INTRODUCTION OF INBRED RABBITS FOR RESEARCH ON VIRAL TUMORS NLM AIDSLINE Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

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INTRODUCTION OF INBRED RABBITS FOR RESEARCH ON VIRAL TUMORS

Cancer Cells; 5:367-71 1987. Unique Identifier : AIDSLINE ICDB/88645281
Seto A; Fu N; Matsuda S; Eguchi T; Miyoshi I; Ito Y; Dept. of Microbiology, Faculty of Medicine, Kyoto Univ., Kyoto; 606, Japan

Abstract: Two experimental systems of viral tumors, Shope papilloma and adult T-cell leukemia, were established in inbred rabbit strains in which lymphocytic reactions and the feasibility of cell transfer were studied. Peripheral blood T lymphocytes of an inbred rabbit were transformed by human T-lymphotropic virus type I (HTLV-I), and the transformed cells were injected into rabbits. A single inoculation of the transformed cells induced antibodies against the viral antigens in inbred rabbits but not in F1 hybrids. These findings suggest either that the transformed cells are more immunogenic in the parent strain than in the hybrids or that HTLV-1 infection is more easily established in the parent strain than in the hybrids. Shope papillomas induced in the inbred rabbits did not regress spontaneously, whereas tumor regression was observed in 42% of random-bred rabbits. Dispersed papilloma cells from inbred rabbits were transplantable into normal and papilloma-bearing animals of the same strain. This experimental system may be valuable for immunological analyses of the regression mechanism; such analyses have long been hampered by the lack of available inbred rabbits. (23 Refs)
Keywords: Animal Cell Line, Transformed *Cell Transformation, Neoplastic *Cell Transformation, Viral Gene Expression Regulation HTLV-BLV Infections/*GENETICS HTLV-BLV Viruses/*GENETICS Inbreeding Lymphocyte Transformation Papillomavirus/*GENETICS Rabbits Tumor Virus Infections/*GENETICS MEETING PAPER

KWDanimalcellline,transformedKWDcelltransformation,neoplasticKWDcelltransformation,viralgeneexpressionregulationhtlv-blvinfections/KWDgeneticshtlv-blvviruses/KWDgeneticsinbreedinglymphocytetransformationpapillomavirus/KWDgeneticsrabbitstumorvirusinfections/KWDgeneticsmeetingpaper
880830
M8880543

Copyright © 1988 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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