Monoclonal integration of HTLV-I proviral DNA in patients with strongyloidiasis. NLM AIDSLINE Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

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Monoclonal integration of HTLV-I proviral DNA in patients with strongyloidiasis.

Int J Cancer. 1987 Aug 15;40(2):145-8. Unique Identifier : AIDSLINE MED/87278680
Nakada K; Yamaguchi K; Furugen S; Nakasone T; Nakasone K; Oshiro Y; Kohakura M; Hinuma Y; Seiki M; Yoshida M; et al

Abstract: The relationship between strongyloidiasis and HTLV-I was investigated in Okinawa, an area where both conditions are endemic. Thirty-six patients with strongyloidiasis were seropositive for HTLV-I and suffered from several related clinical complications. Fourteen of these patients (39%) were shown to have monoclonal integration of HTLV-I proviral DNA in their blood lymphocytes, a condition designated as smouldering adult T-cell leukaemia (ATL). Monoclonal integration of proviral DNA correlated with an increased CD4/CD8 ratio and the presence of abnormal lymphocytes in the peripheral blood, and with a trend for greater severity of the parasitic infection. Although the immunodeficiency caused by HTLV-I could predispose to hyperinfestation by Strongyloides, it is also possible that both the parasitic and the retroviral infestations are important co-factors leading to the development of ATL.
Keywords: Adult Aged Antibodies, Monoclonal/IMMUNOLOGY Antibodies, Viral/ANALYSIS DNA, Viral/*ANALYSIS Female Human HTLV-BLV Infections/COMPLICATIONS HTLV-BLV Viruses/*GENETICS Lymphocytes/IMMUNOLOGY Male Middle Age Strongyloidiasis/COMPLICATIONS/*MICROBIOLOGY Support, Non-U.S. Gov't JOURNAL ARTICLE

KWDadultagedantibodies,monoclonal/immunologyantibodies,viral/analysisdna,viral/KWDanalysisfemalehumanhtlv-blvinfections/complicationshtlv-blvviruses/KWDgeneticslymphocytes/immunologymalemiddleagestrongyloidiasis/complications/KWDmicrobiologysupport,non-uKWDsKWDgov'tjournalarticle
871130
M87B0054

Copyright © 1987 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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