Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.
IMMUNOPATHOLOGIC ASPECTS OF KAPOSI'S SARCOMA
Kaposi's Sarcoma: A Text and Atlas. Gottlieb GJ, Ackerman AB, eds. Philadelphia, Lea and Febiger, p. 199-211, 1988.. Unique Identifier : AIDSLINE ICDB/88647202 Modlin RL; Taylor CR; Rea TH; Section of Dermatology, Univ. of Southern California Sch. of; Medicine, Los Angeles, CA
Abstract:
Histogenesis, virology, and immunology of Kaposi's sarcoma (KS) are summarized and the application of immunopathologic methods to KS cases is described. Reactive lymph nodes were obtained from 10 homosexual men with KS (7/10 with neoplasms focally involving the lymph nodes) and control tissues consisting of six reactive tonsils and five reactive lymph nodes from persons who were not homosexual. Blood samples from the same 10 homosexuals and 21 healthy nonhomosexuals were also analyzed. In control specimens, cells positive for the B-lymphocyte marker B-1 were identified predominantly in follicular centers and mantle zones, whereas the mantles surrounding follicular centers in lymph nodes from patients with KS were invaded and partially obliterated with B-1-positive cells appearing in large numbers in the interfollicular T zones. B-1 staining also clearly demonstrated large, irregularly shaped follicular centers. In sections of normal tonsils and reactive lymph nodes from nonhomosexuals, cells of the helper/inducer phenotype (Leu 3-positive) outnumbered the suppressor/cytotoxic phenotype (Leu 2-positive) by 3:1 within the interfollicular T-cell areas. In the follicular centers and mantle zones (B-cell areas), few T cells were present, and helper cells were much more numerous than suppressor cells. In contrast, the reactive lymph nodes from homosexuals with KS contained fewer helper cells and many more phenotypically defined suppressor cells, which gave a reversed ratio of helper:suppressor cells in the mantles and the interfollicular T zones. Comparison of helper:suppressor T-cell ratios in blood and lymph nodes showed that patients with KS had a distinctly abnormal pattern compared with that of controls. KS appears to be derived from endothelial cells, with cytomegalovirus perhaps being involved in its oncogenesis. Study of lymph nodes from patients with KS in acquired immune deficiency syndrome has revealed that major changes of locations and numbers of B and T lymphocytes are associated with this aggressive form of KS. (45 Refs)
Keywords: Acquired Immunodeficiency Syndrome/*PATHOLOGY Antigens, Neoplasm/ANALYSIS B-Lymphocytes/PATHOLOGY Human Immunoenzyme Techniques *Immunohistochemistry Lymph Nodes/PATHOLOGY Sarcoma, Kaposi's/*PATHOLOGY Skin/PATHOLOGY Skin Neoplasms/*PATHOLOGY T-Lymphocytes/PATHOLOGY MONOGRAPH REVIEW REVIEW, TUTORIAL
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Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.
