Evidence for activation of complement in patients with AIDS related complex (ARC) and/or lymphoadenopathy syndrome (LAS). NLM AIDSLINE Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

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Evidence for activation of complement in patients with AIDS related complex (ARC) and/or lymphoadenopathy syndrome (LAS).

Clin Exp Immunol. 1987 Dec;70(3):500-7. Unique Identifier : AIDSLINE MED/88136297
Perricone R; Fontana L; de Carolis C; Carini C; Sirianni MC; Aiuti F; Department of Allergology and Clinical Immunology, University of; Rome La Sapienza, Italy.

Abstract: The complement system was examined in 16 patients with AIDS-related complex (ARC) (n = 5) and/or lymphoadenopathy syndrome (LAS) (n = 11). Of these patients 62.5% showed an impairment of classical and/or alternative pathway activity associated with the presence of cleavage fragments of C3 and/or B and a significant reduction of many complement factors. The data indicate pathological complement activation in these patients through the classical and/or alternative pathway. Complement activation was more severe in patients with ARC than in those with LAS, and greater in drug abusers than homosexuals. The lack of efficient complement in the patients can be considered an 'acquired complement deficiency' with possible importance in the failure to combat the HIV attack.
Keywords: Adult AIDS-Related Complex/*IMMUNOLOGY Complement/ANALYSIS *Complement Activation Complement Pathway, Alternative Complement Pathway, Classical Female Hemolysis Homosexuality Human Male Substance Abuse/IMMUNOLOGY Support, Non-U.S. Gov't JOURNAL ARTICLE

KWDadultaids-relatedcomplex/KWDimmunologycomplement/analysisKWDcomplementactivationcomplementpathway,alternativecomplementpathway,classicalfemalehemolysishomosexualityhumanmalesubstanceabuse/immunologysupport,non-uKWDsKWDgov'tjournalarticle
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M8860499

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