Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.
STUDIES IN NONHUMAN PRIMATES ON RETROVIRUSES ASSOCIATED WITH AN ACQUIRED IMMUNE DEFICIENCY SYNDROME
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 233-7, 1986.. Unique Identifier : AIDSLINE ICDB/87629279 van Es AA; van Vreeswijk W; Lowenstine LJ; Bentvelzen P; Primate Center TNO, Rijswijk, The Netherlands
Abstract:
In 1982 at the Dutch Primate Center, chimpanzees and rhesus monkeys were inoculated with blood from one of the first AIDS patients in the Netherlands. Only the chimpanzees proved to replicate the retrovirus as demonstrated by the presence of antibodies and by the presence of a provirus in some leukocytes. When, in a collaborative program with Montagnier at the Institut Pasteur, lymphocytes of chimpanzees and rhesus monkeys were infected in vitro with so-called lymphadenopathy-associated virus (LAV), the cells of all of the tested chimpanzees proved to replicate the LAV at a high rate, while cells of only 3/10 tested rhesus monkeys proved to be positive. When infected cells were inoculated back into the donors and the animals were thereafter inoculated five times with purified LAV, the chimpanzees proved to be infected within 1 mo, whereas the rhesus monkeys remained negative in various tests during an observation period of 1 yr. A serological survey of 100 chimpanzees kept in the Dutch Primate Center revealed four additional positives for antibodies to LAV; it was considered to be unlikely that this seropositivity was due to sexual contact with the intentionally infected chimpanzees. In additional studies, a relationship between susceptibility to the pathogenic action of the simian AIDS (SAIDS) agent and the RhLA system was investigated (the RhLA system is comparable to the human HLA and murine H-2 systems). The RhLA complex comprises A and B regions coding for classical, serologically defined antigens present on B and T cells and various other tissues; the D/DR gene codes for antigens involved in mixed lymphocyte culture stimulation. Fifteen unrelated rhesus monkeys were typed for the DR locus in addition to the other RhLA loci and then inoculated with homogenized tissues from monkeys with SAIDS. Seven of the animals carried the DR-1-RhLA antigen; six of these animals developed SAIDS. Two diseased animals carried the DR-2 antigen. Only one of the seven resistant monkeys carried DR-1. The excess of DR-1 in the group of affected animals suggests strongly that this allele causes susceptibility to the SAIDS virus. (13 Refs)
Keywords: Acquired Immunodeficiency Syndrome/MICROBIOLOGY/VETERINARY Animal Chimpansee troglodytes/*MICROBIOLOGY HIV/PHYSIOLOGY Macaca mulatta/*MICROBIOLOGY Major Histocompatibility Complex Retroviridae/*PHYSIOLOGY Virus Replication MONOGRAPH
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Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.
