4 also functions as a receptor for the human immunodeficiency virus (HIV) exterior envelope glycoprotein (gp
Nature. 1988 Jan 7;331(6151):84-6. Unique Identifier : AIDSLINE MED/88122543
Traunecker A; Luke W; Karjalainen K; Basel Institute for Immunology, Switzerland.
Human immunodeficiency virus (HIV) infection can bring about total collapse of the immune system by infecting helper T lymphocytes which express CD4, the molecule which mediates interaction between the cell surface and viral envelope glycoprotein gp120 (refs 3-10). HIV apparently escapes the effects of neutralizing an
Nature. 1988 Feb 11;331(6156):540-3. Unique Identifier : AIDSLINE MED/88122645
Jacobson S; Raine CS; Mingioli ES; McFarlin DE; Neuroimmunology Branch, National Institute of Neurological and; Communicative Disorders and Stroke, Bethesda, Maryland 20892.
Tropical spastic paraparesis (TSP) is a slowly progressive myelopathy associated with increased serum and cerebrospinal fluid antibodies to the human T-lymphotropic retrovirus type I (HTLV-I) (ref. 1), and has been observed in many regions of the world. A similar condition known as HTLV-I-associated myelopathy occurs
Sillman FH; Sedlis A; Department of Obstetrics and Gynecology, State University of New; York Health Science Center at Brooklyn.
People with deficient cell-mediated immunity have an increased susceptibility to viral infections and certain cancers, particularly large cell lymphomas and cancers of the skin and anogenital region. All are linked to viral origins. Neoplasms in the immunodeficient patient often occur at a relatively young age, involv
Grossniklaus HE; Frank KE; Tomsak RL; Division of Ophtalmology, University Hospitals of Cleveland, Case; Western Reserve University, OH 44106.
A 33-year-old man with acquired immune deficiency syndrome (AIDS) was found to have bilateral cytomegalovirus ( CMV ) retinitis with concomitant unilateral optic neuritis. The patient died and postmortem examination of both eye
Schiodt M; Lackner A; Armitage G; Lerche N; Greenspan JS; Lowenstine L; Department of Stomatology, University of California, San; Francisco.
Simian acquired immunodeficiency syndrome (SAIDS) is a retrovirus-induced immunodeficiency disease that affects certain nonhuman primates and has many parallels to human AIDS. We examined 72 rhesus monkeys (Macaca mulatta) exposed to SAIDS retrovirus serotype-1 (SRV-1) and 81 healthy control monkeys at the California
Proc Natl Acad Sci U S A. 1988 Jan;85(2):334-8. Unique Identifier : AIDSLINE MED/88124836
Rekosh D; Nygren A; Flodby P; Hammarskjold ML; Wigzell H; Department of Biochemistry, State University of New York, Buffalo; 14214.
A Sal I-Xho I fragment containing the genes encoding tat, art, and the envelope proteins from the BH10 clone of human immunodeficiency virus (HIV) was inserted into a simian virus 40 (SV40)-based eukaryotic expression vector. The vector is a shuttle vector that replicates to high copy numbers in both Escherichia coli
Proc Natl Acad Sci U S A. 1988 Feb;85(3):900-4. Unique Identifier : AIDSLINE MED/88124948
Aloia RC; Jensen FC; Curtain CC; Mobley PW; Gordon LM; Anesthesiology Service, J. L. Pettis Memorial Veterans; Administration Hospital, Loma Linda, CA 92357.
Lipid analyses of the human immunodeficiency virus (HIV) propagated in Hut 78 cells indicated a low total lipid/protein ratio, a high cholesterol/phospholipid molar ratio, and major phospholipids consisting of phosphatidylcholine, phosphatidylethanolamine, sphingomyelin, and phosphatidylserine; comparable lipid profil
De la Barrera S; Fejes M; Riera NE; Scaglione C; Perez Blanco R; de Bracco MM; Instituto de Investigaciones Hematologicas, Academia Nacional de; Medicina, Buenos Aires, Argentina.
Serologic reactivity against EBV-infected lines was assayed in patients with AIDS (n = 4) or the AIDS related complex (AIDS-RC) (n = 46) residing in Argentina . Anti-VCA serology was comparable to that of controls. However sera from AIDS and AIDS-RC could induce antibody dependen
Lundin K; Karlsson A; Nygren A; Lofstrom A; Gigliotti D; Wigzell H; Department of Immunology, Karolinska Institute, Stockholm,; Sweden.
HIV+ human sera contain antibodies against most HIV proteins, including the envelope glycoprotein Gp120. Some of these antibodies may have an epitope that sterically resembles the CD4 region to which the Gp120 molecule binds. Amongst 58 HIV+ sera tested, we found three with the capacity to block the binding of anti-CD
A photodynamic method has been evaluated as a means of eradicating viral contaminants with the potential for rendering blood safe for transfusion. Herpes simplex virus type 1 (HSV-1) was tested under flowing conditions in culture media or in blood supplemented with the virus. Hematoporphyrin derivative was used as the
Hsiung GD; Virology Reference Laboratory, Veterans Administration Medical; Center, West Haven, Connecticut 06516.
In 1911, the first retrovirus was described: the Rous sarcoma virus, an avian retrovirus. Forty years later the murine leukemic virus, a mouse retrovirus, was reported. Although many other retroviruses from non-primate species were identified during the 1960s, the first primate retrovirus was not recognized until it w
Booss J; Harris SA; Neurology Service, VA Medical Center, West Haven, CT 06516.
Infection with the AIDS virus itself (HIV, HTLV-III, LAV, ARV) is associated with a full spectrum of neurological disorders. The application of diagnostic studies for HTLV-III infection has demonstrated that these neurologic disorders can be the first manifestation of AIDS or occur in the absence of AIDS. The most com
Roy G; Pardo A; Leyva-Cobian F; Department of Immunology, Centro Ramon y Cajal, Madrid, Spain.
The phenotype and functions of monocytes in patients with haemophilia A and age-matched controls were studied. Fourteen male haemophiliacs were classified in three categories according to the mean number of units of factor VIII received during the last 5 years. Eleven patients were positive for antibodies to human imm
Ann Intern Med. 1988 Feb;108(2):199-203. Unique Identifier : AIDSLINE MED/88132120
Blanche S; Le Deist F; Veber F; Lenoir G; Fischer AM; Brochier J; Boucheix C; Delaage M; Griscelli C; Fischer A; Unite d'Immunologie and Hematologie, Hopital Necker-Enfants; Malades, Paris, France.
We treated two children who developed Epstein-Barr virus-induced polyclonal B-cell proliferation after HLA-mismatched bone marrow transplantation for congenital immunodeficiency with two monoclonal anti-B-cell antibodies. Lymphoproliferative syndrome occurred between 50 and 60 days after bone marrow infusion, and was
Ann Intern Med. 1988 Mar;108(3):328-33. Unique Identifier : AIDSLINE MED/88132157
Smith PD; Lane HC; Gill VJ; Manischewitz JF; Quinnan GV; Fauci AS; Masur H; Laboratory of Microbiology and Immunology, National Institute of; Dental Research, Bethesda, Maryland.
STUDY OBJECTIVE: To determine the frequency of pathogenic gastrointestinal microorganisms in patients with the acquired immunodeficiency syndrome (AIDS) and diarrhea, and to determine if treatment for identifiable microorganisms improves symptoms. DESIGN: Prospective, consecutive sample study. Setting: Referral-based
Ann Med Interne (Paris). 1987;138(6):411-5. Unique Identifier : AIDSLINE MED/88132214
Girard PM; Marche C; Maslo C; Rene E; Leport J; Matheron S; Michon C; Coulaud JP; Saimot AG; Service de Maladies Infectieuses et Tropicales, Hopital; Claude-Bernard, Paris.
Digestive manifestations of AIDS were studied retrospectively in 87 patients with respect to clinical, microbiological, endoscopic and histological data. Chronic or intermittent diarrhea was observed in 62 p. 100 of patients and frequently associated with major weight loss. The digestive opportunistic infections were:
Nakashima H; Kido Y; Kobayashi N; Motoki Y; Neushul M; Yamamoto N; Department of Virology and Parasitology, Yamaguchi University; School of Medicine, Japan.
A new reverse transcriptase (RT) inhibitor was extracted and purified from the red alga Schizymenia pacifica. The chromatographic behavior and chemical properties of this sea algal extract (SAE) suggest that it is a sulfated polysaccharide having a molecular weight of approximately 2,000,000. SAE is composed of galact
Synthesis of peptides corresponding to the 201-210 and 200-206 sequences of p28sis oncoprotein is reported. This region of the oncoprotein was chosen as a probable epitope basing on the analysis of its secondary structure and hydrophilicity profile. The synthesis was carried out by classical method in solution using s
Brindle RJ; Eglin RP; Parsons AJ; Hill AV; Selkon JB; Public Health Laboratory, John Radcliffe Hospital, Oxford.
Blood samples from 13 locations in the Pacific and South-East Asia were tested for evidence of infection with human T-cell lymphotropic virus type-1 (HTLV-1), human immunodeficiency virus (HIV-1), hepatitis B virus (HBV) and hepatitis delta virus (HDV). No samples were positive for antibody to HIV-1. Antibodies to HTL
Ohtsu T; Tsugane S; Tobinai K; Shimoyama M; Nanri S; Watanabe S; Department of Internal Medicine, National Cancer Center Hospital,; Tokyo.
This study was performed to estimate human T-cell leukemia-lymphoma virus type-I (HTLV-I) infection and human immunodeficiency virus (HIV) infection in Japanese immigrant colonies in Bolivia , where no seroepidemiological study of HTLV-I or HIV has ever been reported, among 647 hea
Tanaka Y; Shirakawa F; Oda S; Chiba S; Suzuki H; Eto S; Yamashita U; First Department of Internal Medicine, University of Occupational; and Environmental Health, School of Medicine, Kitakyushu.
The immunosuppressive activity of sera from adult T cell leukemia (ATL) patients and culture supernatants of ATL cells and ATL cell lines on B cell responses was examined in vitro. ATL sera and culture supernatants of ATL cells suppressed B cell proliferative and differentiative responses induced with B cell mitogens
Nishimura M; Akiguchi I; Takigawa M; Fujita M; Kameyama M; Maeda M; Department of Neurology, Faculty of Medicine, Kyoto University,; Japan.
T cell lines were established from the cerebrospinal fluid (CSF) lymphocytes of two patients with human T lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM). These two interleukin-2 ( IL-2 )-dependent T cell lines have been cultured for more than 8 months wit
Levitt LJ; Reyes GR; Moonka DK; Bensch K; Miller RA; Engleman EG; Department of Medicine, Stanford University Medical Center,; California 94305.
Human retroviruses have recently been linked with T cell lymphoproliferative disorders and with the acquired immune deficiency syndrome. We investigated the mechanisms for acquired pure red cell aplasia and cutaneous anergy in a patient with the chronic T gamma-lymphoproliferative disease (T gamma-LPD) syndrome. Patie
Sacchi N; de Klein A; Showalter SD; Bigi G; Papas TS; Laboratory of Molecular Oncology, National Cancer Institute,; Frederick, Maryland 21701-1013.
The cellular ets-1 gene homologous to the 5 region of the v-ets sequence of the E26 retrovirus codes for a 6.8-kb mRNA that is translated into a 51-kDa protein in human cells. A survey of mRNA from human tissues showed the thymus as the tissue with the highest level of ets-1 transcription, within other hematopoietic
Lancet. 1988 Feb 6;1(8580):259-62. Unique Identifier : AIDSLINE MED/88120767
Nelson JA; Wiley CA; Reynolds-Kohler C; Reese CE; Margaretten W; Levy JA; Department of Immunology, Research Institute of Scripps Clinic,; La Jolla, California 92037.
Infectious human immunodeficiency virus (HIV) was recovered from two out of four bowel biopsy specimens from acquired immunodeficiency syndrome (AIDS) patients with chronic diarrhoea of unknown aetiology. In-situ hybridisation of biopsy specimens from rectum and duodenum of other AIDS patients with gastrointestinal co
Lancet. 1988 Feb 20;1(8582):373-6. Unique Identifier : AIDSLINE MED/88120875
de Wolf F; Lange JM; Goudsmit J; Cload P; de Gans J; Schellekens PT; Coutinho RA; Fiddian AP; van der Noordaa J; Department of Virology, University of Amsterdam, Netherlands.
18 men with longstanding human immunodeficiency virus (HIV) antigenaemia but no symptoms received zidovudine in low-dose regimens (250 mg 6-hourly, 500 mg 6-hourly, or 500 mg 12-hourly) with or without acyclovir. Serum HIV antigen rose in only 1 patient and declined significantly in 13 (to below cut-off values in 9).
Anand R; Moore J; Jaffe H; Feorino P; Weinstein R; Curran J; Srinivasan A; AIDS Program, Center for Infectious Diseases, Atlanta, Georgia; 30333.
Structural heterogeneity in human immunodeficiency virus (HIV-1) isolates from different sources has been reported. In order to investigate if the virus exhibits heterogeneity in vivo, HIV-1 was isolated over a 3 year period (1983-1985) from a blood donor who progressed from the asymptomatic carrier state to frank AID
Nature. 1988 Feb 18;331(6157):619-22. Unique Identifier : AIDSLINE GENBANK/Y00294
Kestler HW 3d; Li Y; Naidu YM; Butler CV; Ochs MF; Jaenel G; King NW; Daniel MD; Desrosiers RC; New England Regional Primate Research Center, Harvard Medical; School, Southborough, Massachusetts 01772.
Information on the extent of genetic variability among non-human primate lentiviruses related to human immunodeficiency virus (HIV) is sorely lacking. Here we describe the isolation of two molecular clones from the simian immunodeficiency virus (SIV) and their use to derive restriction endonuclease maps of five SIV is
Science. 1988 Feb 19;239(4842):906-10. Unique Identifier : AIDSLINE GENBANK/M18246
Overbaugh J; Donahue PR; Quackenbush SL; Hoover EA; Mullins JI; Department of Cancer Biology, Harvard School of Public Health,; Boston, MA 02115.
A replication-defective variant of feline leukemia virus was molecularly cloned directly from infected tissue and found to induce a rapid and fatal immunodeficiency syndrome in cats. Studies with cloned viruses also showed that subtle mutational changes would convert a minimally pathogenic virus into one that would in
Hirose S; Kotani S; Uemura Y; Fujishita M; Taguchi H; Ohtsuki Y; Miyoshi I; Department of Medicine, Kochi Medical School, Japan.
The mode of vertical transmission of human T-cell leukemia virus type I (HTLV-I) was investigated by foster-nursing in rabbits. Two of five rabbits born to noninfected mothers and fostered by virus-infected females seroconverted for HTLV-I after 7 weeks, whereas all seven rabbits born to virus-infected mothers and fos
Madden DL; Tzan NR; Roman GC; Detels R; Mundon FK; Fuccillo DA; Sever JL; Infectious Disease Branch, National Institute of Neurological and; Communicative Disorders and Stroke, Bethesda, Maryland 20892.
To investigate the possible occurrence of human immunodeficiency virus (HIV) or human T-cell lymphotropic virus, type I (HTLV-I) infections in the United States prior to 1979-1981, when acquired immune deficiency syndrome (AIDS) was first recognized, we tested sera from 310 pregnant wo
Raphael M; Binet JL; Department of Hematology, CHU Pitie-Salpetriere, Paris,; France.
The present nosography of lymphoproliferative disorders is continuously in progression. Until now, a number of data regarding cytomorphological, cytochemical, immunological and molecular biological findings demonstrated importance in diagnostic and prognostic evaluation.
Yodoi J; Tagaya Y; Okada M; Taniguchi Y; Hirata M; Naramura M; Maeda M; Institute for Immunology, Faculty of Medicine, Kyoto University,; Japan.
The expression of the interleukin-2 receptor (IL-2-R) is regulated by transcriptional and post-transcriptional mechanisms. IL-2-R gene expression is induced by pharmacological agents including calcium ions, phorbol esters such as phorbol myristate acetate (PMA) and forskolin (FK), a direct activator of adenylate cycla
Am J Epidemiol. 1988 Mar;127(3):532-9. Unique Identifier : AIDSLINE MED/88130977
Reeves WC; Saxinger C; Brenes MM; Quiroz E; Clark JW; Hoh MW; Blattner WA; Division of Epidemiology, Gorgas Memorial Laboratory, Panama.
Human T-cell lymphotropic virus type I (HTLV-I) infection and associated hematologic malignancies cluster in Japan , the Caribbean basin, and Central Africa. The authors believe that this study of HTLV-I seroepidemiology in the Republic of Panama is the first detailed analytic study
Am J Hematol. 1988 Feb;27(2):142-3. Unique Identifier : AIDSLINE MED/88131005
Matsuoka T; Tamura H; Fujishita M; Kubonishi I; Taguchi H; Miyoshi I; Department of Medicine, Kochi Medical School, Japan.
Thrombocytopenic purpura developed in a 64-year-old woman seropositive for human T-cell leukemia virus type I (HTLV-I). She had no underlying disorders and HTLV-I is suggested as a possible cause of her thrombocytopenia.
Ann Med Interne (Paris). 1987;138(6):419-21. Unique Identifier : AIDSLINE MED/88132216
Saimot AG; Girard PM; Brun-Vezinet F; Bartczak S; Rey MA; Coulaud JP; Service de Pathologie Infectieuse et Tropicale/INSERM U13,; Hopital Claude-Bernard, Paris.
A case of AIDS due to HIV/LAV2 is reported. The patient was a 32 year old man from Guinea-Bissau with no known risk factors. He had brain toxoplasmosis, oral thrush and chronic genital herpes . Investi
In: Feldman, Douglas A.; Johnson, Thomas M., eds. The Social Dimensions of AIDS: Method and Theory. New York: Praeger, 1986 :163-178. Unique Identifier : AIDSLINE KIE/24450
In: Feldman, Douglas A.; Johnson, Thomas M., eds. The Social Dimensions of AIDS: Method and Theory. New York: Praeger, 1986 :179-194. Unique Identifier : AIDSLINE KIE/24451
In: Feldman, Douglas A.; Johnson, Thomas M., eds. The Social Dimensions of AIDS: Method and Theory. New York: Praeger, 1986 :227-232. Unique Identifier : AIDSLINE KIE/24452
In: Feldman, Douglas A.; Johnson, Thomas M., eds. The Social Dimensions of AIDS: Method and Theory. New York: Praeger, 1986 :235-243. Unique Identifier : AIDSLINE KIE/24453
In: Feldman, Douglas A.; Johnson, Thomas M., eds. The Social Dimensions of AIDS: Method and Theory. New York: Praeger, 1986 :245-259. Unique Identifier : AIDSLINE KIE/24454
Federal Supplement. 1986 Sep 19 (date of decision);645:84-89. Unique Identifier : AIDSLINE KIE/24643
In 1986, the District of Columbia Council enacted a law prohibiting health, life, and disability insurers from denying insurance coverage to individuals who have tested positively for AIDS or AIDS-related complex (ARC), or who have refused to take such a test. The Act also imposed a five-year moratorium on the use of
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