Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.
ASSOCIATION OF RETROPERITONEAL FIBROMATOSIS WITH TYPE D RETROVIRUSES
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 335-53, 1986.. Unique Identifier : AIDSLINE ICDB/87629286 Benveniste RE; Stromberg K; Morton WR; Tsai CC; Giddens WE Jr; Lab. of Viral Carcinogenesis, NCI, Frederick Cancer Res.; Facility, Frederick, MD
Abstract:
In the introduction to this chapter, all known endogenous and infectious primate retroviruses are listed in a table, characteristics of endogenous retroviruses are given in a second table, and properties of infectious retroviruses are given in a third. This report focuses on the infectious type D retroviruses that have been isolated at the University of Washington primate center and on their association with disease in that colony. The association of retroperitoneal fibromatosis (RF) with type D retroviruses is discussed under the following headings: disease at the Washington Primate Research Center (WPRC), inoculation of macaques with RF tissues, isolation and characterization of type D retroviruses from the WPRC, profile origin of retrovirus-D/Washington (R-D/W), association of RF and retrovirus isolation at the WPRC, and characterization of type D isolates isolated at various primate centers. At the WPRC, the type D retrovirus present in the colony is strongly associated with RF. In addition, the ability to cause RF by inoculation of macaques with biologically cloned virus suggests that this retrovirus may be responsible for RF in macaques. The type D retrovirus isolates from the California colony are associated with an acute form of immunosuppressive disease and mortality, whereas the isolates from the New England primate center are more often associated with a transient lymphadenopathy and a decrease in lymphocyte blastogenic responsiveness; no cases of RF have been obtained after inoculation of macaques with viruses from either of these two primate colonies. The WPRC isolates, on the other hand, which have been shown to transform various rodent fibroblast cell lines in vitro, are strongly associated with RF. Their role in immunosuppression has not been clearly established. These three different isolates, which are molecularly distinct, are thus associated with different pathogenicities in vivo. (37 Refs)
Keywords: Animal Fibroma/ETIOLOGY/MICROBIOLOGY/*VETERINARY Immunologic Deficiency Syndromes/VETERINARY Macaca Monkey Diseases/*MICROBIOLOGY Nucleic Acid Hybridization Retroperitoneal Neoplasms/ETIOLOGY/MICROBIOLOGY/*VETERINARY Retroviridae/*ISOLATION & PURIF Retroviridae Proteins/ANALYSIS Sequence Homology, Nucleic Acid Virus Replication MONOGRAPH
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Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.
