Names, addresses, and telephone numbers of officials in the federal governments; federal regions; state, county, and city governments; and international. Current as of Jan. 1, 1987.
Mansell PW; Dept. of Clinical Cancer Prevention, Univ. of Texas System Cancer; Center, M.D. Anderson Hosp. and Tumor Inst., Houston, TX
Acquired immune deficiency syndrome (AIDS) is reviewed, including its etiology and epidemiology, incidence, and associated diseases, such as Kaposi s sarcoma, non-Hodgkin s lymphoma , Pneumocystis carinii pneumonia, atypical mycobacterial diseases, disseminated candidiasis, CNS comp
Third International Conference on AIDS. June 1-5, 1987, Washington, DC, U.S. Department of Health and Human Services, and World Health Organization, 236 p., 1987.. Unique Identifier : AIDSLINE ICDB/88633318
Anonymous; No affiliation given
The Third International Conference on Acquired Immunodeficiency Syndrome (AIDS), held June 1-5, 1987, in Washington, DC, included sessions on papers, posters, and roundtable discussions. Abstracts of papers and posters are presented on the following topics: AIDS epidemiology, virology, molecular biology, immunology, s
Yarchoan R; Broder S; Clinical Oncology Program, Div. of Cancer Treatment, NCI,; Bethesda, MD
A status report on the development of antiviral therapy for human T-cell lymphotropic virus type III (HTLV-III)-induced diseases is presented. In particular, the theoretical basis is outlined for using antiviral agents in AIDS (acquired immunodeficiency syndrome). A strategy is described for identifying drugs that may
Lenoir GM; Bornkamm GW; International Agency for Res. on Cancer, 69372 Lyon Cedex 08,; France
Evidence supporting a multistep scenario for the development of Burkitt s lymphoma (BL), focusing on the Epstein-Barr virus (EBV)-associated BL that occurs in areas in Africa, is reviewed. In view of new knowledge gained from molecular studies, from studies of acquired immunodeficiency syndrome (AIDS)/BL cases, and of
This volume contains abstracts of papers and posters presented at a conference on mechanisms of control of gene expression, held March 29-April 4, 1987, as one of the annual UCLA Symposia on Molecular and Cellular Biology. Conference participants reported findings in sessions on the following topics: gene regulation i
Progress in Immunology VI. Sixth International Congress of Immunology. Cinader B, Miller RG, eds. New York, Academic Press, p. 664-74, 1986.. Unique Identifier : AIDSLINE ICDB/88640042
Melief CJ; Zijlstra M; Vasmel WL; Matthews E; Slater RM; Berns AM; The Netherlands Cancer Inst., Antoni van Leeuwenhoek Huis, 1006; CX Amsterdam, The Netherlands
Molecular genetic mechanisms of lymphoma induction by retroviruses (RVs) are discussed under the following headings: structure of lymphomagenic RVs, modes of transmission of lymphomagenic RVs, RV insertions in the vicinity of cellular oncogenes (RV insertional mutagenesis of the c-myc gene by avian leukosis virus and
Brandonisio O; Angarano G; Altamura M; Locaputo S; Pastore G; Canestri-Trotti G; Istituto di Microbiologia Medica, Facolta di Medicina e; Chirurgia, Universita di Bari.
A case of cryptosporidiosis in a male homosexual man with AIDS is reported. The clinical manifestations were anorexia, mild fever, abdominal pain and profuse watery diarrhea. The diagnosis was made in fecal smears by using a modified Ziehl-Neelsen method and a safranin-methylene blue staining technique.
Ruszczak Z; Mayer da Silva A; Orfanos CE; Department of Dermatology, University Medical Center Steglitz,; Free University of Berlin.
In clinically noninvolved skin from the area surrounding early macular lesions of AIDS-associated disseminated Kaposi s sarcoma (KS), morphological evidence of vascular proliferation was seen in the upper papillary dermis. Poorly differentiated cells with cytoplasmic inclusions similar to Weibel-Palade bodies were fou
Lott TJ; Plikaytis BD; Benson J; Srinivasan A; Kalyanaraman VS; Division of Mycotic Diseases, Centers for Disease Control,; Atlanta, GA 30329.
A method has been developed to compare and graphically display comparisons between many related nucleotide sequences. Principal coordinate analysis, a multidimensional scaling technique, was used to display DNA homology data in three dimensions. Using these methods, an analysis of the env, gag, and gag/pol overlapping
Hosp Community Psychiatry. 1987 Dec;38(12):1299-303. Unique Identifier : AIDSLINE MED/88085034
Baer JW; Hall JM; Holm K; Lewitter-Koehler S; Department of Psychiatry, San Francisco General Hospital,; California 94110.
The presence of patients with AIDS and AIDS-related complex (ARC) on a psychiatric unit requires education of and adaptation by staff and other patients as well as changes in the psychiatric milieu. The authors describe their experiences with 36 AIDS and ARC patients admitted to a psychiatric unit over an 18-month per
Ammann AJ; Palladino MA; Volberding P; Abrams D; Martin NL; Conant M; Department of Medicine, University of California Medical Center,; San Francisco.
Human immunodeficiency virus (HIV) infection is associated with abnormalities of both T-cell and B-cell immunity in patients with acquired immunodeficiency syndrome (AIDS). Previous studies demonstrated deficient production of the cytokines interleukin-1 (IL-1), interleukin-2 (
Montalban C; Sevilla F; Moreno A; Nash R; Celma ML; Munoz RF; Department of Internal Medicine, Centro Especial Ramon y Cajal,; Madrid, Spain.
We describe the case of a woman aged 34 years infected with the human immunodeficiency virus and whose illness was complicated by visceral leishmaniasis that ultimately led to her death.
Benotti PN; Jenkins RL; Cady B; O'Hara C; Groopman JE; Harvard Medical School, New England Deaconess Hospital, Boston,; Massachusetts.
Sixty patients considered at risk for acquired immune deficiency syndrome (AIDS) were referred for evaluation of generalized lymphadenopathy. All patients were seropositive for antibody to human T-lymphotropic virus type III (HTLV-III). Multiple lymph node biopsies from different nodal areas were performed. The result
Med Care. 1987 Aug;25(8):675-85. Unique Identifier : AIDSLINE MED/88092988
Richardson JL; Lochner T; McGuigan K; Levine AM; Department of Preventive Medicine, School of Medicine, University; of Southern California, Los Angeles.
The number of patients with acquired immunodeficiency syndrome (AIDS) continues to increase. These patients require medical care from physicians who are well trained and who are willing to provide that care. In 1985, we undertook a survey of 314 heterosexual and homosexual physicians in Los Angeles County to determine
Wilmes E; Gurtler L; Klinik und Poliklinik fur HNO-Kranke der Universitat Munchen.
In comparison to sexual contact the transmitted droplet infection or the mucosa contact are of minor relevance for HIV, the causative agent of acquired immune deficiency (AIDS). These channels of infections should nevertheless not be disregarded. Due to his activity, connected with a very close contact with exudations
Moller B; Hopf U; Poschke S; Alexander M; Friedrich-Jahnicke B; Mostertz P; L'age M; Medizinische Klinik des Universitatsklinikums, Charlottenburg,; Frele Universitat Berlin, Federal Republic of Germany.
Treatment of serum precipitates with sodium thiocyanate in patients with hepatitis B virus (HBV) replication results in liberation of circulating hepatitis core antigen (HBcAg) which can be demonstrated radioimmunologically. Follow-up investigations were performed in 80 patients with acute hepatitis B. Sera were exami
Sultan Y; Centre d'Accueil et de Traitement des Hemophiles, Hopital; Cochin, Paris, France.
A total of 27 hemophilia centers treating patients all over France responded to a questionnaire about the progression of HIV infection in multitransfused patients. Information from 2,049 hemophilic patients was collected. The prevalence of HIV infection in French hemophiliacs was 4
Postgrad Med J. 1987 Aug;63(742):677-9. Unique Identifier : AIDSLINE MED/88097008
Greenberg RE; Bank S; Singer C; Department of Medicine, Long Island Jewish Medical Center, New; Hyde Park, NY 11042.
A patient with macroamylasaemia in association with the acquired immunodeficiency syndrome is described. Patients with the acquired immunodeficiency syndrome commonly have gastrointestinal symptoms that often prompt serum amylase determination. Macroamylasaemia has been found to occur in a variety of diseases includin
Henin D; Duyckaerts C; Chaunu MP; Vazeux R; Brousse N; Rozenbaum W; Hauw JJ; Laboratoire de Neuropathologie R. Escourolle, Hopital de la; Salpetriere, Paris.
Post-mortem study of every patient who died from AIDS in Pitie-Salpetrire Hospital from June 1984 to November 1985 was performed without regard to the presence of neurological signs and symptoms. Autopsy were performed in 31/48 cases. Patients had been hospitalized in the Departments of Parasitology-Infectious Disease
Sonnet J; Michaux JL; Zech F; Brucher JM; de Bruyere M; Burtonboy G; Department of Internal Medicine, St-Luc Hospital, University of; Louvain, Brussels, Belgium.
Three retrospectively diagnosed fatal AIDS cases are reported and discussed together with 4 other HIV seropositive patients, who all apparently contracted the HIV infection prior to the beginning of the present outbreak, without any other risk factor than heterosexual exposure in Central Africa. These data and simulta
South Med J. 1987 Dec;80(12):1529-32. Unique Identifier : AIDSLINE MED/88099699
Kory WP; Rico MJ; Gould E; Penneys NS; Department of Pathology, University of Miami School of Medicine,; Fla.
We recently undertook a survey of all patients with acquired immunodeficiency syndrome (AIDS) seen at the University of Miami/Jackson Memorial Medical Center (UM/JMMC) and reviewed all skin biopsies received from these patients. Skin was the second most common organ biopsied; 36% of all patients (78/217) with AIDS had
Biochem Biophys Res Commun. 1987 Dec 16;149(2):693-9. Unique Identifier : AIDSLINE MED/88106493
Robinson WE Jr; Montefiori DC; Mitchell WM; Vanderbilt University School of Medicine, Department of; Pathology, Nashville, TN 37232.
While testing sera for Human Immunodeficiency Virus neutralizing antibody titers, three sera were identified which had the ability to enhance infectivity of the virus. The sera were from three different individuals residing in Nashville, TN. The enhancing factor was not removed by either filtration through 0.05 micron
Cancer Detect Prev Suppl. 1987;1:487-91. Unique Identifier : AIDSLINE MED/88080262
Biggar RJ; Environmental Epidemiology Branch, National Cancer Institute,; Bethesda, MD 20205.
AIDS has existed in subsaharan Africa at least since 1980. However, the genesis of this condition and its emergence as a health problem remain obscured by lack of data and by antibody data that are now questionable. In Africa, as elsewhere, AIDS is associated with an immunodeficiency associated with the LAV/HTLV-III r
Cancer Detect Prev Suppl. 1987;1:501-7. Unique Identifier : AIDSLINE MED/88080264
Daniel MD; Desrosiers RC; Letvin NL; King NW; Schmidt DK; Sehgal P; Hunt RD; New England Regional Primate Research Center, Harvard Medical; School, Southborough, MA 01772.
The macaque immunodeficiency syndrome has many parallels to AIDS in humans. Affected monkeys develop profound, prolonged T lymphocyte dysfunction and die of lymphomas or opportunistic infections. We recently isolated a virus that we call SIV from four sick macaque monkeys. The morphology, growth characteristics, and a
Cancer Detect Prev Suppl. 1987;1:509-14. Unique Identifier : AIDSLINE MED/88080265
Goudsmit J; Gibbs CJ Jr; Asher DM; Gajdusek DC; Virology Department, Academic Medical Center of the University of; Amsterdam, The Netherlands.
Seven of seven chimpanzees inoculated with LAV/HTLV-III and three of three chimpanzee-to-chimpanzee passages seroconverted for LAV/HTLV-III as tested by ELISA and immunoblotting. Serum IgG reactivity to gag-gene products emerged between 3 and 6 weeks after inoculation, p24gag reactivity always reaching maximum titers
Cancer Detect Prev Suppl. 1987;1:535-41. Unique Identifier : AIDSLINE MED/88080269
Fuchs D; Hausen A; Reibnegger G; Schonitzer D; Unterweger B; Blecha HG; Hengster P; Rossler H; Schulz T; Werner ER; et al; Institute of Medical Chemistry and Biochemistry, University of; Innsbruck, Austria.
This study followed 184 drug abusers. Examined in all of them were urinary neopterin levels, HBV, SGOT, and Luestest. Seventy-three percent of IV drug addicts showed elevated neopterin levels reflecting activated cellular immunity. Statistically, no correlation of neopterin levels with, eg, excessive alcohol consumpti
Cancer Detect Prev Suppl. 1987;1:557-65. Unique Identifier : AIDSLINE MED/88080273
Ioachim HL; Cooper MC; Hellman GC; Department of Pathology, Lenox Hill Hospital, New York, NY 10021.
An increased incidence of lymphoid neoplasias is associated with the states of immune deficiency both congenital and acquired. Thirty-five cases of lymphoma in males at high risk for AIDS were diagnosed in one community hospital in New York City within the past 2 years. The mean age of these patients was 39.6 years; 3
Cancer Detect Prev Suppl. 1987;1:567-70. Unique Identifier : AIDSLINE MED/88080274
Hardell L; Moss A; Osmond D; Volberding P; School of Public Health, University of California, Berkeley; 94720.
Fifty male AIDS patients with Kaposi sarcoma and 50 matched controls were interviewed about occupation, exposure to pesticides, Vietnam service, smoking habits, etc. No difference in use of pesticides was seen. One case but no control had served in Vietnam and was thereby exposed
Cancer Detect Prev Suppl. 1987;1:577-82. Unique Identifier : AIDSLINE MED/88080277
Muller H; Falk S; Stutte HJ; Zentrum der Pathologie, J.W. Goethe Universitat, Frankfurt,; Federal Republic of Germany.
Lymph nodes from eight LAS and six AIDS patients were studied by routine histology, immunohistochemistry, and ultraimmunohistochemistry. LAS lymph nodes show a peculiar follicular hyperplasia with a characteristic increase of proliferating dendritic and interdigitating reticulum cells. In AIDS, these cells are reduced
Carini C; D'Amelio R; Mezzaroma I; Aiuti F; Department of Allergy and Clinical Immunology, University of; Rome, La Sapienza, Italy.
Using an ultracentrifugation technique human immunosuppressive virus (HIV) (GP15 and GP41), anti-HIV (anti-GP15 and anti-GP41) immune complexes were detected in the sera of 3 (1 Acquired immune deficiency syndrome (AIDS), 1 AIDS related complex (ARC), 1 Lymphadenopathy syndrome (LAS] out of 6 patients studied. Evidenc
Papadopoulos NM; Costello R; Clinical Chemistry Service, National Institutes of Health,; Bethesda, Maryland 20892.
Analysis of serum samples from 68 healthy subjects seropositive for HTLV-III antibodies was performed by high-resolution zone electrophoresis. A high incidence of oligoclonal immunoglobulin bands was detected in the sera of these subjects compared with absence of these bands in the sera of healthy seronegative control
Rollag H; Evensen SA; Froland SS; Glomstein A; Institute of Bacteriology, Rikshospitalet, Oslo, Norway.
Serial serum samples from the 21 HIV-infected Norwegian hemophiliacs have been assayed for the presence of HIV antigen and antibodies to HIV specific for the core protein p24 and the envelope protein gp41. HIV antigen was detected in 4 patients, of whom 3 have developed AIDS to date. HIV antigen appeared in serum 10 t
As morbidity of thrombopenia in hemophilia A patients is increasing, the pathogenetic influence of the reticuloendothelial system (RES) was measured using autologous anti-Rh0(D)-coated erythrocytes (EA) in 17 patients with or without thrombopenia. Mean survival of EA in patients was reduced to 53% of healthy controls
Mergener K; Enzensberger W; Rubsamen-Waigmann H; von Briesen H; Doerr HW; Department of Medical Virology, University Clinics of Frankfurt,; FRG.
Twenty-four homosexual adult patients suffering from LAS or AIDS were investigated for immunoglobulin class- and IgG subclass-specific antibodies to human immunodeficiency virus (HIV) by the indirect ELISA and Western blot using monoclonal tracer antibodies. All patients revealed HIV-specific serum antibodies of IgG s
Lindhardt BO; Bygbjerg IC; Ulrich K; Petersen HD; Lausen I; Frederiksen B; Laboratory of Tumor Virology, Fibiger Institute, Copenhagen,; Denmark.
A method for elution of HIV antibodies from whole blood or serum impregnated filter paper discs was developed. The results from testing of 73 eluates in an enzyme linked immunosorbent assay and the immunoblotting test agreed with the results obtained by ordinary serum testing. Significant loss of antibody activity was
Koller U; Rumpold H; Schindler J; Schweiger C; Gabl F; Institute of Clinical Chemistry and Laboratory Medicine,; University of Vienna, Austria.
Most material used for control and calibration in a clinical laboratory is based on pool sera of human origin, guaranteed to be HBsAg-free. Since little information is available on the potential infectivity of HIV, the causative agent of acquired immunodeficiency syndrome (AIDS), 54 control and calibration sera, in ro
Schiodt M; Greenspan D; Daniels TE; Greenspan JS; Department of Oral Medicine and Oral Surgery, University; Hospital, Copenhagen, Denmark.
Oral hairy leukoplakia (HL) is a frequent, apparently specific, and early clinical sign of exposure to human immunodeficiency virus. We studied 50 consecutive patients, or whom two had acquired immune deficiency syndrome (AIDS) at the time of diagnosis of HL. AIDS developed in another eight patients during the observa
Krilov LR; Kamani N; Hendry RM; Wittek AE; Quinnan GV Jr; Department of Pediatrics, Schneider Children's Hospital of Long; Island Jewish Medical Center, New Hyde Park, NY 11042.
Kestelyn P; Stevens AM; Bakkers E; Rouvroy D; Van de Perre P; Centre Hospitalier de Kigali, Rwanda.
This report proves the relationship between herpes zoster ophthalmicus and seropositivity for HTLV-III in young and often apparently healthy African patients. The ophthalmologist should screen patients with herpes zoster ophthalmicus for antibodies against HTLV-III in areas where this virus is endemic or if the patien
Cancer Detect Prev Suppl. 1987;1:525-33. Unique Identifier : AIDSLINE MED/88080268
Lunardi Iskandar Y; Georgoulias V; Rozenbaum W; Vittecoq D; Meyer P; Gentilini M; Jasmin C; Unite d'Oncogenese Appliquee (INSERM U-268), Hopital Paul; Brousse, Villejuif, France.
T-cell colonies were generated from the peripheral blood and bone marrow of 61 patients with acquired immunodeficiency syndrome (AIDS), 54 patients with persistent lymphadenopathy syndrome (LAS), 14 clinically normal male homosexuals, and 17 healthy heterosexuals. Mononuclear cells were cultured in methylcellulose in
Cancer Detect Prev Suppl. 1987;1:543-8. Unique Identifier : AIDSLINE MED/88080270
Kekow J; Kern P; Schmitz H; Gross WL; Department of Internal Medicine, Christian Albrecht University,; Kiel, Federal Republic of Germany.
In addition to the well known T-cell dysfunctions in AIDS, hypergammaglobulinaemia and autoimmune phenomena indicate an involvement of the B cell as well. Reports of HTLV-III/LAV-infected B cells suggest T-cell-independent B-cell abnormalities. To look for early B-cell dysfunctions, we examined a high-risk group of AI
Cancer Detect Prev Suppl. 1987;1:583-7. Unique Identifier : AIDSLINE MED/88080278
Fuchs D; Hausen A; Hoefler E; Schonitzer D; Werner ER; Dierich MP; Hengster P; Reibnegger G; Schulz T; Wachter H; Institute for Medical Chemistry and Biochemistry, University of; Innsbruck, Austria.
Urinary neopterin levels are raised with a high incidence in all risk groups for AIDS. Neopterin elevations reflect activated cellular immunity in risk group members, in some cases independently of LAV/HTLV-III infection. Moreover, we are able to show that in patients receiving multiple blood transfusions at least a t
Cancer Detect Prev Suppl. 1987;1:589-96. Unique Identifier : AIDSLINE MED/88080279
Fischbein A; Bekesi JG; Solomon S; Borek E; Sharma OK; Environmental Sciences Laboratory, Mount Sinai School of; Medicine, City University of New York, NY 10029.
Patients with certain malignant diseases excrete in their urine elevated levels of modified nucleosides originating predominantly from the breakdown of transfer RNA (tRNA). Acquired immune deficiency syndrome (AIDS), often associated with rapidly progressing Kaposi s sarcoma (KS), is currently occurring in many countr
Cancer Detect Prev Suppl. 1987;1:619-26. Unique Identifier : AIDSLINE MED/88080282
Hofmann B; Fugger L; Ryder LP; Gaub J; Odum N; Platz P; Gerstoft J; Svejgaard A; Department of Clinical Immunology, University Hospital; (Rigshospitalet) and State Serum Institute, Copenhagen, Denmark.
We studied the effects of exogenous T cell growth factor (TCGF) (= interleukin-2) and indomethacine on the lymphocyte transformation response in vitro to allogeneic cells, mitogens, and antigens in AIDS patients, those with AIDS-related complex (ARC), and in healthy controls. While low amounts of TCGF reduced the resp
Beretta A; Grassi F; Pelagi M; Clivio A; Parravicini C; Giovinazzo G; Andronico F; Lopalco L; Verani P; Butto S; et al; Dipartimento di Biologia e Genetica per le Scienze Mediche,; Universita di Milano.
A serological cross-reactivity between env gp120 glycoprotein of the human immunodeficiency virus (HIV) and a human cellular surface protein has been defined by a monoclonal antibody (M38) raised against HIV. The cellular antigen is a protein of ca. 80 kDa expressed on a small fraction of mononuclear cells in peripher
Romeo MA; Russo Mancuso G; Mauro L; Sciotto A; Romeo MA; Di Gregorio F; Giammanco G; Schiliro G; Istituti di Clinica Pediatrica I, Universita di Catania, Italy.
Antibodies to HTLV-III were found in 6 of 206 Sicilian patients with thalassemia major, aged 1 to 30 years. None of the patients showed clinical signs related to immuno-deficiency syndromes. Immunological investigations carried out in all positive patients showed alterations similar to those found in thalassemic patie
Gupta S; Vayuvegula B; Department of Medicine, University of California, Irvine 92717.
It is well established that the activation of T lymphocytes by mitogen/antigen is accompanied by a rise in intracellular free calcium ([Ca2+]i), changes in membrane potential, metabolism of inositol phospholipid, and activation of protein kinase C. These early events of signal transduction culminate in late events of
Francis ND; Goldin RD; Forster SM; Cook HT; Coleman DV; Shaw R; Pinching AJ; Boylston AW; Department of Histopathology, St Mary's Hospital, London.
One hundred and twenty consecutive bronchoscopic examinations were carried out on 80 patients with acquired immune deficiency syndrome (AIDS) between January 1982 and December 1986. Ninety one paired biopsy and cytology specimens from 72 of these patients were analysed. There was no significant difference between biop
J Immunol. 1987 Dec 15;139(12):4027-33. Unique Identifier : AIDSLINE GENBANK/M18404
Banapour B; Rosenthal K; Rabin L; Sharma V; Young L; Fernandez J; Engleman E; McGrath M; Reyes G; Lifson J; Division of Cellular Immunology, Genelabs Incorporated, Redwood; City, CA 94063.
A human monoclonal antibody (IgG2, lambda), 1B8.env, was produced, reactive with the envelope glycoprotein of human immunodeficiency virus (HIV). The antibody specifically stains cells infected with HIV, as assessed by indirect immunofluorescence analysis and reacts with determinants displayed on the surface of infect
Bye MR; Bernstein L; Shah K; Ellaurie M; Rubinstein A; Division of Pediatric Pulmonary Medicine, Albert Einstein College; of Medicine, Bronx, NY 10461.
Between October, 1985 and May 1987, 29 children (mean age 22 +/- 22 months, range 2-54 months) with AIDS or ARC developed acute respiratory illness. The initial diagnostic procedure was flexible fiberoptic bronchoscopy, with bronchoalveolar lavage (BAL). BAL was positive for Pneumocystis carinii in 14 and for respirat
Proc Natl Acad Sci U S A. 1987 Dec;84(24):9155-9. Unique Identifier : AIDSLINE MED/88097446
Maddon PJ; Molineaux SM; Maddon DE; Zimmerman KA; Godfrey M; Alt FW; Chess L; Axel R; Department of Biochemistry and Molecular Biophysics, College of; Physicians and Surgeons, Columbia University, New York, NY 10032.
The T4 molecule may serve as a T-cell receptor recognizing molecules on the surface of specific target cells and also serves as the receptor for the human immunodeficiency virus. To define the mechanisms of interaction of T4 with the surface of antigen-presenting cells as well as with human immunodeficiency virus, we
87 patients with anti-HIV antibodies were divided into three groups based on the classification of the Centers for Disease Control and the following parameters reflecting polyclonal B cell activation were evaluated in these patients: immunoglobulin levels, circulating immune complexes and occurrence of autoantibodies.
S Afr Med J. 1987 Dec 19;72(12):871-2. Unique Identifier : AIDSLINE MED/88099922
Pincus PS; Sandler MA; Naude GE; Kallenbach JM; Isaacson C; Zwi S; Department of Medicine, Johannesburg Hospital.
Cavitation is a most unusual radiological feature of Pneumocystis carinii pneumonia (PCP). Autopsy evidence of cavities in PCP is poorly documented. We describe a case of fatal PCP occurring in a patient with the acquired immune deficiency syndrome; the PCP was associated with radiological as well as autopsy evidence
Cancer Surv. 1987;6(1):101-15. Unique Identifier : AIDSLINE MED/88080120
Marx PA; Lowenstine LJ; University of California, Davis 95616.
The type D subfamily of retroviruses contains five distinct viruses which are found in New and Old World monkeys. The retroviruses found in Old World macaque (genus Macaca) monkeys are exogenous to the species and upon injection induce a fatal simian acquired immune deficiency syndrome (SAIDS). Two serotypes of type D
Cancer Detect Prev Suppl. 1987;1:457-62. Unique Identifier : AIDSLINE MED/88080259
Pompidou A; Soubrane C; Cour V; Telvi L; Meunier C; Jacquillat C; Hopital Saint-Vincent de Paul, Paris, France.
Immunomodulatory effect of Isoprinosine are presented in melanoma and HTLV-III/LAV infected patients. Isoprinosine (50 mg/kg) was used as a pulse immunotherapy according to two different schedules: A) 5 days every 15 days and B) 5 days every 15 days for 2 months, then 5 days every 2 months. The patients immunological
Cancer Detect Prev Suppl. 1987;1:597-609. Unique Identifier : AIDSLINE MED/88080280
Glasky AJ; Gordon JF; Newport Institute for Medical Research, Newport Beach, CA.
The immunopharmacologic effects of Isoprinosine (INPX) have been associated with clinical benefit to the patient in a number of conditions characterized by immunodeficiency of diverse etiology. Immunodepressed homosexuals at risk of developing acquired immunodeficiency syndrome (AIDS) treated with placebo or INPX expe
Wilber JC; Department of Public Health, San Francisco, California.
This article describes laboratory methods available for testing serum to determine whether a patient is infected with human immunodeficiency virus (HIV). Included is discussion of uses and limitations of the assays, patient counseling, laboratory safety, and interpretation of the test results.
Bishop PE; McMillan A; Gilmour HM; Department of Genito-Urinary Medicine, University of Edinburgh,; UK.
A histological study of the lymphoid tissue of the rectums of 323 homosexual and 30 heterosexual men (including five intravenous drug users seropositive for human immunodeficiency virus, HIV) was undertaken. Marked lymphoid hyperplasia (germinal centre greater than 680 microns in diameter) was found in 13 men, nine of
A commercially available luminescence enhanced enzyme immunoassay (Amerlite--Amersham International) for carcinoembryonic antigen (CEA) was compared with an established enzyme immunoassay (Monoclonal 1-step Assay-- Abbott Laboratories ). A reference range for healthy blood donors (n
J Med Virol. 1987 Dec;23(4):323-9. Unique Identifier : AIDSLINE MED/88089545
Lee YS; Baker L; Lindsley F. Kimball Research Institute, New York Blood Center, NY; 10021.
Human immunodeficiency virus (HIV) is the primary etiological agent of acquired immunodeficiency syndrome (AIDS). This virus can be transmitted by blood or blood products. Homosexual males (HM) are regarded as one of the high-risk groups for AIDS. Lymphocytes obtained from HM were used for cocultivation with fresh HIV
Larson E; Johns Hopkins University School of Nursing, Baltimore, Maryland; 21205.
The changing epidemiology of neonatal infections manifested in the first few weeks of life is described. The six infections discussed are herpes, hepatitis B, chlamydial infection, infection due to the group B streptococcus, gonococcal disease, and acquired immunodeficiency syndrome. Nursing actions to prevent the spr
Pediatr Med Chir. 1987 Jul-Aug;9(4):381-9. Unique Identifier : AIDSLINE MED/88096867
de Martino M; Resti M; Muccioli AT; Galli L; Azzari C; Vierucci A; Clinica Pediatrica III, Universita di Firenze, Italia.
This review will describe the current state of basic knowledge on the acquired immune deficiency syndrome (AIDS), which has now spread worldwide becoming an acute public health problem in western countries and in Africa. AIDS is a viral infection, due to a retrovirus designated human immune deficiency virus (HIV), whi
Pediatr Med Chir. 1987 Jul-Aug;9(4):415-20. Unique Identifier : AIDSLINE MED/88096871
Cocchi P; Calabri G; Salvi G; Nieri RM; de Martino M; Dipartimento di Pediatria dell'Universita di Firenze, Italia.
Since its first report in 1981, acquired immunodeficiency syndrome (AIDS) has attracted great interest among clinicians. Pediatric cases of AIDS were reported only two years later. Recently a review of the literature revealed about 300 pediatric patients with AIDS who are now tabulated separately by the Centers for Di
Pediatr Med Chir. 1987 Jul-Aug;9(4):423-8. Unique Identifier : AIDSLINE MED/88096872
Calabri G; Salvi G; Nieri RM; Cocchi P; Dipartimento di Pediatria dell'Universita di Firenze, Italia.
The principle form of AIDS transmission are well known: sexually, blood and blood products, vertical transmission and in order to prevent HIV infections one must avoid these modes of transmission. Much has done to make more secure blood and blood products used for transfusions. It is furthermore, advised to those who
Proc Natl Acad Sci U S A. 1987 Dec;84(24):8903-6. Unique Identifier : AIDSLINE MED/88097396
Debouck C; Gorniak JG; Strickler JE; Meek TD; Metcalf BW; Rosenberg M; Department of Molecular Genetics, Smith Kline and French; Laboratories, King of Prussia, PA 19406.
The mature gag and pol proteins of human immunodeficiency virus (HIV) and all retroviruses derive from large gag and gag-pol polyprotein precursors by posttranslational cleavage. A highly specific, virally encoded protease is required for this essential proteolytic processing. In this study, the HIV protease gene prod
Huminer D; Rosenfeld JB; Pitlik SD; Department of Internal Medicine C, Beilinson Medical Center,; Petah Tiqva, Israel.
A search of the medical literature published since 1950 disclosed 19 cases of probable AIDS reported before the start of the current epidemic. These cases retrospectively met the Centers for Disease Control s surveillance definition of the syndrome and had a clinical course suggestive of AIDS. The reports originated f
Hrdy DB; Division of Infectious and Immunologic Diseases, University of; California Davis Medical Center, Sacramento 95817.
Differences between the epidemiology of AIDS cases in Africa and that in Western societies have prompted speculation regarding risk factors that may be unique to Africa. Because of the age and sex distribution of AIDS cases in Africa, emphasis has been placed on sexual transmission of human immunodeficiency virus (HIV
Lo B; Raffin TA; Cohen NH; Wachter RM; Luce JM; Hopewell PC; Division of General Internal Medicine, University of California; San Francisco.
AIDS presents ethical dilemmas about intensive care. Even with intensive care the outcome for patients with AIDS is poor. Care givers have no ethical or medical obligation to provide futile care. Decisions concerning competent patients should be made jointly by physicians and the informed patients themselves. For inco
Staib F; Seibold M; Antweiler E; Frohlich B; Weber S; Blisse A; Mycology Unit, Robert Koch Institute, Federal Health Office,; Berlin (West), Federal Republic of Germany.
Cryptococcus neoformans was found as the causative agent of cryptococcosis in 7 (3.6%) out of 195 HIV-positive persons, most of them being hospitalized. These 7 persons included 6 homosexuals and 1 heroin addict. The examinations were performed at the Mycology Unit of the Robert Koch Institute in Berlin (West) between
Biochem Biophys Res Commun. 1987 Dec 16;149(2):562-7. Unique Identifier : AIDSLINE MED/88106474
Hirose K; Hakozaki M; Kakuchi J; Matsunaga K; Yoshikumi C; Takahashi M; Tochikura TS; Yamamoto N; Biomedical Research Laboratory, Kureha Chemical Industry Co.,; Ltd., Tokyo, Japan.
We found that PSK has an antiviral effect on human immunodeficiency virus (HIV) in vitro. One of the mechanisms of this effect is attributable to the inhibition of binding of HIV with lymphocytes. Here, we found that PSK inhibits reverse transcriptase in a non-competitive way in vitro. Such inhibition may be important
Ettensohn DB; Mayer KH; Kessimian N; Smith PS; Department of Medicine, Memorial Hospital, Pawtucket, RI 02860.
Patients with the acquired immune deficiency syndrome (AIDS) frequently develop interstitial lung disease. This is due most commonly to opportunistic infections, but malignancy and lymphocytic interstitial pneumonitis have also been associated with the syndrome. In contrast, there has been little reported about airway
J Immunol. 1988 Jan 15;140(2):602-5. Unique Identifier : AIDSLINE MED/88088879
Ljunggren K; Chiodi F; Biberfeld G; Norrby E; Jondal M; Fenyo EM; Department of Immunology, Karolinska Institute, Stockholm,; Sweden.
Sera from individuals infected with human immunodeficiency virus (HIV) and HIV-related West African viruses can mediate high-titered, virus-specific antibody-dependent cellular cytotoxicity (ADCC) in all stages of infection. No cross-reactive ADCC can be detected between HIV and HIV-related West African strains LAV-2,
Rasshofer R; Buti M; Esteban R; Jardi R; Roggendorf M; Max von Pettenkofer Institute for Hygiene and Medical; Microbiology, University of Munich, Federal Republic of Germany.
Weiss LM; Udem SA; Tanowitz H; Wittner M; Department of Pathology (Division of Parasitology and Tropical; Medicine), Albert Einstein College of Medicine, Bronx, New York; 10461.
We used immunoblotting to ascertain if toxoplasma encephalitis in disease caused by the human immunodeficiency virus (HIV) could be diagnosed by the appearance of characteristic antibodies recognizing specific Toxoplasma antigens. The profile of antibodies to Toxoplasma was examined in human serum and cerebrospinal fl
Colebunders R; Mann JM; Francis H; Bila K; Izaley L; Ilwaya M; Kakonde N; Quinn TC; Curran JW; Piot P; Project SIDA, Department of Public Health, Kinshasa, Zaire.
A recent episode or a history of herpes zoster was found in 30 (11%) of 284 patients hospitalized with human immunodeficiency virus (HIV) infection at Mama Yemo Hospital, Kinshasa, Zaire . Of 146 African patients with a history of herpes zoster who were referred to us by physicians
Qazi QH; Sheikh TM; Fikrig S; Menikoff H; Department of Pediatrics, State University of New York Health; Science Center, Brooklyn.
Thirty children perinatally exposed to human immunodeficiency virus (HIV) infection and 30 healthy control subjects matched for age, sex, and race were evaluated for growth, head size, craniofacial dysmorphism, dermatoglyphics, and other physical features. Thirteen patients met the criteria for group IV (constitutiona
JAMA. 1988 Jan 22-29;259(4):567-8. Unique Identifier : AIDSLINE MED/88091268
Drabick JJ; Egan JE; Brown SL; Vick RG; Sandman BM; Neafie RC; Infectious Disease Service, Walter Reed Army Medical Center,; Washington, DC 20307-5001.
Dicroceliasis is an unusual zoonotic trematode infection caused by the lancet liver fluke, Dicrocoelium dendriticum. Grazing herbivores (usually sheep or cattle) are the definitive hosts. The life cycle proceeds through two intermediate hosts: the land snail and the field ant. Human infection is acquired by consuming
Marx PA; Munn RJ; Joy KI; California Primate Research Center, Department of Medical; Pathology, University of California, Davis.
Electron microscopy of human immunodeficiency virus (HIV) has provided evidence for a virion model which when sectioned, consists of a circular envelope surrounding an inner conical core. When sections are perpendicular to the core axis, the envelope is still circular, but the tapered core appears as a dot near the ce
Med J Aust. 1988 Jan 18;148(2):82-5. Unique Identifier : AIDSLINE MED/88094005
Beard TC; Menzies Centre for Population Health Research, Clinical School,; University of Tasmania, Hobart.
There is an assumption that legislation against unhealthy behaviour would be unethical, or at best unenforceable and counterproductive. However, the ethics of coercion depend on the manner in which such coercion is introduced, the essential precondition being wide, favourable community consensus. Two recent Australian
N Engl J Med. 1988 Jan 28;318(4):197-203. Unique Identifier : AIDSLINE MED/88094591
Quinn TC; Glasser D; Cannon RO; Matuszak DL; Dunning RW; Kline RL; Campbell CH; Israel E; Fauci AS; Hook EW 3d; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, Bethesda, Md.
To assess the prevalence and associated risk factors for human immunodeficiency virus (HIV) infection in patients attending inner-city clinics for sexually transmitted diseases in Baltimore, we screened 4028 patients anonymously, of whom 209 (5.2 percent) were seropositive for HIV. HIV-seropositivity rates were higher
N Engl J Med. 1988 Feb 4;318(5):276-9. Unique Identifier : AIDSLINE MED/88094614
Nzilambi N; De Cock KM; Forthal DN; Francis H; Ryder RW; Malebe I; Getchell J; Laga M; Piot P; McCormick JB; Department of Medicine, Mama Yemo Hospital, Kinshasa, Zaire.
In 1985 we tested 659 human serum samples, collected in the remote Equateur province of Zaire in 1976, for antibody to human immunodeficiency virus (HIV). Five (0.8 percent) were positive, and HIV was isolated from one of these. Follow-up investigations in 1985 revealed that three
Ceroni M; Minoli L; Di Perri G; Senaldi G; Marone P; Achilli G; Mondelli M; Camana C; Clinica Neurologica, Universita di Pavia, IRCCS Fondazione C.; Mondino, Italy.
Recent evidence would suggest that HTLV-III may be neurotropic. We have found oligoclonal IgG bands by isoelectric focusing in the CSF of a homosexual man with AIDS and encephalitis. Subsequent analysis revealed that such bands contained anti-HTLV-III activity, suggesting that neurologic symptoms in AIDS patients may
vanSonnenberg E; Casola G; Maysey M; Department of Radiology, University of California San Diego; Medical Center 92103.
Current heightened awareness and concern about accidental needle puncture prompted design of a device to reduce this risk. Holes are made in the top of a prepurchased film cannister; these allow placement of all sharp objects used for angiographic and interventional radiology procedures. This protective cannister is r
Olsen WL; Jeffrey RB Jr; Tolentino CS; Department of Radiology, University of California, San Francisco.
A method of arterial puncture that makes use of a closed system was developed to reduce the likelihood of contact with blood of patients with acquired immunodeficiency syndrome (AIDS). The system includes a plastic Tuohy-Borst side-arm adapter and connecting tubing that are attached to the arterial needle. When the ar
Heller RM; Horev G; Kirchner SG; Schaffner W; Department of Radiology and Radiological Sciences, Vanderbilt; University, School of Medicine, Nashville, TN 37232.
The epidemic of the acquired immunodeficiency syndrome (AIDS) has affected all geographic regions of the United States . Indeed, it is likely that a majority of U.S. hospitals have cared for patients who are infected with the human immunodeficiency virus (HIV), the virus that causes AID
Science. 1988 Jan 1;239(4835):68-71. Unique Identifier : AIDSLINE MED/88099485
Weiss SH; Goedert JJ; Gartner S; Popovic M; Waters D; Markham P; di Marzo Veronese F; Gail MH; Barkley WE; Gibbons J; et al; Department of Preventive Medicine, New Jersey Medical School,; Newark 07103.
In a prospective cohort study of 265 laboratory and affiliated workers, one individual with no recognized risk factors for human immunodeficiency virus type 1 (HIV-1) infection was HIV-1 seropositive at the time of entry into the study. Molecular analyses of two HIV-1 isolates derived in two independent laboratories f
Science. 1988 Jan 8;239(4836):193-7. Unique Identifier : AIDSLINE MED/88099498
Castro KG; Lieb S; Jaffe HW; Narkunas JP; Calisher CH; Bush TJ; Witte JJ; AIDS Program, Centers for Disease Control, Atlanta, GA 30333.
The high cumulative incidence of AIDS and the large percentage of AIDS patients with no identified risks in Belle Glade, Florida, were evaluated through case interviews and neighborhood-based seroepidemiologic studies. It was found that of 93 AIDS patients reported between July 1982 and 1 August 1987, 34 could be dire
Science. 1988 Jan 15;239(4837):295-7. Unique Identifier : AIDSLINE MED/88099513
Ou CY; Kwok S; Mitchell SW; Mack DH; Sninsky JJ; Krebs JW; Feorino P; Warfield D; Schochetman G; Center for Infectious Diseases, Centers for Disease Control,; Atlanta, GA 30333.
By means of a selective DNA amplification technique called polymerase chain reaction, proviral sequences of the human immunodeficiency virus (HIV-1) were identified directly in DNA isolated from peripheral blood mononuclear cells (PBMCs) of persons seropositive but not in DNA isolated from PBMCs of persons seronegativ
Bayne D; Wise GJ; Division of Urology, Maimonides Medical Center, Brooklyn, New; York.
Penile and/or genital involvement may be an early manifestation of AIDS-related Kaposi sarcoma. Diagnosis may be suggested by history, and epidemiologic and sociologic data. Precise diagnosis can be documented by the urologist by early recognition and biopsy of genital lesions. Early awareness and treatment may contro
Dewhurst S; Sakai K; Zhang XH; Wasiak A; Volsky DJ; Molecular Virology Laboratory, St. Lukes/Roosevelt Hospital; Center, New York, New York.
Human malignant glioma cells were cotransfected with an infectious molecular clone of the human immunodeficiency virus (HIV) and a selectable drug resistance gene (neo). HIV/neo-positive cell clones were maintained in continuous culture for over 5 months and showed the following characteristics: (i) expression of HIV
Rousseau E; Russo P; Lapointe N; O'Regan S; Department of Pediatrics, Hopital Sainte-Justine, Montreal,; Quebec.
A low incidence of renal disease was noted in a retrospective analysis of pediatric patients with acquired immunodeficiency syndrome. Episodes of acute renal failure were attributable to dehydration or nephrotoxicity. One patient, however, had nephrosis with focal glomerular sclerosis. Focal sclerosis involving 10% to
Am J Med. 1988 Jan;84(1):94-100. Unique Identifier : AIDSLINE MED/88103628
Leport C; Raffi F; Matheron S; Katlama C; Regnier B; Saimot AG; Marche C; Vedrenne C; Vilde JL; Hopital Claude Bernard, Universite Paris VII, France.
Thirty-five patients with the acquired immunodeficiency syndrome (AIDS) and central nervous system toxoplasmosis, seen over a 30-month period, were treated with the combination pyrimethamine/sulfadiazine. All patients had clinical and computed tomographic scan findings consistent with active neurotoxoplasmosis. Mean d
Am J Public Health. 1988 Jan;78(1):55-7. Unique Identifier : AIDSLINE MED/88104333
DiClemente RJ; Boyer CB; Morales ES; Department of Epidemiology and International Health, School of; Medicine, University of California, San Francisco 94143.
White adolescents in San Francisco high schools were more knowledgeable than Black adolescents about the cause, transmission, and prevention of AIDS (acquired immunodeficiency syndrome), and Black adolescents were more knowledgeable than their Latino peers. Black and Latino adolescents were approximately twice as like
Am J Public Health. 1988 Jan;78(1):66-7. Unique Identifier : AIDSLINE MED/88104337
Landrum S; Beck-Sague' C; Kraus S; Technical Information Services, Centers for Disease Control,; Atlanta, GA 30333.
Early syphilis cases attributable to homosexual transmission declined in DeKalb County, Georgia , from 191 in 1981 to 97 in 1985. This decline occurred only among White men with same sex partners (SSP); early syphilis among Black men with same sex partners has risen. This pattern i
Am Surg. 1988 Jan;54(1):4-9. Unique Identifier : AIDSLINE MED/88104932
Ferguson CM; Department of Surgery, Emory University School of Medicine,; Atlanta, Georgia.
To assess the role of the general surgeon in the care of patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC) the hospital records of all patients with AIDS or ARC who underwent a major operation at the General Surgical Service of Crawford W. Long Memorial Hospital were reviewed. Of 7
Ann Intern Med. 1988 Jan;108(1):42-5. Unique Identifier : AIDSLINE MED/88105015
Bottles K; McPhaul LW; Volberding P; Department of Anatomic Pathology, San Francisco General Hospital,; California.
One hundred twenty-one fine-needle aspiration biopsies of lymph nodes were done on 113 men followed in the AIDS (acquired immunodeficiency syndrome) Outpatient Clinic of the San Francisco General Hospital. The cytologic diagnoses on these 121 biopsies included 60 (50%) hyperplasias, 24 (20%) non-Hodgkin lymphomas, 21
Ann Intern Med. 1988 Jan;108(1):49-51. Unique Identifier : AIDSLINE MED/88105017
Potasman I; Resnick L; Luft BJ; Remington JS; Research Institute, Palo Alto Medical Foundation, California.
We attempted to determine whether patients with the acquired immunodeficiency syndrome (AIDS) and toxoplasmic encephalitis produce Toxoplasma antibodies in the central nervous system, and whether these antibodies would be useful for diagnosing toxoplasmic encephalitis. Thirty-seven patients with AIDS and toxoplasmic e
Ann Intern Med. 1988 Jan;108(1):51-4. Unique Identifier : AIDSLINE MED/88105018
Solomon RE; Kaslow RA; Phair JP; Lyter D; Visscher B; Lyman D; VanRaden MT; Gerin J; National Institute of Allergy and Infectious Diseases, Bethesda,; Maryland.
The prevalence of hepatitis delta virus antibodies was determined in four cohorts of homosexual or bisexual men positive for hepatitis B surface antigen who were evaluated between April 1984 and April 1985. Antibodies to hepatitis delta virus were found in 16 of 106 men in Los Angeles (15.1%; 95% confidence interval [
Baumann MA; Pacheco J; Paul CC; Sorg T; Hillman N; Department of Medicine, Wright State University School of; Medicine, Dayton, Ohio.
Pancytopenia is a well-recognized manifestation of clinical illness related to human immunodeficiency virus infection. The mechanism of this has been debated, but has been thought to relate either to a nonspecific marrow suppressive effect of opportunistic infections, or to direct involvement of bone marrow hematopoie
Morgello S; Block GA; Price RW; Petito CK; Department of Pathology (Neuropathology), New York Hospital, NY; 10021.
Two patients with varicella-zoster virus leukoencephalitis and acquired immunodeficiency syndrome are described. Neither patient had cutaneous or disseminated varicella-zoster virus infection within the last six months of life. Demyelinated lesions resembling those of progressive multifocal leukoencephalopathy were se
Cuadrado LM; Guerrero A; Garcia Asenjo JA; Martin F; Palau E; Garcia Urra D; Department of Internal Medicine, Hospital Clinico de San Carlos,; Madrid.
We describe two patients with isolated cerebral mucormycosis and acquired immunodeficiency syndrome (AIDS). Their clinical course was rapid and fatal; early diagnosis and treatment with amphotericin B did not prevent a fatal outcome in both cases. Isolated cerebral mucormycosis has not (to our knowledge) been reported
N Engl J Med. 1988 Jan 14;318(2):86-90. Unique Identifier : AIDSLINE MED/88094569
Klein RS; Phelan JA; Freeman K; Schable C; Friedland GH; Trieger N; Steigbigel NH; Department of Medicine, Montefiore Medical Center, Bronx, NY; 10467.
We studied 1309 dental professionals (1132 dentists, 131 hygienists, and 46 assistants) without behavioral risk factors for the acquired immunodeficiency syndrome (AIDS) to determine their occupational risk for infection with human immunodeficiency virus (HIV). Subjects completed questionnaires on behavior; type, dura
Resnick L; Berger JR; Shapshak P; Tourtellotte WW; Department of Dermatology, Mount Sinai Medical Center, Miami; Beach, FL 33140.
CNS dysfunction occurs frequently in patients with HIV infection. To better define the role of HIV in the pathogenesis of neurologic dysfunction, HIV isolation and antibody studies were investigated from the CSF in 52 seropositive patients, 29 with and 23 without neurologic signs and symptoms, in various stages of dis
Science. 1988 Jan 8;239(4836):184-7. Unique Identifier : AIDSLINE MED/88099495
Felber BK; Pavlakis GN; National Cancer Institute, Frederick Cancer Research Facility,; Bionetics Research, Inc., MD 21701.
A bioassay that is based on trans-activation has been developed for the detection and quantitation of the human immunodeficiency virus type 1 (HIV-1). Indicator cell lines were constructed that contain the HIV-1 long terminal repeat ligated to the chloramphenicol acetyltransferase (CAT) gene. Infection of these cells
Am J Public Health. 1988 Jan;78(1):68-71. Unique Identifier : AIDSLINE MED/88104338
McCusker J; Stoddard AM; Mayer KH; Cowan DN; Groopman JE; Division of Public Health, University of Massachusetts, Amherst; 01003.
Social and behavioral factors associated with human immunodeficiency virus (HIV) infection were analyzed using cross-sectional data from homosexual and bisexual male clients of a Boston community health center. Partners from California, and a previous period of greater sexual activity (a high period), were independent
Kruskall MS; Umlas J; Department of Pathology, Beth Israel Hospital, Boston, Mass.
The devastating consequences of transfusion-associated acquired immunodeficiency syndrome have led some patients and physicians to propose recipient-orchestrated (directed) donations as a method of improving the safety of blood transfusions. This method is not safer than volunteer blood donation and introduces several
Four HIV-1 positive patients with characteristic symptoms of this infection experienced amelioration or resolution of symptoms after 2 months of hyperimmunization with inactivated (Salk) poliomyelitis vaccine. The patient who was initially the most symptomatic exhibited a marked improvement in T4/T8 ratio at the sixth
Amadori A; Faulkner-Valle GP; De Rossi A; Zanovello P; Collavo D; Chieco-Bianchi L; Institute of Oncology, University of Padova, Italy.
In order to assess whether the human retrovirus HIV, like other animal retroviruses, is endowed with intrinsic immunosuppressive activity, we studied the effects of noninfectious, uv-irradiated virus on in vitro lymphocyte function. uvHIV preparations inhibited T-cell proliferation to mitogens and alloantigens, as wel
Smith RL; el-Sadr WM; Lewis ML; Pulmonary Section, New York Veterans Administration Medical; Center, New York 10010.
We correlated bronchoalveolar lavage (BAL) cell populations with clinical course and outcome in 19 patients with Pneumocystis carinii pneumonia and acquired immunodeficiency syndrome. Twelve patients demonstrated an elevated (greater than or equal to 5 percent) BAL combined neutrophil and eosinophil count, which corre
Unger PD; Rosenblum M; Krown SE; Department of Pathology, Memorial Sloan-Kettering Cancer Center,; New York, New York 10021.
A case of disseminated pneumocystosis occurring in a patient with the acquired immunodeficiency syndrome is described. Postmortem examination of this patient, who had three episodes of Pneumocystis carinii pneumonia during his 3-year clinical course, revealed clinically unsuspected infiltration of lymph nodes, spleen,
Terwilliger E; Burghoff R; Sia R; Sodroski J; Haseltine W; Rosen C; Dana-Farber Cancer Institute, Boston, Massachusetts 02115.
A mutation that alters the initiation codon of the art gene of the human immunodeficiency virus renders the virus replication defective. The replication defect of this mutation can be complemented in trans by the art gene product. These findings indicate that the art protein is essential for replication and, as such,
Chandra P; Delaney MD; Tuazon CU; Department of Medicine, George Washington University Medical; Center Hospital, Washington, D.C. 20037.
Fifty bronchial washing specimens from 36 patients with acquired immune deficiency syndrome (AIDS) were retrospectively reviewed to assess the sensitivity of the various special stains used to diagnose Pneumocystis carinii. In 76% of the cases, the Diff-Quik stain was positive; it was the easiest and most rapid of the
Am J Med. 1988 Jan;84(1):82-8. Unique Identifier : AIDSLINE MED/88103626
Kopelman RG; Zolla-Pazner S; Department of Medicine, Columbia Presbyterian Medical Center, New; York, New York.
Patients infected with human immunodeficiency virus have a variety of presentations including fevers, lymphadenopathy, rash, renal dysfunction, and neurologic and hematologic disorders. Many of these features are also seen in patients with systemic lupus erythematosus (SLE). Herein are described five patients ultimate
Ann Thorac Surg. 1988 Jan;45(1):21-3. Unique Identifier : AIDSLINE MED/88105686
Fleisher AG; McElvaney G; Lawson L; Gerein AN; Grant D; Tyers GF; Division of Cardiovascular and Thoracic Surgery, St. Paul's; Hospital, University of British Columbia, Vancouver, Canada.
Spontaneous pneumothorax has been reported with increasing frequency in patients with acquired immunodeficiency syndrome and Pneumocystis carinii pneumonia. In the past year, we treated 4 patients with spontaneous pneumothorax. All of them were treated with closed tube thoracostomy, and 1 patient with bilateral apical
Wachter RM; Cooke M; Hopewell PC; Luce JM; Medical Services, San Francisco General Hospital Medical Center,; CA 94110.
We recently surveyed the medical house staff at the University of California, San Francisco, and found that residents had a good understanding of the poor prognosis of patients with the acquired immunodeficiency syndrome (AIDS) and Pneumocystis carinii pneumonia who require intensive care for respiratory failure, and
Lippman SM; Volk JR; Spier CM; Grogan TM; Section of Hematology/Oncology, Arizona Cancer Center.
Initial biopsy specimens from two patients with lymphadenopathy and human immunodeficiency virus antibody-positive serum presented considerable difficulty in making specific histologic and immunologic diagnoses, although subsequent biopsy specimens revealed clear progression to acquired immunodeficiency syndrome (AIDS
Int J Cancer. 1988 Jan 15;41(1):115-22. Unique Identifier : AIDSLINE MED/88085573
Ohta Y; Masuda T; Tsujimoto H; Ishikawa K; Kodama T; Morikawa S; Nakai M; Honjo S; Hayami M; Department of Animal Pathology, University of Tokyo, Japan.
Sixteen isolates of simian retrovirus closely related to human immunodeficiency virus (HIV) were obtained from healthy African green monkeys (AGM) (Cercopithecus aethiops). The first isolate was obtained from a monkey seropositive for HIV, and the others were isolated from monkeys harboring antibodies to the first iso
We molecularly cloned the gag and env genes of the human immunodeficiency virus (HIV) and expressed fragments of these genes in Escherichia coli. Using the recombinant core and envelope proteins, we developed two competitive immunoassays (CIAs). Samples that recognized either the envelope or core proteins were conside
Roy S; Wainberg MA; Lady Davis Institute for Medical Research, Sir Mortimer B.; Davis-Jewish General Hospital, Montreal, Quebec, Canada.
This review describes current understanding of the role of cells of the mononuclear phagocyte system in the development of acquired immunodeficiency syndrome (AIDS). Monocyte-macrophage like cells have been shown to harbor human immunodeficiency virus type 1 (HIV-I) infection in both peripheral blood and bone marrow a
JAMA. 1988 Jan 8;259(2):229-32. Unique Identifier : AIDSLINE MED/88091211
Henry K; Maki M; Crossley K; Department of Medicine, St Paul-Ramsey Medical Center, MN 55101.
We retrospectively studied the clinical use of human immunodeficiency virus (HIV) antibody serology at one 450-bed medical center and affiliated clinics from April 1985 through August 1986. No restrictions were placed on the use of HIV antibody serology during that time, although it was recommended that consent be obt
JAMA. 1988 Jan 22-29;259(4):545-9. Unique Identifier : AIDSLINE MED/88091263
Greenberg AE; Nguyen-Dinh P; Mann JM; Kabote N; Colebunders RL; Francis H; Quinn TC; Baudoux P; Lyamba B; Davachi F; et al; Malaria Branch, Centers for Disease Control, Atlanta, GA 30333.
Since Plasmodium falciparum malaria is a frequent cause of anemia among African children, and blood transfusions, unscreened for human immunodeficiency virus (HIV) antibody, are used frequently in the treatment of children with severe malaria, the relationships between malaria, transfusions, and HIV seropositivity wer
Nature. 1988 Jan 21;331(6153):280-3. Unique Identifier : AIDSLINE MED/88094738
Jacks T; Power MD; Masiarz FR; Luciw PA; Barr PJ; Varmus HE; Department of Biochemistry, University of California Medical; Center, San Francisco 94143.
Based on precedents from other retroviruses, the precursor of the human immunodeficiency virus (HIV-1) reverse transcriptase is predicted to be a polyprotein with a relative molecular mass (Mr) of 160,000 (160K) encoded by both the viral pol gene and the upstream gag gene. These two genes lie in different translationa
Federle MP; Department of Radiology, San Francisco General Hospital, CA; 94110.
Many other symptom complexes could be discussed that affect virtually every organ system of patients with AIDS or ARC. While important and interesting, these are less likely to come to the attention of the radiologist for assistance in diagnosis and management. The scope of this review has also precluded discussion of
Science. 1988 Jan 22;239(4838):375-80. Unique Identifier : AIDSLINE MED/88099521
Brandt AM; Department of Social Medicine, and Health Policy, Harvard Medical; School, Boston, MA 02115.
This article presents an overview of the history of medical and public health responses to syphilis in the 20th-century United States and briefly evaluates the relevance and significance of these approaches for the AIDS epidemic. The parallels are numerous: they relate to science, publ
Am Fam Physician. 1988 Jan;37(1):213-9. Unique Identifier : AIDSLINE MED/88103210
Loschen DJ; York Medical Clinic, Nebraska.
The magnitude of the AIDS epidemic is exceeding the predictions of a short time ago. Since AIDS patients are being encountered more frequently in family practice, the possibility of accidental exposure to HIV has become a source of concern. By exercising specific precautions and by minimizing misconceptions about the
Taylor RN; Przybyszewski VA; Division of Assessment and Management Consultation Training,; Centers for Disease Control, Atlanta, Georgia 30333.
During 1985 and 1986, the Centers for Disease Control conducted eight surveys to evaluate laboratory performance in testing for antibody to human immunodeficiency virus (HIV). (Other names for this virus include human T-lymphotropic virus type III and lymphadenopathy associated virus.) The first survey was conducted w
Am J Gastroenterol. 1988 Jan;83(1):1-7. Unique Identifier : AIDSLINE MED/88103452
Lebovics E; Dworkin BM; Heier SK; Rosenthal WS; Sarah C. Upham Division of Gastroenterology, New York Medical; College, Valhalla.
Liver abnormalities are common in patients with acquired immune deficiency syndrome. These relate to 1) coincident exposure to hepatotropic viruses, 2) complications, either infectious, neoplastic, or iatrogenic, of the immunosuppressed state, or 3) nonspecific changes associated with chronic debilitating illness. We
Am J Gastroenterol. 1988 Jan;83(1):20-1. Unique Identifier : AIDSLINE MED/88103458
Deschamps MM; Pape JW; Verdier RI; DeHovitz J; Thomas F; Johnson WD Jr; Haitian Study Group on Kaposi's Sarcoma and Opportunistic; Infections (GHESKIO), Port-Au-Prince, Haiti.
We conducted a randomized prospective study to compare the efficacy of oral miconazole and ketoconazole in the treatment of candida esophagitis in acquired immune deficiency syndrome (AIDS) patients in Haiti . Twelve AIDS patients with endoscopic and microscopic diagnoses of candida
Am J Med. 1988 Jan;84(1):162-4. Unique Identifier : AIDSLINE MED/88103602
Mascola L; Lieb L; Chiu J; Fannin SL; Linnan MJ; Los Angeles County Department of Health Services, California.
Between January 1985 and March 1986, five cases of listeriosis were reported in Los Angeles County in patients with the acquired immunodeficiency syndrome (AIDS). All patients were homosexual men with no other risk factors for AIDS. Two patients had sepsis only, two patients had sepsis and meningitis, and one patient
Am J Med Sci. 1988 Jan;295(1):52-4. Unique Identifier : AIDSLINE MED/88103665
Hewitt WD; Farrar WE; Medical University of South Carolina, Department of Medicine,; Charleston 29425.
Ecthyma is an ulcerated form of impetigo due to Streptococcus pyogenes, seen primarily in children with poor hygiene. The authors report a homosexual man with acquired immunodeficiency syndrome (AIDS) who developed severe ecthyma and bacteremia caused by S. pyogenes. Opsonizing antibody to the M protein of S. pyogenes
Am J Med Sci. 1988 Jan;295(1):55-9. Unique Identifier : AIDSLINE MED/88103666
Holder CD; Halkias D; University of South Florida College of Medicine, Division of; Infectious and Tropical Diseases, Tampa 33612.
The acquired immunodeficiency syndrome (AIDS) is manifested by severe immunologic (predominantly T-lymphocyte) abnormalities and opportunistic infections. Central nervous system (CNS) infections are frequent. Pathogens causing CNS infections in AIDS patients include parasites, fungi, and viruses and are similar to tho
Am J Public Health. 1988 Jan;78(1):52-4. Unique Identifier : AIDSLINE MED/88104332
Feldblum PJ; Fortney JA; Family Health International, Division of Reproductive; Epidemiology and Sexually Transmitted Diseases, Research Triangle; Park Branch, Durham, NC 27709.
Ann Intern Med. 1988 Jan;108(1):46-8. Unique Identifier : AIDSLINE MED/88105016
Bowen PA 2d; Lobel SA; Caruana RJ; Leffell MS; House MA; Rissing JP; Humphries AL; Department of Medicine, Medical College of Georgia, Augusta.
The human immunodeficiency virus (HIV) was transmitted to a patient who received a cadaveric renal transplant from a donor who had received massive blood component replacement. A negative HIV antibody test was obtained on serum drawn immediately after transfusion. After transplantation, pretransfusion sera and sera ob
Eeftinck Schattenkerk JK; Danner SA; Lange JM; Paul DA; van Boxtel CJ; Miedema F; Schellekens PT; Goudsmit J; Department of Internal Medicine, University of Amsterdam.
Ten homosexual men with the acquired immunodeficiency syndrome were included in a serologic follow-up study (duration, 40 weeks) of human immunodeficiency virus (HIV) antigenemia. Five of these men were treated with the reverse transcriptase inhibitor, suramin, for a period of 19 to 37 weeks. In contrast with reported
Poon M; Cronin DC 2d; Wormser GP; Bottone EJ; Department of Microbiology, Mount Sinai Medical Center, New York,; NY 10029-6574.
Cryptococcus neoformans strains from 26 individual patients with acquired immunodeficiency syndrome (AIDS) and three isolates from patients without AIDS were tested for their susceptibility to amphotericin B, flucytosine, ketoconazole, and miconazole nitrate. Ninety percent of the C neoformans isolates from patients w
Br Med J (Clin Res Ed). 1987 Oct 31;295(6606):1118-20. Unique Identifier : AIDSLINE MED/88078991
Lehmann P; Hausser D; Somaini B; Gutzwiller F; University Institute of Social and Preventive Medicine, Lausanne,; Switzerland.
The campaign against the spread of the acquired immune deficiency syndrome (AIDS) in Switzerland includes a nationwide educational programme. A booklet about AIDS was mailed to every Swiss household in March 1986, and in 1987 there has been a mass media campaign promoting the
Br Med J (Clin Res Ed). 1987 Dec 5;295(6611):1445-6. Unique Identifier : AIDSLINE MED/88079157
Skeoch CH; Coutts NA; Goel KM; Follett EA; Royal Hospital for Sick Children, Yorkhill, Glasgow.
A 3 1/2 year old girl presented with failure to thrive and a five month history of diarrhoea and recurrent cough. The results of sweat sodium tests suggested a diagnosis of cystic fibrosis; but atypical organisms were found (Haemophilus influenzae, Candida albicans, but no Staphylococcus aureus), she failed to respond
The surveillance of cases of the acquired immune deficiency syndrome (AIDS) in the United Kingdom is described and a preliminary analysis made of the 1012 cases that were reported to the end of August 1987. Homosexuals were the largest risk group. For the first time it is possible to p
Cancer Detect Prev Suppl. 1987;1:553-6. Unique Identifier : AIDSLINE MED/88080272
Baroni CD; Pezzella F; Department of Biopathology, University, La Sapienza, Roma, Italy.
Lymph nodes of patients with lymphadenopathy syndrome (LAS) are characterized by two main histological patterns: hyperplastic reactive (H) and regressive (R). In both conditions, the paracortex (PC) is markedly activated with presence of selectively Ia-1+ high endothelial venules. Using a monoclonal antibody for p24,
Dichtelmuller H; Stephan W; Prince AM; Gurtler L; Deinhardt F; Biotest Pharma GmbH, Department of Research, Frankfurt.
The inactivation of HIV in human plasma and plasma derivatives by combined treatment with beta-propiolactone and UV-irradiation was investigated. beta-propiolactone inactivated greater than or equal to 3.5 log10 and UV greater than or equal to 2.8 log10 HIV in plasma and beta-propiolactone greater than or equal to 3.5
Ikuta K; Ueda S; Uchida T; Okada Y; Kato S; Department of Pathology, Osaka University.
Liposomes containing fragment A of diphtheria toxin killed human immunodeficiency virus (HIV)-producing MOLT-4 or TALL-1 cells, and HTLV-I-carrying MT-4 cells infected with HIV, but did not kill these cells when they were not infected with HIV. This killing was not affected by the presence of HIV antibodies. These res
Nakashima H; Yoshida O; Tochikura TS; Yoshida T; Mimura T; Kido Y; Motoki Y; Kaneko Y; Uryu T; Yamamoto N; Department of Virology and Parasitology, Yamaguchi University; School of Medicine, Ube.
The inhibitory effects of several polysaccharides, dextran, xylofuranan, and ribofuranan, and their sulfated counterparts on the infectivity and replication of human immunodeficiency virus (HIV) were examined by using an HTLV-I-carrying cell line, MT-4, in vitro. Dextran sulfate (Mw 34 X 10(3], xylofuranan sulfate, an
J Immunol. 1988 Jan 1;140(1):120-4. Unique Identifier : AIDSLINE MED/88088793
Wong GH; Krowka JF; Stites DP; Goeddel DV; Department of Molecular Biology, Genentech, Inc., South San; Francisco, CA 94080.
Treatment of cells with tumor necrosis factor-alpha and interferon-gamma greatly reduces their susceptibility to infection with human immunodeficiency virus and suppresses the production of human immunodeficiency virus (HIV) mRNA, core protein p24, and infectious HIV. The combination treatment is cytotoxic for HIV-inf
Becker J; Schuppan D; Reichart P; Department of Oral Surgery, Faculty of Dentistry, Free University; of Berlin.
Twelve oral AIDS-associated Kaposi sarcomas (KS) were studied for the distribution of extracellular matrix components using indirect immunofluorescence. Staining for basement membrane (BM) components revealed two distinct patterns of distribution: a delicate and partly fragmented lining of BMs around sinusoid-like vas
Ann Intern Med. 1988 Jan;108(1):36-41. Unique Identifier : AIDSLINE MED/88105014
Murphy PM; Lane HC; Gallin JI; Fauci AS; Laboratory of Clinical Investigation, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland.
STUDY OBJECTIVE: To compare the infectious complications that occurred during trials of immunomodulatory agents in patients with the acquired immunodeficiency syndrome (AIDS). DESIGN: A survey of two cohorts of patients with AIDS who participated in nonrandomized, unblinded, non-placebo-controlled investigations of th
Cancer Detect Prev Suppl. 1987;1:611-8. Unique Identifier : AIDSLINE MED/88080281
Tsang P; Bekesi JG; Department of Neoplastic Diseases, Mount Sinai School of Medicine; and Hospital, New York, NY 10029.
Applying flow cytometric analysis and a panel of monoclonal antibodies that define functional subsets and stages of lymphocyte differentiation, we found both inducer and suppressor regulating subsets of helper T cells to be depressed with concurrent increase in the functionally active effector suppressor T cells in pr
Pomerantz RJ; Schooley RT; Infectious Disease Unit, Massachusetts General Hospital, Boston.
Although therapy is currently available for many of the infections and neoplastic complications of AIDS, there is no effective therapy for the underlying immunodeficiency state. The authors review various attempts at treatment to date, and conclude that a major decrease in HIV-associated morbidity will require a combi
Maggi E; Macchia D; Parronchi P; Mazzetti M; Ravina A; Milo D; Romagnani S; Department of Clinical Immunology, University of Florence, Italy.
Purified T lymphocytes (E rosetting cells) isolated from peripheral blood (PB) of four patients with acquired immune deficiency syndrome (AIDS) were cloned under culture conditions (phytohemagglutinin plus interleukin 2) which allow clonal expansion of most T lymphocytes. A total number of 101 T cell clones (37 CD4+ a
The theory predicts that inbred strains of mice are susceptible to tumor viruses that have escaped immune recognition. The theory implies routine evolutionary extinction of asexual species and that existing parthenogenetic species would have to have evolved recently from sexually reproducing precursors. This could be
Joshi VV; Gadol C; Connor E; Oleske JM; Mendelson J; Marin-Garcia J; Department of Pathology, Children's Hospital of New Jersey,; Newark 07107.
Clinicopathologic features with special reference to the heart are presented in five fatal cases of acquired immunodeficiency syndrome (AIDS) in children. Three children showed clinical evidence of cardiovascular compromise or congestive heart failure. Autopsy was performed in all cases. The enlarged heart showed bive
Perlstein LM; Ake JM; Dept. of Nursing, New York University Medical Center, NY 10016.
Four out of ten acquired immune deficiency syndrome (AIDS) patients develop neurologic complications. Because of the complex nervous system dysfunction experienced by these patients, neuroscience nurses face an extraordinary challenge. To provide care for patients with neurological complications of AIDS, the neuroscie
Ake JM; Perlstein LM; Department of Nursing, New York University Medical Center, NY; 10016.
Diseases of the central nervous system (CNS) have been recognized as an integral part of acquired immune deficiency syndrome (AIDS) since the beginning of the epidemic. This large patient population has both major physical problems and severe cognitive disabilities. Professional neuroscience nurses who are knowledgeab
Drake JH; Parmley RT; Britton HA; Department of Pediatrics, University of Texas Health Science; Center, San Antonio 78284-7810.
The presence of human immunodeficiency virus (HIV) antibody in hemophilia patients was correlated with the loss of existing antibody to hepatitis B surface antigen (HBsAb) or the inability to develop an antibody to hepatitis B after receiving commercially available hepatitis B vaccine. Of the 137 patients studied 66 w
Seven hundred and forty subjects who, between 1980 and 1985, had received intravenous or intramuscular injections of immunoglobulins (Ig) prepared by Cohn fractionation of plasma pools from more than 2000 donors were investigated for anti-HIV antibodies. Anti-HIV antibodies were detected in only one subject, a female
Regueiro JR; Lopez-Botet M; De Landazuri MO; Alcami J; Corell A; Martin-Villa JM; Vicario JL; Arnaiz-Villena A; Hospital Primero de Octubre, Madrid, Spain.
A polyclonal T-cell receptor complex (TCR) expression defect (as detected with monoclonal antibody WT31) has been found in two children belonging to an otherwise healthy Spanish family. One of the sibs (V, who had been vaccinated with attenuated poliomyelitis virus) showed clinical signs of immunodeficiency with an au
T-cell subsets, antibodies (Ab) against human immunodeficiency virus (HIV) and clinical status were evaluated during a 31 (24-35) month follow-up study of homosexual men. The study group included 50 homosexual men, with many sexual partners, who by 1982-83 were without symptoms and had a prevalence of HIV Ab of 38%. A
Acheson JF; Shah SM; Spalton DJ; Bradbeer C; Thin RN; Medical Eye Unit, St. Thomas's Hospital, London.
We present a case of cytomegalovirus ( CMV ) retinitis in an AIDS patient who survived for 10 months after the start of his ocular problems. The retinitis responded to dihydroxy propoxy methyl guanine (DHPG) but relapsed four t
Childs Nerv Syst. 1987;3(4):255-7. Unique Identifier : AIDSLINE MED/88080199
Curless RG; Scott GB; Post MJ; Gregorios JB; Department of Neurology, University of Miami School of Medicine,; FL 33101.
Congenital central nervous system infection with cytomegalovirus ( CMV ) usually results in a nonprogressive encephalopathy. Ninety percent of patients with clinically apparent infections at birth have a permanent neurological
Cancer Detect Prev Suppl. 1987;1:493-9. Unique Identifier : AIDSLINE MED/88080263
Magasiny S; Spire B; Rey F; Barre-Sinoussi F; Chermann JC; Viral Oncology Unit, Institut Pasteur, Paris, France.
LAV/HTLV-III has been found to be the etiological cause of AIDS. This new human retrovirus has a selective tropism for T lymphocytes of the OKT4/leu 3 subset, in which it induces a cytopathic effect. We have compared Southern blot patterns of integrated proviral DNAs from different individuals at risk or not using a n
Cancer Detect Prev Suppl. 1987;1:549-52. Unique Identifier : AIDSLINE MED/88080271
Ragona G; Sirianni MC; Department of Experimental Medicine, University of Rome, La; Sapienza, Italy.
Patients affected by AIDS related-complex (ARC) showed several immunological abnormalities that could lead to a disregulation of immunosurveillance against viral latent infections. We report Epstein-Barr virus (EBV) reactivation was found in seven of eight ARC patients and in two of seven affected by persistent genera
Cancer Metastasis Rev. 1987;6(3):243-60. Unique Identifier : AIDSLINE MED/88080787
Olsen RG; Lewis MG; Lafrado LJ; Mathes LE; Haffer K; Sharpee R; Ohio State University, Department of Veterinary Pathobiology,; Columbus.
This is a review of the current knowledge of feline leukemia virus (FeLV) associated with immune depression observed in cats. It will focus on the clinical and experimental observations associated with feline retroviral infection and presence in vivo and in vitro. We will briefly describe retroviral-associated acquire
Wainberg MA; Blain N; Fitz-Gibbon L; Lady Davis Institute for Medical Research, Sir Mortimer B.; Davis-Jewish General Hospital, Montreal, Quebec, Canada.
We have assessed the ability of HIV to infect cultures of peripheral blood lymphocytes derived from different healthy donors, varying in age between 20 and 76. The results indicate that cells from all of these people can be infected, although the percentage of infected cells varied from case to case. A similar variati
Weintrub PS; Department of Pediatric Infectious Diseases, University of; California, San Francisco.
Immune globulin preparations clearly provide safe and effective passive prophylaxis in a variety of viral infections: hepatitis A, hepatitis B, primary varicella zoster, measles, rubella, and rabies. When available, specific preparations (HBIG, VZIG, RIG) should be used. The use of CMVIG remains controversial at this
EMBO J. 1987 Oct;6(10):3133-7. Unique Identifier : AIDSLINE MED/88082686
Larder B; Purifoy D; Powell K; Darby G; Department of Biochemical Virology, Wellcome Research; Laboratories, Beckenham, Kent, UK.
The causative agent of AIDS the human immunodeficiency virus (HIV) encodes as part of its pol gene a reverse transcriptase (RT) which has a key role in the replication of the virus and thus constitutes an ideal target for antiviral chemotherapy. The purified HIV RT from virus particles consists of two related polypept
Sirianni MC; Volpi A; Soddu S; Mancino R; Aiuti F; Rocchi G; Department of Allergology and Clinical Immunology, University of; Rome La Sapienza, Italy.
This study was undertaken with the aim of elucidating the mechanisms underlying the cell-mediated immunodeficiency seen in the acquired immunodeficiency syndrome (AIDS). An intrinsic functional defect in the in vitro surviving T lymphocytes from patients with AIDS has been described. This defect is reflected by profou
Bockus D; Remington F; Luu JY; Bean M; Hammar S; Department of Pathology, Virginia Mason Medical Center, Seattle,; WA 98111.
Cylindrical confronting cisternae (CCC), also known as test-tube and ring-shaped forms, are frequently present in the cytoplasm of lymphocytes and occasionally in other cells from patients with acquired immunodeficiency syndrome (AIDS). Recent data indicate that the presence of these cisternae and tubuloreticular stru
J Immunol. 1987 Dec 15;139(12):4049-54. Unique Identifier : AIDSLINE MED/88088757
Nutman TB; Delespesse G; Sarfati M; Volkman DJ; Laboratory of Parasitic Diseases, National Institutes of Health,; Bethesda, MD 20892.
In order to derive T cell clones that can produce factors that specifically regulate the IgE response, Fc epsilon receptor (Fc epsilon R)-positive T cells were isolated from two patients with hyper-IgE states (either the tropical pulmonary eosinophilia syndrome or the hyper-IgE syndrome) and transformed using the huma
J Immunol. 1987 Dec 15;139(12):4055-60. Unique Identifier : AIDSLINE MED/88088758
Sarfati M; Nutman TB; Suter U; Hofstetter H; Delespesse G; University of Montreal, Notre-Dame Hospital, Research Centre,; Quebec, Canada.
We previously described human T cell leukemia/lymphoma virus-1-transformed T cell clones expressing surface molecules binding to monoclonal antibodies against lymphocyte Fc epsilon receptor (Fc epsilon R) and releasing soluble factors binding to both IgE and to monoclonal antibody to lymphocyte Fc epsilon R. In this s
Debs RJ; Montgomery AB; Brunette EN; DeBruin M; Shanley JD; Cancer Research Institute, University of California, San; Francisco Medical Center 94143.
Cytomegalovirus ( CMV ) pneumonia causes significant morbidity and mortality in bone marrow transplant recipients and in patients with AIDS. 9-(1,3-Dihydroxy-2-propoxymethyl) guanine (ganciclovir) and phosphonoformic acid (PFA) demonstrate activity against CMV in
Daniel MD; Letvin NL; Sehgal PK; Hunsmann G; Schmidt DK; King NW; Desrosiers RC; New England Regional Primate Research Center, Harvard Medical; School, Southborough, Massachusetts 01772.
Juvenile rhesus macaques 6 to 18 months of age were experimentally infected by intravenous inoculation with the simian immunodeficiency virus (SIV), the T cell-tropic retrovirus of monkeys related to the human acquired immunodeficiency syndrome (AIDS) virus HIV. The SIV used for inoculation was grown either in normal
Saito S; Nakamura M; Ohtani K; Ichijo M; Sugamura K; Hinuma Y; Institute for Virus Research, Kyoto University, Japan.
A trans-acting factor, p40, of human T-cell leukemia virus type I profoundly potentiated the function of the enhancer from simian virus 40 but not polyomavirus and Rous sarcoma and murine sarcoma viruses. This trans-activation was seen in a limited repertoire of cells, in contrast to trans-activation of the human T-ce
Kohtz DS; Altman A; Kohtz JD; Puszkin S; Department of Pathology, Mount Sinai School of Medicine, City; University of New York, New York 10029.
The N-terminal segment of human interleukin-2 (hIL-2) appears to mediate binding of the beta hIL-2 receptor (R. Robb, C. Rusk, J. Yodoi, and W. Greene, Proc. Natl. Acad. Sci. USA 84:2002-2006, 1987). An affinity-purified antibody prepared against this peptide segment (p81) is shown here to cross-react with a homologou
JAMA. 1988 Jan 15;259(3):384-8. Unique Identifier : AIDSLINE MED/88091240
Resnick L; Herbst JS; Ablashi DV; Atherton S; Frank B; Rosen L; Horwitz SN; Department of Dermatology, Mount Sinai Medical Center, Miami; Beach, FL 33140.
To define the role of Epstein-Barr virus (EBV) in the pathogenesis of oral hairy leukoplakia, 13 human immunodeficiency virus-seropositive men with clinical and histologic evidence of oral hairy leukoplakia were enrolled in an open-label trial of orally administered acyclovir th
Balzarini J; Cooney DA; Dalal M; Kang GJ; Cupp JE; DeClercq E; Broder S; Johns DG; Clinical Oncology Program, National Cancer Institute, Bethesda,; Maryland 20892.
The antiretroviral action of 2 ,3 -dideoxycytidine (ddCyd) depends on its intracellular conversion to the 5 -triphosphate metabolite ddCTP. The effect of natural pyrimidines and pyrimidine nucleosides, as well as of a number of inhibitors of pyrimidine nucleotide synthesis (i.e., N-(phosphonacetyl)-L-aspartate, 6-azau
Takebe Y; Seiki M; Fujisawa J; Hoy P; Yokota K; Arai K; Yoshida M; Arai N; Department of Molecular Biology, DNAX Research Institute of; Molecular and Cellular Biology, Palo Alto, California 94304.
We developed a novel promoter system, designated SR alpha, which is composed of the simian virus 40 (SV40) early promoter and the R segment and part of the U5 sequence (R-U5 ) of the long terminal repeat of human T-cell leukemia virus type 1. The R-U5 sequence stimulated chloramphenicol acetyltransferase (CAT) gene e
N Engl J Med. 1988 Feb 4;318(5):301-5. Unique Identifier : AIDSLINE MED/88094618
Houff SA; Major EO; Katz DA; Kufta CV; Sever JL; Pittaluga S; Roberts JR; Gitt J; Saini N; Lux W; Infectious Diseases Branch, National Institute of Neurological; and Communicative Disorders and Stroke, Bethesda, MD 20892.
Madden DL; Mundon FK; Tzan NR; Fuccillo DA; Dalakas MC; Calabrese V; Elizan TS; Sever JL; National Institute of Neurological and Communicative Disorders; and Stroke, MD 20892.
We have studied the frequency of human retrovirus antibody (HTLV-I, II, III) in the serum and CSF of patients with MS, matched controls, and patients with optic neuritis, idiopathic and postencephalitic Parkinson s disease, neuropathies, polymyositis, ALS, and postpoliomyelitis. Except for the postpoliomyelitis sample
Fagan EA; Partridge M; Sowray JH; Williams R; King's College Hospital, London, England.
There is now an increased awareness of the risk of transmission of viral infections via blood and saliva after the publicity given to the human immunodeficiency viruses responsible for the acquired immunodeficiency syndrome. The herpesviruses have been found in blood, in blood products, and in saliva, and information
Rosenthal A; Ulrich R; Billwitz H; Frank R; Blocker H; Akademie der Wissenschaften der DDR, Zentralinstitut fur; Molekularbiologie, Berlin-Buch.
A synthetic gene for a 88 amino acid long env protein fragment of the human T-cell leukemia virus type 1 (HTLV1) has been assembled by ligation of 35 oligodesoxyribonucleotides, which were chemically synthesized by the phosphotriester segmental support method. After cloning into the pEX vector this HTLV1 env-protein f
Pediatr Med Chir. 1987 Jul-Aug;9(4):407-11. Unique Identifier : AIDSLINE MED/88096870
Pavari E; Marano E; Prete A; Paperi P; Marranci S; Mazzoni D; Clinica Pediatrica III, Universita di Firenze, Italia.
EBV infection may have a wide range of clinical consequences: it is often asymptomatic; some cases-generally adolescents-develop the classic infectious mononucleosis syndrome; in rare cases the illness takes a severe, fatal course. EBV is also implicated in some geographic areas, in Burkitt lymphoma and naso-pharynge
Hall CB; Department of Pediatrics and Medicine, University of Rochester; School of Medicine, NY.
The most frequent agents of pneumonia acquired by children in the hospital are viruses. The characteristics of these nosocomial viral agents differ appreciably from the more classical bacterial nosocomial infections. The viral agents tend to be more contagious, with normal children being as susceptible as the predispo
Klotman ME; Hamilton JD; Medical Research Service, Durham Veterans Administration Medical; Center, NC 27705.
Cytomegalovirus ( CMV ) is a common virus that asymptomatically infects the majority of the population by early adulthood. After initial infection, the virus remains in a latent state in the host and can be reactivated under a variety of conditions. In contrast to
de Blic J; McKelvie P; Le Bourgeois M; Blanche S; Benoist MR; Scheinmann P; Service de Pneumologie et d'Allergologie Infantiles, Hopital des; Enfants Malades, Paris.
The diagnostic value of 73 bronchoalveolar lavages was assessed in 67 immunocompromised children (aged 3 months to 16 years) with pulmonary infiltrates. Thirty one children had primary and 19 secondary immune deficiency, 14 acquired immunodeficiency syndrome (AIDS), and three AIDS related complex. Bronchoalveolar lava
Loning T; Henke RP; Reichart P; Becker J; Institut fur Pathologie der Universitat Hamburg, Federal; Republic of Germany.
Thirty biopsies of oral mucosal lesions and normal oral mucosa were obtained from 26 HIV-seropositive individuals and studied for virus infections with Epstein-Barr virus-specific DNA probes (EBV). In situ DNA hybridization was carried out on frozen and formalin-fixed, paraffin-embedded tissues. Specifically bound bio
Two autopsy cases of CMV colitis in AIDS are reported. Intestinal manifestations lasted 2 and 5 months in each case and included: diarrhea and abdominal colic pain. The causes of death were: disseminated CMV infection in case 1 and miliary tuberculosis in case 2
Maeda K; Yamana K; Takahashi H; Jimbow K; Department of Dermatology, Sapporo Medical College, Japan.
The phenotypic and morphological profiles of atypical cells in a case of adult T cell leukaemia/lymphoma were studied using a panel of monoclonal antibodies and electron microscopy. Retroviral sequence restriction analysis showed the presence of human T cell leukaemia/lymphoma virus type I (HTLV-I) in the skin lesion.
Niitsu Y; Urushizaki Y; Koshida Y; Terui K; Mahara K; Kohgo Y; Urushizaki I; Fourth Department of Internal Medicine, Sapporo Medical College,; Japan.
Peripheral mononuclear cells from adult T cell leukemia (ATL) patients were analyzed in comparison with other types of leukemia cells, for the expression of transforming growth factor-beta (TGF-beta) mRNA, for the presence of TGF-beta activity (colony stimulating activity for normal rat kidney fibroblasts [NRK]) in co
Cancer Surv. 1987;6(1):139-59. Unique Identifier : AIDSLINE MED/88080122
Burny A; Cleuter Y; Kettmann R; Mammerickx M; Marbaix G; Portetelle D; Van den Broeke A; Willems L; Thomas R; Faculty of Agronomy, Gembloux, Belgium.
Bovine leukaemia virus (BLV) is the aetiological agent of a chronic lymphatic leukaemia/lymphoma in cows, sheep and goats. Infection without neoplastic transformation has also been demonstrated in pigs, rhesus monkeys, chimpanzees and rabbits and observed in capybaras and water buffaloes. Structurally and functionally
Cancer Surv. 1987;6(1):55-71. Unique Identifier : AIDSLINE MED/88080125
Gardner MB; Department of Medical Pathology, University of California, Davis; 95616.
This article presents a historical perspective of the wild mouse leukaemia virus (MuLV) model system in light of the prevailing concepts in the early 1970s when this work was carried out. The epidemiology and natural history of MuLV and its associated lymphoma in wild mice were remarkably predictive of later events as
Drug Metab Dispos. 1987 Sep-Oct;15(5):595-601. Unique Identifier : AIDSLINE MED/88082080
Kelley JA; Litterst CL; Roth JS; Vistica DT; Poplack DG; Cooney DA; Nadkarni M; Balis FM; Broder S; Johns DG; Laboratory of Pharmacology and Experimental Therapeutics,; National Cancer Institute, Bethesda, MD 20892.
The pharmacokinetics and metabolism of the anti-human T-lymphotrophic virus type III/lymphadenopathy-associated virus agent 2 ,3-dideoxycytidine have been examined in BDF1 mice and rhesus monkeys, with ancillary enzyme studies carried out on tissue derived from both the latter species and also from human subjects. For
Environ Health Perspect. 1987 Nov;75:11-5. Unique Identifier : AIDSLINE MED/88082577
Waldmann TA; National Cancer Institute, Bethesda, MD 20892.
Antigen-induced activation of resting T-cells induces the synthesis of interleukin-2 ( IL-2 ), as well as the expression of specific cell surface receptors for this lymphokine. There are at least two forms of the cellular receptors for IL-2, one with a very high affinity
Hirose Y; Imaoka T; Konda S; Department of Internal Medicine, Kanazawa Medical University,; Ishikawa, Japan.
A 31-year-old woman with adult T-cell leukemia developed interstitial pneumonitis. Large abnormal cells different from those of adult T-cell leukemia appeared in the peripheral blood. Hematoxylin-eosin staining of the buffy coat of peripheral blood revealed these cells to be cytomegalic inclusion cells. Electron micro
Int J Cancer. 1987 Dec 15;40(6):741-6. Unique Identifier : AIDSLINE MED/88085549
Tajima K; Kamura S; Ito S; Ito M; Nagatomo M; Kinoshita K; Ikeda S; Aichi Cancer Center Research Institute, Nagoya, Japan.
To extend the epidemiological study on adult T-cell leukemia-lymphoma (ATL) in Japan , the geographical and demographic characteristics of carriers of human T-lymphotropic virus type I (HTLV-I) and patients with ATL were analyzed in Tsushima Island, which is one of the typical endemi
Int J Cancer. 1987 Dec 15;40(6):755-7. Unique Identifier : AIDSLINE MED/88085551
Kusuhara K; Sonoda S; Takahashi K; Tokugawa K; Fukushige J; Ueda K; Department of Pediatrics, Faculty of Medicine, Kyushu University,; Fukuoka, Japan.
Okinawa prefecture is one of the endemic areas for adult T-cell leukemia/lymphoma (ATLL) in Japan . In this study, 2,013 serum specimens drawn serially over a period of 15 years (1968-1983) from 311 mother/child pairs in Okinawa were tested for antibodies to human T-cell leukemia vir
Seto A; Kawanishi M; Matsuda S; Ogawa K; Eguchi T; Miyoshi I; Department of Microbiology, Faculty of Medicine, Kyoto; University.
Two HTLV-I-carrying T cell lines were prepared from peripheral lymphocytes of a virus-infected (B/J X Chbb:HM) F1 rabbit, and these cells were inoculated intraperitoneally into 5 newborn F1 rabbits. These animals were killed 3-5 weeks later. Their leukocyte counts were higher than those in normal control animals, with
Hino S; Doi H; Yoshikuni H; Sugiyama H; Ishimaru T; Yamabe T; Tsuji Y; Miyamoto T; Department of Bacteriology, Nagasaki University School of; Medicine.
High-titer antibody against HTLV-I in carrier mothers is proposed as a secondary parameter for risk of viral transmission to the children via milk. For titration of antibodies, a less expensive modified gelatin particle agglutination assay (approximately 40% of the standard cost) was developed. None of 11 carrier moth
Umadome H; Uchiyama T; Hori T; Tamori S; Motoi T; Araki K; Uchino H; First Division of Internal Medicine, Faculty of Medicine, Kyoto; University, Japan.
Human T cell leukemia/lymphoma (T-lymphotropic) virus type I (HTLV-I) infection has been considered to be closely associated with the leukemogenesis of adult T cell leukemia (ATL), in which interleukin 2 ( IL-2 ) receptors are abnormally expressed. In this study, however
Shimoyama M; Ota K; Kikuchi M; Yunoki K; Konda S; Takatsuki K; Ichimaru M; Ogawa M; Kimura I; Tominaga S; et al; Hematology-Oncology Division, National Cancer Center Hospital,; Tokyo, Japan.
One hundred sixty-three patients with advanced non-Hodgkin s lymphoma including adult T cell leukemia/lymphoma (ATL) were treated from 1981 to 1983 with VEPA (vincristine, cyclophosphamide, prednisolone, and doxorubicin) or VEPA-M (VEPA plus methotrexate) in randomized fashion afte
Tenhunen R; Tokola O; Linden IB; Department of Clinical Chemistry, University Central Hospital of; Helsinki, Finland.
Intravenous administration of haem in acute hepatic porphyrias inhibits the induction of delta-aminolaevulinic acid synthase, reduces the formation of potentially harmful metabolites of porphyrin synthesis and corrects the haem deficiency. Typically, haem therapy has been given in the form of haematin--haem dissolved
Lancet. 1988 Jan 16;1(8577):76-81. Unique Identifier : AIDSLINE MED/88093256
Yarchoan R; Perno CF; Thomas RV; Klecker RW; Allain JP; Wills RJ; McAtee N; Fischl MA; Dubinsky R; McNeely MC; et al; National Cancer Institute, Bethesda, Maryland.
Five dose regimens of 2 ,3 -dideoxycytidine ( ddC ) were administered, intravenously for 2 weeks then orally for 4 or more weeks, to 20 patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC). ddC was well absorbed from the
N Engl J Med. 1988 Jan 28;318(4):219-22. Unique Identifier : AIDSLINE MED/88094595
Minamoto GY; Gold JW; Scheinberg DA; Hardy WD; Chein N; Zuckerman E; Reich L; Dietz K; Gee T; Hoffer J; et al; Department of Medicine, Memorial Sloan-Kettering Cancer Center,; New York, NY 10021.
Among 211 adults with leukemia who received multiple transfusions, 6 were found to be seropositive for human T-cell leukemia virus Type I (HTLV-I). Before the positive serum specimens were obtained, these patients received a mean of 14 units of red cells and 78 units of platelets. Seroconversion could be documented in
Ann Neurol. 1987 Nov;22(5):601-5. Unique Identifier : AIDSLINE MED/88105305
Miyai I; Saida T; Fujita M; Kitahara Y; Hirono N; Department of Neurology, Sumitomo Hospital, Osaka, Japan.
We studied two familial cases of human T-lymphotropic virus type I (HTLV-I)-associated myelopathy from the Kii Peninsula, an area of endemic adult T-cell leukemia-lymphoma (ATLL) in Japan . Incidence of familial clustering of HTLV-I-associated myelopathy was about 20%. Type C retrovi
Tardieu M; Blanche S; Rouzioux C; Veber F; Fischer A; Griscelli C; Unite de Neurologie, Hopital de Bicetre, Le Kremlin-Bicetre.
A prospective survey of 38 HIV1-infected infants has been performed. Thirty-four percent of the patients expressed neurological abnormalities. Three main clinical entities of various intensity have been defined: 8 patients had severe intellectual and motor dysfunctions associated with a bucco-lingual dyspraxia; in 4 p
Yoshiki T; Kondo N; Chubachi T; Tateno M; Togashi T; Itoh T; Department of Pathology, Sapporo City General Hospital, Japan.
Newborn WKA rats given a single intraperitoneal injection of MMC treated TARS-1, a rat T cell line producing HTLV-I, were shown to accumulate high titred antibodies specific for HTLV-I. Adult WKA rats rejected TARS-1 transplant with transient appearance of anti-HTLV-I antibodies. However, rats maintained under daily a
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