Pathology of Mycobacterium avium-intracellulare infection in acquired immunodeficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

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Pathology of Mycobacterium avium-intracellulare infection in acquired immunodeficiency syndrome.

Hum Pathol. 1987 Jul;18(7):709-14. Unique Identifier : AIDSLINE MED/87248722
Klatt EC; Jensen DF; Meyer PR

Abstract: The clinical setting, gross organ distribution, and microscopic pathologic findings of disseminated Mycobacterium avium-intracellulare (MAI) infection are described at autopsy in 12 patients with acquired immunodeficiency syndrome (AIDS). All patients were diagnosed by premortem mycobacterial cultures. The clinical course of MAI infection was often prolonged, and death was usually due to an additional infection. In every patient, the distinctive microscopic feature on hematoxylin--eosin staining was a poorly defined granuloma consisting of pale blue, striated histiocytes filled with mycobacteria. Well-formed granulomas with fibrosis, necrosis, and epithelioid histiocytes were present in less than one third of cases. MAI is an opportunistic pathogen that may complicate the course of AIDS but only rarely leads to death. The characteristic appearance of striated histiocytes may aid in the recognition of this infection.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult Human Intestine, Small/PATHOLOGY Lymph Nodes/PATHOLOGY Male Middle Age *Mycobacterium avium Opportunistic Infections/MICROBIOLOGY/*PATHOLOGY Spleen/PATHOLOGY Tuberculosis/COMPLICATIONS/MICROBIOLOGY/*PATHOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcomplicationsadulthumanintestine,small/pathologylymphnodes/pathologymalemiddleageKWDmycobacteriumaviumopportunisticinfections/microbiology/KWDpathologyspleen/pathologytuberculosis/complications/microbiology/KWDpathologyjournalarticle
871030
M87A0372

Copyright © 1987 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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