Viremia, antigenemia, and serum antibodies in rhesus macaques infected with simian retrovirus type 1 and their relationship to disease course.

Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

Viremia, antigenemia, and serum antibodies in rhesus macaques infected with simian retrovirus type 1 and their relationship to disease course.

Lab Invest. 1987 Jun;56(6):591-7. Unique Identifier : AIDSLINE MED/87255842
Kwang HS; Pedersen NC; Lerche NW; Osborn KG; Marx PA; Gardner MB

Abstract: The course of simian retrovirus type 1 (SRV-1) infection was studied in 14 experimentally inoculated juvenile rhesus monkeys. Viral transmembrane protein antigenemia and antibodies to whole virus were measured by enzyme linked immunosorbent assay and correlated with the clinical course of disease and virus isolation. Based on these parameters, animals with simian retrovirus type 1-induced disease were divided into three categories: monkeys dying within a few months of fulminating simian acquired immune deficiency syndrome in the face of a high level persistent antigenemia and viremia, and a nondetectable serum antibody response; monkeys that developed a milder form of simian acquired immune deficiency syndrome but remained alive in spite of a chronic low-grade antigenemia and viremia and only a transient initial antibody response; and monkeys that never became ill and that were either transiently or nontransiently viremic and antigenemic. This latter group developed high levels of serum antibodies. The outcome of simian retrovirus type 1-induced disease was similar to that described for feline leukemia virus infection of cats, another retroviral disease of animals. The disease course differed considerably, however, from that reported for retrovirus-induced human acquired immune deficiency syndrome.

Keywords: Acquired Immunodeficiency Syndrome/MICROBIOLOGY/*VETERINARY Animal Antibodies, Viral/*ANALYSIS Antigens, Viral/*ANALYSIS Enzyme-Linked Immunosorbent Assay Female Macaca mulatta Mice Mice, Inbred BALB C Monkey Diseases/IMMUNOLOGY/*MICROBIOLOGY Retroviridae/IMMUNOLOGY/*ISOLATION & PURIF Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Vaccination JOURNAL ARTICLE

871030
M87A0354

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