[Diagnostic value of the determination of HIV antigen in enzyme immunoassay] NLM AIDSLINE Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

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[Diagnostic value of the determination of HIV antigen in enzyme immunoassay]

Dtsch Med Wochenschr. 1988 Apr 15;113(15):605-7. Unique Identifier : AIDSLINE MED/88195855
Stute R; Isenberg E; Blutspendezentrale Saarland des Staatlichen Instituts fur; Gesundheit und Umwelt, Saarbrucken.

Abstract: Enzyme-immunoassays (EIA) for HIV antigen and antibodies were performed on 33,076 serum samples during an 11-month period. Prospective analysis involved samples from 21,496 blood donors, 11,086 samples sent in as coming from high-risk persons and 101 samples from AIDS patients, while retrospectively samples from 393 high-risk persons, including a group of homosexuals from New York, were tested. No HIV antigen was found among blood donors, although during the test period seroconversion of one blood donor had been noted. Among 297 persons infected with HIV, 82 sera were positive for HIV antigen, always in combination with HIV antibodies: there was no case positive for HIV antigen but negative for HIV antibodies. The results suggests that at present it is not necessary routinely to test blood donors for HIV antigen by EIA.
Keywords: Acquired Immunodeficiency Syndrome/*DIAGNOSIS Antibodies, Viral/ANALYSIS Antibody Specificity Antigens, Viral/*ANALYSIS Blood Donors Comparative Study English Abstract Evaluation Studies Human HIV/*IMMUNOLOGY HIV Seropositivity/DIAGNOSIS Immunoassay/METHODS Retrospective Studies Risk Factors JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDdiagnosisantibodies,viral/analysisantibodyspecificityantigens,viral/KWDanalysisblooddonorscomparativestudyenglishabstractevaluationstudieshumanhiv/KWDimmunologyhivseropositivity/diagnosisimmunoassay/methodsretrospectivestudiesriskfactorsjournalarticle
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