Cytological and immunoglobulin findings in cerebrospinal fluid of symptomatic and asymptomatic human immunodeficiency virus (HIV) seropositive patients. NLM AIDSLINE Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

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Cytological and immunoglobulin findings in cerebrospinal fluid of symptomatic and asymptomatic human immunodeficiency virus (HIV) seropositive patients.

Infection. 1988;16(1):13-8. Unique Identifier : AIDSLINE MED/88197388
Hagberg L; Forsman A; Norkrans G; Rybo E; Svennerholm L; Department of Infectious Diseases, University of Goteborg.

Abstract: Immunostimulation in the central nervous system (CNS) measured as abnormal intrathecal immunoglobulin production or activated lymphocytes in the cerebrospinal fluid (CSF), was found in 22 of 25 HIV seropositive patients. All of 11 patients with symptomatic HIV infection and nine of 14 asymptomatic patients had an increased IgG index or a Tourtellotte's production number indicating CNS infection. The amount of intrathecal immunoglobulin was not correlated to the severity of disease since five of six AIDS patients had only slightly elevated values, while some patients without AIDS had a high intrathecal immunoglobulin production. Activated lymphocytes and plasma cells in CSF were frequently found in symptomatic HIV patients without AIDS as well as in asymptomatic HIV seropositive patients. Macrophages and activated monocytes were observed in CSF from AIDS patients. The results indicate that HIV has a high neurotropicity and is spread to CNS in all stages of the infection.
Keywords: Acquired Immunodeficiency Syndrome/*CEREBROSPINAL FLUID Adult AIDS-Related Complex/CEREBROSPINAL FLUID Female Human *HIV Seropositivity Male Support, Non-U.S. Gov't JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcerebrospinalfluidadultaids-relatedcomplex/cerebrospinalfluidfemalehumanKWDhivseropositivitymalesupport,non-uKWDsKWDgov'tjournalarticle
880830
M8880469

Copyright © 1988 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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