ABNORMALITIES OF HUMORAL IMMUNITY RESULTING FROM IMMUNOREGULATORY T-CELL DYSFUNCTION

Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

ABNORMALITIES OF HUMORAL IMMUNITY RESULTING FROM IMMUNOREGULATORY T-CELL DYSFUNCTION

Serono Symp Publ Raven Press; 28:233-43 1986. Unique Identifier : AIDSLINE ICDB/87630115
Gelfand EW; Dosch HM; Div. of Immunology/Rheumatology, Research Inst., The Hospital for; Sick Children, 555 University Ave., Toronto, Ontario M5G 1X8,; Canada

Abstract: Examples of human diseases that are characterized by abnormal immunoglobulin production and that appear to involve excessive or deficient T-helper and T-suppressor cell activities are discussed in this review. Among the primary disorders, diseases related to failure of T-cell help include abnormalities of blocks of T-cell differentiation (eg, severe combined immunodeficiency disease), transient hypogammaglobulinemia of infancy, and congenital or common variable immunodeficiency. No primary disorders related to excess T-cell help were known to the authors. Primary disorders related to absence or failure of T-suppressor activity include nucleoside phosphorylase deficiency and atopic dermatitis. Primary disorders related to absence or failure of T-suppressor cell activity include common variable and congenital hypo- or agammaglobulinemia, selective deficiency of IgA, and cord blood. Among the secondary disorders, diseases or treatments related to failure of T-cell help include acquired immunodeficiency syndrome, post bone marrow transplant, and certain drugs. Mucocutaneous lymph node syndrome (Kawasaki's disease) represents a secondary disorder related to excess T-cell help. Secondary disorders related to absence of T-suppressor cell activity include several autoimmune diseases (eg, multiple sclerosis, lupus erythematosus, and myasthenia gravis). Secondary disorders or treatments related to excess T-suppressor cell activity include graft-versus-host disease, infectious mononucleosis, and drugs. (36 Refs)

Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY Agammaglobulinemia/IMMUNOLOGY *Antibody Formation Autoantibodies/ANALYSIS Autoimmune Diseases/IMMUNOLOGY B-Lymphocytes/IMMUNOLOGY Cell Differentiation Human Hypergammaglobulinemia/IMMUNOLOGY Immunoglobulins/*METABOLISM Immunologic Deficiency Syndromes/*IMMUNOLOGY Lymphocyte Transformation Myasthenia Gravis/IMMUNOLOGY Plasma Cells/IMMUNOLOGY T-Lymphocytes/*IMMUNOLOGY T-Lymphocytes, Helper-Inducer/IMMUNOLOGY T-Lymphocytes, Suppressor-Effector/IMMUNOLOGY MEETING PAPER

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