Phillips M; Vazquez AJ; Department of Medicine, Chicago Medical School, IL 60064.
We report three cases in which medical students who participated in clinical studies as normal volunteers were discovered, during the course of the research, to have potentially serious abnormalities. Their previously unsuspected conditions included chronic persistent hepatitis, a lesion in the cerebral cortex, and se
EMBO J. 1987 Dec 20;6(13):4067-71. Unique Identifier : AIDSLINE MED/88166651
Dinter H; Chiu R; Imagawa M; Karin M; Jones KA; Molecular Biology and Virology Laboratory, Salk Institute for; Biological Studies, La Jolla, CA 92037.
The transition from persistent to lytic infection by the human immunodeficiency virus, HIV, is marked by a burst of viral replication and gene expression that occurs when infected cells are stimulated by physiological inducers or tumor promoters like 12-O-tetradecanoyl phorbol acetate (TPA). We report here that the HI
Arbesser C; Bashiribod H; Sixl W; Institute of Hygiene of the University of Graz, Austria.
544 human blood samples from 2 hospitals in Teheran, Iran , were tested for HIV-virus antibodies. 35 samples were positive in 2 different ELISA tests; however, these samples were negative in the Western Blot test. Further studies are underway.
Pediatr Med Chir. 1987 Nov-Dec;9(6):743-4. Unique Identifier : AIDSLINE MED/88176557
Azzini M; Maccabruni A; Marcellini M; Michelone G; Dei Cas A; Istituto di Clinica delle Malattie Infettive, IRCCS Policlinico; S. Matteo, Universita di Pavia, Italia.
Two cases of post-transfusional AIDS in two premature babies who received blood of the same seropositive donor, are reported. The risk of the susceptibility to HIV infection of these patients, in relation to the immaturity of immune system and to the transfusional treatment often necessary in premature newborns, is st
Rev Med Interne. 1987 Nov-Dec;8(5):463-5. Unique Identifier : AIDSLINE MED/88177625
Henrion R; Sereni D; Maternite Port-Royal, Paris.
The incidence of HIV infection in women is increasing steadily. It has been estimated that between 30,000 and 40,000 French women in child-bearing age are seropositive for HIV. The risk of a seropositive woman transmitting the virus to her child is 40-50 p. 100, and the child will often develop AIDS during the first t
Rev Med Interne. 1987 Nov-Dec;8(5):481-4. Unique Identifier : AIDSLINE MED/88177629
Jaubert D; Hauteville D; Service de medecine II, hopital d'Instruction des Armees; Sainte-Anne, Toulon Naval.
The authors have studied the clinical aspects and mechanism of the thrombocytopenia observed in heroin addicts in the light of recently published data. This relatively frequent complication of intravenous drug addiction must be related to the immunological disturbances caused by carriage of the HIV virus. The evolutiv
Trans R Soc Trop Med Hyg. 1987;81(4):595. Unique Identifier : AIDSLINE MED/88178968
Antunes F; Carvalho C; Tavares L; Botas J; Forte M; del Rio AM; Dutschmann L; Costa A; Abranches P; Pereira CS; et al; Departamento de Doencas Infecciosas e Parasitarias, Faculdade; de Medicina de Lisboa, Hospital de Santa Maria, Lisbon, Portugal.
The penetration and spread of infection caused by human immunodeficiency virus has been detected in the USSR. The infection was brought by a homosexual who got infected in East Africa in 1982. In the USSR he infected 5 out of his 22 sexual partners who, in their turn, transferred the infection to 3 women in heterosexu
A 34-year-old heterosexual intravenous drug abuser presented with a paranoid psychosis and was subsequently found to have the Acquired Immune Deficiency Syndrome (AIDS). The patient died 14 days later of generalised septicaemia. The case is reported and the aetiology and pathogenesis of the organic psychosis are discu
Postgrad Med J. 1987 Oct;63(744):877-9. Unique Identifier : AIDSLINE MED/88189972
Rademaker M; Thomas RH; Provost TG; McEvoy M; Grint PC; Heath R; Kirby JD; Department of Dermatology, St Bartholomew's Hospital, West; Smithfield, London, UK.
We report two cases of acquired immune deficiency syndrome (AIDS), apparently without the usual exposure factors, in whom a temporal association was detected after detailed epidemiological investigation. The index case, a 45 year old housewife, had provided terminal home-nursing care for a 33 year old African man, who
Aust N Z J Med. 1987 Dec;17(6):581-4. Unique Identifier : AIDSLINE MED/88192568
Kellner SV; McGrath KM; Street AM; Haematology Department, Alfred Hospital, Vic.
Three patients with severe hemophilia and Human Immunodeficiency Virus (HIV) infection seropositive for virus antibody, presented with thrombocytopenia. Treatment with prednisolone, danazol (in one patient) and intravenous gammaglobulin, produced only transient responses. In one case, danazol treatment resulted in a r
This survey suggests that HIV infection in immunocompromised hosts is characterized by a high attack rate, short incubation time to clinical sequelae, and WB and RIP seropositivity which may precede evidence of antibodies by ELISA by weeks or months. The functional properties of patients serum antibodies, such as neu
Heisig V; Benter T; Josephs SF; Sadaie MR; Okamoto T; Gallo RC; Wong-Staal F; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, Maryland 20892.
The location of cis-acting regulatory sequences within the long terminal repeat (LTR) of the human T-cell lymphotropic virus type III was determined by eukaryotic cell transfection and chloramphenicol acetyltransferase (CAT) assay or in vitro cell-free transcription. A 160 base pair (bp) region of the LTR at position
The data on the morphogenesis, biology and genetics of human immunodeficiency virus, as well as on the epidemiology of AIDS, are presented. Different assay systems developed in the USSR for the diagnosis of AIDS are described. The prospects for improving diagnostic techniques with the use of gene engineering are consi
Prusek W; Jankowski A; Radomska G; Wieczorek E; Podwysocka M; Department of Pediatrics, Regional Hospital, Wroclaw.
Selected immunologic parameters and effectivity of immunotherapy was evaluated in 117 children (12-month-10-year-1-old) suffering from recurrent respiratory tract infections. All the children displayed a profound depression of T lymphocytes number, which resemble the situation seen in AIDS patients. An increase of ser
Aust N Z J Med. 1987 Dec;17(6):551-6. Unique Identifier : AIDSLINE MED/88192563
Gibson PG; Bryant DH; Harkness J; Munro VF; Penny R; Cooper DA; Department of Thoracic Medicine, St. Vincent's Hospital, NSW.
Between 1983 and 1985, 71 patients with the acquired immunodeficiency syndrome (AIDS) were evaluated. Pulmonary manifestations were present in 42 patients (59%). Pneumocystis carinii pneumonia (PCP) was the most common pulmonary manifestation, present in 32 patients (45%). Other pulmonary findings were
Cancer Invest. 1987;5(6):615-25. Unique Identifier : AIDSLINE MED/88164484
Blumberg N; Heal JM; Blood Bank, Strong Memorial Hospital, Rochester, New York.
Evidence regarding the association of blood transfusions with recurrence of solid tumors is largely conflicting. This is perhaps not surprising given the retrospective nature of the studies, the complexity of the disease and its treatment, and variations in local transfusion practices. Nonetheless, data demonstrating
Woolf GM; Townsend M; Guyatt G; McMaster University Medical Center, Department of Medicine,; Hamilton Ontario, Canada.
We describe a randomized, double-blind, placebo-controlled, crossover trial with spiramycin in a single patient with acquired immune deficiency syndrome (AIDS) and a severe secretory diarrhea caused by cryptosporidium. Spiramycin, a potentially harmful antibiotic, had no clinical or microbiological effect in this pati
Arbesser C; Mose JR; Sixl W; Institute of Hygiene of the University of Graz, Austria.
1614 blood samples from men and women in the Upper Nile region, Melut district (southern Sudan ) were examined for HIV-antibodies. 109 samples were positive twice in the ELISA test, and 18 (1.1%) were confirmed by the IFT and Western Blot test.
Arbesser C; Mose JR; Sixl W; Linck G; Institute of Hygiene of the University of Graz, Austria.
22 of 182 sera samples from Nicaragua , 6 of 111 samples from Columbia, and 25 of 388 samples from El Salvador were positive in the ELISA test. 37 of the 53 positive sera samples were positive again in a further ELISA test, and 1 of them w
Marth E; Stunzner D; Hengster P; Sixl WD; Institute of Hygiene of the University of Graz, Austria.
240 serum samples originating from various AIDS risk groups were tested for HIV-antibodies comparing an immunofluorescence test with the Western Blot and ELISA methods. In 95% of cases the results of the Western Blot and the immunofluorescence test were in accordance. In 12 samples the immunofluorescence test yielded
Fenton TW; Hollymoor Hospital, Birmingham, West Midlands.
The background to HIV infection, its mode of transmission, and its neurological and psychiatric complications are described. The management of AIDS-related psychiatric disorder and problems encountered among staff involved in the management of patients suffering from AIDS are considered. There is a need for appropriat
Recognition of Kaposi s sarcoma and its prevalence in the lower extremities is reviewed in light of a recent association with the acquired immunodeficiency syndrome (AIDS).
Dalgleish AG; Malkovsky M; MRC Clinical Research Centre, Middlesex, UK.
A wide variety of surgical gloves are presently available. Seven different types of gloves were investigated for the ability to prevent transmission of the human immunodeficiency virus (HIV), the causative agent of AIDS. Six types of gloves withstood severe compression tests and also exhibited direct antiviral propert
Can J Ophthalmol. 1988 Feb;23(1):5-7. Unique Identifier : AIDSLINE MED/88164618
Govig B; Jackson WB; Gilmore N; Department of Ophthalmology, Royal Victoria Hospital, McGill; University, Montreal, PQ.
The risk of acquiring HIV infection during an ophthalmologic examination appears to be small but theoretically present. Since it is not always possible to ascertain the presence of HIV infection and because of the grave consequences of infection, all patients must be considered potential carriers. Appropriate preventi
Fournier AM; Dickinson GM; Erdfrocht IR; Cleary T; Fischl MA; Division of General Medicine and Infectious Disease, University; of Miami School of Medicine.
Thirty-six patients with AIDS and culture-proven nontuberculous mycobacteriosis were compared to 20 patients with acquired immunodeficiency syndrome (AIDS) and tuberculosis with regard to clinical signs, symptoms, and diagnostic methods. Patients with nontuberculous mycobacteriosis were more often younger and homosexu
Dietl JA; von Finck M; Univ.-Frauenklinik Tubingen.
Public concern about the safety of transfusion was aroused by the discovery that the acquired immuno deficiency syndrome (AIDS) can be transmitted by blood transfusion. Patients who require transfusion are now apprehensive to the point of seeking alternatives or even refusing to receive blood. Autologous transfusion o
Anderson DW; Virmani R; Reilly JM; O'Leary T; Cunnion RE; Robinowitz M; Macher AM; Punja U; Villaflor ST; Parrillo JE; et al; Center for Biologics Research and Review, U.S. Food and Drug; Administration, Bethesda, Maryland.
The prevalence of myocarditis was retrospectively evaluated in 71 consecutive necropsy patients who died from acquired immunodeficiency syndrome (AIDS) between 1982 and 1986. Myocarditis was found in 37 cases (52%). Biventricular dilation at necropsy was present in seven cases (10%) and was accompanied by myocarditis
O'Rourke K; Perryman LE; McGuire TC; Department of Veterinary Microbiology and Pathology, Washington; State University, Pullman 99163.
Equine infectious anaemia virus is related by genome sequence homology to human immunodeficiency virus, caprine arthritis-encephalitis virus and visna virus. Failure of the host to mount a strong neutralizing response detectable in vitro or to eliminate persistent infection in vivo characterizes lentivirus infections
Lima G; Traina C; Coordinatore Sanitario U.S.L. 58, Palermo.
A case of ARC/LAS syndrome in a student nurse accidentally pricked by an infected needle is reported. This case-report is published to encourage the recognition of hospital staff.
De Gruttola V; Mayer KH; Channing Laboratory, Harvard Medical School, Boston,; Massachusetts 02115.
Epidemiologic investigation of the AIDS epidemic among heterosexuals has consisted chiefly of studies of partners of individuals infected with the human immunodeficiency virus (HIV) and population surveillance. Heterosexual partners of infected individuals appear to be at high risk of infection, but only a small propo
Hatziandreu E; Graham JD; Stoto MA; Department of Epidemiology, Harvard School of Public Health,; Boston, Massachusetts 02115.
One of the critical policy questions raised by the AIDS epidemic is the proper size of the United States federal government s commitment to AIDS-related research. The extent of the federal government s investment in AIDS-related research in relation to research investments in cancer, c
Rapoport AP; Rowe JM; McMican A; Department of Medicine, University of Rochester Medical Center,; New York 14642.
Increasing numbers of patients are being seen with the acquired immune deficiency syndrome (AIDS). An abnormal serology with a positive direct antiglobulin test has been observed in these patients and is usually not thought to contribute to significant clinical morbidity. We describe a patient with AIDS who presented
Horsburgh CR Jr; Holmberg SD; AIDS Program, Centers for Disease Control, Atlanta, Georgia.
We reviewed published reports of infection with human immunodeficiency virus type 2 (HIV-2) to provide a picture of its geographic distribution, pathogenicity, modes of transmission, and risk to the blood supply. Since the first reports in 1986, 627 HIV-2-seropositive persons have been reported; 604 of these were in n
Langley D; Spier RE; Department of Microbiology, University of Surrey, Guildford, UK.
The need to control the spread of human immunodeficiency viruses (HIVs) is unquestioned. Options for interference in the replicative cycle of HIV have been reviewed by Mitsuya and Broder. It is possible to propose antiviral agents which would be active at each stage of the cycle, but early experience suggests that hig
Helweg-Larsen S; Jakobsen J; Boesen F; Arlien-Soborg P; Brun B; Smith T; Ulrich K; Orskov B; Gyldensted C; Permin H; et al; National Hospital, Copenhagen, Denmark.
In a cross-sectional population study of Danish patients with AIDS 16 of 23 had clinical signs of neurological disease with muscle weakness or ataxia of the lower limbs as the dominant manifestation. Tibial and median nerve conduction was mildly slowed in a few patients and 15 had widening of cerebral ventricles at CT
Am J Pathol. 1988 Apr;131(1):38-47. Unique Identifier : AIDSLINE MED/88181136
Scoazec JY; Marche C; Girard PM; Houtmann J; Durand-Schneider AM; Saimot AG; Benhamou JP; Feldmann G; Laboratoire d'Histologie et de Biologie Cellulaire, Hopital; Bichat, Paris, France.
The description of hepatic sinusoidal lesions in a significant number of acquired immunodeficiency syndrome (AIDS) patients prompted the authors to undertake an ultrastructural study of the sinusoidal barrier abnormalities during human immunodeficiency virus (HIV) infection, in order to compare these lesions with thos
Am J Public Health. 1988 May;78(5):576-7. Unique Identifier : AIDSLINE MED/88181312
Seage GR 3d; Barry MA; Landers S; Silvia AM; Lamb GA; Department of Community Health, Boston Department of Health and; Hospitals, MA.
Of 978 respondents to an anonymous questionnaire targeted to reach homosexuals in Boston during October 1984, 88 (9 per cent) reported recent blood donation. When compared to non-recent donors, high-risk respondents who were recent blood donors were younger, less open about their sexual preference, and more likely to
Deam R; Kimberley AP; Anderson M; Soni N; Department of Anaesthetics, Westminster Hospital, London.
The admission of patients with acquired immune deficiency syndrome (AIDS) to intensive care units in the United Kingdom was surveyed in January 1986. Ninety-three intensive care units completed the questionnaire. Thirty-two patients had been admitted to 12 units up to that time. Twenty
MacMillan RM; Rees MR; Hahnemann University School of Medicine, Philadelphia,; Pennsylvania.
Twenty-seven patients had left ventricular ejection fraction (LVEF) measured by catheterization, single-plane angiography, and ultrafast computed tomography (cine CT). Twelve patients (mean age sixty-two years) had LVEF measured by use of the cine CT long-axis view LAV), and 15 patients (mean age fifty-eight years) ha
An Esp Pediatr. 1988 Feb;28(2):89-92. Unique Identifier : AIDSLINE MED/88181879
Espanol T; Bofill A; de Buen L; Calico I; Sentis M; Moraga F; Bertran JM; Servicio de Immunologia, Hospital Infantil, Barcelona.
Acquired immunodeficiency syndrome (AIDS) in infants has different clinical and immunological characteristics from adult AIDS because of immunological immaturity of the fetus and newborn when infection is produced. Differential diagnosis with primary immunodeficiency diseases, mainly with severe combined immunodeficie
Tenholder MF; Moser RJ 3d; Tellis CJ; Pulmonary Disease Service, Walter Reed Army Medical Center,; Washington, DC 20307-5001.
A normal host can be colonized by mycobacteria other than tuberculosis (MOTT), resulting in bronchoscopic isolates of no clinical significance. In the acquired immunodeficiency syndrome (AIDS), Mycobacterium avium-intracellulare, Mycobacterium kansasii, and Mycobacterium xenopi have caused widely disseminated infectio
A full-length molecular clone of human immunodeficiency virus (HIV) proviral DNA was transferred to human rhabdomyosarcoma (RD) cells by gene transfer method. RD cells released infectious virus within 12 hours after transfection and the viral particles present in the culture medium could be quantitated by monitoring r
Capobianchi MR; De Marco F; Di Marco P; Dianzani F; Institute of Virology, University of Rome, Italy.
We compared the properties of interferon (IFN) induced in peripheral blood mononuclear cells (PBMC) by free infectious HIV to that induced by HIV-infected cells fixed with glutaraldehyde. While the IFN induced by HIV was a conventional IFN alpha, the IFN induced by HIV-infected cells, although sharing with IFN alpha b
Sanchez MA; Ames ED; Erhardt K; Auer GU; Department of Pathology, Englewood Hospital, New Jersey 07631.
While Kaposi s sarcoma in patients with the acquired immune deficiency syndrome (AIDS) may present as a multicentric disease with progressive organ involvement, the classic form of Kaposi s sarcoma is an indolent tumor seldom affecting extracutaneous areas and almost never responsible for the patient s demise. An atte
Minamoto GY; Scheinberg DA; Dietz K; Gold JW; Chein N; Gee T; Reich LM; Hoffer J; Mayer K; Armstrong D; et al; Department of Medicine, Memorial Sloan-Kettering Cancer Center,; New York 10021.
Eighteen human immunodeficiency virus (HIV)-seropositive patients were found among 211 previously treated adult patients with a variety of leukemias who had been multiply transfused before April 1985. Patients known to be homosexual or intravenous drug users were excluded from this study. The spouse of one HIV-seropos
Messiah A; Mary JY; Brunet JB; Rozenbaum W; Gentilini M; Valleron AJ; Bureau des maladies transmissibles, Ministere des Affaires; Sociales et de l'Emploi, Paris, France.
To identify risk factors for A.I.D.S. among homosexual men in France , a high-risk group in a moderate-incidence area, we undertook a case-control study in Paris and its suburbs. Fifty-three cases were compared to 99 controls from a venereal disease clinic and 79 controls from the s
Balachandran R; Thampatty P; Rinaldo C; Gupta P; Department of Infectious Diseases and Microbiology, Graduate; School of Public Health, University of Pittsburgh, Pennsylvania; 15261.
The possibility was investigated of using frozen stocks of phytohemagglutinin (PHA)-stimulated normal human peripheral blood lymphocytes (PBL) in cocultivation with human immunodeficiency virus (HIV)-infected lymphocytes for the isolation of HIV. Fresh and cryopreserved PBL from eight healthy volunteers were compared
Sirianni MC; Soddu S; Malorni W; Arancia G; Aiuti F; Soddus S/[corrected to Soddu S]; Department of Clinical Immunology, University of Rome, Italy.
Previous studies have demonstrated the importance of some cytoskeleton components in killing mechanisms. In fact, a microtubule and microfilament (MF) rearrangement in the lytic sequence of CTL and NK cells has been observed. In particular, MF seem to be related to the binding phase, because MF inhibitors suppress the
Landefeld CS; Chren MM; Shega J; Speroff T; McGuire E; Department of Medicine, Case Western Reserve University,; Cleveland, Ohio.
Five hundred ninety students receiving primary care in a university health service were surveyed anonymously in 1985-86 to study their self-reported sexual behavior and knowledge and attitudes about acquired immunodeficiency syndrome (AIDS). Most students (75%) were heterosexual; 3% were homosexual, 3% bisexual, and 1
Cunha BA; Strampfer MJ; Infectious Disease Division, Winthrop-University Hospital,; Mineola, NY 11501.
As more types of human immunodeficiency virus (HIV) are recognized and as the incidence of acquired immunodeficiency syndrome (AIDS) increases, more and more manifestations of HIV infection will be recognized. Dermatologic conditions often provide a means of making the presumptive diagnosis. Months or years of asympto
Proc Natl Acad Sci U S A. 1988 Apr;85(8):2815-9. Unique Identifier : AIDSLINE MED/88190159
Cheng-Mayer C; Homsy J; Evans LA; Levy JA; Department of Medicine, University of California, San Francisco; 94143.
The human immunodeficiency virus (HIV) type 1 displays a high degree of genetic variation, especially in the glycoprotein (gp120) domain of the envelope gene. To determine whether this genomic heterogeneity leads to the expression of independent HIV subtypes, 12 sera from HIV type 1 antibody-positive individuals were
Stat Med. 1988 Mar;7(3):395-401. Unique Identifier : AIDSLINE MED/88190627
Lui KJ; Peterman TA; Lawrence DN; Allen JR; Division of Viral Diseases, Center for Infectious Diseases,; Atlanta, GA 30333.
Traditional statistics, such as the average, currently provide a misleading statistical description of the incubation periods of paediatric transfusion-associated acquired immunodeficiency syndrome (TA-AIDS). Two types of length-biased sampling, left censoring and right censoring, occur in the 37 cases diagnosed befor
Sex Transm Dis. 1988 Jan-Mar;15(1):1-4. Unique Identifier : AIDSLINE MED/88190984
Hofmann B; Kryger P; Pedersen NS; Nielsen JO; Oehlenschlager J; Koerner EA; van den Berg T; Sprechler HH; Nielsen CM; Gerstoft J; et al; Department of Infectious Diseases, University Hospital,; Rigshospitalet, Copenhagen, Denmark.
Sera from 260 men from Denmark and elsewhere attending two Copenhagen sauna clubs for homosexual men during nine months of 1982-1983 were investigated for markers for syphilis, hepatitis A and B, and human immunodeficiency virus (HI
Ann Intern Med. 1988 May;108(5):744-53. Unique Identifier : AIDSLINE MED/88192144
Knowles DM; Chamulak GA; Subar M; Burke JS; Dugan M; Wernz J; Slywotzky C; Pelicci G; Dalla-Favera R; Raphael B; Department of Pathology, New York University Medical Center, New; York.
We identified 105 patients with lymphoid neoplasia associated with the acquired immunodeficiency syndrome (AIDS) at the New York University Medical Center from 1981 through 1986: 89 had non-Hodgkin lymphoma; 13, Hodgkin disease; and 3, chronic lymphocytic leukemia. Immunophenotypic and antigen receptor gene rearrangem
Gonzales MF; Olney RK; So YT; Greco CM; McQuinn BA; Miller RG; DeArmond SJ; Department of Pathology, University of California, San Francisco; 94143.
An unusual myopathy characterized by selective loss of thick filaments and widespread formation of rod bodies is described in two men, both seropositive for human immunodeficiency virus. We were unable to find any previous reports documenting this combination of morphological abnormalities, which we believe may be rel
Otu AA; Department of Surgery, College of Medical Sciences, University of; Calabar, Nigeria.
The present study has investigated whether Kaposi s sarcoma (KS) in Nigeria is associated with infection with the AIDS virus variously called human T-cell lymphotropic virus type III (HTLV-III), lymphadenopathy/AIDS virus (LAV), and AIDS-associated retrovirus (ARV). Serum samples
Mayo Clin Proc. 1988 Apr;63(4):373-80. Unique Identifier : AIDSLINE MED/88173695
Steckelberg JM; Cockerill FR 3d; Division of Infectious Diseases and Internal Medicine, Mayo; Clinic Jacksonville, FL 32224.
Familiarity with available serologic tests for antibodies to human immunodeficiency virus (HIV) has become increasingly important in a wide variety of clinical settings. Enzyme-linked immunosorbent assay (ELISA) commercial kits are most often used as Enzyme-linked immunosorbent assay (ELISA) commercial kits are most o
Watson-Williams EJ; Yee JL; Carlson JR; Mertens SC; Holland P; Sinor L; Plapp FV; Department of Internal Medicine, University of California, Davis.
In technically developed countries in which acquired immunodeficiency syndrome is a risk to the recipients of blood or tissue, it is mandatory to screen the donor for evidence of HIV (human immunodeficiency virus) infection. Current tests, based on enzyme-linked immunoassay, are time-consuming and expensive and as suc
Wilders-Truschnig M; Muntean W; Zenz W; Vadon M; Beaufort F; Teubl I; Department of Surgery, Karl-Franzens-University, Graz, Austria.
Sera collected from 28 haemophiliacs during the 2 years from 1985 to 1987 were examined for the presence of human immunodeficiency virus (HIV-1) antigen by two different methods using commercially available test kits. Of 28 patients, 18 had been positive for HIV antibody since at least 1985 and their HIV infection by
Cancer Genet Cytogenet. 1988 May;32(1):67-74. Unique Identifier : AIDSLINE MED/88184542
Bernheim A; Berger R; Laboratoire de Cytogenetique, Unite INSERM U301, Hopital St.; Louis, Paris, France.
The frequency of Burkitt lymphoma-leukemia (BL) is high in patients with acquired immunodeficiency syndrome (AIDS). We describe four such cases, three with a translocation t(8;14)(q24;q32) and one with a t(8;22)(q24;q11). No Epstein-Barr virus genome was found in the tumorous cells of this patient. Including these cas
Gioannini P; Sinicco A; Cariti G; Lucchini A; Paggi G; Giachino O; Istituto di Malattie Infettive-Universita di Torino.
We report here the history of the first case of occupationally acquired HIV infection in Italy . Results of serological investigations sequentially performed allow the investigators to outline the natural history of the infection in this case.
Schulte C; Meurer M; Froschl M; Dermatologische Klinik und Poliklinik,; Ludwig-Maximilians-Universitat Munchen.
A total of 219 sera from HIV-infected patients were tested by a competitive immunoassay for the presence of antibodies to env and core protein. Whereas antibodies to the HIV envelope protein (gp41) were detected in all patients, only 84% of the patients with latent infection, 73% of the patients with LAS and 48% of th
Amadori A; De Rossi A; Gallo P; Tavolato B; Chieco-Bianchi L; Institute of Oncology, University of Padova, Italy.
Cerebrospinal fluid lymphocytes from six human immunodeficiency virus (HIV)-infected and three seronegative patients were studied for in vitro synthesis of HIV-specific antibody by means of Western blot analysis of lymphocyte culture supernatants. All the HIV-positive subjects showed in vitro production of HIV-specifi
Zagury D; Bernard J; Cheynier R; Desportes I; Leonard R; Fouchard M; Reveil B; Ittele D; Lurhuma Z; Mbayo K; et al; Institut Jean Godinot, Universite P. et M. Curie, Paris, France.
The first experimental immunization of humans against the AIDS retrovirus, HIV-1, was started in a series of HIV seronegative, healthy volunteers in November 1986. For the primary vaccination recombinant vaccinia virus (V25) expressing the complete gp160 env protein of the HTLV-IIIB strain of HIV-1 was introduced by s
Andrieu JM; Even P; Venet A; Tourani JM; Stern M; Lowenstein W; Audroin C; Eme D; Masson D; Sors H; et al; Laennec HIV Study Group, Laennec Hospital, University of Paris V,; France.
Cyclosporin (7.5 mg/kg daily) was given to 8 AIDS patients for 17-66 days and to 25 HIV-seropositive non-AIDS patients, 15 with stage II (T4 cells/microliter greater than or equal to 300, less than 600) and 10 with stage III (T4/microliter less than 300), for 3-6 months with the hypothesis that the drug could inhibit
Bloom JW; Kaltenborn WT; Quan SF; Department of Internal Medicine, University of Arizona College of; Medicine, Tucson.
In order to study risk factors associated with snoring in a general adult population, 2,187 subjects in the Tucson Epidemiologic Study of Obstructive Airways Disease were surveyed to determine the prevalence of snoring. Major independent risk factors for snoring were male gender, age between 40 and 64 years, obesity,
Immunol Lett. 1988 Jan;17(1):53-7. Unique Identifier : AIDSLINE MED/88168727
Chollet-Martin S; Pialoux G; Gougerot-Pocidalo MA; INSERM U. 294, C.H.U. Xavier Bichat, Paris, France.
CD1 monoclonal antibodies were assayed on peripheral blood mononuclear leukocytes (PBML) of type 1 human immunodeficiency virus (HIV1)-infected patients using immunogold technique. Using IOT6 monoclonal antibody, a significant increase of the CD1 positive cells per microliter of blood was found in acquired immunodefic
Meredith T; Acierno LJ; College of Health, University of Central Florida, Orlando.
Acquired immunodeficiency syndrome (AIDS) is becoming an increasingly important public health problem. This article concerns the pulmonary complications of AIDS, both infectious and neoplastic. After a brief historical introduction, the pathophysiologic mechanisms are presented, followed by a description of the clinic
Gardener TD; Flanagan P; Dryden MS; Costello C; Shanson DC; Gazzard BG; Department of Medicine, St Stephen's Hospital, London, U.K.
During a period of 14 months in 1985 and 1986, infection with Mycobacterium avium-intracellulare (MAI) complex was diagnosed in 10 of 76 patients with Human Immunodeficiency Virus (HIV)-associated infection. In eight of the 10 patients, the infection was disseminated. All eight patients were anaemic. A bone marrow asp
Karpatkin S; Nardi MA; Department of Medicine, New York University Medical Center, NY; 10016.
The immunologic platelet profile of 29 patients with hemophilia who had received multiple transfusions (14 had thrombocytopenia) was compared with profiles of 15 patients with classic autoimmune thrombocytopenia. Thrombocytopenic hemophiliacs who were seropositive for the human immunodeficiency virus (13 out of 14) ha
Balzarini J; Baba M; Pauwels R; Herdewijn P; Wood SG; Robins MJ; de Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
Several sugar-modified 2,6-diaminopurine and guanine 2 ,3 -dideoxyribosides were synthesized and evaluated in vitro for their ability to inhibit the cytopathic effect and replication of human immunodeficiency virus (HIV), the causative agent of acquired immunodeficiency syndrome (AIDS). 3 -Azido-2,6-diaminopurine-2 ,3
Am J Hematol. 1988 Jan;27(1):7-12. Unique Identifier : AIDSLINE MED/88180982
Aronson DL; George Washington University Medical Center, DC 20037.
Death data on 949 hemophiliacs for the years 1968-1979 have been analyzed. The median age at death has increased from 33 to 55 years. There was no evidence of new diseases caused by the more intensive therapy during this time interval. The leading infectious disease was hepatitis, accounting for eight deaths. Only one
Zaman MK; White DA; Department of Medicine, Memorial Sloan-Kettering Cancer Center,; New York, New York.
The level of serum lactate dehydrogenase (LDH) has been reported to be useful as a marker of Pneumocystis carinii pneumonia (PCP) in patients infected with the human immunodeficiency virus (HIV). In this study, we evaluated the clinical role of measurements of LDH in determining diagnosis and prognosis in 84 patients
Tindall B; Barker S; Donovan B; Barnes T; Roberts J; Kronenberg C; Gold J; Penny R; Cooper D; Centre of Immunology, St Vincent's Hospital, Sydney, Australia.
The clinical and serologic features and immune status of 39 homosexual men who had seroconversion to human immunodeficiency virus positivity were compared with 26 homosexual men who remained seronegative during a six-month period. An acute clinical illness occurred in 92.3% of seroconverted subjects and 40% of control
Pauwels R; Baba M; Balzarini J; Herdewijn P; Desmyter J; Robins MJ; Zou RM; Madej D; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
Several 2 ,3 -dideoxyadenosine analogues with modifications in either the ribose or purine moiety were evaluated for their inhibitory effects on the replication of human immunodeficiency virus (HIV) in MT-4 cell cultures. The 2 ,3 -dideoxyriboside of 2,6-diaminopurine (ddDAPR) inhibited HIV antigen expression and HIV-
Beard J; Savidge GF; Division of Haematology, United Medical and Dental Schools, St; Thomas' Hospital, London.
Four patients with severe haemophilia A and one patient with severe Christmas disease developed severe immune thrombocytopenia (platelet count less than 20 x 10(9)/l). All five patients were HIV-antibody positive and one was HIV-antigen positive. Four patients were treated initially with prednisolone, but with only a
Haertle T; Carrera CJ; Wasson DB; Sowers LC; Richman DD; Carson DA; Department of Basic and Clinical Research, Research Institute of; Scripps Clinic, La Jolla, California 92037.
Both 2 ,3 -dideoxyadenosine and 2 ,3 -dideoxyinosine have been shown (Mitsuya, H., and Broder, S. (1987) Nature 325, 773-778) to have in vitro activity against the human immunodeficiency virus-1 (HIV). However, these dideoxynucleosides may be catabolized by human T cells, even when adenosine deaminase is inhibited by
Gendelman HE; Orenstein JM; Martin MA; Ferrua C; Mitra R; Phipps T; Wahl LA; Lane HC; Fauci AS; Burke DS; et al; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland 20892.
Monocytes were maintained in tissue culture for greater than 3 mo in media supplemented with rCSF-1. These cultures provided susceptible target cells for isolation and propagation of virus from PBMC of HIV-infected patients. HIV isolated into monocytes readily infected other rCSF-1-treated monocytes but only inefficie
Bisceglia M; Amini M; Bosman C; Anatomic Pathology Service, Casa Sollievo Della Sofferenza; Hospital, S. Giovanni Rotondo, Italy.
A case of primary Kaposi s sarcoma of the lymph node (single node involvement) is reported on here. It occurred in a white, Italian boy 10 years of age. An extensive review of the literature showed that this was only the second childhood case of the disease among non-acquired immune deficiency syndrome (AIDS)-related
Emerg Med Clin North Am. 1988 May;6(2):317-40. Unique Identifier : AIDSLINE MED/88166578
Hedges JR; Kobernick MS; Department of Emergency Medicine, University of Cincinnati; College of Medicine, Ohio.
Detailed review of the literature for chest discomfort evaluation in the Emergency Department leaves the clinician without a precise guideline as to whom to admit or send home. It is clear that the seasoned physician s instinct (the sum total of the history, physician examination, and ancillary laboratory tests) is as
Blundell T; Carney D; Gardner S; Hayes F; Howlin B; Hubbard T; Overington J; Singh DA; Sibanda BL; Sutcliffe M; Department of Crystallography, Birkbeck College, University of; London.
A systematic technique for protein modelling that is applicable to the design of drugs, peptide vaccines and novel proteins is described. Our approach is knowledge-based, depending on the structures of homologous or analogous proteins and more generally on a relational data base of protein three-dimensional structures
Heseltine PN; Causey DM; Appleman MD; Corrado ML; Leedom JM; University of Southern California, School of Medicine, Los; Angeles.
Recurrent episodes of salmonellosis, including recurrent life-threatening bacteremias, have been well-described in patients with AIDS. Because of the need to avoid sensitization to trimethoprim-sulfamethoxazole (TMP-SFX) in AIDS patients and the high frequency of ampicillin resistance of Salmonella isolates, alternati
Homsy J; Thomson-Honnebier GA; Cheng-Mayer C; Levy JA; Cancer Research Institute, School of Medicine, University of; California, San Francisco 94143.
A micro-ELISA based on competition with the biotin-labeled 25 kDa gag (p25gag) recombinant protein of the human immunodeficiency virus (HIV) was compared to commercial antigen capture ELISAs for the detection of viral antigens in a variety of body fluids including serum, cerebro-spinal fluid (CSF), sputum, saliva, mil
Holliman RE; Public Health Laboratory Service, St George's Hospital, London,; U.K.
The literature on toxoplasmosis in the acquired immune deficiency syndrome is reviewed with reference to more than 140 cases from various centres. The incidence, pathogenesis, clinical features, diagnosis, treatment and prognosis are considered.
Young FE; Norris JA; Levitt JA; Nightingale SL; Office of Health Affairs, Food and Drug Administration,; Rockville, MD 20857.
The Food and Drug Administration has established new procedures to make promising investigational drugs available for treatment of patients with immediately life-threatening or serious diseases as early in the drug development process as possible and well before general marketing begins. The purpose of this article is
Med Clin North Am. 1988 May;72(3):691-715. Unique Identifier : AIDSLINE MED/88173803
Reines ED; Gross PA; Division of Infectious Diseases, Hackensack Medical Center, New; Jersey.
Potent effective antiviral drugs recently have been licensed for several viral diseases, ushering in a new era in the treatment of viral diseases. Several unique features in the process of a viral infection have been identified as target points for inhibition. The unique steps and the interfering compounds are the sub
Borghi V; De Palma M; Vecchi M; Pellegrino F; Mongiardo N; Cocchi I; De Rienzo B; Squadrini F; Department of Infectious Diseases, University of Modena, Italy.
A rapid, sensitive indirect immunofluorescence assay based on the use of acetone-fixed virus producing MOLT T4/LAV cells was adapted for the detection of anti-HIV antibodies. At the same time, 1486 serum samples, collected by the AIDS Surveillance and Study Centre of Modena, were tested by ELISA and IFA: the percentag
Garavelli PL; Azzini M; Universita di Pavia, Clinica delle Malattie Infettive.
Leukosis during HIV infection is extremely rare and up to now in Italy only 3 LLA, 1 LMA and 1 LMC have been described. Personal experience is reported and the pathogenesis of these neoplasias during AIDS and related syndromes is discussed.
Des Jarlais DC; Friedman SR; Stoneburner RL; New York State Division of Substance Abuse Services, New York; 10027.
As the second largest group of persons to have been infected with human immunodeficiency virus (HIV), and the most likely to transmit HIV to heterosexual partners in the United States and Europe, iv drug users will play an increasingly important role in the future of the AIDS epidemic.
Pauza CD; Developmental Biology Laboratory, Salk Institute, San Diego,; California 92138.
An hypothesis of the pathogenic mechanism leading to acquired immunodeficiency syndrome (AIDS) that places special emphasis on the potential for infected monocytes to act as the reservoir of a persistent human immunodeficiency virus (HIV) infection has been developed. Monocytes may mediate directly the infection and u
Henrion R; Port-Royal University Clinic, Paris, France.
Since the first cases of a new acquired immunodeficiency syndrome (AIDS) described by Oleske et al. and Rubinstein et al. in children in 1983, we have witnessed an ever-increasing number of such observations. As serology is not being performed on all pregnant women in many European countries, obstetricians must try to
Van de Perre P; Nzaramba D; Allen S; Riggin CH; Sprecher-Goldberger S; Butzler JP; AIDS Project, Belgian Rwandese Medical Cooperation, Kigali,; Rwanda.
Three commercially available assays for the detection of human immunodeficiency virus (HIV) antibodies-Vironostika enzyme immunoassay (EIA), Wellcozyme competitive EIA, and JLC Allaman indirect immunofluorescence assay--were tested on 300 serum samples from African subjects with and without HIV-related conditions. Two
Kwang HS; Barr PJ; Sabin EA; Sujipto S; Marx PA; Power MD; Bathurst IC; Pedersen NC; Department of Medicine, School of Veterinary Medicine, University; of California, Davis 95616.
The gp70 and transmembrane gp20 envelope proteins of simian retrovirus-D serotype 1 (SRV-1) were expressed in Saccharomyces cerevisiae as fusion proteins with human superoxide dismutase (SOD). Expression of the SOD-gp70 and SOD-gp20 sequences yielded fusion proteins of 52 and 29 kilodaltons, respectively. The yeast-ex
JAMA. 1988 May 6;259(17):2574-9. Unique Identifier : AIDSLINE MED/88188301
Schwartz JS; Dans PE; Kinosian BP; Department of Medicine, University of Pennsylvania, Philadelphia.
Human immunodeficiency virus (HIV) tests are essential for detecting asymptomatic infection and are helpful in confirming the diagnoses of acquired immunodeficiency syndrome-related complex and acquired immunodeficiency syndrome. Nonetheless, many aspects of their use remain controversial, partly because of concerns a
Proc Natl Acad Sci U S A. 1988 Apr;85(8):2449-53. Unique Identifier : AIDSLINE MED/88190089
Graves MC; Lim JJ; Heimer EP; Kramer RA; Department of Molecular Genetics, Hoffmann-La Roche, Nutley, NJ; 07110.
In order to define the protease domain of human immunodeficiency virus 1, various regions of the pol open reading frame were cloned and expressed in Escherichia coli. Antiserum directed against the conserved retroviral protease active site was used to identify pol precursor and processed species containing the presume
Proc Natl Acad Sci U S A. 1988 Apr;85(8):2763-6. Unique Identifier : AIDSLINE MED/88190148
Baldwin GC; Gasson JC; Quan SG; Fleischmann J; Weisbart R; Oette D; Mitsuyasu RT; Golde DW; Division of Hematology-Oncology, University of California School; of Medicine, Los Angeles 90024-1678.
We conducted a clinical trial of human recombinant granulocyte-macrophage colony-stimulating factor (rGM-CSF) in leukopenic patients with acquired immunodeficiency syndrome (AIDS) and analyzed neutrophil function before, during, and after in vivo administration of rGM-CSF. Prior to GM-CSF infusion, AIDS patients neut
S Afr Med J. 1988 Apr 16;73(8):455-60. Unique Identifier : AIDSLINE MED/88190970
Ijsselmuiden CB; Steinberg MH; Padayachee GN; Schoub BD; Strauss SA; Buch E; Davies JC; de Beer C; Gear JS; Hurwitz HS; Department of Community Health, University of the Witwatersrand,; Johannesburg.
In this, the first of a three-part series of articles in which we propose steps towards a comprehensive strategy for the control of HIV infection, we consider briefly the world-wide experience with the HIV epidemic. Our objective is to highlight the problems and controversial issues which are pertinent to strategies f
S Afr Med J. 1988 Apr 16;73(8):461-4. Unique Identifier : AIDSLINE MED/88190971
Ijsselmuiden CB; Steinberg MH; Padayachee GN; Schoub BD; Strauss SA; Buch E; Davies JC; de Beer C; Gear JS; Hurwitz HS; Department of Community Health, University of the Witwatersrand,; Johannesburg.
In this, the second of a three-part series of articles in which we propose steps towards a comprehensive strategy for the control of HIV infection, we consider controversies relating to screening for HIV, the indications for and desirability of mandatory testing of certain groups at risk, and the place of voluntary te
S Afr Med J. 1988 Apr 16;73(8):465-7. Unique Identifier : AIDSLINE MED/88190972
Ijsselmuiden CB; Steinberg MH; Padayachee GN; Schoub BD; Strauss SA; Buch E; Davies JC; de Beer C; Gear JS; Hurwitz HS; Department of Community Health, University of the Witwatersrand,; Johannesburg.
In this, the third of a three-part series of articles in which we emphasise the urgent need for and propose steps towards a comprehensive strategy for the control of HIV infection, we highlight the fundamental importance of an education campaign and the three critical essentials for a successful campaign. The first co
Carter TR; Cooper PH; Petri WA Jr; Kim CK; Walzer PD; Guerrant RL; Department of Pathology, University of Virginia, Charlottesville.
The authors describe a patient with acquired immune deficiency syndrome (AIDS) who presented with an acute abdomen. A plaque-like tumor of the small intestine was resected and found to consist of masses of Pneumocystis carinii organisms. The organisms also exhibited a perivascular and intravascular distribution. Ident
Dowsett AB; Roff MA; Greenaway PJ; Elphick ER; Farrar GH; Experimental Pathology Laboratory, PHLS Centre for Applied; Microbiology and Research, Porton Down, Salisbury, Wiltshire, UK.
An HIV-1 isolate (designated GB8) was isolated from an asymptomatic AIDS patient and subsequently grown in the T-lymphocyte cell line JM. Electron microscopy showed that it is vesicles within the syncytia present in cultures of JM cells chronically infected with GB8, rather than the surface membranes of unfused cells,
Colebunders RI; Greenberg A; Nguyen-Dinh P; Francis H; Kabote N; Izaley L; Davachi F; Quinn TC; Piot P; Project SIDA, Department of Public Health, Kinshasa, Zaire.
In July 1986, a provisional clinical case definition of AIDS in children, developed by the World Health Organization (WHO) for surveillance purposes in Africa, was tested on 159 patients hospitalized in the Department of Pediatrics at Mama Yemo Hospital, Kinshasa,
Lange JM; de Wolf F; Krone WJ; Danner SA; Coutinho RA; Goudsmit J; Department of Virology, Academic Medical Centre, University of; Amsterdam, The Netherlands.
Using a modified immunoblot procedure we looked for early serological markers of disease progression in sequential serum samples from 30 initially symptomless HIV-infected homosexual men. Sixteen men who did not progress beyond persistent generalized lymphadenopathy (PGL) and did not develop HIV antigenaemia showed pe
Ujhelyi E; Buki B; Salavecz V; Banhegyi D; Horvath A; Fust G; Hollan SR; National Institute of Haematology and Blood Transfusion, Laszlo; Hospital, Budapest, Hungary.
A method previously used for studying the specificity of antibody components of circulating immune complexes in different diseases has been applied to analyse circulating immune complexes in HIV-infected patients. Antibodies against HIV antigens hidden in circulating immune complexes were studied in 14 sera from 13 pa
Beall GN; Lal S; Sattentau QJ; Weller IV; Beverley PC; Department of Medicine, Harbor-UCLA Medical Center, Torrance; 90509.
Several studies have produced evidence for anti-lymphocytic antibodies (ALA) in AIDS. We attempted to demonstrate ALA by immunofluorescent flow cytometry. Normal human peripheral blood lymphocytes (PBL) and the T-cell line, CEM, were incubated with sera from patients with AIDS, patients with chronic HIV infection and
Gordin FM; Willoughby AD; Levine LA; Gurel L; Neill KM; Department of Medicine, Veterans Administration Medical Center,; Washington, DC 20422.
Incidents of suboptimal care being rendered to AIDS patients have been documented. Using a voluntary anonymous questionnaire, we surveyed the employees of a large urban hospital in order to evaluate the knowledge, attitudes and professional behavior of the staff regarding AIDS. Responses were obtained from 1194 (60%)
Van de Perre P; Carael M; Nzaramba D; Zissis G; Kayihigi J; Butzler JP; AIDS Project, Kigali, Rwanda.
In January 1987, HIV antibodies were detected by means of an immunoenzymatic assay, indirect immunofluorescence and Western blot in 52 out of 302 male urban-based professionals and in 28 out of 150 health workers in Kigali, Rwanda . Univariate analysis showed an association between
Van de Perre P; Le Polain B; Carael M; Nzaramba D; Zissis G; Butzler JP; AIDS Project, Kigali, Rwanda.
Detection of HIV antibodies by means of an immunoenzymatic assay, an indirect immunofluorescence technique and Western blot was attempted on 375 serum samples collected in the Murunda area, a remote rural area situated in Rwanda , central Africa. Two out of 147 (1.4%) adults from a
Mhalu F; Bredberg-Raden U; Mbena E; Pallangyo K; Kiango J; Mbise R; Nyamuryekunge K; Biberfeld G; Muhimbili Medical Centre, University of Dar es Salaam, Tanzania.
During 1986 sera from 2508 individuals representing various groups of healthy subjects and patients in Dar es Salaam (the capital city of Tanzania ), Bukoba (the capital of Kagera region in the northwest corner of Tanzania), Arusha (in the northeast of Tanzania) and Mbeya (in the
The results of several serological surveys, carried out in Uganda in the last 2 years, show that HIV infection is present in a number of different groups of individuals. There is a wide range of seropositivity (0 to 67.7%) seen within Uganda. In the sexually inactive, whether prima
Christofinis G; Papadaki L; Sattentau Q; Ferns RB; Tedder R; Department of Medical Microbiology, University College and; Middlesex Hospital School of Medicine, London, UK.
Adherent human embryo brain cells have been infected with HIV. Cells replicating HIV were maintained in culture for seven sequential passes over 7 months and continued to produce HIV during that time. Human embryo brain cells displayed glial-cell morphology and expressed glial fibrillary acidic protein. Electron micro
A cohort of 84 homosexual men presenting with persistent generalized lymphadenopathy (PGL) was studied between March 1982 and March 1987. A progression rate to AIDS of 5% per year was seen in those who were infected with HIV. Certain clinical features and routine laboratory investigations were significantly associated
Fox R; Odaka NJ; Brookmeyer R; Polk BF; Department of Epidemiology, Johns Hopkins School of Hygiene and; Public Health, Baltimore, MD 21205.
During a prospective study of the natural history of AIDS, 1001 homosexual or bisexual men were offered the opportunity to learn their HIV antibody status. Six hundred and seventy (67%) of the population who elected to do so were similar to the 331 (33%) people who declined in a number of baseline characteristics. All
Selwyn PA; Feiner C; Cox CP; Lipshutz C; Cohen RL; Montefiore Medical Center, Bronx, New York 10467.
Two hundred and sixty-one intravenous (IV) drug users, distributed between a methadone maintenance program and a large detention facility in New York City, were interviewed about knowledge of AIDS, needle use practices, and risk-reduction efforts. Ninety-seven per cent of subjects recognized needle-sharing as an AIDS
Br Med J (Clin Res Ed). 1988 Feb 13;296(6620):473-5. Unique Identifier : AIDSLINE MED/88164325
Evans BA; McCormack SM; Bond RA; MacRae KD; Thorp RW; Department of Genitourinary Medicine, West London Hospital,; London.
During the six months immediately after a public information campaign about the acquired immune deficiency syndrome 1115 women who attended a genitourinary medicine clinic in west London were tested for antibodies to the human immunodeficiency virus (HIV). Three women (0.27%) were positive, and all three were regular
Br Med J (Clin Res Ed). 1988 Feb 20;296(6621):526-9. Unique Identifier : AIDSLINE MED/88164351
France AJ; Skidmore CA; Robertson JR; Brettle RP; Roberts JJ; Burns SM; Foster CA; Inglis JM; Galloway WB; Davidson SJ; City Screening Clinic, City Hospital, Edinburgh.
Heterosexual transmission of human immunodeficiency virus (HIV) was investigated in 123 subjects with no apparent risk factor for infection other than having had heterosexual intercourse with a person who was either infected with HIV or at high risk of being infected with it. Seven subjects were found to be infected w
Br Med J (Clin Res Ed). 1988 Feb 20;296(6621):533-5. Unique Identifier : AIDSLINE MED/88164357
Milne RI; Keen SM; Department of Community Medicine, East Berkshire Health; Authority, Windsor, Berkshire.
General practitioners are excellently placed to assess a person s risk of being infected with the human immunodeficiency virus (HIV) and to give advice on reducing that risk. Their attitudes to the acquired immune deficiency syndrome (AIDS) and infection with HIV are, however, unknown. A questionnaire survey of 196 ge
Br Med J (Clin Res Ed). 1988 Feb 20;296(6621):535-7. Unique Identifier : AIDSLINE MED/88164358
Anderson P; Mayon-White R; Department of Community Medicine, Oxfordshire Health Authority.
General practitioners will have an increasingly important role in the management of patients with the acquired immune deficiency syndrome (AIDS) and infections with human immunodeficiency virus (HIV) as the numbers of cases increase. Altogether 280 general practitioners working in Oxfordshire were sent a postal questi
Br Med J (Clin Res Ed). 1988 Feb 20;296(6621):538-40. Unique Identifier : AIDSLINE MED/88164359
Boyton R; Scambler G; Royal Free Hospital School of Medicine, London.
As the numbers of people suffering from human immunodeficiency virus infection and the acquired immune deficiency syndrome (AIDS) increase, so will the contribution to care required from general practice. A postal questionnaire survey was therefore carried out among general practitioners in the North West Thames and E
Br Med J (Clin Res Ed). 1988 Feb 27;296(6622):593-8. Unique Identifier : AIDSLINE MED/88164384
Simmonds P; Lainson FA; Cuthbert R; Steel CM; Peutherer JF; Ludlam CA; Department of Bacteriology, University of Edinburgh.
Sequential serum samples from 18 haemophiliac patients exposed simultaneously to human immunodeficiency virus type 1 (HIV 1) in early 1984 were tested retrospectively for serological markers of infection. Assay for total antibodies to HIV established that the time to seroconversion might be as long as 110 days after e
Br Med J (Clin Res Ed). 1988 Mar 12;296(6624):745-50. Unique Identifier : AIDSLINE MED/88164430
Moss AR; Bacchetti P; Osmond D; Krampf W; Chaisson RE; Stites D; Wilber J; Allain JP; Carlson J; UCSF Department of Epidemiology and International Health, San; Francisco General Hospital 94110.
The three year actuarial progression rate to the acquired immune deficiency syndrome (AIDS) in a cohort of men in San Francisco who were seropositive for the human immunodeficiency virus (HIV) was 22%. An additional 26 (19%) developed AIDS related conditions. Beta 2 Microglobulin concentration, packed cell volume, HIV
Br Med J (Clin Res Ed). 1988 Mar 12;296(6624):755-8. Unique Identifier : AIDSLINE MED/88164437
Neville RG; McKellican JF; Foster J; Department of General Practice, Westgate Health Centre, Dundee.
A case-control study of heroin users in general practice showed a prevalence of roughly two per 1000 of the urban population or four per average general practice list of patients. A method of studying heroin users who attend general practice was used that has advantages over existing techniques. Thirty six heroin user
A highly purified plasminogen concentrate, LYS-PLASMINOGEN Steam Treated, has been developed for thrombolytic therapy of arterial and venous occlusions in combination with fibrinolytic agents. In search of a highly efficient drug covering this indication, we decided to select the lys-form of plasminogen because of its
Golding H; Robey FA; Gates FT 3d; Linder W; Beining PR; Hoffman T; Golding B; Division of Virology and Biochemistry and Physics, Food and Drug; Administration, Bethesda, Maryland.
Homologous regions of five amino acids each, were identified in the NH2-terminal domain of human class II beta chains and the COOH terminus of HIV I envelope protein. The homologous regions are highly conserved among different DR and DQ alleles and also among different isolates of HIV. Septamers containing these seque
Andes WA; Daul CB; deShazo RD; Palmer CH; Department of Medicine, Tulane University School of Medicine, New; Orleans, Louisiana.
The authors studied the natural history of human immunodeficiency virus (HIV) exposure in 187 hemophiliacs followed for an average of 45 months. Overall, 55 percent developed antibody specific for HIV and 21 percent developed persistent generalized lymphadenopathy. Most patients seroconverted sometime between early 19
Biochem J. 1988 Mar 1;250(2):485-91. Unique Identifier : AIDSLINE MED/88183370
Glover CJ; Goddard C; Felsted RL; Laboratory of Biological Chemistry, National Cancer Institute,; Bethesda, MD 20892.
A 16-residue synthetic peptide corresponding to the N-terminal sequence of p60src was used as the acyl acceptor in an assay for myristoyl-CoA:glycylpeptide N-myristoyltransferase in rat tissues. An additional C-terminal tyrosine amide was added to this peptide to facilitate radioiodination and enhance detectability. R
Smit Sibinga CT; Schulting PJ; Notebomer J; Das PC; Marrink J; v.d. Meer J; Red Cross Blood Bank, Groningen-Drenthe, The Netherlands.
In an attempt to implement the small pool concept in Factor VIII purification, cryoprecipitate derived from heparinised plasma was reprecipitated in the cold providing a factor VIII concentrate for freeze drying and heat treatment. There was considerable purification; only 1% of the original plasma proteins was left i
Nagumo T; Hoshino H; Third Department of Internal Medicine, Gunma University School of; Medicine.
The infectivity of human immunodeficiency virus (HIV) was inhibited by heparin, though de-N-sulfated heparin and heparin pretreated with protamine sulfate were hardly inhibitory. There was a correlation between the anticoagulant activities and anti-HIV activities of heparin-related compounds.
Becker J; Ulrich P; Kunze R; Gelderblom H; Langford A; Reichart P; Department of Oral Surgery, Faculty of Dentistry, Berlin.
Seventeen biopsies taken from oral mucosa of HIV infected patients were analysed for the distribution of CD4+/CD8+ T-lymphocytes and Langerhans cells. The results were evaluated statistically. An increase in the absolute number of CD4+ and CD8+ cells in HIV infected patients without clinical symptoms, ARC or AIDS was
Vuillier F; Lapresle C; Dighiero G; Unite d'Immunohematologie et d'Immunopathologie, Department de; Medecine, Institut Pasteur, Paris, France.
A comparative analysis of subsets (4B4 and 2H4) within the CD4 lymphocyte subpopulation was made by double marker analysis among 23 healthy heterosexual, 16 healthy HIV seronegative high-risk homosexuals and 82 HIV seropositive subjects. Data show that the significant increase in CD4 lymphocytes observed among seroneg
Arnold PA; Guglielmo BJ; Hollander H; Department of Pharmacy Services, Good Samaritan Medical Center,; Phoenix, AZ 85006.
A patient with acquired immunodeficiency syndrome (AIDS) developed rash, fever, neutropenia, and elevated liver function tests during an initial course of trimethoprim-sulfamethoxazole (TMP-SMX) therapy. Upon reexposure to the drug, the patient experienced a severe anaphylactoid reaction associated with pulmonary edem
FASEB J. 1988 Mar 1;2(3):251-5. Unique Identifier : AIDSLINE MED/88167505
Lewis DE; Yoffe B; Bosworth CG; Hollinger FB; Rich RR; Howard Hughes Medical Institute, Houston, Texas.
Epidemiological data suggest that transmission of human immunodeficiency virus (HIV) occurs primarily by transference of virally infected cells. However, the efficiency of lytic productive infection induced by HIV after transmission of cell-associated virus vs. free virus is difficult to assess. The present studies co
Kannagi M; Chalifoux LV; Lord CI; Letvin NL; Harvard Medical School, New England Regional Primate Research; Center, Southborough, MA 01772.
The AIDS-like disease in rhesus monkeys induced by the simian immunodeficiency virus (SIV) has been used as a model to explore the nature of the T lymphocyte response after infection with viruses of the human immunodeficiency virus family. Activated CD8+ lymphocytes are present in increased numbers in the paracortex o
Presse Med. 1988 Mar 26;17(11):528-32. Unique Identifier : AIDSLINE MED/88176794
Blanche S; Veber F; Rouzioux C; Le Deist F; Debre M; Gaud C; Griscelli C; Departement de Pediatrie, INSERM U132, Paris.
HIV infection of the newborn is now known to result mostly from mother-to-foetus transmission. The risk of transmission is at least 40 p. 100. However, the circumstances of passage are little known, and there is no maternal virological parameter capable of evaluating individual risks. The disease is more severe in chi
The present study was undertaken to determine whether human PBL can be specifically focused to lyse cells infected with HIV-1 by mAb heteroconjugates that can bridge target and effector cells. A mAb directed against the central portion of HIV-1 glycoprotein gp110 was chemically cross-linked to a mAb directed against t
Maul DH; Zaiss CP; MacKenzie MR; Shiigi SM; Marx PA; Gardner MB; California Primate Research Center, University of California,; Davis 95616.
Simian acquired immunodeficiency syndrome is a fatal immunosuppressive disease caused by type D retroviruses such as simian acquired immunodeficiency syndrome retrovirus type 1 (SRV-1). The disease is characterized by generalized lymphadenopathy, opportunistic infections, and lymphoid depletion with defects in both hu
Proc Natl Acad Sci U S A. 1988 Apr;85(8):2733-7. Unique Identifier : AIDSLINE GENBANK/J03776
Patarca R; Freeman GJ; Schwartz J; Singh RP; Kong QT; Murphy E; Anderson Y; Sheng FY; Singh P; Johnson KA; et al; Dana-Farber Cancer Institute, Department of Pathology, Harvard; Medical School, Boston, MA.
The Rpt-1 (for regulatory protein, T-lymphocyte, 1) gene, selectively expressed by resting but not by activated CD4+ inducer T cells, encodes an intracellular protein (rpt-1, Mr 41,000) that down-regulates gene expression directed by the promoter region of the gene encoding interleukin 2 receptor alpha chain and by th
Selik RM; Starcher ET; Curran JW; AIDS Program, Centers for Disease Control, Atlanta, GA 30333.
To look for associations and trends in the reported frequencies of particular opportunistic diseases in AIDS patients, we analyzed diseases in the 30,632 AIDS patients in the United States reported to the Centers for Disease Control (CDC) by 9 February 1987. Compared with all other AID
Matthews TJ; Langlois AJ; Robey WG; Chang NT; Gallo RC; Fischinger PJ; Bolognesi DP; Department of Surgery, Duke University Medical School, Durham,; North Carolina 27710.
By analogy to other retroviruses, the major envelope glycoprotein gp120 - of HTLV-III/LAV is a probable target for neutralizing antibody. This antigen has been purified from H9 cells chronically infected with the HTLV-IIIB prototype strain. Several goats immunized with the gp120 produced antibodies that neutralized in
Palker TJ; Clark ME; Sarngadharan MG; Matthews TJ; Department of Medicine, Duke University Medical Center, Durham,; NC 27710.
The external envelope glycoprotein (gp46) and transmembrane glycoprotein (gp21) of human T-cell lymphotropic virus type I (HTLV-I) were isolated from lysates of HTLV-I-infected HUT-102 cells by affinity chromatography. Fifty ml aliquots of packed HUT-102 cells were extracted with 1% Triton X-100, and lysates were trea
Boudreau S; Hines HC; Hood AF; Department of Dermatology, Johns Hopkins Medical Institutions,; Baltimore, Maryland.
A 34-year-old man with acquired immunodeficiency syndrome presented with multiple skin lesions clinically suggestive of molluscum contagiosum. Three skin biopsy specimens were obtained which showed dermal abscesses containing multiple gram-positive cocci admixed with granular necrotic dermal material. In 2, there were
Acheson DW; Leen CL; Tariq WU; Mandal BK; Regional Department of Infectious Diseases and Tropical Medicine,; Monsall Hospital, Manchester, U.K.
We report a case of recurrent varicella-zoster virus infection in a patient with severe acquired immune deficiency syndrome in whom the infection has become clinically unresponsive to treatment with acyclovir .
Hiramatsu K; Yonemoto R; Yoshikura H; Department of Microbiology, Faculty of Dentistry, Tokyo Medical; and Dental University, Japan.
Extrachromosomal human T cell leukaemia virus type 1 (HTLV-I) proviruses are persistently maintained in HTLV-I-infected human promyelocytic leukaemia (HL60) cells even 24 months after viral infection. By successive recloning of these HTLV-I-infected clones, and by Southern blot analysis of their HTLV-I proviruses, we
Electroretinographic (ERG) investigations were performed in three AIDS patients. The first had cotton wool-like spots in both eyes (AIDS retinopathy). The second presented with the same changes in his right eye and an acute cytomegalovirus (
Ross AM; Golub EE; Biochemistry Department, University of Pennsylvania, School of; Dental Medicine, Philadelphia 19104.
We have developed a computer graphics program system for the schematic representation of several protein secondary structure analysis algorithms. The programs calculate the probability of occurrence of alpha-helix, beta-sheet and beta-turns by the method of Chou and Fasman and assign unique predicted structure to each
Shea BF; Hoffman S; Sesin GP; Hammer SM; Northeastern University College of Pharmacy and Allied Health; Professions, Boston, Massachusetts.
A 33-year-old male with acquired immunodeficiency syndrome received ganciclovir for presumed cytomegalovirus retinitis. Although results of baseline liver function tests were abnormal, marked elevations of transaminases and alkaline phosphatase occurred when the drug was first inst
Proc Natl Acad Sci U S A. 1988 Apr;85(7):2071-5. Unique Identifier : AIDSLINE MED/88176888
Rosen CA; Terwilliger E; Dayton A; Sodroski JG; Haseltine WA; Dana-Farber Cancer Institute, Department of Pathology, Harvard; Medical School, Boston, MA 02115.
The art gene product of the human immunodeficiency virus is required for the expression of virion capsid and envelope gene proteins. The experiments presented here show that sequences located within the coding region of the envelope gene exert a negative effect on the expression of heterologous genes and that the nega
Frankel AD; Bredt DS; Pabo CO; Department of Molecular Biology and Genetics, Johns Hopkins; University School of Medicine, Baltimore, MD 21205.
Tat, the transactivating protein from HIV, forms a metal-linked dimer with metal ions bridging cysteine-rich regions from each monomer. This novel arrangement is distinct from the zinc finger domain observed in other eukaryotic regulatory proteins. Ultraviolet absorption spectra show that Tat binds two Zn2+ or two Cd2
Cheng-Mayer C; Seto D; Tateno M; Levy JA; Department of Medicine, University of California, School of; Medicine, San Francisco 94143.
Individuals infected with the human immunodeficiency virus type 1 (HIV-1) may be asymptomatic or have AIDS-related complex or the acquired immuno deficiency syndrome (AIDS). Little is known about the factors that influence progression of infection to AIDS. In this study of isolates of HIV-1 obtained at intervals durin
Fang CT; Williams AE; Sandler SG; Slamon DJ; Poiesz BJ; Jerome H. Holland Laboratory, American Red Cross, Rockville, MD.
Sera from 39,898 blood donors were tested for HTLV-1 antibodies using two enzyme immunoassays (EIA). Sera testing initially reactive (IR) were retested in duplicate by both EIAs. Sera testing repeatedly reactive (RR) were further tested by two Western blots (WB) and by two radioimmunoprecipitation assays (RIPA). There
In 3 patients seropositive for HIV 1 (2 homosexual men and 1 female drug addict), we found oral hairy leukoplakia on the lateral margin of their tongues. DNA of Epstein-Barr virus (EBV) and Human Papillomavirus (HPV) were identified in cellular DNA by molecular-virological means using Southern blot hybridization and/o
Am J Hematol. 1988 Jan;27(1):49-55. Unique Identifier : AIDSLINE MED/88180975
Ehrlich GD; Han T; Bettigole R; Merl SA; Lehr B; Tomar RH; Poiesz BJ; Department of Medicine, SUNY HSC, Syracuse 13210.
We describe a case of human T-lymphotropic virus type I (HTLV-I)-associated transient benign immature T-cell lymphocytosis in a black female patient, which over the course of several months underwent spontaneous complete remission. The patient presented with a white blood cell count of 20,000/microliter and a T4/T8 ra
Schweizer M; Corsten B; Neumann-Haefelin D; Abteilung Virologie, Klinikum der Universitat Freiburg, Federal; Republic of Germany.
DNA of the T-lymphotropic simian foamy virus (SFV) LK-3 was cloned in a plasmid vector and used as a probe in comparative DNA:DNA hybridization studies with primate foamy viruses (SFV serotypes 1, 2, 3, 5, 6, 7, 8, fresh SFV isolates from 12 African green monkeys and one rhesus monkey, as well as human syncytium formi
Dumontet C; Dodon MD; Gazzolo L; Gerlier D; INSERM U 218, Centre Leon Berard, Lyon, France.
HTLV-I has recently been shown to be a direct activator of resting human peripheral T cells. In order to determine the susceptibility of T-cell precursors to HTLV-I mitogenic activity we have exposed human thymic T cells to uv-inactivated HTLV-I. Unlike mature T cells, thymocytes were not directly susceptible to HTLV-
Rice AP; Mathews MB; Cold Spring Harbor Laboratory, New York 11724.
Human immunodeficiency virus-1 (HIV-1), which causes AIDS (acquired immune deficiency syndrome), possesses an essential gene, tat, whose product, acting through the long terminal repeat (LTR) sequences of HIV-1, activates viral genes and replication. The mechanism by which tat trans-activates HIV genes is unclear. Som
Klatt EC; Shibata D; Department of Laboratories and Pathology, Los Angeles; County-University of Southern California Medical Center 90033.
The clinical and autopsy findings of cytomegalovirus ( CMV ) infection in patients with the acquired immunodeficiency syndrome (AIDS) are reviewed. Of 164 patients, 81 had evidence of CMV infection at autopsy, but organ failure
Yamaguchi K; Kiyokawa T; Nakada K; Yul LS; Asou N; Ishii T; Sanada I; Seiki M; Yoshida M; Matutes E; et al; Department of Internal Medicine, Kumamoto University Medical; School, Japan.
We have studied 15 individuals (aged 14-74 years) with antibodies to HTLV-I in their serum and random integration of HTLV-I proviral DNA in their peripheral blood lymphocytes. All but one of these patients suffered from a variety of non-specific complaints which did not correspond to those of adult T-cell leukemia (AT
C R Acad Sci III. 1988;306(2):47-50. Unique Identifier : AIDSLINE MED/88164496
Ouattara A; Rey MA; Brun-Vesinet F; Kindbeiter K; de The G; Laboratoire d'Epidemiologie et Immunovirologie des Tumeurs,; Faculte de Medecine Alexis-Carrel, Lyon.
The study of 500 blood donors, of 23 prostitutes, 22 confirmed AIDS cases and 19 ARC patients in Abidjan showed that HIV-2 prevalence in blood donors (3.4%) was somewhat higher than that of HIV-1 (2.4%). Furthermore HIV-2 alone was found associated with 14% of AIDS cases and 21% of ARC, while HIV-1 was associated with
Uno H; Kawano K; Matsuoka H; Tsuda K; Department of Internal Medicine, Miyazaki Medical College, Japan.
HLA antigens of patients with adult T cell leukaemia (ATL), T cell malignant lymphoma (T-ML), and healthy carriers of human T cell leukaemia virus type I (HTLV-I) were investigated in an endemic area of ATL in Japan . Sixty-two patients with ATL were subdivided into three groups base
Katz MD; Erstad BL; Rose C; Department of Pharmacy Practice, College of Pharmacy, University; of Arizona, Tucson 85721.
Cryptosporidiosis commonly causes severe diarrhea in immunosuppressed patients. There currently are no antiparasitic drugs consistently effective for this infection. This case describes a 26-year-old hemophiliac patient with acquired immunodeficiency syndrome and cryptosporidiosis whose diarrhea improved with continuo
Haseltine W; Sodroski J; Rosen C; Dana-Farber Cancer Institute, Department of Pathology.
The broad outlines of mechanisms of tumorigenesis by the HTLV-I family of viruses are beginning to emerge. The viruses encode at least three genes in addition to the genes (gag, pol, and env) required for virus replication. These additional genes encoded for by the X region are likely to affect in a specific fashion t
Dosik H; Denic S; Patel N; Krishnamurthy M; Levine PH; Clark JW; Department of Medicine, Interfaith Medical Center, Brooklyn, NY; 11238.
Fifteen patients with adult T-cell leukemia/lymphoma (ATLL) were identified in less than a two-year period in the Crown Heights-Bedford Stuyvesant section of Brooklyn, NY. All patients were black; nine patients originated from the Caribbean islands and six from the southern United States
Ohtsu T; Tobinai K; Minato K; Mukai K; Kagami Y; Miwa M; Arai C; Shimoyama M; Department of Internal Medicine, National Cancer Center Hospital,; Tokyo.
A 49-year-old man developed adult T-cell leukemia (ATL) and acute myeloblastic leukemia (AML) at the same time. Using Southern blotting analysis, the leukemic cells of the ATL were found to contain the human T-cell leukemia virus type I (HTLV-I) proviral genome, whereas those of the AML did not, indicating the HTLV-I
Sakuma T; Satoh T; Satodate R; Madarame T; Onodera I; Suzuki Z; Itoh C; Second Department of Pathology, Iwate Medical University School; of Medicine.
A 60-year-old housewife was affected with adult T-cell leukemia (ATL) 10 years after her husband died of T-cell lymphoma, which was retrospectively diagnosed as ATL. She had never had a blood transfusion nor any indication of infection by human T-cell lymphotropic virus type I (HTLV-I) from her parents. The report sug
Robinson WE Jr; Montefiori DC; Mitchell WM; Vanderbilt University School of Medicine, Department of; Pathology, Nashville, Tennessee 37232.
Two components of human serum enhance human immunodeficiency virus type 1 (HIV-1) infection and mask HIV-1 neutralising antibody activity. The first is heat-stable, unique to HIV-1 seropositive sera, and is removed by protein-A chromatography. The second is heat-labile and ubiquitous; it is found in normal serum and i
Amadori A; de Rossi A; Giaquinto C; Faulkner-Valle G; Zacchello F; Chieco-Bianchi L; Interuniversity Center for Research on Cancer, University of; Padova, Italy.
To improve on the early diagnosis of human immunodeficiency virus (HIV) infection, 37 children born to HIV-infected mothers and 22 controls were investigated for in-vitro synthesis of IgG antibody directed against HIV components. For 14 of 16 infected children western blot showed HIV-specific IgG in the supernatants o
Jackson JB; Erice A; Englund JA; Edson JR; Balfour HH Jr; Department of Laboratory Medicine and Pathology, University of; Minnesota, Minneapolis.
We determined the prevalence of antibody to cytomegalovirus ( CMV ) in the sera of non-homosexual hemophilia patients and homosexual men infected with the human immunodeficiency virus type 1 (HIV-1). CMV antibody testing by lat
Kumagai E; Kumagai T; Tanoue S; Asou N; Yamaguchi K; Okabe H; Yoshida M; Takatsuki K; Department of Medical Technology, College of Medical Science,; Kumamoto University, Japan.
Serum levels of immunosuppressive acidic protein (IAP) were measured in patients with adult T-cell leukemia (ATL) in order to clarify its significance in this disease. The mean levels in patients with both acute (854 +/- 404 micrograms/ml) and chronic ATL (439 +/- 103 micrograms/ml) were significantly higher than in s
Am J Hematol. 1988 Jan;27(1):13-6. Unique Identifier : AIDSLINE MED/88180967
Chorba TL; Kalyanaraman VS; Lacher MJ; Schulof RS; Division of Field Services, Centers for Disease Control, Atlanta,; GA 30333.
Because of the T-cell abnormalities observed in Hodgkin s disease and the growing number of Hodgkin s disease cases observed in association with the acquired immunodeficiency syndrome (AIDS), concern has been expressed that a retrovirus may be the primary cause of Hodgkin s disease. We examined plasma specimens from 1
Am J Hematol. 1988 Apr;27(4):281-3. Unique Identifier : AIDSLINE MED/88180993
Denic S; Abramson J; Anandakrishnan R; Krishnamurthy M; Dosik H; Division of Hematology/Oncology, Interfaith Medical Center--State; University of New York Health Science Center, Brooklyn 11238.
Two patients, a daughter and her father, developed the acute type of adult T-cell leukemia/lymphoma (ATLL) within a 3-month period. Antibodies against HTLV-I have been found in both wives of the father. The second wife acquired the infection from her husband within 3 years of marriage. The patients described represent
Fukumoto S; Matsumoto T; Ikeda K; Yamashita T; Watanabe T; Yamaguchi K; Kiyokawa T; Takatsuki K; Shibuya N; Ogata E; Fourth Department of Internal Medicine, University of Tokyo; School of Medicine, Japan.
To clarify the mechanism of development of hypercalcemia in adult T-cell leukemia/lymphoma (ATLL), ten patients with a serum creatinine level less than 177 mumol/L (2 mg/dL) were examined. Although hypercalcemia was seen in only four (40%) of these patients, four of six normocalcemic patients showed hypercalciuria (gr
Yasuda N; Lai PK; Ip SH; Kung PC; Hinuma Y; Matsuoka M; Hattori T; Takatsuki K; Purtilo DT; Department of Pathology, University of Nebraska Medical Center,; Omaha.
Serum concentrations of soluble interleukin 2 receptors (sIL 2R) were measured by an enzyme-linked immunosorbent assay (ELISA) in 30 patients with adult T cell leukemia (ATL), in 9 patients with other hematopoietic malignancies, and in 17 asymptomatic individuals seropositive for human T cell leukemia virus type I (HT
A patient with a localized HTLV-I-associated lymphoproliferative disease that was misdiagnosed as Hodgkin s disease is presented. The patient s serum was negative for HTLV-I antibodies by enzyme-linked immunosorbent assay (ELISA), Western blot, and radioimmunoprecipitation. Tumor tissue DNA was negative for HTLV-I by
Cancer Res. 1988 May 1;48(9):2585-9. Unique Identifier : AIDSLINE MED/88184590
Posnett DN; McGrath HA; Scott RA; McNutt NS; Folkl R; Hickey TD; Macera MJ; Szabo P; Department of Medicine, Cornell University Medical College, New; York, New York 10021.
A patient with antibodies to human T-cell leukemia virus type I and the presence of integrated sequences of this virus in T-lymphocytes was investigated. In contrast to previous reports, the T-cell lymphocytosis was found to be polyclonal by analysis of human T-cell leukemia virus type I integration sites and T-cell a
To clarify the intrinsic factors involved in the manifestation of adult T-cell leukemia/lymphoma (ATL) in Japan , a third nation-wide study on ATL was conducted by the T- and B-cell Malignancy Study Group. General clinico-epidemiological findings on ATL and infectious modes of transm
In a married couple, a T-cell and a B-cell lymphoma occurred at the same time in the husband (FR) and wife (FE), respectively. Serum antibodies of patient FE with less advanced tumor progression specifically recognized HTLV-I-related envelope precursor molecules of 66-68 kDa molecular mass on HTLV-I-infected T- and B-
Daniel MD; Letvin NL; Sehgal PK; Schmidt DK; Silva DP; Solomon KR; Hodi FS Jr; Ringler DJ; Hunt RD; King NW; et al; New England Regional Primate Research Center, Harvard Medical; School, Southborough, MA 01772.
The prevalence of antibodies to 3 retroviruses in the macaque colony of the New England Regional Primate Research Center (NERPRC) was determined using enzyme-linked immunosorbent assay procedures as well as radioimmunoprecipitation-SDS polyacrylamide gel electrophoresis and indirect immunofluorescence tests. Out of 84
Miyamoto K; Matsuoka M; Tomita N; Suzuki C; Sato Y; Ishii A; Kitajima K; Nonaka H; Kondo T; Hiraki Y; et al; School of Health Sciences, Okayama University.
A B-cell line having translocations of chromosome 14 at break band q11 (the assigned locus of the alpha-chain gene of the T-cell antigen receptor) and chromosome 3 at break band p25 (the assigned locus of the c-raf-1 oncogene) was established from peripheral blood leukocytes of an adult T-cell leukemia (ATL) patient.
Tagaya Y; Okada M; Sugie K; Kasahara T; Kondo N; Hamuro J; Matsushima K; Dinarello CA; Yodoi J; Institute for Immunology, Faculty of Medicine, Kyoto University,; Japan.
Many human T cell lymphotropic virus-I (HTLV-I) transformed T cells from adult T cell leukemia (ATL) patients continuously produce a humoral factor called ATL-derived factor (ADF) which induces IL-2R/Tac expression on T and NK cells. Using gel filtration, procion red Sepharose, DEAE, and reverse phase chromatography,
Fleming AF; Tropical Diseases Research Centre, Ndola, Zambia.
The hypothesis that the true incidence of c-ALL is relatively uniform throughout the world is not supported by experience in tropical Africa, where ALL is uncommon under five years of age. A high rate of spontaneous somatic mutation in pre-B cells may initiate the development of c-ALL, but its progress could be determ
Weinhold KJ; Lyerly HK; Matthews TJ; Tyler DS; Ahearne PM; Stine KC; Langlois AJ; Durack DT; Bolognesi DP; Department of Surgery, Duke University Medical Center, Durham,; North Carolina.
Forty-one patients seropositive for human immunodeficiency virus type 1 (HIV-1) were assessed for cell-mediated cytotoxicity (CMC) against autologous target cells bearing the major envelope glycoprotein of HIV-1, gp120. Effector lymphocytes from over 85% of seropositive patients showed CMC specific for gp120-coated ta
S Afr Med J. 1988 Apr 16;73(8):481-3. Unique Identifier : AIDSLINE MED/88190977
Becker WB; Botha MC; Engelbrecht S; Becker ML; Department of Medical Virology, University of Stellenbosch and; Tygerberg Hospital, Parowvallei, CP.
Serological evidence for HTLV-I infection in the South African population has now been confirmed by the isolation of the virus from the peripheral blood lymphocytes of an adult Tsonga male. The subject was an indigenous black man from the south-eastern Transvaal who had suffered from Kaposi s sarcoma for a decade and
Jupp PG; Lyons SF; Department of Virology, University of the Witwatersrand,; Johannesburg, South Africa.
In vitro experiments were conducted to assess whether bedbugs (Cimex lectularius and Cimex hemipterus) and mosquitoes (Aedes aegypti formosus) could act as vectors of HIV. These insects engorged through a membrane on a blood-virus mixture. Female bedbugs were larger than males and took larger blood-meals when fed to r
McCune JM; Rabin LB; Feinberg MB; Lieberman M; Kosek JC; Reyes GR; Weissman IL; Department of Pathology, Stanford University School of Medicine,; California 94305.
The envelope protein of human immunodeficiency virus (HIV) is synthesized as a polyprotein (gp160) and cleaved intracellularly to a gp120-gp41 heterodimer. In this study, the tryptic-like endoproteolytic cleavage site was removed by site-directed mutagenesis and replaced with a chymotryptic-like site. The resultant mu
Tas M; Drexhage HA; Goudsmit J; Department of Pathology, Free University Hospital, Amsterdam, The; Netherlands.
This report describes that gp41, the transmembranous envelope protein of HIV, is able to inhibit monocyte chemotaxis (measured as FMLP-induced polarization). To study the presence of such immunosuppressive HIV env proteins in the circulation of HIV-infected men, fractions were prepared from serum via ultrafiltration,
Experientia. 1988 Mar 15;44(3):230-2. Unique Identifier : AIDSLINE MED/88167127
Grunberger D; Banerjee R; Eisinger K; Oltz EM; Efros L; Caldwell M; Estevez V; Nakanishi K; Comprehensive Cancer Center, College of Physicians and Surgeons,; Columbia University, New York, New York 10032.
The honeybee hive product, propolis, is a folk medicine employed for treating various ailments. Many important pharmaceutical properties have been ascribed to propolis, including anti-inflammatory, antiviral, immunostimulatory and carcinostatic activities. Propolis extracts have provided an active component identified
Harada S; Yamamoto N; Hinuma Y; Institute for Virus Research, Kyoto University, Japan.
Different isolates (HTLV-IIIB, LAV1 and ARV2) of human immunodeficiency virus (HIV) were cloned by a plaque-forming assay using MT-4 cells. The reverse transcriptase (RT) activity and plaque-forming unit (PFU) titers of all viral preparations were assayed. PFU/RT values, which indicate the relative proportions of inco
Stemler M; Hess J; Braun R; Will H; Schroder CH; Max Planck Institut fur Biochemie, Martinsried bei Munchen,; F.R.G.
Human sera were examined by immunoblotting for antibodies against the polymerase (reverse transcriptase) believed to be encoded in the P open reading frame (ORF) of human hepatitis B virus (HBV). Sera from patients with self-limited and chronic hepatitis reacted specifically with fusion proteins containing different d
Proc Natl Acad Sci U S A. 1988 Apr;85(7):2357-61. Unique Identifier : AIDSLINE MED/88176945
Berger EA; Fuerst TR; Moss B; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892.
Infection of helper T lymphocytes by human immunodeficiency virus is initiated by a specific interaction of the viral envelope glycoprotein with CD4, an integral membrane glycoprotein of the target cell. We have adapted a vaccinia virus-based mammalian cell expression system to produce variants of the CD4 molecule for
Walker BD; Flexner C; Paradis TJ; Fuller TC; Hirsch MS; Schooley RT; Moss B; Infectious Disease Unit, Massachusetts General Hospital, Harvard; Medical School, Boston, MA 02114.
Characterization of the host immune response to human immunodeficiency virus type 1 (HIV-1) is critical to the rational design of an effective AIDS vaccine. In this study, cytotoxic T lymphocytes (CTL) specific for HIV-1 reverse transcriptase (RNA-dependent DNA polymerase) were found in blood samples from HIV-1-infect
Ann Rheum Dis. 1988 Mar;47(3):206-9. Unique Identifier : AIDSLINE MED/88182419
Pelton BK; North M; Palmer RG; Hylton W; Smith-Burchnell C; Sinclair AL; Malkovsky M; Dalgleish AG; Denman AM; Connective Tissue Diseases Research Group, Clinical Research; Centre, Harrow, Middlesex.
Evidence for retroviral infection in general and human immunodeficiency virus (HIV) infection in particular was sought in freshly isolated peripheral blood T cells, B cells, and monocyte-macrophages from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) and also in T cell and B cell lines
Srinivasan A; Dorsett D; York D; Bohan C; Anand R; Retrovirus Diseases Branch, Centers for Disease Control, Atlanta,; Georgia.
Human immunodeficiency virus (HIV), the etiologic agent of AIDS, was found to infect and replicate in human brain cells. The extent of HIV replication was minimal in human brain-derived cells in comparison to T4 lymphoid cells. These results suggest that direct infection of glial/neuronal cells by HIV may contribute t
The Fairfield Hospital experience with isolation of HIV from peripheral blood leucocytes, cerebrospinal fluid and semen is described. To date HIV has been isolated from single specimens of blood from 45% of patients with AIDS, 35% of patients with lymphadenopathy syndrome AIDS-related complex or ARC and 14% of asympto
Starnes MC; Gao WY; Ting RY; Cheng YC; Department of Pharmacology, School of Medicine, University of; North Carolina, Chapel Hill 27514.
An activity gel analysis was performed in order to examine the catalytically active component of human immunodeficiency virus (HIV) reverse transcriptase in purified enzyme preparations and HIV-infected cell extracts. Immunoaffinity purified HIV reverse transcriptase contains two proteins with molecular weights 66,000
Viscidi R; Farzadegan H; Leister F; Francisco ML; Yolken R; Department of Medicine and Pediatrics, School of Medicine, Johns; Hopkins University, Baltimore, Maryland 21205.
A sensitive and specific avidin-biotin enzyme immunoassay that uses immunoreagents from naturally infected individuals was formulated for the detection of human immunodeficiency virus (HIV) antigens. A total of 500 cell culture samples from 111 cultures were tested in this assay and in a reverse transcriptase (RT) ass
Maurer B; Bannert H; Darai G; Flugel RM; Institut fur Virusforschung, Deutsches Krebsforschungszentrum,; Heidelberg, Federal Republic of Germany.
The nucleotide sequence of the human spumaretrovirus (HSRV) genome was determined. The 5 long terminal repeat region was analyzed by strong stop cDNA synthesis and S1 nuclease mapping. The length of the RU5 region was determined and found to be 346 nucleotides long. The 5 long terminal repeat is 1,123 base pairs lon
Ann Allergy. 1988 Apr;60(4):310-23. Unique Identifier : AIDSLINE MED/88192063
Steis RG; Longo DL; Division of Cancer Treatment, National Cancer Institute,; Frederick Cancer Research Facility, Maryland 21701.
The incidence of malignant disease in AIDS patients is around 40%. Ninety percent of the tumors are Kaposi s sarcoma and 10% are malignant lymphomas, predominantly of B cell origin. The natural history of the AIDS-associated Kaposi s sarcoma is variable. It may remain entirely asymptomatic without treatment for many m
Parthasarathy R; Kim H; Center for Crystallographic Research, Roswell Park Memorial; Institute, Buffalo, NY 14263.
The crystal structure of 3 -azido-3 -deoxy-thymidine ( AZT ), an antiviral agent that inhibits HIV reverse transcriptase, has been determined from three-dimensional x-ray diffractometer data. The crystal structure contains two independent molecules of A
This information is designed to support, not replace, the relationship that exists between you and your doctor.