[S.l. : s.n.], c1987 4 videocassettes (30 min. each) : sd., col. with b&w ; 3/4 in. + 1 guide Unique Identifier : AIDSLINE AV/8801113A
Johnson CF
(Producer) The Legacy is a series of four 30-minute videotapes: Overview: shows the coordination of inservice education by physician, infection control staff and nursing manager to allay fears and answer questions. Moves from the patient s first admission through his last revealing the many pressures experienced by
(Producer) The program provides an example of a counseling session between a physician and a patient whose test were positive for the human immunodeficiency virus (HIV).
Subcommittee on Hospital Operations, Education, and Training Burlington, MA : Massachusetts Hospital Association (5 New England Executive Park, Burlington 01803), c1987 115 p. in various pagings Unique Identifier : AIDSLINE CAT/8811038
Atlanta, Ga. : Centers for Disease Control, Public Health Service, Dept. of Health and Human Services, [1987] 66 p Unique Identifier : AIDSLINE CAT/8811226
Transmitted Diseases. Program Services Branch Atlanta, Ga. : U.S. Dept. of Health and Human Services, Public Health Service, Centers for Disease Control, Center for Prevention Services, Division of Sexually Transmitted Diseases, Program Services Branch, [1987] v, 15 p Unique Identifier : AIDSLINE CAT/8811530
Pacific. Working Group on Viral Haemorrhagic Fever and Viral Neurological Diseases Manila, Philippines : The Office, [1988] 18 p Unique Identifier : AIDSLINE CAT/8810951
Salt Lake City : University of Utah Press, 1989 vii, 241 p (Ethics in a changing world, ISSN 0898-235X ; v. 2) Unique Identifier : AIDSLINE CAT/8811287
Alfred Benzon Symp; 24:1-467 1987. Unique Identifier : AIDSLINE ICDB/88647938
Anonymous; No affiliation given
Proceedings of the Alfred Benzon Symposium 24 on functional aspects of viral carcinogenesis, held June 15-19, 1986 in Copenhagen, Denmark , are presented in eight sections. The first, enhancers and transcriptional factors, discusses
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 56-9, 1987.. Unique Identifier : AIDSLINE ICDB/88647963
Allison AC; Byars NE; Inst. of Biological Sciences, Syntex Res., Palo Alto, CA 94304
Traditional virus vaccines have included attenuated live viruses, which elicit both humoral and cell-mediated immunity (CMI), and inactivated viruses or their components, which elicit circulating IgG antibodies in sufficient concentration to protect humans from disease. The cloning and expression of the genes for the
Med Virol; 6:1-412 1987. Unique Identifier : AIDSLINE ICDB/88648580
Anonymous; No affiliation given
This volume contains the proceedings of the 1986 International Symposium on Medical Virology, held November 12-14, 1986, in Anaheim, California. The symposium was an attempt to bring together individuals working in different areas of medical virology to exchange information that will help in effective control of viral
Kaposi's Sarcoma: A Text and Atlas. Gottlieb GJ, Ackerman AB, eds. Philadelphia, Lea and Febiger, p. 199-211, 1988.. Unique Identifier : AIDSLINE ICDB/88647202
Modlin RL; Taylor CR; Rea TH; Section of Dermatology, Univ. of Southern California Sch. of; Medicine, Los Angeles, CA
Histogenesis, virology, and immunology of Kaposi s sarcoma (KS) are summarized and the application of immunopathologic methods to KS cases is described. Reactive lymph nodes were obtained from 10 homosexual men with KS (7/10 with neoplasms focally involving the lymph nodes) and control tissues consisting of six reacti
IMA J Math Appl Med Biol. 1984;1(3):267-76. Unique Identifier : AIDSLINE MED/88315925
Aron JL; Schwartz IB; Biostatistics Branch, National Cancer Institute, Bethesda,; Maryland 20205.
Problems requiring further development of epidemic theory are discussed. One important area is the association between progressive disease and horizontally-transmitted agents, as in, e.g., the current epidemic of acquired immunodeficiency syndrome (AIDS) which has been linked to spread of a virus. Models of disease tr
Raise E; Gritti FM; Bonazzi L; Monti M; Grillo A; Savoia M; Gambetti M; Pulsatelli L; Casertano MG; Di Figlia C; et al; Divisione Malattie Infettive ed Immunopatologia, Patologia; Clinica Ospedale Maggiore C.A. Pizzardi Bologna.
N Z Med J. 1987 Apr 8;100(821):209-11. Unique Identifier : AIDSLINE MED/88335059
Robinson GM; Thornton NJ; Rout J; Mackenzie N; Wellington Alcohol and Drug Centre.
Surveys of intravenous drug users were undertaken in July 1985 and one year later to assess behaviours which could result in risk of HIV infection and transmission. Ready availability of sterile syringes was reported by 48% in 1986 and 63% in 1985. Sharing of syringes amongst intravenous drug users is a common practic
Ablashi DV; Sturzenegger S; Hunter EA; Palestine AG; Fujikawa LS; Kim MK; Nussenblatt RB; Markham PD; Salahuddin SZ; Laboratory of Cellular and Molecular Biology, National Cancer; Institute, Bethesda, Maryland 20892.
Tears, conjunctival epithelium, and corneoscleral tissue from AIDS patients were used for the isolation of HTLV-III and also for identifying cell types which support its replication. HTLV-III was isolated from tears of AIDS patients (66.6%) by cultivation of cells and fluid from patients eyes with fresh human mononuc
Gritti FM; Raise E; Gualandi G; Bonazzi L; Martuzzi M; Schiattone ML; Di Pede B; Gallo R; Rivano MT; Taruscio D; et al; Infect. Dis. and Immunopathol. Dep., University, Bologna, Italy.
The clinical features of our cases demonstrated some of the already known characteristics of the variable spectrum of HIV infection. DA are the most important risk category in Italy . 10% of the ARC cases evolved into AIDS during a 12-month follow-up, on average. The most frequent OI
Schooley RT; Blumberg RS; Vogt M; Hartshorn K; Hirsch MS; Infectious Disease Unit, Massachusetts General Hospital and; Harvard Medical School, Boston 02114.
Persistent generalized lymphadenopathy during HIV infection is now a well classified syndrome featuring multiple chronic lymph node enlargement frequently associated with further symptoms (diarrhea, nocturnal sweating, loss of weight, fever): it is invariably accompanied by serious alterations of the cell-mediated imm
McCue JP; Sasagawa PK; Hein RH; Department of Chemistry & Physics, Salem State College,; Massachusetts 01970.
IgG was isolated from plasma at low temperatures using the Cohn fractionation method, and then processed to three different products in order to evaluate how chemical and physical manipulations affect antibodies. Evaluation of the antibodies was done by measuring their ability to bind human immunodeficiency virus,
The purpose of this paper is to discuss a hypothesis corroborating the use of hydrolytic enzymes in AIDS/ARC/LAS patients, showing high levels of circulating immune complexes (CIC). Other diseases, revealing high CIC-levels as well, may be improved or even cured by eliminating CIC. The results obtained from experience
King MB; Institute of Psychiatry, Denmark Hill, London.
An unselected series of outpatients infected with the human immunodeficiency virus (HIV) who attended two London hospitals were interviewed to assess their relationship with their general practitioner. Although most of the 192 patients were registered with a general practitioner, the doctors of only one half knew of t
The emergence of the acquired immune deficiency syndrome has provoked a widespread review of policies for infection control. Incomplete knowledge about the human immunodeficiency virus (HIV), hepatitis B virus, and mycobacteria has until now been compensated for by adopting overkill precautions for patients who were t
Can Med Assoc J. 1988 Sep 1;139(5):383-8. Unique Identifier : AIDSLINE MED/88310636
Losos J; Wells G; Elmslie K; Verveniotis G; Clayton AJ; Laboratory Centre for Disease Control, Department of National; Health and Welfare, Tunney's Pasture, Ottawa, Ont.
In the first 5 years of surveillance of reports of the acquired immune deficiency syndrome (AIDS) in Canada , from February 1982, the Laboratory Centre for Disease Control, Ottawa, was notified of 1133 cases reported through provincial ministries of health that met the case definiti
Can Med Assoc J. 1988 Sep 15;139(6):557-9, 561-2. Unique Identifier : AIDSLINE MED/88310673
Ford P; Robertson D; Department of Medicine, Queen's University, Ont.
Although AIDS is often thought of as a big-city disease, it is also becoming a serious health care issue for doctors and other health care workers in small-city Canada . Kingston, Ont., is one of those small cities, and of the facilities trying to come to grips with a disease about
Can J Psychiatry. 1988 Jun;33(5):409-11. Unique Identifier : AIDSLINE MED/88310707
McMillan J; Noone J; Tombaugh T; University of British Columbia, Vancouver.
Acquired Immune Deficiency Syndrome (AIDS) has made a wide impact not limited to those persons who have or are likely to contact it. A case history of a man with a near-delusional belief he had AIDS is presented to exemplify the individual issues that concern about AIDS may raise. Thorough exploration of the dynamic i
Ben-Haim SA; Ben-Ami H; Edoute Y; Goldstien N; Barzilai D; Department of Internal Medicine C, Rambam Medical Center, Faculty; of Medicine, Technion-Israel Institute of Technology, Haifa.
A case of an HIV-positive young drug addict presenting with fever, respiratory distress, and pulmonary infiltrates is reported. Pulmonary talcosis was diagnosed by transbronchial biopsy. The differential diagnosis of pulmonary infiltrates in HIV-positive patients is reviewed and the predisposition of drug addicts to d
Antony MA; Brandt LJ; Klein RS; Bernstein LH; Department of Medicine, Montefiore Medical Center, Albert; Einstein College of Medicine, Bronx, New York 10467.
A multitude of opportunistic infections has been documented in virtually every organ system of patients with the acquired immunodeficiency syndrome (AIDS). Prominent among these are infections of the gastrointestinal tract. However, studies of large numbers of patients documenting the frequency of such involvement are
D-Penicillamine, an amino acid analogue of cysteine, has been shown to inhibit the transactivation of HIV-1 LTR by the transactivator protein, tat protein. The transactivation was studied in Jurkat cells co-transfected with plasmids containing HIV-LTR sequences fused to the bacterial chloramphenicol acetyltransferase
1. All patients undergoing gastrointestinal endoscopy must be considered at risk for HIV and appropriate cleaning/disinfection measures taken for endoscopes and accessories. 2. Thorough manual cleaning with detergent, of the instrument and its channels is the most important part of the cleaning/disinfection procedur
Provencher D; Valme B; Averette HE; Ganjei P; Donato D; Penalver M; Sevin BU; Division of Gynecologic Oncology and Cytopathology, University of; Miami School of Medicine, Florida 33101.
Rosendaal FR; Smit C; Varekamp I; Brocker-Vriends A; Suurmeijer TP; Briet E; Department of Haematology, University Hospital Leiden, The; Netherlands.
More than 75% of all Dutch haemophiliacs participated in a mail survey that included a section on acquired immunodeficiency syndrome (AIDS). Although no cases of haemophilia-related AIDS had been reported in the Netherlands at the time of our survey, the threat of AIDS had cau
Philpot CR; Harcourt C; Edwards J; Grealis A; Sydney STD Centre, Sydney Hospital, New South Wales, Australia.
One hundred and thirty two female prostitutes and 55 non-prostitutes who were tested for antibodies to human immunodeficiency virus (HIV) were surveyed by questionnaire at this centre. The two groups were well matched for age and were very similar in other except for numbers of their sexual partners. Questions were as
Moore TC; Spruck CH; Said SI; Department of Surgery, UCLA School of Medicine, Torrance 90509.
Vasoactive intestinal peptide (VIP) is a 28 amino acid-residue neurovascular and gut peptide with a number of important biological activities. Recent in vitro studies suggest an immunomodulatory (depressant) role for VIP. In the present in vivo studies, employing the Hall and Morris sheep lymphocyte traffic model, acu
J Med Virol. 1988 May;25(1):1-10. Unique Identifier : AIDSLINE MED/88316234
Ulrich PP; Busch MP; el-Beik T; Shiota J; Vennari J; Shriver K; Vyas GN; Department of Laboratory Medicine, University of California, San; Francisco 94143-0100.
We have evaluated a number of methodological variables effecting the expression of human immunodeficiency virus (HIV) in cultured peripheral blood mononuclear cells (PBMCs) of 93 healthy anti-HIV-positive and 72 healthy seronegative subjects. For optimal HIV recovery, PBMCs had to be freshly separated from whole blood
Grant I; Atkinson JH; Hesselink JR; Kennedy CJ; Richman DD; Spector SA; McCutchan JA; Department of Psychiatry, School of Medicine, University of; California, San Diego, La Jolla 92093.
AIDS, ARC, and other HIV-associated diseases were originally conceptualised exclusively in terms of defects in cell-mediated immunity and its consequences. But it is now becoming clear that HIV disease can also be a primary neuropsychiatric disorder, although the precise mechanism by which the retrovirus causes impair
Med Hypotheses. 1988 Jun;26(2):143-4. Unique Identifier : AIDSLINE MED/88318376
Melles Z; Municipal Hospital, Kazincbarcika, Hungary.
The problem of Acquired Immunodeficiency Syndrome is not yet solved. Based on information published so far a correlation is supposed between Chlamydia trachomatis infection and Acquired Immunodeficiency Syndrome. The author supports his hypothesis by citing epidemiological, pathophysiological and pathological similari
Med Hypotheses. 1988 Jun;26(2):145-7. Unique Identifier : AIDSLINE MED/88318377
Becker Y; Department of Molecular Virology, Faculty of Medicine, Hebrew; University, Jerusalem, Isreal.
Computerized Chou-Fasman analysis of the secondary structure of human T-cell leukemia viruses (HTLV-I, HTLV-II) and human immunodeficiency virus (HIV) envelope proteins revealed that only one antigenic epitope (amino acids EAL) is shared by the three viruses. A similar antigenic epitope is also found in human and rat
Malim MH; Hauber J; Fenrick R; Cullen BR; Howard Hughes Medical Institute, Duke University Medical Center,; Durham, North Carolina 27710.
The pathogenic human retrovirus human immunodeficiency virus type 1 (HIV-1) encodes two trans-acting nuclear proteins, tat and rev, whose functional expression is essential for viral replication in vitro. The tat protein greatly enhances the expression of both structural and regulatory genes of HIV-1 (linked to the vi
Proc Natl Acad Sci U S A. 1988 Sep;85(18):6944-8. Unique Identifier : AIDSLINE MED/88320552
Prince AM; Horowitz B; Baker L; Shulman RW; Ralph H; Valinsky J; Cundell A; Brotman B; Boehle W; Rey F; et al; Lindsley F. Kimball Research Institute, New York Blood Center, NY; 10021.
To assess the possible efficacy of passive immunization against human immunodeficiency virus (HIV) an immune globulin was prepared from plasma of HIV-seropositive donors selected to be among those having the top 12.5% of virus-neutralizing antibody titers. The immune globulin was treated with pepsin to render it intra
Uldry PA; Regli F; Service de neurologie, Centre hospitalier universitaire vaudois,; Lausanne.
Unilateral facial palsies were observed in three patients with positive serology for HIV. Two patients presented a second unilateral peripheral seventh nerve palsy after extraction of a tooth. Recovery was complete in each case. Peripheral neuropathies are present in 20% of cases with AIDS but cranial neuropathies are
Kemp BE; Rylatt DB; Bundesen PG; Doherty RR; McPhee DA; Stapleton D; Cottis LE; Wilson K; John MA; Khan JM; et al; Department of Medicine, University of Melbourne, Repatriation; General Hospital, Victoria, Australia.
An antibody detection procedure based on agglutination of autologous red cells has been developed for samples of whole blood. A nonagglutinating monoclonal antibody to human red blood cells conjugated to a synthetic peptide antigen (in this case residues 579 to 601 of the HIV-1 envelope precursor, Arg-Ile-Leu-Ala-Val-
Cernescu C; Cajal N; Institut de Virologie, Stefan S. Nicolau, Bucarest, Roumanie.
The high number of AIDS cases diagnosed in different European countries imposed to reconsider the opinion that European epidemic is just reflecting the American epidemic. The whole morbidity des not point out the peculiar elements of HIV infection propagation in Europe. The exponential rise of reported case number dur
Grauer K; Kravitz L; University of Florida, College of Medicine, Gainesville 32601.
Health care providers are becoming increasingly reluctant to perform mouth-to-mouth resuscitation. While it may be prudent to exercise caution in this endeavor, it is important to appreciate the potential consequences of delaying this lifesaving procedure.
Levy WS; Varghese PJ; Anderson DW; Leiboff RH; Orenstein JM; Virmani R; Bloom S; Department of Medicine, George Washington University, Washington,; DC 20037.
Ogden DM; Fischer HE; Liu FJ; Rios A; Lichtiger B; Division of Laboratory Medicine, University of Texas M.D.; Anderson Hospital and Tumor Institure, Houston 77030.
The authors studied the circulating fibronectin concentrations in the plasma of 24 patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) and of 74 age- and sex-matched healthy blood donors. They adapted a commercially available turbidimetric immunoassay for use with a centrifugal analyz
Gc allele frequencies were determined in Haitian immigrants, a group at high risk for AIDS. Gc2, an allele associated with disease resistance, is infrequent in this group; Gc1f is frequent.
PURPOSE: In order to evaluate the relationship between cachectin/tumor necrosis factor (TNF) and cachexia in the acquired immunodeficiency syndrome (AIDS), we studied the serum levels of endogenous cachectin/TNF in subjects with human immunodeficiency virus (HIV) infection. PATIENTS AND METHODS: Fifty-three serum samp
Am J Psychiatry. 1988 Sep;145(9):1130-2. Unique Identifier : AIDSLINE MED/88324722
Mahorney SL; Cavenar JO Jr; Psychiatry Service, VA Medical Center, Durham, NC 27705.
Delusions presented by patients with psychiatric disorders are often a combination of psychopathology and current events. The authors present three cases that document the delusion of having acquired immune deficiency syndrome (AIDS) in patients who were not members of high-risk groups but had psychiatric disorders. T
Koehler JE; LeBoit PE; Egbert BM; Berger TG; University of California, San Francisco.
Cutaneous lesions develop frequently in patients infected with human immunodeficiency virus (HIV). We describe the clinical features of four patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex who developed angiomatous nodules involving skin and bone, 2 of whom were scratched by a cat.
Lake-Bakaar G; Tom W; Lake-Bakaar D; Gupta N; Beidas S; Elsakr M; Straus E; State University of New York Health Science Center, Brooklyn.
STUDY OBJECTIVE: To correlate oral ketoconazole absorption with gastric acid secretion in patients with the acquired immunodeficiency syndrome (AIDS). DESIGN: Prospective measurement of maximal acid output and oral ketoconazole absorption with and without 0.1-N hydrochloric acid. SETTING: Hospital in-patients in unive
A widespread maculo-papular cutaneous rash appeared on a HIV-positive young bisexual Cambodian man. He was treated for Mycobacterium tuberculosis and Pneumocystis carinii infections. He had been residing in France for seven years. Histology showed, within the dermis, abundant extra
Topley JM; Department of Paediatrics and Child Health, Medical School,; University of Zimbabwe.
A total of 188 children with positive serology for HIV were identified during an 18 month period. Two seronegative children with clinical features of AIDS had seropositive mothers. Ten children were asymptomatic on initial testing; one has since died with infection. The commonest presenting features were generalised l
Ann Rheum Dis. 1988 Aug;47(8):695-6. Unique Identifier : AIDSLINE MED/88325679
Goh BT; Jawad AS; Chapman D; Winceslaus SJ; Forster GE; Perry JD; Whitechapel Clinic, London Hospital.
A patient suffering from the acquired immune deficiency syndrome (AIDS), who developed swelling of the left elbow four weeks after Staphylococcus aureus septicaemia is reported. The cause was osteomyelitis of the olecranon process.
Arch Gen Psychiatry. 1988 Sep;45(9):859-64. Unique Identifier : AIDSLINE MED/88325822
Atkinson JH Jr; Grant I; Kennedy CJ; Richman DD; Spector SA; McCutchan JA; Department of Psychiatry, UCSD School of Medicine, La Jolla; 92093.
We used structured diagnostic interviews and rating scales to assess lifetime prevalence of psychiatric disorders, by DSM-III criteria, among an unselected sample of 56 ambulatory homosexual men in four groups: men with acquired immunodeficiency syndrome (AIDS), men with AIDS-related complex (ARC), men asymptomatic or
Jamin D; Shulman I; Lam HT; Aguilar S; Shields M; Cohen J; Gill P; Levine A; University of Southern California School of Pharmacy, Los; Angeles, 90033.
Drugs and chemicals containing multiple reactive carbonyl groups have been postulated to produce nonimmunologic positive direct antiglobulin tests (DATs) both in vitro and in vivo. Suramin sodium, a reverse transcriptase inhibitor that was under investigation as a potential treatment for human immunodeficiency virus i
Thung SN; Gerber MA; Benkov KJ; Guttenberg M; Gordon RE; Lillian and Henry M. Stratton-Hans Popper Department of; Pathology, Mount Sinai School of Medicine, City University of New; York, NY 10029.
The pathologic changes in the liver of a child with human immunodeficiency virus infection are described. The liver biopsy specimens show chronic active hepatitis with bile duct damage. To our knowledge, the etiology and pathogenesis of chronic liver disease in children with acquired immunodeficiency syndrome is not k
Currie J; Benson E; Ramsden B; Perdices M; Cooper D; Mental Health Research Institute of Victoria, Melbourne,; Australia.
Using infrared oculography, we recorded the eye movements in a group of patients with acquired immunodeficiency syndrome (AIDS), with or without the AIDS dementia complex (ADC). Our aim was to determine whether the severity of dementia could be correlated with abnormalities of eye
Masengo-Bwanga; Bula Bula A; Tambwe Mbuyi M; Maloba Nday; Kalenga B; Luboya N; Service de medecine interne, Cliniques universitaires de; Lubumbashi, Zaire.
26 AIDS cases (13 males and 13 females) have been noticed in the internal medicine service of the Lubumbashi University Clinics, town at the boundary of the south-east of Zaire . The clinical data are conventional: only heterosexual transmission seems prevalent. The shortage of HIV
Bouree P; Espinoza P; Coco Cianci O; Loue P; Departement des Maladies Tropicales, C. H. U. Bicetre, Kremlin; Bicetre.
A prospective survey among 116 subjects native of Black Africa and residing in prison was carried on, in order to estimate the prevalence of parasitosis, HB Virus and HI Virus infections. These subjects, all males, were selected at random among Black Africans, which were representative of 6.5% of the prisoners in the
Davis AE; ENT Department, Queen Elizabeth Medical Centre, Edgbaston,; Birmingham.
Homograft materials are extensively used in various surgical procedures in otolaryngology, but with the increasing prevalence of human immunodeficiency virus (HIV) in the population this practice must be reviewed. Careful donor selection and antibody testing reduce but do not fully eliminate the risk of an HIV positiv
Sahai J; Department of Pharmacy and Pharmaceutics, Medical College of; Virginia, Virginia Commonwealth University, Richmond 23298-0581.
A case of cryptococcal meningitis in a patient with the acquired immunodeficiency syndrome (AIDS) is described, as well as the epidemiology, pathogenesis, clinical manifestations, diagnosis, and therapeutic management of the disease. In July 1987 a 38-year-old white man was admitted to the hospital because of confusio
Rapini RP; Department of Dermatology, University of Texas Medical School,; Houston.
Physicians today are seeing many more immunosuppressed patients because of the prevalence of infection with the human immunodeficiency virus, use of chemotherapy for malignancies, and immunosuppressive therapy for patients undergoing organ transplantation. This paper gives many practical tips for the evaluation of ski
Blimkie CJ; Roache P; Hay JT; Bar-Or O; School of Physical Education and Athletics, McMaster University,; Hamilton, Ontario, Canada.
The purpose of this study was to describe anaerobic peak and mean power characteristics of arms as a function of age, gender and body composition among 50 girls and 50 boys 14 to 19 years of age. Peak (PP) and mean power (MP) output were determined during arm cranking (Wingate anaerobic test). Fat-free weight (FFW) wa
The serum free fatty acid (FFA), cortisol and urinary creatinine, 17-hydzoxycorticosteroid and 17-oxosteroid concentrations of acquired immunedeficiency syndrome (AIDS-I: beginning and AIDS-II: end phase) and AIDS-related complex (ARC) patients were determined. Both groups were compared to a control group (healthy men
Rogers C; Klatt EC; Department of Pathology, Los Angeles County-University of; Southern California Medical Center 90033.
The acquired immunodeficiency syndrome (AIDS) is most often a sexually transmitted disease acquired via male genital tract secretions. We performed a retrospective controlled study of testicular tissue taken from 100 AIDS patients at autopsy to determine the nature and spectrum of macroscopic and microscopic changes a
Dictor M; Attewell R; Department of Pathology, University Hospital, Lund, Sweden.
We studied retrospectively 529 cases of Kaposi s sarcoma (KS) reported to the Swedish Cancer Registry between 1958 and 1982 to determine incidence rates, survival and rate ratios, together with the frequency and types of associated malignancies. The age-standardized (Swedish population 1970) incidence rate generally i
Pinter A; Honnen WJ; Laboratory of Retroviral Biology, Public Health Research; Institute of the City of New York, NY 10016.
A sensitive and efficient radioimmunoprecipitation procedure is described which provides an alternative to Western blotting assays for characterizing antibodies directed against human immunodeficiency viruses (HIV-1). Reaction of solubilized preparations of HTLV-III with 125I-labeled Bolton-Hunter reagent leads to the
Katner HP; Buckley RL; Smith MU; Henderson AM; Department of Internal Medicine, Mercer University School of; Medicine, Macon, Georgia 31201.
With estimates as high as 1.8 million individuals infected with human immunodeficiency virus (HIV) in the United States , the majority asymptomatic, it is crucial that all physicians routinely use adequate disinfection procedures for medical instruments. The protosigmoidoscopic disinfec
Batki SL; Substance Abuse Services, San Francisco General Hospital,; California 94110.
Methadone maintenance programs are treating increasing numbers of HIV-infected IVDUs. Methadone treatment offers the opportunity to constructively intervene in the lives of these patients by helping to prevent the further spread of AIDS and by providing medical, psychiatric, and social services. The need for expanded
Faltz BG; Bureau of Drug Abuse Services, San Jose, California 95116.
Some of the barriers to effective dual treatment of substance abuse and AIDS-related diagnoses have been detailed in this article, and some practical strategies to improve the response of treatment providers in caring for this difficult population of patients have been offered. While there are many problems associated
Pohl MI; Pride Institute, Eden Prairie, Minnesota 55344.
As AIDS becomes more and more a part of everyone s life, it is imperative for CDTPs to provide a basic course of information about AIDS for all patients; and in order to adequately counsel and to provide this information, CDTP staff need to explore their own attitudes and responses to the disease. In addition, CDTPs m
JAMA. 1988 Oct 7;260(13):1901-5. Unique Identifier : AIDSLINE MED/88333274
Hegarty JD; Abrams EJ; Hutchinson VE; Nicholas SW; Suarez MS; Heagarty MC; Department of Pediatrics, Harlem Hospital Center, New York, NY; 10037.
To estimate the cost of hospital care for children infected with the human immunodeficiency virus (n = 37) at Harlem Hospital Center, New York, a cost-based inventory of medical resource consumption was developed. Six thousand thirty-five inpatient days were audited by retrospective chart review. The total cost of car
JAMA. 1988 Oct 7;260(13):1906-9. Unique Identifier : AIDSLINE MED/88333275
Kemper K; Forsyth B; Department of Pediatrics, Yale University School of Medicine, New; Haven, Conn.
Stimulated by reports that some children who are seropositive for human immunodeficiency virus (HIV+) have been abandoned in the hospital, we studied the extent of, and reasons for, medically unnecessary hospital use at Yale-New Haven (Conn) Hospital among HIV+ children. We reviewed inpatient stays for all HIV+ childr
JAMA. 1988 Oct 14;260(14):2085-7. Unique Identifier : AIDSLINE MED/88333303
Garry RF; Witte MH; Gottlieb AA; Elvin-Lewis M; Gottlieb MS; Witte CL; Alexander SS; Cole WR; Drake WL Jr; Department of Microbiology and Immunology, Tulane University; School of Medicine, New Orleans, LA 70112.
The acquired immunodeficiency syndrome was first recognized as a clinical entity in the United States in the early 1980s; however, the issue of when human immunodeficiency virus, the causative agent of the acquired immunodeficiency syndrome, was introduced into at-risk populations in t
N Engl J Med. 1988 Oct 13;319(15):961-4. Unique Identifier : AIDSLINE MED/88334659
Burke DS; Brundage JF; Redfield RR; Damato JJ; Schable CA; Putman P; Visintine R; Kim HI; Division of Communicable Diseases and Immunology, Walter Reed; Army Institute of Research, Washington, D.C. 20307-5100.
In a program screening civilian applicants for U.S. military service for human immunodeficiency virus (HIV) infection, we studied the frequency of false positive diagnoses retrospectively among applicants seropositive for HIV in a subpopulation with a very low prevalence of infection. That subpopulation was defined as
Filice G; Cereda PM; Varnier OE; Institute of Infectious Diseases, IRCCS San Matteo, Pavia, Italy.
An important requirement for the development of a vaccine against the human immunodeficiency virus (HIV-1), the causative agent of AIDS, is a readily available animal model that would allow possible immunogens to be evaluated. The only species to have been infected with HIV-1 so far is the chimpanzee. However, the sca
Delattre P; Service de pediatrie, Centre hospitalier de Cayenne, Guyane; francaise.
From 1980 to 1987, 15 children infected by HIV were born in Guyana from seropositive Haitian mothers. All these children presented the classical picture of HIV infection associated with a chronic extensive prurigo (7/15). There were 8 AIDS and 7 ARC cases. Five infants (4 AIDS, 1 A
Pathol Res Pract. 1988 Jun;183(3):253-5. Unique Identifier : AIDSLINE MED/88335825
Falk S; Helm EB; Hubner K; Stutte HJ; Department of Pathology, J. W. Goethe-University, Frankfurt/M.
The case of an AIDS patient with visceral leishmaniasis diagnosed by bone marrow and liver biopsy is reported. Despite the infrequent association between HIV infection and leishmaniasis pathologists and clinicians alike should be alerted to the possibility of leishmaniasis occurring as yet another opportunistic infect
Bessinger CD Jr; Department of Surgery, Greenville Memorial Hospital, South; Carolina.
Preventing the transmission of human immunodeficiency virus during surgical procedures requires attention to barrier techniques and to measures designed to prevent injury. Measures to prevent injury must focus on minimizing both the number of people at risk and the opportunities for injury to occur. Special rules are
Bishopric GA; d'Agay MF; Schlemmer B; Sarfati E; Brocheriou C; Departement d'Anatomie Pathologique, Saint-Louis, Paris, France.
A case of inflammatory pseudotumour of the lung in a patient with the acquired immunodeficiency syndrome due to infection by Corynebacterium equi is described.
Dock NL; Lamberson HV Jr; O'Brien TA; Tribe DE; Alexander SS; Poiesz BJ; American Red Cross Blood Services-Syracuse Region, NY.
Blood donors reactive by enzyme-linked immunosorbent assay for antibody to the human immunodeficiency virus (HIV) who showed atypical patterns of viral core protein reactivity on Western blot were monitored for several months. Characterization of their antibodies was performed by 1) use of recombinant HIV proteins; 2)
Kleinman S; Secord K; American Red Cross Blood Services, Los Angeles-Orange Counties; Region, CA.
We have estimated the risk of transmitting HIV infection from a unit of HIV seronegative blood collected in Los Angeles and Orange Counties, CA from March 1985 through February 1987. Our method consisted of lookback investigations and anti-HIV testing of living recipients of HIV seronegative units donated by persons w
Grumet FC; MacPherson JL; Hoppe PA; Smallwood LA; Department of Pathology, Stanford University Medical Center, Palo; Alto, CA 94304.
In light of increasing public and employee concern over potential infectious hazards associated with blood and other body fluids, several government agencies (the Food and Drug Administration, the Centers for Disease Control, the Occupational Safety and Health Administration, the Environmental Protection Agency, the H
A substantial rise in the number of AIDS cases has been observed during the past year in many African countries, and HIV-2 indigenous transmission and increased disease have since gained importance in Senegal . Both for HIV-1 and HIV-2 diagnosis, ELISA positivity is followed by a W
Tyrrell DA; Common Cold Unit, Harvard Hospital, Salisbury, UK.
There is a great deal of experience on the development and testing of antiviral vaccines but, in the case of HIV, it will be necessary to analyse carefully our understanding of the biology of the organism, the natural history and pathology of the disease (in particular immunity or resistance to infection or clinical s
Am J Cardiol. 1988 Oct 1;62(10 Pt 1):789-93. Unique Identifier : AIDSLINE MED/88338505
Reilly JM; Cunnion RE; Anderson DW; O'Leary TJ; Simmons JT; Lane HC; Fauci AS; Roberts WC; Virmani R; Parrillo JE; Pathologic Anatomy Department, Clinical Center, National; Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
To evaluate possible relations between clinical and histopathologic cardiac findings in patients with the acquired immune deficiency syndrome (AIDS), 58 consecutively autopsied AIDS patients were reviewed retrospectively. Twenty-six (45%) had histopathologic myocarditis. Fifteen of these 26 (58%) had greater than or e
Am J Epidemiol. 1988 Oct;128(4):711-8. Unique Identifier : AIDSLINE MED/88338591
Kristal AR; Nasca PC; Burnett WS; Mikl J; Fred Hutchinson Cancer Research Center, Seattle, WA 98104.
The extent to which the epidemic of human immunodeficiency virus (HIV) infection has changed the descriptive epidemiology of cancers other than Kaposi s sarcoma is unknown. This study, based on cancer surveillance data (New York State Cancer Registry) and mortality statistics (New York City death certificates), examin
Am J Epidemiol. 1988 Oct;128(4):719-28. Unique Identifier : AIDSLINE MED/88338592
Coates RA; Calzavara LM; Soskolne CL; Read SE; Fanning MM; Shepherd FA; Klein MH; Johnson JK; Department of Preventive Medicine and Biostatistics, Faculty of; Medicine, University of Toronto, Ontario, Canada.
As part of a prospective study in Toronto, Canada of male sexual contacts of men with either acquired immunodeficiency syndrome (AIDS) or an AIDS-related condition (primary cases), separate interviews were conducted in 1984-1985 with primary cases and their corresponding sexual con
Am J Epidemiol. 1988 Oct;128(4):729-39. Unique Identifier : AIDSLINE MED/88338593
Coates RA; Calzavara LM; Read SE; Fanning MM; Shepherd FA; Klein MH; Johnson JK; Soskolne CL; Department of Preventive Medicine and Biostatistics, Faculty of; Medicine, University of Toronto, Ontario, Canada.
A total of 246 healthy male sexual contacts of men with either acquired immunodeficiency syndrome (AIDS) or an AIDS-related condition were recruited into a prospective study in Toronto, Canada between July 1984 and July 1985. At induction, data were collected on the sexual relation
Gloeb DJ; O'Sullivan MJ; Efantis J; Department of Obstetrics and Gynecology, University of Miami; School of Medicine/Jackson Memorial Medical Center, Florida.
The clinical courses and initial neonatal outcomes of 50 patients with human immunodeficiency virus infection were followed on antepartum, intrapartum, and/or postpartum bases, between July 18, 1986, and December 27, 1987, at the University of Miami School of Medicine/Jackson Memorial Medical Center. The mean age at t
Aust Paediatr J. 1988 Jun;24(3):199-202. Unique Identifier : AIDSLINE MED/88339746
Goldwater PN; Kernick CG; Martin AJ; Delbridge RG; Matthews NT; Department of Microbiology, Adelaide Children's Hospital,; Australia.
A case of congenital or perinatal Acquired Immunodeficiency Syndrome (AIDS), the first recognized case of mother to child human immunodeficiency virus (HIV) infection resulting in the full-blown syndrome in Australia , is reported. The baby who died in November 1985 was diagnosed
Searle ES; Eastbourne Health Authority, East Sussex, UK.
Even if we could prevent more infections with the human immunodeficiency virus (HIV) today, we know from the numbers of well seropositive people in the world that a sharp rise in the number of AIDS patients and deaths is inevitable in the coming years. This article describes how one London Health Region (population 3.
Giesecke J; Scalia-Tomba G; Berglund O; Berntorp E; Schulman S; Stigendal L; Department of Environmental Health and Infectious Disease; Control, Stockholm County Council, Karolinska Hospital, Sweden.
The times from infection with the human immuno-deficiency virus (HIV) to the onset of the first clinical symptom and the development of AIDS were studied prospectively in 98 haemophiliacs and 48 blood transfusion recipients infected with the virus. Patients were followed up for a median of 61 months after infection, t
The initial symptoms of an HIV-1 infection were observed in four patients. The following were characteristic for the acute primary phase: (a) initial maculopapular exanthema, especially of the trunk, with occasional transition into a papulovesical appearance; (b) involvement of the oral mucosa, often of aphthous chara
Robertson GA; Kostek BM; Schleif WA; Lewis JA; Emini EA; Department of Virus and Cell Biology, Merck, Sharp and Dohme; Research Laboratories, West Point, Pennsylvania 19486.
A microtiter cell-culture assay is described for measuring neutralizing antibody activity directed against the human immunodeficiency virus (HIV). The assay relies upon inhibition of HIV-mediated cell killing of infected MT-4 lymphoid cells. The assay exhibits comparable sensitivity to two other methods used for such
Jackson JB; Coombs RW; Sannerud K; Rhame FS; Balfour HH Jr; Department of Laboratory Medicine and Pathology, University of; Minnesota Medical School, Minneapolis 55455.
Peripheral blood mononuclear cells from 142 consecutive patients with antibodies to human immunodeficiency virus type 1 (HIV-1) were cultured for HIV-1. All 72 patients with symptoms of HIV-1 infection were culture positive, as were 69 of 70 asymptomatic patients. Of the 142 patients, 132 (93%) were culture positive w
The continued recognition process of dental public health as a specialty of dentistry served as an opportunity for the specialty to rediscover and reevaluate itself. What it found was a discipline that has evolved for 38 years to address the issues of a dynamic society. Dr. Abraham Kobren, ADA past-president has state
Elovaara I; Seppala I; Poutiainen E; Suni J; Valle SL; Department of Neurology, University of Helsinki, Finland.
We analyzed the intrathecal humoral immunologic response in 42 human immunodeficiency virus (HIV)-infected patients. Eighteen patients had clinical neurologic abnormalities, while the remaining 24 patients were neurologically symptom-free. Nine of the neurologically symptomatic patients at early infection had slight n
Proc Natl Acad Sci U S A. 1988 Sep;85(18):6836-40. Unique Identifier : AIDSLINE GENBANK/M20786
Hirosawa S; Nakamura Y; Miura O; Sumi Y; Aoki N; First Department of Medicine, Tokyo Medical and Dental; University, Japan.
We have isolated overlapping phage genomic clones covering an area of 26 kilobases that encodes the human alpha 2-plasmin inhibitor. The alpha 2-plasmin inhibitor gene contains 10 exons and 9 introns distributed over approximately 16 kilobases of DNA. To our knowledge, the number of introns is the highest yet reported
Of a total of 5.6 million blood donations by 1.6 million German Red Cross donors between July, 1985 and December, 1987 tested for HIV antibodies 210 were found to be positive in at least one Western blot. Calculated per quarter, the prevalence (for first-time donors) of 10 per 100,000 in 1985 decreased to 4 per 100,00
Goudsmit J; Lange JM; Smit L; Bakker M; Klaver B; Danner SA; Coutinho RA; Virology Department, University of Amsterdam, Academic Medical; Center, Netherlands.
Different stages of HIV infection are marked by expression of HIV genes, production of HIV antibodies, formation of antigen/antibody complexes and clearance of such complexes. Transient HIV antigenemia appearing generally 6-8 weeks prior to HIV antibody (HIV-Ab) seroconversion and lasting 3-4 months is generally seen
Fipps DR; Damato JJ; Brandt B; Burke DS; Department of Virus Disease, Walter Reed Army Institute of; Research, Walter Reed Army Medical Center, Washington, DC; 20307-5100.
The effects of multiple freeze-thaw cycles and various temperatures (-20 degrees C, 4 degrees C, 25 degrees C, 37 degrees C) on the reactivity of human immunodeficiency virus (HIV) antibodies were evaluated using current ELISA, recombinant, and Western blot methodologies. Twenty consecutive freeze-thaw cycles and stor
Ferns RB; Tedder RS; Donoghue JL; Department of Medical Microbiology, Middlesex Hospital,; University College Medical School, London, U.K.
An anti-HIV 1 competitive ELISA was developed using a monoclonal anti-HIV 1 gag to capture viral antigen to the solid phase. This format of assay was compared with a competitive ELISA where a polyclonal human anti-HIV 1 was used, to capture the viral antigen. Several benefits were observed using the monoclonal-antibod
N Engl J Med. 1988 Oct 6;319(14):889-96. Unique Identifier : AIDSLINE MED/88334625
Pizzo PA; Eddy J; Falloon J; Balis FM; Murphy RF; Moss H; Wolters P; Brouwers P; Jarosinski P; Rubin M; et al; Pediatric Branch, National Cancer Institute, Bethesda, MD 20892.
To produce concentrations of zidovudine ( AZT ) in plasma and cerebrospinal fluid that would provide constant inhibition of the replication of human immunodeficiency virus (HIV), we gave AZT by continuous intravenous infusion to 21 children ranging in a
Goudsmit J; Thiriart C; Smit L; Bruck C; Gibbs CJ; Virology Department, Academic Medical Center, Amsterdam, The; Netherlands.
Sera from chimpanzees inoculated respectively with HTLV-III B, LAV, HTLV-III RF and brain tissue from an AIDS patient were analysed for neutralizing activity by two methods: a cell fusion inhibition test (CFI) using HTLV-III B infected cells as inoculum and CD4+ cells as target and a replication inhibition test (RIT)
Spornraft P; Froschl M; Ring J; Meurer M; Goebel FD; Ziegler-Heitbrock HW; Riethmuller G; Braun-Falco O; Dermatologische Klinik und Poliklinik, Ludwig Maximilians; Universitat Munchen, F.R.G.
Thirty-seven men (36 homosexual or bisexual and one heterosexual) with epidemic Kaposi s sarcoma and underlying HIV infection were followed up over a period of up to 32 months. Fourteen patients (38%) died, with a median survival time of 7.2 months after the diagnosis of AIDS. Seventeen patients (46%) presented with o
Dainiak N; Worthington M; Riordan MA; Kreczko S; Goldman L; Department of Medicine, St Elizabeth's Hospital, Boston,; Massachusetts 02135.
Peripheral blood cytopenias are a serious, dose-limiting toxicity of AZT therapy in patients infected by HIV. To evaluate the mechanism by which cytopenias develop, AZT effects of haematopoietic differentiation and growth were measured in serum-free,
Gout O; Rouquette B; Tournier-Lasserve E; Barre-Sinoussi F; Lyon-Caen O; Chermann JC; Clinique de Neurologie et de Neuropsychologie, Hopital de la; Salpetriere, Paris, France.
We observed the development of an acute encephalopathy in a healthy human immunodeficiency virus (HIV) seropositive man. HIV was isolated from cerebrospinal fluid but not from peripheral blood. Signs and symptoms resolved quickly without treatment. This viral isolate could be propagated only in blood cord lymphocytes,
Maddon PJ; McDougal JS; Clapham PR; Dalgleish AG; Jamal S; Weiss RA; Axel R; Department of Biochemistry and Molecular Biophysics, College of; Physicians and Surgeons, Columbia University, New York, New York; 10032.
The T cell surface molecule CD4 interacts with class II MHC molecules on the surface of target cells as well as with the envelope glycoprotein of human immunodeficiency virus (HIV). Internalization of CD4 molecules is observed after exposure of CD4+ T cells to either phorbol esters or appropriate antigen-bearing targe
Shen JY; Barnes PF; Rea TH; Meyer PR; Department of Medicine, University of Southern California, School; of Medicine, Los Angeles 90033.
Monoclonal antibodies and immunoperoxidase staining were used to characterize the cellular subpopulations in lymph nodes from 10 patients with tuberculous lymphadenitis, seven of whom had symptomatic human immunodeficiency virus (HIV) infection. CD4+ cells were significantly fewer in nodes of patients with HIV infecti
Fernandez-Cruz E; Fernandez AM; Gutierrez C; Garcia-Montes M; de la Morena MT; Rodriguez-Villanueva J; Longo N; Zabay JM; Department of Immunology, Hospital General Gregorio Maranon,; Madrid, Spain.
We have studied immunological, serological and clinical abnormalities in 264 HIV-positive and HIV-negative drug abusers. Ninety percent of the 264 drug addicts (mean age 26 +/- 0.8 years) were found to have HIV antibodies and there was a significant increase (P less than 0.01) in the frequency of HIV antibody positivi
Bleiweiss IJ; Jagirdar JS; Klein MJ; Siegel JL; Krellenstein DJ; Gribetz AR; Strauchen JA; Department of Pathology, Mt Sinai Medical Center, New York, New; York 10029.
Pneumocystis carinii pneumonia is a frequent manifestation of the acquired immune deficiency syndrome (AIDS). It usually presents radiologically as diffuse bilateral infiltrates and histologically as a foamy, eosinophilic intra-alveolar exudate containing the organisms cysts. We recently studied two rare cases of P c
Skotnicki AB; Zatz M; Sztein MB; Goldstein AL; Schulof RS; Dept. Hematology, University School of Medicine, Cracow, Poland.
The PHA-induced synthesis of interleukin 2 ( IL-2 ) by peripheral blood lymphocytes (PBL) from 9 normal and 8 pre-AIDS individuals was evaluated. IL-2 content in supernatant fluids of PBL cultures derived from pre-AIDS patients was only around 20% of that found in normal
Pifer LW; Wolf BL; Weems JJ Jr; Woods DR; Edwards CC; Joyner RE; Departments of Pediatrics, University of Tennessee, Memphis; 38163.
The present study was conducted to determine the prevalence and significance of Pneumocystis carinii antigenemia in patients with acquired immunodeficiency syndrome (AIDS) and clinically or invasively diagnosed P. carinii pneumonitis. Single serum specimens from 20 AIDS patients invasively examined for P. carinii orga
de Wolf F; Lange JM; Houweling JT; Coutinho RA; Schellekens PT; van der Noordaa J; Goudsmit J; Department of Virology, University of Amsterdam, the Netherlands.
The relation between serological and immunologic profiles and the risk of developing AIDS was assessed in 306 initially asymptomatic, human immunodeficiency virus-infected homosexual men studied for 30 mo. Twenty-nine men developed AIDS (attack rate, 16.8%). The attack rate in core antibody-negative men was 35.7%; thi
Chaffee S; Leeds JM; Matthews TJ; Weinhold KJ; Skinner M; Bolognesi DP; Hershfield MS; Department of Pediatrics, Duke University Medical Center, Durham,; North Carolina 27710.
Derivatives of the CEM T and WIL-2 B cell lines showed striking diversity in their responses to the HTLV-IIIB strain of the human immunodeficiency virus (HIV). Several stable phenotypic patterns could be defined, based on whether cells were permissive (P+, P-) for virus production, were sensitive or insensitive to cyt
Proc Natl Acad Sci U S A. 1988 Aug;85(16):5941-5. Unique Identifier : AIDSLINE GENBANK/J03654
Zagury JF; Franchini G; Reitz M; Collalti E; Starcich B; Hall L; Fargnoli K; Jagodzinski L; Guo HG; Laure F; et al; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, MD 20892.
The isolation from macaques of retroviruses related to human immunodeficiency virus (HIV) led to the identification of a second group of human retroviruses (termed HIV-2), which are prevalent in West Africa and closely related to the simian immunodeficiency virus (SIV). We have cloned and determined the complete nucle
Proc Natl Acad Sci U S A. 1988 Aug;85(16):6102-6. Unique Identifier : AIDSLINE MED/88320389
Richardson NE; Brown NR; Hussey RE; Vaid A; Matthews TJ; Bolognesi DP; Reinherz EL; Laboratory of Immunobiology, Dana-Farber Cancer Institute,; Boston, MA.
The external segment of the T4 (CD4) glycoprotein functions as the T-cell surface receptor for human immunodeficiency virus by binding the major viral coat protein (gp120) with relatively high affinity. To more precisely define the region of T4 involved in gp120 interaction, we used purified, soluble forms of T4 ancho
Proc Natl Acad Sci U S A. 1988 Aug;85(16):6127-31. Unique Identifier : AIDSLINE MED/88320394
Hayashi S; Phadtare S; Zemlicka J; Matsukura M; Mitsuya H; Broder S; Clinical Oncology Program, National Cancer Institute, Bethesda,; MD 20892.
Although several antiretroviral compounds are already known, almost no acyclic nucleoside derivatives lacking an oxacyclopentane have been reported to exert significant inhibition against human immunodeficiency virus type 1 (HIV-1) in vitro. We found two unsaturated acyclic nucleoside derivatives, adenallene [9-(4 -hy
Strebel K; Klimkait T; Martin MA; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, MD 20892.
A 16-kilodalton protein expressed in cells producing the human immunodeficiency virus (HIV-1) was identified as the gene product of the vpu open reading frame. When expressed in vitro, the 81-amino acid vpu protein reacted with about one-third of the serum samples from AIDS patients that were tested, indicating that t
Weiss LM; Perlman DC; Sherman J; Tanowitz H; Wittner M; Albert Einstein College of Medicine, Bronx, NY 10461.
Isosporiasis is an uncommon but important diarrheal disease of humans that, like cryptosporidiosis, is life-threatening in patients with the acquired immunodeficiency syndrome (AIDS). Isospora belli infection responds rapidly to therapy with trimethoprim-sulfamethoxazole, but patients with AIDS have a high rate of adv
Deluol AM; Cenac J; Michon C; Matheron S; Coulaud JP; Savel J; Service de Parasitologie, Hopital Claude-Bernard, Paris.
The study of 11 cases of isosporiasis (Isospora belli) shows that this opportunistic coccidia, alone or with Cryptosporidium, causes severe prolonged diarrhoea which worsens the prognosis and evolution of AIDS patients. A low prevalence (0.7%) is found in subjects from tro
A survey of prevalence of anti-HIV in patients with haemophilia A, B or von Willebrand s disease in the UK was carried out in July-August 1986 and 86 of the 109 centres contacted sent in information. Of 2330 haemophilia A patients, 955 (41%) were found to be anti-HIV positive; 26 (6%) out of 401 haemophilia B patients
Ujhelyi E; Krall G; Fust G; Medgyesi GA; Hollan SR; Zimonyi I; Berkessy S; Nagy K; Foldes I; Mayer V; National Institute of Haematology and Blood Transfusion,; Budapest, Hungary.
Incidence of HIV antibodies have been studied in 617 patients with congenital bleeding disorders. Screening was performed with the Organon ELISA test, repeatedly positive samples were tested with four different confirmatory assays. HIV antibodies were found in 3/356 patients with haemophilia A, 21/114 patients with ha
Scorza Smeraldi R; Fabio G; Lazzarin A; Eisera N; Uberti Foppa C; Moroni M; Zanussi C; Institute of Internal Medicine, Infectious Diseases and; Immunopathology, University of Milan, Italy.
Thirty-one AIDS patients were typed for HLA A, B, C, and DR antigens. We confirmed that frequency of B35 is significantly higher in patients than in controls. No significant frequency differences in other HLA antigens were found. The analysis of HLA distribution in AIDS patients by risk categories suggests that B35 is
Pauza CD; Price TM; Developmental Biology Laboratory, Salk Institute for Biological; Studies, San Diego, California 92138.
The rates of internalization and uncoating of 32P-labelled human immunodeficiency virus (HIV) in the human T lymphoid cell line CEM are consonant with a receptor-mediated endocytosis mechanism of entry. This interpretation was affirmed by electron microscopic observation of virions within endosomes. Virus binding and
Med Microbiol Immunol (Berl). 1988;177(4):181-7. Unique Identifier : AIDSLINE MED/88334351
Matsuyama T; Hamamoto Y; Kobayashi S; Kurimoto M; Minowada J; Kobayashi N; Yamamoto N; Department of Virology and Parasitology, Yamaguchi University; School of Medicine, Japan.
The effect of natural lymphotoxin (n-LT) on CD4+ MOLT-4 cells and those cells producing human immunodeficiency virus (HIV), MOLT-4/HIVHTLV-IIIB cells, was studied. Four days after treatment with n-LT, a significant cytotoxic/cytostatic effect was observed predominantly on MOLT-4/HIVHTLV-IIIB cells. Furthermore, with r
Ahmad N; Venkatesan S; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, MD 20892.
In studies of the genetics of human immunodeficiency virus type 1 (HIV-1), the product of the nef gene, formerly known as F, 3 -orf, or B-ORF, was a negative regulator of HIV-1 replication. Proviruses with mutations in the nef gene replicated better than their standard counterparts during transient expression, and the
Pulmonary function was measured in 169 male patients seropositive for the human immunodeficiency virus (HIV). The transfer factor for carbon monoxide (TLCO) in symptom free patients and patients with persistent generalised lymphadenopathy was normal (greater than 83% of predicted values). Patients with the AIDS relate
Lynch MA; Cho KC; Jeffrey RB Jr; Alterman DD; Federle MP; Department of Radiology, University of California, San Francisco.
The CT and clinical findings are presented in seven patients with diffuse peritoneal malignancy caused by non-Hodgkin lymphoma. All seven patients had CT evidence of ascites, omental infiltration, and peritoneal implants mimicking carcinomatosis. Bulky retroperitoneal or mesenteric adenopathy was present in only one p
Olsen WL; Jeffrey RB Jr; Sooy CD; Lynch MA; Dillon WP; Department of Radiology, University of California, San Francisco; 94143.
The CT and/or MR findings were reviewed in 43 patients with head and neck disease; 27 had AIDS, 14 had AIDS-related complex, and two had positive human immunodeficiency virus serologies. Fourteen patients had infections, 15 had tumors, and 15 had benign lymphoid hyperplasia. Deep cervical infections were caused by bac
Carson DA; Wasson DB; Department of Basic and Clinical Research, Scripps Clinic and; Research Foundation, La Jolla, California 92037.
Recently, several pyrimidine and purine 2 ,3 -dideoxynucleosides have been shown to inhibit the replication of the human immunodeficiency virus-1 (HIV), the causative agent of the acquired immune deficiency syndrome (AIDS). These compounds are usually prepared by reduction of the corresponding 2 -deoxynucleosides. The
Denning DW; Division of Infectious Diseases, Stanford University School of; Medicine, San Jose, CA 95128.
This paper describes the few case reports of neurological effects of acute (primary) HIV infection. Following a typical primary illness (fever, sore throat, headache, rash, lymphadenopathy, superficial oral ulcers, conjunctivitis, leukopenia and thrombocytopenia) aseptic meningitis, myelopathy, spinal myoclonus, perip
Mathe G; Institut du Cancer et d'Immunogenetique, Hopital Paul-Brousse,; Villejuif, France.
We have compiled epidemiologic data on AIDS which failed to support systematic screening for HIV viruses and which allow a certain optimism regarding the future of the epidemic: there seems to be, in New York, a decrease in the frequency of affected homosexuals, probably because they have followed advice on hygiene. H
BMJ. 1988 Aug 6;297(6645):381-4. Unique Identifier : AIDSLINE MED/88310265
Elvin KM; Bjorkman A; Linder E; Heurlin N; Hjerpe A; Department of Parasitology, National Bacteriological Laboratory,; Stockholm, Sweden.
Diagnosis of pneumocystis pneumonia is based on identifying Pneumocystis carinii cytochemically in material from the lung. The silver methenamine staining methods most commonly used are technically difficult and lack specificity. The diagnostic value of immunocytological identification of the parasite was evaluated by
Rankin JA; Pulmonary Section, Yale University School of Medicine, New Haven,; Connecticut.
The lower respiratory tract of normal healthy individuals is kept sterile and disease-free by formidable local and systemic immune system defenses. In patients with AIDS, these defenses are severely compromised. Undoubtedly, alterations in both local and systemic forces make the host vulnerable to infection by opportu
Levine SJ; White DA; Division of Pulmonary Medicine, Cornell University Medical; College, New York, New York.
This article covers the biology, epidemiology, and pathology of infection with Pneumocystis carinii. The clinical presentation, course, and treatment of pneumonia caused by this organism in patients infected with the human immunodeficiency virus is discussed.
Pitchenik AE; Fertel D; Bloch AB; University of Miami Medical Center, Florida.
TB is common in the setting of HIV-induced immunosuppression, especially among demographic groups with a high background prevalence of tuberculous infection. It is often the first (sentinel) infectious disease to appear, extrapulmonary and disseminated disease is common, the chest x-ray picture is frequently atypical,
Fels AO; Cornell University Medical College, New York, New York.
Bacterial pneumonias occur with increased frequency and can be associated with increased morbidity in the HIV-infected population compared with normals. The pathogens that most frequently cause community-acquired pneumonias are S. pneumoniae, H. influenzae, and occasionally S. aureus. These pneumonias usually respond
Ognibene FP; Shelhamer JH; Critical Care Medicine Department, National Institutes of Health,; Bethesda, Maryland.
Pulmonary KS may occur in up to 20 to 25 per cent of patients with cutaneous KS. The presenting symptoms of pulmonary KS are indistinguishable from those of opportunistic pathogens that cause pneumonia. It most frequently presents with the symptoms of cough or dyspnea; however, fever, hemoptysis, and stridor have been
Teirstein AS; Rosen MJ; Mount Sinai School of Medicine, New York, New York.
Lymphocytic interstitial pneumonia is a common complication of HIV infection in children, but uncommon in adults. It is characterized clinically by the presence of cough and dyspnea, diffuse pulmonary infiltrates on chest x-ray, restrictive pulmonary dysfunction, and hypoxemia. This constellation of findings usually e
Stover DE; Meduri GU; Cornell University Medical College, New York, New York.
The clinical significance of pulmonary function tests (including blood gas analysis) lies in their sensitivity for detecting PCP. PCP has most consistently been found to cause abnormalities in the DLCO and the exercise arterial blood gas; both are highly sensitive for the presence of Pneumocystis infection. These test
Golden JA; Sollitto RA; University of California, San Francisco, School of Medicine.
A review of the radiologic manifestations of AIDS pulmonary diseases, with an emphasis on the utility of gallium scanning in the context of the normal or equivocal chest x-ray, is presented.
Clement MJ; Luce JM; Hopewell PC; University of California, San Francisco.
A broad spectrum of lung disease occurs in association with HIV infection. Included are both infectious and neoplastic processes and idiopathic disorders. To insure prompt, accurate, and efficient diagnosis, a logical, staged sequence of tests should be applied. Chest films and, in some instances, pulmonary function t
Rubinstein A; Morecki R; Goldman H; Albert Einstein College of Medicine, Bronx, New York.
Pulmonary diseases contribute significantly to the morbidity and mortality in children infected with the human immunodeficiency virus. The wide array of lung diseases spans from early acute bacterial infections, to the lymphoid interstitial pneumonitis/pulmonary lymphoid hyperplasia complex, to opportunistic infection
Garay SM; Plottel CS; New York University School of Medicine, New York.
This review provides an overview of the risk of nosocomial infection in the AIDS era. Airborne spread of Mycobacterium tuberculosis from affected patients has re-emerged as a hazard to hospital personnel. The risk of acquiring clinical illness due to Pneumocystis carinii or cytomegalov
Miller NS; Nance MA; Brummitt CF; Hoj KB; Nichol K; Gold MS; Department of Psychiatry, New York Hospital-Cornell Medical; Center, White Plains 10605.
The authors present a case of confusion and mood disturbance caused by a focal cerebral fungal (phycomycosis) infection in an otherwise healthy intravenous drug addict. A review of the literature found only 9 cases of phycomycosis with localized cerebral involvement. This report describes the sixth occurrence of phyco
Nine ELISA tests and one particle agglutination test for the detection of HIV antibodies were analysed using serial dilutions of Western blot-confirmed positive serum samples. These samples were diluted in HIV antibody negative human serum in a range of 1:10 to 1:10,000 or 1:100,000. Remarkable differences in sensitiv
Costello C; Department of Haematology, St Stephen's Hospital, London.
Peripheral blood and bone marrow changes are commonly seen in disease associated with human immunodeficiency virus (HIV). This annotation aims to summarise these changes and to suggest possible factors entailed in their occurrence.
Proc Natl Acad Sci U S A. 1988 Sep;85(17):6498-502. Unique Identifier : AIDSLINE MED/88320468
Nair MP; Pottathil R; Heimer EP; Schwartz SA; Department of Pediatrics, University of Michigan, Ann Arbor; 48109-2029.
Recombinant and synthetic peptides corresponding to envelope proteins of the human immunodeficiency virus (HIV) were examined for their effects on the activities of lymphocytes from normal donors in vitro. Although lymphocytes cultured with env-gag peptides produced significant amounts of IgG, addition of env-gag pept
Proc Natl Acad Sci U S A. 1988 Sep;85(18):6612-6. Unique Identifier : AIDSLINE MED/88320488
Seelmeier S; Schmidt H; Turk V; von der Helm K; Max von Pettenkofer Institute, University of Munich, Federal; Republic of Germany.
The protease encoded by the human immunodeficiency virus (HIV) processes the viral gag and gag-pol protein precursor by posttranslational cleavage. In this study we have demonstrated by site-specific mutagenesis (Asp----Thr) and by pepstatin A inhibition that the recombinant HIV protease is an aspartic-type protease.
Goldschmidt RH; Dong BJ; Johnson MA; Cello JP; Simon RP; Family Practice Inpatient Service, San Francisco General; Hospital, CA 94110.
The acquired immunodeficiency syndrome (AIDS) has become a problem of enormous clinical importance in the United States . This article describes the major clinical syndromes in adults with AIDS and offers approaches to their evaluation and treatment.
Tobinai K; Minato K; Ohtsu T; Mukai K; Kagami Y; Miwa M; Watanabe S; Shimoyama M; Hematology-Oncology and Clinical Cancer Chemotherapy Division,; National Cancer Center Hospital, Tokyo, Japan.
Immunoblastic lymphadenopathy (IBL)-like T-cell lymphoma is a distinct peripheral T-cell lymphoma, which closely resembles angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) and/or IBL, but is characterized by focal or sheet-like proliferation of immunoblasts and pale cells of T-cell nature. In this report,
Salamone FR; Cunha BA; Division of Pharmacy Services, Memorial Sloan Kettering Cancer; Center, New York, NY 10021.
The chemistry, spectrum of activity, mechanism of action, pharmacokinetics, adverse effects, and dosage and administration of pentamidine are reviewed, and the role of the drug in treating Pneumocystis carinii infections in immunocompromised patients is discussed. Pentamidine isethionate, an aromatic diamidine compoun
Five commercial assays for detecting HIV antigen were evaluated using a panel of 40 coded samples in six laboratories. All assays were capable of detecting HIV-1 antigen (HIV-1 Ag), and are likely to prove useful for monitoring supernatant fluids from a variety of cell cultures. The concentration of HIV-1 protein whic
Huang KH; Watters JK; Case P; Urban Health Study, San Francisco, California 94117.
The instruments used for psychological assessment have been under close scrutiny for many years. In particular, ethnic and racial minorities have pointed out that misapplication of instruments standardized to White middle-class norms can result in incorrect assessments. An analogous situation exists with IVDUs. In the
Chesebro B; Wehrly K; Laboratory of Persistent Viral Diseases, Rocky Mountain; Laboratories, National Institute of Allergy and Infectious; Diseases, Hamilton, Montana 59840.
Accurate and sensitive quantitation of infectious human immunodeficiency virus (HIV) has been difficult to achieve. In this report, a quantitative focal immunoassay (FIA) for HIV was developed using human HeLa cells rendered susceptible to HIV infection by introduction of the CD4 gene via a retrovirus vector. Infected
Med Microbiol Immunol (Berl). 1988;177(4):189-94. Unique Identifier : AIDSLINE MED/88334352
Mayer-Siuta R; Keil LB; DeBari VA; Department of Medicine, St. Joseph's Hospital, Seton Hall; University, Graduate School of Medical Education, Paterson, NJ; 07503.
We wish to report the results of a retrospective study of patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC) as well as a group of asymptomatic human immunodeficiency virus (HIV)-infected individuals, in whom we examined markers of systemic autoimmune disease including anti-cell ant
Pathol Res Pract. 1988 Jun;183(3):223-52. Unique Identifier : AIDSLINE MED/88335824
Gosztonyi G; Cervos-Navarro J; Institute of Neuropathology, Free University Berlin, F.R.G.
Electron microscopy and in particular, immunohistochemical examination techniques have substantially improved the chances to attain an etiologic diagnosis in viral encephalitis. The application of these techniques is needed first of all in the examination of cerebral biopsy specimens, but they can contribute to the cl
Brunet P; Bolgert F; Pierrot-Deseilligny C; Service de Neurologie, Hopital de la Salpetriere, Paris.
Neurological manifestations of HIV infection are recognised at different phases of the evolution of the disease. During the late stages opportunistic neuro-meningeal infections and tumors develop as a result of the immuno-suppression. There exist, however, various manifestations which evolve independently of the immun
Gutman D; Goldenberg CJ; Department of Microbiology and Immunology, University of Miami; School of Medicine, FL 33101.
Human immunodeficiency virus type 1 (HIV-1), in contrast with most other retroviruses, encodes trans-regulatory proteins for virus gene expression. It is shown in this study, by means of an in vitro splicing system, that nuclear extracts obtained from cells infected with HIV-1 contain a factor (or factors) that specif
Koyanagi Y; O'Brien WA; Zhao JQ; Golde DW; Gasson JC; Chen IS; Department of Microbiology and Immunology, UCLA School of; Medicine 90024.
Some strains of human immunodeficiency virus type 1 (HIV-1) can infect primary monocytes and monocyte-derived macrophages in vitro. In this report, the effect of cytokines on the production of one of these strains that shows a tropism for mononuclear phagocytes, designated HIV-1JR-FL, was studied. Primary peripheral b
Grindon AJ; Critchley SE; Ward JW; American Red Cross, Atlanta Region, Georgia.
Recipients of untested blood from donors who at a subsequent donation were positive for HIV antibody by enzyme immunoassay (EIA) were evaluated, whether the result on Western blot (WB) assay was negative (EIA+/WB-) or positive (EIA+/WB+). For 109 EIA+/WB- donors, 78 recipients were tested for HIV antibody, and 3 (4%)
Dalgleish AG; Kennedy RC; Clinical Research Centre, Northwick Park Hospital, Harrow,; Middlesex, UK.
Numerous studies have documented that antibodies may regulate the immune system and form the basis of vaccines, namely anti-idiotype vaccines. Antibodies carry individual idiotype antigenic determinants against which antibodies can be formed. When the anti-idiotype recognizes the same site that recognizes the primary
Am J Public Health. 1988 Oct;78(10):1305-11. Unique Identifier : AIDSLINE MED/88338844
Cook RJ; Dickens BM; Faculty of Law and Faculty of Medicine, University of Toronto,; Canada.
During the period between 1977 and the first quarter of 1988, 35 countries liberalized their abortion laws and four countries limited grounds for the procedure. Most legislation has extended abortion eligibility through traditional indications such as danger to maternal health or fetal handicap, but a number of other
Lunardi-Iskandar Y; Georgoulias V; Vittecoq D; Ammar A; Rozenbaum W; Meyer P; Jasmin C; Unite d'Oncogenese Appliquee (INSERM U 268), Villejuif,; France.
The in vitro proliferation capacity of peripheral blood committed T-cell precursors (T-CFC) from LAS patients was studied in order to define whether this parameter could be associated with transition to AIDS. In all patients a significantly (P less than 0.0001) decreased plating efficiency was detected. However, the l
Mannhalter JW; Wolf HM; Pum M; Banekovich M; Hutterer J; Brandstatter R; Eibl MM; Institute of Immunology, University of Vienna, Austria.
Immunological parameters previously shown to constitute an increased risk for progression towards AIDS have been observed in clinically asymptomatic individuals considered to be at risk for this syndrome. These parameters include severely decreased numbers of T helper cells (count below 400/mm3 blood for CD4+ cells we
Sipka S; Nagy K; Szegedi G; 3rd Department of Internal Medicine, University Medical School of; Debrecen, Hungary.
Adenosine reduced the expression of CD4 antigen both in HIV infected and uninfected H9 T cells. The continuous presence of adenosine (1 mumol/ml) resulted in a remarkable delay of HIV expression in the infected cells. A relationship is suggested in the effects of HIV and adenosine on the human T cells.
Am J Med. 1988 Sep;85(3):428-31. Unique Identifier : AIDSLINE MED/88324518
Roberts DE; Berman SM; Nakasato S; Wyle FA; Wishnow RM; Segal GP; Medical Service, Veterans Administration Medical Center, Long; Beach, California 90822.
Lake-Bakaar G; Quadros E; Beidas S; Elsakr M; Tom W; Wilson DE; Dincsoy HP; Cohen P; Straus EW; State University, New York Health Science Center, Brooklyn.
Wordell CJ; Hauptman SP; Department of Pharmacy, Thomas Jefferson University Hospital,; Philadelphia, PA 19107.
A 44-year-old man with acquired immunodeficiency syndrome (AIDS) and Pneumocystis carinii pneumonia (PCP) who suffered adverse effects from treatment with trimethoprim-sulfamethoxazole (TMP-SMX) and was then treated with pentamidine isethionate is described, and approved and investigational drugs used in the managemen
Janson DD; Teasley KM; Pharmaceutical Services, University of Minnesota Hospital and; Clinic, Minneapolis 55455.
A patient with acquired immunodeficiency syndrome (AIDS) who required aggressive nutritional intervention via home parenteral nutrition therapy is described, and nutritional status, etiology and therapeutic management of AIDS-associated malnutrition, role of nutrition support, and factors for consideration in using pa
EMBO J. 1988 Jul;7(7):2117-30. Unique Identifier : AIDSLINE MED/88329000
Wu FK; Garcia JA; Harrich D; Gaynor RB; Department of Medicine, UCLA School of Medicine.
Transcription of the human immunodeficiency virus type 1 (HIV-1) is regulated by viral proteins and cellular factors that bind to the viral long terminal repeat (LTR). At least five regions of the HIV LTR serve as binding sites for HeLa cellular proteins. One region containing two copies of the sequence GGGACTTTCC fun
Facchetti F; Lucini L; Gavazzoni R; Callea F; First Department of Pathology, Spedali Civili of Brescia, Italy.
In this study we report the histopathological features in a series of 88 biopsies from patients with cutaneous Kaposi s sarcoma; immunohistochemical examination for Factor VIII related antigen has been carried out on frozen and paraffin-embedded sections. The patient groups comprised 50 elderly patients, seven of whom
The fact that the conference drew participants from hospices around the country acknowledged this group s willingness to accept responsibility for caring for AIDS patients.
Lindhardt BO; Ulrich K; Kusk P; Hofmann B; Laboratory of Tumor Virology, Fibiger Institute, Danish Cancer; Society, Copenhagen.
To examine a possible relationship between decreased immune function and serological parameters, such as human immunodeficiency virus (HIV) antigenaemia and the quality and quantity of whole virus antibodies and antibodies against the major core protein p24, we investigated 160 healthy HIV infected individuals (CDC cl
Med Hypotheses. 1988 Jun;26(2):107-11. Unique Identifier : AIDSLINE MED/88318369
Hollins TD
Among the possible affects of the HIV virus on T-cells in Acquired Immune Deficiency Syndrome is the cell membrane distortion of the T4 cell protein receptor for Genetically Related Macrophage Factor (GRF). The integrity of this specific T-cell receptor takes on profound significance due to its relationship to soluble
Mosier DE; Gulizia RJ; Baird SM; Wilson DB; Medical Biology Institute, La Jolla, California 92037.
The pressing need for a better experimental system for AIDS research has brought into sharp focus the shortcomings of available animal models and the practical and ethical limitations of studies of immune responses and viral pathogenesis in humans. Current studies of the human immune responses are limited to relativel
Magnani G; Calzetti C; Campari M; Degli Antoni A; Lehndorf H; Cattedra di Malattie Infettive-Universita degli Studi di Parma.
Between August 1985 and June 1987, 809 subjects at risk for AIDS have been studied. 231 (28.5%) were seropositive for human immunodeficiency virus (HIV) antibodies. The seropositivity rate was 41% among drug addicts, 20.5% among homosexual/bisexual males, 19.7% among sexual partners of seropositive individuals. None o
Marshall DW; Brey RL; Cahill WT; Houk RW; Zajac RA; Boswell RN; Department of Neurology, US Air Force (USAF) Medical Center,; Lackland Air Force Base (AFB), Tex. 78236-5300.
This report summarizes the results of neurologic and cerebrospinal fluid (CSF) study findings in over 400 of the 649 human immunodeficiency virus-infected US Air Force personnel, evaluated as of Dec 31, 1987. Eighty percent of these patients were entirely asymptomatic and immunologically normal, 13% had low T-helper l
Monkhouse WS; Moran P; Freedman A; Department of Human Morphology, University of Nottingham Medical; School.
Medicament contact dermatitis can be troublesome in external ear disease. In this work the effects on the guinea pig external ear of instillation twice daily for 3 weeks of benzalkonium chloride, Cerumol, gentamicin, the pharmaceutical base for Gentisone HC, hydrocortisone and propylene glycol were studied using light
Boutte P; Richelme C; Berard E; Albertini M; Gillet JY; Mariani R; Clinique medicale infantile, Hopital de Cimiez, Nice.
The problems of embryo-foetopathy associated with drug-dependent mothers were determined from published data and from a series of 60 neonates born of heroin-addicted mothers. Low weight at birth resulting from prematurity and/or hypotrophy was frequent. Monitoring of labour and the presence of a specialized medical te
Perronne C; Zahraoui M; Leport C; Salmon D; Pangon B; Bricaire F; Vilde JL; Service des Maladies infectieuses et tropicales, Hopital Claude; Bernard, Paris.
Between May, 1983 and September, 1987, 8 per cent of the patients hospitalised for an HIV infection (i.e. 30 patients, 20 with an ARC and 10 with AIDS) had tuberculosis. The percentage of patients originating from Central Africa or Haiti was important (23 per cent). Tuberculosis was
The paradoxical bronchoconstriction observed with commercially available isotonic ipratropium bromide nebuliser solution (Atrovent) in patients with asthma results from an adverse reaction to the preservatives, benzalkonium chloride and ethylenediaminetetra-acetic acid (EDTA). The airway response to inhaled Atrovent a
Heldin CH; Hammacher A; Nister M; Westermark B; Ludwig Institute for Cancer Research, Uppsala, Sweden.
The finding that PDGF production is common in normal as well as transformed cells indicate that PDGF has a function in autocrine and paracrine stimulation of cells in several physiological and pathological conditions. The expression of mRNA for the two chains of PDGF are independently regulated. The fact that the diff
Mahir WS; Millard RE; Booth JC; Flute PT; Department of Haematology, St George's Hospital Medical School,; London.
Defects of immunoregulation which occur in haemophilia, reflected by numerical changes in T lymphocyte subsets, have been further investigated in functional studies. Polyclonal T-cell activation by the mitogen phytohaemagglutinin (PHA) and specific stimulation by cytomegalovirus (
Krowka J; Stites D; Mills J; Hollander H; McHugh T; Busch M; Wilhelm L; Blackwood L; Department of Laboratory Medicine, University of California, San; Francisco 94143.
Lymphocytes from many HIV-infected asymptomatic individuals or patients with AIDS-related conditions (ARC) and from all AIDS patients were unable to proliferate in vitro in response to UV-inactivated cytomegalovirus ( CMV ). Th
Streicher H; Schlar L; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, Maryland.
The discovery of the group of human retroviruses and their associated diseases has had a profound impact on the way we think of viral-associated human diseases and their social, medical, economic, and even ethical aftereffects. This article discusses the biology, pathophysiology, and clinical consequences of human ret
Gold JW; Cornell University Medical College, New York, New York.
HIV is a retrovirus. Infection with HIV results in a progressive loss of immune function, primarily of the T-helper lymphocyte, although other arms of the immune system are secondarily affected. Patients who develop AIDS are amazingly susceptible to the development of opportunistic infections and neoplastic diseases.
Jacobson MA; Mills J; University of California, San Francisco.
The pathogenic importance of cytomegalovirus ( CMV ) infection in AIDS-associated pneumonitis is controversial. Uncertainty regarding the significance of CMV isolation from pulmonary secretions of AIDS patients results in part
Kukain RA; Nagaeva LI; Kalnberza IV; Ose VP; Mamaeva SE
The electron microscopic examinations of the short-term cultures of mononuclear cells from patients with T-cell acute lymphoblastic leukemia were conducted for the detection of viral particles. The viral particles which correspond in their morphology to C type retroviruses are observed in the intercellular space of th
Oncogenicity for rabbits of lymphotropic herpesvirus of M. arctoides (HVMA) isolated by us earlier from lymphoid cells of lines MAL-1-3 has been shown in the course of studies. Inoculation of animals both with HVMA-containing cells and cell-free virus caused the development of generalized malignant lymphomas of prolym
Uchida T; Institute for Molecular and Cellular Biology, Osaka University,; Japan.
Proteins with molecular weights of up to 500K can be enclosed in erythrocyte ghosts by exposing the ghosts to hypotonic solution containing these proteins. The proteins can then be introduced into recipient cells by fusing the ghosts with the cells using HVJ, PEG, or influenza virus. Some applications of this method a
Spiller RC; Lovell D; Silk DB; Department of Gastroenterology, Central Middlesex Hospital,; London.
Recent reports of cytomegalovirus associated colonic and oesophageal ulceration in immunosuppressed patients infected with the human immunodeficiency virus, have focused attention on the possibility that viral infections may in some cases be the initial insult which leads in suscep
Webster AD; Spickett GP; Thomson BJ; Farrant J; Division of Immunological Medicine, Clinical Research Centre,; Harrow, Middlesex, U.K.
Viral infections that occur in patients with primary immunodeficiencies are summarized. These viral infections include: Echovirus, poliovirus, varicella zoster, non-A non-B hepatitis and hepatitis B. Cases of X-linked lymphoproliferative syndrome associated with Epstein-Barr virus infection and congenital rubella synd
Ullman B; Coons T; Rockwell S; McCartan K; Department of Biochemistry, Oregon Health Sciences University,; Portland 97201.
In order to analyze the cellular determinants that mediate the action of 2 ,3 -dideoxycytidine, the growth inhibitory and cytotoxic effects and the metabolism of the dideoxynucleoside were examined in wild type human CEM T lymphoblasts and in mutant populations of CEM cells that were genetically deficient in either nu
Huang SS; Huang JS; E.A. Doisy Department of Biochemistry, St. Louis University; School of Medicine, Missouri 63104.
In cells transformed by either v-sis or c-sis, the majority of the newly synthesized platelet-derived growth factor (PDGF) receptors fail to reach the cell surface and are rapidly degraded. This rapid turnover (t1/2 less than 30 min) appears to result from interaction of the sis gene product with the PDGF receptor in
A new double-label immunocytochemical method detects JC virus (JCV) early (T-antigen) and late (capsid) proteins simultaneously in cryostat sections of progressive multifocal leukoencephalopathy (PML) brain tissue from both acquired immunodeficiency syndrome (AIDS) and non-AIDS patients. T-antigen is detected with a m
Milburn PB; Brandsma JL; Goldsman CI; Teplitz ED; Heilman EI; Department of Dermatology, State University of New York Health; Science Center, Brooklyn 1203-2098.
A patient with acquired immunodeficiency syndrome developed widespread verrucous lesions on the hands, feet, and penis. Histologic analysis revealed typical changes of verruca vulgaris and, from several sites, a transformation toward squamous cell carcinoma. Southern blot analysis of deoxyribonucleic acid from penile
Yetter RA; Buller RM; Lee JS; Elkins KL; Mosier DE; Fredrickson TN; Morse HC 3d; Laboratory of Immunopathology, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892.
Mice depleted in vivo of CD4+ Th cells by treatment with mAb GK1.5 were found to be resistant to the lymphoproliferative/immunodeficiency disease (MAIDS) induced in intact mice by infection with the mixture of LP-BM5 murine leukemia viruses. Depleted mice did not develop lymphadenopathy or splenomegaly, had normal ser
J Med Virol. 1988 May;25(1):17-26. Unique Identifier : AIDSLINE MED/88316238
Mathiesen T; Sonnerborg A; von Sydow M; Gaines H; Wahren B; Department of Virology, Karolinska Hospital, Stockholm, Sweden.
Cerebrospinal fluid (CSF) and serum samples from 17 patients seropositive for the human immunodeficiency virus (HIV) were analysed for specific IgG1-4 against HIV and cytomegalovirus ( CMV ). Measles IgG was studied as a refere
A variety of clinical syndromes, including AIDS and neurological disorders, may follow as a consequence of infection with the human immunodeficiency virus type 1 (HIV-1). It is not yet clear, however, to what extent the destruction of lymphocytes and neural cells associated with these conditions is caused by adverse i
Yu XF; Ito S; Essex M; Lee TH; Department of Cancer Biology, Harvard University School of Public; Health, Boston, Massachusetts 02115.
The genomic organization of HIV-1 and the family of HIV-2 and SIV viruses is similar. However, there is an open reading frame, orf-x, that is present in HIV-2 and SIV, but not in HIV-1. The extent of protein sequence conservation in orf-x between HIV-2ROD and SIVMAC suggests that this open reading frame encodes a gene
Brady MT; Reiner CB; Singley C; Roberts WH 3d; Sneddon JM; Department of Pediatrics, Ohio State University, Columbus.
Cardiac involvement in patients with acquired immunodeficiency syndrome (AIDS) is being reported with increasing frequency, although the factors responsible for the cardiac abnormalities are rarely identified. We report a case of sudden and unexpected death of an infant with AIDS in whom histologic and virologic studi
Proc Natl Acad Sci U S A. 1988 Sep;85(17):6297-300. Unique Identifier : AIDSLINE MED/88320429
Frankel AD; Chen L; Cotter RJ; Pabo CO; Department of Molecular Biology and Genetics, Johns Hopkins; University School of Medicine, Baltimore, MD 21205.
We have synthesized an 18-amino acid peptide that contains the cysteine-rich region of the tat protein from human immunodeficiency virus. Previous experiments in vitro with the intact tat protein have shown that these cysteines serve as metal ligands, causing tat to form metal-linked dimers. Ultraviolet absorption spe
Proc Natl Acad Sci U S A. 1988 Sep;85(17):6543-6. Unique Identifier : AIDSLINE MED/88320477
Nygren A; Bergman T; Matthews T; Jornvall H; Wigzell H; Department of Immunology, Karolinska Institutet, Stockholm,; Sweden.
125I-labeled gp120 (120-kDa envelope glycoprotein) from the BH10 isolate of human immunodeficiency virus is cleaved to a limited extent with the glutamate-specific protease from Staphylococcus aureus. After disulfide bond reduction, fragments with approximate molecular masses of 95, 60, 50, and 25 kDa are produced. Te
Proc Natl Acad Sci U S A. 1988 Sep;85(18):6968-72. Unique Identifier : AIDSLINE MED/88320557
Matsuda Z; Chou MJ; Matsuda M; Huang JH; Chen YM; Redfield R; Mayer K; Essex M; Lee TH; Department of Cancer Biology, Harvard University School of Public; Health, Boston, MA 02115.
Eight coding regions designated gag, pol, env, sor, R, tat, art/trs, and 3 orf have been identified in the genome of the human immunodeficiency virus type 1 (HIV-1). Several other open reading frames have the potential to encode additional viral proteins. In this study, we show that HIV-1 has another coding sequence
el-Labban N; Rindum J; Nielsen H; Pindborg JJ; Institute of Dental Surgery, Eastman Dental Hospital, London, UK.
Hairy leukoplakia is often the first manifestation of an HIV infection. In the present study we have investigated the ultrastructural features of hairy leukoplakia in two HIV seropositive male homosexual patients. Ultrastructurally EBV particles were found in the upper prickle and keratinized epithelial cells, whereas
About half of patients with acquired immune deficiency syndrome (AIDS) have an associated pulmonary disease which is more often due to infections than to tumors. Rapid diagnosis is important, especially in Pneumocystis carinii pneumonia, since the prognosis depends on early treatment. A patient in good condition may b
Ann Neurol. 1988 Jul;24(1):79-84. Unique Identifier : AIDSLINE MED/88325300
Simpson DM; Bender AN; Department of Neurology, Mount Sinai Medical Center, New York, NY; 10029.
Neuromuscular disorders reported in association with human immunodeficiency virus (HIV) infection include several forms of peripheral neuropathy and polymyositis. We report 11 patients with HIV-associated myopathy. Five patients with acquired immunodeficiency syndrome
So YT; Holtzman DM; Abrams DI; Olney RK; Department of Neurology, University of California, San Francisco; 94143.
We prospectively studied 40 hospitalized patients who had well-established diagnoses of acquired immunodeficiency syndrome. Patients with confounding risk factors for neuropathy were excluded; none of the study patients had known vitamin deficiency, alcoholism, or any metabolic, drug, or toxic factor. Clinical and ele
Daikos GL; Pulido J; Kathpalia SB; Jackson GG; Department of Medicine, University of Illinois College of; Medicine, Chicago 60612.
The efficacy and toxicity of ganciclovir given by intravenous or intravenous plus intravitreal injection were studied in nine patients with cytomegalovirus ( CMV ) retinitis; seven with AIDS and two with drug induced immunodefi
Orellana J; Teich SA; Winterkorn JS; Mathur-Wagh U; Handwerger S; Schlamm H; Malamud SC; Yancovitz SR; Cederberg DM; Mildvan DS; Department of Ophthalmology, Beth Israel Medical Center, New; York, New York 10003.
Six patients (11 eyes) with virologically confirmed cytomegalovirus ( CMV ) retinitis involving the posterior pole of the eye were treated with a new drug, ganciclovir. Treatment with intravenous ganciclovir consistently halted
C R Acad Sci III. 1988;307(2):53-8. Unique Identifier : AIDSLINE MED/88327426
Gessain A; Saal F; Vilette D; Lasneret J; Giron ML; Sigaux F; Gout O; Emanoil-Ravier R; de The G; Peries J; Institut de Recherches sur les Maladies du Sang, Laboratoire de; Virologie des Leucemies, L.O.I.-C.N.R.S., Hopital Saint-Louis,; Paris.
HTLV-I, the causative agent of Adult T cell Leukemia, has recently been found to be associated with chronic neuromyelopathies common in tropical areas and in Japan . We report here the establishment of a lymphoid T cell line from peripheral blood lymphocytes of a patient with Tropica
Congenital infection is uncommon and the cause of only a small proportion of handicap seen in children but some infections may be preventable or even treatable. As an example, the congenital rubella syndrome first described in the 1940s is preventable by use of the vaccine but cases still occur. It is hoped that with
Levin RH; Bolinger AM; Division of Clinical Pharmacy, School of Pharmacy, University of; California, San Francisco.
Two cases of Mycobacterium avium-intracellulare complex (MAC) infections are described, and the diagnosis, clinical features, and management of MAC infections are reviewed. In case 1, a four-year-old boy was diagnosed as having both acquired immunodeficiency syndrome (AIDS) and disseminated MAC infection. He was treat
Chander P; Agarwal A; Soni A; Kim K; Treser G; Department of Pathology, New York Medical College, Valhalla; 10595.
Tubuloreticular inclusions (TRI) and cylindrical confronting cisternae (CCC) are present in cells of patients with the acquired immunodeficiency syndrome (AIDS) and have also been detected in the kidneys of individuals with AIDS and heavy proteinuria. We examined renal biopsy tissue from 13 patients with proteinuria a
Stirk PR; Griffiths PD; Department of Virology, Royal Free Hospital School of Medicine,; Hampstead, London, U.K.
Conventional cell culture (CCC), an immunofluorescent assay for the rapid detection of CMV-induced early antigens (DEAFF) in infected fibroblasts and an immunofluorescent assay for the detection of CMV-infected cells obtained directly from clinical material were compared prospectively for their ability to detect CMV i
Nam SH; Kidokoro M; Shida H; Hatanaka M; Institute for Virus Research, Kyoto University, Japan.
The biological activity encoded in the putative protease gene (pro) of human T-cell leukemia virus type I was investigated by using a vaccinia virus expression vector. The 53-kilodalton gag precursor polyprotein was processed into the mature p19, p24, and p15 gag proteins when the gag and protease-coding sequence was
Jeang KT; Shank PR; Rabson AB; Kumar A; Laboratory of Molecular Virology, National Cancer Institute,; Bethesda, Maryland 20892.
The human immunodeficiency virus tat protein is a strong trans-activator of the expression of mRNAs originating from the viral long terminal repeat. We have expressed the first 72 amino acids (coding exon 1) of this protein in eucaryotic Spodoptera frugiperda SF9 cells by using a baculovirus vector, Autographa califor
Human CD4 is the receptor for the gp120 envelope glycoprotein of human immunodeficiency virus and is essential for virus entry into the host cell. Sequence analysis of CD4 has suggested an evolutionary origin from a structure with four immunoglobulin-related domains. Only the two NH2-terminal domains are required to m
Chaudhary VK; Mizukami T; Fuerst TR; FitzGerald DJ; Moss B; Pastan I; Berger EA; Laboratory of Molecular Biology, National Cancer Institute,; Bethesda, Maryland 20892.
It is projected that in the absence of effective therapy, most individuals infected with human immunodeficiency virus (HIV) will develop acquired immune deficiency syndrome (AIDS) and ultimately succumb to a combination of opportunistic microbial infections, malignancies and direct pathogenic effects of the virus. Ant
Kornfeld H; Cruikshank WW; Pyle SW; Berman JS; Center DM; Pulmonary Center, Boston University School of Medicine, Boston,; Massachusetts 02118.
Cell activation by phytohaemagglutinin, phorbol ester and by the supernatant of phytohaemagglutinin-stimulated peripheral blood mononuclear cells induces the expression and cytopathic effects of latent human immunodeficiency virus type-1 (HIV-1) in vitro. The lymphocyte surface protein CD4 has been identified as a rec
Ballard DW; Bohnlein E; Lowenthal JW; Wano Y; Franza BR; Greene WC; Howard Hughes Medical Institute, Duke University Medical Center,; Durham, NC 27710.
Jurkat T cell lines constitutively expressing Tax, the 40-kilodalton transactivator protein of human T lymphotropic virus type I (HTLV-I), were used to investigate the mechanism by which this viral product deregulates the expression of the interleukin-2 receptor alpha gene (IL-2R alpha, Tac). Transfection of deleted f
Herrera MI; Santa Maria I; de Andres R; Najera R; Centro Nacional de Microbiologia, Virologia e Inmunologia; Sanitarias, Madrid, Spain.
An application of high resolution scanning/transmission electron microscopy (STEM) and gold-labelling techniques for the rapid detection of human immunodeficiency virus (HIV) in infected cells has been developed. Experimental in vitro studies for detecting two HIV structural proteins, gp41 and p17, were performed foll
We have studied the serological relationship among the human immunodeficiency virus type 1 (HIV-1), and three simian immunodeficiency viruses (SIV). SIVagm was isolated from African green monkeys (Cercopithecus aethiops), and compared with the previously described isolates of SIVmac from a rhesus macaque (Macaca mulat
Cancer Res. 1988 Sep 1;48(17):5042-4. Unique Identifier : AIDSLINE MED/88310875
Wang CH; Chen CJ; Hu CY; You SL; Chu CT; Chou MJ; Essex M; Blattner WA; Liu CH; Yang CS; Department of Internal Medicine, National Taiwan University; College of Medicine, Taipei, Republic of China.
The epidemiological characteristics of human T-cell lymphotropic virus type I infection in Taiwan have been explored by an island-wide community-based survey, which was carried out among residents in 19 townships and metropolitan pr
Leor J; Langevitz P; Trau H; Schinder EO; Douer D; Ben-Bassat I; Department of Medicine F, Chaim Sheba Medical Center,; Tel-Hashomer, Israel.
Human T-cell lymphotrophic virus Type I (HTLV-I)-associated adult T-cell leukemia/lymphoma (ATL) is a relatively new clinical entity. The disease is endemic in southwestern Japan , the Caribbean basin, the southeastern United States and Africa. We rep
Croxson S; Mildvan D; Mathews H; Poiesz BJ; Department of Medicine, Beth Israel Medical Center, New York, New; York 10003.
Replication of human immunodeficiency virus (HIV) may be initiated in infected lymphocytes by antigenic or mitogenic stimulation. A soluble protein derived from an invasive strain of Entamoeba histolytica (amoebic antigen [AA]) was used to study the lymphoblastic responses of T lymphocytes derived from 8 HIV-seronegat
Chen CJ; Hwang SJ; Fan KY; Chang SA; Chang YH; Wang SR; Liu WT; Liaw YF; Chai CY; Chang R; et al; Institutes of Public Health, National Taiwan University College; of Medicine, Taipei, Taiwan, Republic of China.
Yoshida S; Mizuguchi Y; Mizue K; Sakamoto H; Urabe S; Department of Microbiology, School of Medicine, University of; Occupational and Environmental Health, Kitakyushu, Japan.
Prevalence of hepatitis B (HB) markers, antibodies to human T cell leukemia virus (HTLV-1) and antibodies to human immune deficiency virus 1 (HIV-1) in prostitutes working in Fukuoka city were studied. Sera were collected from 237 prostitutes during January-September, 1986. Among them, 9 (3.8%) were HB virus surface-a
Mayo Clin Proc. 1988 Sep;63(9):869-75. Unique Identifier : AIDSLINE MED/88317744
Larson CJ; Taswell HF; Division of Laboratory Medicine, Mayo Clinic, Rochester, MN; 55905.
Human T-cell leukemia (or T-lymphotropic) virus type I (HTLV-I) is a human exogenous infectious retrovirus of the family Retroviridae. This virus has been associated with adult T-cell leukemia and endemic myelopathies (tropical spastic paraparesis and HTLV-I associated myelopathy). HTLV-I is transmitted by sexual cont
Laure F; Courgnaud V; Rouzioux C; Blanche S; Veber F; Burgard M; Jacomet C; Griscelli C; Brechot C; INSERM U75, Centre Hospitalier Universitaire Necker, Paris,; France.
The polymerase chain reaction (PCR) assay was used to investigate the possibility of HIV1 DNA detection in uncultured peripheral blood mononuclear cells from newborn infants and children of HIV-infected mothers. HIV1 DNA sequences were detected in mononuclear cells of six of fourteen symptom-free newborn infants of se
Hart C; Schochetman G; Spira T; Lifson A; Moore J; Galphin J; Sninsky J; Ou CY; AIDS Program, Centers for Disease Control, Atlanta, Georgia.
The polymerase chain reaction (PCR) and reverse transcription were used to assess human immunodeficiency virus type 1 (HIV1) RNA expression in peripheral blood mononuclear cell samples from seropositive subjects. HIV RNA was detected from seropositive subjects who had no symptoms, lymphadenopathy syndrome, and acquire
Morikawa K; Kuroda M; Tofuku Y; Uehara H; Akizawa T; Kitaoka T; Koshikawa S; Sugimoto H; Hashimoto K; Department of Clinical and Laboratory Medicine, Fukui Medical; School, Japan.
The southwestern region of Japan is known as a very high endemic area of human T-cell lymphotropic virus type 1 (HTLV-1), the etiologic agent for adult T-cell leukemia (ATL) and probable causative agent for tropical spastic paraparesis and its Japanese version, HTLV-1-associated mye
Dumas M; Giordano C; Ndiaye IP; Hugon J; Vallat JM; Sonan T; Institut d'Epidemiologie Neurologique et de Neurologie; Tropicale, Faculte de Medecine, Limoges.
Since the beginning of this century, the concept of tropical neuromyelopathy (T. N. M.) was progressively elaborated in tropical areas. This disorder is constituted by three main clinical syndromes (e.g.: polyneuropathy, spastic paraplegia, ataxia). Abnormal clinical, electrophysiological and pathological features, ob
Ollenschlager G; Jansen S; Schindler J; Rasokat H; Schrappe-Bacher M; Roth E; Department of Medicine II, University of Cologne, F.R.G.
We measured the free amino acids in plasma of 58 patients with HIV infection and in six persons in the risk group. The HIV+ patients had significantly increased concentrations of arginine, phenylalanine, and glutamate in comparison with both age- and sex-matched controls and the members of the risk group. Glutamate co
Jackson GG; Perkins JT; Rubenis M; Paul DA; Knigge M; Despotes JC; Spencer P; Department of Medicine, University of Illinois, College of; Medicine, Chicago.
Infusions of 55-500 ml plasma from one of two donors selected for high anti-p24 antibody titre and neutralising capacity were given to six patients with advanced AIDS. Human immunodeficiency virus (HIV) antigenaemia cleared immediately and the recipients serum acquired the HIV antibody profile of the donor together w
Lang JM; Touraine JL; Trepo C; Choutet P; Kirstetter M; Falkenrodt A; Herviou L; Livrozet JM; Retornaz G; Touraine F; et al; Hopital Hautepierre, Strasbourg, France.
83 patients with human immunodeficiency virus (HIV) infection (CDC groups II, III, or IV-A) were randomised in a crossover trial of sodium-diethyldithiocarbamate (ditiocarb sodium, Imuthiol ) (10 mg/kg body weight given orally once a week) against placebo. Each arm of the trial lasted 16 weeks. The disease did not pr
Itoyama Y; Minato S; Goto I; Okochi K; Yamamoto N; Department of Neurology, Kyushu University, Fukuoka, Japan.
We studied the serum antibody titers to Epstein-Barr virus (EBV) in 11 patients with HTLV-I-associated myelopathy (HAM). HAM patients showed significant increases in IgG antibodies to EBV-capsid antigen (VCA) and -early antigen (EA) and in VCA-specific IgA compared with 25 seronegative subjects. However, there were no
Ferguson CM; Department of Surgery, Emory University School of Medicine,; Atlanta, Georgia.
From 1 January 1984 to 31 August 1987, 11 patients underwent splenectomy for treatment of thrombocytopenia related to human immunodeficiency virus (HIV). Six of the patients had been previously treated with prednisone, five of whom showed some response. None of those who responded to the prednisone had a sustained res
STUDY OBJECTIVE: To determine the features of pulmonary involvement in patients with tropical spastic paraparesis associated with human T-cell lymphotropic virus type 1. DESIGN: Nonrandomized prospective case series. SETTING: Tertiary care units in two university medical centers. PATIENTS: Consecutive sample of 21 pat
Vittecoq D; Woerle R; Barre-Sinoussi F; Chermann JC; Department of Immunology, Hopital Necker, Paris, France.
Ammonium tungsto antimoniate (HPA 23) is a potent inhibitor of nucleic acid polymerases and reverse transcriptases of retroviruses. Its in vivo activity as an HIV inhibitor was previously published. However, its clinical use is limited by pharmacological parameters (short half-life and intravenous administration) and
Plaeger-Marshall S; Haas A; Clement LT; Giorgi JV; Chen IS; Quan SG; Gatti RA; Stiehm ER; Department of Pediatrics, UCLA School of Medicine, Los Angeles,; California 90024.
Class II antigens encoded by genes of the major histocompatibility complex (MHC) are expressed by a variety of cell types and have a vital role in the cellular interactions required for an effective immune response. We have analyzed the regulation of HLA-DR, DP, and DQ class II antigen expression on cells of different
Krown SE; Real FX; Vadhan-Raj S; Oettgen HF; Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Interferons are natural proteins with important regulatory functions. Impairment of their production may help to explain many of the immunologic abnormalities and disease susceptibilities of AIDS patients, while excessive production of an unusual type of interferon may explain some of the systemic symptoms associated
Nature. 1988 Aug 25;334(6184):706-8. Unique Identifier : AIDSLINE MED/88318926
Berzofsky JA; Bensussan A; Cease KB; Bourge JF; Cheynier R; Lurhuma Z; Salaun JJ; Gallo RC; Shearer GM; Zagury D; Metabolism Branch, National Cancer Institute, Bethesda, Maryland; 20892.
T-lymphocyte immunity is likely to be an important component of the immune defence against the AIDS virus, because helper T cells are necessary for the antibody response as well as the cytotoxic response. We have previously predicted two antigenic sites of the viral envelope protein gp120 likely to be recognized by T
Zahm P; Hofschneider PH; Koshy R; Max-Planck-Institut fur Biochemie, Martinsried bei Munchen,; Federal Republic of Germany.
We report here on a transactivating function of HBV DNA. The effect is shown by stimulation of transient expression of pSV2cat DNA in cotransfected human liver CCL13 cells. Transfection experiments with plasmid constructs containing different HBV DNA fragments and Northern analyses of RNA from cells transfected with t
Proc Natl Acad Sci U S A. 1988 Aug;85(16):6132-6. Unique Identifier : AIDSLINE MED/88320395
Baba M; Pauwels R; Balzarini J; Arnout J; Desmyter J; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
The sulfated polysaccharides dextran sulfate and heparin have proved to be potent and selective inhibitors of human immunodeficiency virus type 1 (HIV-1) in vitro. Dextran sulfate (Mr 5000) and heparin (Mr 15,000) completely protected MT-4 cells against HIV-1-induced cytopathogenicity at a concentration of 25 microgra
Proc Natl Acad Sci U S A. 1988 Sep;85(18):6939-43. Unique Identifier : AIDSLINE MED/88320551
Minassian AA; Kalyanaraman VS; Gallo RC; Popovic M; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, MD 20892.
Four mouse monoclonal antibodies were developed after immunization with one human immunodeficiency virus (HIV) type 2 isolate and were tested for reactivity with different HIV-1, HIV-2, and simian immunodeficiency virus (SIV) isolates in an immunofluorescence assay and by immunological blot analysis. One of them, an a
The results of HIV virus isolation from patient A. T., resident of Central Africa, are discussed, in whom Kaposi sarcoma was diagnosed clinically and histologically, and immunological examinations revealed the acquired immunodeficiency syndrome (AIDS). Cocultivation of the peripheral blood leukocytes of the patient wi
The possibility of optimizing the conditions for the cultivation of cells producing human immunodeficiency virus (HIV) was explored. The stimulating effect on the cell cultures of interleukin-2 and specific anti-interferon antibodies was examined. The individual use of interleukin-2 or anti-interferon antibody prepara
Reed KD; Fowler CB; Brannon RB; Department of Pathology, Wilford Hall, United States Air Force; Medical Center, Lackland Air Force Base, Texas 78236-5300.
Hairy leukoplakia (HL) is a newly recognized virus-associated lesion of oral mucosa that occurs in persons infected with human immunodeficiency virus. Studies have demonstrated Epstein-Barr virus within epithelial cells of HL. The authors examined 12 cases of HL by transmission electron microscopy to compare the use o
Can Med Assoc J. 1988 Oct 1;139(7):635-9. Unique Identifier : AIDSLINE MED/88327655
Shepherd FA; Evans WK; Garvey B; Read SE; Klein M; Fanning MM; Coates R; Department of Medicine, Toronto General Hospital, Ont.
Thirteen men with a median age of 37 (range 28 to 46) years who had extensive Kaposi s sarcoma associated with acquired immune deficiency syndrome (AIDS) were treated with combination chemotherapy and alpha-interferon. Four patients had stage III disease and nine had stage IV disease (one with pulmonary and eight with
Ono K; Nakane H; Barre-Sinoussi F; Chermann JC; Laboratory of Viral Oncology, Aichi Cancer Center Research; Institute, Nagoya, Japan.
The 21-tungsto-9-antimoniate ammonium salt (HPA23), known as an antiviral agent, has been shown to be a potent inhibitor of both human and murine DNA polymerase alpha and murine DNA polymerase gamma. HPA23 inhibited the activity of DNA polymerase alpha in noncompetitive fashion with respect to either deoxynucleotide s
McHaffie JG; Kruger L; Clemo HR; Stein BE; Department of Physiology, Medical College of Virginia, Richmond; 23298.
Corticothalamic and corticotectal projections from the anterior ectosylvian sulcus (AES) in neonatal cats were studied with anterograde and retrograde neuroanatomical techniques. When the injection site was relatively restricted to the sulcal walls and fundus of the rostral AES (i.e., the SIV cortex), heavy ipsilatera
Pauza CD; Galindo J; Richman DD; Developmental Biology Laboratory, Salk Institute for Biological; Studies, San Diego, California 92138-9216.
Stringent control of human immunodeficiency virus (HIV) replication was observed in the human monoblastoid cell line U937. A low-multiplicity infection of these cells by the LAV1 strain of HIV was productive for 2.5 days; then virus replication became restricted and no further evidence of virion production was observe
Tisdale M; Ertl P; Larder BA; Purifoy DJ; Darby G; Powell KL; Wellcome Research Laboratories, Beckenham, Kent, United Kingdom.
We describe the production of eight monoclonal antibodies reactive with human immunodeficiency virus type 1 reverse transcriptase (RT) by immunization of mice with purified recombinant RT. These antibodies were found to react with one or the other of two regions of the enzyme and were found to be useful in immunodefic
Linsley PS; Ledbetter JA; Kinney-Thomas E; Hu SL; Oncogen, Seattle, Washington 98121.
Monoclonal antibodies (MAbs) to defined peptide epitopes on gp120 from human immunodeficiency virus type 1 were used to investigate the involvement of their epitopes in gp120 binding to the CD4 receptor. Recombinant vaccinia viruses were constructed that expressed either full-length gp120 (v-ED6), or a truncated gp120
Takeuchi Y; Nagumo T; Hoshino H; Department of Hygiene, Gunma University School of Medicine,; Japan.
The fidelity of DNA synthesis by reverse transcriptases from human immunodeficiency virus and other retroviruses was compared by measuring the rates of misincorporation of dCMP in the place of TMP in cell-free DNA synthesis with polyadenylic acid as the template. The fidelity of human immunodeficiency virus reverse tr
Zaia JA; Rossi JJ; Murakawa GJ; Spallone PA; Stephens DA; Kaplan BE; Eritja R; Wallace RB; Cantin EM; City of Hope National Medical Center, Duarte, California.
Antiviral effects were characterized for two oligodeoxyribonucleoside methylphosphonates synthesized in an antisense (3 -TCTTAACC-5 ) or a sense (5 -AGAATTGG-3 ) orientation, based on the RNA sequence of the first splice acceptor site of the tat-3 gene of human immunodeficiency virus (HIV) (5 ...AGAAUUGG...3 ). The de
Klin Wochenschr. 1988 Jun 15;66(12):533-9. Unique Identifier : AIDSLINE MED/88333663
von Herbay A; Otto HF; Pathologisches Institut, Universitat Heidelberg.
Twenty-two patients with Whipple s disease are reviewed (21 male, 1 female; mean age 49.3 years). All but one were diagnosed by small intestinal biopsy. The most frequent clinical symptoms at diagnosis were weight loss (14/21 patients), diarrhea (13/21), arthralgias (13/21), cramping abdominal pain (11/21), and skin p
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