Impaired anti-pneumococcal antibody response in patients with AIDS-related persistent generalized lymphadenopathy. NLM AIDSLINE Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

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Impaired anti-pneumococcal antibody response in patients with AIDS-related persistent generalized lymphadenopathy.

Clin Exp Immunol. 1987 Jun;68(3):479-87. Unique Identifier : AIDSLINE MED/88003009
Ballet JJ; Sulcebe G; Couderc LJ; Danon F; Rabian C; Lathrop M; Clauvel JP; Seligmann M; Laboratory of Immunochemistry and Immunopathology (INSERM. U; 108), Hopital Saint-Louis, Paris, France.

Abstract: Pre- and post-immunization serum antibodies to pneumococcal polysaccharides (PPS) and tetanus toxoid (TT) were measured in 25 patients with persistent generalized lymphadenopathy and serum antibodies to the human immunodeficiency virus (HIV). The increase in post-immunization anti-PPS antibodies was lower than 40% in 16/25 patients. Isotype analysis indicated that the IgM, IgA, IgG2, but not the IgG1 antibody responses were lower in patients that in healthy controls, whereas pre-immunization values were similar. For TT, no difference was found between the patients and the healthy group in total and IgG1 antibody response whereas IgG4 response was lower in patients. No significant association was found between the defect in anti-PPS antibody response and associated thrush or constitutional symptoms or other immunological parameters. These findings suggest that defective response to a thymo-independent polysaccharide antigen is a distinctive consequence of HIV infection.
Keywords: Adult Antibodies, Bacterial/*BIOSYNTHESIS AIDS-Related Complex/*IMMUNOLOGY Bacterial Vaccines/*IMMUNOLOGY Female Human IgA/BIOSYNTHESIS IgG/BIOSYNTHESIS/CLASSIFICATION IgM/BIOSYNTHESIS Male Middle Age Streptococcus pneumoniae/*IMMUNOLOGY Tetanus Toxoid/IMMUNOLOGY JOURNAL ARTICLE

KWDadultantibodies,bacterial/KWDbiosynthesisaids-relatedcomplex/KWDimmunologybacterialvaccines/KWDimmunologyfemalehumaniga/biosynthesisigg/biosynthesis/classificationigm/biosynthesismalemiddleagestreptococcuspneumoniae/KWDimmunologytetanustoxoid/immunologyjournalarticle
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M8810347

Copyright © 1988 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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