Tumor necrosis factors alpha and beta in acquired immunodeficiency syndrome (AIDS) and aids-related complex. NLM AIDSLINE Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

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Tumor necrosis factors alpha and beta in acquired immunodeficiency syndrome (AIDS) and aids-related complex.

J Clin Immunol. 1987 Nov;7(6):481-5. Unique Identifier : AIDSLINE MED/88087771
Ammann AJ; Palladino MA; Volberding P; Abrams D; Martin NL; Conant M; Department of Medicine, University of California Medical Center,; San Francisco.

Abstract: Human immunodeficiency virus (HIV) infection is associated with abnormalities of both T-cell and B-cell immunity in patients with acquired immunodeficiency syndrome (AIDS). Previous studies demonstrated deficient production of the cytokines interleukin-1 (IL-1), interleukin-2 (IL-2), and gamma interferon (IFN-gamma). Tumor necrosis factor alpha and tumor necrosis factor beta have not been previously investigated in AIDS. In this study we demonstrate that peripheral blood mononuclear cells from patients with HIV infection who have either AIDS-related complex or acquired immunodeficiency syndrome are deficient in the production of tumor necrosis factor alpha and tumor necrosis factor beta. These cytokines, derived predominantly from monocytes or lymphocytes, respectively, function as immunoregulatory, antitumor, and antiinfective proteins. A deficiency in their production may therefore be responsible for many of the complications associated with HIV infection in patients with AIDS-related complex or acquired immunodeficiency syndrome.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY AIDS-Related Complex/IMMUNOLOGY Human Leukocytes, Mononuclear/*METABOLISM Lymphocyte Transformation Support, U.S. Gov't, P.H.S. Tumor Necrosis Factor/*BIOSYNTHESIS JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDimmunologyaids-relatedcomplex/immunologyhumanleukocytes,mononuclear/KWDmetabolismlymphocytetransformationsupport,uKWDsKWDgov't,pKWDhKWDsKWDtumornecrosisfactor/KWDbiosynthesisjournalarticle
880430
M8840422

Copyright © 1988 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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