First IUIS Conference on Clinical Immunology. July 5-6, 1986, Toronto, Canada, 1986. Unique Identifier : AIDSLINE ICDB/87634547
Anonymous; No affiliation given
The First International Union of Immunological Societies (IUIS) Conference on Clinical Immunology held July 5-6, 1986, in Toronto, Canada , consisted of two plenary sessions (one on receptor-antireceptor mediated diseases, and the other on highlights in clinical immunology); nine co
The Pathology of Incipient Neoplasia. Henson DE, Albores-Saavedra J, eds. Philadelphia, W.B. Saunders Company, p. 87-115, 1986.. Unique Identifier : AIDSLINE ICDB/87635869
Jaffe ES; Hematopathology Section, Lab. of Pathology, NCI, Bethesda, MD
The lymphoid system is distinguished from many other systems by the fact that although polyclonal reactive lymphoid hyperplasias are relatively common, benign tumors of lymphoid cells, namely, benign monoclonal tissue proliferations, have not been recognized. Similarly, the concept of carcinoma in situ has not been
The Pathology of Incipient Neoplasia. Henson DE, Albores-Saavedra J, eds. Philadelphia, W.B. Saunders Company, p. 367-80, 1986.. Unique Identifier : AIDSLINE ICDB/87635885
Albores-Saavedra J; Univ. of Miami Sch. of Medicine, Miami, FL
The preinvasive stage of many carcinomas arising in squamous or glandular epithelia is well established, but the precursor lesions of nearly all soft-tissue sarcomas are unknown. As a rule, benign soft-tissue tumors do not become malignant. The author was aware of only a few sarcomas that arise in preexisting benign l
Cancer Chemother; 8:305-32 1986. Unique Identifier : AIDSLINE ICDB/87636524
Chachoua A; Oratz R; Green M; Muggia FM; Dept. of Medicine, New York Univ. Medical Center, 550 First; Avenue, New York, NY 10016
The focus of current investigations concerning acquired immune deficiency syndrome (AIDS) is on the development of effective antiviral agents, on immune-modifying strategies, and on anti-HTLV-III vaccines. Several studies have been in progress on the treatment of the malignancies, particularly Kaposi s sarcoma (KS), a
A variety of haematologic abnormalities are associated with infection by HIV, the human retrovirus that is the primary aetiologic agent of the acquired immunodeficiency syndrome (AIDS). We have reviewed the haematologic findings in well-characterized cohorts of patients with AIDS, AIDS-related complex (ARC) and asympt
Classic immune thrombocytopenia purpura (ITP) occurs predominantly in women and is associated with either normal or impaired Fc receptor-mediated clearance of antibody-coated cells. Recently, an increasing incidence of thrombocytopenia has been observed in homosexual men, but whether Fc receptor-mediated clearance of
Petat E; Carteron B; Reguer M; Lemmens P; Vandepitte J; Ghysels G
Data are presented on 633 strains of Shigella, and 197 strains of Salmonella, isolated in Bujumbura, capital of Burundi , between 1980 and 1985. The epidemiology of shigellosis is dominated by the resurgence of the Shiga bacillus and by its increasing resistance against all availab
To investigate some humoral aspects which may reflect the involvement of B lymphocytes in the acquired immunodeficiency syndrome (AIDS), we used an enzyme-linked immunoassay (ELISA) to determine the levels of IgM, IgG and IgA rheumatoid factors (RF) in 16 patients suffering from full-blown AIDS and 32 patients with AI
The gallium scans of seven AIDS patients who cultured positive for atypical mycobacterium were reviewed. Six cultured positive for Mycobacterium avium intracellulare, while one for Mycobacterium xenopi. A patchy uptake pattern of gallium in the lungs of these patients was identified.
Niland-Weiss J; Azen SP; Odom-Maryon T; Lui F; Hagerty C
This paper describes the details of a microcomputer-based, distributed data management system in the acquisition of data collected in a large multicentered cooperative investigation of transfusion-transmitted acquired immunodeficiency syndrome (AIDS). Clinical, virological, and immunological data are obtained from six
A case of biopsy documented subacute encephalopathy of AIDS was evaluated by CT and MRI. CT scanning revealed ventriculomegaly and ill-defined nonspecific periventricular white matter hypodensities. MRI, however, demonstrated extensive unequivocal diffuse white matter disease as the cause of the ventriculomegaly. MRI
Aside from opportunistic infections, several neoplasms have been identified as part of the spectrum of acquired immunodeficiency syndrome (AIDS) as defined by the Centers for Disease Control. Kaposi s sarcoma (KS) was the first such neoplasm to be recognized within the spectrum of AIDS. Although the classic form of Ka
Four black men with the acquired immunodeficiency syndrome (AIDS) demonstrated profound alterations in hair patterns two to three years after their first symptoms appeared. The hair became longer, lighter, softer, and silky, and it was occasionally discolored. One patient was thought to be of Indian extraction. These
Children with AIDS and related complexes present a new and serious challenge to the child welfare field s foster care system. At this stage of the world s knowledge of AIDS and treatment capacity for its victims, the children are stigmatized as plague bearers, their viability is unknown, and few, if any, will ever hav
Dev Biol Stand. 1987;67:221-8. Unique Identifier : AIDSLINE MED/87276910
Boucher DW; Furesz J
Blood products are considered as biological drugs in Canada and are regulated under The Food and Drugs Act. Before a biological drug may be sold, the manufacturer must file a new drug submission with the Bureau of Biologics and receive a notice that the submission complies with the
Dev Biol Stand. 1987;67:229-32. Unique Identifier : AIDSLINE MED/87276911
Graham DT
The regulatory processes for therapeutic goods in Australia will be outlined with particular emphasis on the Federal Government s policy toward marketing of blood and related products and its role in the regulation of these therapeutic goods. Aspects which will also be briefly a
Dev Biol Stand. 1987;67:291-302. Unique Identifier : AIDSLINE MED/87276919
Horowitz B; Prince AM
Studies of virus sterilization of coagulation factor concentrates using marker viruses, AIDS, hepatitis B (HBV) and non-A, non-B hepatitis (NANBHV) viruses indicate the following: Strategies adopted to stabilize coagulation factors to heat denaturation, including addition of high concentrations of solutes or lyophiliz
The need to improve the function of public health services to control sexually transmitted disease (STD) is presented. Improved public health service function in the United Kingdom calls for an improved administrative structure; a 10 year programme of development is envisaged. The thre
Coutinho RA; Schoonhoven FJ; van den Hoek JA; Emsbroek JA
In 1976-8 the incidence of syphilis in Amsterdam doubled from 41 to 88 per 100,000. Contact tracers identified two major risk groups, homosexual men with multiple partners and prostitutes using drugs, and special surveillance programmes for these groups have been organised on a regular basis since 1979. As a result of
Bratzke B; Stadler R; Eichhorn R; Ehlers G; Orfanos CE
Since 1980 a new epidemic form of disseminated mucocutaneous Kaposi s sarcoma (KS) with a progressive clinical course has been observed in populations at risk. Since 1982, 13 cases of AIDS-associated KS have been seen in our department; all of them were in young homosexual males with circulating HIV antibodies and a r
Nine strains of Campylobacter species other than Campylobacter jejuni, Campylobacter coli, and Campylobacter laridis were isolated from patients with acute diarrhea. All nine strains showed preferred growth at 37 degrees C under microaerophilic conditions. Conventional microbiological tests and DNA-DNA dot blotting we
De Dobbeleer G; Godfrine S; Andre J; Ledoux M; De Maubeuge J
The clinically uninvolved skin of 4 patients with well-developed AIDS was investigated by electron microscopy. All biopsy specimens had vascular abnormalities: protruding endothelial cells, vascular channels reduced to slits, gaps within the vascular walls, and extravasated erythrocytes. These features are similar to
This ethnographic study is focused upon the lifestyles of white, suburban, middle-class homosexuals. Interview data on some two dozen individuals obtained in the spring of 1982 was increasingly supplemented and supplanted by continued field observation and other techniques of data-gathering through the summer of 1985.
Moloney murine leukemia virus (M-MuLV) and M-MuLV-derived retroviral vectors are not expressed in early mouse embryos or in embryonal carcinoma cells. M-MuLV-derived mutants or M-MuLV-related variants which transduce the neomycin phosphotransferase gene can, however, induce drug resistance in embryonal carcinoma cells
Nature. 1987 Aug 20-26;328(6132):719-21. Unique Identifier : AIDSLINE MED/87287284
Medley GF; Anderson RM; Cox DR; Billard L
Temporal trends in the prevalence of HIV (human immunodeficiency virus) infection are uncertain because of the reluctance of most governments to embark on large-scale programmes of serological surveillance. In the absence of such data, attempts have been made to relate the number of reported cases of AIDS (acquired im
Differential diagnosis of community-acquired pneumonia can be elusive, even though the disease remains a frequent cause of admission to the hospital. The familiar organisms--pneumococci, group A streptococci, Staphylococcus aureus, Klebsiella pneumoniae, and Hemophilus influenzae--are still often the cause. However, l
In a 1-year period 4 cases of disseminated tuberculosis were seen among homosexual men with HIV infection. In 3 of the cases tuberculosis was the initial manifestation of defective cell mediated immunity. It is concluded that tuberculosis must be considered in any anti-HIV positive patient presenting with fever of unk
Fouret PJ; Touboul JL; Mayaud CM; Akoun GM; Roland J
Pulmonary Kaposi s sarcoma may contribute to respiratory dysfunction in patients with acquired immune deficiency syndrome (AIDS) and features of pneumonitis. Opportunistic infections are readily recognised in endoscopic material, but pulmonary Kaposi s sarcoma is easily missed, so that patients are deprived of specifi
Kaposi s sarcoma of the lung patients with the acquired immune deficiency syndrome is often indistinguishable by clinical and radiographic criteria from opportunistic pneumonia. Pulmonary Kaposi s sarcoma and pneumonia may frequently be present in the same patient. Previous observers have commented on the repeated fai
Brains from 53 autopsied acquired immune deficiency syndrome (AIDS) cases were examined with special attention to microglial nodules and multinucleated giant cells, which are two histological features of AIDS encephalopathy. Twenty-four (45%) of the 53 brains had microglial nodules in varying frequency. Four of these
Using a quantitative classification, we evaluated serial lymph node biopsies in 20 homosexual men with Persistent Generalized Lymphadenopathy (PGL), and correlated the results with peripheral blood lymphocyte counts and clinical findings. In a median follow-up interval of 19 months, ten patients (50%) had progression
Ann Med Interne (Paris). 1987;138(3):202-6. Unique Identifier : AIDSLINE MED/87297086
Pichard E; Grossetete G; Sangare M; Chevallard A; Daumerie D; Rosenheim M
Eleven cases of Kaposi s angiosarcoma (ASK) were observed in Bamako over a 2 year period, representing one third of all malignant cutaneous tumours. There was a clear cut male prevalence. The average age of the patients was 32 years. The commonest sites of involvement were cutaneous, osseous, lymphatic and gastrointes
Ten homozygous sickle cell patients, aged from 4 to 20 years, underwent a periodic red blood cells transfusion program. Indications were = one stroke or more in 4 cases, repeated severe painful crisis in 2 cases, and for others = chronic anaemia induced by hypersplenism, priapism, chronic leg ulceration, dwarfism with
Dev Biol Stand. 1987;67:311-7. Unique Identifier : AIDSLINE MED/87276923
Heinrich D; Sugg U; Brackmann HH; Stephan W; Lissner R
Sterilization of human plasma with beta-propiolactone and UV-irradiation (cold sterilization) has been shown to be effective for a number of common pathogenic viruses. We have published data on the hepatitis safety of cold sterilized factor IX concentrates (PPSB) in healthy volunteers. This study has now been extended
The manufacturing procedures used for the preparation of human plasma proteins that were established before AIDS was first described may reasonably be expected to provide AIDS safe products. Such manufacturing procedures are heat treatment at 60 degrees C in solution for ten hours, described as pasteurization, prepara
Med Hypotheses. 1987 May;23(1):39-42. Unique Identifier : AIDSLINE MED/87286503
Reimund E
Butylated hydroxytoluene (BHT) is a potent inactivator of lipid-enveloped viruses. The viral envelope structure is physically disturbed by BHT, thereby interfering with viral adsorption to host cells. Since the virus responsible for AIDS (HTLV III) contains a lipid envelope, BHT warrants investigation as a potential a
Nature. 1987 Aug 6-12;328(6130):543-7. Unique Identifier : AIDSLINE GENBANK/Y00277
Chakrabarti L; Guyader M; Alizon M; Daniel MD; Desrosiers RC; Tiollais P; Sonigo P
Because of the growing incidence of AIDS (acquired immune deficiency syndrome), the need for studies on animal models is urgent. Infection of chimpanzees with the retroviral agent of human AIDS, the human immunodeficiency virus (HIV), will have only limited usefulness because chimpanzees are in short supply and do not
An inquiry conducted in all the French blood transfusion centres from the 1st of July, 1985 to the 31st of March, 1986 in respect of blood donations confirmed to be positive for anti-HIV antibodies has given the following results: prevalence of 0.59 per thousand (1661/2,809,744); significant difference between first-t
24,982 detections of HIV-antibodies were performed between 1st October 1985 and 31 October 1986, on Reunion Island (550,000 inhabitants) and also on three groups of population: blood donors (23,413), in-patients (505) out-patients (
We conducted 2 experiments to study the effect of heat on the interaction between aminoglycosides and semi-synthetic penicillins in human serum. In one experiment, human serum spiked with either gentamicin or tobramycin at a concentration of 4.7 mg/l plus carbenicillin, ticarcillin, piperacillin, mezlocillin, or azloc
Before 1985 only five cases of the acquired immunodeficiency syndrome (AIDS) had been diagnosed in New Mexico, and there was no information regarding prevalence of antibody to the human immunodeficiency virus (HIV). Of 166 gay and bisexual men tested in 1985 in New Mexico, 20% were found to have antibody to HIV. Of 15
Of 479 homosexual men immunized with three 20-microgram doses of the hepatitis B vaccine, approximately 15% failed to develop protective titers of antibody to the surface antigen of hepatitis B virus (greater than 10 sample ratio units [SRU]). We revaccinated 34 nonresponders with an additional three doses of vaccine
Human immunodeficiency virus (HIV), the etiologic agent of acquired immune deficiency syndrome (AIDS) and AIDS-related complex, has recently been implicated as a factor in the development of AIDS-related neurologic dysfunction and may be responsible for an increasing number of neonatal immunologic and neurologic disor
HTLV-III-like particles were observed within a cell process surrounded by a myelin sheath, in the brain of a 4-year-old boy with AIDS encephalopathy. Similar particles were also observed in the mononuclear macrophage-like cells.
Am J Med. 1987 Aug;83(2):208-12. Unique Identifier : AIDSLINE MED/87296063
Mayer KH; Falk LA; Paul DA; Dawson GJ; Stoddard AM; McCusker J; Saltzman SP; Moon MW; Ferriani R; Groopman JE
A cohort of asymptomatic homosexual men at a Boston community health center was screened for the presence of human immunodeficiency virus (HIV) serum antigen and antibodies to recombinant proteins containing portions of the envelope and the gag (core) gene products. Of 196 asymptomatic men screened, 149 were antigen-n
Roumeliotou-Karayannis A; Tassopoulos N; Karpodini E; Trichopoulou E; Kotsianopoulou M; Papaevangelou G
The prevalence of HBV, HDV and HIV infection was studied in 288 imprisoned intravenous drug addicts (IVDA) and 329 controls. Commercially available radioimmunoassays for the detection of HBV and HDV serologic markers and enzyme-immunoassays for IgM anti-HBc and anti-HIV were used. Anti-HIV positive results were confir
AIDS is a transmissible immunodeficiency syndrome which has first been observed less than a decade ago and since that time has spread in an epidemic manner. Usually it manifests itself by opportunistic infections and/or neoplasias. After courses of a few years, approximately 100% of cases have a lethal outcome. Someti
Thorn RM; Beltz GA; Hung CH; Fallis BF; Winkle S; Cheng KL; Marciani DJ
A unique antigen, CBre3, has been synthesized from a genetically engineered clone to detect human immunodeficiency virus (HIV) env antibodies with high sensitivity and specificity. The antigen contains sequences derived from both envelope proteins of HIV, i.e., gp120 and gp41, and was purified free of Escherichia coli
Acquired immunodeficiency syndrome (AIDS) has become one of the most pressing public health issues of this decade. As a member of the health care team, dental professionals are increasingly confronted with the responsibilities of treating AIDS victims, preventing the transmission of HIV and other infectious agents, an
JAMA. 1987 Aug 14;258(6):785-7. Unique Identifier : AIDSLINE MED/87284245
Fleming DW; Cochi SL; Steece RS; Hull HF
Serum specimens from the cohort of persons who attended sexually transmitted disease clinics in New Mexico during a two-month period were tested for human immunodeficiency virus (HIV) antibody. Twenty-seven (2.0%) of 1374 serum specimens had repeatedly low-positive reactions by enzyme-linked immunosorbent assay testin
JAMA. 1987 Aug 14;258(6):788-90. Unique Identifier : AIDSLINE MED/87284246
Padian N; Marquis L; Francis DP; Anderson RE; Rutherford GW; O'Malley PM; Winkelstein W Jr
Ninety-seven female sexual partners of 93 men infected with human immunodeficiency virus were studied. All of the women had sexual contact within the year before their partner had been diagnosed as having acquired immunodeficiency syndrome or was found to have a positive reaction on the human immunodeficiency virus se
Anson DS; Hock RA; Austen D; Smith KJ; Brownlee GG; Verma IM; Miller AD
Hemophilia B is an X-chromosome-linked bleeding disorder resulting from lack of clotting factor IX activity and affects about 1 in 30,000 males. Current therapy involves injection of crude factor IX prepared from pooled human plasma. Treatment is complicated by viral contaminants in factor IX preparations, such as non
Nature. 1987 Aug 20-26;328(6132):721-3. Unique Identifier : AIDSLINE MED/87287285
Hu SL; Fultz PN; McClure HM; Eichberg JW; Thomas EK; Zarling J; Singhal MC; Kosowski SG; Swenson RB; Anderson DC; et al
Acquired immunodeficiency syndrome (AIDS) is caused by human immunodeficiency virus (HIV) and is now recognized as a worldwide epidemic for which there is no cure or vaccine. Chimpanzees are the only other animals that can be infected by HIV, and therefore the chimpanzee-HIV model system is useful for testing potentia
Oral examinations of 103 consecutive patients with acquired immunodeficiency syndrome (AIDS) were performed. Of these patients, 74 (72%) were heterosexuals and 29 (28%) were homosexual or bisexual men. Lesions that were identified on subsequent examination were recorded separately. Oral candidiasis was the most common
Several classes of oligonucleotide antisense compounds of sequence complementary to the start of the mRNA coding sequence for chloramphenicol acetyl transferase (CAT), including methylphosphonate, alkyltriester, and phosphorothioate analogues of DNA, have been compared to normal phosphodiester oligonucleotides for the
Eighty-seven seropositive subjects with HIV (human immunodeficiency virus) infection together with 20 normal controls with no history of any illness were investigated for the presence of circulating immune complexes (CIC) by the conglutinin binding assay (KgBA) and further studied for isotype characterization of CIC.
Arendrup M; Lindhardt BO; Krogsgaard K; Gaub J; Nielsen JO
In order to elucidate the time when HIV was introduced into a population of patients with acute hepatitis B, serum samples collected in the period 1975-1984 from 331 patients with hepatitis B were analysed for the presence of antibody to HIV (anti-HIV). Anti-HIV was not detected in any of the serum samples from 97 fem
Von Krogh G; Brostrom C; Hermanson J; Von Sydow M; Biberfeld G; Sandstrom E; Bottiger M
Serological tests for hepatitis A (HA) and B (HB), syphilis and HIV were performed on blood samples from 3 groups of homosexual men: 220 and 124 asymptomatic men being investigated in 1978 and 1980 respectively and another 98 men suffering from HA during the winter 1979-80. The two asymptomatic groups revealed similar
A 47-year-old female with acute myeloid leukemia received HIV positive platelets during induction chemotherapy. 18 days later, coincident with the recovery of the bone marrow function, she developed an erythematous rash, mild lymphadenopathy, and nausea which disappeared within 10 days. A week later mild CSF pleocytos
Acta Med Austriaca. 1987;14(1):1-4. Unique Identifier : AIDSLINE MED/87294985
Goebel FD
The acquired immunodeficiency syndrome AIDS is caused by the retrovirus HIV. About 20% develop after the inoculation of the virus an acute clinical picture resembling infectious mononucleosis. Several weeks to months after the infection antibodies can be demonstrated in the serum. Lateron a lymphadenopathy syndrome or
Manca N; di Marzo Veronese F; Ho DD; Gallo RC; Sarngadharan MG
Sera from 51 HTLV-III (human immunodeficiency virus, HIV)-antibody positive subjects consisting of 21 asymptomatic individuals and 15 ARC and 15 AIDS patients were analyzed for their serological profiles toward the viral antigens. One of the asymptomatic subjects only showed a p24 reactivity in the immunoblot, but ant
In addition to immunologic derangement, hematological abnormalities have been reported in the majority of patients with acquired immunodeficiency syndrome (AIDS). In this study 15 patients with AIDS or AIDS-related complex (ARC) were evaluated for the in vitro growth of hemopoietic progenitor cells. In all patients a
McDougal JS; Kennedy MS; Nicholson JK; Spira TJ; Jaffe HW; Kaplan JE; Fishbein DB; O'Malley P; Aloisio CH; Black CM; et al
The titers and isotypes of antibodies to specific proteins of the human immunodeficiency virus were determined by Western blot analysis of sera from 107 homosexual men. Antibody titers were generally lower in sera from patients with the acquired immunodeficiency syndrome (AIDS) and in sera from men whose condition sub
PBL from chimpanzees immunized with a recombinant vaccinia virus that expresses HIV envelope glycoproteins (env), were found to proliferate after stimulation with HIV or with env. Furthermore, CTL clones lytic for autologous target cells expressing HIV envelope glycoproteins were generated after stimulation of the chi
J Med Virol. 1987 Jun;22(2):135-42. Unique Identifier : AIDSLINE MED/87282298
Pezzella M; Pezzella F; Galli C; Macchi B; Verani P; Sorice F; Baroni CD
The presence of human immunodeficiency virus (HIV, or HTLV-III) genome sequence was investigated by means of in situ hybridization in cryostat sections of lymph nodes from lymphadenopathy syndrome (LAS) patients. The technique employed involved the modification of the DNA probe by chemical insertion of an antigenic su
J Med Chem. 1987 Aug;30(8):1270-8. Unique Identifier : AIDSLINE MED/87283685
Herdewijn P; Balzarini J; De Clercq E; Pauwels R; Baba M; Broder S; Vanderhaeghe H
A series of 2 ,3 -unsaturated and 3 -substituted 2 ,3 -dideoxynucleoside analogues of purines and pyrimidines have been synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (HIV). The 2 ,3 -unsaturated analogues of 2 ,3 -dideoxycytidine (ddeCyd) and 2 ,3 -dideoxythymidine (ddeTh
We administered recombinant (biosynthetic) human granulocyte-macrophage colony-stimulating factor (GM-CSF) to 16 patients with the acquired immunodeficiency syndrome (AIDS) and leukopenia (2225 +/- 614 cells per microliter [mean +/- SD]). Each patient first received a single intravenous dose; 48 hours later a 14-day c
Nature. 1987 Aug 6-12;328(6130):539-43. Unique Identifier : AIDSLINE GENBANK/Y00295
Franchini G; Gurgo C; Guo HG; Gallo RC; Collalti E; Fargnoli KA; Hall LF; Wong-Staal F; Reitz MS Jr
The characterization of HIV-1 (HTLV-III/LAV), the human retrovirus associated with AIDS (acquired immune deficiency syndrome) has led to the identification of a group of related human and simian retroviruses which also infect CD4-bearing T lymphocytes. Simian T-lymphotropic virus type III (simian immodeficiency virus)
Schulman S; Biberfeld G; Blomback M; Bottiger B; Egberg N; Johnsson H; Wiechel B
The results of a clinical follow-up of 124 Swedish patients with haemophilia A and B or severe form of von Willebrand s disease are reported, especially with regard to HIV infection and complications thereof. 44 of the patients were anti-HIV positive. In this group there was an increasing prevalence of lymphadenopathy
Science. 1987 Aug 21;237(4817):888-93. Unique Identifier : AIDSLINE GENBANK/K03455
Fisher AG; Ensoli B; Ivanoff L; Chamberlain M; Petteway S; Ratner L; Gallo RC; Wong-Staal F
The genome of the human immunodeficiency virus HIV-1 contains at least eight genes, of which three (sor, R, and 3 orf) have no known function. In this study, the role of the sor gene was examined by constructing a series of proviral genomes of HIV-1 that either lacked the coding sequences for sor or contained point m
Barcellini W; Meroni PL; Frasca D; Sguotti C; Borghi MO; Uberti-Foppa C; Buzzetti P; Lazzarin A; Doria G; Moroni M; et al
The effect of thymopentin treatment on the immune defects in drug addicts with persistent generalized lymphadenopathy and HTLV-III infection was investigated. Thymopentin was administered subcutaneously at two different dose schedules: 50 mg three times a week for 3 weeks (first cycle) and 50 mg/week for 3 months (sec
In 11 non-smoking AIDS patients suspected of pneumocystis carinii pneumonia (PCP), the results of Tc-99m DTPA aerosol clearances, gallium scans, and arterial blood gases were compared with those of bronchoalveolar lavage (BAL). Nine patients had PCP. All had increased clearances five times higher than the normal (5.6
Human blood plasma derived coagulation factor concentrates carry a substantial risk of virus transmission as traditionally prepared. Intensive investigations during the past 5 years have led to the development of several virus sterilization procedures which can be applied to these concentrates as well as to other labi
Immunoblotting ( Western blotting ) is routinely used for detection of antibodies against HIV in the diagnosis of HIV infection. We describe an improved procedure, which does not require virus purification and is easy to control for false-positive results. The technique also does not produce erroneous results due to
Heparinized blood specimens (n = 44) and frozen peripheral blood lymphocyte (PBL) specimens (n = 42) were used to evaluate the effects of lysis on human immunodeficiency virus (HIV) isolation. In the two respective groups, 17 and 27 specimens were HIV antibody positive. In the first group there were 8 and in the secon
Matsui T; Nakashima H; Yoshiyama H; Kobayashi N; Yamamoto N
Cells infected with human immunodeficiency virus (HIV) were selectively stained with peroxidase-coupled antibodies in a recently developed plaque assay for HIV. The numbers of plaques formed with the human T-cell lymphotropic virus type III strain of HIV were exactly the same in stained (immunologically detectable) an
Isolation of Human Immunodeficiency Virus (HIV) was attempted from the tears of seven patients with ARC. For two of these patients the fluid from cell cultures showed significant reverse transcriptase activity. One strain was maintained on C.E.M. (T lymphocytes cell line). Indirect fixed cell immuno fluorescence and W
This article presents varying ideologies regarding homosexuality. The history of homosexual research is reviewed from a clinical and sociological perspective. Centers for research in the area of homosexuality in The Netherlands are described in terms of their area of study as
Neurological complications in the acquired immunodeficiency syndrome (AIDS) are an important aspect of this new infectious disease and occur frequently. The existence of neurotropic variants of the human immunodeficiency virus (HIV), the causative agent of AIDS, is probable. Direct infection of the nervous system with
Nature. 1987 Aug 20-26;328(6132):728-30. Unique Identifier : AIDSLINE MED/87287288
Strebel K; Daugherty D; Clouse K; Cohen D; Folks T; Martin MA
The genome of the human immunodeficiency virus (HIV) contains several open reading frames (ORFs) not present in other viruses. The A gene, also known as Q2 P 3, ORF-1(4) or sor5, partially overlaps the pol gene; its protein product has a relative molecular mass of 23,000 (Mr 23K) and is present in productively infec
Recent changes in social mores have been accompanied by a noted increase in the frequency of sexually transmitted diseases. Viruses that have been identified as causative agents for a large proportion of these diseases have also been associated with various malignant states. Concomitantly, the number of cases of oral
Schweiz Med Wochenschr. 1987 Jun 20;117(25):945-51. Unique Identifier : AIDSLINE MED/87292033
Borradori L; Knellwolf M; Morell A
Interleukin-2, a lymphokine produced by T lymphocytes in response to antigenic or mitogenic stimulation, is necessary for the proliferation and differentiation of various cell populations including activated T lymphocytes, natural killer cells (NK), lymphokine-activated killer cells (LAK), B lymphocytes and macrophage
The AIDS epidemic continues to spread at a rapid rate with a doubling of the number of reported cases every 9 to 12 months. The impact of AIDS in the workplace is just beginning to be felt and the number of disabled workers will increase substantially over the next few years. Employees who have been infected with the
The Acquired Immunodeficiency Syndrome (AIDS), caused by the human immunodeficiency virus (HIV), also called the human T-lymphotropic virus type III/lymphadenopathy-associated virus [HTLV-III/LAV], has affected over 23,000 people; more than half of those with the disease have died. The actual case fatality rate approa
Trans R Soc Trop Med Hyg. 1987;81(2):179-82. Unique Identifier : AIDSLINE MED/87293201
Grange JM
Saprophytic mycobacteria are widely distributed in the environment and contact between them and man is unavoidable. Immunologically effective contact is responsible for cross-reactivity to tuberculin and there is increasing evidence that it also profoundly affects the nature of subsequent responses to BCG vaccination
AIDS and HIV infection have now been recognized as conditions causing immunosuppression associated with an increased risk of mycobacterial disease, caused especially by M. avium complex and M. tuberculosis. In addition, disseminated disease due to other mycobacteria, heretofore considered nonpathogenic, is now being r
Orthotopic liver transplantation was done in 17 patients with fulminant hepatitis. The cause of the liver disease was infection with hepatitis B virus, or co-infection with hepatitis B virus and hepatitis D virus, or infection with hepatitis A virus in 6 patients; drug hepatotoxicity in 5; and indeterminate in 6. Graf
Ann Intern Med. 1987 Sep;107(3):367-82. Unique Identifier : AIDSLINE MED/87297047
Stiehm ER; Ashida E; Kim KS; Winston DJ; Haas A; Gale RP
Intravenous immunoglobulins are stable monomeric pooled human IgG preparations for therapeutic use. Three intravenous immunoglobulins licensed in the United States are generally therapeutically equivalent. Intravenous immunoglobulin is the preferred agent for replacement therapy for mo
Lee ML; Kingdon HS; Hooper J; Courter SG; Holst SL; Piszkiewicz D
A retrospective analysis of 18 patients who had received a human intravenous immunoglobulin (IGIV) preparation was undertaken to ascertain the safety of this preparation with respect to transmission of human immunodeficiency virus (HIV), the virus that causes the acquired immune deficiency syndrome (AIDS). Patients we
We have examined the ability of monocyte-derived macrophages from patients with AIDS and other HIV-related disorders to kill the intracellular pathogen Toxoplasma gondii. We have also examined the capacity of peripheral blood mononuclear cells from these patients to produce macrophage-activating and other lymphokines.
A 32-year-old Haitian male with acquired immunodeficiency syndrome presented with complications of Isospora belli enteritis. Therapy with the investigational drug difluoromethylornithine was initiated. Severe thrombocytopenia, nausea, and vomiting developed during intravenous drug therapy and recurred upon rechallenge
Dev Biol Stand. 1987;67:319-22. Unique Identifier : AIDSLINE MED/87276924
Heldebrant CM; Friedman AE; Fedor EJ
Alpha s Wet Heat-Treatment process is being applied to both Factor VIII (AHF) and Factor IX Complex (PTC). Twelve hemophilia A, five hemophilia B, and one von Willebrands patient have been followed for at least 6 months for evidence of non-A, non-B hepatitis. No ALT elevations were seen in the hemophilia B patients. T
Dev Biol Stand. 1987;67:327-31. Unique Identifier : AIDSLINE MED/87276926
Piszkiewicz D; Kingdon H; Lee ML; Hooper J
Several groups including ours at Hyland have studied the incidence of HTLV-III/LAV seroconversion and non-A, non-B hepatitis (NANBH) in recipients of products made from unscreened plasma. Of 18 previously untreated patients who received heat-treated factor VIII concentrate (HEMOFIL T), none seroconverted for HTLV-III/
Dev Biol Stand. 1987;67:337-51. Unique Identifier : AIDSLINE MED/87276928
Mauler R; Merkle W; Hilfenhaus J
Pasteurization (heat treatment at +60 degrees C for 10 hours in solution) during the production of human plasma protein preparations has proved useful 1. to inactivate a broad spectrum of viruses and 2. in combination with stabilizers to leave the nativity of the products unaffected. Their efficacy has been experiment
Tochikura TS; Nakashima H; Kaneko Y; Kobayashi N; Yamamoto N
The effect of 3 -azido-3 -deoxythymidine ( AZT ) on replication of human immunodeficiency virus (HIV) in various hematopoietic cell lines was investigated. The concentration of AZT required to block HIV replication varied depending on the cell line used
A homosexual youth presented with undiagnosed acute cryptosporidial cholecystitis, a fever of 102.8 degrees F and a WBC of 3500/mm3. This was preceded by several months of watery diarrhea and 20% weight loss. Following cholecystectomy, G-I function was maintained by efficient esophageal aspiration of swallowed air, wi
Interleukin 1 (IL-1) production by freshly isolated and lipopolysaccharide (LPS)-stimulated adherent monocytes-macrophages and IL-2 production by unstimulated and phytohemagglutinin (PHA)-activated T cells were examined in patients with acquired immune deficiency syndr
De Paoli P; Battistin S; Reitano M; Crovatto M; Tirelli U; Diodato S; Santini G
Combinations of monoclonal antibodies defining the OKT 4 positive lymphocyte subset in the peripheral blood of intravenous drug abusers suggest that the 4B4 positive helper inducer population is greatly reduced in subjects infected with HTLV III. No differences were seen instead using different antibodies directed aga
A novel expression system based on coinfection of cells with two recombinant vaccinia viruses has been developed. One recombinant vaccinia virus contained the bacteriophage T7 RNA polymerase gene under control of a vaccinia virus promoter. The second recombinant vaccinia virus contained a target gene of choice flanked
Public Health Rep. 1987 Jul-Aug;102(4):386-91. Unique Identifier : AIDSLINE MED/87290428
Hardy AM; Starcher ET 2d; Morgan WM; Druker J; Kristal A; Day JM; Kelly C; Ewing E; Curran JW
To assess the level of reporting of acquired immunodeficiency syndrome (AIDS) cases, the authors reviewed death certificates for periods of 3 months during July through December 1985 in each of four cities: Washington, DC, New York City, Boston, and Chicago. Since reporting began in 1981, these cities have reported 38
Public Health Rep. 1987 Jul-Aug;102(4):391-4. Unique Identifier : AIDSLINE MED/87290429
Carlson GA; McClellan TA
Intravenous drug abusers in a methadone program in Minnesota were offered HIV-antibody screening to determine the degree of interest in screening and extent of infection. Thirty-nine (85 percent) were willing to be tested. Only seven refused. All patients were aware of acquired immunodeficiency syndrome (AIDS) and the
The number of CD8-positive cells in follicular centres of hyperplastic lymph nodes from 20 Danish and Swedish homosexual men with persistent generalized lymphadenopathy and 43 control patients were enumerated in frozen tissue sections immunostained with monoclonal antibody reactive with the CD8-antigen (cytotoxic-supp
HIV infection induces both immune deficiency and immune stimulation. Central to the pathology of HIV infection is reduction in the numbers and function of CD4 T cells. Impaired functions include decreased proliferation, IL-2 receptor expression and production of lympho
T cells from patients with AIDS-related-complex (ARC) and normal controls were studied for their proliferative response in the autologous mixed lymphocyte reaction (AMLR). Cells from ARC subjects failed to proliferate in autologous MLR compared to normal controls. This defect was not attributable to an altered ratio o
Radvany RM; Schubert MS; Kiamar M; Jarzabek V; Koehler-Carone K; Kuban D; Hecht F
The correlation between lymphocyte proliferative responses to mitogens and T4/T8 ratios was analyzed in a cross section of patients who either were in a high-risk group for HTLV-III infection or fulfilled clinical criteria for acquired immune deficiency syndrome (AIDS). The patient results showed that, correlated with
Twelve neonates in 3 cohorts received blood transfusions from two donors who were infected with human immunodeficiency virus (HIV). All 12 infants developed laboratory and/or clinical evidence of HIV infection, usually in the first year of life. Ten of 12 infants had serum antibody to HIV when tested between 9 and 42
The prevalence of oral colonization with Candida albicans was studied in 225 homosexual men, 99 of whom had HIV antibodies and in 175 heterosexual men. Oral candidal carriage was most prevalent among HIV seropositive homosexual men (77.8%). Rich growth of C. albicans in culture and findings of pseudomycelial elements
Acta Med Austriaca. 1987;14(1):5-9. Unique Identifier : AIDSLINE MED/87294989
Zielinski C
The immunopathogenesis of AIDS and the problems arising from the infection of immunocompetent cells with the human immunodeficiency virus (HIV) are being discussed. Recent investigations point at the fact that CD4-positive T cells are not the only targets of HIV, but that also other cells of the immune system which ar
Ann Intern Med. 1987 Sep;107(3):286-92. Unique Identifier : AIDSLINE MED/87297029
Wittek AE; Phelan MA; Wells MA; Vujcic LK; Epstein JS; Lane HC; Quinnan GV Jr
A sensitive enzyme immunoassay was developed for detecting human immunodeficiency virus (HIV) core antigen. Assay sensitivity was 3.67 pmol/L of purified HIV core protein, and 1 or 100 in-vitro infectious units/mL of HIV in purified virus preparations or cell culture supernatants, respectively. Enzyme immunoassay sens
Twenty-six sera containing anti-HIV antibodies from individuals with AIDS, AIDS-related complex, lymphadenopathy syndrome, or from seropositive individuals without clinical symptoms, were tested for the presence of natural autoantibodies (NAb) to actin, DNA, tubulin, thyroglobulin, albumin, myosin and TNP-BSA. Sera fr
Chieco Bianchi L; Faulkner Valle G; De Rossi A; Dalla Gassa O
A seroepidemiological survey of the Veneto region was undertaken to determine the prevalence of HIV antibodies in the sera of subjects belonging to known risk groups for AIDS and related conditions. The sera were tested by ELISA and confirmed by radioimmunoassay (Western blot). Of the AIDS patients sero-positive for H
The infectious aspects of cancer in humans were epidemiologically pioneered by Dr. David Burkitt through his observations of lymphomatous tumors seen in children in equatorial Africa. Years, later, the Epstein-Barr virus (EBV) was shown to be intimately associated with such tumors and is now recognized as a component
Cytomegalovirus ( CMV ) pneumonitis is a common complication of AIDS. With the development of potentially effective drug therapy, the indications for treatment and best means of diagnosis have become issues of practical importance. We reviewed the clinical records
The long terminal repeats (LTRs) of RNA tumor viruses, including human T-cell lymphotropic virus type I (HTLV-I), contain the control elements for expression of viral genes. Sequence-specific LTR-DNA-binding proteins could regulate viral functions. To search for such proteins we have used an in vitro non-denaturing po
In the past, gallium-67 imaging has undergone several ups and downs related to its clinical importance. After a period of initial enthusiasm, its role and indications are now established. At present, there are two fields of clinical interest for 67Ga-imaging: (1) mediastinal staging in bronchogenic carcinoma and the s
Monoclonal antibodies specific to human T lymphocyte receptors are currently being used to define the biochemical structure of these proteins as well as of functionally distinct cell subsets. Since one of the antibodies (OKT3) recognizing the T3 (CD3) receptor mimics vital physiological processes involved in the activ
Massaia M; Pioppo P; Dianzani U; Guerra MG; Peyretti F; Pileri A; Tamponi G
It has been recently demonstrated that ecto-5 nucleotidase (5 NT) activity is significantly decreased in the peripheral blood lymphocytes (PBL) of homosexual men. This paper reports a study of PBL 5 NT activity in 38 hemophiliacs at risk for the acquired immunodeficiency syndrome (AIDS). The enzyme activity was correl
Dev Biol Stand. 1987;67:233-6. Unique Identifier : AIDSLINE MED/87276912
Martin W
A short review is given on screening tests and regulatory requirements of viral inactivation for plasma products in the Federal Republic of Germany . Guidelines for blood group determination and blood transfusion and guidelines for plasmapheresis contain the particular directions f
Dev Biol Stand. 1987;67:303-10. Unique Identifier : AIDSLINE MED/87276921
Heimburger N; Karges HE; Weidmann E
In a long term surveillance study hemophilia A and B patients were treated with a Factor VIII HS and Factor IX HS concentrate respectively, both pasteurized by heating in solution: 10 hours at 60 degrees C. None of 31 virgin hemophiliacs treated with Factor VIII HS Behringwerke developed hepatitis B during a follow up
Dev Biol Stand. 1987;67:333-6. Unique Identifier : AIDSLINE MED/87276927
Colombo M; Mannucci PM
We carried out safety studies in 45 previously untreated patients with congenital coagulatory defects, who needed to be treated with clotting factor concentrates. Non-A, non-B hepatitis developed in patients who received dry heated F VIII preparations with or without chloroform, but not in those who were infused with
McDonald JA; Caruso L; Karayiannis P; Scully LJ; Harris JR; Forster GE; Thomas HC
In a randomized controlled trial, 41 chronic hepatitis B virus carriers were allocated, by opening numbered computerized randomization envelopes, to receive recombinant interferon-alpha 2A at three different doses: 2.5; 5.0, and 10.0 mU per m2. Thirty-two patients received treatment (6 for 3 months, 26 for 6 months),
Int J Cancer. 1987 Aug 15;40(2):233-9. Unique Identifier : AIDSLINE MED/87278696
Ishikawa K; Fukasawa M; Tsujimoto H; Else JG; Isahakia M; Ubhi NK; Ishida T; Takenaka O; Kawamoto Y; Shotake T; et al
Infection with a simian retrovirus (STLV-I) closely related to human T-lymphotropic virus type I (HTLV-I) was investigated in non-human primates living in their native countries in Africa and Asia. Serum antibodies cross-reacting with HTLV-I antigens were detected in 85 of 567 non-human primates of 30 species. Seropos
Int J Epidemiol. 1987 Jun;16(2):271-6. Unique Identifier : AIDSLINE MED/87278801
Detels R; Visscher BR; Fahey JL; Sever JL; Gravell M; Madden DL; Schwartz K; Dudley JP; English PA; Powers H; et al
One hundred and sixty-seven homosexual men in Los Angeles characterized by HIV antibody, T-cell numbers, titres to cytomegalovirus ( CMV ), and specific sexual practices were followed for two years for immune changes and for mo
Fresh plasma and peripheral blood mononuclear leukocytes were obtained from 11 patients with acquired immunodeficiency syndrome (AIDS). All of these patients were seropositive for antibodies to HTLV-III/LAV and Epstein-Barr virus (EBV). Plasma and uncultured peripheral blood leukocytes from these patients were tested
Hausmann EH; Gelderblom HR; Clapham PR; Pauli G; Weiss RA
Human antisera positive for HIV were evaluated on HTLV-IIIB producing cells by two different immunoelectron microscopic (IEM) techniques. In preembedding immunoferritin IEM a heavy label was observed with early budding HIV. Under the same conditions cell released mature particles were almost negative, which could be
Human T lymphotropic virus type I (HTLV-I) is an exogenous RNA tumor virus etiologically linked to adult T cell leukemia and related diseases. In this paper, we describe that two 2 ,3 -dideoxynucleoside analogues, erythro 3 -azido-2 ,3 -dideoxythymidine (also called azidothymidine) and 2 ,3 -dideoxycytidine can inhibi
Ninety analogues of suramin have been examined for their ability to inhibit the exogenous reverse transcriptase (RT) of human immunodeficiency virus type I (HIV-I). Of these compounds, 57 inhibited the poly(rC).oligo(dG)-dependent RT activity. Three classes of dose-response curves could be discriminated. Allocation of
J Med Virol. 1987 Jun;22(2):157-62. Unique Identifier : AIDSLINE MED/87282300
Farthing C; Anderson MG; Ellis ME; Gazzard BG; Chanas AC
Foscarnet was administered to eight AIDS patients for suspected cytomegalovirus ( CMV ) pneumonitis as a continuous intravenous infusion for a minimum of 8 days. All the patients improved, three showing complete resolution of s
Culver KW; Ammann AJ; Partridge JC; Wong DF; Wara DW; Cowan MJ
To evaluate the possible effects of maternal intravenous drug use on infant immunity, we measured the in vitro peripheral blood mononuclear cell proliferative responses to phytohemagglutinin (PHA) and pokeweed mitogen, T cell subset numbers, immunoglobulin levels, and titers of antibodies to
JAMA. 1987 Aug 14;258(6):814-21. Unique Identifier : AIDSLINE MED/87284253
Horsburgh CR Jr; Douglas JM; LaForce FM
This study provides the background recommendations of the US Preventive Services Task Force for interventions by primary care physicians to prevent sexually transmitted diseases. Rationale for and data supporting use of barrier methods, epidemiologic treatment, contact tracing, patient education, prophylactic antibiot
Med Hypotheses. 1987 Jul;23(3):303-7. Unique Identifier : AIDSLINE MED/87286532
Ludwig DS; Schoolnik GK
Two obstacles hinder the development of an AIDS vaccine: (1) the AIDS virus exhibits extensive amino acid heterogeneity between isolates and (2) antibodies elicited by virus during the course of natural infection are often non-neutralizing. A vaccine designed to induce anti-idiotypic antibodies against the virus rece
Med Microbiol Immunol (Berl). 1987;176(4):189-98. Unique Identifier : AIDSLINE MED/87286638
Nakashima H; Harada S; Yamamoto N
The inhibitory effect of all-trans-retinoic acid (RA) on human immunodeficiency virus (HIV) replication upon infection was studied quantitatively using a novel bioassay system with a HTLV-I-carrying human T-cell line, MT-4. The results can be summarized as follows. The appearance of HIV antigen was significantly reduc
Nature. 1987 Aug 6-12;328(6130):548-50. Unique Identifier : AIDSLINE GENBANK/X05821
Arya SK; Beaver B; Jagodzinski L; Ensoli B; Kanki PJ; Albert J; Fenyo EM; Biberfeld G; Zagury JF; Laure F; et al
New human retroviruses antigenically related to HIV and even more closely to STLV-III have been recently isolated from individuals from some West African countries. One of these viruses, HTLV-IVP, was reportedly isolated from lymphocytes of a healthy female prostitute. Another isolate, LAV-2FG, was obtained from an AI
Proc Natl Acad Sci U S A. 1987 Aug;84(16):5893-7. Unique Identifier : AIDSLINE MED/87289708
Thiel HJ; Schwarz H; Fischinger P; Bolognesi D; Schafer W
Previous studies have demonstrated that the onset of AKR leukemia could be dramatically delayed and the overall incidence significantly reduced following treatment with high-titered heterologous antibodies directed against the gp71 major glycoprotein of the virus. However, to be maximally successful, the treatment had
Dalakas MC; Gravell M; London WT; Cunningham G; Sever JL
Eleven of 25 rhesus monkeys which died of simian acquired immunodeficiency syndrome (SAIDS) caused by infection with a type D retrovirus related to Mason- Pfizer monkey virus showed evidence of muscle weakness and atrophy and had elevated levels of muscle enzymes. Biopsies
Science. 1987 Aug 28;237(4818):1047-51. Unique Identifier : AIDSLINE MED/87292136
Lee MR; Ho DD; Gurney ME
Dementia is common in patients with AIDS, but the mechanism by which the human immunodeficiency virus type 1 (HIV-1) causes the neurological impairment is unknown. In this study the possibility that an antigen of HIV-1 suppresses neuronal responses to neurotrophic factors was examined. Both HIV-1 and a related retrovi
Tijdschr Diergeneeskd. 1987 Jun 15;112(12):726-37. Unique Identifier : AIDSLINE MED/87292906
Weijer K; UytdeHaag F; Osterhaus AD
Feline leukaemia virus (FeLV) usually occurs in its natural species, the domestic cat. FeLV is also important to human individuals as a comparative model, as FeLV may cause a variety of diseases which are partly malignant and partly benign, such as immunosuppression which bears a resemblance to AIDS (acquired immune d
A lymph node of a patient with AIDS-related complex was studied with light and electron microscopic techniques. In numerous plasma cells and follicular center cells amorphous and unusual crystalline structures which probably consist of abnormal immunoglobulin could be found.
Georgsson G; Houwers DJ; Stefansson K; Palsson PA; Petursson G
Several monoclonal antibodies to different epitopes of the two major core proteins of visna virus, p25 and p15, were tested with the Avidin-Biotin immunostaining method on formaldehyde-fixed and paraffin-embedded sections of brains from patients with acquired immune deficiency syndrome (AIDS) who had shown neurologica
Am J Med. 1987 Aug;83(2):201-7. Unique Identifier : AIDSLINE MED/87296062
Laskin OL; Cederberg DM; Mills J; Eron LJ; Mildvan D; Spector SA
Ganciclovir is a congener of acyclovir with in vitro activity against cytomegalovirus . Ninety-seven patients with the acquired immune deficiency syndrome (AIDS) and a serious cytomegalovirus infection received ganciclovir, 3.0 to 15 mg/kg per
Pedersen M; Permin H; Jensen C; Stahl Skov P; Norn S; Faber V
Type I allergy against some common microorganisms was investigated in 14 patients with AIDS and 11 human immunodeficiency virus (HIV) antibody-positive homosexual men, and in a control group consisting of 13 heterosexual men without HIV antibodies. Basophil histamine release technique was used as a sensitive method to
Ann Intern Med. 1987 Sep;107(3):383-91. Unique Identifier : AIDSLINE MED/87297048
Gabuzda DH; Hirsch MS
Subacute encephalitis caused by infection of the central nervous system by the human immunodeficiency virus (HIV) is the most frequent cause of neurologic dysfunction in patients with the acquired immunodeficiency syndrome (AIDS). This disorder results in progressive cognitive, motor, and behavioral abnormalities in a
It is generally accepted that human immunodeficiency virus (HIV) is the etiologic agent of the acquired immunodeficiency syndrome and related diseases. In this report, we demonstrate the antiviral effect of nucleoside analogs 2 ,3 -didehydro-2 ,3 -dideoxythymidine (DHT) and 2 ,3 -didehydro-2 ,3 -dideoxycytidine (DHC)
Hadderingh RJ; Tange RA; Danner SA; Eeftinck Schattenkerk JK
Patients with acquired immunodeficiency syndrome (AIDS) frequently show signs and symptoms involving the head and neck. We reviewed the clinical histories of 63 cases with AIDS, with patients treated from 1982 to December 1985, in our hospital. Findings referable to the head and neck were seen in 43 patients. Comparis
Aboud M; Golde DW; Bersch N; Rosenblatt JD; Chen IS
We report here the development of a rapid and quantitative method for measuring in vitro T cell transformation by human T cell leukemia viruses type I (HTLV-I) and type II (HTLV-II). This method is based on our finding that cocultivation of lethally irradiated HTLV-producing cells with peripheral blood lymphocytes (PB
Cao YZ; Valentine F; Hojvat S; Allain JP; Rubinstein P; Mirabile M; Czelusniak S; Leuther M; Baker L; Friedman-Kien AE
The sera of well-characterized populations were examined for three markers of human immunodeficiency virus (HIV) infection; HIV antigen (HIV Ag), and antibodies to HIV envelope (gp41) and core (p24) proteins. Of 563 serum samples tested, 251 were from HIV-infected patients diagnosed as having AIDS manifested by opport
Stepina VN; Gurtsevich VE; Morozova LF; Etkin AF; Urazova LN
Patients with various forms of hemoblastoses (328) and clinically healthy persons (530) were examined for antibodies to HTLV-I. The presence of antibodies was detected in 3 out of 40 patients with acute lymphoblastic leukemia and only in 1 of 70 patients with lymphosarcoma. These data indicate that sporadic cases of T
Maekawa I; Yosida K; Hirasawa K; Mayumi T; Kanda M
An autopsy case of smoldering adult T-cell leukemia (ATL) is presented. 67 year-old woman was admitted to our hospital with complaints of fever, cough and increasing dyspnea on October 2, 1985. Laboratory findings revealed high LDH, azothermia and slightly leukocytosis with low percentage of flower cells. CRP was stro
Int J Cancer. 1987 Aug 15;40(2):145-8. Unique Identifier : AIDSLINE MED/87278680
Nakada K; Yamaguchi K; Furugen S; Nakasone T; Nakasone K; Oshiro Y; Kohakura M; Hinuma Y; Seiki M; Yoshida M; et al
The relationship between strongyloidiasis and HTLV-I was investigated in Okinawa, an area where both conditions are endemic. Thirty-six patients with strongyloidiasis were seropositive for HTLV-I and suffered from several related clinical complications. Fourteen of these patients (39%) were shown to have monoclonal in
Several species of small animals were inoculated at birth or as adults with blood components from patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related disorders, or with the human immunodeficiency virus (HIV). No ill effects were noted in rats, hamsters, guinea-pigs, rabbits or musk shrews. Mice in
Tamura K; Makino S; Araki Y; Seita M; Aratake Y; Ohtaki S; Sagawa K; Miwa M
The leukemic cells of adult T-cell leukemia (ATL) usually express the helper/inducer associated antigen reactive with anti-CD4 antibodies but not with anti-CD8. We present a 63-yr-old woman with ATL characterized by circulating leukemic cells with CD4+/CD8- phenotype, hepatosplenomegaly with no lymphadenopathy, and th
To understand the mechanism of HIV-mediated neuropathology five viral isolates were obtained from four AIDS cases with central nervous system manifestations as the primary involvement. The isolates were identified as HIVs by antigenic cross-reactivity and nucleic acid hybridizations to HIV-specific antibodies and DNA
Med Hypotheses. 1987 May;23(1):33-8. Unique Identifier : AIDSLINE MED/87286502
Sudan BJ
There is evidence in some individuals that seborrhoeic dermatitis is an immuno-allergic reaction induced by nicotine as hapten. Nicotine is present in passive smoking, botanic areas, some foods at very low levels, smokeless tobacco and chewing gums. The successful use of topical ketoconazole as an anti-fungal treatmen
Austin CB; Young JW; Park HJ; Needleman BW; Handwerger BS; Rosenbaum RC
Adult T-cell leukemia/lymphoma is a relatively uncommon disease, most often found in Japan , the Caribbean, the southeastern United States , and South America. To date there have been few reports of its skeletal manifestations. A case is reported in a
Gan To Kagaku Ryoho. 1987 Aug;14(8):2411-6. Unique Identifier : AIDSLINE MED/87297562
Osame M; Igata A; Matsumoto M; Tara M
Following our proposal of a new clinical entity, HTLV-I-associated myelopathy (HAM), at least 270 cases have now been diagnosed in Japan . The geographical distribution resembles that of adult T-cell leukemia-lymphoma. Our laboratory has now identified 85 cases (27 males and 58 femal
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