[ACQUIRED IMMUNODEFICIENCY SYNDROME AND KAPOSI'S SARCOMA OF THE RECTUM IN A HOMOSEXUAL MAN. APROPOS OF A CASE IN RIO DE JANEIRO] NLM AIDSLINE Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

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[ACQUIRED IMMUNODEFICIENCY SYNDROME AND KAPOSI'S SARCOMA OF THE RECTUM IN A HOMOSEXUAL MAN. APROPOS OF A CASE IN RIO DE JANEIRO]

Rev Bras Cancerol; 31(2):169-72 1985. Unique Identifier : AIDSLINE ICDB/87636342
Carlos do Valle J; Da Rocha Nogueira A; Hospital de Oncologia, INAMPS, Rua Equador 831 - 2 andar, 20220; Rio de Janeiro, Brasil

Abstract: A 25-yr-old bisexual man presented with rectorrhagia which he attributed to hemorrhoids. A rectal tumor was found which proved to be a Kaposi sarcoma. Hyperpigmented, pruriginous lesions were also found on the back and forearms. Palpable lymph nodes were felt in the neck, axilla and inguinal region. The patient (pt) also tested positive for syphilis and hepatitis B markers. He denied having travelled outside Brazil, and he admitted to occasional use of marihuana but not intravenous drugs. The pt's immune system was hyporesponsive to skin tests and his helper:suppressor ratio was 0.78. Lymphocyte activation in response to mitogens was also deficient, even when compared with other Kaposi's sarcoma pts without AIDS. These data confirmed that the pt suffered from Kaposi's sarcoma secondary to AIDS, and he was treated with levamisole (2 mg/kg for 3 days in six 15-day cycles) resulting in less than 50% tumor reduction. Alpha interferon was administered (10,000,000 units/m2 im for 28 days). The rectal tumor responded completely to this treatment: two subsequent biopsies demonstrating no residual tumor. The pt remains under observation. (20 Refs)
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS/DIAGNOSIS Adult Case Report Homosexuality Human Interferon Type I/THERAPEUTIC USE Levamisole/THERAPEUTIC USE Male Rectal Neoplasms/*ETIOLOGY/THERAPY Sarcoma, Kaposi's/*ETIOLOGY/THERAPY Skin Neoplasms/ETIOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcomplications/diagnosisadultcasereporthomosexualityhumaninterferontypei/therapeuticuselevamisole/therapeuticusemalerectalneoplasms/KWDetiology/therapysarcoma,kaposi's/KWDetiology/therapyskinneoplasms/etiologyjournalarticle
880130
M8810373

Copyright © 1988 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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