HTLV AND HUMAN NEOPLASIA NLM AIDSLINE Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

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HTLV AND HUMAN NEOPLASIA

Gene Expression During Normal and Malignant Differentiation. Andersson LC et al, eds. New York, Academic Press, p. 211-9, 1985.. Unique Identifier : AIDSLINE ICDB/87637305
Golde DW; Wachsman W; Chen IS; Div. of Hematology-Oncology, Dept. of Medicine, UCLA Sch. of; Medicine, Los Angeles, CA 90024

Abstract: Studies of cell lines Mo and Mo-B, derived from the blood of a patient with hairy cell leukemia, and the subsequent isolation of human T-cell leukemia virus II (HTLV-II) are described, and the characteristics of human B and T cell neoplasias are discussed. The HTLV-II is a unique virus of the HTLV family associated with a relatively benign form of hairy cell leukemia. HTLV readily transforms T lymphocytes with helper surface antigen phenotype in vitro. Molecular analysis of HTLV-I and HTLV-II shows that they have distinct sequences but retain common transcription regulation signals in the long terminal repeat (LTR). The HTLV-II LTR normally functions only in lymphoid cells. Both viruses have a unique pX region believed to encode for transforming proteins. Defective HTLV-II genomes are associated with an Mo variant cell line showing in vitro characteristics of a high degree of malignancy. A concept of environmental requirements for neoplastic growth can explain the spectrum of degree of malignancy seen in neoplasms of a single cellular lineage. B- and T-cell neoplasias can be classified by their degree of malignancy without correlation to levels of cellular maturation. (28 Refs)
Keywords: Cell Line Cell Transformation, Neoplastic *Gene Expression Regulation Genes, Viral Human HTLV-BLV Infections/*GENETICS HTLV-BLV Viruses/*GENETICS MEETING PAPER

KWDcelllinecelltransformation,neoplasticKWDgeneexpressionregulationgenes,viralhumanhtlv-blvinfections/KWDgeneticshtlv-blvviruses/KWDgeneticsmeetingpaper
880130
M8810367

Copyright © 1988 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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