Rockville, Md. : U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Alcohol Abuse and Alsoholism ; Washington, D.C. ; For sale by the Supt. of Docs., U.S. G.P.O., [1987] iv, 78 p (DHHS publication ; no. (ADM) 87-1513) Unique Identifier : AIDSLINE CAT/8806964
Washington, D.C. : American Psychological Association, c1988 viii, 53 p (Bibliographies in psychology ; no. 2) Unique Identifier : AIDSLINE CAT/8806308
Dessaint AY; Kerby JL; McLean BE
Lists 340 journal articles and dissertations focusing on the psychological and behavioral aspects of AIDS and related complex. Arranged alphabetically by authors. Subject index, title index by classifications.
Bethesda, Md. : U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Library of Medicine, Reference Section ; Washington, D.C. : For sale by the Supt. of Docs., U.S. G.P.O., [1988- v Unique Identifier : AIDSLINE CAT/8806987
Cancer Cells; 5:367-71 1987. Unique Identifier : AIDSLINE ICDB/88645281
Seto A; Fu N; Matsuda S; Eguchi T; Miyoshi I; Ito Y; Dept. of Microbiology, Faculty of Medicine, Kyoto Univ., Kyoto; 606, Japan
Two experimental systems of viral tumors, Shope papilloma and adult T-cell leukemia, were established in inbred rabbit strains in which lymphocytic reactions and the feasibility of cell transfer were studied. Peripheral blood T lymphocytes of an inbred rabbit were transformed by human T-lymphotropic virus type I (HTLV
Antigen activation of T cells stimulates the de novo synthesis and secretion of interleukin-2 ( IL-2 or T-cell growth factor) and the expression of high and low affinity IL-2 receptors. The interaction of IL-2 with its high affinity receptor stimulates cellular prolifer
AIDS and Other Sexually Transmitted Diseases and the Eye. Insler MS, ed. Orlando, FL, Grune and Stratton, Inc., 179 p., 1987.. Unique Identifier : AIDSLINE ICDB/88646863
Anonymous; No affiliation given
The present book discusses current trends in the diagnosis and treatment of sexually transmitted diseases that affect the eye under the following chapter headings: ophthalmia neonatorum, inclusion conjunctivitis, herpes simplex virus, syphilis, viral venereal warts and Molluscum contagiosum, the acquired immunodeficie
Eleventh Annual Cancer Symposium. Scripps Memorial Hospitals Cancer Center, La Jolla, CA, p. 7-12, 1987.. Unique Identifier : AIDSLINE ICDB/88645131
Foon KA; Div. of Hematology/Oncology, Univ. of Michigan Hosp., Ann Arbor,; MI
Interferons (IFNs) are a family of proteins produced by cells in response to a virus, double-stranded RNA, antigens, and mitogens. Although the mechanism of action of IFNs in cancer therapy remains unclear, it is postulated that they work via an antiproliferative activity or by altering the immune system. For example,
AIDS Res Hum Retroviruses. 1987;3(4):363-73. Unique Identifier : AIDSLINE MED/88192935
Rostad SW; Sumi SM; Shaw CM; Olson K; McDougall JK; Department of Pathology, University of Washington, Seattle.
In addition to central nervous system (CNS) opportunistic infections and neoplasms, patients with acquired immunodeficiency syndrome (AIDS) develop unexplained dementia and encephalopathy and degeneration of the white matter. We studied autopsied brains from 20 adult patients who e
Over the past five years, the proportion of AIDS cases among gay and bisexual men in New York City has fallen as the proportion of AIDS cases has risen among IV drug abusers, the major channel of HIV infection to children and heterosexuals in New York City. By 1991, there will be over 40,000 cumulative AIDS cases in N
Stall R; Center for AIDS Prevention Studies, University of California, San; Francisco 94143.
The effort to prevent further HIV infection for high risk populations has been largely limited, in practice, to health education efforts. Prevention policy must utilize techniques which, in combination with health education efforts, works to decrease behaviors which are implicated in HIV transmission. It is argued tha
Murphy DL; Columbia University School of Public Health Socio-medical; Sciences Division, NY, NY 10032.
There is a scarcity of knowledge about the sexual behavior patterns of the intravenous drug abuser (IVDA), despite the potential role of this group in the heterosexual transmission of AIDS. Using a representative sample of 93 clients from the Addiction Research and Treatment Corporation (ARTC), who consented to be ano
Selwyn PA; Department of Epidemiology and Social Medicine, Montefiore; Medical Center, Bronx, NY 10467.
The debate over the provision of sterile injection equipment to intravenous drug users, as a means of preventing the spread of the AIDS epidemic, has a number of political, ethical, and clinical implications. The issue has in some respects been inappropriately dichotomized as a conflict between public health agendas a
Spina-Franca A; Livramento JA; Machado LR; Bacheschi LA; Nobrega JP; Departamento de Neurologia, Faculdade de Medicina, Universidade; de Sao Paulo.
Cerebrospinal fluid (CSF) was analysed in 50 AIDS patients in this investigation. CSF analysis included: pressure, aspect, colour, cytology (cell number, cytomorphology, and lymphocyte subpopulations), proteins concentration and their electrophoretic distribution, chloride and glycosis concentration, GOT and LDH activ
Drummond C; Edwards G; Glanz A; Glass I; Jackson P; Oppenheimer E; Sheehan M; Taylor C; Thom B; Institute of Psychiatry, Addiction Research Unit, Advisory; Council on Misuse of Drugs, United Kingdom of Great Britain.
This article presents a policy analysis of the needed responses to the problems associated with the acquired immunodeficiency syndrome and drug misuse that are now being experienced in the United Kingdom of Great Britain and Northern
Trans R Soc Trop Med Hyg. 1987;81(5):874-5. Unique Identifier : AIDSLINE MED/88219135
Schoub BD; Lyons SF; McGillivray GM; Smith AN; Johnson S; Fisher EL; Department of Virology, University of the Witwatersrand, National; Institute for Virology, Johannesburg, South Africa.
Systematic autopsy studies of 100 patients with AIDS confirmed a high incidence of adrenal lesions. Eighty eight cases were analysed, 79 men and 9 women; 57 had opportunist infection alone, 6 had Kaposi sarcomas and 30 had an association of both pathologies. The adrenal glands were normal in 19 cases and abnormal in 6
AIDS Res Hum Retroviruses. 1987;3(4):375-85. Unique Identifier : AIDSLINE MED/88192936
Saxinger C; Alter HJ; Eichberg JW; Fauci AS; Robey WG; Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, MD 20205.
Circulating HIV antigens and HIV specific antibodies in sera of experimentally infected chimpanzees were monitored by ELISA immunoassay, Western blot, and radioimmunoprecipitation procedures. Three of three chimpanzees given plasma from patients with AIDS or ARC tested positive for HIV antigens beginning six to ten we
The dual diagnosis of AIDS and substance abuse raises serious clinical and ethical issues for health care providers. Often, there are barriers to the diagnosis and referral for substance abuse treatment in people with HIV infection. Countertransference is one such barrier. Important educational needs of patients can b
Smith DE; Haight Ashbury Free Medical Clinics, San Francisco, CA 94117.
The article examines the expanding role of drug abuse treatment professionals in the AIDs epidemic, including the utilization of predictive models to help focus prevention, intervention, and treatment efforts for IV drug users, who are the second largest at-risk group for HIV contagion after homosexual males, as well
AIDS Res Hum Retroviruses. 1987;3(4):355-61. Unique Identifier : AIDSLINE MED/88192934
Goedert JJ; Eyster ME; Biggar RJ; Blattner WA; Environmental Epidemiology Branch, National Cancer Institute,; Bethesda, MD 20892.
We evaluated risk factors for human immunodeficiency virus (HIV) seropositivity in the wives/female sexual partners of hemophiliacs. One of the 6 seropositive women has developed the acquired immunodeficiency syndrome (AIDS). At least three of the others seroconverted during 1985-86, after more than four years of regu
Boll Ist Sieroter Milan. 1987;66(5):346-50. Unique Identifier : AIDSLINE MED/88209299
Cattaneo R; Franceschini F; Bettinzioli ML; Airo P; Gorla R; Stellini R; Sueri L; Cadeo GP; Carosi GP; Servizio di immunologia Clinica, Universita degli Studi di; Brescia.
We evaluated 95 HIV seropositive drug-addicts during a follow-up period of one year. The patients were classified and reclassified at each visit, according to the criteria proposed by the Centers for Disease Control (CDC) in 1986. At the first visit the patients were classified as follows: 70 in IIa-IIIa, 23 in IIb-II
Ryan B; Connor E; Minnefor A; Desposito F; Oleske J; University of Medicine and Dentistry of New Jersey, Newark.
HIV infection in pediatric patients is a multisystem chronic disease that manifests as a clinical spectrum from asymptomatic infection through symptomatic infection with opportunistic infections and malignancies. The hematopoietic system is involved early in the systemic manifestations of this disease. The hematologic
Pohl MI; Pride Institute, Eden Prairie, Minnesota.
This review indicates that cognitive dysfunction and dementia , specifically caused by chronic alcohol use, consist of subtle changes in cognition which are easily missed and/or forgotten. The nature of the dysfunction and specific neuropsychiatric and neurodiagnostic tests will be
Veatch CL 3d; California Department of Alcohol and Drug Programs, Sacramento; 95814.
State agencies have been profoundly impacted by the AIDS epidemic. In the absence of a vaccine that would prevent AIDS or of medicines that would cure it, the primary strategies of such agencies have focused on reducing the spread of AIDS by promoting cessation of high risk behaviors and thus preventing or slowing its
Abrams DI; AIDS Activities Division, San Francisco General Hospital, CA; 94110.
Human immunodeficiency virus (HIV) infection produces a spectrum of clinical syndromes, progressing in severity from asymptomatic infection through the life-threatening diseases of the acquired immunodeficiency syndrome (AIDS). Current knowledge about the epidemiology, virology, and clinical manifestations of HIV infe
MacGregor RR; Department of Medicine, University of Pennsylvania School of; Medicine, Philadelphia 19104.
Opiate use in humans is associated with a reduction in the number of circulating T-lymphocytes and in their ability to undergo transformation, probably resulting from opiate binding to T-cell antigens. (See Table 4). Patients also manifest a diffuse hyperglobulinemia, without change in circulating B-cell numbers. In v
Bull Cancer (Paris). 1988;75(2):229-32. Unique Identifier : AIDSLINE MED/88193434
Socie G; Cosset JM; Tchernia G; Le Bras P; Delfraissy JF; Girinski T; Departement des radiations et Unite INSERM 247, Institut; Gustave-Roussy, Villejuif, France.
The prognostic value of ocular manifestations and their correlation with immune changes in HIV-infected subjects (75 PGL, 23 ARC, and 17 AIDS) have been longitudinally studied with an average follow-up of one year (3 to 22 months). The most common ocular manifestations were retinal cotton-wool-like spots, observed in
Salzman SH; Smith RL; Aranda CP; Bellevue Chest Service, New York Veterans Administration Medical; Center, New York.
We reviewed 18 cases of histoplasmosis in patients at risk for the acquired immunodeficiency syndrome seen at two New York City hospitals in the past 3 1/2 years. Seventeen patients were Hispanic, including 13 born in Puerto Rico and three in South America. Clinical presentatio
Wallace JM; Hannah JB; Pulmonary Division, University of California School of Medicine,; Los Angeles.
Despite the recognition of Mycobacterium avium complex (MAC) infection as a common complication of AIDS, the specific clinical features, significance, and need for treatment have been difficult to assess. We reviewed the clinical records and autopsy material of 68 patients dying with AIDS, 32 (47 percent) of whom had
Stute R; Isenberg E; Blutspendezentrale Saarland des Staatlichen Instituts fur; Gesundheit und Umwelt, Saarbrucken.
Enzyme-immunoassays (EIA) for HIV antigen and antibodies were performed on 33,076 serum samples during an 11-month period. Prospective analysis involved samples from 21,496 blood donors, 11,086 samples sent in as coming from high-risk persons and 101 samples from AIDS patients, while retrospectively samples from 393 h
FEBS Lett. 1988 Apr 11;231(1):159-63. Unique Identifier : AIDSLINE MED/88196375
Picone D; Temussi PA; Marastoni M; Tomatis R; Motta A; Dipartimento di Chimica, Universita di Napoli, Italy.
Peptide T, an octapeptide of sequence ASTTTNYT that binds to human T cells, was studied as a zwitterion in DMSOd6 solution by means of proton NMR spectroscopy at 500 MHz. The unusual dispersion of the resonances of residues of the same type (T) makes it possible to assign all resonances to specific residues by means o
Hagberg L; Forsman A; Norkrans G; Rybo E; Svennerholm L; Department of Infectious Diseases, University of Goteborg.
Immunostimulation in the central nervous system (CNS) measured as abnormal intrathecal immunoglobulin production or activated lymphocytes in the cerebrospinal fluid (CSF), was found in 22 of 25 HIV seropositive patients. All of 11 patients with symptomatic HIV infection and nine of 14 asymptomatic patients had an incr
Int Nurs Rev. 1988 Mar-Apr;35(2):42-3. Unique Identifier : AIDSLINE MED/88197552
Styles MM; School of Nursing, University of California.
With their briefcases full of guidance from the London summit on AIDS, health ministers are ready to firm up the urgently needed policies on AIDS at home. As any new regulation on AIDS also concerns nurses, national nurses associations (NNAs) should ensure that their positions on the issues are also recognized. The f
Int Nurs Rev. 1988 Mar-Apr;35(2):53-4. Unique Identifier : AIDSLINE MED/88197554
The International Council of Nurses and the World Health Organization have jointly developed Guidelines for Nursing Management Relative to HIV Infection. As these are now being finalized and not yet approved for release, INR can only highlight the contents of this concise, authoritativ
Gasnault J; Roux FX; Vedrenne C; Department of Neurosurgery, Hopital Sainte-Anne, Paris, France.
Cerebral astrocytoma has been found in two patients with AIDS related conditions. The fortuity of this unusual association is discussed, insofar as immunosuppression could favour the growth of certain neoplasms.
Brown MM; Thompson A; Goh BT; Forster GE; Swash M; Department of Neurology, London Hospital, UK.
Unilateral infranuclear facial palsy developed in three young homosexual men. All three were positive for antibodies to human immunodeficiency virus (HIV). Two had persistent generalised lymphadenopathy, but the clinical criteria for the acquired immune deficiency syndrome (AIDS) were not fulfilled. There were no feat
J Med Educ. 1988 May;63(5):379-85. Unique Identifier : AIDSLINE MED/88200234
Fisher WA; Grenier G; Watters WW; Lamont J; Cohen M; Askwith J; Faculty of Social Science, University of Western Ontario, London,; Canada.
In the research reported here, the authors examined the relation of 82 medical students feelings about sex to their level of sexual knowledge, willingness to treat patients with sexual concerns, and participation in an elective sex education course. The results showed that the erotophobic students (those with negativ
Goldstein ML; Yuen FM; School of Social Work, State University of New York-Stony Brook.
The emerging demographics of AIDS related disease and disorders suggests a redistribution toward the population of intravenous drug users (IVDU) and the sexual partners of IVDU s. Risk reduction strategies employing education and disease prevention appear to have had significant success within the gay community as bor
Pugh P; Brenner M; Milne EN; Department of Radiological Sciences, University of California,; Irvine Medical Center, Orange 92668.
Sixty-nine percent of AIDS patients show evidence of splenomegaly on their plain chest film. This splenomegaly is not related to severity of AIDS, to intravenous drug abuse or to any specific infection or neoplasm but correlates well with severity of anemia, pancytopenia, and thrombocytopenia. Increasing splenomegaly
Pathol Res Pract. 1988 Feb;183(1):80-7. Unique Identifier : AIDSLINE MED/88203377
Horny HP; Inniger R; Kaiserling E; Busch FW; Institute of Pathology, University of Tubingen, FRG.
Diagnosis of malignant histiocytosis (MH) often resembles the solving of an intricate puzzle consisting of clinical symptoms such as lymphadenopathy, splenomegaly, fatigue, fever, and rapid progression, and hematopathological findings such as the presence of atypical histiocytes, especially in blood and bone marrow sm
Putkonen P; Albert J; Karlsson A; Persson PO; Karlen K; Hjalmarsson K; Norberg R; Department of Immunology, National Bacteriological Laboratory,; Stockholm, Sweden.
The distribution of phenotypes of the group specific component (Gc) was examined in 85 AIDS patients and in 40 couples, each consisting of one HIV seropositive patient and one seronegative sexual partner. Phenotype and allele frequencies in these groups did not differ significantly from those in a Swedish control popu
Thrombocytopenia is a relatively frequent hematological complication of HIV (human immunodeficiency virus) infection. The incidence of thrombocytopenia in a cohort of 359 homo- or bisexual men with HIV infection was 3%, while it was 9% in a cohort of 321 HIV positive persons with a history of intravenous drug abuse. W
Am J Gastroenterol. 1988 May;83(5):581-3. Unique Identifier : AIDSLINE MED/88207325
Spaedy S; Schubert TT; University of Missouri, Kansas City, School of Medicine.
Lead poisoning is uncommon in the adult population, but must be considered in the differential diagnosis of patients with abdominal pain of obscure etiology. In this paper we present a 38-yr-old male with abdominal pain, a history of alcohol abuse, and exposure to the virus responsible for acquired immunodeficiency sy
Am J Med. 1988 May;84(5):810-6. Unique Identifier : AIDSLINE MED/88207362
Rynes RI; Goldenberg DL; DiGiacomo R; Olson R; Hussain M; Veazey J; Department of Medicine, Albany Medical College, New York 12208.
A subacute, oligoarthritic syndrome developed in four patients with human immunodeficiency virus (HIV) infection. Three had true acquired immunodeficiency syndrome (AIDS) and all had lymphocyte abnormalities. The arthritis was characterized by extreme pain and disability in three patients and moderate pain in one. Kne
Mallolas J; Gatell JM; Rovira M; Conget JI; Trilla A; Soriano E; Infectious Diseases Unit, Hospital Clinic, Barcelona, Spain.
We studied two cases of disseminated tuberculosis with vertebral arch involvement in drug addicts seropositive for human immunodeficiency virus. The first patient developed a paraplegia while he was recovering from a meningeal tuberculosis. On the abdominal plain roentgenogram, the right transverse process of L-2 was
AIDS Res Hum Retroviruses. 1988 Feb;4(1):71-81. Unique Identifier : AIDSLINE MED/88209358
Mellert W; Amtmann E; Erfle V; Sauer G; Abt. fur Molekulare Zellpathologie, Gesellschaft fur Strahlen; und Umweltforschung (GSF), Neuherberg/Munchen, West Germany.
The antiviral xanthate compound tricyclodecan-9-yl-xanthogenate (code name D609) is capable of inhibiting DNA and RNA viruses in vitro. It can also inhibit the shedding of infectious HIV into the tissue culture medium from chronically infected lymphoma cells (KE37-III) as shown by infectivity assays and Western blots
AIDS Res Hum Retroviruses. 1988 Apr;4(2):149-54. Unique Identifier : AIDSLINE MED/88209364
Khanani RM; Hafeez A; Rab SM; Rasheed S; Department of Microbiology, Jinnah Postgraduate Medical Center,; Karachi, Pakistan.
We have documented evidence of the human immunodeficiency virus (HIV) infection in four individuals including a blood donor and three members of a family (husband, wife, and a child) in Karachi, Pakistan . Our data indicate that HIV has been transmitted to the wife of the seroposi
AIDS Res Hum Retroviruses. 1988 Apr;4(2):99-105. Unique Identifier : AIDSLINE MED/88209367
Harada S; Yamamoto N; Fujiki H; Institute for Virus Research, Kyoto-University, Japan.
We reported previously that TPA facilitates the replication of human immunodeficiency virus (HIV) and has a selective lethal effect on HIV-infected cells by a cytopathic effect induced by HIV. We have now studied the cytopathic effects of TPA-type tumor promoters (teleocidin, aplysiatoxin, and TPA) and the non-TPA typ
Cancer. 1988 Jun 1;61(11):2318-24. Unique Identifier : AIDSLINE MED/88210209
Gold JE; Jimenez E; Zalusky R; Department of Medicine, Beth Israel Medical Center, Mount Sinai; School of Medicine, City University of New York, New York 10003.
The most common human immunodeficiency virus-related (HIV) malignancies to date include Kaposi s sarcoma and the high-grade non-Hodgkin s lymphomas. There also appears to be an association between HIV and an aggressive form of Hodgkin s disease. In addition, there is a spectrum of HIV-related central and peripheral ne
Cancer. 1988 Jun 1;61(11):2325-37. Unique Identifier : AIDSLINE MED/88210210
Lowenthal DA; Straus DJ; Campbell SW; Gold JW; Clarkson BD; Koziner B; Department of Medicine, Memorial Sloan-Kettering Cancer Center,; New York, New York.
The clinical features and laboratory results of 63 patients with or at risk for AIDS with lymphoid neoplasias seen from November 1980 through November 1986 are reviewed. Forty-three had systemic non-Hodgkin s lymphoma (NHL), nine had primary large cell lymphomas of the brain, 11 ha
Firestein GS; Reifler D; Richman D; Gruber HE; Department of Medicine, UCSD School of Medicine, San Diego,; California 92161.
The effect of phorbol myristate acetate (PMA) on T4 (CD4) expression by monocytoid cells was studied. Greater than 99% of untreated U937 and HL-60 cells expressed surface T4 as measured with a fluorescence-activated cell sorter. The percentage of T4 positive cells decreased to less than 20% after incubation with PMA (
Lax JD; Haroutiounian G; Attia A; Rodriguez R; Thayaparan R; Bashist B; Department of Medicine, St. Luke's-Roosevelt Hospital Center, New; York, New York.
Tuberculosis of the rectum is a rare disease. A patient with a miliary pattern of pulmonary tuberculosis had a rectal lesion which proved to be tuberculosis. The patient subsequently developed several opportunistic infections characteristic of acquired immune deficiency syndrome. The clinical, endoscopic, radiologic,
Dtsch Med Wochenschr. 1988 May 13;113(19):755-62. Unique Identifier : AIDSLINE MED/88211462
Hoffken G; Lode H; Dissmann T; Ludwig WD; Hunsdiek KF; Kramer A; Hampl H; Zorr B; Mielke M; Bratzke B; et al; Medizinische Klinik und Poliklinik des Klinikum Steglitz, Freie; Universitat, Berlin.
Between 1983 and 1987, a stepwise diagnostic programme was undertaken prospectively in 37 of 100 HIV-positive patients with 40 bronchopulmonary infections. It consisted chiefly of flexible bronchoscopy combined with lavage, transbronchial biopsy and/or removal of bronchial brush cells. Taking into account all examinat
Delta coinfection or superinfection in a patient with chronic hepatitis B is characterized by a very transient delta antigenemia and an early seroconversion of IgM to IgG anti-delta. The persistent expression of delta antigen in the liver can be associated with acute, severe, or chronic hepatitis. In our two patients,
Tomita T; Chiga M; Department of Pathology and Oncology, University of Kansas; Medical Center, KS 66103.
Two young homosexual men with acquired immunodeficiency syndrome (AIDS) presented with five-lobe pneumonia and maculopapular rash, respectively, and were found to have disseminated histoplasmosis by examination of peripheral blood smears. Bone marrow smears from one patient revealed more numerous Histoplasma capsulatu
Johannessen DJ; Wilson LG; Department of Psychiatry and Behavioral Sciences, University of; Washington School of Medicine, Seattle.
Two AIDS patients with mania were found to have cryptococcal meningitis. In patients with AIDS or AIDS-related complex, physicians must thoroughly investigate the possibility of an organically based psychiatric syndrome.
Solinger AM; Adams LE; Friedman-Kien AE; Hess EV; Department of Internal Medicine, University of Cincinnati College; of Medicine, Ohio 45267.
Loss of normal immune homeostasis occurs in acquired immune deficiency syndrome (AIDS). We evaluated patients at the University of Cincinnati and New York University Medical Centers for serologic evidence of autoimmune changes. Specifically, tests for antinuclear and organ-specific antibodies by immunofluorescence, an
Jackson S; Dawson LM; Kotler DP; Department of Microbiology, University of Alabama, Birmingham; 35294.
Compared to a panel of healthy controls, sera from 13 of 23 (57%) patients with the acquired immune deficiency syndrome (AIDS) were shown to have elevated levels of circulating immune complexes (CIC) containing IgA. Levels of IgG-containing CIC were increased in seven patients (30%); no patients had elevated levels of
Kiehn TE; Cammarata R; Department of Medicine, Memorial Sloan-Kettering Cancer Center,; New York, New York 10021.
Blood cultures processed with a lysis-centrifugation (Isolator) system and a radiometric (BACTEC 13A) broth system were compared for the recovery of Mycobacterium avium-M. intracellulare from patients with acquired immunodeficiency syndrome. Forty-nine isolates of M. avium-M. intracellulare were recovered by both syst
Roberts RD; Wolkoff MJ; University of California, Los Angeles.
The inadvertent transmission of AIDS virus through contaminated whole blood has shaken the viability of the American voluntary blood supply system. For the first time since the voluntary donor system replaced the commercial blood system, there are widespread doubts about the ability of blood suppliers to meet the nati
Chak LY; Gill PS; Levine AM; Meyer PR; Anselmo JA; Petrovich Z; Department of Radiation Oncology, University of Southern; California School of Medicine, Los Angeles 90033.
Twenty-four patients with acquired immunodeficiency syndrome (AIDS) received 80 courses of radiation therapy for Kaposi s sarcoma (KS). Pain and other symptoms due to mass effects were well controlled, but KS lesions often persisted in irradiated sites. Acute radiation toxicity to doses of approximately 2,000 cGy in t
Sowell RL; Lowenstein A; Medical College of Georgia, Augusta.
Because of the potentially devastating effects AIDS has on both individuals and the health care system, nursing administrators can take a leadership role in developing comprehensive and humane strategies to combat this disease. To develop such strategies, the authors present an AIDS-related services planning model for
Miller L; Downer A; School of Medicine, University of Washington, Seattle 98115.
The AIDS knowledge and attitudes of students attending an urban high school in Seattle were pretested. Subsequently, a 50-minute AIDS lesson plan was designed using the findings. Instruction occurred one month following the pretest, with a posttest administered one week after instruction. Significant increases in know
Med Trop (Mars). 1988 Jan-Mar;48(1):19-20. Unique Identifier : AIDSLINE MED/88216064
Kadende P; Standaert B; Niragira F; Kamamfu G; Laroche R; Centre hospitalo-universitaire de Kamenge, Bujumbura (Burundi).
During a survey carried out in Bujumbura ( Burundi ) within two selected groups of H.I.V. seropositive and H.I.V. seronegative tubercular patients and their respective family, the authors noted that H.I.V. + patients reacted poorly to the specific treatment and they have continued t
Med Trop (Mars). 1988 Jan-Mar;48(1):21-5. Unique Identifier : AIDSLINE MED/88216065
Lesbordes JL; Baquillon G; Georges MC; Ngbali J; Georges AJ; Centre hospitalier des Armees H. Larrey, Toulouse, France.
Tuberculosis in Central African Republic is an endemic disease. Its prevalence is 3.87 p. 1.000. The relationship between tuberculosis and HIV infection has been observed on 39 out of 72 cases in the National Hospital of Bangui from September 1986 to June 1987. Tube
N Z Med J. 1988 May 11;101(845):241-3. Unique Identifier : AIDSLINE MED/88217108
Buisman N; Mow AC; Currie T; Devereux F; Fanning B; Hawkins T; Holden H; University of Otago Medical School, Dunedin.
A postal questionnaire was sent to 307 people, during July 1987. The questionnaire examined public knowledge, attitudes and strategies for education for future planning by the Southern Region Health Services Association. According to the age group those respondents aged 45-59 years scored best in the knowledge section
Buchanan GR; Holtkamp CA; Department of Pediatrics, University of Texas Southwestern; Medical Center at Dallas.
Mild leukopenia and thrombocytopenia are common in multitransfused hemophiliacs. Because little attention has previously been directed to measurements of erythropoiesis in these patients, we prospectively examined hemoglobin concentration and RBC indices in 94 children and young adults with hemophilia during comprehen
Kleinman S; Fitzpatrick L; Secord K; Wilke D; American Red Cross Blood Services, Los Angeles-Orange Counties; Region, CA.
We conducted anti-HIV testing on follow-up samples obtained at a mean interval of 20 weeks from 150 blood donors who had previously tested anti-HIV ELISA positive and Western blot atypical. Of 93 donors who demonstrated reactivity to HIV core protein p24, 4 progressed to positive Western blots. Most of the remaining d
Kruskall MS; Popovsky MA; Pacini DG; Donovan LM; Ransil BJ; Department of Pathology and Medicine, Beth Israel Hospital,; Boston, MA.
Autologous blood donations may provide a new source of blood when components not used by the donors are deemed suitable for homologous use. However, the risk of transfusion-transmitted diseases form such donors has not been evaluated. We compared the prevalence of infectious markers and rate of abnormal responses to a
Gurgo C; Guo HG; Franchini G; Aldovini A; Collalti E; Farrell K; Wong-Staal F; Gallo RC; Reitz MS Jr; Center for Endocrinology and Experimental Oncology of the CNR,; Naples, Italy.
One of the striking molecular aspects of the human T-cell lymphotropic virus type III (HTLV-III) (now called HIV-1) is an unusually large variability in the env genes of different isolates. These differences are clustered primarily within the coding sequences for the large envelope protein and are interspersed among r
Tochikura TS; Nakashima H; Tanabe A; Yamamoto N; Department of Virology and Parasitology, Yamaguchi University; School of Medicine, Japan.
A coculture system using Molt-4 and its HIV-producing cell, Molt-4/HIV(HTLV-IIIB) induced syncytia very efficiently. Among the cocultivations with various ratios of two types of cells, multinucleated giant cells were most clearly visible 20 hr after culture in a cell ratio of 5:5. The degree of cell fusion apparently
Tochikura TS; Nakashima H; Uemura Y; Goto T; Suyama T; Kobayashi N; Yamamoto N; Department of Virology and Parasitology, Yamaguchi University; School of Medicine, Japan.
Immunoglobulin samples (HIV-Ig) were prepared by cold ethanol fractionation of human plasma containing antibody against human immunodeficiency virus (HIV). The ability to prevent viral spreading was studied using either human T-cell leukemia virus type I (HTLV-I)-carrying MT-4 cells or in a coculture system using MOLT
Nosik DN; Korneeva MN; Korsun NS; Maiorova SN; Parshina OV
Trials of clinically advantageous national inducers, thymus hormones, as well as human recombinant alpha 2-interferon were carried out in cultures of continuous lymphoblastoid cells H9/IIIB infected with HIV virus. The virus-inhibiting effect for HIV was observed with interferon in doses of 10-100 IU/ml. At a concentr
Am J Epidemiol. 1988 Jun;127(6):1250-60. Unique Identifier : AIDSLINE MED/88220305
De Cock KM; Niland JC; Lu HP; Rahimian A; Edwards V; Shriver K; Govindarajan S; Redeker AG; Liver Unit, University of Southern California, Los Angeles.
Stored serum specimens from 723 patients with acute hepatitis B and 228 patients with chronic hepatitis B seen between 1977 and 1985 in the Hepatitis Clinic of the Los Angeles County-University of Southern California Medical Center, Los Angeles, CA, were tested for antibody to human immunodeficiency virus (anti-HIV).
Am J Epidemiol. 1988 Jun;127(6):1312-4. Unique Identifier : AIDSLINE MED/88220312
Farci P; Novick DM; Lai ME; Orgiana G; Strazzera A; Beatrice ST; Des Jarlais DC; Balestrieri A; Department of Internal Medicine, University of Cagliari, Via San; Giorgio, Italy.
Am J Hematol. 1988 May;28(1):27-32. Unique Identifier : AIDSLINE MED/88220319
Smiley ML; White GC 2d; Becherer P; Macik G; Matthews TJ; Weinhold KJ; McMillan C; Bolognesi D; Division of Infectious Diseases, University of North Carolina,; Chapel Hill 27514.
To examine the variables associated with heterosexual transmission of human immunodeficiency virus (HIV), we studied 32 couples in our hemophilia center who had steady sexual relationships for periods more than 1 year. Of the 32 sexual partners of the hemophiliacs, five (15.6%) were HIV seropositive. All five hemophil
Koop CE; U.S. Department of Health and Human Services, Washington, DC; 20201.
Ethical challenges posed by acquired immunodeficiency syndrome (AIDS) are described. A small minority of health-care workers are refusing to treat persons with AIDS because they fear exposure, and some hospitals known to care for AIDS patients are being avoided as sites for training in the health professions. Some pat
Woolsey RM; Chambers TJ; Chung HD; McGarry JD; Department of Neurology, St Louis University, MO.
A homosexual man, seropositive for human immunodeficiency virus, developed back and leg pain that evolved, over three weeks, into a T-10 anesthetic, areflexic paraplegia. Spinal fluid examination showed lymphocytosis, markedly elevated spinal fluid protein, and hypoglycorrhachia. A spinal cord biopsy specimen disclose
In a sample of 97 HIV-1 seropositive persons which comprised 34 patients with AIDS, 30 patients with persistent generalized lymphadenopathy or with AIDS related complex and 33 persons who were without symptoms and called healthy, three genetic marker systems were examined: 1) GC, the group-specific component of serum
Bolski E; Hunt RJ; School of Dentistry, University of North Carolina.
Oral and perioral lesions have been widely reported in homosexual males and intravenous drug abusers who are seropositive for the human immunodeficiency virus (HIV) or have acquired immunodeficiency syndrome (AIDS). Several case reports have also noted some AIDS-associated lesions among persons with hemophilia, but th
Am J Med. 1988 May;84(5):801-9. Unique Identifier : AIDSLINE MED/88207361
Daul CB; deShazo RD; Andes WA; Tulane/Louisiana State Universities, AIDS Treatment Evaluation; Unit, New Orleans.
Thirty-seven heterosexual hemophiliac patients underwent prospective evaluation with clinical examinations, serologic studies for antibody to human immunodeficiency virus (HIV), and tests of immune function for an average of 37 months. At the time of entry into the study in 1982 to 1983, 18 subjects (49 percent) were
AIDS Res Hum Retroviruses. 1988 Feb;4(1):3-9. Unique Identifier : AIDSLINE MED/88209353
Khalife J; Guy B; Capron M; Kieny MP; Ameisen JC; Montagnier L; Lecocq JP; Capron A; Centre d'Immunologie et de Biologie Parasitaire, Institut; Pasteur, Lille, France.
HIV-infected individuals progress toward AIDS despite the early elicitation of a specific immune response. Analysis of the isotypic distribution of HIV-specific antibodies appears of special interest for two reasons: first, isotypic diversity is partly under the control of antigen-specific T-helper cells, the very cel
AIDS Res Hum Retroviruses. 1988 Feb;4(1):63-9. Unique Identifier : AIDSLINE MED/88209357
Langlois AJ; Matthews TJ; Weinhold KJ; Chaffee S; Hershfield M; Bolognesi DP; Duke University Medical Center, Department of Surgery, Durham, NC; 27710.
A rapid, simple, reproducible and semi-quantitative assay to measure neutralizing antibodies has been developed. It employs a unique cell line which is exquisitively sensitive to infection with all HIV isolates tested. The assay is amenable to microtiter formulation as well as analysis by automation.
Smillie JM; Ala FA; Virology Department, West Midlands Regional Transfusion Centre,; Birmingham, U.K.
In an attempt to reduce the cost of testing for anti-human immunodeficiency virus (HIV) we looked at the possibility of recycling the Wellcozyme (R) HIV antigen bound wells; our findings showed that there was no significant reduction in sensitivity of the test samples or controls when run in parallel with new plates.
J Med Virol. 1988 Apr;24(4):413-22. Unique Identifier : AIDSLINE MED/88214369
Casoli C; Magnani G; Scovassi I; Bertazzoni U; Starcich R; Istituto di Patologia Medica, Universita di Parma, Italy.
The association between human immunodeficiency virus type I (HIV-I) infection and high levels of erythrocyte adenosine deaminase (ADA) has been suggested by Cowan et al [1986]. We have analyzed the specific activities of the same enzyme during different stages of acquired immunodeficiency syndrome (AIDS), including as
Biniek R; Bartholome M; Schulz M; Lehmann HJ; Gesemann H; Scheiermann N; Brockmeyer NH; Derks M; Balzer K; Department of Neurology, University Hospital Essen, Federal; Republic of Germany.
Thirty-one serum and CSF samples from 21 HIV-antibody-positive patients with neurological deficits were examined to prove or exclude intrathecal production of HIV antibodies. By dilution, sera were adjusted to the IgG concentration of the corresponding CSF samples. Both samples were then serially diluted in log2 steps
JAMA. 1988 May 27;259(20):3023-6. Unique Identifier : AIDSLINE MED/88215129
Henry K; Chinnock BJ; Quinn RP; Fletcher CV; de Miranda P; Balfour HH Jr; Department of Medicine, St. Paul-Ramsey Medical Center, MN.
Zidovudine was present in the semen and serum of six patients with acquired immunodeficiency syndrome or the related complex who were receiving 200 mg of the drug orally every four to six hours. Mean semen zidovudine levels (as measured by a new radioimmunoassay) in samples collected 0.75 to 1.25 hours after oral dosi
Med J Aust. 1988 May 16;148(10):503-5. Unique Identifier : AIDSLINE MED/88216340
Brake FA; Maskill WJ; Howard TS; Breschkin AM; Gandhi SS; National Biological Standards Laboratory, Commonwealth Department; of Community Services and Health, Parkville, Vic.
We tested 54 reagents of human origin that were included in a number of diagnostic kits to be used as positive or negative control material, and for quality assurance, for the presence of antibodies to human immunodeficiency virus-1 (HIV-1). Of these, 12 (22%) reagents were found to give positive results for antibodie
Smith RL; Ripps CS; Lewis ML; Department of Medicine, New York Veterans Administration Medical; Center, New York 10010.
We investigated the source of elevated serum lactate dehydrogenase (LDH) levels in seven patients with Pneumocystis carinii pneumonia (PCP) by analyzing blood and bronchoalveolar lavage (BAL) albumin (ALB) and LDH, with isoenzyme fractionation. Four patients with non-PCP lung disease served as control subjects. In PCP
von Eiff M; Fegeler W; van de Loo J; Medizinische Klinik und Poliklinik, Abteilung Innere Medizin A,; Universitat Munster.
Bronchoscopy with bronchoalveolar lavage was undertaken in 21 immunocompromised patients for microbiological and cytological diagnosis. In all of these patients radiologically confirmed pneumonic lesions had developed which, under empirical antibiotic treatment, had progressed or not clearly regressed. In four patient
Janier M; Flageul B; Drouet L; Scrobohaci ML; Villette JM; Palangie A; Cottenot F; Clinique des Maladies Cutanees et Syphilitiques, Hopital; Saint-Louis, France.
Patients infected by the human immunodeficiency virus (HIV) represent a model in which endothelial proliferation and/or damage are of concern. We studied Von Willebrand factor (VWF) plasma values as a presumed marker of endothelial proliferation in patients with the lymphadenopathy syndrome (LAS) (n = 45), AIDS-relate
Donnelly H; Bernard EM; Rothkotter H; Gold JW; Armstrong D; Department of Medicine, Memorial Sloan-Kettering Cancer Center,; New York, New York 10021.
We used a bioassay to measure pentamidine concentrations in autopsy specimens from 22 patients with AIDS. Patients received pentamidine isethionate (approximately 4 mg/kg per day) parenterally for Pneumocystis carinii pneumonia; one received monthly prophylaxis. We found that lung levels of 30 micrograms/g were achiev
A transregulatory gene, trs, of human immunodeficiency virus I (HIV-1) was expressed in bacteria as a 26-kD fusion protein. Survey of over 100 individuals infected with HIV revealed a nonrandom distribution of seropositivity against trs: a few of the asymptomatic carriers and AIDS patients (less than 5%) had sera that
AIDS Res Hum Retroviruses. 1988 Feb;4(1):51-62. Unique Identifier : AIDSLINE MED/88209356
Zweig M; Showalter SD; Bladen SV; Gilden RV; Arthur LO; Robey WG; Nara PL; Fischinger PJ; Program Resources, Inc., NCI-Frederick Cancer Research Facility,; MD.
We partially purified the human immunodeficiency virus (HIV) glycoprotein gp41 from infected H9 cells by immunoaffinity chromatography using a column containing the M25 monoclonal antibody (diMarzo-Veronese et al., 1985). A pH 11.5 buffer worked best for eluting the glycoprotein from this column. The eluted gp41 was u
AIDS Res Hum Retroviruses. 1988 Apr;4(2):121-9. Unique Identifier : AIDSLINE MED/88209361
Vuillier F; Bianco NE; Montagnier L; Dighiero G; Departement de Medecine, Institut Pasteur, Paris, France.
Two color cytofluorometric analyses of CD3-, CD16+, Leu 19+ natural killer cells (NK) were assessed in HIV seropositive patients, high-risk seronegative homosexuals, and healthy heterosexuals. A selective depletion of lymphocytes bearing NK phenotypes was found among HIV-positive infected patients. When the CD16+ lymp
AIDS Res Hum Retroviruses. 1988 Apr;4(2):137-48. Unique Identifier : AIDSLINE MED/88209363
Marlink RG; Ricard D; M'Boup S; Kanki PJ; Romet-Lemonne JL; N'Doye I; Diop K; Simpson MA; Greco F; Chou MJ; et al; Department of Cancer Biology, Harvard School of Public Health,; Boston, MA.
We studied the clinical status and certain hematologic and immunologic parameters in healthy prostitutes from Dakar, Senegal who were seropositive for antibodies to human immunodeficiency virus type-2 (HIV-2). Generalized lymphadenopathy and clinical signs or symptoms similar to t
AIDS Res Hum Retroviruses. 1988 Apr;4(2):83-90. Unique Identifier : AIDSLINE MED/88209365
Brasseur R; Cornet B; Burny A; Vandenbranden M; Ruysschaert JM; Laboratory of Macromolecules at Interfaces, Brussels, Belgium.
The complete amino-acid sequence of the gp160 polyprotein of HIV (strain WMJ1) has been analyzed by the Eisenberg procedure. The region surrounding the cleavage site between the gp120 and the gp41 subunit contains a receptor-like region immediately followed by a transmembrane-like region containing approximately 13 re
EMBO J. 1988 Feb;7(2):513-8. Unique Identifier : AIDSLINE MED/88211564
McClure MO; Marsh M; Weiss RA; Chester Beatty Laboratories, Institute of Cancer Research,; London, UK.
The effect of weak bases (NH4Cl and amantadine) and carboxylic ionophores (monensin) on the infection of CD4 (T4) positive human cell lines by HIV-1 is examined. These reagents, which raise the pH of acidic intracellular organelles, fail to inhibit HIV-1 entry and the events leading to viral protein synthesis at conce
Tribe DE; Reed DL; Lindell P; Kenealy WR; Ferguson BQ; Cybulski R; Winslow D; Waselefsky DM; Petteway SR Jr; Medical Products Department, E. I. du Pont de Nemours and; Company, Wilmington, Delaware 19898.
Normal blood donors were examined for human immunodeficiency virus (HIV)-reactive antibodies with both virus- and Escherichia coli-expressed env- and gag-coded antigens. The frequency of samples from normal (low-risk) donors that were repeatedly reactive with an HIV enzyme-linked immunosorbent assay blood screening te
Nature. 1988 May 19;333(6170):278-80. Unique Identifier : AIDSLINE MED/88216822
Fields AP; Bednarik DP; Hess A; May WS; Johns Hopkins Oncology Center, Baltimore, Maryland 21231.
AIDS is an immunoregulatory disorder characterized by depletion of the CD4+, helper/inducer lymphocyte population. The causative agent of this disease is the human immunodeficiency virus, HIV, which infects CD4+ cells and leads to cytopathic effects characterized by syncytia formation and cell death. Recent studies ha
Proc Natl Acad Sci U S A. 1988 May;85(10):3570-4. Unique Identifier : AIDSLINE MED/88217943
Leonard R; Zagury D; Desportes I; Bernard J; Zagury JF; Gallo RC; Universite P. and M. Curie, Paris, France.
A principal feature of acquired immunodeficiency syndrome is depletion of T4 lymphocytes, which is partly due to a direct cytopathic effect of the virus. Both syncytial formation (viral-induced cell fusion) and premature cell death have been cited as the major cause for this phenomenon. By kinetic analysis of cell pro
Mozzi F; Zanella A; Bellobuono A; Vianello L; Melotti S; Mascaretti L; Poli F; Lecchi L; Sirchia G; Centro Trasfusionale e di Immunologia dei Trapianti, Ospedale; Maggiore Policlinico, Milano, Italia.
Respiratory disorders are present in at least 40% of patients with the acquired immunodeficiency syndrome (AIDS) and are the commonest mode of presentation. Lung pathology ranges from infections, both opportunistic and non-opportunistic, to Kaposi s sarcoma and lymphoid interstitial pneumonia. AIDS-related lung proble
Can Med Assoc J. 1988 May 1;138(9):797-807. Unique Identifier : AIDSLINE MED/88194202
Wainberg MA; Kendall O; Gilmore N; Lady Davis Institute for Medical Research, Montreal.
Human immunodeficiency virus type 1 (HIV-1) has been clearly associated with a variety of new illnesses, including profound immunodeficiency (acquired immune deficiency syndrome [AIDS]), wasting syndromes (formerly termed AIDS-related complex [ARC]) and neurologic syndromes, including neuropathy, myelopathy and enceph
Derfler K; Schaller A; Herold C; Balcke P; Nowotny C; Walter R; Kopsa H; Endler M; Stockenhuber F; Kletter K; I. Medical Department, University of Vienna, Austria.
The successful outcome of a pregnancy complicated by reversible renal failure secondary to total ureteral obstruction caused by a pregnant uterus and treated temporarily with nephrostomy is reported. The cyclosporine A (CsA) and prednisone treated female recipient of a cadaveric renal allograft gave birth to a male ch
Barbiano di Belgiojoso G; Genderini A; Zanchetta N; Lazzarin A; Bertoli S; Servizio di Nefrologia e Dialisi, Universita di Milano, Ospedale; L. Sacco, Italy.
Friedland GH; Klein RS; Department of Medicine, Montefiore Medical Center, Albert; Einstein College of Medicine, Bronx, N.Y.
Despite the inexorable spread of HIV infection and disease worldwide, only three routes of transmission (inoculation of blood, sexual and perinatal) still remain important. This article reviews current information related to the routes of transmission of HIV infection.
Zenilman J; Division of Sexually Transmitted Diseases, Centers for Disease; Control, Atlanta, GA 30333.
In 1986, an estimated 13 million cases of sexually transmitted diseases (STDs) were diagnosed in the United States , with the highest incidence rates occurring within the adolescent age group. Homosexual adolescent men are at particularly high risk for STDs. Because of the myriad clinic
Remafedi GJ; Department of Pediatrics, University of Minnesota Hospital and; Clinic, Minneapolis.
In order to be effective, the national effort to contain the spread of Acquired Immunodeficiency Syndrome (AIDS) must include a youth focus. Knowledge of adolescent sexual behavior, drug use, and sexually transmitted diseases suggests that many adolescents are in jeopardy of acquiring Human Immunodeficiency Virus (HIV
Shaffer HJ; Costikyan NS; Department of Psychiatry, Harvard Medical School, Cambridge; Hospital, MA 02139.
This article examines some of the differential diagnostic considerations associated with the interaction between advanced cocaine psychosis and the neuropsychiatric manifestations of AIDS-Spectrum Disorders. A clinical case is presented to illustrate the potential for institutional countertransference in the treatment
Ognibene FP; Pass HI; Roth JA; Shelhamer JH; Milne EN; Critical Care Medicine Department, National Institutes of Health,; Bethesda, Maryland.
A pure pattern-recognition approach to lung diseases in immune compromised patients as seen on the chest film is of limited value since any infection can present with several different patterns, and processes such as embolism, aspiration, edema, and hemorrhage may give appearances similar to infection. However certain
Rubin SA; Department of Radiology, University of Texas Medical Branch,; Galveston 77550.
In the last two decades research in immunology has greatly expanded our knowledge of this important medical specialty. Many diseases of previously unknown etiology are now much better understood. This review emphasizes the basics of immunology in order to assist the reader in understanding the mechanisms that cause im
Klin Wochenschr. 1988 Mar 1;66(5):212-5. Unique Identifier : AIDSLINE MED/88201002
Duzgun F; Dickgiesser N; Schuster D; Lengfelder E; Teuber J; Institut fur Medizinische Mikrobiologie und Hygiene, Klinikum; der Stadt Mannheim, Mannheim.
51 human sera containing antibodies to human immunodeficiency virus 1 (= HIV-1) were examined for HIV-1-antigen by three different enzyme immunoassay procedures (= EIA) of Abbott, Organon and Dupont. Sensibilities, handling as well as the correlation with the clinical stages of HIV-infection were compared. The EIA s d
Med Decis Making. 1988 Apr-Jun;8(2):132-44. Unique Identifier : AIDSLINE MED/88201565
Roach PJ; Fleming C; Hagen MD; Pauker SG; Department of Medicine, New England Medical Center, Tufts; University School of Medicine, Boston, Massachusetts.
Ficarra G; Barone R; Gaglioti D; Milo D; Riccardi R; Romagnoli P; Zorn M; Division of Maxillofacial Surgery, University of Florence, Italy.
During a prospective investigation of oral lesions of 120 consecutive patients positive for human immunodeficiency virus, belonging to the intravenous drug abuser risk group and other risk categories, we observed hairy leukoplakia (HL) in 23 cases (19%). The median age of the patients was 27 years (range, 20 to 50 yea
Am Fam Physician. 1988 May;37(5):175-83. Unique Identifier : AIDSLINE MED/88207123
Johnson CA; University of Kansas School of Medicine, Kansas City.
Routine obstetric screening for all patients should include a Pap smear, urinalysis and urine culture, complete blood count, blood type, Rh factor and direct Coombs test. Patients should also be screened for syphilis, rubella, gonorrhea and diabetes. For patients at high risk for certain conditions, additional studie
AIDS Res Hum Retroviruses. 1988 Apr;4(2):131-6. Unique Identifier : AIDSLINE MED/88209362
Varnier OE; Lillo FB; Reina S; De Maria A; Terragna A; Schito G; Institute of Microbiology, School of Medicine, Genova, Italy.
The suitability of collecting whole blood specimens on filter paper disks for HIV antibody assay was evaluated. ELISA and Western blot assay results were in complete agreement for serum and blood spot disk samples. Sensitivity of the two methods was tested using diluted whole blood and sera from HIV-seropositive indiv
AIDS Res Hum Retroviruses. 1988 Apr;4(2):91-8. Unique Identifier : AIDSLINE MED/88209366
Yoshiyama H; Nakashima H; Kobayashi S; Yamamoto N; Department of Virology and Parasitology, Yamaguchi University; School of Medicine, Japan.
A rabbit antiserum against LAV was prepared. This serum reacted with both LAV and HTLV-III identically in the immunodiffusion and immunoprecipitation. It was also confirmed that the rabbit serum in the immunofluorescence (IF) studies contained several isolates of human immunodeficiency virus (HIV) including LAV, HTLV-
Lash RH; Tubbs RR; Calabrese LH; Department of Pathology, Cleveland Clinic Foundation, OH 44106.
Homosexual patients with persistent generalized lymphadenopathy usually show an abnormal expansion of paracortical T8+ lymphocytes relative to T4+ cells in lymph nodes with reactive follicular hyperplasia (RFH). This study was designed to characterize further the paracortical lymphocyte population in homosexual men wi
Gill ON; Public Health Laboratory Service Communicable Disease; Surveillance Centre, London, U.K.
Interest and concern that the shared communion cup may act as a vehicle for indirectly transmitting infectious disease was reawakened when the human immunodeficiency virus (HIV) was detected in the saliva of infected persons. Bacteriological experiments have shown that the occasional transmission of micro-organisms is
Benveniste RE; Morton WR; Clark EA; Tsai CC; Ochs HD; Ward JM; Kuller L; Knott WB; Hill RW; Gale MJ; et al; Laboratory of Viral Carcinogenesis, National Cancer Institute,; Frederick, Maryland 21701-1013.
A primate lymphotropic lentivirus was isolated on the human T-cell line HuT 78 after cocultivation of a lymph node from a pig-tailed macaque (Macaca nemestrina) that had died with malignant lymphoma. This isolate, originally designated M. nemestrina immunodeficiency virus (MnIV) and now classified as simian immunodefi
Lackner AA; Rodriguez MH; Bush CE; Munn RJ; Kwang HS; Moore PF; Osborn KG; Marx PA; Gardner MB; Lowenstine LJ; California Primate Research Center, University of California,; Davis 95616.
Simian acquired immune deficiency syndrome (SAIDS) in rhesus macaques (Macaca mulatta) at the California Primate Research Center is caused by a type D retrovirus designated SAIDS retrovirus serotype 1 (SRV-1). This syndrome is characterized by profound immunosuppression and death associated with opportunistic infectio
Med Hypotheses. 1988 Mar;25(3):151-62. Unique Identifier : AIDSLINE MED/88216316
Papadopulos-Eleopulos E; Royal Perth Hospital, Medical Physics Dept., Western Australia.
The emergence of AIDS as a recognizable disease, its epidemiology, the clinical and laboratory data and the way in which they have been interpreted to deduce the currently acceptable hypothesis of its aetiology and mechanism of transmission are critically examined. There is no compelling reason for preferring the vira
A technological scheme has been developed for purification of recombinant antigen of surface protein (ASP) of the causative virus of AIDS from Escherichia coli cells carrying plasmid pL2 which codes for the synthesis of a hybrid polypeptide consisting of phage lambda N protein (59 amino acid residues) and a fragment o
Hamper UM; Goldblum LE; Hutchins GM; Sheth S; Dahnert WF; Bartlett JG; Sanders RC; Department of Radiology and Radiological Science, Johns Hopkins; Medical Institutions, Baltimore, MD 21205.
Renal sonography was performed in 36 patients with clinical and/or laboratory evidence of AIDS, usually because of deteriorating renal function. In 15 patients, histopathologic specimens were reviewed to characterize renal pathologic changes underlying the sonographic findings. Sonographic evaluation included determin
Jackson JB; Sannerud K; Rhame FS; Balfour HH Jr; Department of Laboratory Medicine and Pathology, University of; Minnesota School of Medicine, Minneapolis.
Two commercial enzyme-linked immunosorbent assays (EIAs) for human immunodeficiency virus (HIV) antigens were evaluated for sensitivity and reproducibility by use of supernatant fluid from cell cultures of peripheral mononuclear cells of 18 patients with acquired immunodeficiency syndrome (AIDS) and 12 asymptomatic HI
Arnow PM; Fellner S; Harrington R; Leuther M; Department of Medicine, University of Chicago, IL.
Eighty-three chronic hemodialysis patients were tested for human immunodeficiency virus (HIV) infection. Testing included screening enzyme immunoassay (EIA) for HIV antibodies, competitive EIA for envelope and core antibodies, EIA for HIV antigen, and lymphocyte culture. Five (6%) of the patients had positive screenin
Carbone LG; Cohen DJ; Hardy MA; Benvenisty AI; Scully BE; Appel GB; Department of Medicine, Columbia University, College of; Physicians and Surgeons, New York.
Diagnosing the acquired immunodeficiency syndrome (AIDS) in transplant recipients can be difficult due to the patient s medication-induced immunosuppressed state. We report two renal allograft recipients who acquired HIV infection at the time of transplantation and later went on to develop multiple opportunistic infec
Ann Intern Med. 1988 Jun;108(6):785-90. Unique Identifier : AIDSLINE MED/88220867
Farzadegan H; Polis MA; Wolinsky SM; Rinaldo CR Jr; Sninsky JJ; Kwok S; Griffith RL; Kaslow RA; Phair JP; Polk BF; et al; Johns Hopkins University School of Hygiene and Public Health,; Baltimore, Maryland.
Four asymptomatic homosexual men reverted from positive to negative serologic results for the human immunodeficiency virus, type 1 (HIV-1) over 2.5 years, as shown by enzyme-linked immunosorbent assay (ELISA) and Western blot. Antibody bands in the Western blot from three men were undetectable 6 to 12 months after bei
Annu Rev Med. 1988;39:63-73. Unique Identifier : AIDSLINE MED/88221109
Penn I; Department of Surgery, University of Cincinnati Medical Center,; Ohio 45267.
Immunocompromised patients are prone to develop certain malignancies, particularly involving cells of the immune system itself (1-3). In this chapter we describe the various neoplasms, note the differences between these and similar cancers in the general population, emphasize similar tumor patterns in different types
Gaines H; von Sydow M; Parry JV; Forsgren M; Pehrson PO; Sonnerborg A; Mortimer PP; Strannegard O; Department of Infectious Diseases, Roslagstull Hospital,; Karolinska Institute, Stockholm, Sweden.
Consecutive serum samples obtained from 20 homosexual men during symptomatic primary HIV infection were examined by a variety of IgG and IgM antibody assays. All sera obtained 2-5 weeks after onset of disease contained IgM anti-HIV as demonstrated by an IgM antibody capture assay. The IgM antibodies appeared during th
Lange JM; Parry JV; de Wolf F; Mortimer PP; Goudsmit J; Department of Virology, University of Amsterdam, The Netherlands.
Sequential serum samples from 55 homosexual men with primary HIV infection were tested for IgM anti-HIV. An early IgM response was found in 27 out of 55 (49%). In five cases IgM anti-HIV was detected 1-3 1/4 months prior to IgG anti-HIV seroconversion, as detected by a commercially available ELISA, but in no case was
de Gans J; Lange JM; Derix MM; de Wolf F; Eeftinck Schattenkerk JK; Danner SA; Ongerboer de Visser BW; Cload P; Goudsmit J; Department of Neurology, University of Amsterdam, The; Netherlands.
Six HIV-antigenaemic patients with AIDS or AIDS-related complex were studied to assess the effect of treatment with low-dose zidovudine (250 mg) in 6-hourly doses on HIV antigen (HIV-Ag) levels in cerebrospinal fluid (CSF). HIV-Ag was detected in CSF of three patients before treatment. These patients became CSF HIV-Ag
Tsiquaye KN; Youle M; Chanas AC; Department of Medical Microbiology, London School of Hygiene and; Tropical Medicine, UK.
Addition of varying concentrations of HIV-1-seropositive plasma to purified virus particles and soluble viral antigen preparation inhibited the detection of HIV-1-antigen by ELISA. The degree of inhibition on p24 antigen ELISA depended on the relative concentrations of viral antigen and anti-p24 antibodies in the mixt
Greenblatt RM; Lukehart SA; Plummer FA; Quinn TC; Critchlow CW; Ashley RL; D'Costa LJ; Ndinya-Achola JO; Corey L; Ronald AR; et al; Department of Medicine, University of Washington, Seattle.
Among 115 heterosexual men who presented with genital ulcers to a sexually transmitted disease clinic in Nairobi, Kenya , the prevalence of serum antibody to HIV was 16.5%. A past history of genital ulcers was reported by 12 (63%) of 19 men with antibody to HIV versus 30 (31%) of 96
Berglund O; Beckman S; Grillner L; Jansson B; Lidbrink P; Karlsson A; Morfeldt-Mansson L; Pehrson PO; Torngren M; Wiechel B; et al; Department of Environment, Health, and Infectious Diseases; Controls, Karolinska Hospital, Stockholm, Sweden.
Thirty-five out of approximately 800 known HIV-seropositive people in Stockholm by mid-1986 were blood donors during the period 1979-1986. Almost all, i.e. 349 recipients of their blood components (red blood cells, platelets, plasma) could be traced. One hundred and eighty were still alive and 112 of these on further
van den Hoek JA; Coutinho RA; van Haastrecht HJ; van Zadelhoff AW; Goudsmit J; Municipal Health Service, Department of Infectious Diseases,; Amsterdam, The Netherlands.
In December 1985 we started a study to determine the prevalence and risk factors of HIV infection among drug users and drug-using prostitutes in Amsterdam. Recruitment took place at methadone posts (not drug-free; i.e. a low-threshold programme on which some drug users continue to use hard drugs, but at a lower level)
Ng VL; Hwang KM; Reyes GR; Kaplan LD; Khayam-Bashi H; Hadley WK; McGrath MS; Department of Laboratory Medicine, UCSF.
We observed a human immunodeficiency virus (HIV)-infected homosexual male with AIDS related complex (ARC) who had a serum globulin level of 80 g/L. Serum protein electrophoresis revealed a gamma globulin fraction of 40 g/L, of which 50% (20 g/L) was contained within a paraprotein spike, comprised predominantly of IgG
Murray HW; Scavuzzo DA; Chaparas SD; Roberts RB; Division of Infectious Diseases, Cornell University Medical; College, New York.
Patients with acquired immunodeficiency syndrome (AIDS) who have Mycobacterium avium-Mycobacterium intracellulare (MAI) infection typically have widely disseminated disease, often fail to respond to multi-drug chemotherapeutic regimens, and show little or no inflammatory tissue response. To determine if this clinicopa
Int Nurs Rev. 1988 Mar-Apr;35(2):35-40. Unique Identifier : AIDSLINE MED/88197550
Kay K
AIDS (acquired immunodeficiency syndrome) knows no national boundaries. It has been reported from every part of the world. And the number of victims is growing. Today some 150,000 people are believed to be suffering from the disease. By 1991 one million new cases of AIDS could develop in people already infected with h
N Engl J Med. 1988 May 19;318(20):1295-300. Unique Identifier : AIDSLINE MED/88202068
de Preval C; Hadam MR; Mach B; Department of Microbiology, University of Geneva Medical School,; Switzerland.
HLA Class II-negative severe combined immunodeficiency (SCID) results from a congenital defect characterized by an absence of HLA Class II antigens. Patients with the disorder have no HLA-DR, DQ, or DP antigens or mRNAs in their peripheral-blood lymphocytes. The affected gene is a recessive, transacting regulatory gen
Nature. 1988 May 5;333(6168):78-81. Unique Identifier : AIDSLINE MED/88202107
Valerie K; Delers A; Bruck C; Thiriart C; Rosenberg H; Debouck C; Rosenberg M; Department of Molecular Genetics, Smith Kline and French; Laboratories, King of Prussia, Pennsylvania 19406-0939.
Recent studies indicate that human immunodeficiency virus type 1 (HIV) gene expression can be dramatically enhanced by certain heterologous viral and chemical agents, implicating these as potential reactivating agents of latent virus infection. A common denominator shared by these agents is their ability to cause stre
Sewankambo NK; Carswell JW; Mugerwa RD; Lloyd G; Kataaha P; Downing RG; Lucas S; Department of Medicine, Mulago Hospital, Kampala, Uganda.
One hundred and fourteen household contacts of 23 patients with AIDS or suspected AIDS were examined for evidence of infection with HIV. In total 12 contacts had antibodies to the virus by a competitive enzyme-linked immunosorbent assay (ELISA), confirmed by Western blot. Ten of these seropositive contacts were the se
Colebunders R; Mann JM; Francis H; Bila K; Izaley L; Kakonde N; Hood AF; Quinn TC; Gigase P; Van Marck E; et al; Project SIDA, Ministry of Public Health, Kinshasa, Zaire.
Of 284 patients hospitalized with HIV infection, 52 (18%) presented with a generalized pruritic papular eruption. No significant association between this eruption and other HIV manifestations or any opportunistic infection was found. Fifty-three of 61 (87%) consecutive African patients referred for a generalized papul
Lacey JN; Forbes MA; Waugh MA; Cooper EH; Hambling MH; Department of Genito-urinary Medicine, General Infirmary at; Leeds, UK.
Serum beta 2-microglobulin (beta 2-M) was measured in two prospectively evaluated groups of homosexual men in 1983 and 1985. Serum beta 2-M was raised in 64% of patients with HIV infection, but in only 6.7% of uninfected homosexuals. Depression of the total lymphocyte count was only clinically useful when it reached l
Des Jarlais DC; Friedman SR; New York State Division of Substance Abuse Services, NY 10027.
Research on the epidemiology of HIV infection among IV drug users is still at a relatively early stage. Multilocation studies that would permit better geographic comparisons are greatly needed. Multi-method studies within single geographic areas are also needed to assess possible biases with respect to sample recruitm
Tenner-Racz K; Racz P; Dietrich M; Kern P; Janossy G; Veronese-Dimarzo F; Klatzmann D; Gluckman JC; Popovic M; Department of Haematology, Allgemeines Krankenhaus St. Georg,; Hamburg, West Germany.
Recently there has been much interest in using immunohistology with monoclonal antibodies (MABs) against different cells of the immune system in lymph nodes (LNs) of patients with HIV infection. The panel of these MABs is becoming increasingly extensive. In this study we report on our finding that by using a limited n
Mycobacterial infections were confirmed in 629 HIV-infected persons (1.4%). Five patients had a generalized infection with Mycobacterium avium complex (MAC), four an extrapulmonary tuberculosis caused by Mycobacterium tuberculosis (M. tbc). In general, the tuberculosis was the first severe opportunistic infection, whi
Matsuyama T; Hamamoto Y; Yoshida T; Kido Y; Kobayashi S; Kobayashi N; Yamamoto N; Department of Virology and Parasitology, Yamaguchi University; School of Medicine.
The effect of culture supernatant of MT-2 cells on human immunodeficiency virus (HIV)-producing cells, MOLT-4/HIVHTLV-IIIB cells, was examined. As compared to the effect on MOLT-4 cells, parent cells not infected with HIV, a selective cytotoxic/cytostatic effect on MOLT-4/HIVHTLV-IIIB cells was observed 4 days after t
Alsina A; Mason M; Uphoff RA; Riggsby WS; Becker JM; Murphy D; Department of Microbiology, University of Tennessee, Knoxville; 37996.
Candida utilis was cultured from the blood of a patient with acquired immunodeficiency syndrome. The candidemia was apparently associated with catheter implantation. The isolate was identified initially by standard methods and verified by molecular probing. The pattern of actin-specific restriction fragments obtained
Tersmette M; de Goede RE; Al BJ; Winkel IN; Gruters RA; Cuypers HT; Huisman HG; Miedema F; Central Laboratory, The Netherlands Red Cross Blood Transfusion; Service, Amsterdam.
Human immunodeficiency virus isolates were studied with respect to syncytium-inducing capacity, replicative properties, and host range. Five of 10 isolates from patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex were able to induce syncytia in cultures of peripheral blood mononuclear cell
Ann Intern Med. 1988 Jun;108(6):797-9. Unique Identifier : AIDSLINE MED/88220869
Goldsmith GH Jr; Baily RG; Brettler DB; Davidson WR Jr; Ballard JO; Driscol TE; Greenberg JM; Kasper CK; Levine PH; Ratnoff OD; Department of Medicine, University Hospitals of Cleveland, Ohio.
Five patients with classic hemophilia were found to have primary pulmonary hypertension, a disorder not previously recognized in this population. All patients had had their coagulation disorder treated for 10 years or more with self-administered lyophilized concentrates of factor VIII, and all had antibodies to human
Malu K; Longo-Mbenza B; Lurhuma Z; Odio W; Cliniques universitaires du Mont-Amba, service de cardiologie,; Zaire.
In order to evaluate the frequency and clinical features of pericarditis caused by the HIV virus, 17 patients (mean age 28 years) presenting with pericarditis were investigated at the University Clinics of Mont-Amba ( Zaire ), between January, 1985 and December, 1986. The clinical d
AIDS Res Hum Retroviruses. 1987;3(4):423-32. Unique Identifier : AIDSLINE MED/88192940
Puppo F; Pierri I; Rogna S; Pattarini R; Piovano PL; Catellani S; Varnier OE; Indiveri F; Cattedra di Patologia Medica RR, ISMI, University of Genova,; Italy.
In the present study both responsiveness and stimulatory capacity in autologous mixed lymphocyte reactions (AMLRs) of non-T/T and T/T type, as well as in allogeneic mixed lymphocyte reaction (MLR), were evaluated in 30 intravenous drug abusers (IDAs) infected by the human immunodeficiency virus (HIV) and in 10 HIV-neg
Ekholm S; Simon JH; Department of Radiology, University of Rochester Medical Center,; New York 14642.
It is now recognized that patients infected by the virus linked to the acquired immunodeficiency syndrome (AIDS) can develop dementia symptoms as the initial and sometimes only symptomatology for AIDS. This appears to be a syndrome whose origin is independent of secondary non-viral
Cooper DA; Tindall B; Wilson EJ; Imrie AA; Penny R; Centre for Immunology, St. Vincent's Hospital, Sydney, Australia.
The present study was undertaken to determine T cell response to primary human immunodeficiency virus (HIV) infection. No significant difference in T cell subsets was found between subjects who later seroconverted and a group of controls. Six subjects had multiple enumerations of T cell subsets done at the time of ser
Rogers P; Allegra CJ; Murphy RF; Drake JC; Masur H; Poplack DG; Chabner BA; Parrillo JE; Lane HC; Balis FM; Department of Critical Care Medicine, National Cancer Institute,; Bethesda, Maryland 20892.
The combination of the lipophilic antifolate trimetrexate and the rescue agent leucovorin has shown promise in the treatment of Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome. The pharmacokinetic behavior of trimetrexate administered either by intravenous bolus or orally was studied
Schechter MT; Boyko WJ; Craib KJ; McLeod A; Willoughby B; Douglas B; Constance P; O'Shaughnessey M; Vancouver Lymphadenopathy-AIDS Study Group, St Paul's Hospital,; Canada.
The long-term effects of HIV infection were evaluated by comparing data from two visits a mean of 18 months apart in groups of 148 persistently seropositive and 287 persistently seronegative homosexual men. At each visit, the seropositive men exhibited lower CD4 counts, CD4/CD8 ratios, hemoglobin concentrations and ly
Jouvin MH; Rozenbaum W; Russo R; Kazatchkine MD; Unite d'Immunopathologie, Hopital Broussais, Paris, France.
Expression of the C3b/C4b receptor (CR1) was studied on erythrocytes of 153 individuals infected with HIV and 104 age-matched normal individuals by measuring the uptake of 125I-labelled monoclonal anti-CR1 antibody. The mean number of CR1 sites on erythrocytes of asymptomatic seropositive individuals (822 +/- 270; mea
AIDS Res Hum Retroviruses. 1988 Apr;4(2):115-20. Unique Identifier : AIDSLINE MED/88209360
Reddy MM; Grieco MH; R.A. Cooke Institute of Allergy, St. Luke's/Roosevelt Hospital; Center, New York, NY.
Soluble interleukin-2 receptor (SIL-2R) levels in sera were quantitated in asymptomatic intravenous drug abusers (IVDA) and in patients with lymphadenopathy or AIDS. The mean SIL-2R level in serum of normal controls was 158 +/- 19 compared to 368 +/- 35 U/ml in serum of HIV-seronegative asymptomatic IVDA. The mean SIL
Cell. 1988 May 6;53(3):483-96. Unique Identifier : AIDSLINE MED/88210473
Stevenson M; Meier C; Mann AM; Chapman N; Wasiak A; Department of Pathology and Microbiology, University of Nebraska; Medical Center, Omaha 68105.
Masking of host cell receptors following retroviral infection is the basis for the phenomenon of virus interference. Amphotropic retrovirus vectors were used to express the HIV envelope glycoprotein in a human CD4+ cell line. Envelope expression is accompanied by a reduction in the level of surface CD4 receptor molecu
The binding of antibody to the CD4 molecule inhibits mobilization of cytoplasmic free calcium ([Ca2+]i) in response to CD3 cross-linking on resting T cells. Similarly, when CD3 and CD4 are independently and simultaneously cross-linked, calcium mobilization is inhibited when compared to that induced by cross-linking CD
Ochs HD; Junker AK; Collier AC; Virant FS; Handsfield HH; Wedgwood RJ; Department of Pediatrics, School of Medicine, University of; Washington, Seattle 98195.
Persistent, generalized lymphadenopathy (PGL) is a recognized component of human immunodeficiency virus (HIV) infection. We conducted longitudinal studies of B and T cell function in seven homosexual men with HIV infection and PGL. All seven had abnormal antibody-mediated immunity as studied by sequential assessment o
In vitro studies have shown that trimetrexate, a lipid-soluble analogue of methotrexate, is 1500 times more potent than trimethoprim as an inhibitor of dihydrofolate reductase from Pneumocystis carinii. Furthermore, trimetrexate is readily taken up by P carinii, while performed folates such as leucovorin are not. Thes
Krust B; Laurent AG; Le Guern A; Jeannequin O; Montagnier L; Hovanessian AG; Unite d'Oncologie Virale, Institut Pasteur, Paris, France.
HIV-1 infected Molt4-T4 cells provide an efficient system for the production of cellular precursor gp160 of HIV envelope glycoproteins, gp120 and gp41. The precursor gp160 was purified on an immuno-affinity column containing antibodies from sera of HIV-1-seropositive patients. The precursor gp160 was then isolated by
AIDS Res Hum Retroviruses. 1987;3(4):387-400. Unique Identifier : AIDSLINE MED/88192937
Pyle SW; Bess JW Jr; Robey WG; Fischinger PJ; Gilden RV; Arthur LO; Program Resources, Inc., Frederick Cancer Research Facility; (NCI-FCRF), MD 21701.
The outer envelope glycoprotein, gp120, has been purified from large volumes (greater than 100 liters) of HTLV-IIIB-infected H9 cell culture fluids using immunoaffinity chromatography resins prepared from immunoglobulins of AIDS patients plasma. By using a single-step immunoaffinity purification, between 7 and 28 micr
AIDS Res Hum Retroviruses. 1987;3(4):401-8. Unique Identifier : AIDSLINE MED/88192938
Robey WG; Nara PL; Poore CM; Popovic M; McLane MF; Barin F; Essex M; Fischinger PJ; Abbott Laboratories, Abbott Park, IL 60064.
The most variable proteins, the gp120 s, of the many isolates of HIV-I can be readily compared by two-dimensional oligopeptide maps. The gp120 in a given cell line is completely stable, but the cell line defines the actual gp120 size and may induce minor peptide changes. HTLV-IIIB and LAV differ slightly from each oth
AIDS Res Hum Retroviruses. 1987;3(4):409-22. Unique Identifier : AIDSLINE MED/88192939
Lyerly HK; Reed DL; Matthews TJ; Langlois AJ; Ahearne PA; Petteway SR Jr; Weinhold KJ; Department of Surgery, Duke University Medical Center, Durham, NC; 27710.
Cytophilic antibodies which mediate antibody dependent cellular cytotoxicity (ADCC) against envelope antigens of human immunodeficiency virus (HIV) can be found in seropositive individuals. In these experiments, sera from a wide spectrum of HIV infected patients ranging from asymptomatic to overt acquired immunodefici
Shapiro RS; McClain K; Frizzera G; Gajl-Peczalska KJ; Kersey JH; Blazar BR; Arthur DC; Patton DF; Greenberg JS; Burke B; et al; Department of Pediatrics, University of Minnesota Hospital and; Clinic, Minneapolis 55455.
B cell lymphoproliferative disorders (BLPD) developed in eight patients following bone marrow transplantation (BMT) for leukemia (five patients) or immunodeficiency (three patients). Recipients of T depleted marrow from a mismatched donor were at particularly high risk of this complication. Six of 25 (24%) recipients
Oksenhendler E; Bierling P; Brossard Y; Schenmetzler C; Girard PM; Seligmann M; Clauvel JP; Department of Immunohematology, Institut National de la Sante et; de la Recherche Medicale U108, Paris, France.
The potential hazards of steroids in human immunodeficiency virus (HIV)-infected patients led us to evaluate the effectiveness and safety of anti-D and anti-c Ig in 17 adults with severe HIV-related immune thrombocytopenic purpura (platelet count less than 20 x 10(9)/L). The 14 Rh+ patients received 12 to 25 microgram
Jones MP; Gunapala DE; Matutes E; Catovsky D; Coates AR; Department of Medical Microbiology, London Hospital Medical; College, England.
Culture supernatant from a human T-cell leukemia virus type I (HTLV-1)-infected cell line, DGA-1, contained a novel macrophage-activating factor (MAF). This MAF was antigenically and functionally distinct from interferon-gamma (IFN-gamma) and from granulocyte-monocyte colony-stimulating factor (GMCSF). Potential conta
Rosenblatt JD; Chen IS; Golde DW; Department of Medicine, UCLA School of Medicine.
HTLV-II is a rarely encountered human retrovirus that has been linked to atypical presentations of hairy-cell leukemia, as well as a variety of T-cell malignancies. Recently, HTLV-II prevalence has increased in the United States , particularly in populations of intravenous drug abusers.
J Immunol. 1988 May 1;140(9):3006-13. Unique Identifier : AIDSLINE MED/88199049
Bermudez LE; Young LS; Kuzell Institute for Arthritis and Infectious Diseases, Medical; Research Institute at Pacific Presbyterian Medical Center, San; Francisco, CA 94115.
Organisms belonging to the Mycobacterium avium complex (MAC) are the most common bacterial pathogens in patients with AIDS but factors associated with the activation of cellular defense mechanisms against this atypical mycobacterium have not been defined. Peritoneal macrophages harvested from a chronic MAC infection i
Liquori AM; Sadun C; Battisti A; Dipartimento di Scienze e Tecnologie Chimiche, II Universita di; Roma, Italy.
Fourier analysis, previously introduced by Liquori et al. (1983, 1986), has been applied to the primary structures of two core proteins of human T-lymphotropic leukemia retroviruses HTLV-I and HTLV-II. The resulting autocorrelation functions display striking patterns that can be interpreted in terms of an approximatel
Walsh TJ; Pediatric Branch, National Cancer Institute, Bethesda, Maryland.
Systemic fungal infections are life-threatening diseases that are occurring with increasing frequency, especially in immunocompromised patients. Advances in the treatment of systemic fungal infections have been achieved through better understanding of two classic antifungal drugs, amphotericin B and flucytosine, and t
Cornblath DR; McArthur JC; Department of Neurology, Johns Hopkins University School of; Medicine, Baltimore, MD.
The most common type of peripheral neuropathy associated with human immunodeficiency virus (HIV) infection, predominantly sensory neuropathy, affects 10-30% of patients with acquired immunodeficiency syndrome (AIDS). From 40 individuals with peripheral neuropathy and
118 examinations were carried out for non-tumorous diseases of the brain and cervical cord. The sensitivity of MRT was analysed and compared with 77 cases where CT had been performed or with sonography in children. MRT showed an abnormality in 80%, whereas CT or sonography lead to a diagnosis in only 43%. Because of t
Science. 1988 May 13;240(4854):916-9. Unique Identifier : AIDSLINE MED/88204938
Rosenblatt JD; Cann AJ; Slamon DJ; Smalberg IS; Shah NP; Fujii J; Wachsman W; Chen IS; Department of Medicine, UCLA School of Medicine.
The human T-cell leukemia virus (HTLV) types I and II have two nonstructural genes that are encoded in overlapping reading frames. One of these genes, known as tax, has been shown to encode a protein responsible for enhanced transcription (transactivation) from the viral long terminal repeats (LTRs). Genetic evidence
Zhang XL; Langford A; Becker J; Rabanus JP; Pohle HD; Reichart P; Gelderblom H; Institute of Stomatology, Beijing Medical University, P.R. China.
Three cases of HL from the lateral border of the tongue of male homosexual AIDS patients were investigated by thin section electron microscopy. Keratinocytes contained condensed chromatin in their pyknotic nuclei and a few organelles in the oedematous cytoplasm. Chromatin was in close association to the nuclear membra
Lin JC; Zhang ZX; Smith MC; Biron K; Pagano JS; Lineberger Cancer Research Center, School of Medicine, University; of North Carolina, Chapel Hill 27514.
We show that the anti-human immunodeficiency virus agent, 3 -azido-3 -deoxythymidine ( AZT ), which suppresses infectivity and cytopathic effects of human immunodeficiency virus, also effectively inhibits Epstein-Barr virus (EBV) DNA replication. Howeve
Wainberg MA; Blain N; Spira B; Lady Davis Institute for Medical Research, Sir Mortimer B.; Davis-Jewish General Hospital, Montreal, Quebec, Canada.
The addition of both live and ultraviolet-inactivated preparations of human T lymphotropic virus type I (HTLV-I) and HIV to cultures of human peripheral lymphocytes impeded the ability of these cells to respond to phytohaemagglutinin (PHA). This inhibition depended on the concentration of the virus and seemed due, in
AIDS Res Hum Retroviruses. 1988 Feb;4(1):23-30. Unique Identifier : AIDSLINE MED/88209352
Torseth JW; Berman PW; Merigan TC; Department of Medicine, Stanford University School of Medicine,; CA.
Peripheral blood mononuclear cell (PBMC) cultures were established from patients with antibody to human immunodeficiency virus (HIV). Asymptomatically infected patients [5 of 19] had significant lymphocyte transformation responses induced in culture by a purified, recombinant envelope glycoprotein (rgp120) from the vi
AIDS Res Hum Retroviruses. 1988 Feb;4(1):31-41. Unique Identifier : AIDSLINE MED/88209354
Boyd AL; Wood TG; Buckley A; Fischinger PJ; Gilden RV; Gonda MA; Laboratory of Cell and Molecular Structure, Program Resources,; Inc., NCI-Frederick Cancer Research Facility, MD.
An infectious proviral clone of the human immunodeficiency virus (HIV) was microinjected into the cell nucleus in six cell lines derived from caprine, ovine, bovine, or human solid tissue to study the utility of this method in effecting viral gene expression in nonlymphoid cells. Immunofluorescence assays for HIV demo
AIDS Res Hum Retroviruses. 1988 Apr;4(2):107-13. Unique Identifier : AIDSLINE MED/88209359
Mitsuya H; Broder S; Division of Cancer Treatment, National Cancer Institute,; Bethesda, MD 20892.
We have previously shown that 2 ,3 -dideoxynucleosides and their derivatives are potent inhibitors of the infectivity and cytopathic effect mediated by human immunodeficiency virus type-1 (HIV-1), the causative agent of acquired immunodeficiency syndrome (AIDS). Recently a new group of retroviruses has been found in i
EMBO J. 1988 Feb;7(2):519-23. Unique Identifier : AIDSLINE MED/88211565
Hidaka M; Inoue J; Yoshida M; Seiki M; Department of Viral Oncology, Cancer Institute, Tokyo, Japan.
Gene expression of human T-cell leukemia virus type 1 (HTLV-1) is regulated by two trans-acting factors encoded by the pX region, p40tax and p27tax.p40tax is a transcriptional activator and p27rex is a post-transcriptional regulator. Using full-length viral DNA, we studied the regulatory effects of rex on HTLV-1 gene
Nielsen SL; Sorensen I; Andersen HK; Institute of Medical Microbiology, University of Aarhus, Denmark.
Antibody-capture enzyme-linked immunosorbent assay (ELISA) using enzyme-labeled cytomegalovirus ( CMV ) nuclear antigen is a reliable and easily performed test suitable for routine use. As the serologic response to CMV infectio
Heberling RL; Kalter SS; Marx PA; Lowry JK; Rodriguez AR; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, Texas 78284.
A rapid, specific, and sensitive modification of the dot immunobinding assay was compared with the standard enzyme immunoassay as a screening procedure for the detection of antibody in human or simian acquired immunodeficiency syndrome. Comparative testing with the available enzyme immunoassay procedures, either in co
J Med Virol. 1988 Apr;24(4):385-93. Unique Identifier : AIDSLINE MED/88214366
Berry NJ; Burns DM; Wannamethee G; Grundy JE; Lui SF; Prentice HG; Griffiths PD; Department of Virology, Royal Free Hospital, London England.
A total of 731 sera were collected from general hospital patients, divided into five distinct subgroups, and tested for the presence of immunoglobulin (IgG) to cytomegalovirus ( CMV ) and herpes simplex virus (HSV). The results
J Med Virol. 1988 Apr;24(4):435-44. Unique Identifier : AIDSLINE MED/88214371
Wood DJ; David TJ; Chrystie IL; Totterdell B; North Manchester Regional Virus Laboratory, England.
Enteric virus infections were studied in two children with congenital T-cell immunodeficiency. One patient (LC) with cartilage hair hypoplasia developed persistent diarrhea and malabsorption following acute gastroenteritis. Electron microscope (EM) examination of feces revealed excretion of rotavirus for more than 450
J Med Primatol. 1988;17(1):31-40. Unique Identifier : AIDSLINE MED/88214847
Murayama Y; Ishida T; Minezawa M; Noguchi A; Takenaka O; Primate Research Institute, Kyoto University, Aichi, Japan.
A cell line (JAMH17+) resistant to 8-azaguanine was established from a human T-cell leukemia virus type 1 related virus (simian T-cell leukemia virus-1) positive Japanese macaque cell line. Lymphoblastic cell lines were established from the peripheral blood mononuclear cells of humans, hominoids, and several species o
Sauer MK; Donoghue DJ; Department of Biology, University of California, San Diego, La; Jolla 92093.
The protein encoded by v-sis, the oncogene of simian sarcoma virus, is homologous to the B chain of platelet-derived growth factor (PDGF). There are eight conserved Cys residues between PDGF-B and the v-sis protein. Both native PDGF and the v-sis protein occur as disulfide-bonded dimers, probably containing both intra
Clinical, laboratory, and pathologic observations in six patients with sensory motor peripheral neuropathy associated with the acquired immunodeficiency syndrome (AIDS) are presented. Blood and urine testing failed to reveal other causes for peripheral neuropathy. Dis
Pierce GF; Shawver LK; Milner PG; Yeh HJ; Thomason A; Deuel TF; Department of Pathology, Jewish Hospital, St. Louis, Missouri; 63110.
The platelet-derived growth factor (PDGF) is a potent mitogen for cells derived from mesenchyme and is highly related to the transforming protein of the simian sarcoma virus (SSV), p28v-sis. Both PDGF and p28v-sis appear to initiate DNA synthesis and cell proliferation through an interaction with PDGF cell surface rec
Science. 1988 May 20;240(4855):1026-9. Unique Identifier : AIDSLINE MED/88218710
Zack JA; Cann AJ; Lugo JP; Chen IS; Division of Hematology-Oncology, UCLA School of Medicine 90024.
The human immunodeficiency virus type 1 (HIV-1) and human T-cell leukemia virus type I (HTLV-I) are two distinct human retroviruses that infect T cells. Recent epidemiologic studies have identified a cohort of individuals that are coinfected with both viruses. It is reported here that human peripheral blood leukocytes
Klein R; Thiel HJ; Federal Research Center for Virus Diseases of Animals, Tubingen,; Federal Republic of Germany.
Antiserum to human platelet-derived growth factor (PDGF) recognized a simian sarcoma virus transformation-specific glycopeptide, now termed gp200sis, thereby establishing an immunological relationship between PDGF and this highly glycosylated molecule. The same antibodies as well as an antiserum against SSV-NP cells r
Falkner FG; Fuerst TR; Moss B; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892.
A recombinant vaccinia virus that expresses the human immunodeficiency virus (HIV) trans-activator (tat) gene was constructed. The tat polypeptide migrated anomalously with an apparent molecular mass of 14 kDa on a sodium dodecyl sulfate-polyacrylamide gel and reacted with polyclonal anti-tat serum. The tat protein wa
Am J Ophthalmol. 1988 May 15;105(5):483-90. Unique Identifier : AIDSLINE MED/88220490
Fay MT; Freeman WR; Wiley CA; Hardy D; Bozzette S; Department of Ophthalmology, University of California at San; Diego School of Medicine, La Jolla.
We examined three patients with AIDS who had large, sharply demarcated areas of thinned retina consistent with inactive cytomegalovirus retinitis and who were not treated with ganciclovir. These lesions appeared identical to clinically inactive areas of cytomegalovirus retinitis af
Takahashi K; Ohtsuki Y; Sonobe H; Hayashi K; Nakamura S; Kotani S; Kubonishi I; Miyoshi I; Isobe T; Kita K; et al; Department of Pathology, Kochi Medical School, Nankoku, Japan.
We reported a peculiar case with T cell leukemia. The patient was a 34-year-old woman showing extensive splenomegaly and marked leukemic cell proliferation and running a rapid fatal clinical course. The leukemic cells were morphologically ordinary lymphocytes showing suppressor/cytotoxic(s/c) T cell phenotypes and con
Cancer. 1988 May 15;61(10):2060-70. Unique Identifier : AIDSLINE MED/88194263
Su IJ; Wang CH; Cheng AL; Chen YC; Hsieh HC; Chen CJ; Tien HF; Woei-Tsay; Huang SS; Hu CY; et al; Department of Pathology, College of Medicine, National Taiwan; University, Taipei, Republic of China.
Postthymic T-cell malignancy shows marked geographic, clinicopathologic, and prognostic diversity. The frequency and spectrum of T-cell malignancies in Taiwan were investigated. Fifty-two patients (35 male and 17 female) with a medi
Borowitz MJ; Falletta JM; Duke University Medical Center, Durham, North Carolina.
Neoplasms of thymic T-cell derivation include two closely related malignancies: T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma. The recognition of these tumors as distinct biologic entities dates back to the early 1970s, when patients with these diseases were found to have tumor cells th
Kadin ME; Said J; Department of Pathology, Harvard Medical School, Boston,; Massachusetts.
This article describes the heterogeneity of post-thymic T-cell malignancies and correlates specific clinicopathologic entities with morphology and immunophenotype. Peripheral T-cell lymphomas are subclassified into six main histologic types with different prognoses. Special attention is given to the theme of proposed
Ehrlich GD; Poiesz BJ; Division of Hematology/Oncology, SUNY Health Science Center,; Syracuse.
The elucidation of the spread of HTLV-I through high-risk groups and the finite but real incidence of HTLV-I seropositivity in normal blood donor populations in the United States indicates that blood and blood products should be screened for this infectious agent. Because of the abilit
Kedar E; Rezai AR; Giorgi JV; Gale RP; Champlin RE; Mitsuyasu RT; Fahey JL; Department of Microbiology and Immunology, University of; California, Los Angeles.
Mononuclear cells (MNC) derived from peripheral blood (PBMNC) of 23 normal donors and 4 AIDS patients, and from bone marrow (BMMNC) of 15 normal donors were incubated at 37 degrees C in culture medium alone or in the presence of either natural or recombinant human interleukin-2 (
N Engl J Med. 1988 May 5;318(18):1141-7. Unique Identifier : AIDSLINE MED/88202026
Bhagavati S; Ehrlich G; Kula RW; Kwok S; Sninsky J; Udani V; Poiesz BJ; Department of Neurology, State University of New York Health; Science Center at Brooklyn 11203.
The presence of antibodies to human T-cell lymphoma/leukemia virus Type I (HTLV-I) has been associated with chronic progressive myelopathy. We attempted to isolate the virus from the blood and spinal fluid of patients with chronic progressive myelopathy and to define the clinical, radiologic, and electrophysiologic fe
Itoyama Y; Minato S; Kira J; Goto I; Sato H; Okochi K; Yamamoto N; Department of Neurology, Kyushu University, Fukuoka, Japan.
We studied subsets of peripheral blood lymphocytes (PBL) from 12 patients with human T-lymphotropic virus type I (HTLV-I) associated myelopathy (HAM). The percent of OKT8+ cells was significantly decreased, and the percentages of OKDR+ cells and IL-2R+ cells and the ratio of OKT4+ cells to OKT8+ cells were significant
Proc Natl Acad Sci U S A. 1988 May;85(9):3090-4. Unique Identifier : AIDSLINE MED/88203646
Conley ME; Lavoie A; Briggs C; Brown P; Guerra C; Puck JM; Department of Pediatrics, Children's Hospital of Philadelphia,; PA.
X chromosome-linked severe combined immunodeficiency (XSCID) is characterized by markedly reduced numbers of T cells, the absence of proliferative responses to mitogens, and hypogammaglobulinemia but normal or elevated numbers of B cells. To determine if the failure of the B cells to produce immunoglobulin might be du
Williams AE; Fang CT; Slamon DJ; Poiesz BJ; Sandler SG; Darr WF 2d; Shulman G; McGowan EI; Douglas DK; Bowman RJ; et al; American Red Cross Jerome H. Holland Laboratory, Rockville, MD; 20855.
Screening for human T-lymphotropic virus type I (HTLV-I) antibodies was performed on sera from 39,898 blood donors at eight blood centers in geographically distinct areas of the United States . Ten donors (0.025 percent) showed evidence of HTLV-I seropositivity by enzyme immunoassays; t
Am J Med. 1988 May;84(5):919-28. Unique Identifier : AIDSLINE MED/88207377
Kim JH; Durack DT; Department of Medicine, Duke University Medical Center, Durham,; North Carolina 27710.
HTLV-I, the first human oncovirus, is a type C retrovirus linked to the development of ATLL. The virus shows a striking ethnogeographic distribution that is only partially understood. Certain populations at high risk for AIDS appear to have a higher incidence of HTLV-I infection. The extended latent period renders pre
Des Jarlais DC; Friedman SR; Marmor M; Cohen H; Mildvan D; Yancovitz S; Mathur U; el-Sadr W; Spira TJ; Garber J; et al; New York State Division of Substance Abuse Services, NY 10027.
A cohort of 334 intravenous (IV) drug users from New York City drug treatment programs were followed over a mean 9-month period. Among the 165 who were seropositive at enlistment, four developed clinical AIDS, for an annual rate of 3%. Elevated IgA was a significant predictor of developing AIDS. Among 72 subjects who
Cancer Res. 1988 Jun 1;48(11):3148-52. Unique Identifier : AIDSLINE MED/88210306
Yamamoto K; Ono K; Nakahara K; Kitamura K; Yagita H; Okumura K; Department of Internal Medicine and Physical Therapy, Faculty of; Medicine, University of Tokyo, Japan.
During attempts to make antibodies cross-reactive with human lymphocytes, we established a monoclonal antibody (VJ-41) from the alloimmunization of mice, that is, B10.A(3R) anti-B10.A(5R). VJ-41 reacted with all cases of freshly isolated adult T-cell leukemia cells (36 cases) but not with cells from other hematologica
Onuma M; Yasutomi Y; Okada HM; Matsukawa K; Yoshikawa H; Yoshikawa T; Okada K; Takahashi K; Kirisawa R; Kawakami Y; Department of Veterinary Microbiology, Rakuno Gakuen University,; Ebetsu.
Tumor cells from cattle with enzootic bovine lymphosarcoma (EBL) have a tumor-associated antigen (TAA) which is distinct from bovine leukemia virus (BLV)-induced antigens. We were able to sacrifice 8 TAA-positive cattle with no clinical signs of EBL and to examine whether or not they had gross or histological tumors.
Shanson DC; Department of Clinical Microbiology, St. Stephens Hospital,; London.
The widespread screening of donors of blood, organs and semen for HIV antibody has contributed greatly to the prevention of spread of HIV to patients in British hospitals. The chances of patients acquiring HIV from a contaminated blood transfusion are now estimated at less than 1 in 1 million and factor VIII for haemo
Babb JR; Hospital Infection Research Laboratory, Dudley Road Hospital,; Birmingham.
The choice as to which of the two gaseous processes is best suited to individual hospital needs is a difficult one. Very few items are unable to tolerate 73 degrees C (LTSF) and these few can withstand 37 degrees C or 55 degrees C (EO). Unfortunately, LTSF is a moist process and sterilizers have a poor history of pr
Yokota T; Yamada M; Furukawa T; Tsukagoshi H; Department of Neurology, Tokyo Medical and Dental University,; Japan.
A 69-year-old woman with human T-cell lymphotropic virus type I (HTLV-I) positive chronic myelopathy became comatose with acute meningitis. Most of the cells in the cerebrospinal fluid were similar to those found in adult T-cell leukaemia/lymphoma, which suggests that there is a close relationship between HTLV-I and t
LeBoit PE; Berger TG; Egbert BM; Yen TS; Stoler MH; Bonfiglio TA; Strauchen JA; English CK; Wear DJ; Department of Pathology, University of California, San Francisco.
Papular and nodular skin lesions that clinically resembled Kaposi sarcoma, but histologically showed a distinct epithelioid haemangioma-like appearance, were noted in seven patients with the acquired immunodeficiency syndrome. Clusters of bacteria that had the structure of gram-negative rods were identified within eac
Lancet. 1988 May 28;1(8596):1185-8. Unique Identifier : AIDSLINE MED/88215862
Steel CM; Ludlam CA; Beatson D; Peutherer JF; Cuthbert RJ; Simmonds P; Morrison H; Jones M; Medical Research Council Clinical, Edinburgh.
Of 32 patients exposed to a single batch of factor VIII contaminated with human immunodeficiency virus (HIV), 18 became antibody positive. Serial T cell subset analyses over the succeeding four years have shown a progressive decline in circulating T4 cells in those 18 but no change in the 14 who remain seronegative. 2
Proc Natl Acad Sci U S A. 1988 May;85(10):3599-603. Unique Identifier : AIDSLINE MED/88217949
Reddy EP; Mettus RV; DeFreitas E; Wroblewska Z; Cisco M; Koprowski H; Wistar Institute, Philadelphia, PA 19104.
Human T-cell lymphotropic virus type 1 (HTLV-I), the etiologic agent of human T-cell leukemia, has recently been shown to be associated with neurologic disorders such as tropical spastic paraparesis, HTLV-associated myelopathy, and possibly with multiple sclerosis. In this communication, we have examined one specific
Thomas EK; Weber JN; McClure J; Clapham PR; Singhal MC; Shriver MK; Weiss RA; Chester Beatty Laboratories, Institute of Cancer Research,; London, UK.
The production of neutralizing monoclonal antibodies (MAbs) will permit the exact localization of neutralizing epitopes on the AIDS virus, HIV-1. We describe the properties of seven MAbs to the envelope of the LAV-1 isolate. Five MAbs recognise the central portion of gp110, amino acids 279-472, and four of these are c
AIDS Res Hum Retroviruses. 1987;3(4):343-53. Unique Identifier : AIDSLINE MED/88192933
Laure F; Leonard R; Mbayo K; Lurhuma Z; Kayembe N; Brechot C; Sarin PS; Sarngadharan M; Wong-Staal F; Gallo RC; et al; University Pierre et Marie Curie, Paris, France.
We describe here several African isolates of HIV, compare them to U.S.-European prototype isolates and to each other, correlate the number of isolates with serological results, and provide insights into the disease spectrum associated with HIV infection in Africa. Three of 25 healthy Zairian donors and 54 of 87 Zairia
Cancer Lett. 1988 Apr;39(3):329-38. Unique Identifier : AIDSLINE MED/88194301
Carter LJ; Blakeslee JR Jr; Biotechnology Center, Ohio State University, Columbus 43210.
Chemical agents including 5-iodo-2 -deoxyuridine (IUdR), 4-O-methyl 12-O-tetradecanoyl phorbol-13-acetate (TPA), phorbol, and the tumor promoters teleocidin and TPA were tested for their ability to induce Human T-cell leukemia-lymphoma virus Type I (HTLV-I) expression in the low-virus producer MT-1 cell line and in th
Human immune deficiency virus (HIV) replicates by conversion of the RNA genome into the double-stranded DNA provirus. The reverse transcriptase is not the only enzymatic function crucial in DNA-provirus synthesis. A viral-coded RNase H activity which specifically degrades RNA in RNA-DNA hybrids has been shown to be es
Wondrak EM; Lower J; Kurth R; Paul-Ehrlich-Institut, Frankfurt am Main, Federal Republic of; Germany.
Potential specific inhibitors of HIV RNA-dependent DNA polymerase (RDDP) were examined in an in-vitro test system containing purified HIV-1 RDDP, or functionally purified cellular DNA-dependent DNA polymerases alpha, beta and gamma. A wide variety of drugs were tested for their specific inhibitory activity against the
J Immunol. 1988 May 15;140(10):3389-93. Unique Identifier : AIDSLINE MED/88198978
Rinaldo C; Piazza P; Wang YZ; Armstrong J; Gupta P; Ho M; Petteway S; Reed D; Lyter D; Kingsley L; Department of Pathology, University of Pittsburgh, School of; Medicine, PA 15261.
Specific cellular immune responses to human immunodeficiency virus type 1 (HIV-1) were assessed in mononuclear leukocyte cultures from homosexual men with documented, early phase HIV-1 infection. Cell cultures from men with a mean duration of 1.3 yr (range, 0.3 to 2.2 yr) of HIV-1 infection were treated with UV-inacti
Bekesi JG; Tsang PH; Wallace JI; Roboz JP; Department of Neoplastic Diseases, Mount Sinai School of Medicine; and Hospital, City University, New York, N.Y. 10029.
We have evaluated the immunomodulatory effects of isoprinosine in a double blind randomized clinical study on 63 immunosuppressed male homosexuals with persistent generalized lymphadenopathy (PGL) or ARC. The subjects received either placebo or isoprinosine at 1 or 3 g/day for 28 days. All subjects were monitored for
Mitrou PS; Fischer C; Huhn D; Rasokat H; Ring J; Bergmann L; Zentrum der Inneren Medizin der Universitat, Abteilung fur; Hamatologie/Onkologie, Frankfurt/M, FRG.
The design of a prospective phase-II study on the treatment of Kaposi s sarcoma (KS) in patients with HIV infection is described. In this study the toxicity and antineoplastic activity of high-dose alpha-interferon (20 x 10(6) U/m2 s.c. daily) will be investigated in patients with advanced and progressive KS. Patients
Proc Natl Acad Sci U S A. 1988 May;85(9):3105-9. Unique Identifier : AIDSLINE MED/88203649
Takahashi H; Cohen J; Hosmalin A; Cease KB; Houghten R; Cornette JL; DeLisi C; Moss B; Germain RN; Berzofsky JA; Metabolism Branch, National Cancer Institute, Bethesda, MD 20892.
Because cytotoxic T lymphocytes (CTL) may be important for preventing direct cell-to-cell transmission of human immunodeficiency virus (HIV), the agent responsible for acquired immunodeficiency syndrome, we have begun to investigate the epitope specificity and immune response (Ir) gene control of anti-HIV CTL response
Proc Natl Acad Sci U S A. 1988 May;85(9):3198-202. Unique Identifier : AIDSLINE MED/88203668
Rusche JR; Javaherian K; McDanal C; Petro J; Lynn DL; Grimaila R; Langlois A; Gallo RC; Arthur LO; Fischinger PJ; et al; Repligen Corporation, Cambridge, MA 02139.
Antisera to recombinant human immunodeficiency virus (HIV) proteins containing the entire envelope, gp160, or the central portion of the envelope, PB1, can inhibit fusion of virally infected cells in culture. This fusion inhibition is HIV-variant specific--that is, anti-gp160-IIIB inhibits fusion of isolate HTLV-IIIB-
Mitsuya H; Looney DJ; Kuno S; Ueno R; Wong-Staal F; Broder S; Clinical Oncology Program, National Cancer Institute, Bethesda,; MD 20892.
The first step in the infection of human T lymphocytes by human immunodeficiency virus type 1 (HIV-1) is attachment to the target cell receptor, the CD4 antigen. This step may be vulnerable to attack by antibodies, chemicals, or small peptides. Dextran sulfate (molecular weight approximately 8000), which has been give
Z Naturforsch [C]. 1987 Nov-Dec;42(11-12):1328-34. Unique Identifier : AIDSLINE MED/88206344
Gelderblom H; Reupke H; Winkel T; Kunze R; Pauli G; Robert Koch-Institut des Bundesgesundheitsamtes, Berlin.
Immunoelectron microscopy was applied to study the antigenic make-up of human and simian immunodeficiency viruses (HIV, SIV) grown in cells expressing either MHC class I (Molt-3) or MHC class I and II (H9) antigens. A variety of antibodies directed against the surface glycoprotein gp120 of HIV and against MHC class I
AIDS Res Hum Retroviruses. 1988 Feb;4(1):17-22. Unique Identifier : AIDSLINE MED/88209351
DeVico AL; Veronese FD; Lee SL; Gallo RC; Sarngadharan MG; Department of Cell Biology, Bionetics Research, Inc., Rockville,; MD.
The HIV immunoblot profiles of 700 HIV-antibody-positive sera were examined to determine the frequency of antibody reactivity with p66/p51, the reverse transcriptase of HIV. We report a remarkably high seroprevalence of antibodies to p66/p51, detected in 79% of the sera. Only gp41 is recognized more frequently in thes
AIDS Res Hum Retroviruses. 1988 Feb;4(1):43-50. Unique Identifier : AIDSLINE MED/88209355
Cheynier R; Soulha M; Laure F; Vol JC; Reveil B; Gallo RC; Sarin PS; Zagury D; Universite Pierre et Marie Curie, Paris, France.
Acquired immune deficiency syndrome (AIDS) is an immunosuppressive disease associated with the depletion of T4 lymphocytes. Recently, an HIV-1 genome was molecularly cloned and shown to be fully infectious in vitro by transfection experiments. In this study, we show that HIV-1 can be transfected into T4 and T8 lymphoc
Calabrese LH; Department of Rheumatic and Immunologic Disease, Cleveland Clinic; Foundation, Ohio.
The human immune deficiency virus (HIV) is not only capable of inducing a state of immunodeficiency, but it is also associated with a state of profound immune dysregulation. This immune dysregulation may manifest itself as autoimmune reactivity that may participate in the overall pathogenic process of HIV infection as
Chung Hua Min Kuo Wei Sheng Wu Chi Mien I Hsueh Tsa Chih. 1987 Nov;20(4):290-4. Unique Identifier : AIDSLINE MED/88211307
Tseng BW; Chue NW; Chen KT; Department of Internal Medicine, Nan-Men General Hospital,; Shin-Chu City, ROC.
Antibody profiles for hepatitis B virus (HBV), hepatitis A virus (HAV), cytomegalovirus ( CMV ), Epstein-Barr virus (EBV) and human immunodeficiency virus (HIV) were determined on 55 serum samples collected from patients with c
Gregersen JP; Wege H; Preiss L; Jentsch KD; Research Laboratories of Behringwerke AG, Marburg, F.R.G.
A micromethod for the detection of human immunodeficiency virus (HIV) and other retroviruses in cell culture supernatants is described which applies a DEAE ion exchanger for recovery of polynucleotides synthesized in vitro by the retroviral reverse transcriptase. Cell culture, sample preparation, and test performance
Ruffault A; Genetet N; Berthier AM; Pommereuil M; Duvail C; Andre P; Morel H; Genetet B; Fauconnier B; Laboratoire de Virologie, Centre Hospitalier Regional, Rennes,; France.
The interferon (IFN) system, both serum IFN levels and the in vitro IFN production, was investigated in 38 clinically asymptomatic multitransfused hemophiliacs, half positive and half negative for HIV antibodies. In most patients, no circulating IFN was detected; similar levels of IFN-alpha were obtained after periphe
Matsushita S; Robert-Guroff M; Rusche J; Koito A; Hattori T; Hoshino H; Javaherian K; Takatsuki K; Putney S; Second Department of Internal Medicine, Kumamoto University; Medical School, Japan.
A monoclonal antibody was produced to the exterior envelope glycoprotein (gp120) of the human T-cell lymphotropic virus (HTLV)-IIIB isolate of the human immunodeficiency virus (HIV). This antibody binds to gp120 of HTLV-IIIB and lymphadenopathy-associated virus type 1 (LAV-1) and to the surface of HTLV-IIIB- and LAV-1
Garavelli PL; Astori MR; Universita degli Studi di Pavia, Istituto di Clinica delle; Malattie Infettive.
AIDS is characterised by the onset of opportunistic infections and/or neoplasms usually of the lungs, digestive tract and CNS. Eye involvement is less common but takes the form of Kaposi s sarcoma on the eyelids and conjunctiva and retinitis that may be aspecific or caused by
Weiss BD; Department of Family and Community Medicine, University of; Arizona College of Medicine, Tucson.
All physicians, even those not routinely involved in prenatal care, should be aware of the laboratory tests recently recommended for inclusion in prenatal care. All pregnant women should undergo blood glucose testing to detect gestational diabetes mellitus. Women at risk for hepatitis B, Chlamydia trachomatis infectio
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