Histoplasmosis in patients at risk for the acquired immunodeficiency syndrome in a nonendemic setting. NLM AIDSLINE Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

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Histoplasmosis in patients at risk for the acquired immunodeficiency syndrome in a nonendemic setting.

Chest. 1988 May;93(5):916-21. Unique Identifier : AIDSLINE MED/88195520
Salzman SH; Smith RL; Aranda CP; Bellevue Chest Service, New York Veterans Administration Medical; Center, New York.

Abstract: We reviewed 18 cases of histoplasmosis in patients at risk for the acquired immunodeficiency syndrome seen at two New York City hospitals in the past 3 1/2 years. Seventeen patients were Hispanic, including 13 born in Puerto Rico and three in South America. Clinical presentation was subacute, with high fever, weight loss, and mild respiratory symptoms with well-maintained gas exchange. Five patients had normal chest roentgenograms. The most common chest roentgenographic abnormality was diffuse small nodules. A rapid diagnosis was established histologically in 72 percent of patients, most commonly by transbronchial lung biopsy; cultures were positive in 94 percent of patients while serology was positive in five of six patients. Mycobacterium tuberculosis was a concurrent, often unrecognized, pathogen in six cases. Most patients responded to amphotericin therapy. Histoplasmosis may represent an early sign of altered host immunity in the acquired immunodeficiency syndrome.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult Hispanic Americans Histoplasmosis/EPIDEMIOLOGY/*ETIOLOGY Homosexuality Human HIV Seropositivity Lung Diseases, Fungal/EPIDEMIOLOGY/*ETIOLOGY Male Middle Age New York City Puerto Rico/ETHNOLOGY Risk Factors South America/ETHNOLOGY Substance Abuse Tuberculosis, Pulmonary/EPIDEMIOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcomplicationsadulthispanicamericanshistoplasmosis/epidemiology/KWDetiologyhomosexualityhumanhivseropositivitylungdiseases,fungal/epidemiology/KWDetiologymalemiddleagenewyorkcitypuertorico/ethnologyriskfactorssouthamerica/ethnologysubstanceabusetuberculosis,pulmonary/epidemiologyjournalarticle
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M8880475

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