Trisomy 12 in Burkitt-like lymphoma associated with acquired immunodeficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

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Trisomy 12 in Burkitt-like lymphoma associated with acquired immunodeficiency syndrome.

Cancer Genet Cytogenet. 1987 Dec;29(2):245-51. Unique Identifier : AIDSLINE MED/88052534
Kosmo MA; Mitsuyasu RT; Sparkes RS; Gale RP; Department of Medicine, UCLA School of Medicine 90024.

Abstract: Cytogenetic abnormalities have been reported in lymphoproliferative disorders, the most common of which is the t(8;14) translocation in Burkitt and Burkitt-like lymphomas. We report a 30-year-old homosexual male with Burkitt-like lymphoma and trisomy 12. This patient presented with persistent generalized lymphadenopathy and subsequently developed advanced lymphoma. Cell surface markers revealed a monoclonal pattern containing mu heavy chain and kappa light chain immunoglobulins. Cytogenetic analysis of bone marrow involved with lymphoma revealed an additional chromosome #12. Mitogen-stimulated cultures of peripheral blood showed a normal 46,XY karyotype. Trisomy 12 has been found in chronic lymphocytic leukemia and in other low-grade B-cell lymphoproliferative disorders, but not in Burkitt-like lymphoma.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult Bone Marrow/PATHOLOGY Burkitt's Lymphoma/COMPLICATIONS/*GENETICS/PATHOLOGY Case Report *Chromosomes, Human, Pair 12 Human Karyotyping Male Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. *Trisomy JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcomplicationsadultbonemarrow/pathologyburkitt'slymphoma/complications/KWDgenetics/pathologycasereportKWDchromosomes,human,pair12humankaryotypingmalesupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDs
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