Human immunodeficiency virus (HIV) infection in children. NLM AIDSLINE Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

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Human immunodeficiency virus (HIV) infection in children.

Hematol Oncol Clin North Am. 1987 Sep;1(3):381-95. Unique Identifier : AIDSLINE MED/88197889
Ryan B; Connor E; Minnefor A; Desposito F; Oleske J; University of Medicine and Dentistry of New Jersey, Newark.

Abstract: HIV infection in pediatric patients is a multisystem chronic disease that manifests as a clinical spectrum from asymptomatic infection through symptomatic infection with opportunistic infections and malignancies. The hematopoietic system is involved early in the systemic manifestations of this disease. The hematologic abnormalities seen are most probably a reflection of persistent viral infection, inflammation, and immune dysregulation, and may be complicated by secondary infections, chronic disease, drug toxicities, and nutritional deficiencies. Anemia and lymphopenia are commonly found in adult AIDS patients. Although both are also seen in pediatric patients, lymphopenia is much less common. Atypical lymphocytes with plasmacytoid characteristics have been identified in both adults and children. Pediatric bone marrow evaluation has shown an increase in plasma cells and plasmacytoid lymphocytes. Besides these findings, adult marrow findings include an increase in reticulum and lymphocytes appearing in a diffuse or aggregate pattern.
Keywords: *Acquired Immunodeficiency Syndrome/COMPLICATIONS/EPIDEMIOLOGY/ IMMUNOLOGY/PHYSIOPATHOLOGY Bone Marrow Diseases/ETIOLOGY/PATHOLOGY Child Child, Preschool Hematologic Diseases/BLOOD/ETIOLOGY Human Infant Infant, Newborn Neoplasms/ETIOLOGY Opportunistic Infections/ETIOLOGY JOURNAL ARTICLE REVIEW REVIEW, MULTICASE


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Copyright © 1988 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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