Three-dimensional similarity mapping reveals nucleotide sequence relationships among human immunodeficiency virus (HIV) isolates. NLM AIDSLINE Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

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Three-dimensional similarity mapping reveals nucleotide sequence relationships among human immunodeficiency virus (HIV) isolates.

Gene. 1987;57(2-3):247-53. Unique Identifier : AIDSLINE MED/88084432
Lott TJ; Plikaytis BD; Benson J; Srinivasan A; Kalyanaraman VS; Division of Mycotic Diseases, Centers for Disease Control,; Atlanta, GA 30329.

Abstract: A method has been developed to compare and graphically display comparisons between many related nucleotide sequences. Principal coordinate analysis, a multidimensional scaling technique, was used to display DNA homology data in three dimensions. Using these methods, an analysis of the env, gag, and gag/pol overlapping regions of human immunodeficiency virus (AIDS virus) clearly demonstrates a clustering of North American isolates relative to African isolates. Elements of the latter group are dissimilar to one another and to the North America group. For the env region, the North American isolates can be resolved into two distinct groups.
Keywords: Base Sequence Comparative Study DNA, Viral/GENETICS Evolution Genes, Viral HIV/*GENETICS Support, Non-U.S. Gov't Variation (Genetics) JOURNAL ARTICLE

KWDbasesequencecomparativestudydna,viral/geneticsevolutiongenes,viralhiv/KWDgeneticssupport,non-uKWDsKWDgov'tvariation(genetics)journalarticle
880430
M8840432

Copyright © 1988 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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