[New York, NY] : Published for the Milbank Memorial Fund by Cambridge University Press, [c1986] 182 p. : ill (The Milbank quarterly, ISSN 0887-378X ; v. 64, suppl. 1) Unique Identifier : AIDSLINE CAT/8801264
Progress in Immunology VI. Sixth International Congress of Immunology. Cinader B, Miller RG, eds. New York, Academic Press, p. 949-60, 1986.. Unique Identifier : AIDSLINE ICDB/88640053
Margolick JB; Fauci AS; Dept. of Environmental Health Sciences, The Johns Hopkins Sch. of; Hygiene and Public Health, Baltimore, MD 21205
The immunopathogenesis of acquired immunodeficiency syndrome (AIDS) is reviewed under the following headings: quantitative T lymphocyte deficiency, qualitative abnormalities of T lymphocytes, inhibition of CD4+ cell function, activated T cells and cofactors in the pathogenesis of AIDS, abnormalities in B lymphocytes a
The Biology of the Interferon System 1986. Cantell K, Schellekens H, eds. Boston, Martinus Nijhoff Publishers, 579 p., 1987.. Unique Identifier : AIDSLINE ICDB/88638655
Anonymous; No affiliation given
This volume presents proceedings of the 1986 ISIR-TNO (International Society for Interferon Research-Nederlandse Centrale Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek) meeting on the interferon (IFN) system, held September 7-12, 1986 in Espoo,
The studies contained in this dissertation were undertaken to elucidate salient aspects of the biology and pathogenic processes of the human T-lymphotropic retroviruses. Studies directed at the mechanism of lymphocyte transformation by human T-lymphotropic virus type I (HTLV-I) (the etiologic agent of adult T-cell leu
The Basic Science of Oncology. Tannock IF, Hill RP, eds. New York, Pergamon Press, p. 52-71, 1987.. Unique Identifier : AIDSLINE ICDB/88639527
Sheinin R; Mak TW; Clark SP; Dept. of Microbiology, Univ. of Toronto, Toronto, Ontario, Canada
Experimental methods of cancer virology and characteristics of DNA and RNA tumor viruses are reviewed. Topics include in vivo assay for tumor viruses, viral infection, in vitro assays, families of tumor viruses, integration of viral DNA, expression of viral genes, human tumors and viruses, specific DNA viruses, charac
Important Advances in Oncology 1987 is the third in a series of annual volumes, each of which contains the most significant changes in oncologic research and practice that have taken place during the preceding year. For this volume, basic research has been selected that describes studies related to immunoglobulin and
Dev Oncol; 44:309-19 1987. Unique Identifier : AIDSLINE ICDB/88639589
Grandori C; Graziani G; Perno CF; D'Onofrio C; Bonmassar E; Dept. of Experimental Medicine and Biochemical Science, Second; Univ. of Rome, Via Orazio Raimondo, I-00173 Rome, Italy
Ficoll-separated mononuclear cells from human umbilical cord blood (cord blood lymphocytes, CBL) or adult peripheral blood were treated with human beta interferon (IFN: 1,000 U/ml) or PCF-39 (N-9 arginil hypoxanthine derivative, 1 or 100 ug/ml) for 16 hr at 37 C. Cells were then tested for cell mediated-natural cytoto
Progress in Immunology VI. Sixth International Congress of Immunology. Cinader B, Miller RG, eds. New York, Academic Press, p. 553-62, 1986.. Unique Identifier : AIDSLINE ICDB/88640034
Anti-Tac, a monoclonal antibody that recognizes the interleukin-2 ( IL-2 ) receptor, was used to (1) characterize the human IL-2 receptor; (2) molecularly clone cDNA for the human IL-2 receptor peptide; (3) define lymphocyte functions that require interaction of IL-2 wit
Hosp Mater Manage. 1987 Oct;12(10):3-6. Unique Identifier : AIDSLINE AHA/88059327
Brightbill TC
In this issue HMM examines the impact of AIDS on the price and availability of disposable gloves. Materials managers are facing higher prices and uncertain supplies as more and more health care workers use gloves and other protective apparel.
Spec Law Dig Health Care (Mon). 1987 Dec;9(6):7-28. Unique Identifier : AIDSLINE AHA/88071016
Greif RC
As AIDS contagion spreads at epidemic proportions, and fear of the fatal disease runs rampant, it is noteworthy to recognize the legal impacts of the disease, especially as they affect the health care profession. Hospitals and blood banks face potentially unlimited liability if found legally responsible for transmitti
Cancer. 1987 Dec 1;60(11):2801-5. Unique Identifier : AIDSLINE MED/88052473
Constantino A; West TE; Gupta M; Loghmanee F; Department of Medicine, State University of New York at Buffalo.
A 34-year-old male prisoner with a history of intravenous drug abuse presented with fever, lymphadenopathy, weight loss, and recent onset of congestive heart failure. Serologic testing was positive for antibodies to human immune deficiency virus. There was intense myocardial uptake of gallium. Autopsy showed a primary
Cancer Genet Cytogenet. 1987 Dec;29(2):245-51. Unique Identifier : AIDSLINE MED/88052534
Kosmo MA; Mitsuyasu RT; Sparkes RS; Gale RP; Department of Medicine, UCLA School of Medicine 90024.
Cytogenetic abnormalities have been reported in lymphoproliferative disorders, the most common of which is the t(8;14) translocation in Burkitt and Burkitt-like lymphomas. We report a 30-year-old homosexual male with Burkitt-like lymphoma and trisomy 12. This patient presented with persistent generalized lymphadenopat
Biggar RJ; Environmental Epidemiology Branch, National Cancer Institute,; Bethesda, Maryland 20892.
This review summarizes observations about the distribution of AIDS and HIV infection throughout the world. The United States has reported the greatest number of cases to the World Health Organization (WHO), but data from many areas are lacking or incomp
Gal AA; Evans S; Meyer PR; Department of Pathology and Laboratory Medicine, Los Angeles; County--University of Southern California School of Medicine.
The medical and laboratory records were reviewed in 37 acquired immunodeficiency syndrome (AIDS) patients with cryptococcal infections. In 24 patients with the presentation of cryptococcal meningitis, the initial cerebrospinal fluid (CSF) culture was positive. The initial India ink
Hostettler C; Amundson D; O'Connor S; Pharmacy Department, Naval Hospital, San Diego, CA 92134.
Acquired immunodeficiency syndrome (AIDS), with its attendant sequelae of opportunistic infections and aggressive lymphatic malignancies, continues to dominate the world s medical literature. Pneumocystis carinii pneumonia (PCP) remains as the most commonly encountered infection in AIDS and an early cause of morbidity
Estrin HM; Farhi DC; Ament AA; Yang P; Department of Medicine, University Hospitals, Case Western; Reserve University School of Medicine, Cleveland, Ohio.
Biggs BA; Crowe SM; Lucas CR; Ralston M; Thompson IL; Hardy KJ; Fairfield Infectious Diseases Hospital, Victoria, Australia.
Gastrointestinal Kaposi s sarcoma is a well described and usually asymptomatic manifestation of the acquired immune deficiency syndrome. We report a patient who had extensive colonic Kaposi s sarcoma and presented with an ulcerative colitis like illness. Total colectomy was subsequently required as an emergency proced
Paul RG; Roodman ST; Paul DA; Perrillo RP; Gastroenterology Section, Veterans Administration Medical Center,; St. Louis.
The density of HLA Class I antigen on peripheral blood mononuclear cells was evaluated by flow cytometry in the following groups of patients: 41 HBsAg carriers; 12 individuals with chronic non-A, non-B hepatitis, and 4 with acute hepatitis B. Fourteen of the carriers were positive for antibody to human immunodeficienc
Kim KK; Factor SM; Department of Pathology, Albert Einstein College of Medicine,; Bronx, NY 10461.
A 40-year-old homosexual man with the acquired immunodeficiency syndrome (AIDS) presented with dyspnea and renal insufficiency. A chest radiograph showed cardiomegaly and prominent pulmonary arteries, without alveolar infiltrates. Swan-Ganz catheterization revealed pulmonary hypertension and no evidence of left-to-rig
Droge W; Eck HP; Betzler M; Naher H; Institute of Immunology and Genetics, German Cancer Research; Center, Heidelberg.
Amino acid concentrations were analyzed in the sera of HIV (LAV/HTLV-III) positive persons and in the plasma of colorectal carcinoma patients. Both groups of persons showed significantly elevated glutamate concentrations when compared with healthy control persons. Glutamate concentrations were found to be strongly ele
Matis WL; Triana A; Shapiro R; Eldred L; Polk BF; Hood AF; Department of Dermatology, Johns Hopkins University School of; Medicine, Baltimore, MD 21205.
Both human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) are associated with an increased prevalence of several dermatologic diseases. We studied healthy homosexual men with negative reactivity to HIV antibody, homosexual men without AIDS but with positive reactivity to HIV antib
Mayer-da-Silva A; Stadler R; Imcke E; Bratzke B; Orfanos CE; Department of Dermatology, University Medical Center Steglitz,; Free University of Berlin, F.R.G.
Lesions (n = 19) of cutaneous Kaposi s sarcoma in different stages of development were obtained from 13 patients with acquired immunodeficiency syndrome (AIDS), and studied by light and electron microscopy. Six additional biopsies from 4 patients treated with recombinant alpha A interferon were obtained after treatmen
Conte JE Jr; Upton RA; Lin ET; School of Medicine, University of California, San Francisco; 94143-0208.
In patients with normal renal function, pentamidine elimination half-life and plasma clearance (mean +/- SD) were 6.22 +/- 1.17 hr and 411 +/- 55 liters/hr, respectively. With creatinine clearances from 35 to 145 ml/min, neither the elimination half-life (P = .47) nor the plasma clearance (P = .40) was correlated with
Bouton RA; Gallaher PE; Garlinghouse PA; Leal T; Rosenstein LD; Young RK; Department of Psychology, University of Texas, Austin 78713.
Two scales, one for measuring attitudes toward the fear of Acquired Immune Deficiency Syndrome (AIDS) and one for measuring attitude toward homosexuality, were constructed using Thurstone s method of equal-appearing intervals. After construction, the scales were given to 528 students at the University of Texas at Aust
A five-amino-acid (TDNYT) sequence of vasoactive intestinal polypeptide (VIP) shares homology with the proposed attachment sequences of the human immunodeficiency virus (HIV). Synthetic peptides with these sequences have previously been shown to block viral envelope (gp120) binding and HIV infectivity and to serve as
JAMA. 1987 Dec 18;258(23):3395-7. Unique Identifier : AIDSLINE MED/88063120
Handsfield HH; Cummings MJ; Swenson PD; Seattle-King County Department of Public Health, WA.
The prevalence of hepatitis B surface antigen (HBsAg) and antibody to human immunodeficiency virus (HIV) was determined in serum or plasma specimens of 506 patients submitted to the clinical chemistry laboratory of an urban teaching hospital, and the results were correlated with biohazard warning labels on the specime
Dusheiko G; Paterson A; Department of Medicine, University of the Witwatersrand Medical; School, Johannesburg, South Africa.
The interrelationship between hepatitis B virus (HBV) infection, hepatic injury and clinical activity in chronic HBV infection is incompletely understood. We have scored histologic activity, the expression of hepatitis B core (HBcAg) and hepatitis B surface antigen (HBsAg) and assessed HBV replication to correlate HBV
Nature. 1987 Nov 26-Dec 2;330(6146):388-91. Unique Identifier : AIDSLINE MED/88065860
Gonda MA; Braun MJ; Carter SG; Kost TA; Bess JW Jr; Arthur LO; Van der Maaten MJ; Laboratory of Cell and Molecular Structure, National Cancer; Institute-Frederick, Maryland 21701.
An infectious virus which causes persistent lymphocytosis, lymphadenopathy, lesions in the central nervous system (CNS), progressive weakness and emaciation was previously isolated from the leukocytes of cattle. Our present studies show that this virus encodes a reverse transcriptase (RT) with Mg2+ cation preference,
Pathol Res Pract. 1987 Oct;182(5):658-68. Unique Identifier : AIDSLINE MED/88068071
Hashimoto H; Muller H; Falk S; Stutte HJ; Senckenbergisches Zentrum der Pathologie, Universitat; Frankfurt/M, Federal Republic of Germany.
Twenty-one cases (25 biopsies including 9 frozen biopsies) of Kaposi s sarcoma associated with the acquired immune deficiency syndrome (AIDS) were examined immunohistochemically, lectin-histochemically, and enzyme histochemically to ascertain the histogenesis of the lesion. The Kaposi s sarcomas were histologically su
Joshi VV; Pawel B; Connor E; Sharer L; Oleske JM; Morrison S; Marin-Garcia J; Department of Pathology, Children's Hospital of New Jersey,; Newark 07107.
Pathologic features of the arteries of different organs (heart, lungs, kidneys, spleen, intestine, brain) seen at autopsy in 6 children with acquired immune deficiency syndrome (AIDS) are described. Small and medium-sized arteries, which were the most commonly involved, showed intimal fibrosis with fragmentation of el
Haas JG; Riethmuller G; Ziegler-Heitbrock HW; Institute of Immunology, University of Munich, FRG.
The CD4 molecule, which is known to play an important role in the susceptibility of T lymphocytes to infection by the human immunodeficiency virus (HIV), is also expressed in small amounts on the surface of monocytes. Since monocytes can also be infected by the virus, we investigated peripheral blood monocytes of pati
Hull FM; Free University, Amsterdam, The Netherlands.
This paper attempts to analyse some of the complex problems that face primary health care practice in the developed world today. These are shown to be a degree of depersonalisation, that has come with greater efficiency, and a reduction in the quality of the doctor-patient relationship, which has accompanied increased
Goodman MJ; Goodman LE; University of Hawaii, Honolulu 96822.
This paper raises the question of the ethically proper balance in health care policy between the medical-clinical-high technology model of health service and the grass-roots, community based or traditional models of care. Paradoxical imbalances between the two approaches are traced to political, economic or prestige f
S Afr Med J. 1987 Nov 21;72(10):715-6. Unique Identifier : AIDSLINE MED/88071070
Stulting AA; Hendricks ML; Marais AF; Department of Ophthalmology, University of the Orange Free State,; Bloemfontein.
Ophthalmological findings in AIDS include retinal cotton-wool spots, retinal haemorrhages, cytomegalovirus retinitis, conjunctival manifestations of Kaposi s sarcoma, and cranial nerve palsy. About 75% of patients with AIDS have ophthalmological abnormalities. All patients with AID
Medina JW; de Escobar DM; de Vizcaino MA; Sanchez OG; Ballas SK; Hematologico de Occidente, Banco de Sangre del Estato Zulia,; Maracaibo, Venezuela.
To determine the characteristics of blood donors in western Venezuela , we collected data from 1983 to 1985 on 31,320 volunteer donors at the Blood Bank of the State of Zulia in Maracaibo. Fifty-nine percent of the donors were blood group O, 30 percent were group A, 9 percent wer
Orenstein JM; Preble OT; Kind P; Schulof R; George Washington University Medical Center, Washington, D.C.; 20037.
Two inclusions of the endoplasmic reticulum, tubuloreticular inclusion (TRI) and cylindrical confronting cisternae (CCC), are common to lymphocytes from individuals with AIDS and AIDS-related conditions. Both inclusions can be induced in vitro with alpha-interferon (IFN). IFN may also be elevated in both populations.
Froschl M; Ring J; Braun-Falco O; Dermatologische Klinik und Poliklinik,; Ludwig-Maximillians-Universitat Munchen.
Sexually transmitted diseases (STD) are no longer limited to the classic venereal diseases. A great number of viral and bacterial infections can be transmitted by sexual intercourse. Changes in social structures and advances in medicine in recent decades have resulted in greater liberality among the heterosexual and h
Hausser D; Lehmann P; Dubois F; Gutzwiller F; Institut universitaire de medecine sociale et preventive,; Lausanne.
The evaluation of the Stop-Aids campaign is based upon a model of behaviour modification (McAlister) which includes the communication theory of McGuire and the social learning theory of Bandura. Using this model, it is possible to define key variables that are used to measure the impact of the campaign. Process evalua
Michaud PA; Resplendino J; Palasthy E; Chapuisod B; Organisme medico-social vaudois et Service de la sante; publique, Lausanne.
An exhibition on STDs and AIDS, animated constantly by specially trained professionals, was organized in a school for apprentices (6500 pupils). Its purposes: to help youngsters make more personal and responsible decisions about their sexual lives; to reinforce their knowledges on STDs and AIDS transmission and preven
The histological and ultrastructural findings of subacute spongiform encephalopathy (SSE) are described in the cerebral cortex and basal ganglia of a homosexual patient who died with acquired immune deficiency syndrome (AIDS). It is suggested that SSE, beside the diffuse AIDS leukoencephalopathy, might be another morp
Am Fam Physician. 1987 Dec;36(6):101-6. Unique Identifier : AIDSLINE MED/88073852
Clifford DB; Washington University School of Medicine, St. Louis, Missouri.
AIDS dementia complex is a major source of disability for many AIDS patients. Less commonly, the spinal cord or peripheral nerves are affected by HIV infection. Physicians working with AIDS patients must differentiate these manifestations from those caused by the infectious, neopla
Am J Hematol. 1987 Dec;26(4):299-304. Unique Identifier : AIDSLINE MED/88074286
Bel-Ali Z; Dufour V; Najean Y; Department of Nuclear Medicine, Hospital Saint-Louis, Paris,; France.
A platelet kinetic study was performed in 34 patients (33 homosexuals and/or drug addicts) with (in most of them) severe and isolated thrombocytopenia and human immunodeficiency virus positive serological tests. The reported data indicate that the thrombocytopenia is due to an extracorpuscular hyperdestruction. The se
Denton R; Louisiana State University Medical Center, New Orleans.
Acquired immune deficiency syndrome (AIDS) is currently considered the nation s number one health problem. More than 30,000 persons have been diagnosed with this disease to date, and 40,000 new cases are anticipated for the next 2 years. This paper reviews the current facts regarding AIDS, including its modes of trans
Ann Intern Med. 1987 Dec;107(6):828-36. Unique Identifier : AIDSLINE MED/88075531
Grant I; Atkinson JH; Hesselink JR; Kennedy CJ; Richman DD; Spector SA; McCutchan JA; Department of Psychiatry, University of California at San Diego.
Although a high prevalence of central nervous system disease is seen in persons with the acquired immunodeficiency syndrome (AIDS), the natural history of brain involvement with human immunodeficiency virus (HIV) remains poorly understood. Neuropsychologic evaluations of 55 ambulatory homosexual men revealed abnormali
Ann Intern Med. 1987 Dec;107(6):849-51. Unique Identifier : AIDSLINE MED/88075535
Calabrese LH; Proffitt MR; Levin KH; Yen-Lieberman B; Starkey C; Department of Rheumatic and Immunologic Disease, Cleveland Clinic; Foundation, Ohio.
Clinical descriptions of acute or primary infection with the human immunodeficiency virus (HIV) are rare. Among cases previously reported, most describe an acute illness resembling infectious mononucleosis. We describe the case of a 32-year-old homosexual man with an acute illness associated with strong serologic evid
Duvic M; Johnson TM; Rapini RP; Freese T; Brewton G; Rios A; Department of Dermatology, University of Texas Health Sciences; Center, Houston.
Human immunodeficiency virus (HIV) causes a spectrum of immunodysfunction, the most severe of which is the acquired immunodeficiency syndrome (AIDS). We have followed the course of psoriasis in 13 patients over 2 1/2 years in a population of more than 1000 HIV-positive individuals. Four patients had a history of mild
Blumberg RS; Paradis T; Hartshorn KL; Vogt M; Ho DD; Hirsch MS; Leban J; Sato VL; Schooley RT; Infectious Disease Unit, Massachusetts General Hospital, Harvard; Medical School, Boston 02114.
Human immunodeficiency virus (HIV) elicits the production of virus-specific antibodies in infected individuals. We investigated the ability of serum from HIV-infected individuals to mediate antibody-dependent cellular cytotoxicity in an in vitro 51Cr release assay system. Fresh peripheral blood mononuclear cells from
J Med Virol. 1987 Sep;23(1):67-73. Unique Identifier : AIDSLINE MED/88061237
Albert J; Gaines H; Sonnerborg A; Nystrom G; Pehrson PO; Chiodi F; von Sydow M; Moberg L; Lidman K; Christensson B; et al; Department of Virology, National Bacteriological Laboratory,; Stockholm, Sweden.
Human immunodeficiency virus (HIV) has been isolated from plasma in 6 of 7 patients showing clinical symptoms of a primary HIV infection. Parallel cultures from peripheral blood mononuclear cells (PBMC) yielded virus in 5 patients. In one case, virus could only be isolated from the cerebrospinal fluid but not from per
Schiff RG; Kabat L; Kamani N; Department of Radiology, Schneider Children's Hospital, New Hyde; Park, New York.
Lymphoid interstitial pneumonitis (LIP) is a frequent pulmonary complication in the child with the acquired immune deficiency syndrome (AIDS) and human immunodeficiency virus (HIV) infection. We report the gallium scan findings in two children with AIDS and LIP. Gallium scintigraphy in both children demonstrated incre
N Engl J Med. 1987 Dec 24;317(26):1643-7. Unique Identifier : AIDSLINE MED/88065783
Pomerantz RJ; Kuritzkes DR; de la Monte SM; Rota TR; Baker AS; Albert D; Bor DH; Feldman EL; Schooley RT; Hirsch MS; Department of Medicine, Massachusetts General Hospital, Boston; 02114.
Proc Natl Acad Sci U S A. 1987 Dec;84(23):8583-7. Unique Identifier : AIDSLINE MED/88068633
Arthur LO; Pyle SW; Nara PL; Bess JW Jr; Gonda MA; Kelliher JC; Gilden RV; Robey WG; Bolognesi DP; Gallo RC; et al; Program Resources, Inc., National Cancer Institute-Frederick; Cancer Research Facility, MD 21701.
The major envelope glycoprotein of a human immunodeficiency virus (HIV) has been purified and was utilized as a prototype vaccine in chimpanzees. The 120,000-dalton glycoprotein (gp120) was purified from membranes of human T-lymphotropic virus (HTLV)-IIIB-infected cells and the final preparation contained low levels t
J Med Virol. 1987 Sep;23(1):1-9. Unique Identifier : AIDSLINE MED/88061231
Chiodi F; von Gegerfeldt A; Albert J; Fenyo EM; Gaines H; von Sydow M; Biberfeld G; Parks E; Norrby E; Department of Virology, Karolinska Institute School of Medicine,; Stockholm, Sweden.
Two partially overlapping 19 and 22 amino acids long peptides representing a highly immunogenic site of the transmembranous glycoprotein (gp41) of human immunodeficiency virus (HIV) were used as antigen in ELISA tests. The results of antibody determination with this assay were compared with those of three or more conv
Stevenson M; Zhang XH; Volsky DJ; Department of Pathology and Microbiology, University of Nebraska; Medical Center, Omaha 68105.
Noncytopathic infection of human T-lymphoid cell line CR-10 with human immunodeficiency virus (HIV) (CEM-N1T isolate) resulted in a gradual loss of cell surface receptors for OKT4/OKT4A (HIV receptor), OKT8, OKT3, and OKT11 but not for OKT9 (transferrin receptor) within 10 days after infection. Surface receptor declin
Eichberg JW; Zarling JM; Alter HJ; Levy JA; Berman PW; Gregory T; Lasky LA; McClure J; Cobb KE; Moran PA; et al; Southwest Foundation for Biomedical Research, San Antonio, Texas; 78284.
Peripheral blood lymphocytes from chimpanzees infected for 3 months to more than 3 years with human immunodeficiency virus (HIV) had normal T-cell proliferative responses after stimulation with a variety of recall antigens and mitogens, indicating that HIV infection does not cause detectable immunological impairment i
Mayo Clin Proc. 1987 Dec;62(12):1108-15. Unique Identifier : AIDSLINE MED/88064472
Hermans PE; Cockerill FR 3d; Division of Infectious Diseases and Internal Medicine, Mayo; Clinic, Jacksonville, Florida.
Amantadine is well established as the preferred antiviral agent for the prophylaxis of influenza A and may also be beneficial therapeutically when used early in the course of the disease. Idoxuridine is applicable only in the treatment of herpetic keratitis. Currently, acyclovir
Kaufman JD; Valandra G; Roderiquez G; Bushar G; Giri C; Norcross MA; Division of Virology, Food and Drug Administration, Bethesda,; Maryland 20892.
T-cell activation pathways are involved in the regulation of human immunodeficiency virus (HIV) expression. Phorbol 12-myristate 13-acetate (PMA) is a potent inducer of T-cell immune functions and has recently been demonstrated to increase viral replication in cell lines infected with HIV. To define sequences required
N Engl J Med. 1987 Nov 19;317(21):1297-302. Unique Identifier : AIDSLINE MED/88065693
Rothenberg R; Woelfel M; Stoneburner R; Milberg J; Parker R; Truman B; New York City Department of Health.
In a cohort of 5833 subjects in whom the acquired immunodeficiency syndrome (AIDS) was diagnosed in New York City before 1986, the cumulative probability of survival (mean +/- SE) was 48.8 +/- 0.7 percent at one year and 15.2 +/- 1.8 percent at five years. The group with the most favorable survival rate--white homosex
Galanski M; Nischelsky J; Abteilung Diagnostische Radiologie I, Medizinischen Hochschule; Hannover.
In former times Pneumocystis carinii (PC) primarily affected premature infants. More recently, it has proved to be one of the major infectious complications among immunocompromised patients, particularly those with AIDS. The most frequent radiographic feature is diffuse, bilateral alveolar and interstitial perihilar s
Radiol Med (Torino). 1987 Nov;74(5):376-83. Unique Identifier : AIDSLINE MED/88069421
Monti C; Sabbatani S; Servizio di Radiologia, Ospedale Maggiore C. A. Pizzardi,; Bologna.
After revising literature concerning Pneumocystis Carinii Pneumoniae (PCP), the authors undertook a close examination of the immunological system of the HIVab-positive patients that suffered opportunistic pneumopathy from PCP. Hundred-forty-three cases of HIVab-positive (mean age of 29), prevalently heroin drug-users,
Science. 1987 Dec 18;238(4834):1704-7. Unique Identifier : AIDSLINE MED/88070645
Smith DH; Byrn RA; Marsters SA; Gregory T; Groopman JE; Capon DJ; Department of Molecular Biology, Genentech, Inc., South San; Francisco, CA 94080.
The initial event in the infection of human T lymphocytes, macrophages, and other cells by human immunodeficiency virus (HIV-1) is the attachment of the HIV-1 envelope glycoprotein gp120 to its cellular receptor, CD4. As a step toward designing antagonists of this binding event, soluble, secreted forms of CD4 were pro
Sunderam G; Mangura BT; Lombardo JM; Reichman LB; Department of Medicine, University of Medicine & Dentistry of New; Jersey, New Jersey Medical School, Newark.
Howard J; Sattler F; Mahon R; Sperling J; Leedom J; Edmund D. Edelman Health Center, Los Angeles, CA.
We evaluated 100 human immunodeficiency virus (HIV) antibody-positive persons from the only alternate test site in Los Angeles. Thirty-five subjects complained of systemic symptoms suggestive of HIV infection and 65 were completely asymptomatic. Irrespective of symptoms, the group as a whole demonstrated clinical and
Biochem Biophys Res Commun. 1987 Nov 13;148(3):941-6. Unique Identifier : AIDSLINE MED/88077056
Borrebaeck CA; Danielsson L; Moller SA; Department of Biotechnology, University of Lund, Sweden.
Primary in vitro immunization of peripheral blood lymphocytes has been studied for the production of human monoclonal antibodies. Depletion of a lysosome-rich cell population, containing large granular lymphocytes, monocytes, and a subset of T suppressor cells, was shown to be crucial before the cells could be immuniz
Radiology has an important role to play in the management of patients with AIDS. This article will illustrate the radiological aspects that are seen commonly in AIDS rather than cataloguing every conceivable X-ray abnormality that may be found. The aim has been to indicate those findings which are useful pointers in d
Greenspan D; Greenspan JS; Department of Stomatology, School of Dentistry, University of; California, San Francisco.
Oral lesions of opportunistic infections and neoplasms are associated with immunosuppression caused by the human immunodeficiency virus (HIV). These include oral candidiasis, viral lesions such as warts, herpes simplex, herpes zoster and hairy leukoplakia, as well as Kaposi s sarcoma and an aggressive form of periodon
Purdy BD; Plaisance KI; School of Pharmacy, University of Maryland, Baltimore 21201.
An overview of the immune system is presented, and the pathogenesis, transmission, diagnostic tests, diagnosis, immunotherapy, and vaccine development for human immunodeficiency virus (HIV) are reviewed. More than 42,000 cases of acquired immunodeficiency syndrome (AIDS) have now been reported in the
Ciba Found Symp. 1987;129:223-33. Unique Identifier : AIDSLINE MED/88054331
Revel M; Schattner A; Department of Virology, Weizmann Institute of Science, Rehovot,; Israel.
The presence of circulating interferons in the blood of patients with autoimmune diseases and the acquired immune deficiency syndrome (AIDS) raises the question of their possible pathogenetic or defence functions. Interferons control levels of HLA class I and II antigens on cells and can activate or inhibit immune kil
Gen Hosp Psychiatry. 1987 Sep;9(5):331-40. Unique Identifier : AIDSLINE MED/88056241
Kelly K; Department of Psychiatry, Cornell University Medical College, New; York.
AIDS has generated a host of ethical questions that are urgent, poignant, and sometimes unprecedented. These questions fall into several familiar categories of ethical problems, including civil liberties vs. public health, distribution of scarce resources, truth telling, confidentiality, and discrimination, among othe
Caruso A; Terlenghi L; Ceccarelli R; Verardi R; Foresti I; Scura G; Manca N; Bonfanti C; Turano A; Institute of Microbiology, University of Brescia, Italy.
Productive infection of permissive cell cultures by HIV has been detected by different assays of which the measurement of reverse transcriptase (RT) activity has been considered highly specific and sensitive. Here we describe the production and characterization of a mouse hybridoma cell line, MB12, secreting monoclona
An enzyme immunoassay (EIA) was developed for detection of human immunodeficiency virus antigen (HIV Ag) in tissue culture supernatants. The assay was found to be specific for HIV and cheaper, easier to perform and more sensitive than the generally used reverse transcriptase (RT) assay. Cultures of peripheral blood le
Ljunggren K; Fenyo EM; Biberfeld G; Jondal M; Department of Immunology, Karolinska Institute, Stockholm,; Sweden.
A method to detect antibodies which mediate antibody-dependent cellular cytotoxicity (ADCC) against HIV-infected target cells was developed. Normal lymphocytes were used as effector cells and different HIV-infected cell lines as target cells. The level of ADCC varied depending on both the effector cell function and th
Cory JM; Ohlsson-Wilhelm BM; Brock EJ; Sheaffer NA; Steck ME; Eyster ME; Rapp F; Department of Microbiology, Pennsylvania State University College; of Medicine, Hershey 17033.
Flow cytometric detection of human immunodeficiency virus (HIV)-infected lymphoid cells at low frequencies is described. Infected cells from human T lymphoid cell lines H9 and A3.01 were detected at frequencies as low as 10(-4) following indirect immunofluorescence labeling. For labeling, cells were treated with an HI
Andersson J; Ehrnst A; Larsson PH; Hedlund KO; Norrby E; Nybom R; Forsgren M; Olding-Stenquist E; Persson B; Department of Immunology, Stockholm University, Sweden.
Measles virus particles were visualized in the CSF of two patients with verified subacute sclerosing panencephalitis (SSPE) by using scanning electron microscopy. Immunologic identification of the accumulated particles was performed with monoclonal antibodies, directly conjugated to carboxylated microspheres, specific
Smith MS; Brian EL; Pagano JS; Lineberger Cancer Research Center, University of North Carolina,; Chapel Hill 27514.
The new antiviral agent, azidothymidine ( AZT ; BW A509U), is currently the only successful drug in use for patients with acquired immunodeficiency syndrome. The effect of this thymidine analog, 3 -azido-3 -deoxythymidine, on the replication of the lymp
Two chimpanzees, one (C-499) infected with the acquired immunodeficiency syndrome-associated retrovirus type 2 (ARV-2) strain of human immunodeficiency virus (HIV) and one (C-560) infected with the lymphadenopathy-associated virus type 1 (LAV-1) strain of HIV, were inoculated with approximately 10(4) tissue culture in
Medicine (Baltimore). 1987 Nov;66(6):407-37. Unique Identifier : AIDSLINE MED/88065036
McArthur JC; Department of Neurology, Johns Hopkins University School of; Medicine, Baltimore, Maryland.
An understanding of the biologic characteristics and cellular tropism of human immunodeficiency virus (HIV) is critical to appreciate the diverse neurologic manifestations of HIV infection in patients with the acquired immunodeficiency syndrome (AIDS). Only carefully designed prospective studies can provide informatio
Med J Aust. 1987 Nov 16;147(10):510-2. Unique Identifier : AIDSLINE MED/88065214
Atkinson K; Dodds AJ; Concannon AJ; Biggs JC; Department of Haematology, St Vincent's Hospital, Darlinghurst,; NSW.
Since bone-marrow transplant recipients receive considerable quantities of packed-cell, platelet and sometimes leukocyte transfusions, as well as the donor marrow infusion, it would be predictable that acquired immunodeficiency syndrome (AIDS) by blood-product transfusion would occur in this patient population. We rep
Postgrad Med J. 1987;63 Suppl 2:143-6. Unique Identifier : AIDSLINE MED/88068210
Laukamm-Josten U; von Laer G; Feldmeier H; Bienzle U; Uy A; Thomssen R; Guggenmoos-Holzmann I; Landesinstitut fur Tropenmedizin, Berlin, FRG.
Three groups of subjects (58 females, 54 heterosexual males, and 50 homosexual males) received three doses of a recombinant DNA yeast-derived hepatitis B vaccine according to a 0, 1, and 6 month vaccination schedule. Local and general side effects were mild. Seroconversion rates after three injections were not signifi
Postgrad Med J. 1987;63 Suppl 2:147-9. Unique Identifier : AIDSLINE MED/88068211
Prinsen H; Goilav C; Safary A; Andre FE; Piot P; Department of Microbiology, Institute of Tropical Medicine,; Antwerp, Belgium.
A yeast-derived recombinant DNA vaccine against hepatitis B was administered to 314 active homosexual men lacking serum markers for hepatitis B virus. Volunteers were vaccinated intramuscularly in the deltoid region at 0, 1, and 6 months with either a 20- or 40-micrograms dose per injection. Serologic tests for syphil
Johnson PC; Sarosi GA; Septimus EJ; Satterwhite TK; Department of Internal Medicine, University of Texas Health; Science Center, Houston 77030.
Progressive disseminated histoplasmosis is an increasingly common cause of infection in patients with acquired immune deficiency syndrome (AIDS) from areas endemic for histoplasmosis. We report 12 cases of progressive disseminated histoplasmosis associated with AIDS and review 20 previously reported cases. The clinica
Gangadharam PR; Department of Medicine, National Jewish Center for Immunology and; Respiratory Medicine, Denver, CO 80206.
Murine models have proven very useful in studying the pathobiology and chemotherapy of a number of mycobacterioses. While there are a number of significant variations from the human model, a substantial body of experience aids in extrapolating from the murine model to the human condition. The most extensively studied
Sperber SJ; Schleupner CJ; Infectious Diseases Section, Veterans Administration Medical; Center, Salem, Virginia 24153.
Salmonella bacteremia is being identified with increasing frequency in persons infected with the human immunodeficiency virus. Salmonellosis may occur in patients with an established diagnosis of acquired immunodeficiency syndrome (AIDS), or it may be the first manifestation of this disorder. In patients with AIDS, sa
Padian NS; School of Public Health, University of California, Berkeley; 94720.
The heterosexual transmission of the acquired immunodeficiency syndrome (AIDS) has been documented in the United States by national surveillance data and heterosexual partner studies since the beginning of the epidemic. However, the efficiency of heterosexual transmission and related r
Nelkin D; Program on Science, Technology and Society, Cornell University,; Ithaca, New York 14853.
This paper reviews several areas of social science research that are relevant to the critical social dimensions of the AIDS crisis. These dimensions include how to effect changes in behavior so as to break the chain of transmission, how best to inform the public about risks so as to develop reasonable and nondiscrimin
Check WA; Medical and Scientific Communications, Atlanta, Georgia 30340.
Mass media have functioned well in transmitting much of the basic information about the AIDS epidemic; however, media coverage of AIDS has been flawed. In many ways these flaws have resulted from the limitations and conventions of traditional journalism, especially the need to appeal to a large mainstream audience and
Merger C; Blanc B; Ruf H; Hopital de Magenta, CHT de Noumea.
The population of women, HIV positive, and susceptible to become pregnant, increases with time. Pregnancy must be contra-indicated in seropositive women. A termination of pregnancy must be performed in the first trimester and a therapeutic abortion may be offered but left to the mother s decision. Delivery must be car
AIDS as a new lethal and at present incurable sexually transmitted disease is already having remarkable social repercussions not yet fully explicit and hence it can be termed a social phenomenon. Political, behavioural, economic and legal reactions and social responses such as stigmatization, changes in the sick role
Velimirovic B; Institute of Social Medicine, University of Graz, Austria.
AIDS is an infectious but also a social disease. Next to the major epidemiological question on the natural history of AIDS, important problems have been posed in various fields of social, political, ethical and legal areas extending far beyond traditional medical interest. These create polarization among public, polit
Cloyd MW; Holt MJ; Department of Surgery, Duke University Medical Center, Durham,; North Carolina 27710.
We examined the antigens of human immunodeficiency viruses (HIV) expressed on infected H9 cells using live-cell membrane immunofluorescence and immunofluorescence absorption. Application of this nondenaturing serological method permitted analysis of HIV antigenic determinants maintained in their native configurations
The authors have investigated the antibody binding with individual HIV protein by western blotting method. The optimal condition for binding was incubation of nitrocellulose strips at 37 degrees C for 2 hrs followed by incubation at 4 degrees C overnight. Differences in the serologic activities of a number of sera in
Nunez RM; Raad J; Nunez CA; Departamento de Pediatria, Hospital Infantil, Universidad de; Caldas, Manizales, Colombia.
The presence of antibodies against spermatozoids was evaluated in one person with AIDS and six homosexuals (HS). Indirect immunofluorescence was utilized along with immunoenzymatic trial with peroxidase (ELISA) in order to detect antibodies class IgG towards spermatozoids and their membrane proteins. Optic densities o
Busch MP; Rajagopalan MS; Gantz DM; Fu S; Steimer KS; Vyas GN; Department of Laboratory Medicine, University of California, San; Francisco 94143-0100.
The authors characterized the early intracellular events involved in human immunodeficiency virus (HIV) replication after in vitro inoculation into cultures of susceptible human T-cell lines and phytohemagglutinin-stimulated peripheral-blood mononuclear cells (PMCs). Within 24 hours of infection, in situ hybridization
JAMA. 1988 Jan 1;259(1):55-8. Unique Identifier : AIDSLINE MED/88063175
Peterman TA; Stoneburner RL; Allen JR; Jaffe HW; Curran JW; AIDS Program, Centers for Disease Control, Atlanta, GA 30333.
The risk of human immunodeficiency virus (HIV) transmission was studied by interviewing and testing the serum of heterosexual contacts and casual family contacts of adults with transfusion-associated HIV infections. Two (8%) of 25 husbands and ten (18%) of 55 wives who had had sexual contact with infected spouses were
Willey RL; Smith DH; Lasky LA; Theodore TS; Earl PL; Moss B; Capon DJ; Martin MA; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland 20892.
Site-specific mutagenesis was used to introduce amino acid substitutions at the asparagine codons of four conserved potential N-linked glycosylation sites within the gp120 envelope protein of human immunodeficiency virus (HIV). One of these alterations resulted in the production of noninfectious virus particles. The a
Wu F; Garcia J; Mitsuyasu R; Gaynor R; Department of Medicine, University of California-Los Angeles; School of Medicine.
Five regions of the human immunodeficiency virus (HIV) long terminal repeat (LTR) serve as binding sites for cellular proteins as demonstrated by DNase I footprinting. These include the negative regulatory, enhancer, SP1, TATA, and untranslated regions. The HIV enhancer region contains two direct repeats of a sequence
Romano AJ; vanSonnenberg E; Casola G; Gosink BB; Withers CE; McCutchan JA; Leopold GR; Department of Radiology, University of California Medical Center,; San Diego 92103.
Gallbladder and biliary tract abnormalities were observed on sonography in eight patients with AIDS. The studies were obtained to evaluate right upper quadrant pain (two patients), tenderness (three patients), and abnormal liver function tests (eight patients). The two major sonographic findings were gallbladder wall
Kernoff PB; Miller EJ; Savidge GF; Machin SJ; Dewar MS; Preston FE; Department of Haematology, Royal Free Hospital, London.
The risk of post-infusion non-A, non-B hepatitis (NANBH) in patients receiving a first exposure to unheated or conventionally dry heated factor VIII concentrates approaches 100%, implying invariable contamination of these products. Amongst 18 patients who received a first treatment with a wet heated commercial con
Kloster BE; John PA; Miller LE; Rubin LA; Nelson DL; Blair DC; Tomar RH; Department of Pathology, SUNY Health Science Center at Syracuse; 13210.
Utilizing an enzyme-linked immunosorbent assay, we detected elevated serum levels of soluble interleukin 2 receptors (SIL-2R) in 73% of patients with acquired immunodeficiency syndrome (AIDS), 80% of AIDS-related complex patients, 78% of anti-HIV-positive lymphadenopathy syndrome patients, 85% of HIV-antibody-positive
Nydegger UE; Vaudaux P; Castelli D; Central Laboratory of Hematology, University Hospital of Bern.
After a rather long initial period fraught with difficulties, plasma exchange has become an adjunct to the treatment of numerous diseases, such as hyperviscosity syndrome, where it alleviates disease symptoms, hemophilia due to inhibitors to clotting factor VIII, thrombotic thrombocytopenic purpura, rapidly progressin
JAMA. 1988 Jan 1;259(1):65-8. Unique Identifier : AIDSLINE MED/88063177
Ewing NP; Sanders NL; Dietrich SL; Kasper CK; Department of Medicine, University of Southern California School; of Medicine, Los Angeles.
Induction of immune tolerance in patients with severe hemophilia A and inhibitors to factor VIII was attempted by daily infusion of 50 U of factor VIII per kilogram of body weight without adjunctive immunosuppressive drugs. Modest initial anamnestic elevation of inhibitor levels occurred in six patients within the fir
Nature. 1987 Dec 3-9;330(6147):487-9. Unique Identifier : AIDSLINE MED/88065878
McClure MO; Sattentau QJ; Beverley PC; Hearn JP; Fitzgerald AK; Zuckerman AJ; Weiss RA; Chester Beatty Laboratories, Institute of Cancer Research,; London, UK.
The CD4 T-lymphocyte differentiation antigen is an essential component of the cell surface receptor for human immunodeficiency viruses (HIVs) causing AIDS (acquired immune deficiency syndrome) (refs 1-3). Peripheral blood lymphocytes of apes, New World and Old World monkeys express cell surface antigens homologous to
Real R; Thomas M; Gerwin JM; Department of Surgery, University of Alabama Center, Birmingham.
We have presented a case of a male homosexual with documented acquired immune deficiency syndrome in whom sudden sensorineural hearing loss developed after a series of opportunistic infections and before a massive intracerebral hemorrhage. Two major possible causes of his hearing loss are (1) actual involvement of spi
Public Health Rep. 1987 Nov-Dec;102(6):677-81. Unique Identifier : AIDSLINE MED/88069066
Hopkins DR; Centers for Disease Control, Atlanta, GA 30333.
Among ethnic minorities in the United States , blacks and Hispanics, who compose 12 percent and 7 percent of the U.S. population, respectively, constitute 24 percent and 14 percent of the cases of AIDS. Seventy-eight percent of all children with AIDS are black or Hispanic, as are 71 per
Public Health Rep. 1987 Nov-Dec;102(6):692-7. Unique Identifier : AIDSLINE MED/88069069
Saltzman SP; Stoddard AM; McCusker J; Moon MW; Mayer KH; Fenway Community Health Center, Boston, MA.
This study was undertaken to determine the reliability of self-reported sexual behavior using the test and retest technique when used with self-reported sexual behavior. The subjects were 116 asymptomatic homosexual men who participated in another study (an examination of behavioral and demographic determinants of HIV
Daenen S; Hoogeveen Y; Smit JW; van Imhoff GW; van der Meer J; de Wolf JT; Sibinga CT; Halie RM; Department of Internal Medicine, University of Groningen, The; Netherlands.
At the change from unheated to heat-treated Factor VIII concentrates for the treatment of hemophilia A, 17 severe adult hemophiliacs (mean monthly dose, 4927 IU) were evaluated prospectively for signs of infection with human immunodeficiency virus (HIV). Viral serology and lymphocyte subpopulations (OKT3, OKT4, and OK
Am J Dermatopathol. 1987 Oct;9(5):388-98. Unique Identifier : AIDSLINE MED/88075018
Ruszczak Z; Mayer-Da Silva A; Orfanos CE; Department of Dermatology, University Medical Center Steglitz,; Free University of Berlin, F.R. Germany.
Light-microscopic, immunohistochemical, and ultrastructural studies were performed on biopsy material from 15 young homosexual men with AIDS-associated mucocutaneous Kaposi s sarcoma; 19 Kaposi s sarcoma lesions in different developmental stages were investigated. These lesions showed multicentrically arising and prol
Biochem Pharmacol. 1987 Nov 15;36(22):3797-800. Unique Identifier : AIDSLINE MED/88077113
Ahluwalia G; Cooney DA; Mitsuya H; Fridland A; Flora KP; Hao Z; Dalal M; Broder S; Johns DG; Division of Cancer Treatment, National Cancer Institute,; Bethesda, MD 20892.
Kozeny GA; Quinn JP; Bansal VK; Vertuno LL; Hano E; Section of Nephrology, Loyola University Medical Center, Maywood,; Illinois.
A previously healthy, HIV-negative, 67-year-old man developed rapidly progressive glomerulonephritis. Following pulse methylprednisolone therapy he developed Pneumocystis carinii pneumonia. This complication should be recognized as a potential hazard of pulse steroid therapy.
Laurence J; Kulkosky J; Friedman SM; Posnett DN; Ts'o PO; Laboratory for Acquired Immunodeficiency Syndrome (AIDS); Research, Hospital for Special Surgery, New York, New York.
Two alloreactive human CD4+ T cell clones, recognizing HLA-DR2 and HLA-DR1 determinants, lost their specific proliferative capacity after infection with HIV. This system was used to explore the effect of polyI.polyC12U on HIV replication and immune suppression. The mismatched double-stranded RNA blocked HIV-associated
Flomenberg PR; Chen M; Horwitz MS; Department of Medicine, Albert Einstein College of Medicine,; Bronx, New York 10461.
Adenovirus type 35 (Ad35) is a group B adenovirus that has been isolated primarily from patients with acquired immunodeficiency syndrome and other immunodeficiency disorders. We have studied the interaction of this unique adenovirus with the immune system by analyzing Ad35 early viral proteins in infected HeLa cells.
Am J Drug Alcohol Abuse. 1987;13(4):401-12. Unique Identifier : AIDSLINE MED/88074207
Shine D; Moll B; Emeson E; Spigland I; Harris C; Small CB; Friedland G; Weiss SH; Bodner AJ; Department of Medicine, Montefiore Medical Center, Bronx, New; York.
We screened inpatient and outpatient parenteral drug users with no clinical evidence of AIDS for immunodeficiency and antibodies to HTLV-III by ELISA. Among 20 outpatient drug users, 5 (25%) were seropositive. Three of these (and 2 who were seronegative) had low T-cell ratios. Over 6 months, 1 seropositive patient wit
The method of transfection of eukaryotic cells by plasmid DNA and production of recombinant vaccinia virus is described. The method is based on DNA encapsulation into reverse evaporation vesicles containing gangliosides, with a subsequent incubation of liposomes with vaccinia-infected cells in the presence of UV-inact
Rechavi G; Ben-Bassat I; Berkowicz M; Martinowitz U; Brok-Simoni F; Neumann Y; Vansover A; Gotlieb-Stematsky T; Ramot B; Institute of Hematology, Chaim Sheba Medical Center,; Tel-Hashomer, Israel.
In two hemophilic brothers infected by the human immunodeficiency virus (HIV), Burkitt s leukemia developed within 1 year. Both patients were treated by aggressive chemotherapy, and both are still in complete remission for 23 and 14 months, respectively. Sera from both brothers contained anti-HIV antibodies. However,
Hoover EA; Mullins JI; Quackenbush SL; Gasper PW; Department of Pathology, Colorado State University, Fort Collins; 80523.
We describe the identification, experimental transmission, and pathogenesis of a naturally occurring powerfully immunosuppressive isolate of feline leukemia virus (designated here as FeLV-FAIDS) which induces fatal acquired immunodeficiency syndrome (AIDS) in 100% (25 of 25) of persistently viremic experimentally infe
Cancer. 1987 Dec 15;60(12):2941-7. Unique Identifier : AIDSLINE MED/88052494
Garcia CR; Brown NA; Schreck R; Stiehm ER; Hudnall SD; Department of Medicine, UCLA School of Medicine.
Patients with congenital and acquired immunodeficiencies are at increased risk for the development of B-cell lymphoproliferative disorders. When the appropriate tests have been performed, the Epstein-Barr virus (EBV) nuclear antigen (EBNA) or EBV DNA has been found in tissues from these tumors. These data have provide
Cancer Surv. 1985;4(4):633-53. Unique Identifier : AIDSLINE MED/88052683
Deuel TF; Kimura A; Maehama S; Tong BD; Jewish Hospital at Washington University Medical Center, St.; Louis, Missouri 63110.
Platelet-derived growth factor (PDGF) is the most potent mitogenic protein in human serum. The normal roles of this protein may relate to its potent mitogenic properties and its activities in directed cell migration and at sites of wounds. PDGF is a heterodimeric protein of approximately 30,000 molecular weight; one p
Shalaby MR; Krowka JF; Gregory TJ; Hirabayashi SE; McCabe SM; Kaufman DS; Stites DP; Ammann AJ; Department of Pharmacological Sciences, Genetech, Inc., South San; Francisco, California 94080.
The effect of human immunodeficiency virus (HIV) recombinant envelope glycoprotein 120 (rgp 120) on the functions of peripheral blood mononuclear cells (PBMC) in vitro was investigated. The results demonstrate that rgp 120 used at concentrations less than 1 microgram/ml has no significant effects on PBMC function in v
Baldwin S; Stagno S; Whitley R; Department of Pediatrics and Microbiology, University of Alabama,; Birmingham School of Medicine.
Viral infections are a frequent occurrence following transfusion of blood products. While generally benign, these infections are capable of causing significant morbidity and mortality. Therefore, it is prudent to follow several general approaches diligently to reduce the risks of these infections in patients undergoin
Sandstrom EG; Kaplan JC; Department of Dermatology, Sodersjukhuset, Karolinska Institute,; Stockholm.
The rapid spread of human immunodeficiency virus (HIV) infections and the grim outcome of these infections have focused interest on the possibilities for medical intervention. The end-stage of these infections, acquired immune deficiency syndrome (AIDS), was first recognised in 1981, and the causative agent isolated i
Ambros RA; Lee EY; Sharer LR; Khan MY; Robboy SJ; Department of Pathology, University of Medicine and Dentistry of; New Jersey-New Jersey Medical School, Newark 07103.
Clinical and necropsy findings in 13 intravenous drug abusers who died of the acquired immunodeficiency syndrome (AIDS) were reviewed and compared with findings in eight patients who acquired the infection through sexual exposure, the most common mode of transmission in AIDS. No differences were found in lymphocyte co
Jama H; Grillner L; Biberfeld G; Osman S; Isse A; Abdirahman M; Bygdeman S; Department of Clinical Bacteriology, Huddinge University; Hospital, Stockholm, Sweden.
The prevalence of serum antibodies to human immunodeficiency virus (HIV), herpes simplex virus (HSV), and cytomegalovirus ( CMV ) and of hepatitis B virus (HBV) markers was investigated in different population groups, including
J Am Vet Med Assoc. 1987 Sep 15;191(6):705-6. Unique Identifier : AIDSLINE MED/88058373
Monticello TM; Levy MG; Bunch SE; Fairley RA; Department of Microbiology, School of Veterinary Medicine, North; Carolina State University, Raleigh.
A 4-year-old FeLV-positive cat with a 1-year history of intermittent diarrhea and subsequent anorexia, depression, and weight loss had enteric cryptosporidiosis at necropsy. Cryptosporidium sp is an important cause of gastroenteritis and diarrhea in various species, including human beings with acquired immunodeficienc
Heldin CH; Westermark B; Ludwig Institute for Cancer Research, Uppsala Branch, Sweden.
PDGF is a dimeric molecule consisting of A chains and B chains. All three dimeric combinations have been found in platelets, or produced by certain normal or transformed cell types; whether functional differences occur between different dimers is currently under investigation. Production of PDGF-like factors by cells
Deuel TF; Pierce GF; Yeh HJ; Shawver LK; Milner PG; Kimura A; Department of Medicine, Jewish Hospital of St. Louis at; Washington University School of Medicine, MO 63110.
Platelet-derived growth factor (PDGF) is the major growth factor in serum and a potent mitogen for cells mesenchymal origin. It is a highly basic heterodimeric protein with a molecular mass of approximately 30 kDa and binds to a cell surface receptor with high affinity. The amino acid sequence of PDGF revealed sequenc
J Immunol. 1987 Dec 1;139(11):3637-43. Unique Identifier : AIDSLINE MED/88060462
Froelich CJ; Guiffaut S; Department of Medicine, University of Illinois College of; Medicine at Chicago 60612.
The human T cell leukemia (HTLV-1) retrovirus is the etiologic agent for adult T cell leukemia. Interleukin 2 ( IL-2 ) activated killer (AK) cells have been shown to lyse freshly explanted tumor cells in vitro and have been used as a form of adoptive immunotherapy for th
Ostrove JM; Leonard J; Weck KE; Rabson AB; Gendelman HE; Laboratory of Clinical Investigation, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland 20892.
Herpes simplex virus type 1 (HSV-1) and some of its immediate-early genes stimulate expression of the human immunodeficiency virus (HIV) long terminal repeat (LTR) sequences and the replication of HIV itself. To demonstrate this, the HIV LTR was linked to the indicator gene chloramphenicol acetyltransferase (CAT) and
Dewhurst S; Sakai K; Bresser J; Stevenson M; Evinger-Hodges MJ; Volsky DJ; Molecular Virology Laboratory, St. Luke's/Roosevelt Hospital; Center, New York, New York.
The nature of the interaction between human immunodeficiency virus (HIV) and human cells of astrocytic origin was studied in vitro with cultured glial cells and intact HIV or infectious molecular clones of the virus. Infection of glial cells with intact HIV was characterized by low-level expression of viral transcript
Lairmore MD; Akita GY; Russell HI; DeMartini JC; Department of Pathology, College of Veterinary Medicine and; Biomedical Sciences, Colorado State University, Fort Collins; 80523.
Ruminant lentiviruses share genomic sequences and biologic properties with human immunodeficiency viruses. Four ovine lentivirus strains were assessed for cytopathic effects and virus replication. Lentivirus isolate H/24 produced high virus titers and lysis of synovial cells but replicated slowly and caused no fusion
Braun MJ; Clements JE; Gonda MA; Laboratory of Cell and Molecular Structure, National Cancer; Institute-Frederick Cancer Research Facility, Maryland 21701.
The complete nucleotide sequence of the visna virus 1514 genome was determined. Our sequence confirms the relationship of visna virus and other lentiviruses to human immunodeficiency virus (HIV) both at the level of sequence homology and of genomic organization. Sequence homology is shown to extend to the transmembran
Mager DL; Freeman JD; Terry Fox Laboratory, British Columbia Cancer Research Centre,; Vancouver, Canada.
We have cloned several prototypic members of the family of human endogenous retroviruslike elements having a histidine tRNA primer-binding site (RTVL-H) and have determined the nucleotide sequence of one of these clones (RTVL-H2). The RTVL-H2 sequence is 5,813 nucleotides long, with long terminal repeats of 450 nucleo
Sherman L; Gazit A; Yaniv A; Kawakami T; Dahlberg JE; Tronick SR; Department of Human Microbiology, Sackler Faculty of Medicine,; Tel-Aviv University, Israel.
We used the Escherichia coli chloramphenicol acetyltransferase gene (cat) to study sequences that influence expression of the equine infectious anemia virus (EIAV) genome. The EIAV long terminal repeat (LTR) directed CAT activity in a canine cell line, but at levels much lower than those achieved with other eucaryotic
Biberfeld P; Kramarsky B; Salahuddin SZ; Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, MD 20892.
A new DNA virus, designated human B lymphotropic virus or human herpesvirus 6 (HBLV), has been isolated from the peripheral blood leukocytes of patients with various lymphoproliferative disorders, in some instances also associated with human immunodeficiency virus (HIV-1) infection. HBLV, propagated in vitro in human
Nature. 1987 Nov 26-Dec 2;330(6146):391-5. Unique Identifier : AIDSLINE MED/88065861
Franza BR Jr; Josephs SF; Gilman MZ; Ryan W; Clarkson B; Cold Spring Harbor Laboratory, New York 11724.
Numerous nucleic acid sequence motifs have been identified as transcriptional regulatory elements, and proteins involved in the control of gene replication and transcription have been successfully purified using nucleic acid affinity procedures. We have developed an assay that allows direct characterization of cellula
Nature. 1987 Dec 3-9;330(6147):489-93. Unique Identifier : AIDSLINE MED/88065879
Kao SY; Calman AF; Luciw PA; Peterlin BM; Howard Hughes Medical Institute, Department of Medicine,; University of California, San Francisco 94143.
Human immunodeficiency virus-1 (HIV-1) gene expression is controlled by cellular transcription factors and by virally encoded trans-activation proteins of the HIV-1 tat and art/trs genes, which are essential for viral replication. Tat trans-activates HIV-1 gene expression by interacting with the trans-acting response
Proc Natl Acad Sci U S A. 1987 Nov;84(22):8120-4. Unique Identifier : AIDSLINE MED/88068547
Walker BD; Kowalski M; Goh WC; Kozarsky K; Krieger M; Rosen C; Rohrschneider L; Haseltine WA; Sodroski J; Infectious Disease Unit, Massachusetts General Hospital, Boston.
Castanospermine (1,6,7,8-tetrahydroxyoctahydroindolizine) is a plant alkaloid that modifies glycosylation by inhibiting alpha-glucosidase I. Castanospermine is shown to inhibit syncytium formation induced by the envelope glycoprotein of the human immunodeficiency virus and to inhibit viral replication. The decrease in
Proc Natl Acad Sci U S A. 1987 Dec;84(23):8642-6. Unique Identifier : AIDSLINE MED/88068645
Davis MG; Kenney SC; Kamine J; Pagano JS; Huang ES; Lineberger Cancer Research Center, University of North Carolina,; Chapel Hill 27514.
Almost all homosexual patients with acquired immunodeficiency syndrome are also actively infected with human cytomegalovirus (HCMV). We have hypothesized that an interaction between HCMV and human immunodeficiency virus (HIV), the agent that causes acquired immunodeficiency syndrom
Levine MS; Woldenberg R; Herlinger H; Laufer I; Department of Radiology, Hospital, University of Pennsylvania,; Philadelphia 19104.
Thirty-five of 90 patients with acquired immunodeficiency syndrome (AIDS) seen between 1983 and 1986 underwent esophagography (double contrast in all but two) to rule out opportunistic esophagitis; 20 of the 35 were found to have fungal or viral esophagitis. A radiographic diagnosis of Candida esophagitis was made in
Hughes WT; Department of Child Health Sciences, St Jude Children's Research; Hospital, Memphis, TN 38101.
Certain types and causes of pneumonia are unique to the immunocompromised host. The most frequent causes are cytomegalovirus , Pneumocystis carinii, varicella zoster virus, Candida species and Aspergillus species. Lymphoid interstitial pneumonia has recently been recognized in child
Science. 1987 Dec 11;238(4833):1575-8. Unique Identifier : AIDSLINE MED/88070623
Siekevitz M; Josephs SF; Dukovich M; Peffer N; Wong-Staal F; Greene WC; Howard Hughes Medical Institute, Duke University School of; Medicine, Durham, NC 27710.
To investigate the mechanism by which immune activation augments replication of the human immunodeficiency virus type 1 (HIV-1) in infected T cells, four different classes of T cell mitogens were evaluated for their effects on the HIV-1 long terminal repeat (LTR). Phytohemagglutinin (PHA), a mitogenic lectin; phorbol
Science. 1987 Dec 11;238(4833):1581-3. Unique Identifier : AIDSLINE MED/88070625
Manzari V; Gismondi A; Barillari G; Morrone S; Modesti A; Albonici L; De Marchis L; Fazio V; Gradilone A; Zani M; et al; Dipartimento di Medicina Sperimentale e Scienze Biochimiche II,; Universita di Roma, Tor Vergata, Italy.
A new human retrovirus was isolated from a continuous cell line derived from a patient with CD4+ Tac- cutaneous T cell lymphoma/leukemia. This virus is related to but distinct from human T cell leukemia/lymphoma virus types I and II (HTLV-I and HTLV-II) and human immunodeficiency virus (HIV-1). With the use of a fragm
Fukasawa M; Tsujimoto H; Ishikawa K; Miura T; Ivanoff B; Cooper RW; Frost E; Delaporte E; Mingle JA; Grant FC; et al; Department of Animal Pathology, University of Tokyo, Tokyo.
Two isolates of human T-cell leukemia virus type I (HTLV-I) were obtained from lymphocyte cultures of a healthy carrier in Gabon and another in Ghana . Their proviruses were analyzed by Southern blot hybridization and compared with prototypical HTL
Payne SL; Fang FD; Liu CP; Dhruva BR; Rwambo P; Issel CJ; Montelaro RC; Department of Biochemistry, Louisiana State University, Baton; Rouge 70803.
The extent and nature of genomic variation among nine antigenically distinct EIAV isolates recovered during sequential clinical episodes from two experimentally infected ponies were examined by restriction fragment analysis and nucleotide sequencing. Only minor variations in restriction enzyme patterns were observed a
Sanchez A; Richardson MA; Yoshida M; Furuichi Y; Department of Molecular Genetics, Nippon Roche Research Center,; Kanagawa, Japan.
The pX gene of human T-cell leukemia virus type I (HTLV-I) encodes a protein that activates the expression of viral genes in trans. Plasmid constructs designed to express the pX gene under the control of either the temperature-inducible lambda PL promoter or the trp promoter were used to transform several Escherichia
Hamamoto Y; Harada S; Yamamoto N; Uemura Y; Goto T; Suyama T; Department of Virology and Parasitology, Yamaguchi University,; Japan.
More than 10(4) plaque-forming units (pfu)/ml of HIV are inactivated during the alcohol fractionation step from plasma to fraction (Fr)-II+III, greater than 10(4) pfu/ml is inactivated from Fr-II+III to Fr-II and greater than 10(4) pfu/ml is inactivated during the polyethylene glycol (PEG) fractionation process from F
Z Gastroenterol. 1987 Oct;25(10):673-6. Unique Identifier : AIDSLINE MED/88072624
Sibrowski W; von Wulffen H; Henning H; Laufs R; Institut fur Medizinische Mikrobiologie und Immunologie,; Universitats-Krankenhauses Eppendorf, Hamburg.
Sera from 367 patients presumed to have NANB hepatitis were screened for reverse transcriptase activity. In 29 cases significantly increased enzyme activities could be observed. In contrast, sera from 338 patients did not contain significant reverse transcriptase activities. 207 healthy individuals, 7 patients with he
Am J Gastroenterol. 1987 Dec;82(12):1264-70. Unique Identifier : AIDSLINE MED/88074237
Culpepper-Morgan JA; Kotler DP; Scholes JV; Tierney AR; Department of Medicine, St. Luke's-Roosevelt Hospital Center,; College of Physicians and Surgeons, Columbia University, New; York.
Mucosal cytomegalic inclusion disease (CID) is a serious complication in acquired immune deficiency syndrome (AIDS) that usually is associated with disseminated cytomegalovirus ( CMV ) infection, and leads progressively to deat
Ann Ophthalmol. 1987 Oct;19(10):369-73,375. Unique Identifier : AIDSLINE MED/88075650
Bach MC; Hedstrom PS; Department of Medicine (Infectious Diseases), Maine Medical; Center, Portland.
Three patients with acquired immunodeficiency syndrome (AIDS) and disseminated cytomegalovirus ( CMV ) infection were treated with a new antiviral agent ganciclovir [9(1,3-dihydroxy-2-propoxymethyl) guanine] (DHPG). All initial
Biochem Biophys Res Commun. 1987 Oct 29;148(2):726-33. Unique Identifier : AIDSLINE MED/88076948
Tochikura TS; Nakashima H; Hirose K; Yamamoto N; Dept. of Virology and Parasitology, Yamaguchi University School; of Medicine, Japan.
PSK, a biological response modifier (BRM), was studied to determine its anti-viral activity on human immunodeficiency virus (HIV) in vitro. Either a novel infection system using human T-cell lymphotropic virus type I (HTLV-I)-carrying MT-4 cells or a coculture system using MOLT-4 cells and its virus-producing cells MO
Biochem Biophys Res Commun. 1987 Nov 13;148(3):1252-8. Unique Identifier : AIDSLINE MED/88077009
Johnson MA; Johns DG; Fridland A; Department of Biochemical and Clinical Pharmacology, St. Jude; Children's Research Hospital, Memphis, Tennessee 38105.
As a first step toward improving dideoxynucleoside inhibition of human immunodeficiency virus replication in human lymphocytes, we examined the kinetics of 5 -phosphorylation of a series of 2 ,3 -dideoxynucleosides, using deoxycytidine kinase purified from human thymus extracts. Nucleosides with the 2 -deoxyribose moi
Biochem Biophys Res Commun. 1987 Nov 13;148(3):899-905. Unique Identifier : AIDSLINE MED/88077050
Bohan C; York D; Srinivasan A; Division of Viral Diseases, Centers for Disease Control, Atlanta,; GA 30333.
To study the effect of sodium butyrate on human immunodeficiency virus (HIV) long terminal repeat (LTR)--directed expression, we constructed a chimeric plasmid (pLTR-CAT) in which the LTR sequences derived from a molecular clone of HIV were fused to the chloramphenicol acetyltransferase (CAT) gene. We used transient e
Br Med J (Clin Res Ed). 1987 Oct 10;295(6603):873-5. Unique Identifier : AIDSLINE MED/88051735
Dearden CE; Matutes E; Hoffbrand AV; Ganeshaguru K; Brozovic M; Williams HJ; Traub N; Mills M; Linch DC; Catovsky D; Medical Research Council Leukaemia Unit, Hammersmith Hospital,; London.
The adenosine deaminase inhibitor deoxycoformycin was used in low doses to treat 19 patients with clinically aggressive T cell malignancy with a mature membrane phenotype. The patients comprised eight with prolymphocytic leukaemia, two with chronic lymphocytic leukaemia, four with adult T cell leukaemia-lymphoma, thre
Cancer. 1987 Dec 1;60(11):2605-8. Unique Identifier : AIDSLINE MED/88052443
Lofters W; Campbell M; Gibbs WN; Cheson BD; University of the West Indies, Kingston, Jamaica.
Six Caribbean patients with histologically and immunologically characterized adult T-cell leukemia/lymphoma (ATL) were treated intravenously (IV) with 2 -deoxycoformycin (DCF) at a dose of 5 mg/m2 on days 1, 2, 8, 15, and 22 with four additional weekly doses to convert any partial responses (PR) to complete responses
Yonekura S; Nagao T; Komatsuda M; Arimori S; Fourth Department of Internal Medicine, School of Medicine, Tokai; University, Isehara, Japan.
A female patient who had been initially diagnosed with non-Hodgkin s lymphoma (NHL) and achieved complete clinical remission with combined chemotherapy, developed overt adult T-cell leukemia (ATL) after 9 yr of disease-free survival. This is the first case of the development of ATL
Matsushima M; Yoneyama A; Nakamura T; Higashihara M; Yatomi Y; Tanabe A; Ohashi T; Oka H; Nakahara K; First Department of Internal Medicine, Faculty of Medicine,; University of Tokyo, Japan.
A case of complete remission of adult T-cell leukemia (ATL) induced by beta-interferon is reported. A 46-year-old male was diagnosed as ATL because of the increased number of ATL cells with deeply indented and lobulated nuclei in the peripheral blood, accompanied by elevated values of the lactic dehydrogenase, the alk
Int J Cancer. 1987 Nov 15;40(5):629-34. Unique Identifier : AIDSLINE MED/88057708
Sonoda S; Yashiki S; Takahashi K; Arima N; Daitoku Y; Matsumoto M; Matsumoto T; Tara M; Shinmyozu K; Sato K; et al; Dept. of Virology, Faculty of Medicine, Kagoshima University,; Japan.
The HLA types of peripheral blood lymphocytes (PBL) of 36 adult T-cell leukemia/lymphoma (ATLL) patients were examined and compared with those of 45 healthy relatives of these patients, and with those of 10 non-ATLL families including 80 healthy members. Thirty-one percent of ATLL patients showed either a gain or a lo
Miyamoto K; Kagami Y; Shimoyama M; Miwa M; Tomita N; Suzuki C; Ishii A; Sanada H; Hiraki Y; Kitajima K; et al; School of Health Sciences, Okayama University.
A unique T-cell line, designated ATL-5T, was established from lymphoma cells in pericardial effusion of an adult T-cell leukemia (ATL) patient not carrying HTLV-1 provirus. The cell line is OKT4 and/or Leu3a+ and OKT8 and/or Leu2a+, but interleukin 2 receptor (IL2R)- and HTLV-1 provirus genome negative, and has cytoge
Suzuki Y; Hirabayashi Y; Matsumoto N; Kato H; Hidari K; Tsuchiya K; Matsumoto M; Hoshino H; Tozawa H; Miwa M; Department of Biochemistry, University of Shizuoka, School of; Pharmaceutical Science.
Gangliosides (GM3, GD3, GM2, gangliotetraose-series gangliosides) and their asialo derivatives of several adult T-cell leukemia (ATL) cell lines (ATL-1K, ATL-3I, ATL-5S, and MT-2 cells) and the lymphocytes from a patient with ATL were quantified by highly sensitive enzyme-immunostaining on silica gel thin layer chroma
Knobler RM; Rehle T; Grossman M; Saxinger CW; Berger CL; Oster M; McKiernan GE; Edelson RL; IInd Department of Dermatology, University of Vienna, Austria.
A woman who emigrated to the United States from the Dominican Republic developed the first signs of cutaneous T cell lymphoma during the last trimester of her pregnancy. This patient, found to have a
J Med Virol. 1987 Sep;23(1):51-66. Unique Identifier : AIDSLINE MED/88061236
von Briesen H; Becker WB; Henco K; Helm EB; Gelderblom HR; Brede HD; Rubsamen-Waigmann H; Chemotherapeutisches Forschungsinstitut, Georg-Speyer-Haus,; Frankfurt, Federal Republic of Germany.
The biological properties and efficiency of isolation of different HIV (LAV/HTLV III, ARV, and AAV) subtypes were evaluated by recovering and growing HIV on fresh peripheral human lymphocytes. Cultures for virus isolation were performed from more than 180 German AIDS, ARC, LAS, and virus-exposed asymptomatic patients.
J Med Virol. 1987 Oct;23(2):115-21. Unique Identifier : AIDSLINE MED/88061243
Goudsmit J; de Wolf F; van de Wiel B; Smit L; Bakker M; Albrecht-van Lent N; Coutinho RA; Virology Department, Academic Medical Center of the University of; Amsterdam, The Netherlands.
Sequential sera of 697 homosexual men, participating in a prospective study (1984-1986) of the risk to acquire human immunodeficiency virus (HIV) or AIDS, were tested for antibodies to human T-cell leukaemia virus (HTLV-I) by particle agglutination and immunoblotting. No intravenous drug users were included in this tr
J Med Virol. 1987 Oct;23(2):123-33. Unique Identifier : AIDSLINE MED/88061244
Eizuru Y; Tamura K; Minamishima Y; Ogata K; Tada S; Inoue S; Takeshita M; Kikuchi M; Department of Microbiology, Miyazaki Medical College, Japan.
Cytomegalovirus ( CMV ) infection frequently occurred in patients with malignant lymphoma of T-cell origin, especially with adult T-cell leukemia (ATL). This was evidenced by histopathological examination at autopsy, isolation of CMV, and detection of CMV antibodi
Lancet. 1987 Nov 21;2(8569):1175-8. Unique Identifier : AIDSLINE MED/88064596
McDonald EM; Mann AH; Thomas HC; Academic Department of Psychiatry, Royal Free Hospital School of; Medicine, London.
A significant increase in psychiatric morbidity, assessed by standard measures, was demonstrated in a group of patients receiving recombinant alpha-interferon for chronic hepatitis-B virus infection. In some cases the psychiatric symptoms were severe enough to need urgent psychiatric attention. The changes seemed most
Lancet. 1987 Nov 28;2(8570):1260-3. Unique Identifier : AIDSLINE MED/88064654
Harding TW; University Institute of Legal Medicine, Geneva.
A survey carried out in 17 countries on behalf of the Council of Europe shows how prison doctors and administrations have reacted to the AIDS epidemic in ways that are not always scientifically and ethically sound. The pressing need to control HIV infection in prison, to counsel and support seropositive prisoners, to
When immunophenotyping is used for diagnosis, it is essential to use panels of antibodies, rather than a single marker for a specific tumor type. There is virtually no single marker that is absolutely diagnostic and completely reliable for any particular neoplasm. For the most important clinical differential diagnoses
Hasui K; Sato E; Tokudome T; Tokunaga M; Setoyama M; Tashiro M; Second Department of Pathology, School of Medicine, Kagoshima; University, Japan.
In the skin lesions of 16 adult T-cell leukemia/lymphoma (ATLL) and 13 mycosis fungoides (MF), morphological features of cutaneous infiltrates and their cell kinetics were evaluated through microphotometry of nuclear DNA content and nuclear size on Feulgen-stained sections. Lymphomas comprising some giant cells with i
Ovcak S; Drinovec B; Likar M; Reference laboratory for the diagnosis of AIDS, Medical Faculty,; University Edvard Kardelj, Ljubljana, Yugoslavia.
We compared four commercially available enzyme immunoassay (EIA) kits for the detection of HIV antibodies using immunoblot analysis as a confirmatory test. The kits gave satisfactory results as far as sensitivity and specificity are concerned as required for the use in the laboratories of blood banks. For the sera of
Southern Reporter, 2d Series. 1987 Jan 5 (date of decision);500:533-538. Unique Identifier : AIDSLINE KIE/24155
The petitioner received 51 units of blood after an automobile accident. Fourteen months later he was diagnosed as having AIDS. In his action against the driver, the petitioner sought to prove that he contracted AIDS from the blood transfusions and that the driver was not only liable for his injuries sustained during t
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