Autoimmunity against blood cells in human immunodeficiency-virus (HIV) infection. NLM AIDSLINE Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

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Autoimmunity against blood cells in human immunodeficiency-virus (HIV) infection.

Br J Haematol. 1987 Sep;67(1):109-14. Unique Identifier : AIDSLINE MED/88024789
van der Lelie J; Lange JM; Vos JJ; van Dalen CM; Danner SA; von dem Borne AE; Department of Haematology, University of Amsterdam, The; Netherlands.

Abstract: In persons with AIDS or at risk from AIDS, autoantibodies against platelets and granulocytes were frequently detected. Platelet-bound immunoglobulins were demonstrated by immunofluorescence in all 16 patients with AIDS, in five out of seven patients with AIDS-related complex/persistent generalized lymphadenopathy (ARC/PGL) and even in seven of 10 healthy sexually active homosexual men. Granulocyte-bound immunoglobulins were found by immunofluorescence in 12 of the 16 AIDS patients, five of the seven patients with ARC/PGL and two of the 10 symptomless men. Red cell bound immunoglobulins were not detected. All patients with AIDS and ARC/PGL and three of the symptomless men were seropositive for human immunodeficiency virus (HIV). The platelet- and granulocyte-bound immunoglobulins could be eluted in 93% and 67% of the cases, respectively. This indicates that specific autoantibodies, rather than circulating immune complexes, which were frequently increased, accounted for the findings. There was no relation between the serological findings and the platelet and granulocyte counts. We conclude that autoantibodies against platelets and granulocytes are common in patients with AIDS and those at risk.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Adult Autoantibodies/*ANALYSIS AIDS-Related Complex/IMMUNOLOGY Blood Groups/IMMUNOLOGY Blood Platelets/*IMMUNOLOGY Granulocytes/*IMMUNOLOGY Homosexuality Human Male Middle Age JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDimmunologyadultautoantibodies/KWDanalysisaids-relatedcomplex/immunologybloodgroups/immunologybloodplatelets/KWDimmunologygranulocytes/KWDimmunologyhomosexualityhumanmalemiddleagejournalarticle
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M8820357

Copyright © 1988 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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