ONCOGENES AND PATHWAYS TO MALIGNANCY NLM AIDSLINE Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

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ONCOGENES AND PATHWAYS TO MALIGNANCY

Control of Animal Cell Proliferation. Volume 1. Boynton AL, Leffert HL, eds. New York, Academic Press, p. 3-24, 1985.. Unique Identifier : AIDSLINE ICDB/87628346
Aaronson SA; Tronick SR; Robbins KC; Lab. of Cellular and Molecular Biology, NCI, NIH, Bethesda, MD

Abstract: Oncogenes and their possible role in malignancy are reviewed under the following headings: acute transforming retroviruses, assignment of a normal function to a proto-oncogene (the transforming gene of simian sarcoma virus; the structure of human platelet-derived growth factor (PDGF); the v-sis gene product is structurally and immunologically related to PDGF), specific proto-oncogene rearrangements in human tumors, proto-oncogene amplification in tumor cells, DNA insertion can lead to oncogene activation, oncogenes demonstrated by transfection of human tumor DNA, and point mutations are responsible for activation of ras oncogenes. The number of genetic alterations required for neoplastic transformation remains to be elucidated. There is a great likelihood that not all of the proto-oncogenes capable of being activated as oncogenes have been discovered. Moreover, genetically predisposing states certainly exist but likely involve recessive alterations whose effects are more subtle than that of the germ line transmission of an activated oncogene. The few genes that already have been identified as targets of the neoplastic process are highly conserved and in their unaltered state almost certainly are involved in essential growth processes. (90 Refs)
Keywords: Animal *Cell Transformation, Neoplastic Cell Transformation, Viral Chromosome Aberrations Chromosome Mapping DNA Insertion Elements DNA, Neoplasm/GENETICS Gene Amplification Human Mutation Neoplasms/GENETICS *Oncogenes Platelet-Derived Growth Factor/GENETICS Proto-Oncogenes Retroviridae/*GENETICS Sarcoma Viruses, Simian/GENETICS Virus Activation MONOGRAPH

KWDanimalKWDcelltransformation,neoplasticcelltransformation,viralchromosomeaberrationschromosomemappingdnainsertionelementsdna,neoplasm/geneticsgeneamplificationhumanmutationneoplasms/geneticsKWDoncogenesplatelet-derivedgrowthfactor/geneticsproto-oncogenesretroviridae/KWDgeneticssarcomaviruses,simian/geneticsvirusactivationmonograph
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M8730286

Copyright © 1987 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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