Heterosexual transmission of human immunodeficiency virus: association with severe depletion of T-helper lymphocytes in men with hemophilia. NLM AIDSLINE Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

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Heterosexual transmission of human immunodeficiency virus: association with severe depletion of T-helper lymphocytes in men with hemophilia.

AIDS Res Hum Retroviruses. 1987;3(4):355-61. Unique Identifier : AIDSLINE MED/88192934
Goedert JJ; Eyster ME; Biggar RJ; Blattner WA; Environmental Epidemiology Branch, National Cancer Institute,; Bethesda, MD 20892.

Abstract: We evaluated risk factors for human immunodeficiency virus (HIV) seropositivity in the wives/female sexual partners of hemophiliacs. One of the 6 seropositive women has developed the acquired immunodeficiency syndrome (AIDS). At least three of the others seroconverted during 1985-86, after more than four years of regular sexual contact with a seropositive hemophiliac. HIV seropositivity was present in at least 5 (50%) of the 10 female partners of hemophiliacs with severe depletion of T-helper cells (less than 100/microliters), including 3 (43%) of the 7 female partners of hemophiliacs with AIDS. All 4 HIV seropositive women with available data had vaginal intercourse without a condom, but risk of seropositivity did not appear to be affected by the frequency of vaginal intercourse or by hysterectomy. Other sexually transmitted diseases, anal intercourse, or vaginal intercourse during menstrual periods were not necessary for HIV infection. These data suggest that heterosexual transmission of HIV can occur during routine vaginal intercourse but that it usually does not occur until the hemophiliac has severe immune deficiency late in the course of HIV infection.
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS/IMMUNOLOGY/ *TRANSMISSION Antibodies, Viral/ANALYSIS Female Hemophilia/COMPLICATIONS/*IMMUNOLOGY Human HIV/IMMUNOLOGY HIV Seropositivity Male *Sex Behavior Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes/*IMMUNOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/complications/immunology/KWDtransmissionantibodies,viral/analysisfemalehemophilia/complications/KWDimmunologyhumanhiv/immunologyhivseropositivitymaleKWDsexbehaviorsupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes/KWDimmunologyjournalarticle
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Copyright © 1988 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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