[Washington, D.C.] : U.S. Dept. of Health and Human Services, Public Health Service : For sale by the Supt. of Docs., U.S. G.P.O., 1987 1 v. (various pagings) Unique Identifier : AIDSLINE CAT/8800363
Korda H; Health Planning and Evaluation
Listing of refereed journal articles identified as being relevant to policy-making audiences. Journal articles were published between Jan. 1983, through mid-1985. Citations are arranged according to an outline set up by the PHS Executive Task Force on AIDS in the summer, 1986. Each entry gives author(s), title of ar
This volume is a collection of the papers presented at the International Ares-Serono Symposium on the Interferon (IFN) System, held in Rome on May 8-11, 1985. The following are the major section headings: production and characterization, physiology and toxicology, antiviral activity, receptors, clinical trials, antitu
Int J Immunotherapy; 2(4):295-300 1986. Unique Identifier : AIDSLINE ICDB/88639939
Grieco MH; Reddy MM; Moriarty ML; Manvar D; Ahuja KK; Bellomo S; Holtz H; Dobro J; Keslak JW; Cohen E; et al; R.A. Cooke Inst. of Allergy, St. Luke's/Roosevelt Hosp. Center,; New York, NY
The immunomodulatory effects of indomethacin (25 mg/day qid for 4 wk) were studied in 8 patients with acquired immune deficiency syndrome (AIDS)-related complex (ARC) and 8 patients meeting the Centers for Disease Control surveillance definition of AIDS. There was no significant effect of indomethacin treatment on mea
The Biology of the Interferon System 1986. Cantell K, Schellekens H, eds. Boston, Martinus Nijhoff Publishers, p. 355-62, 1987.. Unique Identifier : AIDSLINE ICDB/88638679
Fischl MA; Gorowski E; Koch G; Lucas LS; Richman S; Fletcher MA; No affiliation given
Sixty-four men (median age 31.0 yr; range 23-55 yr) with biopsy-proven Kaposi s sarcoma associated with acquired immunodeficiency syndrome (AIDS) were treated with either human lymphoblastoid interferon alone (IFN [Wellferon]: Stage I, II, or IIa disease) or IFN + vinblastine (VBL: Stage IIIb or IV disease). IFN was g
The Biology of the Interferon System 1986. Cantell K, Schellekens H, eds. Boston, Martinus Nijhoff Publishers, p. 423-7, 1987.. Unique Identifier : AIDSLINE ICDB/88638687
Chadha KC; Ambrus JL; Ikossi MG; Roswell Park Memorial Inst., Buffalo, NY
The natural human interferon (IFN) system is reviewed, including the IFN system in healthy adults, cancer patients, and patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC), and the modulation of IFN production capacity of WBCs. WBCs of cancer patients have a depressed capacity to syn
Cancer Risks. Strategies for Elimination. Bannasch P, ed. New York, Springer-Verlag, p. 181-9, 1987.. Unique Identifier : AIDSLINE ICDB/88638649
Deinhardt F; Max von Pettenkofer Institut fur Hygiene und Medizinische; Mikrobiologie der Ludwig-Maximilians-Universitat Munchen,; Pettenkoferstr. 9, D-8000 Munchen 2, FRG
Strategies for prevention of infection with oncogenic viruses are discussed, with emphasis on vaccination for hepatitis B virus (HBV). Topics include immunization against Epstein-Barr virus, public health measures and immunization against retroviruses, immunization against papovaviruses, and immunization against HBV.
Acquired immunodeficiency syndrome (AIDS) has recently received considerable media attention. Health care workers, including respiratory care practitioners, are concerned about the many medical and psychosocial implications of the disease. This article reviews the epidemiology and clinical features of AIDS. Health car
Boll Ist Sieroter Milan. 1987;66(2):101-5. Unique Identifier : AIDSLINE MED/88024452
Ripa S; Mignini F; Anichini M; Casprini P; Prenna M; Department Cellular Biology, University of Camerino.
208 assay for the research into anti-HTLV III antibodies and lymphocytes subsets were carried out on the same number of patients at risk. 11 homosexual man, 143 intravenous drug users (i.d.u.) and 3 children of drug addicts from hospitals in the Marche and Abruzzo and 51 haemophiliacs from hospital in Florence were ex
Oksenhendler E; Bierling P; Farcet JP; Rabian C; Seligmann M; Clauvel JP; Department of Clinical Immunopathology and Haematology, Hopital; Saint-Louis, Paris, France.
Thirty-seven patients belonging to the major AIDS-risk groups and with serum antibodies to the human immunodeficiency virus (HIV), were evaluated and treated between 1983 and 1986 because of profound chronic thrombocytopenia with clinical bleeding. Fifteen out of 26 patients achieved a significant response while on pr
van der Lelie J; Lange JM; Vos JJ; van Dalen CM; Danner SA; von dem Borne AE; Department of Haematology, University of Amsterdam, The; Netherlands.
In persons with AIDS or at risk from AIDS, autoantibodies against platelets and granulocytes were frequently detected. Platelet-bound immunoglobulins were demonstrated by immunofluorescence in all 16 patients with AIDS, in five out of seven patients with AIDS-related complex/persistent generalized lymphadenopathy (ARC
Leiderman IZ; Greenberg ML; Adelsberg BR; Siegal FP; Division of Clinical Immunology, Mount Sinai School of Medicine; (CUNY).
Patients infected with the human immunodeficiency virus (HIV) often present with neutropenia. To elucidate the mechanism(s) of this HIV-related neutropenia, we assessed the proliferative capacity of the granulocyte-macrophage progenitor cell (CFU-GM) from the bone marrow (BM) of 78 patients within the AIDS spectrum ma
Perkins HA; Samson S; Garner J; Echenberg D; Allen JR; Cowan M; Levy JA; Irwin Memorial Blood Bank, San Francisco, CA 94118.
Reported cases of acquired immunodeficiency syndrome (AIDS) in San Francisco as of March 31, 1986, include 92 individuals who had donated blood subsequent to 1978. Their donated blood components had been transfused into 406 different recipients. The current status of 336 of these recipients was ascertained as of April
Int J Epidemiol. 1987 Sep;16(3):462-5. Unique Identifier : AIDSLINE MED/88031882
Toukan AU; Schable CA; Department of Medicine, Jordan University Hospital, Amman.
Sera from 1124 Jordanian subjects were screened for HIV antibodies by enzyme immunoassay (EIA). The study population represented healthy rural and urban residents of Jordan as well as patients with hepatitis and their contacts, and patients with a variety of other diseases. Two patients with hepatitis had a positive t
Int J Epidemiol. 1987 Sep;16(3):482-4. Unique Identifier : AIDSLINE MED/88031886
Messiah A; Mary JY; Brunet JB; Rozenbaum W; Gentilini M; Valleron AJ; Bureau des Maladies Transmissibles, Direction Generale de la; Sante Ministere des Affaires Sociales et de l'Emploi, Paris,; France.
Kaplan JC; Crawford DC; Durno AG; Schooley RT; Infectious Disease Unit, Massachusetts General Hospital, Boston; 02114.
Human immunodeficiency virus (HIV), the etiological agent of the acquired immunodeficiency syndrome (AIDS), was treated with either Betadine (povidone-iodine) Solution or Betadine Surgical Scrub. HIV inactivation was analyzed using the viral reverse transcriptase assay or by observing the cytopathic effect produced in
Katsumoto T; Hattori N; Kurimura T; Department of Virology, Tottori University School of Medicine,; Yonago, Japan.
The budding process of human immunodeficiency virus (HIV), strain LAV, starts with the formation of a crescent electron-dense layer directly underneath the cell membrane of infected CCRF-CEM cells. After completion of the formation of the circle of inner dense layer, immature virions with an electron-lucent center are
Stevens LA; Muskin PR; Department of Consultation/Liaison Psychiatry,; Columbia-Presbyterian Medical Center, New York, New York 10032.
Educating the general population and health care workers about the acquired immunodeficiency syndrome (AIDS) is of paramount importance. There is a need to address the many fears and anxieties concerning this dreaded illness. Experience has shown that simple information-giving alone does little to allay the panic in t
Melzer SM; Weiner MA; Murphy RJ; Jaffe LR; Department of Pediatrics, Mount Sinai School of Medicine, New; York, New York.
Immunologically mediated thrombocytopenia has been reported as a manifestation of human T-lymphotropic virus type III (HTLV-III) infection and intravenous (IV) drug abuse. The case report describes thrombocytopenia in a bisexual adolescent male with antibody to the HTLV-III virus and a history of infrequent IV drug ab
Ng VL; Hadley WK; Fennell CL; Flores BM; Stamm WE; Department of Laboratory Medicine, San Francisco General; Hospital, University of California 94110.
A bisexual human immunodeficiency virus-seropositive male had successive bacteremias with Campylobacter cinaedi and Campylobacter fennelliae. Because final identification of both isolates was not completed until 1 month after the last admission of the patient, a novel and nonstandardized antimicrobial susceptibility t
Duvic M; Rapini R; Hoots WK; Mansell PW; University of Texas Health Science Center at Houston, Medical; School, M.D. Anderson Hospital and Tumor Institute, Department of; Dermatology 77030.
Persistent viral infections have been postulated to be trigger factors for the development of autoimmune disease. We report the development of vitiligo in four patients with human immunodeficiency virus (HIV)-related conditions and in one patient with hepatitis who later developed both psoriasis and acquired immunodef
Niimi K; Imataki T; Ono K; Matsuoka H; Miyata Y; Third Department of Anatomy, Okayama University Medical School,; Japan.
The topical organization of thalamic projections to the second and fourth somesthetic areas in the anterior ectosylvian gyrus of the cat has been studied using the technique of retrograde axonal transport of horseradish peroxidase. The projections of the posterolateral and posteromedial ventral nuclei (VPL, VPM) to th
J Immunol. 1987 Nov 1;139(9):2950-6. Unique Identifier : AIDSLINE MED/88034375
Zhou EM; Chanh TC; Dreesman GR; Kanda P; Kennedy RC; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, TX 78284.
Anti-idiotypic antibodies (anti-Id) to chimpanzee antibodies directed against a synthetic peptide corresponding to a native epitope associated with gp41 of human immunodeficiency virus (HIV) envelope glycoprotein were produced in rabbits. The peptide was analogous to amino acid sequences 735 to 752 from the human T ce
A nine-month-old female Jamaican infant presented with a history of severe failure to thrive, recurrent pneumonia and developmental delay. She was found to have hepatosplenomegaly, generalised lymphadenopathy and hypotonia. Investigations revealed polyclonal hypergammaglobulinaemia, cy
Iversen OJ; Engen S; Department of Microbiology, University of Trondheim, Norway.
Some central questions concerning the epidemiology of AIDS are addressed by statistical analyses. Applying standard maximum likelihood theory to reported cases of transfusion-associated AIDS in the US, the mean and standard deviation of incubation time for AIDS are estimated to be about 60 and 19 months, respectively.
Med Trop (Mars). 1987 Jul-Sep;47(3):287-91. Unique Identifier : AIDSLINE MED/88038191
Aubry P; Martet G; Parzy D; Service de sante des Armees, Marseille.
A.I.D.S. has revealed some parasitic, microbiotic, mycotic or viral diseases causing diarrhea or has given a revival of interest to them. So are Cryptosporidium, Isospora belli, Salmonella typhi murium, Cytomegalovirus. Some easy techniques lead to the diagnosis of some pathogenic agents, such as parasitologic diagnos
Med Trop (Mars). 1987 Jul-Sep;47(3):293-5. Unique Identifier : AIDSLINE MED/88038192
Gras C; Jeandel P; Cuisinier-Raynal JC; Aubry P; Institut de medecine tropicale du Service de sante des Armees,; Marseille.
The authors first point out the importance of A.I.D.S. in Africa; then they appreciate the risk of contamination for occasional traveller in Africa. They recall some epidemic features of tropical A.I.D.S., its originality suggesting some risk factors different from the ones faced in temperate countries. Importance of
Bigonzi F; Touboul JL; Fouret P; Denis M; Mayaud C; Akoun G; Centre de Pneumologie et de Reanimation respiratoire, Hopital; Tenon, Paris.
We report the case of a male patient with AIDS who had been hospitalized for various opportunistic infections, from which he recovered, and was readmitted on account of a round opacity in the lower lobe of his right lung. There was no evidence of extrapulmonary pathology. Transtracheal aspiration, alveolar lavage and
Schweiz Med Wochenschr. 1987 Aug 29;117(35):1297-301. Unique Identifier : AIDSLINE MED/88042650
Haegi V; St. Gallische Hohenklinik, Walenstadtberg.
A 27-year old female HIV-positive patient developed septic tuberculosis, with mycobacterium tuberculosis typus humanus repeatedly found not only in sputum, bronchial secretion, blood and faeces but also in biopsy material from the liver. Although standard therapy with Pyrazinamid, Rifampicin and INH had to be replaced
Scott Med J. 1987 Aug;32(4):109-11. Unique Identifier : AIDSLINE MED/88042767
Lowe GD; West of Scotland Haemophilia Reference Centre.
Between 1979 and 1984, many haemophiliacs in the UK were exposed to the human immunodeficiency virus (HIV) by transfusion of blood products, in particular clotting factor concentrates, especially those imported from the USA. In the UK 1025 haemophiliacs are HIV-antibody-positive, of whom 75 are in Scotland. Thirty-one
Scott Med J. 1987 Aug;32(4):114-6. Unique Identifier : AIDSLINE MED/88042770
Wilkie PA; West of Scotland Haemophilia Reference Centre.
HIV infection and AIDS have focused attention on counselling as a major and integral part of the total clinical care of HIV seropositive and AIDS patients. There is, as yet, no cure for HIV infection and treatment is of the symptoms as they appear. This combined with the lack of knowledge of how the infection may prog
Scott Med J. 1987 Aug;32(4):121-2. Unique Identifier : AIDSLINE MED/88042773
Forsyth JS; Sharp RA; Ghosh S; Department of Paediatrics, Ninewells Hospital and Medical School,; Dundee.
A one-year-old child who presented with thrombocytopaenia was found to be HIV positive and has now developed persistent generalised lymphadenopathy (PGL).
Kaplan MS; Wechsler M; Benson MC; Department of Urology, Columbia University, New York, New York.
A retrospective analysis of 60 patients with Acquired Immune Deficiency Syndrome (AIDS) seen between 1981-1985 was performed to determine the genitourinary manifestations of this disease. Twenty-two per cent were found to have significant proteinuria, while 7 per cent had nephrotic syndrome which was associated with a
Wien Med Wochenschr. 1987 Aug 15;137(14-15):326-9. Unique Identifier : AIDSLINE MED/88044798
Futter H; Pathologischen Institut, Krankenhauses St. Polten.
Atypical mycobacteria may cause pulmonary diseases - similar to tuberculosis - as well as infections of the lymph nodes, the skin and other organs. But only if several cultures from sputum or biopsy specimen have been positive and Mycobacterium tuberculosis has been excluded, these species can be noted as the pathogen
Pokrovskii VV; Iankina ZK; Toporovskii LM; Ryvkina VG; Pokrovskii VI
The screening covering 5,155 residents of Moscow and 6,412 foreign students revealed the presence of antibodies to the virus, causing immunodeficiency in man, in 20 students from African countries. The antibodies were detected by means of the immune blotting assay. The problem of the possibility of the heterosexual tr
Am Fam Physician. 1987 Oct;36(4):201-4. Unique Identifier : AIDSLINE MED/88046503
Fischer MC; Agger WA; Gundersen Clinic, La Crosse, Wisconsin.
In the United States , the four groups at high risk of cryptosporidiosis are animal handlers, foreign travelers, children in day care centers and immunocompromised patients, including those with acquired immunodeficiency syndrome. In immunocompetent patients, the sporadic diarrheal illn
Am Fam Physician. 1987 Oct;36(4):233-5. Unique Identifier : AIDSLINE MED/88046507
Wilkerson MG; Jordan WP; Kerkering TM; Medical College of Virginia, Richmond.
Herpes zoster has recently been reported in young patients with risk factors for AIDS. In high-risk patients under age 55, herpes may be the first manifestation of AIDS or AIDS-related complex. Dissemination of zoster does not appear to be greatly increased in this group, but corticosteroid therapy should be withheld.
Am J Hematol. 1987 Nov;26(3):273-7. Unique Identifier : AIDSLINE MED/88046757
Castro O; Alarif L; Saxinger C; Frederick W; Department of Medicine, Howard University College of Medicine,; Washington, D.C.
A woman with sickle cell-hemoglobin C disease developed the acquired immunodeficiency syndrome (AIDS), possibly as the result of blood transfusions administered 4 years earlier. Three months after subsequent transfusions, she had excess HLA-A and DR antigens (triplets) on her circulating lymphocytes. Three of her firs
Guerra IL; Abraham AA; Kimmel PL; Sabnis SG; Antonovych TT; George Washington University Medical Center, Washington, DC; 20037.
Several renal diseases have been reported to complicate both hepatitis B and human immunodeficiency virus infection. Establishing the exact renal diagnosis in patients with multiple viral infections requires renal biopsy. Exposure to human immunodeficiency virus may not determine renal histopathology. Although exact p
Am J Med. 1987 Nov;83(5):813-6. Unique Identifier : AIDSLINE MED/88046889
Hollander H; Stringari S; School of Medicine, University of California, San Francisco; 94143.
Fourteen patients infected with human immunodeficiency virus (HIV) had a lymphocytic pleocytosis unexplained by secondary pathogens or neoplasms. Three men had prior diagnoses of Kaposi s sarcoma; none had acquired immune deficiency syndrome-defining opportunistic infections. Two patterns of illness were observed. Sev
Am J Med. 1987 Nov;83(5):945-8. Unique Identifier : AIDSLINE MED/88046909
Maayan S; Wormser GP; Widerhorn J; Sy ER; Kim YH; Ernst JA; Department of Medicine, Bronx Lebanon Hospital, New York.
Severe infections with Strongyloides stercoralis occur in immunocompromised patients. Strongyloides hyperinfection syndrome complicated by gram-negative bacteremia and meningitis in a bisexual man with the acquired immune deficiency syndrome (AIDS) is described. Increased awareness of this infection, which may also be
Kissner DG; Department of Internal Medicine, Hutzel Hospital, Detroit, MI; 48201.
The incidence of tuberculosis in the United States appears to be rising, most likely because of the introduction of the human immunodeficiency virus, and other factors such as outbreaks among the homeless and immigration of infected people from other countries. Because diagnosis and tr
Clemens R; Weidmann E; Merkle W; Bock HL; Mauler R; Hilfenhaus J; Clinical Research Department of Behringwerke AG, Marburg/Lahn,; Fed. Rep. of Germany.
Blood derived products carry the risk of virus transmission, especially for the hepatitis B virus (HBV), non-A/non-B virus(es) (NANBV) and human immunodeficiency virus (HIV). The precautionary measures for guaranteeing the virus safety of the pasteurized antithrombin III concentrate Kybernin HS/P are described and the
Cancer. 1987 Nov 15;60(10):2454-8. Unique Identifier : AIDSLINE MED/88026626
Lowenthal DA; Filippa DA; Richardson ME; Bertoni M; Straus DJ; Department of Medicine, Memorial Sloan-Kettering Cancer Center,; New York, NY 10021.
In recent years the literature has described a highly lethal multicentric variant of classic Castleman s disease (CD) with similar hyperplastic angio-follicular morphologic features. A 44-year-old man who was not known to be part of any established high-risk group for the acquired immune deficiency syndrome (AIDS) pre
Since 1985 all donor blood in the Federal Republic of Germany (FRG) and West Berlin (WB) have been routinely tested for HIV antibodies. The blood donor services of the German and Bavarian Red Cross have pooled their anti-HIV test data for the first year of operation (July 1985-Jun
Bjorck L; Blomberg J; Department of Medical Microbiology, University of Lund, Sweden.
Protein G is a cell wall protein of group C and G streptococci which binds human IgG antibodies of all four subclasses with high affinity. This property of the molecule was utilized to develop a sensitive Western blot assay to detect antibodies against HIV proteins in patient sera.
Hellings JA; Theunissen H; Keur W; Siebelink-Liauw A; Organon Scientific Development Group, Diagnostics Research; Laboratories, Oss, The Netherlands.
First generation ELISA screening assays for antibodies to HTLV-III (HIV) generated between 0.1 and 1.0% false positive results. Western blot analysis in specialized reference centers is almost uniformly used as a method to confirm the specificity of the ELISA results. Yet, the high cost, time delay and lack of standar
Goudsmit J; Lange JM; Krone WJ; Teunissen MB; Epstein LG; Danner SA; van den Berg H; Breederveld C; Smit L; Bakker M; et al; Virology Department, University of Amsterdam, The Netherlands.
Human immunodeficiency virus (HIV) is lymphotropic and neurotropic. In vivo clinical and immunological abnormalities develop in a large proportion of long-term HIV antibody seropositive persons. Different stages of HIV infection are marked by expression of HIV genes, production of HIV antibodies, formation of antigen/
Nelson LP; Album MM; Department of Pediatric Surgery, University of Pennsylvania; School of Medicine.
Surgeon General Koop charged the group attending a conference workshop at the Children s Hospital of Philadelphia with making recommendations to help set national policy regarding AIDS.
56 cases of pregnant women with a positive HIV serology were reported in 20 months at the Maternity of the Nice Hospital Center. In 10 cases, there were clinical signs of the disease (9 ARC-Syndrome, one case of AIDS). The predisposing factor was most of the time drug addiction, 53 cases (94.5%) and one case occurred
Krichbaum-Stenger K; Poiesz BJ; Keller P; Ehrlich G; Gavalchin J; Davis BH; Moore JL; SUNY, Department of Medicine, Syracuse 13210.
In this report, we describe a flow cytometric analysis of HTLV-I specific binding to fresh and cultured cells on a single cell basis. This assay uses rhodamine hydrocarbon tagged, purified HTLV-I virions according to the procedure originally described for avian retroviruses. Successful HTLV-I transmission was detected
Israel HL; Gottlieb JE; Schulman ES; Department of Medicine, Jefferson Medical College, Thomas; Jefferson University, Philadelphia 19107.
Three patients encountered in a single month had insidious development of atypical respiratory or systemic symptoms and were found to be hypoxemic. All had normal chest roentgenograms and were perplexing problems in diagnosis. On initial presentation, none had evidence of pulmonary infection or recognized clinical or
Blomback M; Kjellman H; Schulman S; Egberg N; Bottiger B; Wiechel B; Department of Clinical Chemistry and Blood Coagulation,; Karolinska Hospital, Stockholm.
Immunoglobulins and aminotransferases were followed in 66 haemophilia patients and 13 von Willebrand patients over a six-year period. The results were correlated to HIV serology and lymphocyte subsets. Elevated IgG levels were found in 29/53 patients with haemophilia A, 2/13 with haemophilia B and in 0/13 with von Wil
Mottice S; Matsumiya S; Reimer L; Department of Pathology, Salt Lake City Veterans Administration; Medical Center, UT 84148.
Guidelines for the indications for use, requirements for consent, and mechanisms for reporting of serologic tests for human immunodeficiency virus (HIV) infection are not standardized. In trying to establish such guidelines for our hospital, we surveyed all Veterans Administration Medical Centers regarding their curre
J Immunol. 1987 Nov 1;139(9):2929-35. Unique Identifier : AIDSLINE MED/88034371
Teeuwsen VJ; Logtenberg T; Siebelink KH; Lange JM; Goudsmit J; Uytdehaag FG; Osterhaus AD; Department of Immunobiology, National Institute of Public Health; and Environmental Hygiene, Bilthoven, The Netherlands.
Five asymptomatic human immunodeficiency virus (HIV)-seropositive male homosexuals were immunized with the recall antigens tetanus toxoid (TT) and the three types of poliovirus present in diphtheria, tetanus, and polio vaccine. Four weeks after immunization, the in vivo response to booster immunization, the in vitro p
J Med Chem. 1987 Nov;30(11):2131-7. Unique Identifier : AIDSLINE MED/88035943
Herdewijn P; Pauwels R; Baba M; Balzarini J; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
A systematic synthesis was undertaken of 2 ,3 -dideoxyadenosine analogues with either an azido, fluorine, or hydroxyl group substituted in the up or down position of C-2 or C-3 of the sugar moiety. The compounds were evaluated against the cytopathogenicity of human immunodeficiency virus (HIV) for MT-4 cells. The four
Proc Natl Acad Sci U S A. 1987 Nov;84(21):7706-10. Unique Identifier : AIDSLINE MED/88041172
Matsukura M; Shinozuka K; Zon G; Mitsuya H; Reitz M; Cohen JS; Broder S; Clinical Oncology Program, National Cancer Institute, Bethesda,; MD 20892.
Nuclease-resistant phosphorothioate analogs of certain oligodeoxynucleotides have been tested in vitro as antiviral agents against human immunodeficiency virus (HIV) in human T cells. Phosphorothioate analogs complementary to HIV sequences, as well as noncomplementary analogs including homooligomers, exhibited potent
Ter Arkh. 1987;59(7):35-9. Unique Identifier : AIDSLINE MED/88043200
Pokrovskii VV; Iankina ZK; Pokrovskii VI; Potekaev NS; Etkin AF
Of 20 examined Africans who were seropositive to HIV in the Western Blot technique, the syndrome of acquired immunodeficiency was found in 2, generalized lymphoadenopathy in 17; in one patient infection was asymptomatic. A decrease in the T-helper/T-suppressor ratio was noted in all the examinees, in 88% of the patien
A study was made of the level of anti-HTLV-111 using an enzyme immunoassay (Emzygnost-anti-HTLV-111) in 75 donors and 143 patients with various diseases including SLE (57), rheumatoid arthritis (9), Sjogren s disease (3), Bekhterev s disease (2), polymyositis (2), dilatation cardiomyopathy (30), and acute lymphocytic
Brenner M; Ognibene FP; Lack EE; Simmons JT; Suffredini AF; Lane HC; Fauci AS; Parrillo JE; Shelhamer JH; Masur H; Critical Care Medicine Department, National Institutes of Allergy; and Infectious Diseases, Bethesda, Maryland.
To assess determinants of prognosis for 43 patients with the acquired immunodeficiency syndrome (AIDS) and Pneumocystis carinii pneumonia, objective clinical and histopathologic characteristics were analyzed for acute and long-term prognostic significance. Severe abnormalities on initial chest radiographs and alveolar
Reynolds HY; Pulmonary Section, Yale University School of Medicine, New Haven,; Connecticut.
Host defense mechanisms spaced along the respiratory tree and in the alveolar spaces effectively remove or contend with micro-organisms that enter the airways, so serious lung infections occur rarely in healthy people. Special circumstances, such as virgin exposure to a virulent microbe or a large innoculum of a patho
Dtsch Med Wochenschr. 1987 Oct 30;112(44):1687-93. Unique Identifier : AIDSLINE MED/88029078
Schulte C; Meurer M; Braun-Falco O; Froschl M; Ring J; Riethmuller G; Gurtler L; Dermatologische Klinik und Poliklinik, Universitat Munchen.
Since 1985, a total of 4281 patients at the Department of Dermatology, University of Munich, were tested for HIV-1 antibodies. Using the ELISA test, 273 were found to be positive, of whom 198 were examined clinically. At the time of the first serological test, 76 of these 198 patients (38.4%) had no clinical symptoms,
Apperley JF; Rice SJ; Hewitt P; Rombos Y; Barbara J; Gabriel FG; Goldman JM; Royal Postgraduate Medical School, London, U.K.
A 30-yr-old man with chronic granulocytic leukaemia received a bone marrow transplant from his histocompatible sister in December 1982. His post-transplant course was complicated by Grade III graft-versus-host disease and multiple infectious episodes until his death from pneumonia on d + 190. He was later found to be
Sudden and unexpected death and violent death of persons with a high risk of acquiring HIV-infections, especially homosexual males and intravenous drug abusers, have to be investigated by forensic autopsies. Therefore every forensic pathologist has to be aware of this infection and should try to make the proper diagno
Aceti A; Titti F; Verani P; Butto S; Pennica A; Sebastiani A; Rossi GB; Department of Tropical and Infectious Diseases, La Sapienza; University, Rome, Italy.
We describe a new immunoassay, time-resolved fluoroimmunoassay (TR-FIA), for detection of anti-HIV antibodies in human sera. This method is based on the use of a crude virus preparation coated on a polystyrene microtitre plate and of a swine anti-human IgG labelled with a rare earth metal, europium, as fluorescent lab
Piot P; Colebunders R; Laga M; Ndinya-Achola JO; van der Groen G; Plummer FA; Department of Microbiology, Institute of Tropical Medicine,; Antwerp, Belgium.
AIDS and HIV infection are now endemic in many parts of Africa. The infection is mainly transmitted by heterosexual activity, as illustrated by a 1:1 female to male case ratio and high HIV seroprevalence rates in people at risk for sexually transmitted diseases and female prostitutes. Transmission by blood transfusion
van der Groen G; Vercauteren G; Piot P; Institute of Tropical Medicine, Antwerp, Belgium.
The enzyme-linked immunosorbent assay (ELISA) is currently being used as a sensitive screening test for HIV antibody. The immunoblot assay (IBA) and indirect immunofluorescence (IF) techniques are two recommended confirmation tests for EIA-positive sera. An indirect IF test has been developed by various laboratories u
Zolla-Pazner S; Pinter A; Mizuma H; Laboratory Service, New York Veterans Administration Medical; Center, NY 10016.
While prevention of infection with the human immunodeficiency virus (HIV) using prophylactic immunization and treatment with anti-viral drugs would appear to be the methods of choice for the prevention and treatment of this infection, neither safe and effective vaccines nor anti-viral agents have yet been developed. A
Ferdinand FJ; Dorner F; Kurth R; Paul-Ehrlich-Institut, Bundesamt fur Sera und Impfstoffe,; Frankfurt, F.R.G.
Human immunodeficiency virus type 1 (HIV-1) may enter the blood stream as free virus or via infected lymphocytes, which poses problems for vaccine development. The classical vaccine designs, attenuated, inactivated, or subunit vaccine will be discussed with regard to HIV. Development of a recombinant subunit vaccine a
Gill VJ; Evans G; Stock F; Parrillo JE; Masur H; Kovacs JA; Department of Clinical Pathology, National Institutes of Health,; Bethesda, Maryland 20892.
A combination of three monoclonal antibodies, two prepared against human and one against rat Pneumocystis carinii, was used in an indirect fluorescent-antibody stain (IFA) to diagnose P. carinii in both bronchoalveolar lavage and lung biopsy specimens. This combination of monoclonal antibodies was specific for P. cari
Blumberg RS; Hartshorn KL; Ardman B; Kaplan JC; Paradis T; Vogt M; Hirsch MS; Schooley RT; Infectious Disease Unit, Massachusetts General Hospital, Boston; 02114.
The detection of human immunodeficiency virus (HIV)-associated antigens was simplified by the application of dot immunobinding on a nitrocellulose matrix. Antigens were detected by applying the polyethylene glycol-precipitated supernatants of experimentally infected cultures directly onto nitrocellulose strips and seq
Schmidt G; Amiraian K; Frey H; Stevens RW; Berns DS; Wadsworth Center for Laboratories and Research, New York State; Department of Health, Albany 12201.
Western blot assays for antibodies directed against components of human immunodeficiency virus (HIV) associated with acquired immunodeficiency syndrome (AIDS) were examined with a densitometer and integrator. Antibody responses to seven HIV proteins were determined from the areas under the peaks of bands on blots from
Hu SI; Kosowski SG; Schaaf KF; Oncogen System Corporation, Seattle, Washington 98121.
The envelope gene of human immunodeficiency virus was inserted into the genome of an insect virus vector (Autographa californica nuclear polyhedrosis virus). Upon infection of tissue culture cells, this recombinant virus produced immunoreactive polypeptides related to the envelope glycoproteins of human immunodeficien
JAMA. 1987 Nov 20;258(19):2701-3. Unique Identifier : AIDSLINE MED/88036367
Landesman S; Minkoff H; Holman S; McCalla S; Sijin O; Department of Medicine, State University of New York Health; Science Center, Brooklyn 11203.
Although perinatal transmission of the human immunodeficiency virus (HIV) is well documented, seroprevalence rates of HIV in populations of women of reproductive age have not yet been reported. To determine the seroprevalence of HIV in childbearing women from a population with a high incidence of acquired immunodefici
JAMA. 1987 Nov 20;258(19):2714-7. Unique Identifier : AIDSLINE MED/88036370
Minkoff HL; Department of Obstetrics and Gynecology, State University of New; York Health Science Center, Brooklyn 11203.
The Centers for Disease Control and the American College of Obstetricians and Gynecologists have recommended that pregnant women who are at increased risk for acquired immunodeficiency syndrome be tested for antibodies to human immunodeficiency virus. When this recommendation is implemented, some clinicians who undoub
Retroviruses (mainly H.I.V. 1 and H.I.V. 2) are now largely spread over in Central Africa and Caribbean Islands, particularly in large cities. Their transmission is essentially horizontal and mainly sexual. As a matter of fact, sexual transmission is responsible in about 80% of the cases, leaving only a small percenta
Cantani A; Abteilung fur Allergie und klinische Immunologie, Kinderklinik; der Universitat La Sapienza, Roma.
The spectrum of the acquired immunodeficiency syndrome (AIDS) has broadened to include children. A review of the literature revealed 452 pediatric patients with AIDS. Based on these data, relevant and practically oriented information is given concerning epidemiology, clinical features and laboratory findings, diagnosi
Wilhelmus KR; Farge EJ; Lions Eyes of Texas Eye Bank, Baylor College of Medicine,; Houston, Tex.
Because of the risk of transmitting the acquired immune deficiency syndrome through corneal transplantation, health officials have recommended donor screening. We prospectively studied the seropositivity rate for human immunodeficiency virus infection among ocular tissue donors at our eye bank during 1986. Of 1,517 co
Petersen HD; Lindhardt BO; Nyarango PM; Bowry TR; Chemtai AK; Krogsgaard K; Bunyasi A; Department of Infectious Diseases, Rigshospitalet, University of; Copenhagen, Denmark.
In order to describe the prevalence of HIV antibodies and AIDS in West Kenya , serological tests, including ELISA, and in some cases immunoblotting, were performed on whole blood collected on filter paper from 603 Kenyans. Serum samples from 55 of these persons underwent the same exa
Schweiz Med Wochenschr. 1987 Aug 29;117(35):1289-96. Unique Identifier : AIDSLINE MED/88042649
Dietrich PY; Bille J; Fontolliet C; Regamey C; Service de medecine interne, Hopital cantonal, Fribourg.
Very commonly encountered in the United States , histoplasmosis is rare in Europe, where only 27 patients have so far been infected by this mycosis. In Africa, two varieties of histoplasmosis have been observed: those due to H. capsulatum and H. duboisii. Histoplasmosis due to H. capsul
Scott Med J. 1987 Aug;32(4):101-7. Unique Identifier : AIDSLINE MED/88042765
Kennedy DH; Department of Infectious Diseases, Ruchill Hospital, Glasgow.
The wide clinical spectrum of HIV infection is reflected in the new CDC classification. Presentations range from acute infection, asymptomatic carriage and persistent lymphadenopathy through constitutional upset and neurological disease to the opportunistic infections and cancers of AIDS. AIDS is an enigmatic disease
Science. 1987 Nov 6;238(4828):800-2. Unique Identifier : AIDSLINE MED/88042815
Folks TM; Justement J; Kinter A; Dinarello CA; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892.
A model system for cytokine-induced up-regulation of human immunodeficiency virus type 1 (HIV-1) expression in chronically infected promonocyte clones was established. The parent promonocyte cell line U937 was chronically infected with HIV-1 and from this line a clone, U1, was derived. U1 showed minimal constitutive e
Zuckerman AJ; Department of Medical Microbiology, London School of Hygiene and; Tropical Medicine, UK.
Recombinant hepatitis B vaccines produced in yeast and in mammalian cells are the first of future vaccines against this important public health problem. Hybrid virus vaccines and the use of baculoviruses for expression of hepatitis B antigens in insect cell cultures will follow shortly and chemically synthetic vaccine
Kalangu K; Waltregny A; Service de Neurochirurgie, Universite de Liege.
Central nervous system (CNS) complications are currently described in patients with Acquired Immuno-Deficiency Syndrome (AIDS). CT-scan imaging is helpful in the description of the lesions. However, by CT-criteria alone, it is not possible to reliably distinguish toxoplasmosis from other CNS infections and from a prim
Houn HY; Pappas AA; Walker EM Jr; Department of Pathology, University of Arkansas for Medical; Sciences, Little Rock.
Two laboratory tests are currently used to detect the human immunodeficiency virus (HIV) specific antibodies that are produced when an individual has been infected by the virus at some time. These include the enzyme-linked immunosorbent assay (ELISA) as the screening test and the Western blot (WB) as the confirmatory
Ito M; Baba M; Sato A; Pauwels R; De Clercq E; Shigeta S; Department of Bacteriology, Fukushima Medical College, Japan.
The polyanionic substances dextran sulfate and heparin were investigated for their antiviral effect on the human immunodeficiency virus (HIV) in vitro. Dextran sulfate and heparin effected a 50% reduction in the cytopathogenicity of HIV for MT-4 cells at a concentration of 4.7 and 7.5 micrograms/ml, respectively. In M
Linder J; Department of Pathology and Microbiology, University of Nebraska; Medical Center, Omaha 68105-1065.
The microenvironment within the thymus gland and various thymic hormones facilitates the maturation of prothymocytes to functional T lymphocytes. Abnormal thymic morphology is a hallmark feature of several primary and secondary immunodeficiencies. Thymus glands from patients with the acquired immunodeficiency syndrome
Biochem Biophys Res Commun. 1987 Oct 14;148(1):78-85. Unique Identifier : AIDSLINE MED/88049711
Matthes E; Lehmann C; Scholz D; von Janta-Lipinski M; Gaertner K; Rosenthal HA; Langen P; Central Institute of Molecular Biology, Academy of Sciences of; the GDR, Berlin-Buch.
The sugar-modified dTTP analogues 2 ,3 -didehydro-2 ,3 -dideoxy-thymidine 5 -triphosphate (ddeTTP), 2 ,3 -dideoxythymidine 5 -triphosphate (ddTTP), 3 -fluorothymidine 5 -triphosphate (FdTTP), and 3 -azidothymidine 5 -triphosphate (N3dTTP) are demonstrated to be very effective and selective inhibitors of the HIV-associ
Biochem Pharmacol. 1987 Nov 1;36(21):3757-61. Unique Identifier : AIDSLINE MED/88049783
Harrington JA; Miller WH; Spector T; Burroughs Wellcome Co., Wellcome Research Laboratories, Research; Triangle Park, NC 27709.
The 5 -mono-, di- and triphosphate derivatives (N3dTMP, N3dTDP and N3dTTP respectively) of 3 -azidothymidine (N3dThd), a new drug for the treatment of the acquired immune deficiency syndrome (AIDS), were synthesized. The abilities of these analog nucleotides to mimic the effector properties of the corresponding thymid
Takase T; Rotblat F; Goodall AH; Kernoff PB; Middleton S; Chand S; Denson KW; Austen DE; Tuddenham EG; Academic Department of Haematology, Royal Free Hospital School of; Medicine, London.
Factor VIII deficient plasma was made from pooled, HIV antibody and hepatitis B antigen screened, normal human plasma by cryoprecipitation and immuno-depletion, using three different monoclonal antibodies bound to Sepharose columns, in series. These monoclonal antibodies are specific respectively for von Willebrand fa
Br Med J (Clin Res Ed). 1987 Sep 5;295(6598):567-9. Unique Identifier : AIDSLINE MED/88026200
Pedersen C; Nielsen CM; Vestergaard BF; Gerstoft J; Krogsgaard K; Nielsen JO; Department of Infectious Diseases, Hvidovre Hospital, Copenhagen,; Denmark.
A total of 276 sequential serum samples from 34 men with antibodies to the human immunodeficiency virus (HIV) followed up for two to seven years were analysed for HIV antigen and antibodies to the viral core and envelope proteins. Results were correlated with clinical outcome and CD4 T lymphocyte count. Both antigenae
Br Med J (Clin Res Ed). 1987 Sep 5;295(6598):569-72. Unique Identifier : AIDSLINE MED/88026201
de Wolf F; Goudsmit J; Paul DA; Lange JM; Hooijkaas C; Schellekens P; Coutinho RA; van der Noordaa J; Department of Virology, University of Amsterdam.
One hundred and ninety eight men seropositive for human immunodeficiency virus (HIV) antibody and 58 HIV antibody seroconverters were studied for an average of 19.3 (SEM 0.5) months to assess the relation between HIV antigenaemia and the risk of developing the acquired immune deficiency syndrome (AIDS) and AIDS relate
Roberts RB; Laskin OL; Laurence J; Scavuzzo D; Murray HW; Kim YT; Connor JD; Division of Infectious Diseases, Cornell University Medical; College, New York, NY 10021.
Ribavirin was administered orally in escalating doses for 2 or 4 weeks to 15 symptom-free, human immunodeficiency virus seropositive homosexual men with generalized lymphadenopathy. Reverse transcriptase activity was inhibited during therapy when steady-state plasma concentrations were greater than 6 mumol/L. These co
Cuthbertson B; Perry RJ; Foster PR; Reid KG; Crawford RJ; Yap PL; Scottish National Blood Transfusion Service, Protein; Fractionation Centre, Edinburgh.
Human immunoglobulin for intravenous (IV) use has an established safety record with regard to transmission of hepatitis B virus. The bulk of available evidence also suggests that the human immunodeficiency virus (HIV) is not transmitted by IV immunoglobulin. There has been one report, however, of isolation of HIV from
Kuntz AA; Gelderblom HR; Winkel T; Reichart PA; Department of Oral Surgery, Free University of Berlin, West; Germany.
Ten biopsies of oral Kaposi s sarcoma were examined histologically and ultrastructurally. Histologically, early and late tumor stages could be differentiated. On the ultrastructural level, endothelial-like and spindle-shaped tumor cells were revealed. Tumor cells associated with vessel-like spaces showed partly interr
Roy G; Rojo N; Leyva-Cobian F; Department of Immunology, Centro Ramon y Cajal, Madrid, Spain.
The expression of Class II histocompatibility antigens (HLA-DR and HLA-DQ), leukocyte function associated antigen (LFA-1) and complement receptor type 3 (CR3) on peripheral blood monocytes and alveolar macrophages (M phi) from patients with acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC) and
Nature. 1987 Nov 19-25;330(6145):259-62. Unique Identifier : AIDSLINE MED/88039137
Flexner C; Hugin A; Moss B; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892.
Recombinant vaccinia viruses have been proposed as live vaccines against a variety of infectious diseases, including AIDS (acquired immune deficiency syndrome). Objections have been concerned primarily with side effects of the vaccinia virus vector itself. Recently it has been shown that inactivation of the vaccinia v
Nature. 1987 Nov 19-25;330(6145):266-9. Unique Identifier : AIDSLINE MED/88039140
Guy B; Kieny MP; Riviere Y; Le Peuch C; Dott K; Girard M; Montagnier L; Lecocq JP; Transgene S.A., Strasbourg, France.
Apart from the retroviral gag, pol and env the HIV genome contains the F (3 orf) gene which encodes a polypeptide of 206 amino acids which is myristylated at the N-terminal and whose function is unknown. We have expressed the F gene in Escherichia coli and from a recombinant vaccinia virus, VVTGfHIV. The F-protein pr
Patients with terminal renal failure quite frequently receive blood transfusions on renal replacement therapy; therefore they are at increased risk of infection with human immunodeficiency virus (HIV). We investigated sera from 380 patients on haemodialysis or with a renal transplant for anti-HIV, using commercially a
Delacretaz F; Perey L; Schmidt PM; Chave JP; Costa J; Institut de Pathologie, Centre Hospitalier Universitaire Vaudois,; Lausanne, Switzerland.
The clinical and haematological findings in 18 patients with human immunodeficiency virus (HIV) infection were correlated with the histological features of plastic embedded bone marrow biopsies. Fifteen patients presented with peripheral cytopaenia of one or several cell lines. Twelve (66%) of the 18 patients exhibite
Am J Med. 1987 Oct 23;83(4A):4-9. Unique Identifier : AIDSLINE MED/88046872
Kurtzberg J; Friedman HS; Chaffee S; Falletta JM; Kinney TR; Kurlander R; Matthews TJ; Schwartz RS; Department of Pediatrics, Duke University Medical Center, Durham,; North Carolina 27710.
Sixteen pediatric patients diagnosed with a variety of autoimmune-mediated hematocytopenias were treated with one to 50 courses of intravenous gamma globulin (IVIG), pH 4.25, over the course of one to 30 months. Thirteen patients had immune thrombocytopenic purpura (ITP), two had autoimmune neutropenia, and one had au
Am J Med. 1987 Oct 23;83(4A):46-51. Unique Identifier : AIDSLINE MED/88046873
Schwartz RS; Division of Clinical Research, Cutter Biological, Miles Inc.,; Berkeley, California 94710.
Immune serum globulin has been available for approximately 40 years. Although this substance represented a major advance in the treatment of patients with agammaglobulinemia and hypogammaglobulinemia, it has a number of major limitations that restrict its clinical utility. These include the need for intramuscular admi
Tsang PH; Sei Y; Bekesi JG; Department of Neoplastic Diseases, Mount Sinai School of; Medicine, New York, New York 10029.
Peripheral blood leukocytes from ARC and AIDS patients were analyzed following phytohemagglutinin- and pokeweed mitogen-induced lymphocyte transformation by dual-color flow cytometry using monoclonal antibodies that identify developmental (HLA-DR) and functional (Leu8) subsets of T cells and monocytes. Significant dec
Atchison KA; Dolan TA; Meetz HK; UCLA School of Dentistry 90024-1668.
A random sample of 396 general dentists, oral surgeons, and periodontists in Los Angeles was interviewed in fall 1986. The purpose was to determine their experience in treating patients infected with HIV, factors associated with their knowledge about signs and symptoms of AIDS, and their sources of information regardi
Andrews CA; Sullivan JL; Brettler DB; Brewster FE; Forsberg AD; Scesney S; Levine PH; Department of Pediatrics, University of Massachusetts Medical; School, Worcester.
As part of a prospective study of human immunodeficiency virus (HIV) infection in hemophilia, peripheral blood mononuclear cells (PBMs) from 72 individuals without acquired immune deficiency syndrome (AIDS) or AIDS-related complex (ARC) were cultured for virus. HIV was isolated from PBMs from 16 (24%) of 66 patients w
26 homosexual men with antibodies to HIV and generalized lymphadenopathy were examined between 1982 and 1984. Lymphadenopathy was accompanied by clinical symptoms such as fever, diarrhoea and weight loss (50%), moderate leukopenia (15%), lymphocytosis (50%), hypoergy to intraepidermal skin test with recall-antigens (1
Nature. 1987 Nov 5-11;330(6143):74-7. Unique Identifier : AIDSLINE MED/88039097
Gruters RA; Neefjes JJ; Tersmette M; de Goede RE; Tulp A; Huisman HG; Miedema F; Ploegh HL; Central Laboratory, Netherlands Red Cross Blood Transfusion; Service, University of Amsterdam.
Human immunodeficiency virus (HIV), the causative agent of AIDS, infects human lymphocytes and monocytes. An interaction between the viral envelope gp 120 and CD4 protein is required to initiate an infectious cycle. HIV infection in vitro induces syncytium formation by cell-to-cell fusion; this aspect of viral cytopat
Proc Natl Acad Sci U S A. 1987 Oct;84(20):7270-4. Unique Identifier : AIDSLINE MED/88041089
Reibnegger G; Fuchs D; Hausen A; Werner ER; Dierich MP; Wachter H; Institute for Medicinal Chemistry and Biochemistry, University of; Innsbruck, Austria.
The breakdown of the immune system induced by the human immunodeficiency virus might be due to the active immune destruction of human immunodeficiency virus-infected helper T lymphocytes expressing viral antigens. By numerical simulation, we have studied possible consequences that a hypothetical immunodeficiency virus
Biochem Biophys Res Commun. 1987 Oct 14;148(1):206-10. Unique Identifier : AIDSLINE MED/88049658
Sunkara PS; Bowlin TL; Liu PS; Sjoerdsma A; Merrell Dow Research Institute, Cincinnati, OH 45215.
The objective of this study was to investigate the antiretroviral activity of specific inhibitors of glycosidases and mannosidases that are involved in N-linked oligosaccharide processing of glycoproteins. Castanospermine and 1-deoxynojirimycin, potent inhibitors of glucosidases I and II, showed significant activity a
Limentani SA; Furie BC; Poiesz BJ; Montagna R; Wells K; Furie B; Department of Medicine, New England Medical Center, Boston, MA.
Immunoaffinity chromatography using conformation-specific antibodies yields pure factor IX from human plasma in a single rapid, facile purification step. We evaluated this technique to determine whether factor IX can be separated from human T cell leukemia virus-I (HTLV-I) and human immunodeficiency virus (HIV) in pla
Cancer. 1987 Nov 15;60(10):2412-8. Unique Identifier : AIDSLINE MED/88026618
Pizzolo G; Vinante F; Agostini C; Zambello R; Trentin L; Masciarelli M; Chilosi M; Benedetti F; Dazzi F; Todeschini G; et al; Cattedra di Ematologia, Verona University, Italy.
In this study we describe the results of phenotypic, serologic, and functional analyses performed in nine patients with angioimmunoblastic lymphadenopathy (AILD). The study investigates the nature of the T-cell defects which seem to represent a consistent feature in this disease. The study, based on the analysis of T-
Cancer Lett. 1987 Oct;37(1):1-6. Unique Identifier : AIDSLINE MED/88026682
Blakeslee JR Jr; McClure HM; Anderson DC; Bauer RM; Huff LY; Olsen RG; Department of Veterinary Pathobiology, College of Veterinary; Medicine, Ohio State University, Columbus.
Sera from 10 gorillas were tested by indirect immunofluorescent antibody assay, Western blotting and ELISA to Human T-lymphotropic viruses for cross-reacting with antibodies to Simian T-lymphotropic virus I (STLV-I). Four were antibody positive. Of the 4 seropositive gorillas, one has remained healthy, while 3 have di
Sears SD; Fox R; Brookmeyer R; Leavitt R; Polk BF; Department of Medicine, Francis Scott Key Medical Center,; Baltimore, Maryland.
Anergy is almost universal among patients with the acquired immunodeficiency syndrome (AIDS). To determine the prevalence and correlates of anergy in a population at risk for AIDS, we performed skin tests in 1120 gay men who were enrolled in a prospective study of the natural history of human immunodeficiency virus (H
FEBS Lett. 1987 Nov 2;223(2):299-303. Unique Identifier : AIDSLINE MED/88030071
Fujii M; Nakamura M; Ohtani K; Sugamura K; Hinuma Y; Institute for Virus Research, Kyoto University, Japan.
Phorbol esters were employed in studies on the molecular mechanism of the induction of expression of human T-cell leukemia virus type I (HTLV-I) by a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). Experiments using the chloramphenicol acetyltransferase (CAT) system showed that CAT expression directed by t
Barin F; Denis F; Baillou A; Leonard G; Mounier M; M'Boup S; Gershy-Damet G; Sangare A; Kanki P; Essex M; Laboratoire de Virologie, CHRU Bretonneau, Tours, France.
A category of viruses has been identified which is related to human immunodeficiency virus (HIV) but is more closely related to a group of simian retroviruses (STLV-III). These viruses named HTLV-IV, LAV-II, or SBL-6669, are prevalent in West-Africa. In this study, we analysed the cross-reactivity at the protein level
Lundblad JL; Londeree N; Mitra G; Research & Development, Quality Assurance, Cutter Laboratories,; Miles Pharmaceutical, Berkeley, California 94701.
Five commercially available immunoglobulin preparations are characterised with regard to molecular weight distribution, immunoglobulin subclass distribution and antibody content. Preparations processed utilising enzymic or chemical modification demonstrate considerable variance of molecular weight species and subclass
Hansen LL; Wiecha I; Witschel H; Augenklinik im Klinik um Steglitz der Freien Universitat Berlin.
The authors report on two patients who presented with sudden loss of vision, due to irodocyclitis and retinochoroiditis in one patient and optic neuritis in the other. AIDS was diagnosed in both patients on the basis of a positive HIV antibody assay, lymphopenia, and a reduced helper-to-suppressor subset ratio. Soon a
Between 1984 and 1987 (over two-and-a-half years) 30 hospitalized patients with HIV infections of different degrees of severity were ophthalmologically examined. Ocular involvement was found in 17 patients (approx. 57%). In 16 of these 17 patients with pathologic ophthalmologic findings (approx. 94%), AIDS was already
Rosenblatt JD; Gasson JC; Glaspy J; Bhuta S; Aboud M; Chen IS; Golde DW; Department of Medicine, UCLA School of Medicine 90024-1736.
Human T cell leukemia virus (HTLV-II) is an infrequently encountered human T cell leukemia virus first isolated from a patient with atypical hairy cell leukemia. Recently, we identified a second patient infected with HTLV-II who had a similar clinical syndrome of atypical hairy cell leukemia associated with peripheral
Katayama I; Maruyama K; Fukushima T; Nishibe Y; Kayano H; Department of Pathology, Saitama Medical School, Japan.
Sera from 11 Japanese patients with hairy cell leukemia and 4B122, an anti-hairy cell serum produced by the authors, were surveyed by Western blot analyses for cross-reacting antibodies to human T cell leukemia virus (HTLV)-I and -II virions released, respectively, from Lma-66 and Mo-T cell lines. Sera from the majori
Friend murine leukaemia virus complex (FV) causes an immunosuppressive retrovirus-induced disease. In certain mouse strains, FV shows striking similarities to human immunodeficiency virus (HIV) infection in man in that infected mice have severe T-cell immunosuppression but also develop virus-neutralizing antibodies in
Nature. 1987 Nov 12-18;330(6144):184-6. Unique Identifier : AIDSLINE MED/88039118
Hahn BH; Kong LI; Lee SW; Kumar P; Taylor ME; Arya SK; Shaw GM; Department of Internal Medicine, University of Alabama,; Birmingham 35294.
Human immunodeficiency virus type 1 (HIV-1) is the aetiologic agent of AIDS (acquired immune deficiency syndrome) in most countries and probably originated in Central Africa like the AIDS epidemic itself. Evidence for a second major group of human immunodeficiency-associated retroviruses came from a report that West A
Proc Natl Acad Sci U S A. 1987 Nov;84(21):7408-12. Unique Identifier : AIDSLINE MED/88041116
Mosca JD; Bednarik DP; Raj NB; Rosen CA; Sodroski JG; Haseltine WA; Hayward GS; Pitha PM; Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Herpes simplex virus 1 (HSV-1) infection induces transcription of the chloramphenicol acetyltransferase (CAT) gene directed by the long terminal repeat (LTR) of human immunodeficiency virus (HIV) in both transiently and permanently transfected cells containing the HIV-LTR/CAT hybrid gene. To define the mechanism by wh
Schweiz Med Wochenschr. 1987 Aug 29;117(35):1283-8. Unique Identifier : AIDSLINE MED/88042648
Joller-Jemelka H; Grob PJ; Departement fur Innere Medizin, Universitatsspital, Zurich.
Sera were available of 23 individuals before anti-HIV screening tests of the first generation became positive (seroconversion). HIV antigen (p24) became detectable before seroconversion in 21 individuals. HIV antigen disappeared before the first appearance of anti-HIV in 3 instances and shortly after seroconversion in
Berezin VE; Vorkunova GK; Matsevich GR; Zaides VM; Marennikova SS
The technique of the procedure and the results of the use of immune (western) blotting method for studies on viral antigens and detection of antibodies to individual proteins of viral particles are described. The possibility of detection and study of individual viral antigens in the whole plasma of patients or carrier
Balthazar EJ; Megibow AJ; Hulnick D; Cho KC; Beranbaum E; Department of Radiology, New York University Medical; Center/Bellevue Hospital, NY 10016.
Cytomegalovirus is one of the more common opportunistic organisms implicated in the development of esophagitis in patients with AIDS. A review of the radiographic features of 16 proved cases of cytomegalovirus esophagitis showed a spectrum of abnormalities related to the severity o
Am J Med. 1987 Oct;83(4):787-9. Unique Identifier : AIDSLINE MED/88046851
Koop HO; Holodniy M; List AF; Department of Internal Medicine, Good Samaritan Medical Center,; Phoenix, Arizona.
Cutaneous Kaposi s sarcoma occurs rarely in patients receiving long-term corticosteroid therapy. The case of a rapidly progressive form of Kaposi s sarcoma occurring in a 29-year-old Palestinian woman with steroid-dependent Crohn s disease and familial Mediterranean fever is reported. Despite an extensive transfusion
Am J Pathol. 1987 Nov;129(2):345-52. Unique Identifier : AIDSLINE MED/88047091
Baskin GB; Department of Pathology, Delta Regional Primate Research Center,; Tulane University, Covington, LA 70433.
Rhesus monkeys experimentally infected with the lentivirus SIV/Delta become immunodeficient and often die of opportunistic infections. The most frequent of these is cytomegalovirus ( CMV ). The lesions due to reactivated CMV in
Ann Med Interne (Paris). 1987;138(5):331-3. Unique Identifier : AIDSLINE MED/88047733
Harzic M; Mazeron MC; Bertrand C; Laboratoire de Bacteriologie-Virologie, Hopital Saint-Louis,; Paris.
Cytomegalovirus ( CMV ) infection is a major cause of morbidity in immunodepressed patients: the diagnosis is based on the demonstration of CMV viraemia and/or specific IgM and/or a significant rise in antibody titres. This study was undertaken to compare the diag
Ann Med Interne (Paris). 1987;138(5):366-8. Unique Identifier : AIDSLINE MED/88047742
Charpentier B; Lang P; Hiesse C; Fixy P; Lantz O; Bellamy J; Benoit G; Fries D; Laboratoire de Transplantation d'Organes, Hopital de Bicetre,; Kremlin-Bicetre.
An increased incidence of Kaposi s sarcoma is well known in renal transplant recipients in whom it may represent up to 3 p. 100 of all de novo tumours. This sarcoma has a close relationship with the potential oncogenicity of the cytomegalovirus (
Frank KB; McKernan PA; Smith RA; Smee DF; Nucleic Acid Research Institute, Costa Mesa, California 92626.
Inhibition of visna virus replication in vitro by several compounds previously reported to inhibit replication of human immunodeficiency virus (HIV) was examined. Ribavirin concentrations as high as 1 mM reduced virus production by less than 50% relative to controls. The concentration of phosphonoformate reducing viru
Purtilo DT; Department of Pathology, University of Nebraska Medical Center,; Omaha 68105-1065.
Patients with inherited or acquired immunodeficiency disorders are vulnerable to a broad spectrum of opportunistic infectious diseases, but a narrow spectrum of malignancies. These malignancies--B-cell lymphomas, Kaposi s sarcomas, and squamous cell carcinomas--are likely due to failure of immune surveillance to recog
In the last decade it appeared more than once that blood donations were contaminated by hitherto unknown viruses. Due to this fact, further steps have to be included into the manufacturing procedure of even up to now safe products from human plasma to eliminate potential new risks. A procedure is described which enabl
Maeda M; Arima N; Daitoku Y; Kashihara M; Okamoto H; Uchiyama T; Shirono K; Matsuoka M; Hattori T; Takatsuki K; et al; Chest Disease Research Institute, Kyoto University, Japan.
Interleukin 2 ( IL-2 ) receptor/Tac antigen is abnormally expressed on cells of patients with adult T cell leukemia (ATL) caused by infection with human T lymphotropic virus type I (HTLV-I). Twenty-five patients with ATL were examined to determine whether their leukemic
To correlate cytogenetic findings with histology and immunophenotype, 260 newly diagnosed patients with non-Hodgkin s lymphoma (NHL) and 31 with adult T cell leukemia/lymphoma (ATL) were studied at the Fifth International Workshop on Chromosomes in Leukemia-Lymphoma. Clonal chromos
Immunol Lett. 1987 Jul;15(3):221-8. Unique Identifier : AIDSLINE MED/88031426
Tagaya Y; Taniguchi Y; Naramura M; Okada M; Suzuki N; Kanamori H; Nikaido T; Honjo T; Yodoi J; Institute for Immunology, Kyoto University, Faculty of Medicine,; Japan.
In HTLV-I transformed T-cell lines established from the patients with adult T-cell leukemia (ATL), there is a constitutive activation of the normal IL-2 receptor (IL-2-R) gene. These cell lines continuously produce an ATL-derived factor (ADF), an IL-2-R inducing factor
Immunol Lett. 1987 Jul;15(3):249-53. Unique Identifier : AIDSLINE MED/88031430
Noma T; Mizuta T; Rosen A; Hirano T; Kishimoto T; Honjo T; Department of Medical Chemistry, Kyoto University, Faculty of; Medicine, Japan.
Three new human lymphokines, interleukin-5, BSF-2 and BSF-MP6, were shown to be active in the enhancement of the IL-2 receptor expression on T cells, although they do not stimulate growth of the T cells.
Int J Cancer. 1987 Oct 15;40(4):461-8. Unique Identifier : AIDSLINE MED/88031797
Miyamoto K; Tomita N; Ishii A; Miyamoto N; Nonaka H; Kondo T; Sugihara T; Yawata Y; Tada S; Tsubota T; et al; School of Health Sciences, Okayama University, Japan.
Chromosome analysis was performed on 1 patient with diffuse lymphoma of mixed type by histologic diagnosis and on 7 patients with the acute type of adult T-cell leukemia (ATL). Specific abnormalities in chromosome 14 at break band q11 with the assigned locus of the alpha-chain gene of the T-cell antigen receptor were
Miyamoto K; Nishikawa H; Miyata T; Otsuki S; Tomita N; Suzuki C; Ishii A; Hiraki Y; Sugihara T; Kitajima K; et al; School of Health Sciences, Okayama University.
Sera and cerebrospinal fluid (CSF) from patients with human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy (HAM) were analyzed by Western blotting, and normal human leukocytes were transformed by co-cultivation with HAM patients leukocytes. The sera and CSF from all HAM patients formed specific bands wit
Honda M; Yamamoto N; Nagao S; Tokunaga T; Department of Cellular Immunology, National Institute of Health,; Tokyo.
Soluble interleukin 2 receptors (IL 2R) from human retrovirus-infected cells were analyzed. All the T cell lines integrated with human T cell lymphotropic virus (HTLV)-I and -II, or transfected with HTLV-I gag-pX gene, were found to release high levels of IL 2R constitutively. In contrast, this was not found in T cell
Weiss RA; Institute of Cancer Research, Chester Beatty Laboratories,; London.
Over the past 25 years animal retroviruses have been favoured subjects of research by virologists, oncologists, and molecular biologists. Retroviruses have given us reverse transcriptase, oncogenes, and cloning vectors that may one day be exploited for human gene therapy. They have also given us leukaemia and the acqu
Thirty patients, 13 female and 17 male, have been followed from 3 months to 22 years (mean, 81 months; median, 63 months) and special studies have been performed on a proportion of these in order to try to predict malignant evolution. Age at onset was from 20 to 70 years (mean, 43 years; median, 42 years). Duration of
Lancet. 1987 Oct 31;2(8566):996-9. Unique Identifier : AIDSLINE MED/88037755
Grundy JE; Shanley JD; Griffiths PD; Department of Virology, Royal Free Hospital School of Medicine,; London.
The conventional explanation for the high fatality rate due to cytomegalovirus ( CMV ) pneumonitis among allogeneic transplant recipients is that immunosuppression renders the host unable to control replication of this opportun
Lancet. 1987 Nov 7;2(8567):1047-50. Unique Identifier : AIDSLINE MED/88037757
Dalgleish AG; Thomson BJ; Chanh TC; Malkovsky M; Kennedy RC; Clinical Research Centre, Northwick Park Hospital, Harrow.
Polyclonal anti-idiotypic antibodies were raised in mice against anti-Leu3a, a mouse monoclonal anti-human T4 (CD4) antibody that blocks the in-vitro binding of human immunodeficiency virus (HIV) to the CD4 molecule. The anti-idiotypes recognized anti-Leu3a but not OKT4, an anti-human T4 antibody that does not inhibit
Retroviruses are small, RNA-containing enveloped viruses which are widely distributed in nature. They exist in many animal species as well as in man. Exogenous virus strains are horizontally transmitted between individuals of a given species, like all other virus groups. Endogenous virus strains have managed some time
Postgrad Med J. 1987 Jan;63(735):55-6. Unique Identifier : AIDSLINE MED/88040781
Ackerman Z; Levy M; Department of Internal Medicine A, Hadassah University Hospital,; Jerusalem, Israel.
We describe a patient with AIDS in whom recurrent drug eruption and fever following administration of various unrelated agents developed. Previous drug exposure was uneventful. A possible mechanism for this phenomenon is described.
Peruccio D; Crepaldi T; Lovisone E; Paolino F; Foa R; Castagnoli C; Gabrielli A; Cappa PM; Richiardi P; Dipartimento di Genetica, Biologia e Chimica Medica, University; of Torino, Italy.
The expression of HLA class I- like molecules was analyzed on human acute and chronic leukemic cells. The presence on leukemic cells of class I- like molecules, absent on the patient s normal lymphocytes, was examined by complement- dependent lymphocytotoxicity using platelet absorbed alloantisera that recognize HLA-l
Sulkava R; Korpela J; Erkinjuntti T; Department of Neurology, University of Helsinki, Finland.
Patients with human immunodeficiency virus (HIV) have often progressive dementia . Human T cell lymphotropic virus Type I (HTLV-I) infection has not been reported to cause dementia. We tested antibodies to HTLV-I and HIV in serum and cerebrospinal fluid in 69 Finnish patients referr
Am J Med. 1987 Nov;83(5):953-8. Unique Identifier : AIDSLINE MED/88046911
Ratner L; Griffith RC; Marselle L; Hoh M; Wong-Staal F; Saxinger C; Department of Medicine, Washington University, St. Louis,; Missouri 63110.
A 35-year-old black man is described who had a human T-lymphotropic virus type I (HTLV-I) infection while living in a non-endemic region. A lymphoproliferative disorder developed that might be considered as a transition stage between acute and chronic adult T-cell leukemia/lymphoma. This suggests that HTLV-I-induced n
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