Interface dermatitis in patients with the acquired immunodeficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

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Interface dermatitis in patients with the acquired immunodeficiency syndrome.

J Am Acad Dermatol. 1987 Jun;16(6):1209-18. Unique Identifier : AIDSLINE MED/87251517
Rico MJ; Kory WP; Gould EW; Penneys NS

Abstract: We report twenty-five patients with the acquired immunodeficiency syndrome (AIDS) and interface dermatitis. Patients with AIDS and interface dermatitis had numerous opportunistic and herpetic infections. Nearly all patients were receiving at least one medication prior to the development of their rash and many were clinically thought to have a drug eruption. When compared to skin biopsy specimens from non-AIDS patients with drug eruptions, specimens from patients with AIDS and interface dermatitis demonstrated a greater degree of vacuolar change, the frequent occurrence of necrotic keratinocytes, often in clumps, and the absence of eosinophils and polymorphonuclear leukocytes in the dermal infiltrates. Histologic and clinical features of our patients with AIDS and interface dermatitis are presented and contrasted with other interface dermatitides. Systemic and cutaneous immune abnormalities in patients with AIDS may be relevant to the pathogenesis of this interface process.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult Biopsy Case Report Dermatitis/*ETIOLOGY/PATHOLOGY Epidermis/CYTOLOGY Female Human Keratin Male Neutrophils/PATHOLOGY Skin/*PATHOLOGY Support, Non-U.S. Gov't Vacuoles/ULTRASTRUCTURE JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcomplicationsadultbiopsycasereportdermatitis/KWDetiology/pathologyepidermis/cytologyfemalehumankeratinmaleneutrophils/pathologyskin/KWDpathologysupport,non-uKWDsKWDgov'tvacuoles/ultrastructurejournalarticle
871030
M87A0365

Copyright © 1987 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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