Rev Bras Cancerol; 31(2):169-72 1985. Unique Identifier : AIDSLINE ICDB/87636342
Carlos do Valle J; Da Rocha Nogueira A; Hospital de Oncologia, INAMPS, Rua Equador 831 - 2 andar, 20220; Rio de Janeiro, Brasil
A 25-yr-old bisexual man presented with rectorrhagia which he attributed to hemorrhoids. A rectal tumor was found which proved to be a Kaposi sarcoma. Hyperpigmented, pruriginous lesions were also found on the back and forearms. Palpable lymph nodes were felt in the neck, axilla and inguinal region. The patient (pt) a
Oncogenes and Growth Control. Kahn P et al, eds. New York, Springer-Verlag, p. 43-50, 1986.. Unique Identifier : AIDSLINE ICDB/87637966
Heldin CH; Westermark B; Uppsala Branch of the Ludwig Cancer Institute for Cancer; Research, Biomedical Center, S-751 23 Uppsala, Sweden
Platelet-derived growth factor (PDGF) and related factors, together with their possible roles in autocrine and paracrine mechanisms in both normal and transformed cells, are reviewed. PDGF is composed of two disulfide-bonded polypeptide chains, denoted A and B. The amino acid sequence of the PDGF B chain is almost ide
Oncogenes and Growth Control. Kahn P et al, eds. New York, Springer-Verlag, p. 247-52, 1986.. Unique Identifier : AIDSLINE ICDB/87637993
Haseltine WA; Sodroski J; Rosen C; Goh WC; Dayton A; Celander D; Dana Farber Cancer Inst., Dept. of Pathology, Harvard Medical; Sch., Boston, MA 02115
Trans-activating genes found in the human T lymphotropic viruses (HTLVs) I, II, and III are reviewed with respect to structure, mechanism of action, and their role in the virus life cycle. The product of the longest open reading frame of HTLV-I and II corresponds to the transactivator (tat) protein; the rate of expres
Fundamentals of Surgical Oncology. McKenna RJ, Murphy GP, eds. New York, Macmillan Publishing Company, p. 114-40, 1986.. Unique Identifier : AIDSLINE ICDB/87638736
Bodey GP; McKenna RJ Jr; Univ. of Texas, Houston, TX
The immunocompromised cancer patient (pt) presents unique challenges in diagnosis and therapy. Increasingly, the surgeon is called upon to intervene in immunocompromised pts to assist in the diagnosis of infectious complications or in the therapy of the disease process. This has resulted from the lower risks of surgic
Mononuclear leukocytes from 14 cytomegalovirus ( CMV )-seropositive and 6 CMV-seronegative normal healthy donors were treated with soluble CMV antigen for 5 days to generate cytotoxic T-lymphocyte (CTL) activity. CMV-antigen st
Gene Expression During Normal and Malignant Differentiation. Andersson LC et al, eds. New York, Academic Press, p. 183-209, 1985.. Unique Identifier : AIDSLINE ICDB/87637304
Ratner L; Wong-Staal F; Gallo RC; Lab. of Tumor Cell Biology, Developmental Therapeutics Branch,; Div. of Cancer Treatment, NCI, Bethesda, MD
Molecular and biological characterization of human T-cell leukemia viruses (HTLV) I and II is summarized in reference to the isolation of HTLV, in vitro transformation, the acute or chronic nature of HTLV, the role of viral gene expression in transformation, the role of T-cell growth factor (TCGF) in transformation, g
Gene Expression During Normal and Malignant Differentiation. Andersson LC et al, eds. New York, Academic Press, p. 211-9, 1985.. Unique Identifier : AIDSLINE ICDB/87637305
Golde DW; Wachsman W; Chen IS; Div. of Hematology-Oncology, Dept. of Medicine, UCLA Sch. of; Medicine, Los Angeles, CA 90024
Studies of cell lines Mo and Mo-B, derived from the blood of a patient with hairy cell leukemia, and the subsequent isolation of human T-cell leukemia virus II (HTLV-II) are described, and the characteristics of human B and T cell neoplasias are discussed. The HTLV-II is a unique virus of the HTLV family associated wi
Oncogenes and Growth Control. Kahn P et al, eds. New York, Springer-Verlag, p. 128-34, 1986.. Unique Identifier : AIDSLINE ICDB/87637978
Hatakeyama M; Minamoto S; Mori H; Taniguchi T; Inst. for Molecular and Cell Biology, Osaka Univ., 1-3,; Yamadaoka, Suita-shi, Osaka 565, Japan
The main features of the human interleukin-2 receptor (IL2R) and the relationship of IL2R to T cell growth control are reviewed under the following headings: IL2-receptor binding; analysis of the IL2R/Tac antigen; phosphorylation of IL2R; IL2 as a growth inhibitor; IL2 and oncogene expression; and IL2R and adult T cel
Irrational responses to patient with AIDS, particularly in regards to the transmissibility of HIV (human immunodeficiency virus) are examined from an historical and psychosocial perspective. Although these responses are similar to those reported from past epidemics such as plague and leprosy, they are in direct confli
Ballet JJ; Sulcebe G; Couderc LJ; Danon F; Rabian C; Lathrop M; Clauvel JP; Seligmann M; Laboratory of Immunochemistry and Immunopathology (INSERM. U; 108), Hopital Saint-Louis, Paris, France.
Pre- and post-immunization serum antibodies to pneumococcal polysaccharides (PPS) and tetanus toxoid (TT) were measured in 25 patients with persistent generalized lymphadenopathy and serum antibodies to the human immunodeficiency virus (HIV). The increase in post-immunization anti-PPS antibodies was lower than 40% in
Ranki A; Weiss SH; Valle SL; Antonen J; Krohn KJ; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, Maryland.
Sequential serum samples, collected over a 2-3 year follow-up period, of 28 HIV-infected individuals were tested for the presence of neutralizing antibodies against one HIV isolate, HTLV-IIIB, and titrated, by Western blotting, against different HTLV-III specific proteins. Neutralizing antibodies were found in 66% of
Skinhoj P; Ersboll J; Nissen NI; Department of Internal Medicine and Haematology, Finsen; Institute, Rigshospitalet, Copenhagen, Denmark.
High grade malignant non-Hodgkin s lymphoma (NHL) was the presenting manifestation of the acquired immunodeficiency syndrome (AIDS) in 3/81 reported cases of AIDS in Denmark (by April 2, 1986). A
FEBS Lett. 1987 Oct 5;222(2):286-8. Unique Identifier : AIDSLINE MED/88005169
Maurer B; Flugel RM; German Cancer Research Center, Institute of Virus Research,; Heidelberg, FRG.
The primary amino acid sequence within a domain of 89 residues of the central part of the 3 -orf protein (p27 3 -orf) of human immunodeficiency virus (HIV-2) shares homology with the middle and carboxy-terminal portion of the bel3 gene product of human spumaretrovirus (HSRV). In addition, a limited region of the tat p
Ulirsch RC; Jaffe ES; Hematopathology Section, National Cancer Institute, Bethesda, MD; 20892.
Three cases of Sjogren s syndrome-like illness occurring in patients with the acquired immunodeficiency syndrome (AIDS)-related complex (ARC) are described. All three patients were male. Positive serologic tests for the human immunodeficiency virus (HIV) were documented in two; the third patient was a prison inmate wi
Twenty-nine homosexual patients with anorectal symptoms were investigated by sigmoidoscopy. Nineteen patients were anti-HIV antibody positive; in this group severe haemorrhagic proctitis was diagnosed in seven cases and purulent cryptitis with abscess formation and fistulation in three cases. All patients showed a red
Three types of human interferons (IFNs) are differentiated: alpha-interferon (with about 20 subtypes), beta-interferon, and gamma-interferon. In addition to their antiviral properties, these IFN types exert numerous other biological effects, which are increasingly exploited for therapeutic purposes. From 1982 to 1985
Valle BK; Lemberg L; Department of Medicine, University of Miami School of Medicine,; FL.
Cardiac manifestations of AIDS probably occur more frequently than is appreciated--despite autopsy reports indicating that more than 50% of deceased AIDS patients had myocarditis. A high index of suspicion and the echocardiogram will help in revealing the true incidence of cardiac involvement in AIDS.
Scully LJ; Shein R; Karayiannis P; McDonald JA; Thomas HC; Academic Department of Medicine, Royal Free Hospital Medical; School, London, U.K.
This study set out to examine the relative effectiveness and tolerability of 12- versus 24-week courses of thrice weekly intramuscular lymphoblastoid interferon in the treatment of hepatitis B e antigen (HBeAg)-positive chronic hepatitis B virus (HBV) infection, and to identify pretreatment factors predicting the ou
Quadland MC; Shattls WD; Mount Sinai Medical School, New York City, NY.
The AIDS epidemic is discussed in terms of its effect on general sexual attitudes and behavior of homosexual and bisexual men, then, in particular, on the issue of control over one s sexual behavior. Problems encountered in the formulation of the concept of sexual control are discussed along with relevant theoretical
Harowski KJ; Department of Family Practice and Community Health, University of; Minnesota Medical School, Minneapolis 55416.
This paper discusses the AIDS epidemic in terms of its impact on the psychology of individuals and their relationships. Special emphasis is given to treatment strategies that therapists may find useful in working with the worried well presenting with psychological and sexual difficulties in reaction to AIDS anxiety. I
Iosub S; Bamji M; Stone RK; Gromisch DS; Wasserman E; Department of Pediatrics, Metropolitan Hospital Center, New York,; NY 10029.
Eight patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex, ranging in age from 4 to 33 months, were evaluated for the presence of dysmorphic features recently described as human immunodeficiency virus embryopathy. Birth data and growth charts were available. Growth failure, a prominent box-
Alexander-Rodriguez T; Vermund SH; Spofford Juvenile Health Services, Montefiore Medical Center,; Bronx, NY 10467.
During a 1-year period from July 1983 to June 1984, 285 adolescent girls and 2,236 adolescent boys, ranging in age from 9 to 18 years (89% were 14 to 16 years of age), were screened for gonorrhea and syphilis on entry into a detention facility in New York City. The prevalence rate for gonorrhea was 3% for boys and 18.
Reath DB; Noone RB; Columbus M; Murphy JB; Service of Plastic Surgery, Bryn Mawr Hospital, Pa.
A case of Kaposi s sarcoma of an intraparotid lymph node in a patient with previously undiagnosed AIDS is presented. In patients at risk for AIDS who present with undiagnosed head and neck tumors, the diagnosis of epidemic Kaposi s sarcoma should be considered. Although transmission of AIDS to health care workers is e
Groopman JE; Klein HG; Levine PH; Redfield RR; Sande MA; Division of Hematology/Oncology, New England Deaconess Hospital,; Harvard Medical School, Boston.
Duncanson FP; Hewlett D Jr; Maayan S; Estepan H; Perla EN; McLean T; Rodriguez A; Miller SN; Lenox T; Wormser GP; Department of Medicine of Lincoln Hospital, New York City, New; York.
The clinical findings in 13 drug abusers and one homosexual man with tuberculosis and the acquired immunodeficiency syndrome (AIDS) from New York City are described. Tuberculosis preceded the diagnosis of AIDS in nine of the 14 patients by a mean of 7 months and occurred within the same month in the remaining five. Th
Tumori. 1987 Aug 31;73(4):397-401. Unique Identifier : AIDSLINE MED/88018967
Parrinello AE; Legnami FA; Fiorilli M; Zecchinato F; Papetti C; Aiuti F; Department of Medicine, Legnago General Hospital, Verona, Italia.
The clinical and pathologic features of a Burkitt-like lymphoma in a bisexual HIV-sero-positive man are reported. Emphasis is placed on some histologic characteristics present in a hyperplastic lymph node removed 2 years before the development of the B-cell lymphoma.
Flavin DK; Frances RJ; Department of Psychiatry, New York Hospital, Cornell Medical; Center, White Plains 10605.
The Acquired Immune Deficiency Syndrome (AIDS) has rapidly emerged as a public health crisis of unusual proportion. Despite the attention given to the association of AIDS and parenteral substance use, the relationship between AIDS and other aspects of substance use disorders such as risk taking, disinhibition and lack
Ginzburg HM; MacDonald MG; Glass JW; National Institute of Allergy and Infectious Diseases, Bethesda,; Maryland 20892.
Minorities and women who are engaging in activities which place them at high risk for infection with HTLV-III are developing HTLV-III related illnesses including AIDS. In Northeastern urban areas the relatively large number of minorities who use intravenous drugs are responsible for producing large numbers of patients
Am J Hematol. 1987 Oct;26(2):115-24. Unique Identifier : AIDSLINE MED/88020997
Hargraves MA; Jason JM; Chorba TL; Holman RC; Dixon GR; Eastham CJ; Brownstein AP; Heine P; Agle DP; Evatt BL; Division of Health Education, Centers for Disease Control,; Atlanta, GA 30333.
The Patient Knowledge Assessment Study (PKAS) was conducted among 107 male hemophilic patients, aged 15 to 67 years, at 19 hemophilia treatment centers (HTC). Participants were given a 30-item questionnaire concerning the cause of acquired immunodeficiency syndrome (AIDS), the groups at risk, and modes of transmission
Am J Law Med. 1987;12(1):7-53. Unique Identifier : AIDSLINE MED/88021053
Gostin LO; Curran WJ; Clark ME
The spread of acquired immune deficiency syndrome (AIDS) demands a comprehensive and effective public health response. Because no treatment or vaccine is currently available, traditional infection control measures are being considered. Proposals include compulsory testing and screening of selected high risk population
Am J Med. 1987 Sep;83(3):551-4. Unique Identifier : AIDSLINE MED/88021077
Rolston KV; Hoy J; Department of Internal Medicine, University of Texas M.D.; Anderson Hospital and Tumor Institute, Houston 77030.
Three patients with acquired immune deficiency syndrome (AIDS), central nervous system toxoplasmosis, and hypersensitivity to sulfadiazine were given treatment with clindamycin plus pyrimethamine. All three showed improvement clinically with resolution of symptoms. Two patients had computed tomographic evidence of imp
Am J Psychiatry. 1987 Oct;144(10):1342-4. Unique Identifier : AIDSLINE MED/88021419
Beckett A; Summergrad P; Manschreck T; Vitagliano H; Henderson M; Buttolph ML; Jenike M; Inpatient Psychiatric Unit, Massachusetts General Hospital,; Boston 02114.
Major depression with psychotic features, dementia , and focal neurologic abnormalities appeared in a Haitian man without AIDS or other syndromes of immune compromise. Neurologic evaluation, including brain biopsy, was nondiagnostic, but CSF culture revealed human immunodeficiency v
Am J Surg. 1987 Oct;154(4):443-6. Unique Identifier : AIDSLINE MED/88021549
Hommel DJ; Brown ML; Kinzie JJ; Department of Radiation Oncology, Denver Presbyterian Hospital,; Colorado.
Initial manifestations of AIDS in the head and neck area occur frequently. In fact, up to 40 percent of patients may have involvement of the head and neck. The most common malignancies are Kaposi s sarcoma and non-Hodgkin s lymphoma . Since AIDS-related malignancies are a relatively
Ann Intern Med. 1987 Nov;107(5):664-74. Unique Identifier : AIDSLINE MED/88022230
Crumpacker C; Heagy W; Bubley G; Monroe JE; Finberg R; Hussey S; Schnipper L; Lucey D; Lee TH; McLane MF; et al; Divisions of Infectious Diseases, Harvard Thorndike-Dana Research; Laboratory, Boston, Massachusetts.
STUDY OBJECTIVE: To assess safety, tolerance, and the clinical and laboratory effects of oral ribavirin in patients with the acquired immunodeficiency syndrome (AIDS) and the AIDS-related complex. DESIGN: Three uncontrolled phase I trials of increasing duration: 14 days, 8 weeks, and 12 months. SETTING: Outpatient cli
Espanol T; Garcia-Armui R; Bofill A; Sune J; Bertran JM; Deparment of Immunology, Pediatric Hospital, R S Valle Hebron,; Barcelona, Spain.
Repeated bacterial infections are frequent in children with AIDS owing to the B cell abnormalities produced by HIV infection. We report on two infants who presented with hypogammaglobulinaemia and with no HIV antibodies, but with epidemiological, immunological, and clinical features of AIDS.
Klatt EC; Meyer PR; Department of Pathology, University of Southern California School; of Medicine, Los Angeles 90033.
The pathologic findings of the spleen at autopsy in 101 patients with the acquired immunodeficiency syndrome are described. Grossly visible lesions were present in 52 patients. Microscopically, the histologic patterns of red and/or white pulp could be classified into five groups: group 1, in white pulp only, was chara
Schneider PA; Abrams DI; Rayner AA; Hohn DC; Department of Surgery, University of California-San Francisco; 94143.
Immunodeficiency-associated thrombocytopenic purpura (IDTP) is a feature of the acquired immunodeficiency syndrome--related complex. Current therapeutic modalities for IDTP include splenectomy and the administration of corticosteroids or other agents. Empiric treatment of IDTP has been analogous to that for immunologi
Int J Dermatol. 1987 Sep;26(7):459-60. Unique Identifier : AIDSLINE MED/88006524
Torre D; Sampietro C; Fiori GP; Dietz A; Montanari M; Division of Infectious Diseases, General Hospital and Foundation; E. and S. Macchi, Varese, Italy.
We have observed a peculiar skin manifestation that resembles cutis marmorata in three patients with AIDS and may be included among the several clinical aspects of AIDS in pediatric patients. One of the three patients died 4 months after the diagnosis. In an another patient, the skin lesion is still present 2 years af
Rey F; Barre-Sinoussi F; Schmidtmayerova H; Chermann JC; Viral Oncology Unit, Institut Pasteur, Paris, France.
An assay for determining neutralizing antibodies in sera from individuals infected with HIV was developed. This assay is based on an inhibition of the cytopathic effect observed after HIV superinfection of the HTLV-1-positive cell-line MT4. Only about 10% of asymptomatic seropositive donors exhibit a high titre over 1
Saah AJ; Farzadegan H; Fox R; Nishanian P; Rinaldo CR Jr; Phair JP; Fahey JL; Lee TH; Polk BF; National Institute of Allergy and Infectious Diseases, Bethesda,; Maryland 20892.
A current concept of the serological response to human immunodeficiency virus (HIV) infection in humans is that antibodies to core antigens (p55, p24, and p15) are detectable earlier during initial stages of antibody production than antibodies against envelope antigens (gp160, gp120, and gp41). Comparative studies of
Lerche NW; Marx PA; Osborn KG; Maul DH; Lowenstine LJ; Bleviss ML; Moody P; Henrickson RV; Gardner MB; California Primate Research Center, University of California,; Davis 95616.
A 2.5-year epidemiologic study of a breeding group of rhesus monkeys (Macaca mulatta), which is a focus of endemic simian acquired immunodeficiency syndrome (SAIDS), demonstrated a strong association between the occurrence of SAIDS and infection with a type D retrovirus, SAIDS retrovirus serotype 1 (SRV-1). Of 23 heal
N Engl J Med. 1987 Oct 29;317(18):1114-21. Unique Identifier : AIDSLINE MED/88014059
Allain JP; Laurian Y; Paul DA; Verroust F; Leuther M; Gazengel C; Senn D; Larrieu MJ; Bosser C; Department of Medical Affairs, Abbott Laboratories, Abbott Park,; IL 60064.
To investigate the relation between human immunodeficiency virus (HIV) antigenemia and clinical manifestations of HIV infections, we studied 96 patients with hemophilia who were positive for HIV antibody, for a median of 34 months. Every 4 to 10 months a clinical and laboratory examination was performed and serum samp
Lynch DP; Naftolin LZ; Department of Pathology, University of Texas Dental Branch,; Houston.
Opportunistic fungal and parasitic infections account for a significant amount of the morbidity and the mortality associated with the acquired immune deficiency syndrome (AIDS). Oral fungal infections are limited primarily to Candida albicans. The first reported case of oral Cryptococcus neoformans infection in a pati
Glick M; Cohen SG; Cheney RT; Crooks GW; Greenberg MS; Hospital of the University of Pennsylvania, Department of Oral; Medicine, Philadelphia, PA 19104.
A palatal lesion was the initial manifestation of disseminated cryptococcosis in a patient with acquired immunodeficiency syndrome (AIDS). The diagnosis was initially verified with cytologic smears in situ and later confirmed with pathologic findings from an excisional biopsy specimen. As cryptococcosis is one of the
Proc Natl Acad Sci U S A. 1987 Oct;84(19):6924-8. Unique Identifier : AIDSLINE MED/88016202
Rusche JR; Lynn DL; Robert-Guroff M; Langlois AJ; Lyerly HK; Carson H; Krohn K; Ranki A; Gallo RC; Bolognesi DP; et al; Repligen Corporation, Cambridge, MA 02139.
The human immunodeficiency virus envelope gene was expressed in insect cells by using a Baculovirus expression vector. The protein has an apparent molecular mass of 160 kDa, appears on the surface of infected insect cells, and does not appear to be cleaved to glycoproteins gp120 and gp41. Goats immunized with the 160-
Ann Chir Gynaecol Suppl. 1987;202:83-7. Unique Identifier : AIDSLINE MED/88022417
Maenpaa J; Kangas L; Soderstrom KO; Gronroos M; Department of Obstetrics and Gynecology, University of Turku,; Finland.
From 1982 through 1986 the subrenal capsule assay (SRCA) was used to test the sensitivity of 304 gynecological malignant tumors to cytotoxic drug combinations. Most of the tumors were ovarian cancers. Ninety-five percent of the assays were evaluable. Histological and ultrastructural studies were performed on transplan
Resnick L; Shapshak P; Department of Dermatology, Mount Sinai Medical Center, Miami; Beach, FL 33140.
The Western blot and radioimmunoprecipitation assay (RIPA) appear to be the most specific tests available for the detection of antibodies directed against human immunodeficiency virus (HIV). An investigation of 678 HIV-seropositive samples from 518 patients by the Western blot assay indicates that the majority of pati
Mendes NF; Peixinho ZF; Longo IM; Moura NC; Beck C; Passos Junior GA; De-Lucca FL; Departamento de Microbiologia, Imunologia e Parasitologia, Escola; Paulista de Medicina, Sao Paulo, Brasil.
1. Immune RNA (iRNA) was extracted from the spleen of a sheep immunized with human immunodeficiency virus (HIV) antigens. 2. The transfer of cell-mediated immunity to HIV antigens was accomplished by injecting iRNA into a Cebus monkey, as evaluated in vitro by leukocyte migration inhibition. The in vitro treatment of
Pardalos G; Kanakoudi-Tsakalidis F; Malaka-Zafiriu M; Tsantali H; Athanasiou-Metaxa M; Kallinikos G; Papaevangelou G; First Department of Pediatrics, Aristotle University of; Thessaloniki, Greece.
Immunological abnormalities have been observed in many haemophiliacs receiving clotting factor concentrates. To determine whether similar changes also occur after repeated blood transfusions we estimated T cell subsets and cutaneous delayed hypersensitivity (CDH) in 50 multitransfused children with beta-thalassemia ma
Mizuma H; Zolla-Pazner S; Litwin S; el-Sadr W; Sharpe S; Zehr B; Weiss S; Saxinger WC; Marmor M; Laboratory Service, New York Veterans Administration Medical; Center, NY 10010.
Serum IgD levels in individuals infected with the human immunodeficiency viruses (HIV) were studied as a means of monitoring the character and timing of B cell activation in individuals with this infection. Significantly increased levels of IgD were characteristic of homosexual men who were HIV seropositive but asympt
Cameron PU; Dawkins RL; Armstrong JA; Bonifacio E; Department of Clinical Immunology, Royal Perth Hospital, Western; Australia.
Sequential immunoblotting was performed on 64 patients infected with human immunodeficiency virus (HIV). Antibody profiles were related to immune function, T subsets and clinical features. In 20 patients, lymph node biopsy revealed a relationship between progressive follicular destruction, low antibody titres and ultr
Dwyer J; Wood C; McNamara J; Williams A; Andiman W; Rink L; O'Connor T; Pearson H; Department of Pediatrics, Yale University School of Medicine.
We have studied both the humoral and cell mediated immune systems of 23 children with beta-thalassaemia major. In children who had not been splenectomized, a 3-fold expansion in the number of circulating B cells and a modest polyclonal gammopathy was present. Of these patients 70% had decreased numbers of circulating
Sternbach MS; Tsoukas C; Paquin M; Lajeunesse N; Strawczynski H; Canadian Red Cross Blood Transfusion Service, Montreal, Quebec.
Patients suffering from acquired immune deficiency syndrome (AIDS) succumb to opportunistic infections due to a generalized failure of their cell-mediated immune defenses. The monocyte-macrophage (M-M) system plays an important role in host defense against viruses, protozoa, mycobacteria, and tumours, all potentially
Vitale F; Portera M; De Crescenzo L; Lupo G; Russo Alesi D; Torregrossa MV; Romano N; Mauro L; Abbadessa V; Mancuso G; et al; Istituto di Igiene G. D'Alessandro, Universita degli Studi,; Palermo.
A seroepidemiological survey, carried out to evaluate the prevalence of antibodies to HIV in patients with ARC and in healthy individuals at risk for AIDS, showed the infection to be widespread in the groups at risk, namely in drug abusers and hemophiliacs. However, remarkable difference existed between the prevalence
Moeller JR; Strother SC; Sidtis JJ; Rottenberg DA; Department of Neurology, Memorial Sloan-Kettering Cancer Center,; New York, NY 10021.
The data obtained from measurements of regional rCMRglu using [18F]fluorodeoxyglucose (FDG)/positron emission tomographic (PET) data contain more structure than can be identified with group mean rCMRglu profiles or regional correlation coefficients. This additional structure is revealed by a novel mathematical-statist
Lepe-Zuniga JL; Mansell PW; Hersh EM; Department of Clinical Immunology and Biological Therapy, M.D.; Anderson Hospital and Tumor Institute, Houston, Texas 77030.
We determined the capacity of peripheral blood monocytes from 19 patients with acquired immune deficiency syndrome (AIDS) or related conditions (1 with lymphadenopathy, 8 with AIDS-related complex, and 10 with AIDS) to produce intracellular and extracellular interleukin-1 (IL-1) spontaneously and upon stimulation with
Sharp RA; Morley SM; Beck JS; Urquhart GE; Department of Haematology, Ninewells Hospital and Medical School,; Dundee, Scotland.
Unresponsiveness to skin testing with PPD and tetanus toxoid was commonly seen in patients with haemophilia A but not infected with human immunodeficiency virus but was uncommon in controls. Vaccination history indicated that the unresponsive patients had not been immunised in childhood. Other tests of immune competen
Civeira M; Prieto J; Morte S; Rinon M; Serrano M; University Clinic, University of Navarra, Pamplona, Spain.
Interleukin-2, a product of helper T cells, is essentially involved in the regulation of cell-mediated immunity. Two monocyte-derived factors, interleukin-1 and prostaglandin E2, influence interleukin-2 synthesis with opposite actions. To analyse immunoregulatory function in HBsAg-positive chronic active hepatitis, T
J Immunol. 1987 Oct 1;139(7):2263-7. Unique Identifier : AIDSLINE MED/88009083
Ljunggren K; Bottiger B; Biberfeld G; Karlson A; Fenyo EM; Jondal M; Department of Immunology, Karolinska Institute, Stockholm,; Sweden.
The presence of antibodies mediating antibody-dependent cellular cytotoxicity (ADCC) against human immunodeficiency virus (HIV)-infected target cells was investigated with 170 sera from patients with varying severity of HIV infection. Approximately 40% of sera from individuals representing all stages of infection were
Perry VH; Gordon S; Department of Experimental Psychology, Sir William Dunn School of; Pathology, University of Oxford, United Kingdom.
Mononuclear phagocytes which express the HIV entry receptor CD4 have been implicated as possible sites of virus replication in brain, but there is still considerable uncertainty as to which cells in the CNS express CD4 Ag. Although it is not susceptible to HIV infection the rat provides a model to define expression of
Nature. 1987 Oct 8-14;329(6139):545-6. Unique Identifier : AIDSLINE MED/88014209
Ramshaw IA; Andrew ME; Phillips SM; Boyle DB; Coupar BE; Department of Experimental Pathology, John Curtin School of; Medical Research, Australian National University, Canberra.
Vaccinia virus recombinants that express cloned genes encoding antigens of unrelated infectious agents, such as hepatitis B virus and human immunodeficiency virus (HIV), provide a new approach to the development of live vaccines. Although there is evidence that genetically engineered vaccinia viruses have reduced path
Proc Natl Acad Sci U S A. 1987 Oct;84(19):6845-9. Unique Identifier : AIDSLINE MED/88016186
Tong-Starksen SE; Luciw PA; Peterlin BM; Howard Hughes Medical Institute, Department of Medicine,; University of California, San Francisco 94143.
Human immunodeficiency virus (HIV), the causative agent of AIDS, infects and kills lymphoid cells bearing the CD4 antigen. In an infected cell, a number of cellular as well as HIV-encoded gene products determine the levels of viral gene expression and HIV replication. Efficient HIV-replication occurs in activated T ce
Am J Med. 1987 Sep;83(3):571-6. Unique Identifier : AIDSLINE MED/88021082
Wharton JM; Demopulos PA; Goldschlager N; Division of Cardiology, San Francisco General Hospital Medical; Center, California.
Pentamidine isethionate is a diamidine compound used in the treatment of a number of parasitic diseases, notably Pneumocystis carinii pneumonia. Although cases of sudden death have been reported during the administration of pentamidine, there have been no reported cases in the literature of pentamidine-associated arrh
Silvestri RC; Jensen WA; Zibrak JD; Alexander RC; Rose RM; Department of Medicine, New England Deaconess Hospital, Boston,; MA 02215.
Fever, hypotension, pulmonary infiltrates, and hypoxemia developed upon re-exposure to trimethoprim-sulfamethoxazole in 2 patients with the Acquired Immunodeficiency Syndrome. This reaction can mimic sepsis or the clinical worsening of underlying pulmonary opportunistic infection. The literature concerning adverse pul
Beth-Giraldo E; Giraldo G; De Biasi R; Miraglia E; Castello G; Monaco M; Perna M; Zarrilli D; Piazza M; Tullio Cataldo P; et al; Division of Viral Oncology, Instituto Nazionale Tumori,; Fondazione G. Pascale, Naples, Italy.
Jackson B; Sannerud K; Rhame F; Tsang R; Balfour HH Jr; Department of Laboratory Medicine and Pathology, University of; Minnesota Medical School, Minneapolis.
The reverse transcriptase (RT) assay for human immunodeficiency virus (HIV) is tedious, expensive, and nonspecific for HIV activity. Because the Retro-Tek viral capture assay (VCA) (Cellular Products, Inc., Buffalo, NY) is relatively quick, inexpensive, and specific for HIV antigens, we compared the sensitivity and sp
Wasser L; Talavera W; Department of Medicine, Beth Israel Medical Center, New York; 10003.
Cryptococcus neoformans is emerging as an important etiologic agent of disseminated infection in patients with the acquired immunodeficiency syndrome (AIDS). Little attention has been placed on the pulmonary expression of this systemic infection. We report five patients with AIDS and cryptococcosis with primary pulmon
Emerg Med Clin North Am. 1987 Aug;5(3):443-80. Unique Identifier : AIDSLINE MED/88004268
Labadie LL; Rhule RL; Department of Emergency Medicine, Sinai Hospital of Detroit,; Michigan.
The scope of this article includes disorders ranging from simple vaginitis to a perspective on acquired immunodeficiency syndrome. Gynecologic infections are an extremely common cause of visits to the Emergency Department, especially those in large inner cities. Pelvic inflammatory disease is the most serious of the i
O'Doherty MJ; Page CJ; Bradbeer CS; Shahmanesh M; Edwards A; Barlow D; Bateman NT; Croft DN; Department of Thoracic Medicine, St Thomas's Hospital, London.
Pulmonary permeability was assessed using the technique of 99mTc (technetium-99m) diethylene triamene pentacetic acid (DTPA) aerosol transfer in 10 patients who had antibodies to human immunodeficiency virus (HIV) and were non-smokers and in 20 HIV antibody positive smokers. Five patients had Pneumocystis carinii pneu
Lee MH; Sano K; Morales FE; Imagawa DT; Department of Pediatrics, Harbor-University of California Los; Angeles Medical Center, Torrance 90509.
A sensitive biochemical assay of viral reverse transcriptase (RT) was developed that is useful for both the detection and quantitation of human immunodeficiency virus (HIV), the agent responsible for acquired immune deficiency syndrome in humans. This assay gave a 20- to 40-fold increase in enzyme activity over the cu
Recombinant human immunodeficiency virus (HIV) env antigen was attached to polystyrene particles, and these complexes were used to develop the first latex agglutination assay for antibodies to HIV. A total of 95 positive and 116 negative human serum samples were assayed for antibodies to HIV by latex agglutination, an
Radin DR; Cohen H; Halls JM; Department of Radiology, University of Southern California School; of Medicine, Los Angeles 90033.
Acalculous inflammatory disease of the biliary tree is a recently recognized complication of acquired immunodeficiency syndrome (AIDS). Two men with AIDS and elevated serum alkaline phosphatase levels are reported. Computed tomography and cholangiography demonstrated biliary disease resembling sclerosing cholangitis.
Silverman S Jr; Division of Oral Medicine, University of California, San; Francisco 94143.
The dimensions of AIDS continue to increase. The number of people infected with the AIDS virus (HIV) grows and no effective vaccine or curative treatment is expected in the near future. This article describes the oral findings of AIDS and AIDS-related complex (ARC). It will help dentists in recognition, diagnosis, con
Getchell JP; Hicks DR; Svinivasan A; Heath JL; York DA; Malonga M; Forthal DN; Mann JM; McCormick JB; Centers for Disease Control, Atlanta, Georgia 30333.
JAMA. 1987 Oct 9;258(14):1924-8. Unique Identifier : AIDSLINE MED/88011580
Zuger A; Miles SH; Department of Medicine, University of Chicago Hospital and; Clinic.
The profound reluctance of some physicians to care for patients with acquired immunodeficiency syndrome prompted us to review medical responses to other historic plagues. No consistent professional tradition emerged. Many physicians, including Galen and Sydenham, fled from patients with contagious epidemic diseases. M
Med Cutan Ibero Lat Am. 1987;15(2):98-104. Unique Identifier : AIDSLINE MED/88012739
Betlloch Mas I; Jimenez Martinez A; Ramon Quiles D; Castells Rodellas A; Catedra de Dermatologia, Hospital Clinico, Universidad de; Valencia.
We report herein a case of Acquired Immunodeficiency Syndrome in a 38 years old man with Kaposi s sarcoma, which evolution was fulminant in some months. The clinical, pathological and pathogenic characteristics of Kaposi s sarcoma in this syndrome are discussed.
High producer cell lines were established by infecting Jurkat cells with either HTLV-IIIB from H9 cells or with STLV-IIImac from HUT-78 cells. The Jurkat cells produced both viruses at least 10 times more efficiently then the original cell lines; the pelleted virus from Jurkat cells was also less contaminated with non
In patients with AIDS, LAS and ARC a defect in producing lymphokines such as Interleukin 2 and Gamma-interferon is found. Possibilities of therapy are reported. Especially the immunostimulant properties of inosiplex are commented, and the first successful results of therapy are discussed.
Laporte JP; Meyohas MC; Eliaszewicz M; Najman A; Frottier J; Woehrle R; Service d'hematologie, Hopital Saint-Antoine, Paris.
We associated HPA 23 (inhibitor of the reverse transcriptase) to cyclosporin A (CSA) for two homosexual patients with positive HIV serology, who had a peripheral thrombocytopenia resistant after alone CSA treatment. HPA 23 was given for 15 days at a dose of 4 mg/kg/day in a 24 hours continuous perfusion. The circulati
Prose NS; Mendez H; Menikoff H; Miller HJ; Department of Dermatology, State University of New York-Health; Science Center, Brooklyn 11203.
Acquired immunodeficiency syndrome was first observed in children in 1982. Human immunodeficiency virus (HIV) is now known to be the etiologic agent of this disease complex. Children acquire the viral infection in utero or perinatally, or by receiving contaminated blood products. The cutaneous manifestations include p
Kanoh T; Ohno T; Harada S; Fujii H; Department of Internal Medicine, Faculty of Medicine, Kyoto; University.
Isolation of the human immunodeficiency virus (HIV) was performed in 5 seronegative patients with primary immunodeficiency diseases (IDDs) who had no or little ability to produce antibodies and received a large amount of intravenous gammaglobulin (IVG) for a long period. In this study cultured cells were considered to
Gendelman HE; Theodore TS; Willey R; McCoy J; Adachi A; Mervis RJ; Venkatesan S; Martin MA; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland 20892.
A cell line (8E5) containing a single defective copy of human immunodeficiency virus proviral DNA and producing noninfectious viral particles lacking reverse transcriptase (RT) and endonuclease proteins has recently been described (Folks, et al., (1986b) J. Exp. Med. 164, 280-290). In this report, the mutation in a fu
Huisman JG; Winkel IN; Lelie PN; Tersmette M; Goudsmit J; Miedema F; Central Laboratory, Netherlands Red Cross Blood Transfusion; Service.
A sensitive and specific radioimmunoprecipitation assay was developed for the detection and analysis of anti-HIV antibody response in human sera with the use of 125I-labelled purified HIV proteins with subsequent sodium-dodecylsulfate gel electrophoresis (125I-RIPA). The 125I-RIPA was shown to be as specific but at le
Wien Klin Wochenschr. 1987 Aug 7;99(15):536-9. Unique Identifier : AIDSLINE MED/88019526
Gschnait F; Schmidt BL; Schwarz T; Heinz FX; Kunz C; Dermatologische Abteilung im Krankenhaus der Stadt Wien-Lainz.
1,032 sera of diverse origin (AIDS risk groups, prostitutes, inpatients, blood donors) exhibiting a positive HIV (HTLV III/LAV) ELISA result (Organon and/or Abbott) were investigated with different HIV confirmation assays (Western blot, WB; immunofluorescence, IF; competitive enzyme immunoassay against cloned gp41- an
Am J Med Sci. 1987 Sep;294(3):211-3. Unique Identifier : AIDSLINE MED/88021138
Ledley GS; Sulica VI; Kao GF; Department of Internal Medicine, Georgetown University School of; Medicine, Washington, DC 20007.
A patient of Middle-Eastern descent developed Kaposi s sarcoma of the skin and lymph nodes after renal transplantation while receiving medical immunosuppression, including the use of cyclosporine. The clinical presentation of this patient resembled that of the HTLV-III-associated Kaposi s sarcoma. The tumors totally r
Hammer SM; Gillis JM; Department of Medicine, New England Deaconess Hospital, Boston,; Massachusetts.
The ability of granulocyte-macrophage colony-stimulating factor (GM-CSF) and 3 -azido-3 -deoxythymidine ( AZT ) to inhibit human immunodeficiency virus (HIV) in the U-937 monocytic cell line was examined. Acutely HIV-infected U-937 cells were exposed to
Sieratzki J; Thung SN; Gerber MA; Ferrone S; Schaffner F; Department of Medicine, Mount Sinai School of Medicine, New York,; NY 10029.
Human leukocyte antigen (HLA) class I molecules are normally detected on most nucleated cells, but not on hepatocytes, while the expression of HLA class II antigens is mainly restricted to certain cell types of the immune system. This normal distribution pattern may be altered in human liver in a variety of disorders,
A 1986 survey of seven hemophilia treatment centers in Pennsylvania (PA) has revealed that 22 hemophiliacs residing in PA have developed the acquired immunodeficiency syndrome (AIDS), representing 9.2% of the total 238 United States hemophiliac AIDS cases. These 22 included ten (45.5%)
Br Med J (Clin Res Ed). 1987 Jul 18;295(6591):191-3. Unique Identifier : AIDSLINE MED/88001338
Beck EJ; Cunningham DG; Moss VW; Harris JR; Pinching AJ; Jeffries DJ; Department of Community Medicine, St Mary's Hospital, London.
Trends in human immunodeficiency virus (HIV) counselling and antibody testing at a London clinic for sexually transmitted diseases showed substantial changes over a 12 month period. From around 100 a month in the summer of 1986 the numbers of people attending rose substantially to 276 in October 1986 and 475 in Novemb
Br Med J (Clin Res Ed). 1987 Jul 18;295(6591):193-5. Unique Identifier : AIDSLINE MED/88001339
Sonnex C; Petherick A; Adler MW; Miller D; Academic Department of Genitourinary Medicine, Middlesex Hospital; Medical School, London.
Between the end of September and mid-November 1986 the number of patients who requested antibody testing for human immunodeficiency virus (HIV) at this department increased by over 300%. This increase followed a media campaign that emphasised the potential heterosexual spread of HIV. After pretest counselling roughly
During 1985 many drug abusers who lived in Edinburgh were found to be infected with the human immunodeficiency virus (HIV). As a result an alternative counselling and screening clinic for testing for antibodies to HIV was established for use by drug abusers. Four hundred and forty one patients were counselled in the f
Donnelly RP; La Via MF; Tsang KY; Department of Basic and Clinical Immunology and Microbiology,; Medical University of South Carolina, Charleston.
Sera from patients with acquired immune deficiency syndrome (AIDS) were analysed for effects on normal lymphocyte interleukin 2 ( IL-2 ) production, IL-2 receptor (IL-2R) expression and levels of IL-2 dependent T cell proliferation. The presence of AIDS serum appeared to
Evensen SA; Ulstrup J; Skaug K; Froland SS; Glomstein A; Rollag H; Haematology Section, Oslo City Hospital, Norway.
334 of 389 (86%) registered Norwegians with coagulation factor defects were screened for antibodies to the human immunodeficiency virus (HIV) in 1985/1986. 21 persons were confirmed anti-HIV positive. They were all persons with clinically severe haemophilia A and represent 18.4% of 114 tested persons with severe haemo
Nakashima H; Matsui T; Yoshida O; Isowa Y; Kido Y; Motoki Y; Ito M; Shigeta S; Mori T; Yamamoto N; Department of Virology and Parasitology, Yamaguchi University; School of Medicine.
Glycyrrhizin sulfate (GLS) was synthesized and investigated for antiviral effect on the human immunodeficiency virus (HIV) in vitro in comparison with the parental anti-HIV compound glycyrrhizin (GL). In MT-4 cells after HIV infection, the virus-induced cytopathic effect and the expression of viral antigens were inhib
Minnefor AB; Oleske JM; Division of Allergy, Immunology, and Infectious Diseases,; University of Medicine and Dentistry of New Jersey-New Jersey; Medical School, Newark.
Experimental studies suggest that IGIV therapy can be highly effective in the prevention and treatment of infectious diseases in a number of different patient groups. Several intravenous immune globulins are available in the United States (Table 5). For the most part, these preparation
Public Health Rep. 1987 Sep-Oct;102(5):463-7. Unique Identifier : AIDSLINE MED/88016790
Hopkins DR; Centers for Disease Control, Atlanta, GA 30333.
The grave challenge posed by the recent pandemic of acquired immunodeficiency syndrome is not the first time mankind has faced such a threat. Useful lessons may be drawn from the successful global Smallpox Eradication Program and applied to the current campaign in the areas of surveillance, strategy, operations, and e
Public Health Rep. 1987 Sep-Oct;102(5):468-74. Unique Identifier : AIDSLINE MED/88016791
Lyter DW; Valdiserri RO; Kingsley LA; Amoroso WP; Rinaldo CR Jr; University of Pittsburgh, Department of Medicine, School of; Medicine.
Beginning in the latter part of 1985, 2,047 gay and bisexual men who were enrolled in the Pitt Men s Study, the Pittsburgh cohort of the Multicenter AIDS Cohort Study (MACS), were invited by mail to learn the results of their antibody test for HIV infection--human immunodeficiency virus infection. Participants were as
Ingerslev J; Bukh A; Wallevik K; Moller NP; Stenbjerg S; Department of Clinical Immunology, University Hospital Aarhus,; Denmark.
The known transmission of viral diseases, particularly AIDS (HIV, LAV, HTLV-III), has led to the mandatory use of virus-inactivated coagulation factor concentrates for treatment of bleeding disorders due to deficient or abnormal synthesis of the factor VIII/von Willebrand factor complex. The present investigation was
Allain JP; Frommel D; Bosser C; Gazengel C; Larrieu MJ; Sultan Y; Centre National de Transfusion Sanguine, Hopital; Pitie-Salpetriere, Paris, France.
Forty-six subjects (44 HIV antibody-positive) with some degree of immune deficiency (at least TH/TS ratio below 1) were randomly distributed into 4 treatment groups. Each group was assigned to 1 of 4 products to be used exclusively for a 1-year period: 1 concentrate was of intermediate purity and not heat-treated, and
The use of recombinant peptides based upon the repeated amino acid sequences of Plasmodium has been proposed for malaria vaccines. By reducing homologies of such peptide vaccines to host proteins, the possibility of autoimmune complications may be reduced, and the effective immune response may be enhanced. The Wilbur
Gupta S; Division of Basic and Clinical Immunology, University of; California, Irvine 92717.
Using monoclonal antibodies (anti-2H4 and anti-4B4), CD4+ (T4+) T cells are further subdivided into two major subpopulations of inducers of help (T4+4B4+) and inducers of suppression (T4+2H4+). To determine whether human immunodeficiency virus (HIV) infection results in the depletion of a subset of CD4+ cells, periphe
Antworth MV; Beck RW; Department of Ophthalmology, University of South Florida College; of Medicine, Tampa 33612.
The case of a 29-year-old former parenteral drug abuser who presented with a 3rd nerve palsy and contralateral ataxia is reported. The patient was found to have a positive HLTV-III titer and acquired immune deficiency syndrome was diagnosed. Computed tomography demonstrated two ring-enhancing lesions in the brain whic
N Engl J Med. 1987 Oct 15;317(16):978-85. Unique Identifier : AIDSLINE MED/88014035
Allegra CJ; Chabner BA; Tuazon CU; Ogata-Arakaki D; Baird B; Drake JC; Simmons JT; Lack EE; Shelhamer JH; Balis F; et al; National Cancer Institute, Clinical Center, Bethesda, MD 20892.
Preclinical studies have demonstrated that trimetrexate is a potent inhibitor of dihydrofolate reductase from Pneumocystis carinii. On the basis of this evidence, this lipid-soluble antifolate was used as an antipneumocystis agent in 49 patients with the acquired immunodeficiency syndrome (AIDS) and pneumocystis pneum
Thromb Haemost. 1987 Jun 3;57(3):294-7. Unique Identifier : AIDSLINE MED/88018649
Al-Mondhiry H; Department of Medicine, Pennsylvania State University, College of; Medicine, Hershey.
Platelet function abnormalities have been described in some patients with hemophilia. This study reports measurements of plasma beta-thromboglobulin (BTG) and platelet factor 4 (PF4), sensitive and specific markers of platelet alpha-granule release in 72 hemophiliacs. Patients were studied on multiple occasions depend
Wien Klin Wochenschr. 1987 Aug 7;99(15):531-5. Unique Identifier : AIDSLINE MED/88019525
Hutterer J; Fuchs D; Eder G; Hausen A; Knapp W; Koller U; Reibnegger G; Werner ER; Wachter H; Stingl G; et al; Department of Dermatology, University of Vienna.
Urinary neopterin, a sensitive marker for activation of cell mediated immunity, is compared to clinical and laboratory data in 5 patients with AIDS, in 15 patients with ARC and in 40 male subjects without AIDS-related clinical signs attending an AIDS outpatient clinic. The sensitivity of neopterin for AIDS-related dis
This study analyzes a method of indirect marking of T lymphocytes subpopulations using a 2nd antibody coupled to colloidal gold particles (Immunogold). There is an excellent correlation between this technique and the classical technique of indirect immunofluorescence. Immunogold enables an easy and rapid count of lymp
Am J Perinatol. 1987 Oct;4(4):305-7. Unique Identifier : AIDSLINE MED/88000019
Brady MT; Ng A; Department of Pediatrics, Ohio State University College of; Medicine, Columbus.
Concern over possible acquisition of acquired immune deficiency syndrome (AIDS) following blood transfusions has caused considerable anxiety for hospitalized patients who require blood products as part of their medical management. This anxiety is heightened due to the long incubation period between exposure and the de
Humphry RC; Weber JN; Marsh RJ; St George's Hospital, London.
Twenty-eight patients with either the acquired immune deficiency syndrome (AIDS) or persistent generalised lymphadenopathy (PGL) were studied prospectively as outpatients for up to one year. Six patients had fundal cotton wool spots at some stage of their follow-up and all six suffered opportunistic infections associa
Br Med J (Clin Res Ed). 1987 Aug 1;295(6593):293-6. Unique Identifier : AIDSLINE MED/88001391
Hofmann B; Lindhardt BO; Gerstoft J; Petersen CS; Platz P; Ryder LP; Odum N; Dickmeiss E; Nielsen PB; Ullman S; et al; Department of Clinical Immunology, State University Hospital,; Copenhagen, Denmark.
To identify factors that may predict the development of the acquired immune deficiency syndrome (AIDS) or AIDS related symptoms various immunological measurements were studied in a group of homosexual men attending screening clinics for AIDS in Copenhagen. Fifty seven men whose ratio of T helper lymphocytes to T suppr
EMBO J. 1987 Jul;6(7):1959-65. Unique Identifier : AIDSLINE GENBANK/X05500
Mengle-Gaw L; Rabbitts TH; Medical Research Council, Laboratory of Molecular Biology,; Cambridge, UK.
We describe a region of human chromosome 8q24 involved in variant Burkitt s lymphoma translocations, and where an interstitial deletion occurs in an HTLV-I+ ATL and three c-myc amplicons terminate. The deletion in the ATL DNA begins within 1.3 kb of the cloned Burkitt s lymphoma translocation breakpoint and ends withi
We report a 65-yr-old male with adult T-cell leukemia (ATL) who developed multiple myeloma (MM) concomitantly. Skin lesions and peripheral leukocytosis were noted during the 5-yr observation period. There was abnormal lymphocytosis with indented or lobulated nuclei in the peripheral blood and in the bone marrow. The n
Schneiderman DJ; Arenson DM; Cello JP; Margaretten W; Weber TE; Medicine Service, San Francisco General Hospital, California.
The spectrum of liver disease in patients with acquired immune deficiency syndrome (AIDS) and the clinical impact of diagnostic percutaneous liver biopsy in this population were evaluated by a retrospective review of hepatic histology, clinical features and laboratory data in 85 patients (26 biopsies, 59 autopsies). O
Strannegard O; Bjorkander J; Hellstrand K; Pacsa A; Hermodsson S; Hanson LA; Department of Clinical Virology, University of Goteborg, Sweden.
The production of interferon (IFN) after stimulation of peripheral blood mononuclear cells with Sendai virus or phytohemagglutinin was studied in patients with common variable immunodeficiency (CVID) or selective IgA deficiency. Cells from CVID patients produced significantly more Sendai virus-induced (alpha) and mito
Ferrante P; Castellani P; Barbi M; Bergamini F; Istituto di Virologia, Universita degli Studi di Milano.
Viral antibodies to measles, HSV-1, HSV-2, EBV and HTLB-III have been tested in 120 sera and 90 CFS of 78 MS patients, 21 other neurological diseases and 21 non neurological disease controls included in the Italian Multicenter MS case-control study. A significantly higher frequency of HSV-2 antibodies was found in the
Varmier O; Melioli G; Lillo F; Schito G; Repetto C; Ravegnani M; Battaglia M; Istituto Microbiologia-Universita Genova.
Several observations indicate that a retrovirus might be involved in the pathogenesis of multiple sclerosis (MS). We report that the sera from 40 Italian MS patients did not contain antibodies to the human T-lymphotropic type I (HTLV-I) and type III viruses (HTLV-III) at levels detectable by commercial ELISA kits. Nev
Caputo D; Ferrante P; Zaffaroni M; Ghezzi A; Cazzullo CL; Centro Studi Sclerosi Multipla, Gallarate.
Our study focused on the relationship between lymphocyte H/S ratios and antiviral antibodies. We have concluded a longitudinal survey of 29 clinically definite MS patients for 8 months seeking a possible correlation among clinical modifications, fluctuations of T-cell subsets and antiviral antibody titers. For this pu
Can Assoc Radiol J. 1987 Sep;38(3):227-8. Unique Identifier : AIDSLINE MED/88007796
Caroline DF; Hilpert PL; Russin VL; Department of Diagnostic Imaging, Temple University Hospital,; Philadelphia, Pennsylvania.
The spectrum of gastrointestinal tract infections observed in patients with acquired immune deficiency syndrome (AIDS) has been widening rapidly. Patients with cytomegaloviral ( CMV infection of the colon have been described predominantly as having cecal disease
Pauwels R; De Clercq E; Desmyter J; Balzarini J; Goubau P; Herdewijn P; Vanderhaeghe H; Vandeputte M; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
Human immunodeficiency virus (HIV) infection of MT-4 cells, an HTLV-I-transformed T-cell line, proved to be a rapid and sensitive assay system for the detection of potential antiviral drugs effective against the acquired immune deficiency syndrome (AIDS). Four days after HIV inoculation of the MT-4 cells, viral antige
Bentwich Z; Saxinger C; Ben-Ishay Z; Burstein R; Berner Y; Pecht M; Trainin N; Levin S; Handzel ZT; Ruth Ben Ari Institute of Clinical Immunology, Kaplan Hospital,; Rehovot, Israel.
We have studied 288 Israeli asymptomatic male homosexuals (MHS) to determine the prevalence of antibodies to HTLVI and HTLVIII and their correlation with impairments of the immune system and serum interferon (IFN). Seropositivity for HTLVI, HTLVIII, or both was found in 1.4, 8.3, and 0%, respectively. Significant decr
J Immunol. 1987 Oct 1;139(7):2329-37. Unique Identifier : AIDSLINE MED/88009093
Kleinerman ES; Lachman LB; Knowles RD; Snyderman R; Cianciolo GJ; Department of Cell Biology, University of Texas, M. D. Anderson; Hospital and Tumor Institute, Houston 77030.
The synthetic peptide CKS-17 has homology to a highly conserved region of the immunosuppressive retroviral envelope protein P15E, to envelope proteins of HTLV I, II, III, and to that encoded by an endogeneous C-type human retroviral DNA. CKS-17 inhibits the immune response of lymphocytes and the respiratory burst of h
J Immunol. 1987 Oct 1;139(7):2458-63. Unique Identifier : AIDSLINE MED/88009112
Ojo-Amaize EA; Nishanian P; Keith DE Jr; Houghton RL; Heitjan DF; Fahey JL; Giorgi JV; Center for Interdisciplinary Research in Immunology and Disease,; UCLA 90024.
The capacity of human immunodeficiency virus (HIV) antibody-positive sera from homosexually active men without acquired immune deficiency syndrome to lyse the HIV-infected T cell lines MOLT-4f and CCRF-CEM (CEM) in cooperation with lymphocytes from normal donors was investigated. Twenty-seven HIV antibody-positive ser
Richman DD; McCutchan JA; Spector SA; Department of Pathology, University of California, San Diego.
We have developed a nucleic acid hybridization assay for detecting human immunodeficiency virus (HIV) RNA in peripheral blood mononuclear cells. This assay can detect HIV RNA in 10(2) cultured lymphoblastoid cells infected with HIV; it only weakly crossreacts with the RNA of HTLV-I or HTLV-II. For 39 (80%) of 49 serop
Richman DD; Kornbluth RS; Carson DA; Department of Pathology, University of California, San Diego; 92161.
Primary human monocyte-derived macrophages (MDM) were shown to have diminished deoxynucleoside kinase activities compared to T lymphoblasts, and a reduced ability to phosphorylate dideoxynucleosides with anti-human immunodeficiency virus (HIV) activity. These drugs, azidothymidine (
List AF; Greco FA; Vogler LB; Department of Medicine, Vanderbilt University Medical Center,; Nashville, TN 37237.
Epstein-Barr virus (EBV) is a ubiquitous transforming virus of the herpes group showing tropism for B lymphocytes. Primary infection in normal hosts results in a transient lymphoproliferative disorder, acute infectious mononucleosis (IM), that is restricted by cytotoxic and suppressive lymphocytes. However, in the imm
Ball MJ; Department of Chemical Pathology, John Radcliffe Hospital,; Oxford.
Inactivation of human immunodeficiency virus (HIV), the retrovirus associated with the acquired immune deficiency syndrome (AIDS), can be achieved both by heating at 56 degrees C and by chemical disinfection with beta-propiolactone (BPL). Such treatment of specimens from patients with suspected AIDS or antibodies to H
Colak H; Akgun Y; Anadolu Universitesi, Tip Fakultesi, Infeksiyon Hast. Anabilim; Dali.
Anti-HTLV-III, CMV-IgG, CMV-IgM, HSV-2 IgG antibodies and HBsAg, anti-HBs, HBeAg, anti-HBe, anti-HBc antibodies detected by EIA in 40 female prostitutes. Anti-HTLV-III antibody detected none of the females. HSV-2 IgG antibodies found (+) all of the women. CMV-IgG antibodies found (+) in 19 women and CMV-IgM antibody f
Shneider MA; Rudenko NK; Kavsan VM; Bibilashvili RSh; Kraevskii AA
3 -Azido-2 ,3 -dideoxythymidine (az-T) inhibited effectively the reproduction of some retroviruses; among these viruses were the four serological subgroups of sarcoma Raus virus in chicken embryo, avian myeloblastosis virus and erythroblastosis virus in chicken. This inhibition was specific towards retroviruses and pr
Mazurenko NN; Gladkova TI; Mikhaleva II; Antonenko VV; Prudchenko IA
To generate the antibodies to the transforming protein (p28sis) of simian sarcoma virus (SSV), the rabbits were immunized with peptides, corresponding to 200-206 and 201-210 sequences of p28sis, conjugated with protein carriers by different ways. The synthesis of peptides was carried out by the classical techniques in
Nature. 1987 Oct 15-21;329(6140):654-6. Unique Identifier : AIDSLINE MED/88014242
Katoh I; Yasunaga T; Ikawa Y; Yoshinaka Y; Laboratory of Molecular Oncology, Tsukuba Life Science Center,; Institute of Physical and Chemical Research, Ibaraki, Japan.
Retrovirus protease is an enzyme that cleaves gag and gag-pol precursor polyproteins into the functional proteins of mature virus particles. The correct processing of precursor polyproteins is necessary for the infectivity of virus particles: in vitro mutagenesis which introduces deletions into the murine leukaemia vi
A virally induced autoimmune reaction may be important in the pathogenesis of multiple sclerosis. The role that glycolipids and myelin basic protein presented to the virus may play in this process is considered. The most likely cells to be the source of autoantigens are neurons, myelin and oligodendrocytes. Viral infe
Holland GN; Sidikaro Y; Kreiger AE; Hardy D; Sakamoto MJ; Frenkel LM; Winston DJ; Gottlieb MS; Bryson YJ; Champlin RE; et al; UCLA Uveitis Center, Jules Stein Eye Institute, Los Angeles, CA; 90024.
Ganciclovir is an experimental antiviral drug with activity against human cytomegalovirus ( CMV ). Forty patients with acquired immune deficiency syndrome (AIDS) and CMV retinopathy were treated with ganciclovir on a compassion
Jabs DA; Newman C; De Bustros S; Polk BF; Department of Ophthalmology, Wilmer Ophthalmological Institute,; Johns Hopkins Hospital, Baltimore, MD 21205.
Eighteen immunocompromised patients with cytomegalovirus ( CMV ) retinitis were treated with ganciclovir, an investigational antiviral drug. CMV retinitis in association with acquired immune deficiency syndrome (AIDS) developed
Orellana J; Teich SA; Friedman AH; Lerebours F; Winterkorn J; Mildvan D; Department of Ophthalmology, Beth Israel Medical Center, New; York, NY 10003.
A total of 66 eyes in 41 patients were treated for cytomegalovirus ( CMV ) retinitis with a new acyclic nucleoside, ganciclovir (BW B759U). At the completion of the short-term therapy period of 21 days, 87.7% of eyes had stabil
Hashimoto H; Muller H; Muller F; Schmidts HL; Stutte HJ; Senekenbergisches Zentrum der Pathologie, Universitat Frankfurt; am Main, Federal Republic of Germany.
Cytomegalovirus ( CMV ) was assayed by in situ hybridization with commercially available biotin-labeled CMV-DNA probes in 45 formalin-fixed paraffin-embedded autopsy specimens with Kaposi s sarcoma from 14 cases of the acquired immune deficiency syndrome (AIDS). I
Montefiori DC; Mitchell WM; Department of Pathology, Vanderbilt University, School of; Medicine, Nashville, Tennessee 37232.
We previously demonstrated a high permissiveness of HTLV-II-transformed T lymphocytes (C3) to human immunodeficiency virus (HIV) infection in vitro, and that this infection results in the lysis of cells (D.C. Montefiori and W.M. Mitchell (1986) Virology 155, 726-731). We now show that a small percentage of HIV-infecte
Barbanti-Brodano G; Pagnani M; Viadana P; Beth-Giraldo E; Giraldo G; Corallini A; Institute of Microbiology, School of Medicine, University of; Ferrara, Italy.
Sanada I; Ishii T; Matsuoka M; Kumagai E; Nishimura H; Yamaguchi K; Takatsuki K; Blood Transfusion Service, Kumamoto University Medical School,; Honjo, Japan.
Cytogenetic studies were done in lymph node and peripheral leukemic cells from sixteen patients with non-Hodgkin lymphoma with peripheral T-cell type. Ten patients were positive for human T-cell leukemia virus I (HTLV-I) proviral DNA in tumour cells and six were negative. The former group had a higher tendency for leu
Weisenburger DD; Linder J; Armitage JO; Department of Pathology, University of Nebraska Medical Center,; Omaha 68105.
We analysed the clinical and pathologic features of 42 patients with immunologically confirmed peripheral T-cell lymphoma. The median age was 60 years and the male to female ratio was 1:1. A prior lymphoproliferative or autoimmune disorder was present in 14 per cent of the patients. Signs of advanced disease were usua
Nishio K; Department of Dermatology, School of Medicine, University of; Occupational and Environmental Health, Kitakyushu.
In 1976, adult T-cell leukemia (ATL) was reported as a special form of T-cell leukemia. In such cases the following criteria are prominent: strong inclination to leukemic change, incidence of abnormal cells in the peripheral blood, and the existence of an endemic area at the time of the outbreak of the disease. The ab
Baranski B; Young N; Clinical Hematology Branch, National Heart, Lung, and Blood; Institute, Bethesda, Maryland.
This article summarizes the current medical literature regarding the effects of viral infections upon the hematopoietic system. The article discusses the effect of viral infections upon peripheral blood counts, cellular immune system, and the bone marrow. In addition, a few selected syndromes, including human parvovir
Lancet. 1987 Oct 10;2(8563):827-8. Unique Identifier : AIDSLINE MED/88012874
Faber V; Dalgleish AG; Newell A; Malkovsky M; University Hospital of Copenhagen, Denmark.
A 58-year-old man with AIDS improved clinically after the introduction of fusidic acid, 500 mg three times a day orally, to his therapeutic regimen. Fusidic acid may have had a direct effect against HIV. Fusidic acid has anti-HIV activity in vitro at levels readily attainable in vivo. The drug does not appear to be a
Ikai K; Uchiyama T; Maeda M; Takigawa M; Department of Dermatology, Faculty of Medicine, Kyoto University,; Japan.
A 10-year-old girl with a Sezary-like syndrome is described. At age 6 months, her skin involvement began as psoriatic plaques. Generalized erythema, lymphadenopathy, and pruritus developed into erythroderma. Her general condition has been good in spite of severe pruritus and erythroderma. Atypical cells were found in
Goldman-Leikin RE; Herst CV; Kies MS; Variakojis D; Marder RJ; Rosen ST; Section of Medical Oncology, Northwestern University, Chicago,; IL.
Human T-cell lymphotropic virus type I (HTLV-I) is a unique retrovirus associated with specific malignancies of T cells in humans. The virus is endemic to Japan , the Caribbean, Africa, and the southeastern United States . We report here the first case
In: Witt, Michael D., ed. AIDS and Patient Management: Legal, Ethical and Social Issues. Owings Mill, Md.: National Health Publishing, 1986 :3-24. Unique Identifier : AIDSLINE KIE/23700
Available from Columbia Univ. Seminars on Media and Society, 204 Journalism, Columbia Univ., New York, N.Y. 10027; film (3/4 in.) $125; videocassette (1/2 in. VHS) $85, 1986 Videocassette or film; 60 min.; sd.; color Unique Identifier : AIDSLINE KIE/23903
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