Dev Oncol; 32:245-50 1985. Unique Identifier : AIDSLINE ICDB/87629333
Longo DL; Steis RG; Masur H; Lane HC; Preble O; Fauci AS; Gelmann EP; Medicine Branch, NCI, Bethesda, MD
The acquired immune deficiency syndrome (AIDS), an almost uniformly fatal, transmissible new disease characterized by profoundly depressed cellular immunity, is manifest clinically by serious, life-threatening opportunistic infections and neoplasms. There are four major risk groups: male homosexuals and bisexuals (71%
Dev Oncol; 32:261-7 1985. Unique Identifier : AIDSLINE ICDB/87629335
Riggs SA; Kalter S; Cabanillas F; Hagemeister FB; Velasquez WS; Barlogie B; Salvador P; Mansell P; Hersh E; Butler J; Dept. of Hematology, Univ. of Texas M.D. Anderson Hosp. and Tumor; Inst., Houston, TX
Unusual presentations of non-Hodgkin s lymphomas were studied in 15 homosexual males with non-Hodgkin s lymphoma: 5 had diffuse large cell lymphoma (DLC), 6 had diffuse undifferentiated lymphoma (DUL) of either the Burkitt s or non-Burkitt s type, 1 had unclassifiable lymphoma, 1 had well-differentiated lymphocytic ly
The purpose of this study was to learn more about the psychological status of people with life-threatening illnesses by assessing self-esteem, locus of control, depression, anxiety, and distress. Four groups of men, ages 25-50, participated in this study. Patients with acute leukemia (a non-contagious life-threatening
Cellular and Molecular Biology of Lymphokines. Sorg C, Schimpl A, eds. New York, Academic Press Inc., p. 755-9, 1985.. Unique Identifier : AIDSLINE ICDB/87632377
Welte K; Kolitz JE; Merluzzi VJ; Flomenberg N; Engert A; Miller GA; Holloway K; Sykora KW; Venuta S; O'Reilly RJ; et al; Lab. of Developmental Hematopoiesis, Memorial Sloan-Kettering; Cancer Center, New York, NY 10021
Results obtained to date on endogenous lymphocyte interleukin 2 (IL2) production and proliferation in the presence or absence of exogenous IL2 in patients (pts) with primary and acquired immunodeficiency are reported, as are preliminary results of Phase I clinical trials. OKT3 stimulation in vitro of peripheral blood
Hahn BH; Shaw GM; Wong-Staal F; Gallo RC; Lab. of Tumor Cell Biology, Div. of Cancer Treatment, NCI,; Bethesda, MD 20205
A novel human retrovirus, HTLV-III/LAV, with T-lymphotropic and cytopathic properties has been identified as the causative agent of the acquired immunodeficiency syndrome (AIDS). A body of evidence relevant to the issue of genome variation of HTLV-III/LAV is summarized. To define the nature and spectrum of variation a
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 3-13, 1986.. Unique Identifier : AIDSLINE ICDB/87629263
Salzman LA; Sell KW; Office of the Scientific Director, Natl. Inst. of Allergy and; Infectious Diseases, Bethesda, MD
The acquired immune deficiency syndrome (AIDS) has become a prime focus of study, classified by the Public Health Service as the number one infectious disease target because the disease is of enormous, increasing proportions. Its threat to the blood and blood product supply is now under increasing control with the use
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 145-53, 1986.. Unique Identifier : AIDSLINE ICDB/87629272
Desrosiers R; New England Region Primate Res. Center, Southborough, MA
Type D retrovirus has been readily isolated from macaques that had a spontaneous immunodeficiency syndrome; however, experimental infection of naive macaques with D/New England has not induced the immunodeficiency syndrome. Sufficient numbers of Macaca cyclopis are not available to determine whether they are more susc
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 193-202, 1986.. Unique Identifier : AIDSLINE ICDB/87629276
Yetter RA; Hartley JW; Fredrickson TN; Morse HC III; Lab. of Immunopathology, Natl. Inst. of Allergy and Infectious; Diseases, NIH, Bethesda, MD
Abnormalities that are induced in mice by murine leukemia viruses (MuLVs) are the result of integrations of the viruses into the genomes of the mice. These integrations may take place in either the germ cell or the somatic cell. Pathogenic mechanisms in MuLV systems are briefly reviewed at the beginning of this chapte
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 233-7, 1986.. Unique Identifier : AIDSLINE ICDB/87629279
van Es AA; van Vreeswijk W; Lowenstine LJ; Bentvelzen P; Primate Center TNO, Rijswijk, The Netherlands
In 1982 at the Dutch Primate Center, chimpanzees and rhesus monkeys were inoculated with blood from one of the first AIDS patients in the Netherlands . Only the chimpanzees proved to replicate the retrovirus as demonstrated by the presence of antibodies and by the presence of a
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 241-64, 1986.. Unique Identifier : AIDSLINE ICDB/87629280
Shannon WM; Kettering-Meyer Lab., Southern Res. Inst., Birmingham, AL
The prospects for chemotherapeutic intervention and possibly even chemoprophylaxis in the control of acquired immune deficiency syndrome (AIDS) virus infection are discussed. Most of the research efforts in antiviral chemotherapy in recent yr have been directed toward the herpes viruses. The chemical structures of sel
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 279-84, 1986.. Unique Identifier : AIDSLINE ICDB/87629282
Morrison RP; Nishio J; Chesebro B; Lab. of Persistent Viral Diseases, Rocky Mountain Lab., Natl.; Inst. of Allergy and Infectious Diseases, NIH, Hamilton, MT
Infection by oncogenic retroviruses is frequently associated with immunosuppression. In the case of the erythroleukemia-inducing Friend murine leukemia virus complex (FV), suppression of functions of B lymphocytes, T lymphocytes, and macrophages has been observed in infected and leukemic mice; however, some mouse stra
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 335-53, 1986.. Unique Identifier : AIDSLINE ICDB/87629286
Benveniste RE; Stromberg K; Morton WR; Tsai CC; Giddens WE Jr; Lab. of Viral Carcinogenesis, NCI, Frederick Cancer Res.; Facility, Frederick, MD
In the introduction to this chapter, all known endogenous and infectious primate retroviruses are listed in a table, characteristics of endogenous retroviruses are given in a second table, and properties of infectious retroviruses are given in a third. This report focuses on the infectious type D retroviruses that hav
Aiuti F; Paganelli R; Ensoli B; Cabello A; Cherchi M; Venuta S; Capobianchi MR; Dianzani F; Dept. of Clinical Immunology, Univ. of Rome, 'La Sapienza,' Rome,; Italy
The presence of interleukin-2 ( IL-2 ) and gamma-interferon (gamma IFN) was measured by conventional tests after mitogen stimulation of peripheral blood mononuclear cells (PBMCs) of patients who had immunodeficiencies and severely defective T lymphocyte functions in vivo
Gelfand EW; Dosch HM; Div. of Immunology/Rheumatology, Research Inst., The Hospital for; Sick Children, 555 University Ave., Toronto, Ontario M5G 1X8,; Canada
Examples of human diseases that are characterized by abnormal immunoglobulin production and that appear to involve excessive or deficient T-helper and T-suppressor cell activities are discussed in this review. Among the primary disorders, diseases related to failure of T-cell help include abnormalities of blocks of T-
Margolick JB; Bowen DL; Lane HC; Fauci AS; Lab. of Immunoregulation, National Inst. of Allergy and; Infectious Disease, NIH, Bethesda, MD 20205
The cellular immune system (ie, T cell function) constitutes the function that is primarily affected in acquired immunodeficiency syndrome (AIDS), but functional abnormalities of B cells, mononuclear phagocytes, and natural killer cells also have been described. The immunological abnormalities in AIDS are discussed in
Abstracts are presented from the UCLA symposium on Viruses and Human Cancer, held February 2-9, 1986, in Park City, UT. Plenary sessions discussed biology of human T lymphotropic retroviruses, molecular biology of human T lymphotropic viruses, human papilloma viruses, human hepatitis virus, Epstein-Barr virus, and pre
Monocyte function in rhesus monkeys with simian acquired immune deficiency syndrome (SAIDS) was compared with that in age-matched normal juvenile rhesus monkeys. The functional tests were (1) chemotaxis, (2) phagocytosis of opsonized Candida albicans, (3) killing and/or growth inhibition of Candida albicans, (4) gener
Moulton JM; California School of Professional Psychology, Berkeley
The psychological adjustment to a diagnosis of Acquired Immune Deficiency Syndrome (AIDS) and related conditions (ARC) was examined in 37 gay men. Five areas were investigated: (1) the type of causal attributions for health problems used by persons with AIDS or ARC in their search for meaning in the diagnosis and cour
Charles KA; California School of Professional Psychology, Berkeley
This research attempted to apply health psychology principles to primary prevention of Acquired Immune Deficiency Syndrome (AIDS). Primary prevention among gay men, the group currently at greatest risk for AIDS, involves efforts to change sexual behaviors associated with virus transmission. Prior psychological researc
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 431-40, 1986.. Unique Identifier : AIDSLINE ICDB/87629292
Gardner MB; Dept. of Pathology, Sch. of Medicine, Univ. of California, Davis,; CA
Retrovirus history is reviewed; simian acquired immune deficiency syndrome (SAIDS) and human acquired immune deficiency syndrome (AIDS) are discussed and their similarities and differences are compared; AIDS viruses are compared; and, finally, the AIDS vaccine rationale is addressed. SAIDS, an AIDS-like disease in mon
The author and other investigators have utilized rearrangements of immunoglobulin genes as DNA level clonal markers for neoplasms of B-cell lineage. All B-cell malignancies of mature phenotype had clonally rearranged heavy and light chain immunoglobulin genes, whereas the human T-cell neoplasms uniformly retained germ
Human T cell leukemia (lymphotropic) virus type III (HTLV-III) belongs to a group of human retroviruses including HTLV-I, the cause of adult T-cell leukemia/lymphoma, and HTLV-II, which was isolated from a cell line established from a patient with a variant of hairy cell leukemia. Evidence implicating HTLV-III as the
Ebbesen P; Melbye M; Biggar RJ; The Inst. of Cancer Research, Danish Cancer Society,; Radiumstationen DK-8000 Aarhus C, Denmark
Danes have the highest incidence of acquired immunodeficiency syndrome (AIDS) among the indigenous populations of Europe. Aspects of a series of previously published studies on Danes, which may have some general relevance, are discussed. In 1982, a very strong statistical correlation between sexual contact with US cit
Carbonari M; Scarpati B; Scano G; Turbessi G; Lanzalone C; Luzi G; Bonomo R; Giordano F; Aiuti F; Dept. of Allergy and Clinical Immunology, Univ. of Rome 'La; Sapienza,' Rome, Italy
An update is reported on the prevalence of specific antibodies to human T lymphotropic retrovirus type III/lymphoadenopathy-associated virus (HTLV-III/LAV) in patients with acquired immunodeficiency syndrome (AIDS), in patients with AIDS-related complex (ARC), in subjects at risk for AIDS, and in individuals having se
Health Policy. 1987 Feb;7(1):13-9. Unique Identifier : AIDSLINE AHA/87108951
Gevers JK
Like other serious infectious diseases, AIDS gives rise to a fundamental conflict between personal rights and public health. The recently developed test to detect antibody to the viral agent for AIDS is now predominantly being used to screen blood donors but it may spread to other settings. The possibility to demonstr
Cancer. 1987 Feb 15;59(4):807-10. Unique Identifier : AIDSLINE MED/87102514
Hamm PG; Judson MA; Aranda CP
Fiberoptic bronchoscopy is a major tool in the diagnostic evaluation of pulmonary disease in patients with the Acquired Immune Deficiency Syndrome. Multiple opportunistic infections and Kaposi s sarcoma affect the lung in this disorder. In contrast to opportunistic infections, Kaposi s sarcoma is rarely reported to be
Recent reports have described an increase in cases of tuberculosis in several urban centers. To investigate the possible relationship between tuberculosis and the acquired immunodeficiency syndrome (AIDS), we reviewed case records at a New York City hospital between 1978 and 1985. During this period, tuberculosis occu
The lysosomal contribution to breakdown of prelabeled short- and long-lived cell proteins in the perfused rat liver was monitored in two ways. In the first, either leupeptin or chloroquine was injected into rats as well as added to the perfusate. The extent of suppression of proteolysis compared to that of controls wa
G Ital Cardiol. 1986 Sep;16(9):741-9. Unique Identifier : AIDSLINE MED/87106540
Nava A; Canciani B; Scognamiglio R; Buja GF; Daliento L; Miraglia G; Martini B; Thiene G
In this paper we report the arrhythmias recorded on basal ECG, on Holter monitoring or on exercise test, in 32 pts affected by arrhythmogenic right ventricle (ARV). A sustained ventricular tachycardia (VT) was present in 11 pts a non sustained VT in 15 pts, a slow VT in 2 pts, a ventricular fibrillation (VF) in 3 pts
Hosp Community Psychiatry. 1986 Dec;37(12):1235-8. Unique Identifier : AIDSLINE MED/87107419
Amchin J; Polan HJ
As more patients with AIDS and AIDS-related syndromes are admitted to psychiatric units, staffs must meet new diagnostic and therapeutic challenges while adapting to the unique stresses of treating these patients. The authors discuss several case vignettes to illustrate how the staff of a voluntary acute-stay psychiat
The role of radiotherapy in the treatment of epidemic Kaposi s sarcoma needs to be defined. Over the past 4 years, we have irradiated 47 Kaposi s sarcomas in 38 patients having AIDS. Doses ranging from 800 cGy in 1 fraction to 3000 cGy in 10 fractions over 2 weeks were applied on an individualized basis. Treatment gen
In a new era of increased concern about sexually transmitted diseases, the ethical focus of contraceptive counseling for the early adolescent has changed. A discussion of the ethical aspects of contraceptive counseling is included to emphasize contemporary concerns about informed consent and safe contraceptive methods
J Med Ethics. 1986 Dec;12(4):187-94. Unique Identifier : AIDSLINE MED/87112613
Kirby MD
This paper is not about the medical condition of AIDS. Nor is it about the history of the condition since it was first reported in Atlanta, Georgia in 1981. It looks rather, at the catalogue of legislative and other legal responses to the spread of AIDS. The paper analyses the AIDS condition in its historical context.
An African green monkey naturally infected with simian T-lymphotropic virus (STLV) developed spontaneous malignant lymphoma of diffuse pleomorphic type. The clinical, hematological and histopathological characteristics were very similar to those of human adult T-cell leukemia.
Lymph nodes from 40 homosexuals with persistent, generalized lymphadenopathy were studied for histological and immunohistological changes and classified into histological stages based on the progressive destruction of lymph node follicles in association with progression of the disease. Three patterns were recognized:
The aim of the present study was to investigate the relation between the histopathological findings in LAV/HTLV-III lymphadenitis and immunological, clinical, and serological variables. The study group included 38 consecutive homosexual men with persistent generalized lymphadenopathy (PGL) in whom lymph node biopsy wa
South Med J. 1987 Feb;80(2):228-32. Unique Identifier : AIDSLINE MED/87120428
Thompson LM
Acquired immunodeficiency syndrome (AIDS) has engendered a crisis of fear among the public and health professionals alike. In addition to the myriad anxieties that generally accompany dying and death, AIDS patients must deal with numerous additional fears. In rushing to treat the physiologic aspects of AIDS, health pr
AIDS is posing challenges at various public health related levels, epidemiological, clinical, social, ethical, legal. In the current absence of possibilities of curative treatment or of vaccine, it is essential to provide sufficient information on the available preventive measures. Given the increase in the numbers of
The incidence of atopic diseases and IgE production was investigated in 69 patients of the AIDS outpatient clinic. In LAV/HTLV-III infected homosexuals there was a trend to lower serum IgE levels and decreased frequency of atopic diseases. The incidence of patients with positive RAST against common environmental aller
Dupuis M; Fernandes Xavier FG; Gonsette RE; Brucher JM
A 38 year-old wife, of belgian origin and residency, suffered from a left retrobulbar optic neuritis in 1973, with as only sequel dyschromatopsia and central scotoma enlargement. In 1985, 12 years later, she complained of a progressive weakness of the right hand, and developed a spastic tetraplegia within four months.
Toxoplasma gondii cerebral abscess is a common opportunistic infection in patients affected by AIDS. Making a reliable diagnosis of acute cerebral toxoplasmosis is difficult in AIDS patients because of the lack of specificity of serological data and neuroradiological findings. Brain biopsy is the only procedure which
Am J Med. 1987 Feb;82(2):313-7. Unique Identifier : AIDSLINE MED/87124907
Schulhafer EP; Grossman ME; Fagin G; Bell KE
Kaposi s sarcoma is known to occur in a variety of immunosuppressed patients. The course of the disease varies depending on the underlying risk factors. A male homosexual patient in whom Kaposi s sarcoma developed while he was being treated with prednisone for Henoch-Schonlein purpura is described. The resolution of h
Follicular hyperplasia is the most common histologic finding in lymph nodes of patients with AIDS-related complex (ARC) and persistent generalized lymphadenopathy. To determine the specificity of the published features considered characteristic of this condition, we compared two sets of lymph-node biopsy specimens wit
Out of 286 patients with the acquired immunodeficiency syndrome (AIDS) who had fiberoptic bronchoscopies performed for the diagnosis of pulmonary disease, 21 (7.3%) patients (Group I) had repeat procedures after 1 to 30 days (mean, 14.8 days) because of persistent pulmonary infiltrates despite therapy, and 46 (15.9%)
Ann Intern Med. 1987 Mar;106(3):372-9. Unique Identifier : AIDSLINE MED/87126142
Bronnimann DA; Adam RD; Galgiani JN; Habib MP; Petersen EA; Porter B; Bloom JW
Of 27 patients with the acquired immunodeficiency syndrome (AIDS) in Tucson, Arizona, 7 had concurrent coccidioidomycosis . Early manifestations of infection in 6 patients included diffuse nodular pulmonary infiltrates and Coccidioides immitis in many extrathoracic si
Horsburgh CR Jr; Cohn DL; Roberts RB; Masur H; Miller RA; Tsang AY; Iseman MD
Susceptibility testing and serotyping were performed on 57 isolates of Mycobacterium avium-M. intracellulare from patients with acquired immunodeficiency syndrome (AIDS) and 75 isolates from patients without AIDS. Susceptibility patterns and serotypes of AIDS isolates were significantly different from those of non-AID
In three patients who died of immunodeficiency syndromes, including two patients with acquired immunodeficiency syndrome (AIDS), foci of necrotizing leukoencephalopathy were found in the basis pontis. The lesions were identical in location and morphology to those previously described in patients who received chemother
M'Pele P; Rosenheim M; Itoua-Ngaporo A; Bouramoue C; Mouanga-Yikida G; Brucker G; Duflo B; Gentilini M
We report 15 cases of symptomatic HIV infection seen in Paris between June 1983 and June 1985 in Congolese patients. The first signs were diarrhea, weight loss, fever, pruritis. Disseminated lymphadenopathy was frequent. Twelve patients had AIDS, and the opportunistic infections were: isosporosis, oesophageal candidia
Dtsch Med Wochenschr. 1987 Jan 2;112(1):4-7. Unique Identifier : AIDSLINE MED/87105079
Kuhnl P; Holzberger G; Seidl S
In a retrospective study the rate of HIV (LAV/HTLV-III)-infected recipients of blood units (excluding haemophiliacs) issued before HIV antibody testing became routine in 1985 was investigated. Screening of 200,000 donations yielded 24 seropositive blood donors. Of these 17 were homo- or bisexual, one subsequently know
The presence of antibodies to HTLV-III and markers of active hepatitis B virus replication was examined in a longitudinal study of 33 consecutive male homosexual HBsAg carriers. The mean follow-up time was 37 months (range = 4 to 109 months). All patients were initially hepatitis B virus DNA-positive and HBeAg positiv
A defect in alpha interferon production in patients with chronic type B hepatitis offers a rationale principle for treating this disease with interferon. Two trials with interferon in chronic type B hepatitis indicate that this therapy achieves an elimination of HBsAg and HBeAg significantly higher than spontaneous. O
Various 3 -azido, 3 -amino, 2 ,3 -unsaturated, 2 ,3 -dideoxy, and 5-substituted analogues of pyrimidine deoxyribonucleosides have been prepared and tested against Moloney-murine leukemia virus (M-MULV), a mammalian T-lymphotropic retrovirus in vitro. Among these compounds, the 3 -azido analogues of thymidine, 2 -deoxy
Modrow S; Hahn BH; Shaw GM; Gallo RC; Wong-Staal F; Wolf H
Independent isolates of human immunodeficiency virus (HIV) exhibit a striking genomic diversity, most of which is located in the viral envelope gene. Since this property of the HIV group of viruses may play an important role in the pathobiology of the virus, we analyzed the predicted amino acid sequences of the envelo
The ultrastructural morphology of Kaposi s sarcoma in the skin and mucous membranes of the head and neck regions of patients with acquired immune deficiency syndrome (AIDS) was examined electron microscopically. It was found that the tumour consisted of neoplastic spindle cell aggregates, vascular endothelial cell pro
Med Trop (Mars). 1986 Oct-Dec;46(4):345-8. Unique Identifier : AIDSLINE MED/87115068
Forcain M; Samson P; Matali P; Nicolas J; Bouyou Mananga E; Gilot Y; Lecamus JL; Aubry P
A.I.D.S. is a true public health problem in Central Africa since its appearance in 1983. Several authors have described its clinical manifestations, as well as the absence of groups at risk and a sex ratio near to 1. The present study, carried out in Pointe-Noire hospital (Popular Republic of Congo) tries to select in
The human T-cell leukemia/lymphotropic virus type III (HTLV-III), the causative agent of the acquired immunodeficiency syndrome (AIDS), has been isolated from the tears of five AIDS patients. When combined with data from our previous study, 5 of 16 samples from patients with AIDS or AIDS-related complex (ARC) showed p
In order to determine the contamination level of French hemophiliacs with the retrovirus LAV/HTLVIII, a national investigation of 1,670 hemophiliacs was performed. Results demonstrated that 49% were seropositive for LAV/HTLVIII antibodies. Of these 12.4% had clinical and/or biological symptoms of immunodeficiency. Reg
Science. 1987 Feb 13;235(4790):790-3. Unique Identifier : AIDSLINE MED/87120321
Pedersen NC; Ho EW; Brown ML; Yamamoto JK
A highly T-lymphotropic virus was isolated from cats in a cattery in which all the animals were seronegative for feline leukemia virus. A number of cats in one pen had died and several had an immunodeficiency-like syndrome. Only 1 of 18 normal cats in the cattery showed serologic evidence of infection with this new vi
In order to evaluate the operational implications of excluding donated blood with antibody to hepatitis B core antigen (anti-HBc), the American Red Cross tested 107,473 voluntary blood donations for anti-HBc in 72 test sites during a 1-week period. The system-wide prevalence of anti-HBc was 2.60 percent, with a range
Gelderblom HR; Hausmann EH; Ozel M; Pauli G; Koch MA
Ultrathin section and surface replica electron microscopy were applied in combination with immunoelectron microscopy to elucidate the fine structure of HIV. The shell of the tubular core shows p24 antigenicity, while p17 is located at the inner leaflet of the lipid membrane. The virus particle is studded with 70-80 pr
Tersmette M; de Goede RE; Over J; de Jonge E; Radema H; Lucas CJ; Huisman HG; Miedema F
Inactivation of human immunodeficiency virus (HIV) in lyophilised small pool cryoprecipitate, factor VIII concentrate, prothrombin complex and C1-esterase inhibitor concentrate by prolonged heat treatment (72 h, 60 degrees C) was studied. Plasma products, inoculated prior to lyophilisation, had infectious titres rangi
Ramsey RB; Evatt BL; McDougal JS; Feorino P; Jackson D
The prevalence of antibody to human immunodeficiency virus (HIV) was determined in various commercial substrate plasmas used in clotting factor assays, and viral isolation was attempted from both seropositive and seronegative samples. Antibody to HIV was detected in 13 of 13 plasma substrates used for Factor VIII assa
Am J Psychiatry. 1987 Feb;144(2):176-81. Unique Identifier : AIDSLINE MED/87125360
Binder RL
An antibody test for the causative virus of the acquired immune deficiency syndrome (AIDS) became commercially available in 1985. The author discusses the use of the AIDS antibody test on inpatient psychiatric units. She reviews the controversial legal and ethical questions related to its use, addressing such question
Human immunodeficiency virus (HIV) has been isolated from both male and female genital secretions. We evaluated the pattern of female genital carriage during the menstrual cycle, and its relationship to HIV viremia. Seven menstruating seropositive women and one seronegative control had cervical secretions and venous b
Franchini G; Robert-Guroff M; Aldovini A; Kan NC; Wong-Staal F
The genome of the HTLV-III/LAV retrovirus, the etiologic agent of the acquired immunodeficiency syndrome (AIDS), encodes the viral structural proteins (envelope and core proteins), the reverse transcriptase, a transactivation protein (tat-III), as well as two other proteins (3 orf, sor) of unknown function. We studied
Two panels consisting of 236 and 258 anti-LAV/HTLV III positive and 64 and 50 negative sera, respectively (determined in Western blots), were tested with 8 different, commercially available ELISA test kits for detecting LAV/HTLV III antibodies (Abbott, Dupont, Electro-Nucleonics, Litton, Organon, Pasteur, Sorin, Wellc
Hagberg L; Malmvall BE; Svennerholm L; Alestig K; Norkrans G
Two cases of HIV infection associated with Guillain-Barre syndrome are described. The neurologic symptoms started 1 week and 20 weeks, respectively, after the primary HIV infection. Seroconversion for anti-HIV occurred during the disease. A rapid spread of virus to the central nervous system was shown.
Z Hautkr. 1986 Dec 1;61(23):1681-4. Unique Identifier : AIDSLINE MED/87122586
Minnemann M
Our experiences gained in the AIDS clinic of the department of dermatology of the University of Cologne since 1983 have shown that the medical care of patients infected with LAV/HTLV III (HIV) may well be performed by physicians in practice. This especially refers to patients with the stages WR 1 and 2. We discuss our
A case of Kaposi s sarcoma in lymph nodes aspirated by fine needle is presented. The cytologic findings were highly suggestive of Kaposi s sarcoma, and the histologic examination confirmed the diagnosis. It was then discovered that the patient was homosexual. Viral studies did not reveal the presence of HTLV virus.
Ann Intern Med. 1987 Mar;106(3):383-6. Unique Identifier : AIDSLINE MED/87126144
Holzman RS; Walsh CM; Karpatkin S
A group of 44 homosexual patients with immune thrombocytopenia and serologic evidence of infection with the human immunodeficiency virus (HIV) was observed for a total of 844 person-months. The risk of developing the acquired immunodeficiency syndrome (AIDS), an actuarial incidence of 36.5% in 37 months, was no differ
Previous reports have shown the capacity of diphenylhydantoin (DPH) to attach to the membranes of lymphatic cells as a hapten and thus exert an unspecific influence on their ability to express certain recognition molecules. This led us to the hypothesis, that DPH might as well serve to manipulate the t-helper-lymphocy
The activity of the alpha interferons against AIDS-related Kaposi s sarcoma (KS) has been demonstrated in numerous clinical trials. Unfortunately, most reports have involved small patient cohorts and a variety of dosages and schedules of administration. We report here a series of Phase II trials with interferon alfa-2
Cancer. 1987 Feb 15;59(4):731-8. Unique Identifier : AIDSLINE MED/87102501
Burkes RL; Abo W; Levine AM; Linker-Israeli M; Parker JW; Gill PS; Krailo M; Horwitz DA
A syndrome of persistent, generalized lymphadenopathy (PGL), related to the acquired immune deficiency syndrome (AIDS), has been described in homosexual men. To further characterize and correlate the immunologic status of patients with PGL with those in AIDS, we studied spontaneous and pokeweed mitogen (PWM)-induced I
Proliferative responsiveness to, and production of, interleukin 2 ( IL-2 ) was determined in 9 homosexually active men with the acquired immunodeficiency syndrome (AIDS) and in 28 homosexually active men with the persistent generalized lymphadenopathy syndrome (PGL). All
Kennedy CR; Bird D; Chrzanowska K; Stephens S; Webster AD
Thirty-two patients, including 29 children, presenting with acute unexplained encephalopathies were studied prospectively for evidence of virus infection, immunodeficiency, and immunologic involvement in the pathogenesis of their illnesses. Twenty-five of these patients had a clinical diagnosis of encephalitis. Twenty
Int J Cancer. 1987 Feb 15;39(2):182-4. Unique Identifier : AIDSLINE MED/87108018
Melbye M; Kestens L; Biggar RJ; Schreuder GM; Gigase PL
In the search for a genetic factor involved in the etiology of Kaposi s sarcoma, several studies have recently focused on a significantly increased HLA determinant, DR5, as well as a decreased DR3, among patients with both the classical and the AIDS-related form of Kaposi s sarcoma. To test the consistency of this phe
Greenspan D; Greenspan JS; Hearst NG; Pan LZ; Conant MA; Abrams DI; Hollander H; Levy JA
We investigated the relation of oral hairy leukoplakia (HL) to human immunodeficiency virus (HIV) infection and to the presence or development of AIDS. All 155 patients with HL seen in our clinic were immunosuppressed homosexual men. Of 101 serum samples obtained from patients in this group who did not have AIDS, 100
Class II histocompatibility DR antigen alpha and beta chains were isolated from preparations of human T-cell lymphotropic virus type III grown in human H-9 cells. The proteins were purified by reversed-phase high-pressure liquid chromatography and identified by direct N-terminal amino acid sequence analysis of each ch
Two commercially available enzyme-linked immunosorbent assays (ELISA) were compared in screening a large population of volunteer blood donors. One ELISA utilized the human T-lymphotropic virus, Type III (HTLV-III) grown on National Institutes of Health T-lymphocyte cell line, H-9, as antigen source; the second used ly
Infection of human helper T lymphocytes with the human immunodeficiency virus (HIV) results in a rapid induction of cytopathic effects and cell lysis. We isolated a variant of the human T-lymphoblastoid cell line, CEM, that is fully susceptible to HIV infection but resistant to virally induced cytopathic effects. Expo
Ann Intern Med. 1987 Mar;106(3):396-8. Unique Identifier : AIDSLINE MED/87126148
Coulman CU; Greene I; Archibald RW
A 42-year-old man with the acquired immunodeficiency syndrome (AIDS) presented with a 9-month history of progressive hearing loss and bilateral external auditory canal masses. Biopsy of the right ear mass detected Pneumocystis carinii. The patient was treated with a 7-day course of intravenous trimethoprim, followed b
Artificial insemination by donor (AID) provides a necessary service to a significant number of infertile couples. Its practice has been well controlled in Australia by careful donor screening and selection of suitable recipients. The potential for transmission of several infecti
Immunofluorescence studies of plasma cells were performed on small intestinal and colonic biopsies obtained from a series of patients with acquired immunodeficiency syndrome or the AIDS related complex plus homosexual male and heterosexual controls. The AIDS group was significantly depleted of IgA plasma cells compare
The authors report a case of ulcerative colitis due to Histoplasma capsulatum in a previously healthy 35 year-old french geologist with acquired immune deficiency syndrome (AIDS). Gomori-Grocott and PAS stains and indirect immunofluorescence revealed Histoplasma capsulatum in colonic biopsies. The search for LAV antib
Retroviruses are known to incorporate cellular antigens as they bud from infected cells. To identify the cellular antigens that associate with the AIDS-retrovirus, we evaluated a preparation of HTLV-III antigens with a panel of monoclonal antibodies reactive with a variety of antigens expressed on the H9 T-cell line u
We have studied the natural history of the acquired immune deficiency syndrome (AIDS), and the part that irradiation plays in the management of this devastating and fatal disease. The radioresponsiveness of the two most common malignancies associated with AIDS, Kaposi s sarcoma (KS) and malignant lymphoma (ML), has be
Malignant lymphoma rarely involves the heart at initial presentation. We have cared for nine cases in the past 8 years. The median age was 45 years (range, 27 to 68). Initial presenting symptoms included chest pain in four, gastrointestinal (GI) symptoms in three, and constitutional B symptoms in two. Echocardiography
Human T-lymphotropic virus type III (HTLV-III/LAV or HIV) contains a gene designated art (anti-repressor transactivator). Here, we report the expression of the art gene product in bacteria and show that the 20-kilodalton (kDa) bacterially expressed art protein is recognized by serum of a patient. The bacterially synth
The AIDS dilemma continues to escalate, leaving a legacy that probably will affect the nation for years to come. The U.S. Centers for Disease Control, the National Academy of Sciences, and the U.S. Surgeon General have noted that in the absence of a vaccine or treatment for AIDS, education remains the only effective m
Med Oncol Tumor Pharmacother. 1986;3(3-4):211-21. Unique Identifier : AIDSLINE MED/87114212
Goldstein AL; Schulof RS; Naylor PH; Hall NR
For years, scientists have searched for ways to trigger the body s own defenses against cancer and other diseases associated with abnormal immunity. This search has led to the discovery of a number of important new biological and chemical substances that augment, direct or restore many of the normal defenses of the bo
N Engl J Med. 1987 Feb 26;316(9):557-64. Unique Identifier : AIDSLINE MED/87115718
Yarchoan R; Broder S
We review the rationale for, and progress in, the development of antiviral therapy for the acquired immunodeficiency syndrome (AIDS). A consideration of the replicative cycle of the human immunodeficiency virus (HIV) can lead to the identification of several steps that represent potential targets for antiretroviral th
AIDS of childhood is reviewed in this timely article, including care of the child with infectious complications, and other current and future management concerns.
De Majo E; Ravina A; Ricciarelli L; Parri F; Mazzetti M; Di Pietro M; Colao MG; Milo D; Romagnani S
The prevalence of specific antibodies to HTLV-III/LAV retrovirus was investigated during 1985 in a large group of subjects at risk for AIDS living in the Florence area. Two hundred and thirty-two of 774 (29.9%) intravenous drug users (IDU), 40 of 164 homosexuals (24.3%), 43 of 147 hemophiliacs (29.2%), 7 of 10 childre
Biberfeld G; Bottiger B; Berntorp E; Schulman S; Egberg N; Stigendal L; Blomback M; Nilsson IM
The prevalence of HIV antibodies in 44 heterosexual female partners and 56 nonsexual family household contacts of 61 HIV seropositive haemophiliacs (41 adults and 20 children or adolescents) was determined to evaluate the risk of transmission of HIV infection. HIV antibodies were determined by enzyme-linked immunosorb
We have previously reported that, in long-term renal allograft recipients who receive chronic chemical immunosuppression and who are at risk for late chronic viral infections and virus associated tumors, the percentage of lymphocytes the phenotype of which is Leu-7+/Leu-11(-) (CD16) is markedly and significantly incre
From June 1977 to March 1985, 572 renal transplants were performed at The University of Texas Medical School at Houston. This represented 220 patients (151 cadaveric [CAD] and 69 living-related donor [LRD] recipients) treated with azathioprine and prednisone (Aza-Pred) and 352 patients (250 CAD and 102 LRD) treated wi
We have evaluated a newly developed competitive enzyme immunoassay for the specific detection of antibodies against LAV/HTLV III envelope and core proteins. Comparative studies of sera from high-risk donors showed complete concordance between the results of the confirmatory enzyme immunoassay and immunoblot or indirec
Inflammatory and transmissible disorders of the central nervous system are a heterogeneous group with regard to clinical presentation, character of the histologic lesions, and nature of etiologic agent, if known. The diagnosis of many of these requires an index of suspicion, special histologic or immunohistologic proc
The effects of the current HTLV-III epidemic are of considerable significance to the general public and health care system. It is a new disease with diverse ramifications . . . not all of which are understood. Many drugs are being evaluated in clinical trials, but at present, they are not expected to be able to rid an
Ann Intern Med. 1987 Mar;106(3):421-33. Unique Identifier : AIDSLINE MED/87126153
Fauci AS; Rosenberg SA; Sherwin SA; Dinarello CA; Longo DL; Lane HC
A major difficulty limiting the use of immunomodulators in clinical medicine has been the complexity of the immunoregulatory network in which modulation of one component usually perturbs the entire system, thus diminishing the specificity of the approach. Lymphokine-activated killer cells infused with interleukin-2 ha
Colon and rectum localizations of an disease or a parasitosis depend essentially on the nature of the pathogenous agent and the host resistance. Acute enterocolitis is secondary to enterotoxinogenous germs (such as cholera vibrio), invasive germs (such as shigella), penetrating germs (such as salmonella); viruses are
Human T cell lymphotropic virus type III (HTLV-III)/lymphadenopathy-associated virus is the etiologic agent of the acquired immune deficiency syndrome (AIDS) and AIDS-related complex. The effect of 3 -azido-3 -deoxythymidine ( AZT ) on the HTLV-III/lymp
Br Med J (Clin Res Ed). 1986 Dec 6;293(6560):1459-62. Unique Identifier : AIDSLINE MED/87101905
Lange JM; Paul DA; Huisman HG; de Wolf F; van den Berg H; Coutinho RA; Danner SA; van der Noordaa J; Goudsmit J
Sequential serum samples from 13 homosexual men who seroconverted for antibodies to human immunodeficiency virus (HIV) were tested for HIV antigen. In one of these men, who developed the acquired immune deficiency syndrome (AIDS), HIV antigenaemia preceded the onset of AIDS by more than a year and persisted throughout
Gramatzki M; Nusslein H; Burmester GR; Rodl W; Heyder N; Grote W; Monner DA; Muhlradt PF; Kalden JR
Patients with opportunistic infections during the course of acquired immunodeficiency syndrome (AIDS) were analyzed for cellular immune functions and found to be severely immunocompromised. In particular, interleukin 2 (IL 2) production appeared to be defect not only qualitatively but also quantitatively. In some of t
We investigated the expression of the interleukin-2 ( IL-2 ) receptor on phytohaemagglutin-stimulated peripheral blood lymphocytes from homosexual men with persistent generalized lymphadenopathy, the prodrome of the acquired immune deficiency syndrome. The subjects were
Penneys NS; Kott-Blumenkranz R; Civantos F; Kent J
Consistent elevations of plasma von Willebrand factor antigen were observed in otherwise healthy elderly patients with Kaposi s sarcoma. The elevations were predominantly of the endothelial cell--derived antigen, as opposed to the factor VIII procoagulant, with resultant elevations in the antigen/procoagulant ratios.
Tschachler E; Groh V; Popovic M; Mann DL; Konrad K; Safai B; Eron L; diMarzo Veronese F; Wolff K; Stingl G
Langerhans cells (LC) are bone marrow-derived, Ia+, CD1+, CD4+, ATPase+ dendritic antigen-presenting cells within the human epidermis. Since the CD4 molecule has been implicated as a receptor structure for HTLV-III/LAV (human T-cell leukemia virus/lymphadenopathy-associated virus), we asked whether LC from HTLV-III/LA
Dolei A; Fattorossi A; D'Amelio R; Aiuti F; Dianzani F
The replication of the human T lymphotropic retrovirus HTLV-III in persistently infected cells is relatively insensitive to the direct antiviral action of human interferon-alpha or -gamma (IFN-alpha or -gamma), showing only a two- to threefold reduction of HTLV-III, even though the host cells are very sensitive to IFN
Public Health Rep. 1987 Jan-Feb;102(1):5-17. Unique Identifier : AIDSLINE MED/87118715
Scitovsky AA; Rice DP
This study presents three estimates--ranging from low to high--of the direct and indirect costs of the AIDS epidemic in the United States in 1985, 1986, and 1991, based on prevalence estimates provided by the Centers for Disease Control (CDC). According to what the authors consider the
Am J Hematol. 1987 Feb;24(2):169-76. Unique Identifier : AIDSLINE MED/87124796
Kim HC; Nahum K; Raska K Jr; Gocke DJ; Kosmin M; Karp GI; Saidi P
During the 5-year period from 1981 to 1985, we have observed 8 cases of acquired immunodeficiency syndrome (AIDS) among our 85 patients with hemophilia A. Thus, the prevalence of AIDS with hemophilia A is 9.4% in our patient population. By utilizing stored serum or plasma samples dating back to 1978, antibody against
Pileri S; Rivano MT; Raise E; Gualandi G; Gobbi M; Martuzzi M; Gritti FM; Gerdes J; Stein H
The morphological and immunohistochemical findings in lymph nodes of nine patients with the acquired immunodeficiency syndrome (AIDS) and 81 patients with the AIDS-related complex (ARC) are presented. Three basic histological patterns were observed: follicular hyperplasia (29 cases), mixed hyperplasia (49 cases) and l
A panel of 47 blood group antibodies covering a range of blood group antigens has been tested in the presence of 680 mumol concentration sodium phosphonoformate as a putative chemical additive to serum to reduce infectivity of high risk HTLV-III/HBsAg samples. No inhibitory effect could be demonstrated using the ind
Z Hautkr. 1986 Dec 1;61(23):1671-8. Unique Identifier : AIDSLINE MED/87122585
Steigleder GK; Rasokat H; Wemmer U
Four patients suffering from immune deficiency related to HTLV III developed psoriasis vulgaris. All patients showed lymphadenopathy and cutaneous hypergy or anergy. In three of them, the count of peripheral helper cells was critically decreased (less than 400/microliter), and they showed oral candidosis. One patient
Z Hautkr. 1986 Dec 1;61(23):1687-704. Unique Identifier : AIDSLINE MED/87122587
Lechler E
The recognition of AIDS in several hemophiliacs in the U.S.A. in 1982 has contributed to the understanding that this disease may be transmitted by blood and blood products and that it is of infectious nature. American factor VIII and factor IX concentrates as well as the high portion of American plasma used in the pro
Am Fam Physician. 1987 Feb;35(2):137-42. Unique Identifier : AIDSLINE MED/87124310
Guidotti TL
Hospitals present a variety of infectious, chemical and physical hazards to their workers. Important pathogens include AIDS, hepatitis B and rubella viruses and Mycobacterium tuberculosis. Ethylene oxide is probably the greatest chemical hazard, but anesthetic gases, antineoplastic drugs and skin irritants or sensitiz
We previously reported a high incidence of acquired immune deficiency syndrome (AIDS) in Kinshasa, Zaire , as well as a high frequency of antibody to human immunodeficiency virus (HIV), which includes HTLV-III and LAV viruses, in persons without AIDS. In this report we assessed the
Schulof RS; Scheib RG; Parenti DM; Simon GL; DiGioia RA; Paxton HM; Sztein MB; Chandra P; Courtless JW; Taguchi YT; et al
13 asymptomatic, HTLV-III/LAV-infected male homosexuals with generalized lymphadenopathy were treated with oral D-penicillamine. All patients had depressed T4/T8 ratios and 12 had impaired T-cell function. An escalating dose schedule was employed over 2-6 weeks with doses from 0.5 to 2 g/day. Generalized skin rashes d
Tsubai F; Namba Y; Kohno M; Hanada S; Matsumoto M; Shamoto M; Hanaoka M
A monoclonal antibody, FTF 148, was prepared by hybridizing murine myelomal cells (NS-1) and spleen cells of BALB/c mice immunized with cultured cells derived from an adult T cell leukemia (ATL) patient (KUT-2 cells). This monoclonal antibody reacted with all of the human T cell leukemia virus I (HTLV-I)-infected cell
Cell. 1987 Jan 30;48(2):343-50. Unique Identifier : AIDSLINE MED/87102881
Maruyama M; Shibuya H; Harada H; Hatakeyama M; Seiki M; Fujita T; Inoue J; Yoshida M; Taniguchi T
In this study we provide evidence that distinct DNA sequences within the 5 -flanking regions of the genes for interleukin-2 ( IL-2 ) and its receptor (IL-2R) are involved in human T-cell-specific activation of transcription by p40x, a product of human T cell leukemia vir
Ragona G; Sirianni MC; Soddu S; Vercelli B; Sebastiani G; Piccoli M; Aiuti F
Patients affected by AIDS-related complex (ARC) show several immunological abnormalities which may lead to a disregulation of immunosurveillance against viral latent infections. In this paper evidence for Epstein-Barr virus (EBV) reactivation in seven out of eight affected by persistent generalized lymphadenopathy is
Overwhelming pneumonias remain an important cause of morbidity and mortality. These illnesses may be rapidly fatal; thus, many patients are treated empirically. Although the various etiologic agents cannot be differentiated on the basis of radiographic appearance, epidemiologic information may give a clue to the cause
Dtsch Med Wochenschr. 1987 Jan 16;112(3):100-3. Unique Identifier : AIDSLINE MED/87105096
Bertram U; Willems WR; Lampert F; Bauer H
Cytomegalovirus ( CMV ) was isolated from the urine of babies from two consecutive pregnancies of a mother. The first baby had died of pneumonia at the age of six months, two years before the second confinement (twins of different sexes). The male twin was examine
Dtsch Med Wochenschr. 1987 Jan 30;112(5):178-81. Unique Identifier : AIDSLINE MED/87105126
Flik J; Milbradt H; Wahlers T; Schafers HJ; Haverich A
After repeated administration of relatively high doses of a cytomegalovirus immunoglobulin preparation to two patients after heart transplantation, both the ELISA and the immuno-blot tests became temporarily positive (for 21 and 41 days, respectively) to HIV antibodies. The
FEBS Lett. 1987 Jan 19;211(1):17-22. Unique Identifier : AIDSLINE MED/87105941
Ruff MR; Martin BM; Ginns EI; Farrar WL; Pert CB
The octapeptide Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr (peptide T) and two structural analogs are potent agonists of human monocyte chemotaxis, evincing identical rank potency orders as was previously shown for their inhibition of human immunodeficiency virus (HIV) envelope binding and T cell infectivity. Chemotactic activit
The infection of a number of new and established B-cell lines by human T-cell lymphotropic virus III (HTLV-III) was investigated. The B lymphocytes differed in their expression of T4 antigens detected by specific monoclonal antibodies (MAbs) and the presence of Epstein Barr virus (EBV)-DNA or antigens. The presence of
The nucleoside analog 2 ,3 -dideoxycytidine (ddCyd) has been shown to inhibit the infectivity and cytopathic effect of human immunodeficiency virus on human OKT4+ lymphocytes in vitro. Metabolism of ddCyd by human T-lymphoblastic cells (Molt 4) negative for human immunodeficiency virus and OKT4 was examined. Molt 4 ce
J Immunol. 1987 Feb 15;138(4):1064-7. Unique Identifier : AIDSLINE MED/87110643
Rook AH; Lane HC; Folks T; McCoy S; Alter H; Fauci AS
The causative agent of the acquired immunodeficiency syndrome (AIDS) has been shown to be a human retrovirus called human T lymphotropic virus (HTLV)-III or lymphadenopathy-associated virus (LAV). The nature of the protective immune response against this virus is currently unknown. We report here results using an anti
J Immunol. 1987 Feb 15;138(4):1208-14. Unique Identifier : AIDSLINE MED/87110666
Ganea D; Cearlock D; Minowada J; Dray S
A previous report from our laboratory indicated that a proteinase inhibitor is produced by rabbit T lymphocytes. We now report that a human T cell line, C91/PL, produces a proteinase inhibitor which inhibits the enzymatic activity of trypsin and kallikrein. This newly identified proteinase inhibitor (LPI 1) did not in
A DNA clone of human T cell leukaemia virus type I (HTLV-I) was isolated from extrachromosomal closed circular copies in chronically infected promyelocytic leukaemia HL60 cells. The new HTLV-I isolate had an intact reading frame in the gag-pol region which could encode protein of 234 amino acids. This open reading fra
Strain C57BL/6 (B6) mice infected with LP-BM5 murine leukemia virus (MuLV) develop a disease which combines abnormal lymphoproliferation with profound immunosuppression and has many features in common with human acquired immunodeficiency syndrome induced by HTLV-III/LAV retroviruses. To determine whether this LP-BM5 M
The human T-cell leukemia virus type I (HTLV-I) p40x protein is a 40-kilodalton polypeptide encoded in the 3 -terminal region of the virus. This protein is responsible for positive transcriptional trans-activation of promoter elements located within the HTLV-I long terminal repeat. We introduced the protein-coding reg
33 children with acute lymphatic leukemia and 33 healthy controls were longitudinally studied for herpesvirus infections. Active herpes simplex-virus, varicella-zoster virus and cytomegalovirus ( CMV ) infections were more freq
Investigations of retroviruses, possible etiological agents of T-cell human leukemias and acquired immunodeficiency syndrome are reviewed. Main attention is paid to the genome structure and function.
Nature. 1987 Jan 29-Feb 4;325(6103):453-5. Unique Identifier : AIDSLINE GENBANK/X04836
Littman DR; Gettner SN
The T-cell surface glycoprotein, CD4, is expressed predominantly on helper T cells and is thought to play a major role in cell-cell interactions. Monoclonal antibodies against CD4 have been shown to block numerous T-cell functions; moreover, recent results suggest that the CD4 molecule may be involved in transmembrane
An unexplained peripheral neuropathy was observed in five patients with positive serology for LAV/HTLV III. Three of them presented with polyneuropathy, one with chronic meningitis and oculomotor palsies, and one with a mononeuropathy. CSF was abnormal in 5/5, with el
Science. 1987 Feb 6;235(4789):674-7. Unique Identifier : AIDSLINE MED/87120302
Wachsman W; Cann AJ; Williams JL; Slamon DJ; Souza L; Shah NP; Chen IS
The human T-cell leukemia viruses, HTLV-I and HTLV-II, contain a gene, termed x, with transcriptional regulatory function. The properties of the x proteins were analyzed by constructing mutant genes containing site-directed deletions and point mutations. The results demonstrate that the amino terminal 17 amino acids o
Science. 1987 Feb 20;235(4791):901-4. Unique Identifier : AIDSLINE MED/87120335
Kitado H; Chen IS; Shah NP; Cann AJ; Shimotohno K; Fan H
Human T-cell leukemia virus (HTLV) types I and II are unusual among replication-competent retroviruses in that they contain a fourth gene (chi) necessary for replication. The chi gene product, p chi, transcriptionally transactivates the viral long repeat (LTR), and is thus a positive regulator. To investigate p chi tr
The proteolytic processing of the gag precursor polypeptide pr65gag of simian sarcoma-associated virus (SSAV) has been studied in vivo and in vitro. In SSAV-infected cells (i.e., in vivo) proteins of 52 and 38 kDa and the viral protein p30 could be immunoprecipitated with anti-p30 serum. This cleavage pattern is only
Opportunistic infections are the most common initial manifestations of AIDS and, in many instances, are first encountered in surgical specimens. Pneumocystis carinii pneumonitis is by far the most frequent infection seen in biopsy specimens of AIDS patients. Most pathologists are familiar with its histopathologic pres
Ann Med Interne (Paris). 1986;137(7):562-4. Unique Identifier : AIDSLINE MED/87126240
Jacob L; Sereni D; Maisonneuve P; Bardin JM; Cattan E; Sultan Y; Cremer GA; Laroche C
The authors report the first two cases of lethal AIDS in haemophilia A in France . One French case of AIDS in haemophilia B has already been reported. The diagnosis was based on the observation of opportunist infections associated with severe depression of cell-mediated immunity in
Between 1982 and 1985, 21 patients with acquired immunodeficiency syndrome (20 men and one woman; mean age, 36 years) underwent 31 surgical procedures at the Harbor/UCLA Medical Center, Torrance, or the UCLA Medical Center (skin, lymph node, and endoscopic biopsies were excluded). The operations included seven emergen
Biochem Biophys Res Commun. 1987 Jan 15;142(1):128-34. Unique Identifier : AIDSLINE MED/87128077
Baba M; Pauwels R; Herdewijn P; De Clercq E; Desmyter J; Vandeputte M
2 ,3 -Dideoxythymidine (ddThd) and its 2 ,3 -unsaturated derivative 2 ,3 -dideoxythymidinene (ddeThd) are potent and selective inhibitors of human immunodeficiency virus (HIV) in vitro. When evaluated for their inhibitory effects on the cytopathogenicity of HIV in MT-4 cells, ddThd and ddeThd completely protected the
Adult T-cell leukemia (ATL) in Japan is remarkably concentrated in adult T-cell leukemia virus (ATLV)-endemic areas and this limited distribution and other epidemiological analysis have strongly suggested the possibility of familial spreading of ATLV. I am interested in whether ATLV
Gan No Rinsho. 1986 Dec;32(15):1970-3. Unique Identifier : AIDSLINE MED/87113262
Toki H; Okabe K; Kimura Y; Kamei H; Fujishita M
A serological study of antibody to adult T-cell leukemia-virus-associated antigen (anti-HTLV-I antibody) was made in 170 cases of various hematological diseases at Shikoku Cancer Center Hospital. The titer of anti-HTLV-I antibody was determined by indirect immunofluorescence using the MT-2 cell line. Two of two patien
Med Oncol Tumor Pharmacother. 1986;3(3-4):265-7. Unique Identifier : AIDSLINE MED/87114218
Gallo RC
Since 1980 four members of a new retrovirus family called the human T-lymphotropic viruses (HTLV-I to -IV) have been discovered and to a large extent characterised. Important common features of these viruses are: transmission by sexual contact or blood, tropism for the T4-lymphocyte and the effects of a viral transact
Lancet. 1987 Jan 17;1(8525):119-22. Unique Identifier : AIDSLINE MED/87114315
Weber JN; Clapham PR; Weiss RA; Parker D; Roberts C; Duncan J; Weller I; Carne C; Tedder RS; Pinching AJ; et al
Sequential sera from 48 subjects infected with human immunodeficiency virus type I (HIV-I) were examined over 36 months for the presence of neutralising antibodies, and for specific anti-gag (p24) and anti-env (gp41) antibodies to HIV-I. Results were interpreted in terms of clinical outcome during the period 1982/3 to
Lancet. 1987 Jan 17;1(8525):128-32. Unique Identifier : AIDSLINE MED/87114318
Brun-Vezinet F; Rey MA; Katlama C; Girard PM; Roulot D; Yeni P; Lenoble L; Clavel F; Alizon M; Gadelle S; et al
Lymphadenopathy-associated virus type 2 (HIV 2) was isolated from 3 patients with AIDS and 1 with AIDS-related complex. Clinical features were similar to those in patients infected with HIV 1. Viral isolates were characterised by hybridisation with HIV 1 and HIV 2 DNA probes. HIV 1 and HIV 2 serological studies were p
Lancet. 1987 Jan 17;1(8525):132-5. Unique Identifier : AIDSLINE MED/87114319
Yarchoan R; Berg G; Brouwers P; Fischl MA; Spitzer AR; Wichman A; Grafman J; Thomas RV; Safai B; Brunetti A; et al
Four patients with human-immuno-deficiency-virus-associated neurological disease were treated with 3 -azido-3 -deoxythymidine ( AZT ). Three (two with chronic dementia , and one with chronic dementia and
Lancet. 1987 Feb 14;1(8529):345-9. Unique Identifier : AIDSLINE MED/87114508
Kingsley LA; Detels R; Kaslow R; Polk BF; Rinaldo CR Jr; Chmiel J; Detre K; Kelsey SF; Odaka N; Ostrow D; et al
2507 homosexual men who were seronegative for human immunodeficiency virus (HIV) at enrollment were followed for six months to elucidate risk factors for seroconversion to HIV. 95 (3.8%) seroconverted. Of men who did not engage in receptive anal intercourse within six months before baseline and in the six-month follow
A new dot enzyme immunoassay (EIA) with a conserved portion of the envelope protein of the human immunodeficiency virus (HIV) as antigen has been designed for use in areas with few laboratory facilities and by personnel with little laboratory experience. Sera were tested in 263 subjects who had AIDS or AIDS-related co
Lancet. 1987 Feb 21;1(8530):408-11. Unique Identifier : AIDSLINE MED/87114563
Denis F; Barin F; Gershy-Damet G; Rey JL; Lhuillier M; Mounier M; Leonard G; Sangare A; Goudeau A; M'Boup S; et al
Serological investigations in the Ivory Coast indicate that, despite the rarity of overt acquired immunodeficiency syndrome (AIDS), human immunodeficiency virus (HIV) is widely prevalent. So also is human T-lymphotropic virus type IV (HTLV-IV). The highest rates of HIV and HTL
Lancet. 1987 Feb 21;1(8530):415-6. Unique Identifier : AIDSLINE MED/87114565
Newton M; Cruickshank K; Miller D; Dalgleish A; Rudge P; Clayden S; Moseley I
Of 13 West-Indian-born UK residents with spastic paraparesis of unknown cause, 11 were tested for serum antibody to human T-cell lymphotropic virus type 1 and all were positive. Their magnetic resonance imaging scans were normal or showed only minor abnormalities in the brain, and the spinal cord was normal in the 5 i
Philos Trans R Soc Lond B Biol Sci. 1986 Dec 15;314(1167):533-70. Unique Identifier : AIDSLINE MED/87118458
Anderson RM; May RM
Recent theoretical and empirical studies of the population biology of infectious diseases have helped to improve our understanding of the major factors that influence the three phases of a successful invasion, namely initial establishment, persistence in the longer term and spread to other host communities. Of central
We studied cell surface markers in 8 men with T-cell chronic lymphocytic leukaemia, using fluorescein-conjugated monoclonal antibodies and a cell analyser/sorter. 1 patient s cells had a T-suppressor/cytolytic phenotype (T4-, T8+) and in 3 patients the phenotype was a T-helper cell (T4+, T8-) as described in retroviru
Ann Intern Med. 1987 Mar;106(3):361-8. Unique Identifier : AIDSLINE MED/87126140
Gibbs WN; Lofters WS; Campbell M; Hanchard B; LaGrenade L; Cranston B; Hendriks J; Jaffe ES; Saxinger C; Robert-Guroff M; et al
Of 95 patients consecutively diagnosed with non-Hodgkin lymphoma, 52 (55%) had antibodies to human T-cell leukemia-lymphoma virus, type I. Antibody positivity was strongly associated with skin involvement, leukemia, and hypercalcemia (p less than 0.02). Two patients had systemic opportunistic infections. Neither menin
New York Supplement, 2d Series. 1986 Jan 6 (date of decision);497:979-984. Unique Identifier : AIDSLINE KIE/22078
A preliminary injunction was granted to the City of New York by the New York Supreme Court on a finding that the closing of a public bathhouse as a nuisance under state regulations did not violate patrons First Amendment rights of association and privacy. The City had presented evidence that sexual activity with a h
University Available from the Intergovernmental Health Policy Project, George Washington University, 2100 Pennsylvania Ave., N.W., Washington, D.C. 20037, 202/872-1445, 1987 Jan 19 p Unique Identifier : AIDSLINE KIE/22118
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