SIMIAN RETROVIRUS NLM AIDSLINE Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

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SIMIAN RETROVIRUS

Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 145-53, 1986.. Unique Identifier : AIDSLINE ICDB/87629272
Desrosiers R; New England Region Primate Res. Center, Southborough, MA

Abstract: Type D retrovirus has been readily isolated from macaques that had a spontaneous immunodeficiency syndrome; however, experimental infection of naive macaques with D/New England has not induced the immunodeficiency syndrome. Sufficient numbers of Macaca cyclopis are not available to determine whether they are more susceptible to disease induction by type D retrovirus; also, the extent of type D retrovirus in the New England Region Primate Research Center (NERPRC) macaque colony is yet unknown. If infection were confined primarily to the disease population, this would provide strong evidence for a causative role of type D retrovirus in disease. If, however, the rate of infection in the colony is high, as with cytomegalovirus, it would not be surprising to recover the virus with high frequency from immunodeficient animals. Type D retrovirus could play an important role in the pathogenesis of the disease without being primarily responsible for the immunodeficiency. Serologic screening has provided evidence for prior infection with a human T cell lymphotropic virus (HTLV)-related virus among at least some NERPRC macaques with lymphoproliferative and immunodeficiency disorders. (6 Refs)
Keywords: Acquired Immunodeficiency Syndrome/MICROBIOLOGY/*VETERINARY Animal Base Composition Cloning, Molecular DNA, Viral Genes, Viral Macaca Monkey Diseases/*MICROBIOLOGY Nucleic Acid Hybridization Retroviridae/GENETICS/*ISOLATION & PURIF MONOGRAPH

KWDacquiredimmunodeficiencysyndrome/microbiology/KWDveterinaryanimalbasecompositioncloning,moleculardna,viralgenes,viralmacacamonkeydiseases/KWDmicrobiologynucleicacidhybridizationretroviridae/genetics/KWDisolation&purifmonograph
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Copyright © 1987 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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