ONCOGENES AND CELLULAR TRANSFORMATION BY HUMAN T-CELL LEUKEMIA VIRUS

Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

ONCOGENES AND CELLULAR TRANSFORMATION BY HUMAN T-CELL LEUKEMIA VIRUS

Gene Expression During Normal and Malignant Differentiation. Andersson LC et al, eds. New York, Academic Press, p. 183-209, 1985.. Unique Identifier : AIDSLINE ICDB/87637304
Ratner L; Wong-Staal F; Gallo RC; Lab. of Tumor Cell Biology, Developmental Therapeutics Branch,; Div. of Cancer Treatment, NCI, Bethesda, MD

Abstract: Molecular and biological characterization of human T-cell leukemia viruses (HTLV) I and II is summarized in reference to the isolation of HTLV, in vitro transformation, the acute or chronic nature of HTLV, the role of viral gene expression in transformation, the role of T-cell growth factor (TCGF) in transformation, genes activated by HTLV infection, and the role of c-sis activation in HTLV-transformed cells. The demonstration of a close association of HTLV-I with adult T-cell leukemia provided the first evidence for retroviral involvement in a human disease, and allowed the development of model systems to elucidate mechanisms of cellular transformation. Studies of variants of HTLV-I, including HTLV-II and HTLV-III, have demonstrated that a portion of the pX region designated LOR (long open reading frame) is involved in transformation, most likely as an activator of transcriptional enhancer activity. TCGF could be measured in the medium of some HTLV-transformed cell lines, but this was not a common finding, even though abundant TCGF receptors were universally present in HTLV-transformed cells. A gene, HT-3, differentially expressed in HTLV-transformed cell line HUT 102, was highly expressed in a number of HTLV-transformed cell lines. HT-3 expression also correlated with TCGF expression in several human hematopoietic cell lines. The expression of potentially truncated c-sis transcripts was also observed in HTLV-transformed cells. (75 Refs)

Keywords: Cell Line *Cell Transformation, Neoplastic *Cell Transformation, Viral Gene Expression Regulation Genes, Viral Human HTLV-BLV Infections/GENETICS HTLV-BLV Viruses/*GENETICS *Oncogenes Peptides/GENETICS Transcription, Genetic Virus Activation MEETING PAPER

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