Elevated plasma glutamate levels in colorectal carcinoma patients and in patients with acquired immunodeficiency syndrome (AIDS). NLM AIDSLINE Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

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Elevated plasma glutamate levels in colorectal carcinoma patients and in patients with acquired immunodeficiency syndrome (AIDS).

Immunobiology. 1987 Aug;174(4-5):473-9. Unique Identifier : AIDSLINE MED/88057118
Droge W; Eck HP; Betzler M; Naher H; Institute of Immunology and Genetics, German Cancer Research; Center, Heidelberg.

Abstract: Amino acid concentrations were analyzed in the sera of HIV (LAV/HTLV-III) positive persons and in the plasma of colorectal carcinoma patients. Both groups of persons showed significantly elevated glutamate concentrations when compared with healthy control persons. Glutamate concentrations were found to be strongly elevated in all groups of HIV-positive persons including patients with acquired immunodeficiency syndrome (AIDS) or lymphadenopathy as well as HIV-positive persons without overt symptoms, indicating that increased plasma glutamate levels may be among the earliest consequences of the HIV infection. Moreover, the increased plasma glutamate concentrations in the colorectal carcinoma patients were correlated with a decreased immunological reactivity (mitogenic responses against concanavalin A). This suggests the possibility that the increased plasma glutamate concentrations may be causally responsible for the decreased immunological reactivity in colorectal carcinoma patients as well as in patients with AIDS.
Keywords: Acquired Immunodeficiency Syndrome/*ENZYMOLOGY/IMMUNOLOGY Carcinoma/*BLOOD/IMMUNOLOGY Colonic Neoplasms/*BLOOD/IMMUNOLOGY Comparative Study Glutamates/*BLOOD Human Lymphocyte Transformation Male Rectal Neoplasms/*BLOOD/IMMUNOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDenzymology/immunologycarcinoma/KWDblood/immunologycolonicneoplasms/KWDblood/immunologycomparativestudyglutamates/KWDbloodhumanlymphocytetransformationmalerectalneoplasms/KWDblood/immunologyjournalarticle
880330
M8830375

Copyright © 1988 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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