Dordrecht ; Boston : Nijhoff ; Norwell, MA, U.S.A. : Sold and distributed in the U.S.A. and Canada by Kluwer Academic Publishers, c1988 vi, 145 p Unique Identifier : AIDSLINE CAT/8804860
Cancer Nurs; 10(Suppl 1):88-90 1987. Unique Identifier : AIDSLINE ICDB/88645120
Wells RJ; Oncology Nursing, Royal Coll. of Nursing, London, UK
The characteristics (eg, the causative agent, mode of transmission, and public impact) of acquired immune deficiency syndrome (AIDS) are reviewed briefly, and several activities are described that nurses and other health professionals can employ to help protect the public from AIDS. The routes of transmission of the h
Pontani DR; Rutgers, The State Univ. of NJ, New Brunswick, NJ
Two compounds, crisamicin A and amphotericin B methyl ester (AME) of known antimicrobial activity were tested as biological response modifiers and antiviral agents. Immunomodulating activity was determined in both humoral and cell-mediated systems. The induction of antibody synthesis in culture with primed spleen cell
Boll Ist Sieroter Milan. 1987;66(3):194-7. Unique Identifier : AIDSLINE MED/88134588
Mauro L; Ciccia M; Romeo MA; Di Gregorio F; Sciacca S; Maccarrone S; Istituto di Igiene e Medicina Preventiva, Universita degli Studi; di Catania.
The prevalence of anti-LAV/HTLV III antibodies in serum samples of individuals at high risk for AIDS and of healthy individuals living in the province of Catania is reported. Serum samples were collected over the period 1983-86 from 220 drug addicts adults, 339 from multitransfused thalassemia patients, 71 from hemoph
Boll Ist Sieroter Milan. 1987;66(3):235-8. Unique Identifier : AIDSLINE MED/88134595
Schettini F; De Mattia D; Fumarola D; Pollice L; Institute of Clinical and Preventive Pediatrics, University of; Bari, School of Medicine, Italy.
Lymphoadenopathic Syndrome (LAS), diagnosed also with histologycal studies, is described in a polytransfused 11-year old boy affected by beta-thalassemia major. After three days of the admission he suffered a serious acute diarrhea by Aeromonas hydrophila, an opportunistic enteric bacteria demonstrated, up to date, in
Boll Ist Sieroter Milan. 1987;66(3):239-42. Unique Identifier : AIDSLINE MED/88134596
Calzavara-Pinton P; Cattaneo R; Franceschini F; Airo P; Divisione di Dermatologia, Spedali Civili di Brescia, Italy.
Kaposi s Sarcoma (KS) in young individuals is unusual and most often associated with cellular immunodeficiency caused by infective or other neoplastic diseases. It has recently been highly associated with the Acquired Immunodeficiency Syndrome (AIDS). We report the case of a heterosexual 29 year aged man with no evide
Perricone R; Fontana L; de Carolis C; Carini C; Sirianni MC; Aiuti F; Department of Allergology and Clinical Immunology, University of; Rome La Sapienza, Italy.
The complement system was examined in 16 patients with AIDS-related complex (ARC) (n = 5) and/or lymphoadenopathy syndrome (LAS) (n = 11). Of these patients 62.5% showed an impairment of classical and/or alternative pathway activity associated with the presence of cleavage fragments of C3 and/or B and a significant re
Hadden JW; Program of Immunopharmacology, University of South Florida; Medical College, Tampa 33612.
The current status and future prospects of the immunotherapy of cancer, infection, and autoimmunity are reviewed briefly. Progress in treating the immunodeficiency of cancer with thymic hormones and drugs such as levamisole and lentinan has produced some degree of remission stabilization. Interferon, interleukin II, a
Weyer J; Mathematics Institute, University of Cologne.
Using a nonlinear curve fitting method we calculate the incidence of AIDS cases through a study of reported data on cumulative AIDS cases. The method allows one to estimate the expected value of the incubation time, which happens to be about 11 years, if the intervals of observation are sufficiently large (greater tha
1160 stool specimens, from 160 severely immunocompromised patients, from 70 adults and 180 children with acute diarrhoea and from 60 controls without diarrhoea and without evidence of immunocompromising underlying disorders, were examined for Cryptosporidium excretion. Only two children (1.1%) (one with previous conta
Grief GL; Porembski E; University of Maryland, School of Social Work & Community; Planning, Baltimore 21201.
When an I.V. drug abuser has AIDS, the impact on significant others (parents, lovers, siblings, and friends) can be devastating. Yet little is known about this portion of the population that often provides the bulk of the physical and emotional caregiving to the person with AIDS. This article provides a case example o
Capanna AH; LaMancusa J Jr; Erculei F; Fathie K; Christenson P; Mulkey DA; Division of Neurosurgery, University of Nevada School of; Medicine, Las Vegas.
Two consortial partners presented within 3 weeks of one another with signs and symptoms of neurological dysfunction. Both were found to have acquired immune deficiency syndrome (AIDS) and primary cerebral lymphoma. We found 17 case reports of primary central nervous system (CNS) lymphoma in AIDS patients. Ten of these
McNeil DJ; Kinsella TD; Crawford AM; Fritzler MJ; Department of Medicine, Ohio State University, Columbus 43210.
Nine patients who have intermittently exhibited the concurrent triad of arthritis or arthralgia (A), hives or urticaria (H) and angioedema (A), in the absence of associated infection or connective-tissue disease, are reported. The ratio of women to men is 4:1, with no apparent age specificity. The duration of the dise
Nakamine H; Shimizu E; Nishino E; Takenaka T; Maeda J; Hanaoka M; Department of Laboratory Medicine, Wakayama Medical School,; Japan.
A 37-year-old Japanese man was diagnosed as having acquired immunodeficiency syndrome (AIDS) on the basis of a homosexual history, generalized lymphadenopathy, marked decrease of helper/inducer T cells in the peripheral blood, and positive serum antibody (antibodies) against human immunodeficiency virus (human T-lymph
Ann N Y Acad Sci. 1987;511:390-400. Unique Identifier : AIDSLINE MED/88148741
Rossi GB; Verani P; Macchi B; Federico M; Orecchia A; Nicoletti L; Butto S; Lazzarin A; Mariani G; Ippolito G; et al; Laboratory of Virology, Istituto Superiore di Sanita, Rome,; Italy.
Human retroviruses have been detected in supernatants of cultures of Ficoll-enriched lymphocytes from peripheral blood, lymph nodes and bone marrow of (a) 32 out of 42 patients with Acquired Immunodeficiency Syndrome (AIDS), (b) 34 out of 64 patients with AIDS-related Complex (ARC), (c) 9 out of 18 asymptomatic childr
Brain Res Bull. 1987 Dec;19(6):629-33. Unique Identifier : AIDSLINE MED/88150571
Barrera CM; Kastin AJ; Banks WA; Veterans Administration Medical Center, New Orleans, LA 70146.
It is becoming increasingly evident that peptides can cross the blood-brain barrier. The entry into the central nervous system of a commercially available analog of Peptide T, an octapeptide derived from the human immunodeficiency virus envelope glycoprotein 120, was studied in several experiments. It was found that 1
Peters CS; Kathpalia SB; Chittom-Swiatlo AL; Kallick CA; Sherer R; Kocka FE; Division of Microbiology, Cook County Hospital-Hektoen Institute; for Medical Research, Chicago, IL 60612.
Several protozoa including Cryptosporidium sp. and Isospora belli were found in a stool specimen from a patient not suspected of having Acquired Immunodeficiency Syndrome (AIDS). As a result of the parasitologic findings, serologic tests were ordered that verified the diagnosis of AIDS. All stool specimens are routine
Mendelson MH; Finkel LJ; Meyers BR; Lieberman JP; Hirschman SZ; Department of Medicine, Mount Sinai Hospital, New York, New York; 10029.
In contrast to toxoplasmosis in non-AIDS immunocompromised hosts, AIDS patients rarely have been reported to be infected at extra-CNS sites. We report the case of a 45-year-old homosexual male with AIDS who presented with pneumonitis caused by Toxoplasma gondii following a previous illness consistent with CNS toxoplas
The first open reading frame of the HIV genome has been identified as the gag gene. The proteins encoded by this gene are p17 as the amino-terminal protein, p24 as the middle peptide, and p15 as the carboxyl-terminal end. A monoclonal antibody recognizing an antigenic determinant on a fragment of p15 has been develope
AIDS Res Hum Retroviruses. 1987 Fall;3(3):283-302. Unique Identifier : AIDSLINE MED/88134684
Nara PL; Hatch WC; Dunlop NM; Robey WG; Arthur LO; Gonda MA; Fischinger PJ; Virus Control Unit, National Cancer Institute-Frederick Cancer; Research Facility, MD 21701.
A simple, rapid, quantitative syncytium-forming microassay for the detection of human immunodeficiency virus (HIV-I) isolates is described. A virus-syncytial sensitive clone of CEM cells (CEM-SS) was identified and made adherent to flat bottom 96-well microtiter dishes. Following the addition of virus, these cells dev
Acute encephalopathy was associated with the presence of human immunodeficiency virus type I (HIV I) antigen and seroconversion to anti-HIV I in a 27-year-old homosexual man. Examination of consecutive sera from the patient revealed circulating interferon (IFN) alpha which became detectable with the appearance of HIV
Kerr SJ; Dept. of Biochemistry, Biophysics, and Genetics, Univ. of Colo.; Health Sciences Center, Denver 80262.
The synthetic nucleoside, ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide), a broad spectrum antiviral agent currently being tested in clinical studies with AIDS patients; and mycophenolic acid, a non-nucleoside inhibitor of inosinate (IMP) dehydrogenase, are effective inducers of terminal differentiati
AIDS Res Hum Retroviruses. 1987 Fall;3(3):245-52. Unique Identifier : AIDSLINE MED/88134681
Gonzalez-Scarano F; Waxham MN; Ross AM; Hoxie JA; Department of Neurology, University of Pennsylvania Medical; Center, Philadelphia.
Cell fusion is a characteristic cytopathic effect induced by the human immunodeficiency virus (HIV) that leads to the formation of syncytia between infected lymphocytes. Although this process has been shown to occur following the specific binding of the 110-120 kD externalized envelope molecule of the virus with the C
Valesini G; Barnaba V; Benvenuto R; Balsano F; Mazzanti P; Cazzola P; Instituto Clinica Medica I, University of Rome La Sapienza,; Milan, Italy.
Thymomodulin is a calf thymus acid lysate capable of inducing T lymphocyte maturation. Fifteen patients with HIV infection at different stages according to the Walter Reed classification were treated with 60 mg/day of thymomodulin syrup for more than 50 days. Two WR6B subjects had clinical and immunological parameters
Basing on routine laboratory diagnosis of serum antibodies to the human immunodeficiency virus (HIV-1) in the years 1985 and 1986, the monthly detection rate of infection amounts to 50 persons on an average in the region of Frankfurt/FRG. The relation of female to male persons changed from 1:7 to 1:3 during one year.
Barnert J; Behr W; III. Medizinische Klinik, Zentralklinikum, Augsburg.
We investigated the state of humoral and cellular immunity of 16 patients (eight women, eight men, aged 16 to 80 years), who had suffered from extraintestinal manifestations of infections with enteritis salmonellae. Four patients were examined during the acute state of the disease, the others one to three years therea
Yoshiyama H; Kobayashi N; Matsui T; Nakashima H; Kajii T; Yamato K; Kotani S; Miyoshi I; Yamamoto N; Department of Virology and Parasitology, Yamaguchi University; School of Medicine, Japan.
HIVYU-6 and HIVYU-7 were isolated from an acquired immune deficiency syndrome patient (MK) and his asymptomatic sexual partner (MM), respectively. YU-6 readily infected not only peripheral lymphocytes from normal individuals but also human T-cell lines such as H9, HUT-78, MOLT-4 and MT-4; YU-7, on the other hand, coul
Richman DD; Department of Pathology, University of California San Diego; 92093.
The antiviral activities of various dideoxynucleosides against LAV strains of human immunodeficiency viruses type 1 (HIV-1) and type 2 (HIV-2) were evaluated. Significantly more 3 -azido-3 -deoxythymidine was required to inhibit the replication of HIV-2 than HIV-1 in three human cell lines. HIV-2 also appeared more re
AIDS Res Hum Retroviruses. 1987 Fall;3(3):333-40. Unique Identifier : AIDSLINE MED/88134688
McBride JH; Howanitz PJ; Rodgerson DO; Miles J; Peter JB; Department of Pathology, UCLA School of Medicine.
We investigated effects of specimen treatment on HTLV-III antibody assay results. Freezing and thawing specimens 10 times did not increase specimen mean absorbance (A) values measured by the Abbott immunoenzymometric assay (IEMA). Heating blood donor serum specimens at 56 degrees C for at least 10 min inactivates viru
Mertens T; Institut fur Virologie, Universitat zu Koln.
Great success in the control of infectious diseases has been achieved by vaccination, and especially for virus infections immunization will remain of great significance. Knowledge of the epidemiology of a virus infection, an optimum vaccination strategy as well as the feasibility of a vaccination programme are importa
Thomson DA; Department of Anaesthesia, University of Basel/Kantonsspital,; Switzerland.
While the direct effects of anesthesia on immunological competence have not yet been fully elucidated, it is clear that the use of certain anesthetics and anesthetic procedures contributes to reduced immune function, as demonstrated by such clinical markers as increased infection and tumor growth. This review evaluate
Thymomodulin (Ellem Industria Farmaceutica spa, Milan, Italy ) is a calf thymus acid lysate with immunomodulating activities. It is composed of several peptides with a molecular weight range of 1-10kD. Extensive studies in animal systems showed that Thymomodulin exhibited no, or very
Antonian L; Shinitzky M; Samuel D; Lippa AS; Matrix Research Laboratories, Inc., Fort Lee, NJ 07024.
AL721, which is a novel lipid mixture extracted from egg yolks, is believed to be a therapeutic pharmacologic agent. AL721 interacts with membranes of various types of cells with a common mode of action. AL721 modifies cellular membrane composition and fluidity through passive extraction and/or exchange of cholesterol
Wiest PM; Wiese K; Jacobs MR; Morrissey AB; Abelson TI; Witt W; Lederman MM; Department of Medicine, Case Western Reserve University,; Cleveland, Ohio.
A 31-year-old man with AIDS developed a necrotic lesion on his nasal septum due to Alternaria alternata. Excision and treatment with amphotericin B resulted in cure. This case expands the spectrum of opportunistic pathogens that infect patients with AIDS. Visceral and mucosal infections due to Alternaria have been rep
Gander RM; LaRocco MT; Department of Pathology and Laboratory Medicine, University of; Texas Health Science Center at Houston.
Persistent shigellosis, due to Shigella flexneri resistant to multiple antibiotics, developed in a 40-yr-old homosexual man with human immunodeficiency virus infection. The Shigella strain demonstrated resistance to ampicillin, tetracycline, and trimethoprim-sulfamethoxazole. Although Shigella flexneri isolates resist
Colebunders R; Francis H; Mann JM; Bila KM; Kandi K; Lebughe I; Gigase P; Van Marck E; Macher AM; Quinn TC; et al; Project Syndrome d'ImmunoDeficit Acquit, Department of Public; Health, Kinshasa, Zaire.
In Europe and in the United States , bilateral parotid gland swelling has been observed as a sign of human immunodeficiency virus (HIV) infection in children, but it has not been associated with HIV infection in adults. We observed a chronic parotid gland swelling in nine HIV-seropositi
Nolte FS; Poole RM; Murphy GW; Clark C; Panner BJ; Department of Microbiology and Immunology, University of; Rochester Medical Center, New York 14642.
A case of proctitis and fatal septicemia caused by Plesiomonas shigelloides in a 42-year-old bisexual male is reported. The medical history of the patient was significant for an aortic valve replacement 3 years before but was otherwise unremarkable. A serum specimen obtained at autopsy was negative for antibody to hum
Feremans WW; Huygen K; Menu R; Farber CM; de Caluwe JP; van Vooren JP; Marcelis L; Andre L; Brasseur M; Bondue H; et al; Laboratory of Pathology and Electron Microscopy, Free University; of Brussels, Belgium.
The peripheral lymphocytes of 50 cases of human immunodeficiency virus (HIV) infection (13 of acquired immune deficiency syndrome (AIDS), 17 of AIDS related complex (ARC), and 20 healthy carriers) were studied immunoultrastructurally. The prevalence of tubuloreticular structures and tubular confronting cisternae incre
Nambuya A; Sewankambo N; Mugerwa J; Goodgame R; Lucas S; Department of Medicine, Makarere University School of Medicine,; Kampala.
Sixteen adults presented with lymphadenopathy which was tuberculous on biopsy; they were all seropositive for human immunodeficiency virus (HIV-1), but none had the clinical criteria of the acquired immunodeficiency syndrome (AIDS). The biopsy specimen showed caseating tuberculosis, with scanty or no visible acid fast
Niedt GW; Prioleau PG; Department of Pathology, New York Hospital-Cornell Medical; Center, NY 10021.
A 31-year-old black man with a history of intravenous drug abuse developed a mass in his neck, a biopsy of which revealed Kaposi s sarcoma. The patient underwent radiation therapy, and the mass diminished in size. Approximately 2 months later the patient developed a herpes zoster infection in the left T3 distribution.
Berk MA; Medenica M; Laumann A; Department of Medicine, University of Chicago, IL 60637.
A widespread pruritic papular eruption associated with human immunodeficiency virus has been previously described. Electron microscopic study of lesional skin from a patient who presented with such an eruption showed cytoplasmic tubuloreticular structures in every venular capillary endothelial cell that was studied. T
Weiss LM; Harris C; Berger M; Tanowitz HB; Wittner M; Department of Pathology (Division of Parasitology and Tropical; Medicine), Albert Einstein College of Medicine, Bronx, New York.
JAMA. 1988 Mar 25;259(12):1819-22. Unique Identifier : AIDSLINE MED/88141545
Henry K; Willenbring K; Crossley K; St Paul Division of Public Health, St Paul-Ramsey Medical Center,; MN 55101.
A questionnaire that asked about policies concerning the use of human immunodeficiency virus (HIV) antibody tests was sent in January 1987 to the 200 hospitals in the United States that conduct infectious disease (ID) fellowship training (US ID hospitals) and to all 171 short-term-care
Combined medical, neurological, and serological investigations were carried out in 59 patients infected with human immunodeficiency virus (HIV). In stage I clinical and neuropsychiatric testing did not reveal evidence for HIV encephalitis as diagnosed by local antibody production in CSF. Neuropsychiatric abnormalities
Med J Aust. 1988 Mar 7;148(5):221-5. Unique Identifier : AIDSLINE MED/88142629
Paine SL; Briggs D; AIDS Unit, Health Department Victoria, Melbourne.
A stratified random sample of Victorian medical practitioners was surveyed to determine doctors knowledge of and attitudes to the acquired immunodeficiency syndrome (AIDS). The results of this survey have shown that the knowledge level of a representative sample of medical practitioners in Victoria about AIDS was sat
Mutat Res. 1988 Feb;204(2):277-82. Unique Identifier : AIDSLINE MED/88142934
Das RK; Nayak R; School of Life Sciences, Sambalpur University, Jyoti Vihar,; Orissa, India.
The genotoxic potential of antirabies vaccine (ARV) and tetanus toxoid (TT) inoculated separately and in combination was evaluated by spermatocyte chromosome analysis in mice. Adult males were vaccinated with a dose of 1 ml/kg ARV once daily for 7 days, or with a dose of 1 ml/kg TT once only, or with both (TT being ad
Helgerson SD; Petersen LR; Department of Epidemiology and Public Health, Yale University; School of Medicine, New Haven, Connecticut.
Information was gathered from 657 junior high school and senior high school students in two Connecticut school districts regarding their knowledge of acquired immunodeficiency syndrome (AIDS). Although many students had some factual knowledge about the virus that causes AIDS, many students were misinformed about metho
Hepatic manifestations of acquired immunodeficiency syndrome (AIDS) were analyzed in 76 consecutive patients. Serological markers of hepatitis B were found in 84%. All instances of biopsy-proven chronic hepatitis were associated with delta infection. One patient with intestinal cryptosporidiosis had a severe cholestas
Kaposi s sarcoma is now the second most common AIDS-associated disease, Pneumocystis carinii pneumonia being the commonest. The clinical and radiological picture of bronchopulmonary Kaposi s sarcoma is often indistinguishable from that of nonspecific interstitial pneumonitis. Diagnosis of the sarcoma in the airways, a
Schweiz Med Wochenschr. 1988 Feb 6;118(5):149-53. Unique Identifier : AIDSLINE MED/88145605
Frey-Wettstein M; Leder A; Schutze M; Zurcher Blutspendedienst SRK.
An inquiry amongst blood transfusion services served to establish at 19 the number of known transfusion associated HIV infections in Switzerland . In 12 cases the transfusion of an anti-HIV positive blood unit could be proven retrospectively, while in 7 cases an HIV-infected bl
Am J Gastroenterol. 1988 Mar;83(3):262-6. Unique Identifier : AIDSLINE MED/88147919
Rector WG Jr; Govindarajan S; Horsburgh CR Jr; Penley KA; Cohn DL; Judson FN; Disease Control Service, Denver Department of Health and; Hospitals, University of Colorado Health Sciences Center, Denver.
We measured serum aspartate transaminase (AST) concentration and serum hepatitis B virus (HBV) DNA concentration in homosexual men with chronic HBV infection and a spectrum of immune deficiency as a result of exposure to human immunodeficiency virus (HIV). Serum AST and HBV DNA concentrations were similar in patients
Ann Neurol. 1988 Jan;23(1):49-55. Unique Identifier : AIDSLINE MED/88148918
Janssen RS; Saykin AJ; Kaplan JE; Spira TJ; Pinsky PF; Sprehn GC; Hoffman JC; Mayer WB Jr; Schonberger LB; Division of Viral Diseases, Center for Infectious Diseases,; Atlanta, GA 30333.
To determine if there is a relationship between neurological abnormalities and human immunodeficiency virus (HIV) infection in patients with lymphadenopathy syndrome (LAS), we studied 39 homosexual/bisexual men with LAS (mean duration of LAS, 4.1 years) and 38 homosexual/bisexual men who were seronegative for HIV (con
Keidan AJ; Hamon MD; Franklin IM; Mawson S; Department of Haematology, Medical School, University of; Birmingham, U.K.
Progressive lymphadenopathy in a previously healthy female adult with homozygous sickle cell disease (SCD) was found to be due to infection with the human immunodeficiency virus (HIV). Detailed questioning identified several risk factors for HIV in this apparently low-risk patient. Parenteral therapy and heterosexual
Orenstein JM; Jannotta F; Department of Pathology, George Washington University Medical; Center, Washington, DC 20037.
A wide variety of neurologic conditions associated with the acquired immunodeficiency syndrome (AIDS) have been attributed to human immunodeficiency virus (HIV) infection of the central nervous system (CNS). Tissue samples from the brains of three patients with AIDS, diagnosed as having CNS toxoplasmosis on the basis
Int J Dermatol. 1988 Jan-Feb;27(1):34-5. Unique Identifier : AIDSLINE MED/88153199
Jenkins D Jr; Fisher BK; Chalvardjian A; Adam P; Department of Dermatology, University of Toronto Medical School,; Wellesley Hospital, Ontario, Canada.
Janoff EN; Smith PD; Blaser MJ; Infectious Disease Section, Veterans Administration Medical; Center, Denver, Colorado.
We investigated the ability of patients with AIDS to develop antibody responses to a naturally encountered antigenic stimulus, Giardia lamblia. Using an enzyme-linked immunosorbent assay to detect IgG, IgM, and IgA to G. lamblia trophozoites, we tested sera from 29 patients with AIDS (15 without and 14 with G. lamblia
Chou MJ; Lee TH; Hatzakis A; Mandalaki T; McLane MF; Essex M; Department of Cancer Biology, Harvard School of Public Health,; Boston, Massachusetts 02115.
Sera from hemophiliacs were analyzed for antibodies to human immunodeficiency virus type 1 (HIV-1) by using radioimmunoprecipitation (RIP), western blotting (WB) with nonreducing buffer (NR), and WB with reducing buffer (R). We analyzed envelope gp160, gp120, and gp41; pol gene proteins p64, p53, and p34; and gag gene
Med J Aust. 1988 Mar 21;148(6):282-6. Unique Identifier : AIDSLINE MED/88156709
Morlet A; Guinan JJ; Diefenthaler I; Gold J; Albion Street (AIDS) Centre, Surry Hills, NSW.
The national educational programme on the acquired immunodeficiency syndrome (AIDS) caused a dramatic increase in the number of heterosexual persons who presented for human immunodeficiency virus (HIV) antibody testing at the Albion Street (AIDS) Centre. There was also a marked increase in the number of intravenous dr
Nature. 1988 Mar 17;332(6161):287-8. Unique Identifier : AIDSLINE MED/88156969
Morein B; Department of Virology, National Veterinary Institute, Uppsala,; Sweden.
The immunostimulating complex, or iscom, provides an effective means of presenting antigens to the immune system. Vaccines for influenza, hepatitis B and AIDS are in the offing.
Science. 1988 Mar 18;239(4846):1420-2. Unique Identifier : AIDSLINE MED/88159234
Miller RH; Hepatitis Viruses Section, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892.
The genome of the human immunodeficiency virus (HIV) is known to contain eight open reading frames (ORFs) on the minus strand of the double-stranded DNA replicative intermediate. Data presented here indicate that the DNA plus strand of HIV contains a previously unidentified ORF in a region complementary to the envelop
Gunson HH; Rawlinson VI; National Blood Transfusion Service, Manchester, UK.
Routine screening of blood donations for anti-HIV commenced in the UK during October 1985 and by the end of February 1987 approximately 3.7 million donations had been tested. Seventy-two were confirmed anti-HIV positive, i.e. 0.002%. Of the anti-HIV-positive donors interviewed to date, the majority are young homosexua
Detection of hepatitis B viral DNA (HBV-DNA) is the most reliable test for infectivity of a patient s serum. HBV-DNA was detected by spot hybridization on nylon membrane. HBV-DNA was detected during the first or second week of jaundice in 22/133 (16.5%) sera from patients with acute hepatitis who did not develop chron
Am J Hematol. 1988 Mar;27(3):212-5. Unique Identifier : AIDSLINE MED/88161034
Meisenberg BR; Robinson WL; Mosley CA; Duke MS; Rabetoy GM; Kosty MP; Department of Internal Medicine (Hematology/Oncology), Naval; Hospital, San Diego, CA 92134-5000.
Two male patients with thrombotic thrombocytopenic purpura (TTP) were found to have antibodies to the human immunodeficiency virus (HIV). In one patient, platelet-associated antibody levels were measured serially and were found to be initially elevated, but the levels decreased with initiation of successful therapy. T
Dobs AS; Dempsey MA; Ladenson PW; Polk BF; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21205.
Gonadal, adrenal, and thyroid functions were evaluated in 70 men seropositive for human immunodeficiency virus (HIV) infection, clinically categorized as asymptomatic (n = 19), AIDS-related complex (ARC) (n = 9), or acquired immunodeficiency syndrome (AIDS) (n = 42). Twenty of 40 men (50 percent) with AIDS were hypogo
Rogers PL; Walker RE; Lane HC; Witebsky FG; Kovacs JA; Parrillo JE; Masur H; Clinical Center, and National Institute of Allergy and Infectious; Diseases, Bethesda, Maryland.
In two patients with the acquired immunodeficiency syndrome (AIDS), multiple erythematous cutaneous lesions developed, revealing acid-fast organisms on Fite s stain. Initial culture results on the first patient were negative; however, repeat cultures on hemin-enriched media were positive for Mycobacterium haemophilum.
Am J Public Health. 1988 Apr;78(4):387-93. Unique Identifier : AIDSLINE MED/88161547
Judson FN; Vernon TM Jr; Denver Public Health, CO 80204-4507.
Owing to large differences in the incidence of AIDS (acquired immunodeficiency syndrome) and in public health resources and priorities, the impact of AIDS on state and local health departments has been variable. Nonetheless, health departments everywhere are being held responsible for surveillance and control of the H
Am J Public Health. 1988 Apr;78(4):411-5. Unique Identifier : AIDSLINE MED/88161549
Krieger N; Lashof JC; Department of Biomedical and Environmental Health Sciences,; School of Public Health, University of California, Berkeley; 94720.
Current debates concerning appropriate policy to combat the epidemic of acquired immunodeficiency syndrome (AIDS) have raised critical questions regarding the role that schools of public health and individual public health professionals should play, if any, in AIDS-related policy analysis and social advocacy. In the s
Am J Public Health. 1988 Apr;78(4):443-6. Unique Identifier : AIDSLINE MED/88161555
Lange WR; Snyder FR; Lozovsky D; Kaistha V; Kaczaniuk MA; Jaffe JH; Addiction Research Center, National Institute on Drug Abuse,; Baltimore, Maryland 21224.
Drug abuse treatment programs in six regions of the United States collaborated in a study aimed at monitoring trends in the seroprevalence of human immunodeficiency virus (HIV) antibodies. The wide disparities in HIV seroprevalence in the face of similarities in drug using behavior hav
Am J Public Health. 1988 Apr;78(4):455-9. Unique Identifier : AIDSLINE MED/88161558
Link RN; Feingold AR; Charap MH; Freeman K; Shelov SP; Department of Medicine, New York University School of Medicine,; NY.
To assess the degree of house officers concerns about acquiring AIDS (acquired immunodeficiency syndrome) from their patients, we surveyed 263 medical and pediatric interns and residents in four housestaff training programs affiliated with seven New York City hospitals with large AIDS patient populations; 258 questio
Ann Intern Med. 1988 Apr;108(4):540-6. Unique Identifier : AIDSLINE MED/88161893
Perlman DM; Ampel NM; Schifman RB; Cohn DL; Patton CM; Aguirre ML; Wang WL; Blaser MJ; Medical Service, Veterans Administration Medical Center, Denver,; Colorado.
We identified Campylobacter jejuni infections in four patients infected with the human immunodeficiency virus (HIV); three had persistent and severe C. jejuni infections. Multiple isolates obtained from each patient had the same biochemical and serotypic characteristics, indicating recurrent infection rather than rein
Ann Neurol. 1988;23 Suppl:S17-8. Unique Identifier : AIDSLINE MED/88162146
Janssen RS; Saykin AJ; Kaplan JE; Spira TJ; Pinsky PF; Sprehn GC; Hoffman JC; Mayer WB Jr; Schonberger LB; Division of Viral Diseases, Centers for Disease Control, Atlanta,; GA 30333.
This case-control study of 39 homosexual or bisexual men who were human immunodeficiency virus (HIV)-seropositive and had lymphadenopathy syndrome and 38 HIV-seronegative homosexual or bisexual men indicates an association between neurological and neuropsychological abnormalities and HIV infection in patients with lym
Ann Neurol. 1988;23 Suppl:S24-6. Unique Identifier : AIDSLINE MED/88162163
Rubinow DR; Berrettini CH; Brouwers P; Lane HC; Biological Psychiatry Branch, National Institute of Mental; Health, Bethesda, MD 20892.
As part of a study in progress, neuropsychological tests have been administered to 13 patients with clinical acquired immunodeficiency syndrome, 9 human immunodeficiency virus-seropositive patients, 4 seropositive patients with chronic active hepatitis, 5 seronegative patients with chronic active hepatitis, and 6 heal
Ann Neurol. 1988;23 Suppl:S27-33. Unique Identifier : AIDSLINE MED/88162164
Price RW; Sidtis J; Rosenblum M; Department of Neurology, Memorial Sloan-Kettering Cancer Center,; New York, NY 10021.
The acquired immunodeficiency syndrome (AIDS) dementia complex (ADC) commonly complicates the course of human immunodeficiency virus (HIV) infection and AIDS. Although many of its clinical aspects have recently been brought into clearer focus, and pathogenetic evidence has accrued
Ann Neurol. 1988;23 Suppl:S34-7. Unique Identifier : AIDSLINE MED/88162165
McArthur JC; Cohen BA; Farzedegan H; Cornblath DR; Selnes OA; Ostrow D; Johnson RT; Phair J; Polk BF; Johns Hopkins University School of Medicine, Baltimore, MD 21205.
We have studied cerebrospinal fluid obtained from 38 homosexual or bisexual men participating in a prospective study of the neuropsychological disorders associated with human immunodeficiency virus (HIV) infection. Twenty-two subjects had neuropsychiatric findings and seropositivity, 11 asymptomatic subjects had seroc
A human immunodeficiency virus (HIV-I) was isolated from the brain of a patient with progressive dementia but no obvious immunosuppression. This isolate, designated as HIV-IBR, was molecularly cloned and sequenced, and its long terminal repeat (LTR) and envelope sequences were comp
Ann Neurol. 1988;23 Suppl:S74-7. Unique Identifier : AIDSLINE MED/88162175
Popovic M; Mellert W; Erfle V; Gartner S; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, MD 20892.
The cells responsible for persistence of viral infection in the brains of human immunodeficiency virus type I-positive individuals are most likely mononuclear phagocytes. The infection of other cell types within the brain is presumably the result of close interactions with HIV-I-producing cells of the mononuclear phag
Ann Neurol. 1988;23 Suppl:S78-81. Unique Identifier : AIDSLINE MED/88162176
Gendelman HE; Leonard JM; Dutko F; Koenig S; Khillan J; Meltzer MS; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, MD.
Meythaler JM; Cross LL; Department of Orthopaedics and Rehabilitation, University of; Virginia Medical Center, Charlottesville 22908.
It is estimated that one to two million people in the US have antibodies to the human T-lymphotropic virus Type III/lymphadenopathy-associated virus (HTLV-III/LAV) and are consequently at risk for developing acquired immunodeficiency syndrome (AIDS). As the number of carriers of this infection increases, so does the e
de Clerck LS; Couttenye MM; de Broe ME; Stevens WJ; Department of Immunology, University Hospital Antwerp, Belgium.
We describe a patient in whom the diagnosis of transfusion-associated acquired immunodeficiency syndrome (AIDS) was delayed because her clinical symptoms were similar to those of systemic lupus erythematosus and Sjogren s syndrome and because of a false-negative result on a Western blot test for human immunodeficiency
Blomberg J; Klasse PJ; Department of Medical Microbiology, University of Lund, Sweden.
Electrophoretic immunoblotting (EIB [Western blotting]) has emerged as the major method for verification of seropositivity for human immunodeficiency virus (HIV) and therefore needs to be thoroughly characterized. The specificities of three EIB systems, our own and two commercial systems, were studied with anticellula
Blomberg J; Klasse PJ; Department of Medical Microbiology, University of Lund, Sweden.
Electrophoretic immunoblotting (EIB [Western blotting]), the main method for verification of human immunodeficiency virus (HIV) seropositivity, needs thorough characterization and standardization. We explored the possibilities of quantifying immunoglobulin G (IgG) bound to EIB strips both by densitometry of the peroxi
Montefiori DC; Robinson WE Jr; Schuffman SS; Mitchell WM; Department of Pathology, Vanderbilt University School of; Medicine, Nashville, Tennessee 37232.
A 96-well microtiter infection assay for the human immunodeficiency virus (HIV) is described. The assay utilizes human T-cell lymphotropic virus type I-immortalized MT-2 cells as targets for infection and requires only 4 to 5 days for completion. Cytolysis was quantitated by vital dye uptake of poly-L-lysine-adhered c
Schweiz Med Wochenschr. 1988 Jan 16;118(2):58-64. Unique Identifier : AIDSLINE MED/88145592
Grob PJ; Joller-Jemelka H; Luthy R; Tauber M; Ledergerber B; Bruhwiler J; Fierz W; Departement fur Innere Medizin, Universitatsspital, Zurich.
53 individuals negative for anti-HIV by screening test and 79 individuals positive for anti-HIV were prospectively surveyed for clinical progression and by quantitatively measuring anti-p24 (antibodies against an HIV core protein), anti-gp41 (antibodies against an HIV surface protein) and HIV-(p24) antigen. The patien
Van de Perre P; De Clercq A; Cogniaux-Leclerc J; Nzaramba D; Butzler JP; Sprecher-Goldberger S; AIDS Project, Kigali, Rwanda.
Human immunodeficiency virus (HIV) has been isolated from cervicovaginal secretions from infected women and is thought to be cell associated. To identify which cells harbour viral antigen, we used monoclonal antibodies to OKT4 and a monoclonal antibody directed against HIV p17 core antigen to perform indirect immunofl
Nishanian PG; Ojo-Amaize E; Uittenbogaart CH; Giorgi JV; Department of Microbiology and Immunology, UCLA School of; Medicine 90024-1747.
Standardized samples of target cells expressing viral antigen are necessary to perform reproducible and comparable functional assays for immune responses to human immunodeficiency virus (HIV-1). HIV-infected cultured cell lines show wide variability in the number of HIV-expressing cells and in the amount of viral anti
Am J Public Health. 1988 Apr;78(4):437-8. Unique Identifier : AIDSLINE MED/88161553
Faden RR; Kass NE; Program in Law, Ethics, and Health, John Hopkins School of; Hygiene and Public Health, Baltimore, MD 21205.
Information collected by the National Gay Rights Advocates in 1986 and by the authors in the spring of 1987 was used to determine the extent to which the states currently regulate the practices of the health insurance industry specific to acquired immunodeficiency syndrome (AIDS). Of the 10 states reporting the greate
Am J Public Health. 1988 Apr;78(4):462-7. Unique Identifier : AIDSLINE MED/88161560
McCusker J; Stoddard AM; Mayer KH; Zapka J; Morrison C; Saltzman SP; Division of Public Health, University of Massachusetts, Amherst; 01003.
This study assesses the effects of HIV (human immunodeficiency virus) antibody testing on subsequent (one year) sexual behavior among 270 homosexual men at a Boston community health center, 21 per cent of whom were unaware of their test result. Except for the number of steady partners, the levels of all sexual activit
Ann Neurol. 1988;23 Suppl:S92-4. Unique Identifier : AIDSLINE MED/88162179
Dalakas MC; Yarchoan R; Spitzer R; Elder G; Sever JL; National Institute of Neurological and Communicative Disorders; and Stroke, Bethesda, MD 20892.
A 72-year-old woman with human immunodeficiency virus (HIV)-related axonal polyradiculoneuropathy of the lower extremities was treated with 3 -azido-2 ,3 -dideoxythymidine ( AZT ), 250 mg every 4 hours. Before therapy she had rapidly progressive weaknes
Wood GS; Burns BF; Dorfman RF; Warnke RA; Department of Pathology, Stanford University Medical Center,; California.
Employing a novel panel of monoclonal antibodies, we characterized in detail the quantitative immunopathologic alterations of lymph nodes in a 69-year-old heterosexual man who died of acquired immunodeficiency 1.5 years after transfusion of blood products. Absolute decreases were evident in total T cell, helper T cell
Craighead J; Moore A; Grossman H; Ershler W; Frattini U; Saxinger C; Hess U; Ngowi F; Department of Pathology, University of Vermont, Burlington 05405.
Thirty residents of north-central Tanzania with various forms of Kaposi s sarcoma (KS) were evaluated. The absolute number of peripheral blood OKT4 lymphocytes in patients and Tanzanian control subjects tended to be low (in comparison with healthy young American adults), and many
Kurosawa A; Pollock SC; Collins MP; Kraff CR; Tso MO; University of Illinois Hospital Eye and Ear Infirmary, Chicago.
A 30-year-old homosexual man with a positive serologic test for human immunodeficiency virus and a history of successfully treated disseminated cutaneous sporotrichosis developed a granulomatous uveitis that worsened with topical and subconjunctival steroid therapy. Culture of the aqueous aspirate yielded Sporothrix s
Munck LK; Petersen CS; Bech K; Thomsen AC; Kroon S; Worm AM; Wantzin GL; Gerstoft J; Department of Medical Gastroenterology, Bispebjerg Hospital,; Copenhagen, Denmark.
Forty eight symptomless homosexual men attending a sexually transmitted disease (STD) clinic and found by screening to have hepatitis B surface antigen (HBsAg) were followed up for a median of 10 (range six to 26) months to characterise their liver disease. Initially 33/50 (66%) of the men had increased serum liver en
J Immunol. 1988 Mar 15;140(6):2023-31. Unique Identifier : AIDSLINE MED/88154519
Kovacs JA; Halpern JL; Swan JC; Moss J; Parrillo JE; Masur H; Critical Care Medicine Department, National Heart, Lung, and; Blood Institute, Bethesda, MD 20892.
To increase understanding of Pneumocystis carinii and its interaction with its hosts, Ag specific for rodent and human P. carinii were identified by the immunoblot method after PAGE of P. carinii organism extracts. The m.w. of the major Ag of rat P. carinii were 45,000, 110,000, and a broad band of 49,000 to 64,000, a
Adachi M; Hayami M; Kashiwagi N; Mizuta T; Ohta Y; Gill MJ; Matheson DS; Tamaoki T; Shiozawa C; Hakomori S; Japan Immunoresearch Laboratories, Takasaki.
Ley determinant (Fuc alpha 1----2Gal beta 1----4[Fuc alpha 1----3]GlcNAc beta 1----R) defined by mAb BM-1 is highly expressed in human immunodeficiency virus (HIV)-infected T cell lines and in CD3+ peripheral mature T cells of patients with acquired immune deficiency syndrome (AIDS) or with AIDS-related complex (ARC).
Khillan JS; Deen KC; Yu SH; Sweet RW; Rosenberg M; Westphal H; Laboratory of Molecular Genetics, National Institute of Child; Health and Human Development, Bethesda, MD 20892.
Transgenic mice were generated carrying either the long terminal repeat of Human Immunodeficiency Virus fused to the bacterial chloramphenicol acetyl transferase reporter gene or a control element of the murine alpha A crystallin gene fused to the tat gene of human immunodeficiency virus. By crossing these two strains
Conte R; Giovanardi L; Tazzari PL; De Rosa V; Rodorigo G; Re MC; Servizio di Immunoematologia e Trasfusionale, Universita,; Policlinico S. Orsola, Bologna, Italia.
We tested serum samples from 11 HIV-seropositive and 32 HIV-seronegative Italian patients with hemophilia A or B for the presence of lymphocytotoxic antibodies (LCTAs). No patients had the acquired immune deficiency syndrome and all had received over many years heat-untreated commercial clotting factors. LCTAs directe
Am J Public Health. 1988 Apr;78(4):447-9. Unique Identifier : AIDSLINE MED/88161556
Glass GE; Hausler WJ; Loeffelholz PL; Yesalis CE 3d; Iowa Medical and Classification Center, Iowa Department of; Corrections, Oakdale 52319.
From January 1 to April 30, 1986, all individuals entering the Iowa prison system were tested for antibody to the human immunodeficiency virus (HIV). Sera were collected on 363 newly incarcerated inmates, 389 inmates returning to prison, and 107 forensic psychiatric patients. Three of the 859 serum samples (0.3 per ce
Ann Neurol. 1988;23 Suppl:S58-61. Unique Identifier : AIDSLINE MED/88162170
Cheng-Mayer C; Levy JA; Department of Medicine, University of California, School of; Medicine, San Francisco 94143.
Human immunodeficiency viruses from the brain can be distinguished from peripheral blood isolates by their ability to infect established human cell lines and their sensitivity to serum neutralization. Isolates from the brain and lymph nodes obtained from the same person displayed similar host range tropism and suscept
Ann Neurol. 1988;23 Suppl:S66-70. Unique Identifier : AIDSLINE MED/88162172
Anand R; Neuropsychiatry Branch, National Institute of Mental Health,; Saint Elizabeth's Hospital, Washington, DC 20032.
Human immunodeficiency virus (HIV) has selective T4-cell tropism and is cytocidal to cells with the helper-inducer phenotype. Central nervous system dysfunctions can complicate full-blown acquired immunodeficiency syndrome (AIDS) but can also be present either in isolation or in the context of AIDS-related complex. Re
Biochem Biophys Res Commun. 1988 Mar 15;151(2):788-93. Unique Identifier : AIDSLINE MED/88162900
Carson DA; Haertle T; Wasson DB; Richman DD; Department of Basic and Clinical Research, Scripps Clinic and; Research Foundation, La Jolla, California 92037.
2 ,3 -dideoxyadenosine (ddAdo) has been shown to inhibit the infection of cultured human T lymphoblasts with the human immunodeficiency virus-1 (HIV-1). However, the pathways of ddAdo metabolism in T lymphocytes have not been well defined. We have studied the uptake and degradation of ddAdo in human CEM T lymphoblasts
Murphy RL; Phair JP; Northwestern University Medical School, Chicago, IL.
AIDS is a syndrome that represents the most severe form of infection with the retrovirus HIV. Opportunistic infections, uncommon malignant neoplasms, and intractable immunologic deficiency are hallmarks of AIDS. To date, the syndrome in the U.S. is seen mainly in epidemiologically restricted populations. It appears to
To evaluate the performance of a serological test for human immunodeficiency virus type 1 (HIV-1) infections based on the use of a recombinant envelope gene-derived protein as the antigen, we caused expression of a 1.4-kilobase fragment of HIV.DNA that codes for the complete gp41 transmembrane protein in an Escherichi
Gooderman SF; Bass S; SUNY State College of Optometry, NY 10010.
Recognized in 1981, acquired immune deficiency syndrome or AIDS has become a worldwide epidemic. HIV virus is believed to be the causative agent and acts primarily upon T-helper lymphocytes and nerve tissue, damaging the body s immune system. Ocular and systemic opportunistic infections result. Transmission is primari
McGregor JA; French JI; Spencer NE; Department of Obstetrics/Gynecology, University of Colorado,; Denver 80262.
The frequency and severity of sexually transmitted diseases (STDs) and their sequelae, including sterility, numerous perinatal infections, genital tract neoplasia and possibly death (from ectopic pregnancy, ruptured tuboovarian abscess, human immunodeficiency virus-1 and hepatitis B virus infection), should be acknowl
Schweiz Med Wochenschr. 1988 Jan 23;118(3):100-5. Unique Identifier : AIDSLINE MED/88145594
Krause M; Frei D; Rudlinger R; Keusch G; Joller H; Binswanger U; Department fur Innere Medizin, Universitatsspital, Zurich.
Kaposi s sarcoma (KS) in renal allograft recipients is a rare though serious complication of immunosuppressive treatment. Therapeutic procedures such as surgical excision and local irradiation are inappropriate, since the endothelial-originated tumor is often multicentric. However, systemic treatment such as chemother
Kerman RH; van Buren CT; Lewis RM; Frazier OH; Cooley D; Kahan BD; Department of Surgery, University of Texas Medical School,; Houston 77030.
From July 1982 to August 1986, 137 patients received heart allografts at our transplant (Tx) center. Recipients were treated postoperatively with cyclosporine (CsA) and prednisone (Pred), with a minority of patients receiving CsA, Pred, and azathioprine (Aza) as immunosuppression. The impact of pre-Tx immune factors o
Am Fam Physician. 1988 Feb;37(2):193-8. Unique Identifier : AIDSLINE MED/88147738
Limpert GH; Peacock JE Jr; Bowman Gray School of Medicine, Winston-Salem, North Carolina.
Noncholera vibrios can cause soft tissue infections as well as diarrheal disease. A history of exposure to marine water or shellfish aids in the presumptive diagnosis of these atypical infections. The treatment of choice for Vibrio wound infections is tetracycline, since these organisms often are resistant to penicill
Verdonck LF; de Gast GC; Lange JM; Schuurman HJ; Dekker AW; Bast BJ; Department of Hematology, University Hospital Utrecht, The; Netherlands.
A 22-year-old man who underwent syngeneic bone marrow transplantation (BMT) for acute lymphoblastic leukemia acquired a human immunodeficiency virus (HIV) infection by transfusion of blood products from a donor at risk. The manifestations were acute encephalopathy together with immune thrombocytopenia in the early pos
Peterson LC; Kueck B; Arthur DC; Dedeker K; Brunning RD; Department of Laboratory Medicine and Pathology, Hennepin County; Medical Center, Minneapolis, MN 55415.
This report describes the clinical and pathologic features of four patients with a florid, systemic immunoblastic proliferation. The blood of these patients exhibited a mild to marked leukocytosis with a high percentage of immunoblasts and plasma cells. The bone marrow also was infiltrated extensively by immunoblasts.
Gupta AK; Rasmussen JE; Department of Dermatology, University of Michigan, Ann Arbor.
This report discusses some of the newly described diseases in pediatric dermatology and recent developments in other diseases that are pertinent to this field.
de Groot AC; Weyland JW; Department of Dermatology, Willem-Alexander Hospital,; 's-Hertogenbosch, The Netherlands.
Kathon CG, a cosmetics preservative containing, as active ingredients, 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, appears to be a frequent cause of contact dermatitis in Europe. In the United States , where Kathon CG was introduced some 5 years later, the
Dismukes WE; Department of Medicine, University of Alabama School of Medicine,; Birmingham.
The Cryptococcus has become a major cause of meningitis in patients infected with the human immunodeficiency virus (HIV), and the expression of cryptococcal infection in this population of patients is quite unique. Often the infection is devoid of inflammatory response and is associated with very high antigen and fung
Nature. 1988 Mar 17;332(6161):228-34. Unique Identifier : AIDSLINE MED/88156957
Anderson RM; May RM; McLean AR; Department of Pure and Applied Biology, Imperial College, London; University, UK.
Simple mathematical models of the transmission dynamics of HIV that incorporate demographic and epidemiological processes to assess the potential impact of AIDS on human population growth and structure in developing countries suggest that AIDS is capable of changing population growth rates from positive to negative va
Navarro MD; Pineda JA; Velardo MA; Garcia de Pesquera F; Leal M; Lissen E; Department of Internal Medicine, Virgen del Rocio Hospital,; Sevilla, Spain.
Lorber B; Section of Infectious Diseases, Temple University Health Sciences; Center, Philadelphia, Pennsylvania 19140.
In the 20 years that have passed since I received my medical degree, some of the most evident, striking, and interesting changes in patterns of diseases have occurred among those due to transmissible agents. Among other changes are the recognition of new diseases, new clinical manifestations for old diseases, new ecol
Am J Public Health. 1988 Apr;78(4):381-6. Unique Identifier : AIDSLINE MED/88161546
Allen JR; Curran JW; AIDS Program, Center for Infectious Diseases, Atlanta, GA 30333.
By the end of 1987, almost 50,000 cases of acquired immunodeficiency syndrome (AIDS) will have been reported in the United States . Although the primary epidemiology of the disease has been described, much work remains to be done to complete our understanding of the dynamics of transmis
Am J Public Health. 1988 Apr;78(4):394-410. Unique Identifier : AIDSLINE MED/88161548
Becker MH; Joseph JG; Department of Health Behavior and Health Education, School of; Public Health, University of Michigan, Ann Arbor 48109-2029.
Published reports describing behavioral changes in response to the threat of AIDS (acquired immunodeficiency syndrome) are reviewed. These studies demonstrate rapid, profound, but expectably incomplete alterations in the behavior of both homosexual/bisexual males and intravenous drug users. This is true in the highest
Am J Public Health. 1988 Apr;78(4):418-23. Unique Identifier : AIDSLINE MED/88161550
Rosenberg MJ; Weiner JM; American Social Health Association, Research Triangle Park, NC; 27709.
With increasing competition for resources, health departments are faced with the question of whether to target female prostitutes as a high priority component of AIDS prevention strategy. Prostitutes are considered to be a reservoir for transmission of certain sexually transmitted diseases (STDs). However, a variety o
Am J Public Health. 1988 Apr;78(4):432-6. Unique Identifier : AIDSLINE MED/88161552
Buchanan RJ; Sloan Program in Health Administration, Department of Human; Service Studies, Cornell University, Ithaca, New York 14853.
Medicaid programs are paying for 23 per cent of the health care costs of AIDS patients nationally, and approximately 40 per cent of all AIDS patients will become dependent on Medicaid to pay for their health care. The state Medicaid programs were surveyed by mail for this research in mid 1987 to determine if the state
Ann Neurol. 1988;23 Suppl:S171-3. Unique Identifier : AIDSLINE MED/88162147
Madden DL; Mundon FK; Tzan NR; Fuccillo DA; Dalakas MC; Calabrese V; Elizan TS; Roman GC; Sever JL; National Institute of Neurological and Communicative Disorders; and Stroke, Bethesda, MD.
We have tested sera from patients with multiple sclerosis, matched controls, and those with other neurological diseases, as well as sera from patients with the acquired immunodeficiency syndrome and controls and patients with tropical spastic paraparesis (TSP) and controls for antibody to human T-lymphotropic virus ty
Ann Neurol. 1988;23 Suppl:S19-23. Unique Identifier : AIDSLINE MED/88162152
Epstein LG; Sharer LR; Goudsmit J; Department of Neurosciences, UMD-New Jersey Medical School,; Newark 07103-2757.
A progressive encephalopathy occurs in 30 to 50% of infants and children infected with the human immunodeficiency virus (HIV). The expression of HIV antigen in the cerebrospinal fluid appears to correlate with the clinical occurrence of progressive encephalopathy. The signs of progressive encephalopathy in children wi
Ann Neurol. 1988;23 Suppl:S201-6. Unique Identifier : AIDSLINE MED/88162155
Gardner MB; Department of Medical Pathology, University of California, Davis; 95616.
A neurotropic retrovirus causes a naturally occurring lower-limb paralysis in wild mice, characterized by a noninflammatory spongiform change located primarily in the lower spinal cord. The causative agent is an ecotropic murine leukemia virus, unique to certain wild mice in southern California. The disease is readily
Ann Neurol. 1988;23 Suppl:S54-7. Unique Identifier : AIDSLINE MED/88162169
Petito CK; Department of Pathology (Neuropathology), New York; Hospital-Cornell University Medical College, NY 10021.
Aseptic meningitis, subacute encephalitis, and vacuolar myelopathy are the three diseases of the central nervous system that are specifically related to or associated with human immunodeficiency virus (HIV) infection. HIV encephalitis initially is associated with myelin pallor and gliosis of the centrum semiovale, whi
Br Med J (Clin Res Ed). 1988 Jan 23;296(6617):238-40. Unique Identifier : AIDSLINE MED/88135241
von Sydow M; Gaines H; Sonnerborg A; Forsgren M; Pehrson PO; Strannegard O; Department of Virology, Central Microbiological Laboratory of; Stockholm County Council, Sweden.
Serial blood samples were obtained from 21 homosexuals who had developed symptomatic primary infection with human immunodeficiency virus (HIV) after a median incubation time of 14 days. During the first two weeks after the onset of illness HIV antigen (p24) was detected in the blood by enzyme linked immunosorbent assa
We studied 66 Israeli hemophiliacs for antibodies to HIV in blood samples collected between 1978 and 1985. By May 1985, 2 had AIDS, 2 had ARC, 4 had lymphadenopathy with some immunologic dysfunction, and 58 were asymptomatic. Antibodies to HIV were detected in 40 (60.6%) patients, including all 8 with disease. Presenc
Lederman MM; Carey JT; Schacter B; Aucott J; Ellner JJ; Department of Medicine and Pathology, Case Western Reserve; University, Cleveland, Ohio.
We observed that lymphocytes obtained from healthy persons generally expressed infrequent reactivity with the monoclonal antibody 4D12, an antibody raised against a cell line infected by the human T-lymphotropic virus type I. As had been observed previously, persons bearing HLA-B5 cross-reactive antigens and certain o
NIDA Res Monogr. 1987;76:200-6. Unique Identifier : AIDSLINE MED/88143081
Anglin MD; Brecht ML; Department of Psychiatry, University of California, Los Angeles; 90024.
Data is presented on the prevalence of clinical AIDS and antibodies to the AIDS virus in intravenous drug users. In addition, data from subjects followed over twenty years in a California study on the natural history of narcotics addiction is reported. Information about AIDS attitudes and high risk behavior is related
Grant JA; Bernstein DI; Buckley CE; Chu T; Fox RW; Rocklin RE; Schoenwetter WF; Spector SL; Stafford CT; Stroh JE Jr; et al; Department of Medicine, University of Texas Medical Branch,; Galveston 77550.
The efficacy of terfenadine, a nonsedating H1 antihistamine, in the management of chronic idiopathic urticaria was compared with chlorpheniramine and placebo in a parallel multicenter trial. Subjects with symptoms of hives for 3 days per week for at least 6 weeks were initially screened and admitted if no identifiable
This paper summarises the information given on the 1985 EDTA Registry centre questionnaire which was returned by 82% of 1959 known dialysis and transplant units in 33 European countries. Trends in the use of different forms of renal replacement therapy are discussed, and attention drawn to the discrepancy between the
Lynn WS; Tweedale A; Cloyd MW; Department of Medicine, Duke University, Durham, North Carolina; 27710.
The molecular mechanism(s) by which human immunodeficiency virus (HIV-1) injures a T-cell line was studied. A pathological role for viral env proteins, which are inserted into the plasma membrane, has been previously demonstrated for HIV as well as other retroviruses which are cytopathic. We therefore initiated studie
Leyva WH; Knutsen AP; Joist JH; Department of Pathology, St. Louis University School of Medicine,; Missouri.
The eradication of a high-response Factor VIII inhibitor in patients with severe hemophilia A is extremely rare even with prolonged immunosuppressive therapy. This report presents a patient with severe hemophilia A, in whom the disappearance of such an inhibitor coincided with the development of the acquired immunodef
Am J Public Health. 1988 Apr;78(4):424-9. Unique Identifier : AIDSLINE MED/88161551
Rowe MJ; Ryan CC; State AIDS Policy Center, Intergovernmental Health Policy; Project, George Washington University, Washington DC 20006.
The State AIDS Policy Center at the Inter-governmental Health Policy Project (IHPP) at George Washington University surveyed all 50 states to determine state AIDS (acquired immunodeficiency syndrome) expenditures, without Medicaid or federal funds, for fiscal 1984-88. During this period, state-only expenditures increa
Am J Public Health. 1988 Apr;78(4):439-42. Unique Identifier : AIDSLINE MED/88161554
Stehr-Green JK; Holman RC; Jason JM; Evatt BL; Division of Host Factors, Centers for Disease Control, Atlanta,; GA 30333.
Between January 1, 1981 and September 4, 1987, 407 cases of hemophilia-associated acquired immunodeficiency syndrome (AIDS) had been reported to the Centers for Disease Control. The number of cases diagnosed each year nearly doubled, except in 1986, when cases increased only 50 per cent. Demographic characteristics of
Am J Public Health. 1988 Apr;78(4):450-4. Unique Identifier : AIDSLINE MED/88161557
Eisenstaedt RS; Getzen TE; Department of Medicine, Temple University School of Medicine,; Philadelphia, PA.
The costs and benefits of screening blood donors for antibody to human immunodeficiency virus (HIV) are assessed. Total costs, including testing, discarding processed blood, marginal donor recruiting, notifying and evaluating positive donors, are $36,234,000 annually for 10 million donors in 1986. Screening these dono
Ann Intern Med. 1988 Apr;108(4):595-608. Unique Identifier : AIDSLINE MED/88161905
Murray HW; Division of Infectious Diseases, Cornell University Medical; College, New York, New York.
Recent research on human macrophage activation has reemphasized the critical role of the lymphokine-secreting T cell in converting quiescent macrophages to efficient microbicidal phagocytes. Interferon-gamma, a key lymphokine secreted by antigen-triggered T4+ helper cells, is capable of inducing the macrophage to act
Eagleton MC; Whelan CA; Sarsfield P; Carr B; Temperley IJ; Feighery C; Department of Immunology, St. James' Hospital, Dublin, Ireland.
This study was established to examine the longitudinal consequences of F VIII therapy on immune function in 24 patients with haemophilia A. Antibodies to the human immunodeficiency virus (HIV) were found in 15 of 16 patients with severe haemophilia and in 2 of 8 patients with mild disease. The principal clinical and i
Grosse Aldenhovel H; Brcanovic M; Kunze R; Marcus-Klinik Bad Driburg, Abteilung fur Neurologie.
In the group of patients studied by us, we found a slight disturbance of the balance between immunoregulatory T helper/inductor lymphocytes and cytotoxic T suppressor lymphocytes which is usually characterised by a 2 to 1 ratio. This disturbance was due to the presence of an absolutely and relatively enhanced quantity
Radolf JD; Kaplan RP; Department of Medicine, University of California, Los Angeles,; School of Medicine.
The case presented here involves a 32-year-old homosexual man with human immunodeficiency virus (HIV) seropositivity and unusual manifestations of secondary syphilis. The patient presented with syphilitic keratoderma and chorioretinitis, and his appearance superficially resembled that of a patient with Reiter s syndro
J Immunol. 1988 Feb 15;140(4):1139-41. Unique Identifier : AIDSLINE MED/88140282
Prince HE; Kleinman S; Williams AE; American Red Cross Blood Services, Los Angeles/Orange Countries; Region, CA 90006.
Serum levels of soluble IL-2R (sIL-2R) were measured in blood donors seropositive for HIV. Approximately one-half (53/101) of these seropositive donors exhibited increased serum sIL-2R levels compared with seronegative controls (n = 65). Further, a significant inverse correlation was observed between serum sIL-2R leve
Fagan EA; Partridge M; Sowray JH; Williams R; Liver Unit, King's College Hospital, London, England.
Several of the common viral agents that can cause hepatitis have been detected in body fluids, including saliva and blood, which may both form important routes for transmission of disease. The viruses most commonly implicated include hepatitis A virus (HAV), hepatitis B virus (HBV), cy
Science. 1988 Mar 4;239(4844):1150-3. Unique Identifier : AIDSLINE MED/88145673
Franza BR Jr; Rauscher FJ 3d; Josephs SF; Curran T; Cold Spring Harbor Laboratory, NY 11724.
The Fos protein complex and several Fos-related antigens bind directly or indirectly to a common sequence element that is similar to the consensus binding site for HeLa cell activator protein 1 (AP-1). This element is present in a negative regulatory sequence in the differentiation-sensitive adipocyte gene, aP2; in a
J Immunol. 1988 Mar 1;140(5):1485-9. Unique Identifier : AIDSLINE MED/88154437
Petit AJ; Tersmette M; Terpstra FG; de Goede RE; van Lier RA; Miedema F; Central Laboratory, Netherlands Red Cross Blood Transfusion; Service, Amsterdam.
We studied the effect of HIV infection on the human monocytic cell line U937. The cell line was infected with cellfree HIV, strain HTLV-IIIB. After 3 wk, a high reverse transcriptase activity was continuously detected in the supernatant of the cell line. Neither cytopathic effects nor changes in cell growth were obser
Presse Med. 1988 Feb 6;17(4):155-60. Unique Identifier : AIDSLINE MED/88158001
Schuller E; Laboratoire de Neuro-Immunologie, Hopital de la Salpetriere,; Paris.
The occurrence of an intrathecal immune reaction, specific to the central nervous system, may reflect either a contemporary systemic immune reaction or a local process directly related to the disease observed. Analysis of this reaction proceeds in 3 stages: the intrathecal production of immunoglobulins is assessed; th
van den Berg H; Vossen JM; Dooren LJ; Afd. Kindergeneeskunde, Academisch Ziekenhuis Leiden.
Infection with the human immunodeficiency virus type I in children causes variable clinical symptoms. It can lead to asymptomatic disease as well as to acquired immunodeficiency syndrome. In this review we describe the clinical picture, the immunological abnormalities, the mode of transmission, and the preventive meas
Antonen J; Ranki A; Valle SL; Seppala E; Vapaatalo H; Suni J; Krohn K; Department of Biomedical Sciences, University of Tampere,; Finland.
During a three-year follow-up study of 235 risk-group people living in Finland , we found a slow increase in the proportion of HIV seropositives (from 9.8% to 14.0%) and a slow but continuous advance in symptoms typical of HIV infect
Ann Intern Med. 1988 Apr;108(4):534-40. Unique Identifier : AIDSLINE MED/88161892
Surbone A; Yarchoan R; McAtee N; Blum MR; Maha M; Allain JP; Thomas RV; Mitsuya H; Lehrman SN; Leuther M; et al; Clinical Oncology Program, National Cancer Institute, Bethesda,; Maryland.
On the basis of observation that acyclovir potentiates the in-vitro antiviral activity of 3-azido-2 ,3 -dideoxythymidine (also known as azidothymidine or zidovudine) against human immunodeficiency virus (HIV), we administered a regimen of azidothymidine and acyclovir to eight pa
Boll Ist Sieroter Milan. 1987;66(3):198-201. Unique Identifier : AIDSLINE MED/88134589
Lilli D; Lorino G; Cipriani P; Berloco P; Pretagostini R; Mancini C; II Cattedra di Microbiologia, Universita La Sapienza, Roma.
We carried out a seroepidemiological study on 63 patients undergoing organ transplantation in order to determine viral markers like CMV , HTLV III, HS and V/Z. The antibodies valuation was carried out by enzyme-linked immunosorbent assays (ELISA-Abbott) and compl
AIDS Res Hum Retroviruses. 1987 Fall;3(3):265-82. Unique Identifier : AIDSLINE MED/88134683
Robinson WE Jr; Montefiori DC; Mitchell WM; Department of Pathology, Vanderbilt University School of; Medicine, Nashville, TN 37232.
The Human Immunodeficiency Virus (HIV), the causative agent of AIDS, is thought to bind to T4+ (CD4+) target cells through the heavily glycosylated gp120 envelope glycoprotein. Plant lectins bind glycoproteins through noncovalent interaction with specific hexose residues; therefore, lectins were evaluated for their ab
AIDS Res Hum Retroviruses. 1987 Fall;3(3):303-15. Unique Identifier : AIDSLINE MED/88134685
Blumberg RS; Paradis TJ; Crawford D; Byington RE; Hirsch MS; Schooley RT; Infectious Disease Unit, Massachusetts General Hospital, Boston.
The human immunodeficiency virus (HIV) may interact with the Epstein Barr virus (EBV) indirectly by effects on the T4 lymphocyte or directly by effects on EBV transformed B lymphocytes. We have confirmed the susceptibility of EBV transformed B lymphocytes to productive HIV infection, and have evaluated the cytotoxic a
Raffanti SP; Chiaramida AJ; Sen P; Wright P; Middleton JR; Chiaramida S; Raritan Bay Medical Center, Perth Amboy, NJ 08861.
We have assessed right and left ventricular function by multigated radionuclide ventriculography in 12 consecutive patients with acquired immunodeficiency syndrome (AIDS) grouped according to the CDC classification system for HIV infection. Results were correlated with clinical, electrocardiographic and echocardiograp
Yamaguchi K; Matutes E; Kiyokawa T; Nishimura Y; Ishii T; Takatsuki K; Catovsky D; Medical Research Council Leukaemia Unit, Royal Postgraduate; Medical School, London.
Serum antibodies against human T cell leukaemia virus type I (HTLV-I) were investigated in 12 patients by four methods: indirect immunoperoxidase staining, indirect immunofluorescence, enzyme linked immunosorbent assay (ELISA), and strip radioimmunoassay based on the Western blotting assay. Seven patients had systemic
J Immunol. 1988 Feb 15;140(4):1123-31. Unique Identifier : AIDSLINE MED/88140280
Klinken SP; Fredrickson TN; Hartley JW; Yetter RA; Morse HC 3d; Laboratory of Immunopathology, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892.
Mice infected with LP-BM5 murine leukemia virus develop lymphadenopathy, splenomegaly, hypergammaglobulinemia, and profound immunosuppression associated with enhanced susceptibility to infection. In this study, molecular genetic analyses of spleen and lymph node cells from infected mice showed the early course of dise
Skolnik PR; Kosloff BR; Hirsch MS; Department of Medicine, Massachusetts General Hospital, Boston; 02114.
Interactions between human immunodeficiency virus type 1 (HIV-1), the etiologic agent of AIDS, and human cytomegalovirus ( CMV ), a frequent opportunistic agent in AIDS, were studied in vitro. Coinfection of H9 cells with HIV-1
JAMA. 1988 Mar 25;259(12):1851-3. Unique Identifier : AIDSLINE MED/88141552
Rietmeijer CA; Krebs JW; Feorino PM; Judson FN; Denver Disease Control Service, CO 80204-4507.
In an in vitro model, 20 condoms containing 0.9 mL of 6.6% (vol/vol) nonoxynol 9 and ten condoms without nonoxynol 9 were tested as physical and chemical barriers against human immunodeficiency virus (HIV). Each condom was mounted on a hollow dildo and placed in a glass cylinder. The HIV inoculum and HIV-free medium w
To establish a reliable procedure for the early detection of central nervous system involvement in HIV infection, paired cerebrospinal fluid and serum samples of 59 patients were analysed. Fifteen were HIV antibody positive without clinical symptoms (stage I), 12 had lymphadenopathy syndrome or AIDS-related complex (s
Med Hypotheses. 1988 Jan;25(1):27-9. Unique Identifier : AIDSLINE MED/88142618
Minarovits J; Segesdi J; Kovacs Z; Foldes I; Microbiological Research Group, National Institute of Hygiene,; Budapest, Hungary.
We have found that genomes of human T cell leukemia-lymphoma virus type I (HTLV-I), BK virus (BKV), and a hepatitis B virus (HBV) DNA sequence integrated into DNA of a hepatoma-derived cell line contain binding sites for nuclear factor 1 (NF-1), a cellular protein which binds to adenoviral and putative cellular origin
We examined the interaction of human immunodeficiency virus (HIV) and herpes group viruses. For this purpose, a chimeric plasmid (pLTR-CAT) was constructed in which the long terminal repeat (LTR) sequences derived from a molecular clone of HIV were fused to a bacterial chloramphenicol acetyltransferase gene (CAT). Tra
Wasserman R; August CS; Plotkin SA; Division of Hematology-Oncology, Children's Hospital of; Philadelphia, PA 19104.
The records of 96 pediatric patients with aplastic anemia or a malignancy who underwent bone marrow transplantation between 1979 and 1986 at The Children s Hospital of Philadelphia were reviewed for laboratory evidence of viral infections. The most common viral diseases identified were herpes simplex virus (HSV),
Pathol Res Pract. 1987 Dec;182(6):729-54. Unique Identifier : AIDSLINE MED/88144156
Waisman J; Rotterdam H; Niedt GN; Lewin K; Racz P; Department of Pathology, New York University School of Medicine,; New York.
This article reviews the findings at postmortem examination on AIDS and separately details the surgical pathology of the gastrointestinal tract, liver, lymph nodes, and skin in these patients. Emphasis is placed upon the light microscopic features of the specimens commonly received in surgical pathology so as the prom
Proc Natl Acad Sci U S A. 1988 Mar;85(5):1457-61. Unique Identifier : AIDSLINE MED/88144456
Nyborg JK; Dynan WS; Chen IS; Wachsman W; Department of Chemistry and Biochemistry, University of Colorado,; Boulder 80309.
Efficient expression of human T-cell leukemia virus type I (HTLV-I) genes requires both host and viral proteins and is dependent on DNA sequences in the proviral long terminal repeats (LTRs). We have used DNase I-protection assays (footprinting) to construct a map of protein-DNA interactions over a 250-nucleotide regi
Proc Natl Acad Sci U S A. 1988 Mar;85(5):1652-6. Unique Identifier : AIDSLINE MED/88144494
Kenney S; Kamine J; Markovitz D; Fenrick R; Pagano J; Lineberger Cancer Research Center, Department of Medicine,; University of North Carolina, Chapel Hill 27514.
Acquired immunodeficiency syndrome patients are frequently coinfected with Epstein-Barr virus (EBV). In this report, we demonstrate that an EBV immediate-early gene product, BamHI MLF1, stimulates expression of the bacterial chloramphenicol acetyltransferase (CAT) gene linked to the human immunodeficiency virus (HIV)
Gastaut JL; Gastaut JA; Pellissier JF; Tapko JB; Finaud M; Delpero JR; Gamby T; Weill O; Carcassonne Y; Service de Neurologie, Hopital de Sainte-Marguerite, Marseille,; France.
Neurologic complications are frequently observed during HIV-related infections and particularly in AIDS. According to the literature, these complications more often pertain to the central nervous system (CNS) than the peripheral nervous system (PNS). A prospective study was carried out in order to determine the freque
Science. 1988 Feb 26;239(4843):1021-3. Unique Identifier : AIDSLINE MED/88145644
Ho DD; Kaplan JC; Rackauskas IE; Gurney ME; Division of Infectious Diseases, Cedars-Sinai Medical Center, Los; Angeles, CA.
Rabbit antisera were raised against three overlapping synthetic peptides with sequence homology to the second conserved domain of the external envelope glycoprotein (gp120) of the human immunodeficiency virus (HIV). All of the antisera immunoprecipitated the envelope glycoprotein. In particular, an antiserum directed
Science. 1988 Mar 11;239(4845):1299-302. Unique Identifier : AIDSLINE MED/88145687
Nabel GJ; Rice SA; Knipe DM; Baltimore D; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
The expression of human immunodeficiency virus (HIV) after T cell activation is regulated by NF-kappa B, an inducible DNA-binding protein that stimulates transcription. Proteins encoded by a variety of DNA viruses are also able to activate expression from the HIV enhancer. To determine how this activation occurs, spec
Ann N Y Acad Sci. 1987;511:207-18. Unique Identifier : AIDSLINE MED/88148720
Dalla-Favera R; Lombardi L; Pelicci PG; Lanfrancone L; Cesarman E; Neri A; Department of Pathology, New York University School of Medicine,; New York 10016.
Ann Neurol. 1988 Jan;23(1):97-9. Unique Identifier : AIDSLINE MED/88148927
Masdeu JC; Small CB; Weiss L; Elkin CM; Llena J; Mesa-Tejada R; Albert Einstein College of Medicine, Montefiore-North Central; Bronx Hospitals, NY.
A 43-year-old man with the acquired immunodeficiency syndrome had clinical evidence of multifocal disease of the brain, but computed tomography was negative. Magnetic resonance imaging revealed multifocal lesions, histologically proven to be caused by cytomegalovirus . Therapy with
Biochem Pharmacol. 1988 Mar 1;37(5):897-903. Unique Identifier : AIDSLINE MED/88149663
Balzarini J; Pauwels R; Baba M; Herdewijn P; de Clercq E; Broder S; Johns DG; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
Cell lines derived from different species show striking differences in their sensitivity to the cytostatic and anti-retrovirus activity, as well as the intracellular metabolism, of 3 -azido-2 ,3 -dideoxythymidine (AzddThd) and 2 ,3 -dideoxycytidine (ddCyd). AzddThd and ddCyd are considerably more cytostatic to human (
Clark JW; Gurgo C; Franchini G; Gibbs WN; Lofters W; Neuland C; Mann D; Saxinger C; Gallo RC; Blattner WA; Environmental Epidemiology Branch, National Cancer Institute,; Bethesda, MD 20892.
As part of epidemiologic studies of human T-lymphotropic virus (HTLV)-I-associated malignancies in Jamaica , the authors evaluated 26 patients with non-Hodgkin s lymphoma for the presence of integrated HTLV-I provirus in their malignant cells. F
Laughon BE; Druckman DA; Vernon A; Quinn TC; Polk BF; Modlin JF; Yolken RH; Bartlett JG; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore.
We studied 388 homosexual or bisexual men from the Baltimore-Washington area to define the spectrum of enteric pathogen carriage in a population at high risk for gay bowel syndrome in association with human immunodeficiency virus infection. Seventy-seven patients with acquired immunodeficiency syndrome, 68 gay men wit
Dictor M; Jarplid B; Department of Pathology, University Hospital of Lund, Sweden.
Changes in the epidemiologic patterns of Kaposi s sarcoma prior to and during the epidemic of acquired immunodeficiency suggest that a virus transmitted similarly to the human immunodeficiency virus (HIV) may be responsible. We propose a natural avian model for Kaposi s sarcoma. Hemangiomatosis of fowls corresponds cl
Altman R; Harrich D; Garcia JA; Gaynor RB; Department of Medicine, University of California, Los Angeles; School of Medicine 90024.
Human T-cell leukemia virus types I (HTLV-I) and II (HTLV-II) are human retroviruses which normally infect T-lymphoid cells. HTLV-I infection is associated with adult T-cell leukemia-lymphoma, and HTLV-II is associated with an indolent form of hairy-cell leukemia. To identify potential transcriptional regulatory eleme
Maio JJ; Brown FL; Department of Cell Biology, Albert Einstein College of Medicine,; Bronx, New York 10461.
Human pluripotential embryonic teratocarcinoma cells differentially expressed gene activity controlled by the human immunodeficiency virus type 1 (HIV-1) and human T-cell leukemia virus type I (HTLV-I) long terminal repeats (LTRs) when differentiation was induced by the morphogen all-trans retinoic acid. The alteratio
Three male patients with the acquired immunodeficiency syndrome revealed perforations of the intestine (jejunum-ileum; colon ascendens; coecum). The cause was necrosis due to cytomegalovirus infection. The characteristic findings were cytomegalic inclusion bodies in endothelial cel
Brown S; Senekjian EK; Montag AG; Department of Obstetrics and Gynecology, University of Chicago,; Pritzker School of Medicine, Illinois.
A case of cytomegalovirus infection of the cervix in a young woman with acquired immunodeficiency syndrome (AIDS) was proved by light microscopy, viral culture, and immunohistochemistry.
Severin M; Hartmann C; University Eye Clinic, Cologne, FRG.
We report on a patient in whom a cytomegalovirus infection occurred in connection with AIDS. Together with the alterations of the fundus typical for cytomegalovirus retinitis, reticular deposits were observed on the corneal endothelium. Specular microscopy showed occasional endothe
Persuy P; Arnott G; Fortier B; Ajana F; Blondel M; Fourrier F; Dewilde A; Maniez-Montreuil M; Service de Neurologie B, CHU Lille.
An acute polyradiculoneuropathy occurred in a 30 years homosexual male. E.L.I.S.A. test and Western Blot showed recent infection by H.I.V. Besides, endogenous reinfestation by cytomegalovirus was found: high concentrations of specific IgG antibodies and presence of the virus in the
Nylander WA Jr; Vanderbilt University School of Medicine, Nashville, Tennessee.
Immunocompromised hosts are a heterogeneous group, including patients receiving transplants, those receiving chemotherapy for malignant disease, and those receiving steroids for autoimmune disease, as well as patients with AIDS. Each group has specific abdominal conditions, and the clinician must be familiar with the
Horowitz B; Piet MP; Prince AM; Edwards CA; Lippin A; Walakovits LA; New York Blood Center, N.Y.
Virus sterilization of blood plasma derivatives by addition of several naturally occurring fatty acids was evaluated using vesicular stomatitis virus and Sindbis virus as markers for lipid-enveloped virus inactivation and human immunodeficiency virus (HIV). Inactivation of greater than or equal to 10(4) tissue culture
Wien Klin Wochenschr. 1988 Jan 22;100(2):33-43. Unique Identifier : AIDSLINE MED/88160187
Aulitzky WE; Hengster P; Tilg H; Schulz T; Dierich M; Huber C; Department for Internal Medicine, University Hospital, Innsbruck.
Interest has focused on cytomegalovirus ( CMV ) infections during recent years for two reasons: First, the number of immunocompromised patients with CMV infections has risen continuously and, secondly, recent advances in basic
Ann Intern Med. 1988 Apr;108(4):585-94. Unique Identifier : AIDSLINE MED/88161904
Jacobson MA; Mills J; Department of Medicine, University of California, San Francisco.
Life-threatening opportunistic cytomegalovirus infection is a complication of the acquired immunodeficiency syndrome (AIDS) that occurs in 7.4% or more of patients with AIDS. Cytomegalovirus retinitis, colitis, esophagitis, and gastritis are the commonest manifestations of severe c
Ann Neurol. 1988;23 Suppl:S101-7. Unique Identifier : AIDSLINE MED/88162133
Ringler DJ; Hunt RD; Desrosiers RC; Daniel MD; Chalifoux LV; King NW; New England Regional Primate Research Center, Harvard Medical; School, Southborough, MA 01772.
Simian immunodeficiency virus (SIV) is a lentivirus with morphological and antigenic similarities to human immunodeficiency virus, the causative agent of acquired immunodeficiency syndrome (AIDS) of humans. Macaque monkeys infected with SIV show profound immunological impairment, clinically characterized by multiple o
Ann Neurol. 1988;23 Suppl:S108-12. Unique Identifier : AIDSLINE MED/88162134
Sharer LR; Baskin GB; Cho ES; Murphey-Corb M; Blumberg BM; Epstein LG; Department of Pathology, UMD-New Jersey Medical School, Newark; 07103.
The simian immunodeficiency virus (SIV) is closely related to the human immunodeficiency virus (HIV) in genomic organization and morphology. More important, SIV and HIV are both primate lentiviruses that cause transmissible immunodeficiency and encephalitis, with an apparently increased virulence in the immature host.
Ann Neurol. 1988;23 Suppl:S185-7. Unique Identifier : AIDSLINE MED/88162150
Liberski PP; Rodgers-Johnson P; Char G; Piccardo P; Gibbs CJ Jr; Gajdusek DC; Laboratory of Central Nervous System Studies, National Institute; of Neurological and Communicative Disorders and Stroke, Bethesda,; MD 20892.
Viral-like particles morphologically identical to human T-lymphotropic virus type I or II, but distinct from human T-lymphotropic virus type III, have been seen by electron microscopy in spinal cord tissue from a Jamaican tropical spastic paraparesis patient who was known to be positive for human T-lymphotropic virus
Ann Neurol. 1988;23 Suppl:S211-2. Unique Identifier : AIDSLINE MED/88162159
Brady RO; O'Neill RR; Developmental and Metabolic Neurology Branch, National Institute; of Neurological and Communicative Disorders and Stroke, Bethesda,; MD 20892.
Ann Neurol. 1988;23 Suppl:S38-48. Unique Identifier : AIDSLINE MED/88162166
Dalakas MC; Pezeshkpour GH; National Institute of Neurological and Communicative Disorders; and Stroke, Bethesda, MD 20892.
The types of neuromuscular diseases associated with human immunodeficiency virus (HIV) infection are described. Our classification includes: (1) six subtypes of peripheral neuropathies--namely, acute Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuropathy, mononeuritis multiplex, an axonal, predomin
Ann Neurol. 1988;23 Suppl:S4-6. Unique Identifier : AIDSLINE MED/88162167
Elder GA; Sever JL; Infectious Diseases Branch, National Institute of Neurological; and Communicative Disorders and Stroke, Bethesda, MD 20892.
Neurological disease occurs frequently in patients infected with the human immunodeficiency virus. Disorders may affect either the central or peripheral nervous systems and may be the presenting manifestation of human immunodeficiency virus-related disease. Opportunistic infections and lymphomas are major causes of ce
Ann Neurol. 1988;23 Suppl:S49-53. Unique Identifier : AIDSLINE MED/88162168
Parry GJ; Department of Neurology, Hahnemann University Hospital,; Philadelphia, PA 19102.
Peripheral neuropathies may complicate all stages of infection with human immunodeficiency virus (HIV). Acute inflammatory demyelinating polyneuropathy, sensory ganglioneuritis, and acute cranial nerve palsy all may occur 2 to 3 weeks after acute HIV infection. Acute inflammatory demyelinating polyneuropathy, chronic
Ann Neurol. 1988;23 Suppl:S7-12. Unique Identifier : AIDSLINE MED/88162173
Levy RM; Bredesen DE; Rosenblum ML; Division of Neurological Surgery, Northwestern University Medical; Center, Chicago, IL 60611.
Central nervous system disease related to the acquired immunodeficiency syndrome (AIDS) includes both those illnesses arising from primary human immunodeficiency virus infection and those secondary to opportunistic processes. Ten percent of AIDS patients present with neurological illness; nearly 40% have significant n
Ann Neurol. 1988;23 Suppl:S71-3. Unique Identifier : AIDSLINE MED/88162174
Pert CB; Smith CC; Ruff MR; Hill JM; Clinical Neuroscience Branch, National Institutes of Mental; Health, Bethesda, MD 20892.
The CD4 molecule was originally described as a marker for a subset of lymphocytes; however, recent work has shown that a similar, if not identical, molecule is present on human brain. We have realized that this cell-surface recognition molecule is normally modulated by vasoactive intestinal peptide (VIP), one of the 5
Ann Neurol. 1988;23 Suppl:S82-7. Unique Identifier : AIDSLINE MED/88162177
Yarchoan R; Thomas RV; Grafman J; Wichman A; Dalakas M; McAtee N; Berg G; Fischl M; Perno CF; Klecker RW; et al; National Cancer Institute, Bethesda, MD 20892.
3 -Azido-2 ,3 -dideoxythymidine ( AZT ) has been administered to 7 patients with human immunodeficiency virus-associated neurological disease: 3 with dementia , 2 with pe
Ann Neurol. 1988;23 Suppl:S88-91. Unique Identifier : AIDSLINE MED/88162178
Cornblath DR; Department of Neurology, Johns Hopkins University School of; Medicine, Baltimore, MD 21205.
Neuromuscular disorders are increasingly being reported in individuals with human immunodeficiency virus (HIV) infection. The majority of these disorders resemble diseases occurring in HIV-seronegative patients and include inflammatory demyelinating polyneuropathies, multiple mononeuropathies, and polymyositis. In HIV
Ann Neurol. 1988;23 Suppl:S95-100. Unique Identifier : AIDSLINE MED/88162180
Narayan O; Kennedy-Stoskopf S; Zink MC; Department of Neurology, Johns Hopkins University School of; Medicine, Baltimore, MD 21205.
The biological properties of the ruminant animal lentiviruses, visna and caprine arthritis-encephalitis viruses, closely resemble those of their human counterparts, the human immunodeficiency viruses (HIV). All of these viruses are morphologically identical and are disseminated from host to host in nature during excha
Biochem Biophys Res Commun. 1988 Feb 29;151(1):608-14. Unique Identifier : AIDSLINE MED/88162869
Birnbaum GI; Lin TS; Prusoff WH; Division of Biological Sciences, National Research Council of; Canada, Ottawa, Canada.
The structure and conformation of 2 ,3 -dideoxycytidine, a potent inhibitor of the human immunodeficiency virus, was determined by X-ray crystallography. The nucleoside crystallizes in the tetragonal space group P4(1)2(1)2 with cell dimensions a = b = 8.698(4) and c = 26.155(9) A. Atomic parameters were refined by ful
AIDS Res Hum Retroviruses. 1987 Fall;3(3):317-22. Unique Identifier : AIDSLINE MED/88134686
Kanki PJ; Allan J; Barin F; Redfield R; Clumeck N; Quinn T; Mowovondi F; Thiry L; Burny A; Zagury D; et al; Department of Cancer Biology, Harvard School of Public Health,; Boston, MA.
We studied 1508 individuals from Zaire , Burundi , Tanzania , Zambia , Kenya , and Cameroon for a
Cancer Genet Cytogenet. 1988 Feb;30(2):191-200. Unique Identifier : AIDSLINE MED/88135587
Nishino K; Department of Hematology, Nagasaki University School of Medicine,; Japan.
Chromosome analysis was performed on nine patients with subclinical adult T-cell leukemia (pre-ATL), who were asymptomatic ATL virus carriers. Fewer than 30% of their peripheral blood leukocytes were abnormal T-lymphocytes with nuclear abnormalities. ATL-associated antigen (ATLA) and anti-ATLA antibody were found in a
Kobayashi S; Yoshida T; Hiroshige Y; Matsui T; Yamamoto N; Department of Virology and Parasitology, Yamaguchi University; School of Medicine, Japan.
Human T-cell leukemia virus type I (HTLV-I) transmission during blood transfusion can be prevented by screening for and eliminating blood containing anti-HTLV-I antibodies. For this purpose, we evaluated two commercial test kits for HTLV-I antibodies, Serodia-ATLA (particle agglutination assay [PA]) and Eitest-ATL (en
Matsuoka M; Hagiya M; Hattori T; Asou N; Maeda S; Shimada K; Tsai SC; Sakano H; Takatsuki K; Second Department of Internal Medicine, Kumamoto University; Medical School, Japan.
Rearrangements of T cell receptor beta and gamma chain (T beta and T gamma) genes were analyzed by Southern blot method in samples from 30 patients with adult T cell leukemia (ATL) and 17 patients with non-ATL T cell neoplasms. The DNA probes used were the constant and joining region of T beta gene and the joining reg
Lancet. 1988 Mar 5;1(8584):520-1. Unique Identifier : AIDSLINE MED/88142262
Stehr-Green JK; Jason JM; Evatt BL; Division of Host Factors, Centers for Disease Control, Atlanta,; GA 30333.
The Centers for Disease Control (CDC) revised the surveillance case definition for acquired immunodeficiency syndrome (AIDS) in August, 1987. To determine the impact of this revision, information was extracted from the medical charts of the 630 patients receiving comprehensive medical care as of 1980 at 6 haemophilia
Lancet. 1988 Mar 5;1(8584):524-5. Unique Identifier : AIDSLINE MED/88142264
Cook CC; Scannell TD; Lipsedge MS; Department of Psychiatry, United Medical School, Guy's Hospital,; London.
A double-blind comparison of clonidine and lofexidine in the management of the opioid withdrawal syndrome encountered several difficulties of a non-scientific nature which eventually forced termination of the trial. There were, for example, problems with research beds, self-discharges, staff attitudes, access to haema
Lauer SA; Fischer J; Jones J; Gartner S; Dutcher J; Hoxie JA; Department of Ophthalmology, Albert Einstein College of; Medicine/Montefiore Medical Center, Bronx, NY 10467.
This is the first report of orbital involvement in systemic adult T-cell leukemia/lymphoma (ATLL). The etiologic agent of ATLL is the human T-cell leukemia virus-I (HTLV-I), the first retrovirus demonstrated to induce cancer in humans. The diagnosis of ATLL is based on characteristic clinicopathologic features in comb
Am J Med Sci. 1988 Feb;295(2):137-9. Unique Identifier : AIDSLINE MED/88147974
Masuda A; Tsushima T; Shizume K; Ohashi K; Tanino S; Sato K; Oshimi K; Mizoguchi H; Kuki H; Yoshida M; Department of Medicine, Tokyo Women's Medical College, Japan.
Adult T-cell leukemia (ATL) is characterized by peripheral lymph node enlargement, hepatosplenomegaly and skin lesions. The association of local mass lesions of other organs with ATL is extremely rare. This report describes a 57-year-old woman with chronic type ATL with associated local tumor masses in the nasal cavit
Takahashi K; Tanaka T; Fujita M; Horiguchi Y; Miyachi Y; Imamura S; Department of Dermatology, Faculty of Medicine, Kyoto, Japan,; University.
A 60-year-old woman suffered from multiple subcutaneous nodules with a self-limited clinical course. High titer of the antibody against the adult T-cell leukemia/lymphoma (ATL)-associated cell antigen was detected and atypical lymphocytes were present in less than 1% of the peripheral leukocytes. Tumor cells were iden
Ann Neurol. 1988;23 Suppl:S113-20. Unique Identifier : AIDSLINE MED/88162135
Roman GC; Department of Neurology, Texas Tech University Health Sciences; Center School of Medicine, Lubbock 79430.
Recent neuroepidemiological studies of endemic tropical spastic paraparesis (TSP) have confirmed the existence of high-prevalence foci in several tropical islands, including Jamaica and Martinique
Ann Neurol. 1988;23 Suppl:S121-6. Unique Identifier : AIDSLINE MED/88162136
Rodgers-Johnson P; Morgan OS; Mora C; Sarin P; Ceroni M; Piccardo P; Garruto RM; Gibbs CJ Jr; Gajdusek DC; Laboratory of Central Nervous System Studies, National Institute; of Neurological and Communicative Disorders and Stroke, Bethesda,; MD 20892.
We report clinical and laboratory investigations of 47 native-born Jamaican patients with endemic tropical spastic paraparesis and of 1 patient with tropical ataxic neuropathy. Mean age at onset was 40 years, with a female-male preponderance (2.7:1). Neurological features of endemic tropical spastic paraparesis are pr
Ann Neurol. 1988;23 Suppl:S13-6. Unique Identifier : AIDSLINE MED/88162138
Rosenblum ML; Levy RM; Bredesen DE; So YT; Wara W; Ziegler JL; Department of Neurosurgery, University of California, San; Francisco 94143.
Primary central nervous system non-Hodgkin s lymphomas are observed in approximately 1.9% of all patients with acquired immunodeficiency syndrome (AIDS). The yearly incidence of AIDS-associated tumors has surpassed the yearly incidence from all other causes and could become as frequent as low-grade astrocytomas by 199
Ann Neurol. 1988;23 Suppl:S143-50. Unique Identifier : AIDSLINE MED/88162141
Usuku K; Sonoda S; Osame M; Yashiki S; Takahashi K; Matsumoto M; Sawada T; Tsuji K; Tara M; Igata A; Third Department of Internal Medicine, Faculty of Medicine,; Kagoshima University, Japan.
HLA haplotypes of 27 patients with human T-lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM) and 12 patients with adult T-cell leukemia/lymphoma (ATLL) were examined by analyzing HLA types of the patients and their family members. Either A11Bw54Cw1DR4DQw3, A24Bw54Cw1DR4DQ-, A24B7Cw7DR1DQw1, or A24Bw52Cw-D
Ann Neurol. 1988;23 Suppl:S151-5. Unique Identifier : AIDSLINE MED/88162142
Johnson RT; Griffin DE; Arregui A; Mora C; Gibbs CJ Jr; Cuba JM; Trelles L; Vaisberg A; Department of Neurology, Johns Hopkins University School of; Medicine, Baltimore, MD 21205.
Three of 6 patients with spastic paraparesis in Lima, Peru , were found to have antibodies to human T-lymphotropic virus type I (HTLV-I). Blood and cerebrospinal fluid antibodies were confirmed by Western blot analysis. Multilobulate
Ann Neurol. 1988;23 Suppl:S161-5. Unique Identifier : AIDSLINE MED/88162144
Arango C; Concha M; Zaninovic V; Corral R; Biojo R; Borrero I; Rodgers-Johnson P; Mora C; Garruto RM; Gibbs CJ Jr; et al; Department of Internal Medicine, Faculty of Health, University of; Valle, Cali, Columbia.
The clinical syndrome earlier designated as paraparesia espastica del Pacifico is an isolated form of tropical spastic paraparesis (TSP) that was reported in 1981 in the southern Pacific lowlands of Columbia in and near Tumaco. The clinical features are similar to those of TSP reported in
Ann Neurol. 1988;23 Suppl:S174-80. Unique Identifier : AIDSLINE MED/88162148
Murphy EL; Blattner WA; Viral Epidemiology Section, National Cancer Institute, Bethesda,; MD 20892.
Human T-lymphotropic virus type I (HTLV-I) has been associated with adult T-cell leukemia/lymphoma (ATL), a malignancy of mature CD4-positive lymphocytes, and with tropical spastic paraparesis (TSP), a demyelinating neurological syndrome. This article describes the clinical and pathological features of ATL and reviews
Ann Neurol. 1988;23 Suppl:S181-4. Unique Identifier : AIDSLINE MED/88162149
Sarin PS; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, MD 20892.
Human lymphotropic retroviruses have been identified as the etiological agents of adult T-cell leukemia and acquired immunodeficiency syndrome (AIDS). Human T-lymphotropic virus type I (HTLV-I) has been linked to the etiology of ATL, and human immunodeficiency virus type I (HIV-1) has been identified as the cause of A
Ann Neurol. 1988;23 Suppl:S188-91. Unique Identifier : AIDSLINE MED/88162151
Ceroni M; Piccardo P; Rodgers-Johnson P; Mora C; Asher DM; Gajdusek DC; Gibbs CJ Jr; Laboratory of Central Nervous System Studies, National Institute; of Neurological and Communicative Disorders and Stroke, Bethesda,; MD 20892.
High titers of antibody to human T-lymphotropic virus type I (HTLV-I) have been reported in the sera and cerebrospinal fluids of patients with tropical spastic paraparesis. By means of agarose isoelectric focusing and selective immunoblotting, we demonstrated oligoclonal bands of immunoglobulin G antibodies to HTLV-I
Ann Neurol. 1988;23 Suppl:S217. Unique Identifier : AIDSLINE MED/88162162
Gibbs CJ Jr; Laboratory of Central Nervous System Studies, National Institute; of Neurological and Communicative Disorders and Stroke, Bethesda,; MD 20892.
Marcus-Sekura CJ; Woerner AM; Klutch M; Quinnan GV Jr; Division of Virology, Office of Biologics Research and Review,; Bethesda, MD 20892.
A segment of the gag gene of the human immunodeficiency virus (HIV) (HTLV-IIIB strain), the virus which causes acquired immunodeficiency syndrome (AIDS), has been cloned into the bacterial expression vector, pCQV2, and mapped to the right-hand portion of the gag gene containing the carboxyl-terminal portion of p24 and
Lee MH; Sano K; Morales FE; Imagawa DT; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance; 90509.
The sensitive overnight reverse transcriptase and the antigen capture enzyme-linked immunosorbent assays were tested for their ability to detect human immunodeficiency virus. The two assays were able to quantitate as few as 75 to 130 virus particles. Thus, both tests offer similar sensitivities for determining the pre
J Immunol. 1988 Feb 15;140(4):1117-22. Unique Identifier : AIDSLINE MED/88140279
Folks TM; Justement J; Kinter A; Schnittman S; Orenstein J; Poli G; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892.
The present study has investigated the effect of PMA, an inducer of monocyte differentiation, on HIV expression in a chronically infected promonocyte clone. After acute HIV infection of U937 cells, clones that constitutively expressed varying levels of HIV were isolated by limiting dilution. One clone (U1) produced lo
Lancet. 1988 Feb 27;1(8583):454-7. Unique Identifier : AIDSLINE MED/88142209
Martinez-A C; Marcos MA; de la Hera A; Marquez C; Alonso JM; Toribio ML; Coutinho A; Centro de Biologia Molecular, C.S.I.C., Universidad Autonoma,; Madrid, Spain.
Immunosuppression in AIDS might be due to the immune response rather than to the pathogenicity of the virus. The basis of the immunosuppression could be molecular mimicries involving viral gp-110, CD4 molecules, antibodies, and CD4-acceptor sites. Whether an individual develops auto-immunosuppressive responses or moun
N Engl J Med. 1988 Mar 10;318(10):589-93. Unique Identifier : AIDSLINE MED/88143002
Kovacs JA; Ng VL; Masur H; Leoung G; Hadley WK; Evans G; Lane HC; Ognibene FP; Shelhamer J; Parrillo JE; et al; Critical Care Medicine Department, National Institute of Allergy; and Infectious Diseases, Bethesda, MD 20892.
With the dramatic increase in the frequency of Pneumocystis carinii pneumonia associated with human immunodeficiency virus infection, there has been a need for more rapid and less invasive diagnostic techniques. Recent studies have shown that examination of induced sputum can establish the diagnosis of P. carinii pneu
Rubinstein A; Bernstein LJ; Charytan M; Krieger BZ; Ziprkowski M; Department of Pediatrics, Albert Einstein College of Medicine,; Bronx, New York 10461.
Five children with positive serology for human immunodeficiency virus (HIV) infection by enzyme-linked immunosorbent assay and Western blot were followed for chronic pulmonary disease. Lung biopsies were performed in all patients, and confirmed the diagnosis of pulmonary lymphoid hyperplasia. All children demonstrated
Goetz DW; Hall SE; Harbison RW; Reid MJ; Department of Medicine, Wilford Hall US Air Force Medical Center,; Lackland Air Force Base, Texas.
A 5-month-old white girl having persistent oral candidiasis was brought to medical attention because of acute respiratory distress, pneumonia, and hypoxia that worsened despite supportive care and antibiotics. Bronchial lavage fluid yielded Pneumocystis carinii. The diagnosis of acquired immunodeficiency syndrome (AID
Kurtzberg J; Friedman HS; Kinney TR; Chaffee S; Stine K; Falletta JM; Weinhold KJ; Department of Pediatrics, Duke University Medical Center, Durham,; North Carolina 27710.
A 17-month-old boy in whom immune-mediated thrombocytopenia (ITP) was the presenting manifestation of infection with human immunodeficiency virus (HIV) is being successfully managed with intermittent high-dose intravenous gamma globulin (IVIG) allowing maintenance of hemostatic platelet counts while avoiding the immun
St. Clair MH; Richards CA; Spector T; Weinhold KJ; Miller WH; Langlois AJ; Furman PA; Department of Virology, Burroughs Wellcome Co., Research Triangle; Park, North Carolina 27709.
Reverse transcriptase was purified from human immunodeficiency virus (HIV). It utilized the artificial primer-template poly(rA)-oligo(dT)12-18 more efficiently than activated calf thymus DNA, poly(rI)-oligo(dC)12-18, poly(rC)-oligo(dG)12-18, or poly(rCm)-oligo(dG)12-18. Maximum activity was observed at pH 7.0 to 7.6 i
Mous J; Heimer EP; Le Grice SF; Central Research Units, F. Hoffmann-La Roche Ltd., Basel,; Switzerland.
Expression of the human immunodeficiency virus type I pol open reading frame in Escherichia coli led to several protease-mediated processing steps of the pol precursor polyprotein. Accumulation of two polypeptides with molecular sizes of 64 and 52 kilodaltons, with which reverse transcriptase activity is associated, w
Proc Natl Acad Sci U S A. 1988 Mar;85(6):1932-6. Unique Identifier : AIDSLINE MED/88158107
Palker TJ; Clark ME; Langlois AJ; Matthews TJ; Weinhold KJ; Randall RR; Bolognesi DP; Haynes BF; Department of Medicine, Duke University Medical Center, Durham,; NC 27710.
A synthetic peptide (SP-10-IIIB) with an amino acid sequence [Cys-Thr-Arg-Pro-Asn-Asn-Asn-Thr-Arg-Lys-Ser-Ile-Arg-Ile-Gln-Arg-- Gly-Pro -Pro-Gly-(Tyr); amino acids 303-321] from the human immunodeficiency virus (HIV) isolate human T-cell lymphotropic virus type III (HTLV-III) HTLV-IIIB envelope glycoprotein gp120 was
Ann Neurol. 1988;23 Suppl:S166-70. Unique Identifier : AIDSLINE MED/88162145
Koprowski H; DeFreitas E; Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.
Three entities--multiple sclerosis, tropical spastic paraparesis, and human T-lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM)--may represent manifestations of the same disease, with HTLV-I-like virus playing a role in their etiology. Tests for the presence of antibodies reacting with either HTLV-I-like
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