EXPRESSION OF LYMPHOCYTE DIFFERENTIATION ANTIGENS IN IMMUNODEFICIENCY DISEASES

Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

EXPRESSION OF LYMPHOCYTE DIFFERENTIATION ANTIGENS IN IMMUNODEFICIENCY DISEASES

Leukocyte Typing II; 2:79-86 1986. Unique Identifier : AIDSLINE ICDB/87626847
Tedder TF; Clement LT; Crain MJ; Cooper MD; Cellular Immunobiology Unit, Tumor Inst., Univ. of Alabama,; Birmingham, AL 35294

Abstract: T and B cell differentiation was examined in patients (pts) with common variable immunodeficiency (CVI, 16 pts), selective IgA deficiency (IgA-, 4 pts), X-linked agammaglobulinemia (XLA, 5 pts), and acquired immunodeficiency syndrome (AIDS, 5 pts) using monoclonal antibodies to four lymphocyte differentiation antigens. Antibodies employed were HB-4 (identifies a subpopulation of resting B cells); HB-5 (reacts with the C3d receptor present on mature B cells); HB-7 (identifies immature B lymphocytes); and HB-10 (reacts with virgin, but not activated or memory, T cells). B cells from all four IgA- pts had normal phenotypic profiles. B cell maturation in CVI pts was heterogeneous; cells from 11/16 pts had normal antigenic phenotypes, whereas those from four CVI pts had normal HB-5 and HB-7 antigen expression but rarely expressed the HB-4 antigen, suggesting they were preactivated. One CVI pt's B cells were of immature phenotype. The vast majority of the limited numbers of IgM B cells from the XLA pts expressed the immature HB-4-, 5-, 7+ phenotype. B cells from AIDS pts were mostly HB-7-, with variable expression of the HB-4 antigen and significantly decreased expression of the HB-5 antigen. Although T cells from IgA- and most CVI pts had normal HB-10 antigen expression, T cells from five CVI pts and most AIDS pts appeared to be activated. In contrast, the circulating T cell population in XLA pts phenotypically resembled that of normal newborns. (14 Refs)

Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY Agammaglobulinemia/IMMUNOLOGY Antibodies, Monoclonal/IMMUNOLOGY Antibody Specificity Antigenic Determinants/IMMUNOLOGY Antigens, Surface/*IMMUNOLOGY B-Lymphocytes/*IMMUNOLOGY Dysgammaglobulinemia/IMMUNOLOGY Human IgA/DEFICIENCY Immunoglobulins/ANALYSIS Immunologic Deficiency Syndromes/*IMMUNOLOGY Monocytes/IMMUNOLOGY T-Lymphocytes/*IMMUNOLOGY MEETING PAPER

870330
M8730284

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1987. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1987. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .