Chicago, Ill. : Year Book Medical Publishers, c1986 p. 362-409 : ill., port (Current problems in pediatrics, ISSN 0045-9380 ; v. 16, no. 7 (July 1986)) Unique Identifier : AIDSLINE CAT/8709557
Baltimore : Johns Hopkins University Press, 1987 x, 230 p. : ill (The Johns Hopkins series in contemporary medicine and public health) Unique Identifier : AIDSLINE CAT/8709097
Employers must face the fact that some of their employees may eventually develop AIDS. Yet many organizations still have not developed a comprehensive policy that addresses the issues of educating the workforce about this disease, testing for the virus, and pressuring insurance carriers to change their policies to all
Cancer. 1987 Aug 15;60(4):719-23. Unique Identifier : AIDSLINE MED/87243937
Ahmed T; Wormser GP; Stahl RE; Mamtani R; Cimino J; Glasser M; Mittelman A; Friedland M; Arlin Z
Certain neoplasia are closely associated with acquired immune deficiency syndrome (AIDS). To evaluate this relationship the authors reviewed the occurrence of lymphomas in populations at high risk for AIDS; the study population included prisoners from New York State and nonprisoner intravenous drug abusers (IVDA). Non
A case of heterotopic ossification (myositis ossificans) secondary to the central nervous system complications of acquired immune deficiency syndrome (AIDS) is reported. Because of the overwhelming suspicion of infection in this patient, this diagnosis was not considered until a gallium scan revealed the typical findi
Histopathologic findings in the central nervous system in 100 autopsy cases of the acquired immunodeficiency syndrome (AIDS) gave evidence of a variety of opportunistic infections and probably of infection by human immunodeficiency virus (HIV). Gliomesenchymal cell nodules (47 per cent of cases) and spongiform alterat
The clinical setting, gross organ distribution, and microscopic pathologic findings of disseminated Mycobacterium avium-intracellulare (MAI) infection are described at autopsy in 12 patients with acquired immunodeficiency syndrome (AIDS). All patients were diagnosed by premortem mycobacterial cultures. The clinical co
Clinical and pathologic observations made in a patient with inflammatory myopathy associated with the acquired immunodeficiency syndrome (AIDS) are presented. Multinucleated giant cells were a prominent histopathologic feature in the muscle biopsy samples. The findings indicate that in some patients with AIDS myositis
Int J Neurosci. 1987 Feb;32(3-4):647-59. Unique Identifier : AIDSLINE MED/87249446
Ostrow DG
As the AIDS epidemic has unfolded, a growing number of psychiatric consequences have been manifested. Based on his experiences as a researcher, clinician, and public health advisor, the author presents a number of conceptual models to assist in our understanding of the psychological, social and political consequences
Developmental abnormalities in 16 pediatric patients with AIDS or AIDS-Related Complex (ARC) were previously described. Neurological deterioration was in evidence on follow-up in 9 of the children, 5 died since the original assessments were performed. Ten patients were reevaluated 14 months later by cognitive testing.
To test the hypothesis that cognitive impairment may be present early in the course of HTLV-III/LAV infection, intravenous drug abusers (IDVAs) without overt symptoms of AIDS related illness were tested with standard neuropsychological and psychosocial measures. This study is the baseline for a prospective longitudina
The acquired immunodeficiency syndrome-related complex was identified in a mother and one of her nonidentical twins. Generalized lymphadenopathy was first noted in the infant at age 17 months, and that of the mother was incidentally discovered 6 months later. The father, who had had homosexual contacts before the conc
We report twenty-five patients with the acquired immunodeficiency syndrome (AIDS) and interface dermatitis. Patients with AIDS and interface dermatitis had numerous opportunistic and herpetic infections. Nearly all patients were receiving at least one medication prior to the development of their rash and many were cli
J Med Educ. 1987 Jul;62(7):549-56. Unique Identifier : AIDSLINE MED/87254163
Kelly JA; St. Lawrence JS; Smith S Jr; Hood HV; Cook DJ
More than most diseases, acquired immune deficiency syndrome (AIDS) appears to elicit highly negative, fearful, and prejudicial attitudes. In the study reported here, medical students read one of four patient vignettes. The vignettes were identical in content except that the patient was identified as having either AID
J Med Educ. 1987 Jul;62(7):557-61. Unique Identifier : AIDSLINE MED/87254164
Goldman JD
First-year students at a midwestern medical school are introduced to a comprehensive approach to the biological, psychological, and social aspects of acquired immune deficiency syndrome (AIDS). In a seven-week elective seminar (approximately 12 hours in length), the students view a television movie and a documentary f
Gan No Rinsho. 1987 Apr;33(5 Suppl):535-8. Unique Identifier : AIDSLINE MED/87254847
Fujisawa T; Yamaguchi Y
In summarizing the reports regarding cellular immunity in the household contacts of patients with malignant tumors, household contacts of patients with neuroblastoma, ostegenic sarcoma, malignant melanoma, breast cancer and colonic cancer demonstrated significantly higher reactivity against tumor associated antigens (
The histopathology and incidence of AIDS-related glomerulopathy was evaluated by renal biopsy (N = 24) or at autopsy in 159 patients, including 131 adults and 28 infants and children with AIDS. Thirty-five patients had overt clinical manifestations of renal disease characterized by a nephrotic syndrome with focal and
The course of simian retrovirus type 1 (SRV-1) infection was studied in 14 experimentally inoculated juvenile rhesus monkeys. Viral transmembrane protein antigenemia and antibodies to whole virus were measured by enzyme linked immunosorbent assay and correlated with the clinical course of disease and virus isolation.
Zimmerman BL; Haller JO; Price AP; Thelmo WL; Fikrig S
In a review of the clinical, radiographic and pathologic data of 36 patients with AIDS we found 29 with pulmonary infections (Cytomegalic virus, Pneumocystis carinii, etc.) and 7 who had varying types of lymphocytic infiltration and interstitial changes on chest radiographs but did not have opportunistic infection. Pa
Associated with the acquired immune deficiency syndrome (AIDS) is a wide spectrum of opportunistic infections and secondary cancers. Foremost among the cancers is an aggressive form of Kaposi s sarcoma (KS) that was rarely seen in the United States before 1981. The pathogenesis of this
Kaposi s sarcoma (KS) in the acquired immunodeficiency syndrome (AIDS) is a new and aggressive presentation of a previously rare malignancy. Variation in the clinical course of this disease and its response to treatment suggest that clinical or immunologic parameters may be important in its prognosis. A review of the
Techniques first developed for the treatment of classic Kaposi s sarcoma (KS) have been used with considerable success in acquired immune deficiency syndrome (AIDS) patients with the early stages of the epidemic form of KS. Single doses of radiation or larger amounts applied as fractionated doses can produce short-ter
Studies of classic, and especially African, Kaposi s sarcoma in the 1970s showed that both forms of the disease respond to cytotoxic chemotherapy. The agents that had proven effective against these forms of neoplasm were among the first to be tried for managing epidemic Kaposi s sarcoma (EKS). Thus far, single-agent r
Since the acquired immune deficiency syndrome (AIDS) burst into prominence in 1981, it has claimed victims at an exponential rate and taxed the resources of physicians, health workers, and social support agencies. A sizeable minority of AIDS patients, mainly male homosexuals, have been presented with epidemic Kaposi s
Trans R Soc Trop Med Hyg. 1986;80(6):965-6. Unique Identifier : AIDSLINE MED/87264714
Coker R; Wood PB
A minor change in the pattern of Kaposi s sarcoma has been noticed in north-east Zaire . This is characterized by a small increase of the number of confirmed diagnoses, together with the appearance of the disease amongst women, who tend to be of a younger age group. These data sugg
Aghadiuno PU; Jankey N; Barton EN; Patrick AL; Roberts L; Charles W; Hull-Drysdale B; Hinds G
A 27-year-old promiscuous male who denied homosexuality, intravenous drug abuse or having received blood transfusions, had disseminated Kaposi sarcoma. The aggressive nature of the tumor in a young man with the Acquired Immune Deficiency Syndrome (AIDS) presenting as lymphogranuloma venereum (LGV) is highlighted. The
Suhrland MJ; Koslow M; Perchick A; Weiner E; Greco MA; Colquhoun F; Muller WD; Burstein DE
Cytologic preparations from two cases of progressive multifocal leukoencephalopathy (PML) were obtained by stereotactically guided needle biopsies using computerized tomograms of the brain. Case 1 was a 32-year-old man with an acquired immunodeficiency syndrome-related complex. Case 2 was a 71-year-old man with chroni
Fifteen cases of Kaposi s sarcoma diagnosed by fine-needle aspiration biopsy were reviewed. The diagnosis was confirmed by tissue biopsy in eight of the cases. All of the patients were homosexual males, and 13 had a previous diagnosis of AIDS. The aspirates were obtained from enlarged lymph nodes (five cases), soft-ti
Am J Gastroenterol. 1987 Aug;82(8):766-8. Unique Identifier : AIDSLINE MED/87267505
Tom W; Aaron JS
Esophagitis due to an opportunistic infection in an immunocompromised host is not unusual. This is frequently attributed to Candida albicans. Torulopsis glabrata is similar however taxonomically distinct from C. albicans. Although found to be pathogenic in various organs, to date there have been only four reported cas
Am J Med. 1987 Jun 26;82(6B):88-92. Unique Identifier : AIDSLINE MED/87267718
Heseltine PN; Corrado ML
Norfloxacin, a new oral fluoroquinolone, has a spectrum of activity and pharmacology that suggest it may be useful in certain infections in which other agents are inactive or have anticipated toxicity. This report is an analysis of 61 compassionate requests for norfloxacin that resulted in 42 treatment courses. The re
Am J Med Sci. 1987 Jul;294(1):42-4. Unique Identifier : AIDSLINE MED/87267770
Maguire GP; Delorenzo LJ; Brown RB; Davidian MM
A patient with the acquired immunodeficiency syndrome (AIDS) had tuberculosis present as an endobronchial mass simulating bronchogenic carcinoma. Endobronchial tuberculosis may be another unusual manifestation of tuberculosis in patients with AIDS. This manifestation of tuberculosis may be missed unless there is a hig
The efficacy of bronchoalveolar lavage (BAL) in diagnosing pulmonary hemorrhage was studied in 51 immunosuppressed patients with new pulmonary infiltrates. Similar studies were performed in a control group of 8 nonimmunocompromised patients. Hemosiderin content in Prussian-blue-stained alveolar macrophages obtained by
Sinus histiocytosis massive lymphadenopathy (SHML) syndrome with hepatic involvement, occurring in a seven-year-old black female, is reported. Morphologic characterization of the hepatic lesion is accomplished utilizing conventional light, fluorescent and electron microscopy, and histochemical techniques and by compar
Can Med Assoc J. 1987 Jul 15;137(2):109-13. Unique Identifier : AIDSLINE MED/87243790
Boyko WJ; Schechter MT; Craib KJ; Willoughby B; Douglas B; Sestak P; McLeod WA; O'Shaughnessey M
In an ongoing prospective study of homosexual men conducted in Vancouver since November 1982, 87 cases of human immunodeficiency virus (HIV) seroconversion have been documented to date. Comparison of laboratory results obtained a mean of 4.9 months before and 5.4 months after the estimated date of seroconversion revea
FEBS Lett. 1987 Jun 29;218(2):231-7. Unique Identifier : AIDSLINE MED/87247276
Sternberg MJ; Barton GJ; Zvelebil MJ; Cookson J; Coates AR
Criteria for the design of peptide vaccines to prevent AIDS are presented. The best vaccine candidates contain both B and T lymphocyte-defined epitopes in regions conserved in sequence between viral isolates. We propose that attention should focus on proteins specified by the gag and, possibly, pol genes in addition t
Health care workers can reduce risks associated with caring for HIV seropositive individuals by strict adherence to routine infection control procedures. Educating personnel in infection control should be increasingly stressed in all health-related settings. When accidents occur, however, the health care industry must
This is a comparative ultrastructural study of human immunodeficiency virus (HIV) particles in infected H9 lymphocyte cultures and in the brain of a six-year-old boy with acquired immunodeficiency syndrome (AIDS) encephalopathy. Viral particles in the cultures and the brain were of various sizes and shapes; particles
Sera from virtually all individuals infected with human immunodeficiency virus contain antibodies against the viral envelope glycoproteins. By using a series of synthetic peptide antigens, we identified an immunodominant domain at amino acid position 598-609 of gp41. The minimal essential epitope is a 7-amino-acid seq
Balzarini J; Kang GJ; Dalal M; Herdewijn P; De Clercq E; Broder S; Johns DG
A series of 2 ,3 -didehydro-2 ,3 -dideoxyribonucleosides (ddeNs) [i.e., 2 ,3 -dideoxythymidinene (ddeThd), 2 ,3 -dideoxyuridinene (ddeUrd), 2 ,3 -dideoxycytidinene (ddeCyd), and 2 ,3 -dideoxyadenosinene (ddeAdo)] has been synthesized and the individual members compared in terms of their in vitro antiviral, antimetabol
Prachar J; Vrbenska A; Hlubinova K; Simkovic D; Kovarik A
Very small amounts of retrovirus-like particles were isolated from tissue culture media of various types of human cell lines derived from malignant as well as normal cells. The aim of the present study is the characterization of protein profiles of these isolates. The comparison of protein profiles of isolated human v
The etiologic agent of the acquired immunodeficiency syndrome is human immunodeficiency virus. We report here a case of the culturing of this agent from the placenta and suggest the clinical implications.
Biochem Biophys Res Commun. 1987 Jun 30;145(3):1080-6. Unique Identifier : AIDSLINE MED/87270673
Baba M; Pauwels R; Balzarini J; Herdewijn P; De Clercq E
3 -Azido-2 ,3 -dideoxyguanosine (AzddGuo) is a potent and selective inhibitor of human immunodeficiency virus (HIV) in vitro. AzddGuo completely inhibits HIV-induced cytopathogenicity and viral antigen expression in MT-4 cells at a concentration of 5.0 microM. Its 50% effective dose for inhibiting HIV-induced cytopath
Immune function was assessed in 93 adult hemophiliacs in the 2 years prior to HTLV-III antibody testing of blood donors and routine heat treatment of coagulation factor concentrates. Parameters of humoral and cellular immunity studied included serum complements, immunoglobulins, immune complexes, blood cell counts, ly
Ebbesen P; Melbye M; Jeffries J; Antonen J; Valle SL; Suni J; Ranki A; Krohn K; Chermann JC; Koch MA; et al
The ECP Working Group on AIDS has evaluated data on seropositivity to LAV/HTLV-III supplied by members in II Western European countries. The period covered is 1981-84. The rise in LAV/HTLV seropositivity parallels the incidence of cases of AIDS in the different countries. LAV/HTLV now spreads freely within Europe and
We mapped an immunodominant domain of the human immunodeficiency virus (HIV). We selected hydrophilic amino acid sequences encoded by conserved regions of the gag, pol, and env genes of HIV as potential antigenic domains. Eighteen peptides representing these sequences were synthesized; the peptides elicited strong ant
Prince AM; Pascual D; Kosolapov LB; Kurokawa D; Baker L; Rubinstein P
A semiautomated microtiter assay has been developed to quantitate neutralizing antibody to the human immunodeficiency virus. This assay has been found to be highly specific. Forty-four sera that were negative by enzyme-linked immunosorbent assay (ELISA) were tested under code: 42 were negative (less than 1:2), and 2 h
During the six months from October 1985 through March 1986, blood samples from 306,061 civilian applicants for military service from the United States were tested for antibody to the human immunodeficiency virus (HIV). Four hundred sixty subjects were positive for the antibody as deter
Biggemann B; Voit T; Neuen E; Wechsler W; Kramer H; von Kries R; Wahn V
We report the neurological findings in two children with AIDS and one child with lesser AIDS. The first patient developed acute encephalopathy 37 months after having received a blood transfusion from a HTLV-III positive donor. CCT showed ring-enhancement and hypodense lesions with homogenous enhancement. Autopsy revea
To investigate a possible protective role of HTLV-III neutralizing antibodies in individuals exposed to the virus, sera of children with acquired immunodeficiency syndrome or acquired immunodeficiency syndrome-related complex were analyzed for neutralizability of HTLV-IIIB infectivity. Twelve pediatric patients (nine
Although AIDS and HTLV-III/LAV infection are rare in adolescents, the number of infected adolescents in increasing. Adolescents may place themselves at risk for becoming infected through sexual exposure and use of intravenous drugs. The management of infected adolescents includes management of social, emotional, and p
HLA-A, B, DR antigens were determined in 46 patients, heavily transfused with blood products. Patients were 44 haemophiliacs, one case of afibrinogenemia and one case of von Willebrand s disease. Thirty-three patients had HIV antibodies. No significant difference for HLA antigen frequencies was observed in haemophilia
Am J Hematol. 1987 Jul;25(3):341-3. Unique Identifier : AIDSLINE MED/87267571
Jokela J; Flynn T; Henry K
A case of thrombotic thrombocytopenic purpura (TTP) in a human immunodeficiency virus (HIV)-seropositive homosexual man is reported. The patient improved after corticosteroid and plasma exchange therapy was instituted. The case demonstrated most of the classic features of TTP, including histologic evidence of fibrin t
Ito M; Nakashima H; Baba M; Pauwels R; De Clercq E; Shigeta S; Yamamoto N
Glycyrrhizin (GL), one of the plant extracts, was investigated for its antiviral action on the human immunodeficiency virus [HIV (HTLV-III/LAV)] in vitro, using cytopathic effect and plaque forming assay system in MT-4 cells (a HTLV-I-carrying cell line). Cloned Molt-4 cells (clone No. 8), which are sensitive to HIV a
Bone marrow biopsies and smears were examined from 70 patients with acquired immunodeficiency syndrome (AIDS) or AIDS related conditions: 32 patients with AIDS; 9, at risk, group patients with B-cell lymphoma; 22 patients with AIDS related complex (ARC) and 7, at risk, group patients with idiopathic thrombocytopenic p
Int J Neurosci. 1987 Feb;32(3-4):687-93. Unique Identifier : AIDSLINE MED/87249451
Hill JM; Farrar WL; Pert CB
Using a novel autoradiographic technique and a monoclonal antibody to T4, the entry protein for the AIDS virus HIV, we have determined the distribution of T4 in selected areas of the human brain. T4 was found throughout the human brain in a pattern similar to that seen in squirrel monkey and rat, thus demonstrating a
The cell cycle progression and viability of stimulated and intact lymphocytes from 20 subjects with acquired immune deficiency syndrome (AIDS) was determined by flow cytometry. As compared to controls, 62% less AIDS lymphocytes, cultured for 72 hr in the presence of lectins (Con-A, PHA, PWM), had entered the prolifera
Thirty-two patients with AIDS related complex (ARC) or acquired immunodeficiency syndrome (AIDS) underwent 67Ga scans as part of their evaluation. Three patterns of 67Ga biodistribution were found: lymph node uptake alone; diffuse pulmonary uptake; normal scan. Gallium-67 scans were useful in identifying clinically oc
Kramer EL; Sanger JJ; Garay SM; Greene JB; Tiu S; Banner H; McCauley DI
Eighty-six [67Ga]citrate chest scans were performed in 71 adult patients with the acquired immunodeficiency syndrome. Forty-five of these patients also had Kaposi s sarcoma. Only 29 of 57 abnormal scans were correlated with abnormal chest radiographs. Chest radiographs were negative for 27 scans and unavailable for on
Transthoracic needle biopsy of lung was performed under fluoroscopic guidance in 16 patients with AIDS or suspected AIDS for diagnosing 18 episodes of possible P carinii infection. Diagnostic information was obtained in 15 of 18 cases. P carinii (10) and other infections agents (5) were diagnosed by TNB. The complicat
Virus-specific cytotoxic T lymphocytes (CTL) which kill virus-infected cells are thought to be a major host defence against viral infections. Here we report the existence of human immunodeficiency virus (HIV)-specific CTL in persons infected with this virus, the aetiological agent of AIDS (acquired immunodeficiency sy
Plata F; Autran B; Martins LP; Wain-Hobson S; Raphael M; Mayaud C; Denis M; Guillon JM; Debre P
Human immunodeficiency virus (HIV) is implicated in the development of AIDS (acquired immune deficiency syndrome). HIV infection leads to the generation of HIV-specific thymus-derived (T) lymphocytes in humans and apes. We describe an experimental system permitting the quantitative and systematic analysis of HIV-speci
Proc Natl Acad Sci U S A. 1987 Aug;84(15):5404-8. Unique Identifier : AIDSLINE MED/87260994
Zolla-Pazner S; Des Jarlais DC; Friedman SR; Spira TJ; Marmor M; Holzman R; Mildvan D; Yancovitz S; Mathur-Wagh U; Garber J; et al
Blood specimens from 165 intravenous drug users who were seropositive for the human immunodeficiency virus (HIV), from 158 seropositive homosexual men with lymphadenopathy, and from 77 patients with acquired immunodeficiency syndrome (AIDS) were assessed immunologically. Immunologic parameters were analyzed by the Gut
Proc Natl Acad Sci U S A. 1987 Aug;84(15):5429-33. Unique Identifier : AIDSLINE MED/87260999
Arya SK
An in vitro transcription and translation procedure was designed to translate multiple open reading frames from cloned DNAs. For human immunodeficiency virus (HIV) cloned DNA carrying three open reading frames (sor, tat, and 3 -orf), the approach yielded three authentic polypeptides. Clearly, the internal initiation c
Simmons JT; Suffredini AF; Lack EE; Brenner M; Ognibene FP; Shelhamer JH; Lane HC; Fauci AS; Masur H
Chest radiographic abnormalities in patients with AIDS usually are associated with opportunistic infection or neoplasm. One hundred five patients with AIDS and clinical evidence of pneumonitis had chest radiographs and underwent bronchoscopy with bronchoalveolar lavage, transbronchial biopsy, or open-lung biopsy. Ches
Systemic corticosteroid therapy alone was administered to a patient with Pneumocystis carinii pneumonia associated with the acquired immunodeficiency syndrome. Substantial clinical improvement and almost complete chest radiographic resolution of parenchymal infiltrates occurred. Because spontaneous resolution of P. ca
The cytologic diagnosis of central nervous system (CNS) Toxoplasma gondii was established from the cerebrospinal fluid (CSF) in a patient with acquired immunodeficiency syndrome (AIDS) who presented with obstructive hydrocephalus and progressive obtundation. Free extracellular tachyzoites, phagocytized tachyzoites, an
A total of 152 sera from African subjects were tested for presence of antibody to human immunodeficiency virus using four enzyme immunoassays (EIA) marketed by Abbott Diagnostics, Organon Teknika, Wellcome and Diagnostics Pasteur respectively, an indirect immunofluorescence assay (IFA) and an immunoblot assay (IBA) as
Invest New Drugs. 1987;5 Suppl:S65-75. Unique Identifier : AIDSLINE MED/87249614
Bonnem EM
The alpha-interferons have been explored in a wide variety of clinical applications in cancer. Significant activity has been demonstrated in AIDS-related Kaposi s sarcoma, ovarian carcinoma, bladder carcinoma, malignant glioma, non-Hodgkin s lymphoma , chronic granulocytic leukemia,
Immunoglobulin isolated from sera of homosexual men infected with human immunodeficiency virus (HIV) inhibited the reverse transcriptase (RT) activity of HIV. The inhibitory activity was specifically directed against HIV RT, and not against other mammalian retrovirus RT, including human T-lymphotropic virus type I. Th
Gupta P; Balachandran R; Grovit K; Webster D; Rinaldo C Jr
The reverse transcriptase assay, antigen capture assay, and radioimmunoassay were compared for the detection of human immunodeficiency virus (HIV) in culture fluids of virus-infected lymphocytes. The reverse transcriptase assay and the antigen capture assay were compared for 962 samples, and the two tests displayed co
Lymphoblastoid interferon (Wellferon), a combination of at least 8 alpha-interferons, has been shown to be effective therapy in male chronic carriers of HBV infection, resulting in the loss of HBeAg and HBV-DNA in 50% of those treated. However, 0/8 women (5 Chinese) treated in this trial responded to treatment. Patien
Scully LJ; Lever AM; Yap I; Pignatelli M; Thomas HC
We have reviewed the results of treating over 100 HBV carriers with adenine arabinoside, adenine arabinoside monophosphate and lymphoblastoid interferon. In the homosexual group of carriers, adenine arabinoside and its monophosphate have no value. However, in this group, lymphoblastoid interferon will produce a respon
Adenine arabinoside (ARA-A) and its monophosphate (ARA-AMP) are potent inhibitors of hepatitis B virus, but they have not been shown to beneficially alter the natural history of chronic type B hepatitis. Analysis of responders to ARA-AMP therapy has shown that responses can be temporary and that truly long-term benefi
Weller IV; Brown A; Morgan B; Hawkins A; Briggs M; Waite J; Cameron CH; Tedder R
The future design of controlled trials of antiviral therapy which might include homosexual hepatitis B virus (HBV) carriers requires base-line data on the spontaneous rate of loss of HBeAg and the prevalence of human T-lymphotropic virus III (HTLV-III/LAV) infection. Fifty-one untreated HBsAg and HBeAg-positive homose
Immunofluorescent and immunoperoxidase monoclonal antibody-based techniques were used to demonstrate hepatitis B e antigen (HBeAg) and hepatitis B c antigen (HBcAg) display in the liver biopsy specimens of 45 chronic hepatitis B virus (HBV) carriers. Anti-human immunodeficiency virus (anti-HIV)-positive HBV carriers h
Srinivasan A; York D; Anand R; Goldsmith CS; Bohan C; Kalyanaraman VS
A molecular clone of human immunodeficiency virus (HIV) was transferred to rodent and primate monolayer cells by DNA transfection. Of the cell lines tested, all of them released viral particles as shown by reverse transcriptase assay and dot-blot hybridization. The viruses released from transfected cultures were able
Fischl MA; Richman DD; Grieco MH; Gottlieb MS; Volberding PA; Laskin OL; Leedom JM; Groopman JE; Mildvan D; Schooley RT; et al
We conducted a double-blind, placebo-controlled trial of the efficacy of oral azidothymidine ( AZT ) in 282 patients with the acquired immunodeficiency syndrome (AIDS) manifested by Pneumocystis carinii pneumonia alone, or with advanced AIDS-related com
Richman DD; Fischl MA; Grieco MH; Gottlieb MS; Volberding PA; Laskin OL; Leedom JM; Groopman JE; Mildvan D; Hirsch MS; et al
We conducted a double-blind, placebo-controlled trial of oral azidothymidine ( AZT ) in 282 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex. Although significant clinical benefit was documented (N Engl J Med 1987; 317
Approximately 95% of neoplasms in acquired immune deficiency syndrome (AIDS) patients are either Kaposi s sarcoma or non-Hodgkin s malignant lymphoma. Kaposi s sarcoma is by far the most prevalent malignancy found, although a marked increase in the incidence of predominantly high-grade B cell malignant lymphomas has a
The epidemic form of Kaposi s sarcoma (KS) that occurs in patients with the acquired immune deficiency syndrome (AIDS) produces lesions that, histopathologically, are indistinguishable from those of classical KS or of the endemic form of the disease seen in children and adults in certain areas of Africa. There are, ho
Schwarz A; Hoffmann F; L'age-Stehr J; Tegzess AM; Offermann G
The human immunodeficiency virus (HIV) is reportedly transmitted by sexual contact, sharing of infected needles among intravenous drug abusers, blood and blood products, artificial insemination, and kidney transplantation. This study reports on cornea and kidney recipients of two HIV-infected donors. HIV was transmitt
Vet Rec. 1987 May 9;120(19):454-9. Unique Identifier : AIDSLINE MED/87265327
Seale JR
AIDS is a slow virus disease caused by a lentivirus. The silent incubation period following infection usually lasts many years, during which the infected person is potentially infectious to others. Pathological changes accumulate imperceptibly. When major symptomatic disease develops it is eventually fatal. The epidem
Kuhnl P; Seidl S; Ray V; Kulkarni AG; Mba EC; Chandanayingyong D
Screening for human immunodeficiency virus (HIV) (LAV/HTLV-III) antibodies in 3 blood donor populations from India (n = 1,000), Nigeria (n = 500) and Thailand (n = 650; sampling in 1982) with a sensitive en
Barr PJ; Steimer KS; Sabin EA; Parkes D; George-Nascimento C; Stephans JC; Powers MA; Gyenes A; Van Nest GA; Miller ET; et al
Expression vectors were constructed for the production of various domains of the envelope gene product of the SF-2 isolate of human immunodeficiency virus (HIV) in the yeast Saccharomyces cerevisiae. Serum specimens from HIV seropositive blood donors reacted in immunoblot assays with recombinant polypeptides from both
Turner RR; Meyer PR; Taylor CR; Gill PS; Hofman FM; Nichols P; Rasheed S; Levine AM
Immunohistologic analysis of cellular changes in serial lymph node biopsies of eight patients with persistent generalized lymphadenopathy (PGL) syndrome was performed and correlated with clinical and laboratory findings to better determine the natural history of human immunodeficiency virus (HIV) infection. The author
Am J Epidemiol. 1987 Aug;126(2):310-8. Unique Identifier : AIDSLINE MED/87267534
Kaslow RA; Ostrow DG; Detels R; Phair JP; Polk BF; Rinaldo CR Jr
The Multicenter AIDS Cohort Study was designed to elucidate the natural history of the infection causing acquired immunodeficiency syndrome (AIDS), identify risk factors for occurrence and clinical expression of the infection, and establish a repository of biologic specimens for future study. A variety of recruitment
Ann Intern Med. 1987 Aug;107(2):234-42. Unique Identifier : AIDSLINE MED/87268980
Seligmann M; Pinching AJ; Rosen FS; Fahey JL; Khaitov RM; Klatzmann D; Koenig S; Luo N; Ngu J; Riethmuller G; et al
Recent advances in the understanding of the pathogenesis of infection with human immunodeficiency virus (HIV) stems from the demonstration that the membrane glycoprotein, CD4, is the cellular receptor for HIV. This glycoprotein is found mainly on the surface of a major subpopulation of T lymphocytes and also on macrop
Vrang L; Bazin H; Remaud G; Chattopadhyaya J; Oberg B
3 -Azido-3 -deoxythymidine triphosphate (erythro) and its threo isomer were synthesized and investigated for their inhibition of HIV reverse transcriptase from virus isolate U 937/HTLV-III. The erythro isomer was a competitive inhibitor of the reaction directed by (rA)n(dT)12-18 and the Ki value was 0.0022 microM. The
Biochem Biophys Res Commun. 1987 Jun 30;145(3):1356-61. Unique Identifier : AIDSLINE MED/87270713
Herzyk P; Beveridge A; Neidle S
The low-energy conformations of 3 -azido-3 -deoxy-thymidine, ( AZT ), an inhibitor of retroviral reverse transcriptase, have been studied by molecular mechanics techniques. A force-field has been developed for the azido group by quantum-mechanical metho
Because there have been reports that factor IX concentrate is less immunosuppressive and therefore factor IX users have less immunologic aberrations, we have studied a group of 22 patients with hemophilia B and six patients with factor VIII deficiency and high titer inhibitors with respect to lymphocyte numbers and fu
Br Med J (Clin Res Ed). 1987 May 9;294(6581):1185-6. Unique Identifier : AIDSLINE MED/87243270
Parkin JM; Eales LJ; Galazka AR; Pinching AJ
Six patients with the acquired immune deficiency syndrome (AIDS) had exacerbations or recurrences of previously quiescent atopic disease when they developed immunodeficiency. Four developed a different atopic illness from that suffered previously. Atopic symptoms developed within three months after the patients develo
Matheson DS; Green BJ; Fritzler MJ; Poon MC; Bowen TJ; Hoar DI
Hemophiliacs require frequent infusions of allogeneic proteins to control bleeding. Previous reports have demonstrated that thymus-derived lymphocytes (T cells) from hemophiliacs are antigenically primed to the lyophilized antihemophilic factor and that natural killer cells from hemophiliacs demonstrate impaired respo
Human immunodeficiency virus (HIV) seroconversion among 40 Swedish haemophilia A patients has been investigated by retrospective sera testing. 22/40 patients had developed HIV antibodies before 1983, i.e., when heat-treatment of American factor concentrates was introduced. All patients had received American and Swedis
FEBS Lett. 1987 Jun 22;218(1):81-6. Unique Identifier : AIDSLINE MED/87247266
Samuel KP; Seth A; Konopka A; Lautenberger JA; Papas TS
The primary amino acid sequence within a stretch of 25 residues (positions 91-116) of the middle portion of the 3 -orf protein (p27(3 )-orf) of the human immunodeficiency virus (HIV) shares structural homology with a highly charged region within the intracytoplasmic phosphorylation domain of human interleukin-2 recept
Daniels TE; Greenspan D; Greenspan JS; Lennette E; Schiodt M; Petersen V; de Souza Y
Oral hairy leukoplakia (HL) is a recently described manifestation of human immunodeficiency virus (HIV) infection in which Epstein-Barr virus (EBV) has been shown to replicate. To seek evidence for a local defect in mucosal immunity, we assessed the presence of epithelial Langerhans cells (LC) in these lesions and in
A phylogenetic tree for the human lymphadenopathy-associated virus (LAV), the human T-cell lymphotrophic virus type III (HTLV-III), and the acquired immune deficiency syndrome (AIDS)-associated retrovirus (ARV) has been constructed from comparisons of the amino acid sequences of their gag proteins. A method is propose
Infectious complications have been, and will continue to be, a problem in recipients of blood transfusions. Steps to exclude high-risk donors and to test for antibody to HIV, antibody to hepatitis B core antigen, and alanine aminotransferase almost surely have a beneficial effect on the blood supply. The risk of trans
Kaposi s sarcoma (KS) is the major neoplastic complication of the acquired immune deficiency syndrome (AIDS). Although most patients succumb to infectious complications of AIDS rather than as a direct consequence of the tumor, KS may, in some cases, pursue an aggressive clinical course resulting in considerable morbid
The role of nutritional factors in the management of acquired immunodeficiency syndrome-related, or epidemic, Kaposi s sarcoma (EKS) is complex, since there are known interactions between malnutrition, immunodeficiency, and cancer. Malnutrition is a well-established cause of immune aberrations, which are seen in defic
Vilmer E; Rhodes-Feuillette A; Rabian C; Benbunan M; Meletis J; Devergie A; Bourrhis JH; Gluckman JC; Chermann JC; Gluckman E
The diagnosis of transfusion-associated acquired immunodeficiency syndrome (AIDS) was made in 2 patients who developed delayed opportunistic infections and severe cytopenias--56 months for the former (patient 1) and 22 months for the latter, (patient 2) following bone marrow transplantation (BMT) for aplastic anemia.
Tumori. 1987 Jun 30;73(3):273-8. Unique Identifier : AIDSLINE MED/87264875
Maggi E; Macchia D; Parronchi P; Milo D; Romagnani S
A total of 76 T-cell clones established from peripheral blood (PB) of 2 patients with the acquired immune deficiency syndrome (AIDS) and of 141 T-cell clones established from PB of 3 normal donors were compared for their ability to produce interleukin 2 ( IL-2 ) and gamm
The effect of 3 -azido-2 ,3 -dideoxythymidine ( AZT ) on the human immunodeficiency virus (HIV)-associated giant cell formation was studied in vitro. For this purpose we developed a coculture system using Molt-4 and its virus-producing cell, Molt-4/HTLV
Incubation of an AHF concentrate with 0.3% tri(n-butyl)phosphate (TNBP) and 0.2% sodium cholate was shown to inactivate at least 10,000 infectious doses of lipid-enveloped viruses, including hepatitis B and non-A, non-B viruses and HTLV-III [Prince et al., Lancet i, pp. 706-710, 1986]. The use of TNBP/detergent combin
Low serum cobalamin levels in 10 patients with AIDS or AIDS-related complex led us to also prospectively survey 40 homosexual men in our AIDS clinic. 8 of the latter (20%) had low cobalamin values. We found no evidence of megaloblastic changes in the blood or bone marrow. Assessment disclosed malabsorption of cobalami
Maccario R; Arico M; Ugazio A; Plebani A; Montagna D; Avanzini A; Marseglia G; Caselli D; Burgio G
The phenotype and functions of T lymphocytes and of natural killer (NK) cells have been investigated in four children and five adults from three Italian families infected with HIV (LAV/HTLV III). The results show a heterogeneous pattern of immunological derangements involving distribution of T and natural killer subse
Pifer LL; Niell HB; Langdon SB; Baltz S; Clark ST; Edwards CC; Woods DR
Heterosexual controls were found to have significantly higher titers of immunoglobulin G antibody to Pneumocystis carinii than did patients with the acquired immunodeficiency syndrome (AIDS) and P. carinii pneumonitis, human immunodeficiency virus (HIV) antibody-positive or -negative homosexual male gay bar patrons, a
Nature. 1987 Jun 25-Jul 1;327(6124):710-3. Unique Identifier : AIDSLINE MED/87258186
Stricker RB; McHugh TM; Moody DJ; Morrow WJ; Stites DP; Shuman MA; Levy JA
Patients with the acquired immune deficiency syndrome (AIDS) and AIDS-related conditions are known to have abnormalities of T cell subpopulations, including a decreased helper/inducer (bearing the CD4 antigen) to suppressor/cytotoxic (bearing the CD8 antigen) T cell ratio and decreased absolute numbers of T cells with
Nature. 1987 Jun 25-Jul 1;327(6124):716-7. Unique Identifier : AIDSLINE MED/87258188
Larder BA; Purifoy DJ; Powell KL; Darby G
Human immunodeficiency virus (HIV) is the causative agent of AIDS (acquired immune deficiency syndrome) a disease which poses a serious challenge to modern medicine. If we are to conquer this disease we will need a protective vaccine or effective drugs able to block the life cycle of the virus. An early stage in the i
The in vitro effects of thymosin fraction 5 (TF5) and lithium chloride (LiCl) on the ability of peripheral blood mononuclear cells (PBMC) obtained from 37 normal male donors and 33 male patients with AIDS-related complex (ARC) to respond to alloantigenic stimulation (mixed leukocyte reaction, MLR) and to produce inter
Srinivasan A; Anand R; York D; Ranganathan P; Feorino P; Schochetman G; Curran J; Kalyanaraman VS; Luciw PA; Sanchez-Pescador R
To examine the genetic relatedness of human immunodeficiency viruses (HIV) from different geographic locations, we molecularly cloned the genome of HIV isolated from a Zairian AIDS patient. Restriction mapping of the recombinant clone, designated HIV-Zr6, revealed both common (as observed in other HIV isolates) and un
Viral infections, predominantly those of the herpes virus family, account for up to 16% of all clinically significant infections in AIDS patients. Acyclovir has provided successful treatment in AIDS patients suffering from severe herpes simplex and herpes zoster virus infections
Int J Tissue React. 1987;9(3):195-8. Unique Identifier : AIDSLINE MED/87249517
Macchi B; Popovic M; Allavena P; Rossi P; Gallo RC; Bonmassar E
Infection with human T-cell leukaemia/lymphoma (HTLV-I) preferentially affects T cells of the OKT-4 phenotype. The aim of the present study was to determine whether distinct T-cell subsets exhibit differences in susceptibility to virus infection. T cells from peripheral blood were separated according to cell densities
Three patients with acquired immunodeficiency syndrome were noted to have skin lesions in which there were histologic changes supporting the presence of both fungal and viral pathogens. Skin lesions were found in the patellar region in two patients and in the groin in one patient. Skin biopsies revealed massive epider
Gerberding JL; Bryant-LeBlanc CE; Nelson K; Moss AR; Osmond D; Chambers HF; Carlson JR; Drew WL; Levy JA; Sande MA
This prospective cohort study was designed to evaluate the risk of occupational transmission of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and cytomegalovirus ( CMV ) to health care workers with intensive expo
Patients with gastrointestinal symptoms may not associate their problems with sexual activities or be unwilling to admit to homosexuality. The diagnosis may be delayed or missed and sexual partners are unlikely to be investigated. To complicate matters further the clinical manifestations of some infections may be mark
Bovine leukemia virus (BLV) gene expression is exquisitely regulated at multiple levels, including a transcriptional control effected by virus-encoded trans-acting factors and cis-acting target sequences. Like the human T-cell leukemia viruses type I and type II, but unlike other RNA tumor viruses, BLV contains severa
Sleckman BP; Peterson A; Jones WK; Foran JA; Greenstein JL; Seed B; Burakoff SJ
The CD4 (T4) antigen was originally described as a phenotypic marker specific for helper T cells, and has recently been shown to be the receptor for the human immunodeficiency virus (HIV). Functional studies using monoclonal antibodies directed at CD4 and major histocompatibility complex (MHC) class II molecules led t
The lymphocyte differentiation antigen CD4 serves as a receptor for human retroviruses associated with acquired immunodeficiency syndrome (AIDS) through its interaction with the major envelope virion glycoprotein, gp120, which is also expressed on the surface of infected cells. In these experiments, purified gp120 was
Proc Natl Acad Sci U S A. 1987 Jul;84(14):4919-23. Unique Identifier : AIDSLINE MED/87260900
Rosen CA; Park R; Sodroski JG; Haseltine WA
The U3 region of the long terminal repeat (LTR) of human T-cell leukemia virus type I (HTLV-I) contains sequences that respond to the trans-activating transcription (tat) factor encoded by the pX region of the provirus. Results presented here show that there are multiple tat-responsive sequences within the LTR and tha
Proc Natl Acad Sci U S A. 1987 Jul;84(14):4994-8. Unique Identifier : AIDSLINE MED/87260915
Krohn K; Robey WG; Putney S; Arthur L; Nara P; Fischinger P; Gallo RC; Wong-Staal F; Ranki A
Animals immunized with native or recombinant envelope proteins from the human immunodeficiency virus (HIV, formerly referred to as human T-lymphotropic virus type III) human T-lymphotropic virus type IIIB and naturally HIV-infected men were assessed for neutralizing antibodies and cell-mediated immunity toward the vir
Proc Natl Acad Sci U S A. 1987 Aug;84(15):5389-93. Unique Identifier : AIDSLINE MED/87260991
Siekevitz M; Feinberg MB; Holbrook N; Wong-Staal F; Greene WC
Cotransfection of cDNA encoding the trans-activator gene product of human T-cell leukemia virus, type I (HTLV-I) (tat-I), which acts in trans to augment viral gene expression, has revealed strong regulatory effects of this viral protein on the inducible cellular promoters governing human interleukin 2 (
Interactions between retroviruses associated with acquired immunodeficiency syndrome and their receptors on lymphocytes represent the initial steps in the process of infection and are also involved in multinucleated giant cell formation, which is one form of virus-mediated cytopathology. The exterior envelope glycopro
Substantial advances have already been made in the understanding of acquired immunodeficiency syndrome (AIDS). The major issues for AIDS research during the next few years must be practical ones: the development of a safe, effective vaccine for individuals not yet infected with the causative virus and the development
Rifabutin (ansamycin LM 427), a semisynthetic spiropiperidyl derivative of rifamycin S, shows good in vitro activity against most mycobacterial species, including Mycobacterium avium complex. In animal models, the drug is more active against both Mycobacterium tuberculosis and Mycobacterium leprae than in rifampin, an
Science. 1987 Jun 26;236(4809):1671-4. Unique Identifier : AIDSLINE MED/87263352
Sharpe AH; Jaenisch R; Ruprecht RM
A murine model in which neurotropic retroviral infection can be studied over short periods of time was developed. Microinjection of Cas-Br-E virus into midgestation mouse embryos caused paralysis and death within 25 days after birth, in contrast to virus-infected neonates which develop disease only after 4 months. To
The acquired immune deficiency syndrome (AIDS) results in a T lymphocyte deficiency and, consequently, a susceptibility to opportunistic infections with organisms that previously were better known as causes of disease in patients with Hodgkin s disease or recipients of immunosuppressive therapy. Pneumocystis carinii,
Serological and immunochemical analysis of T cell clones generated from an HLA-DR3, DR7 donor detected a lower expression of HLA-DR3 than of HLA-DR7 antigen. The defect in the expression of HLA-DR3 antigen appears to reflect abnormalities in regulatory mechanism(s), since the cell surface expression of this antigen co
The methods of molecular hybridization are described using 32P-labeled plasmid pBHIO carrying the cloned HTLV-III provirus employed for the detection of HTLV-III-specific sequences in lines of T-lymphocytes from patients with acquired immune deficiency syndrome. The presence of virus-specific sequences was demonstrate
A 29-year-old homosexual male with AIDS presented with progressive encephalopathy and cytomegalovirus ( CMV ) pneumonia. Neuropathological examination revealed toxoplasma abscesses in corpus callosum, basal ganglia and cerebell
Am J Hematol. 1987 Jun;25(2):203-10. Unique Identifier : AIDSLINE MED/87267550
Goldsmith JM; Variakojis D; Phair JP; Green D
Early reports suggested that hemophiliacs with factor IX deficiency (Christmas Disease) may be at less risk for developing the acquired immunodeficiency syndrome (AIDS) than patients with classic hemophilia. We evaluated 12 factor IX deficient patients for clinical and immunologic abnormalities related to infection wi
Am J Pathol. 1987 Jul;128(1):104-10. Unique Identifier : AIDSLINE MED/87267973
Chalifoux LV; Ringler DJ; King NW; Sehgal PK; Desrosiers RC; Daniel MD; Letvin NL
A T-cell tropic lentivirus of macaques the simian immunodeficiency virus (SIV), has morphologic, growth, and antigenic properties that indicate that it is related to the human immunodeficiency virus (HIV), the etiologic agent of the acquired immune deficiency syndrome (AIDS) in humans. Six juvenile macaques developed
9-(1,3-dihydroxy-2-propoxymethyl) guanine (ganciclovir) was used to treat 41 patients (median age, 37 years) with the acquired immunodeficiency syndrome and cytomegalovirus gastrointestinal infection. Sites of infection were the colon in 31, the esophagus in 5, the rectum in 4, and
Br Med J (Clin Res Ed). 1987 Jan 17;294(6565):143-4. Unique Identifier : AIDSLINE MED/87243232
Denning DW; Anderson J; Rudge P; Smith H
A 29 year old white homosexual man presented with a two and a half week history of severe sore throat, fever, and extreme fatigue. His symptoms did not respond to antibiotics. He had mild bilateral conjunctivitis, a rash over his chest and back, and enlarged lymph nodes, but examination of the nervous system yielded n
FEBS Lett. 1987 Jun 22;218(1):87-92. Unique Identifier : AIDSLINE MED/87247267
Sasaki T; Hasegawa-Sasaki H
Polyphosphoinositide hydrolysis was studied in membranes prepared from a human T cell leukemia line, JURKAT, prelabeled with myo-[2-3H]inositol. The formation of inositol bis- and trisphosphates was stimulated in a buffer with 110 nM free Ca2+ with a nonhydrolyzable GTP analogue, GTP gamma S, and NaF plus AlCl3 in a t
Expression of the granulocyte antigen Leu M-1 is characteristic of Reed-Sternberg cells and the related mononuclear cells of Hodgkin s Disease. Leu M-1 has been proposed as a specific immunological marker for Hodgkin s Disease which may be otherwise difficult to distinguish both morphologically and immunologically fro
Macchi B; Popovic M; Allavena P; Ortaldo J; Rossi P; Gallo RC; Bonmassar E
T4 subpopulation of T lymphocytes is the preferential target of infection with human T leukemia/lymphoma virus of subgroup I (HTLV-I). In this study we attempt to determine whether different T-cell subsets exhibit differences in susceptibility to virus infection. T cells from cord or peripheral blood were separated ac
10 patients with the acquired immunodeficiency syndrome whose respiratory failure due to Pneumocystis carinii pneumonia (PCP) was deteriorating rapidly had 7 days of intravenous methylprednisolone added to their antibiotic regimen. 8 similar patients were treated with antibiotic therapy alone. 9 of the 10 methylpredni
Four of five patients with AIDS and pulmonary infection had syncopal reactions as a result of fine-needle aspiration of the lung; in one patient the reaction was fatal. Subsequently, in one of these patients and four further patients with AIDS or human immunodeficiency virus (HIV) infection, the autonomic nervous syst
Paired serum and saliva specimens were tested by conventional assays and by IgG-capture radioimmunoassays (GACRIA) and enzyme-linked immunosorbent assays (GACELISA) for antibody to hepatitis A virus (HAV, 100 pairs), human immunodeficiency virus (HIV, 53), hepatitis B virus core (HBc, 62), and rubella virus (30). Conv
Karpas A; Hayhoe FG; Hill F; Anderson M; Tenant-Flower M; Howard L; Oates JK
Commercial enzyme-linked immunosorbent assays for HIV-1 infection often fail to detect antibodies to HIV-2. A simplified version of the HIV cell test detects antibodies to this new virus and enables typing of HIV infections. Since sera from 3 macaque monkeys infected with simian immunodeficiency virus gave weakly posi
For detection of antibody to bovine leukemia virus (BLV) major core protein of p24 and cross-reactive antibody in human patients infected with human T cell leukemia virus type I (HTLV-I), monoclonal antibody, D432 against BLV p24 was used by competitive binding enzyme-linked immunoadsorbed assay (ELISA). In sera from
Human leukemic T cells carrying a t(10;14)(q24;q11) chromosome translocation were fused with mouse leukemic T cells, and the hybrids were examined for genetic markers of human chromosomes 10 and 14. Hybrids containing the human 10q+ chromosome had the human genes for terminal deoxynucleotidyltransferase that has been
Kamihira S; Nakasima S; Oyakawa Y; Moriuti Y; Ichimaru M; Okuda H; Kanamura M; Oota T
The human T cell lymphotropic virus type I (HTLV-I) is transmitted by blood transfusions that contain cell components as one of the virus transmission modes. We carried out mass screening of sera from seropositive donors by a gelatin particle agglutination test to prevent the spread of HTLV-I by transfusion. Seroconve
Hasui K; Sato E; Hansmann ML; Tokudome T; Tokunaga M
A simultaneous microcytometric analysis of nuclear DNA content and size was performed in 8 European peripheral T cell lymphomas (EPTL) and 8 adult T-cell leukemia/lymphomas (ATLL), comparing their patterns on the nuclear density scattergram (NDS) of DNA content versus nuclear size. The intermingling lymphocytes with o
Studies of adult T-cell leukaemia virus/human T-cell leukaemia/lymphotropic viruses (ATLV/HTLV-I) in Japan indicate that the virus is involved only with the development of ATL. By contrast, reports from the U.S.A. about HTLV have from time to time claimed that related HTLV are conce
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