Management of human immunodeficiency virus-induced thrombocytopenia in hemophilia. NLM AIDSLINE Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

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Management of human immunodeficiency virus-induced thrombocytopenia in hemophilia.

Aust N Z J Med. 1987 Dec;17(6):581-4. Unique Identifier : AIDSLINE MED/88192568
Kellner SV; McGrath KM; Street AM; Haematology Department, Alfred Hospital, Vic.

Abstract: Three patients with severe hemophilia and Human Immunodeficiency Virus (HIV) infection seropositive for virus antibody, presented with thrombocytopenia. Treatment with prednisolone, danazol (in one patient) and intravenous gammaglobulin, produced only transient responses. In one case, danazol treatment resulted in a rash, fever and a further fall in platelet count. The use of combined intravenous gammaglobulin and splenectomy successfully resulted in sustained elevation of platelet counts in all three patients. These counts have remained elevated at eight months, ten months and 17 months after operation.
Keywords: Adult Blood Transfusion/ADVERSE EFFECTS Case Report Christmas Disease/COMPLICATIONS Hemophilia/*COMPLICATIONS Human HIV Seropositivity/*COMPLICATIONS *Immunization, Passive Male Platelet Count *Splenectomy Thrombocytopenia/ETIOLOGY/*THERAPY JOURNAL ARTICLE

KWDadultbloodtransfusion/adverseeffectscasereportchristmasdisease/complicationshemophilia/KWDcomplicationshumanhivseropositivity/KWDcomplicationsKWDimmunization,passivemaleplateletcountKWDsplenectomythrombocytopenia/etiology/KWDtherapyjournalarticle
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Copyright © 1988 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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