Serum histidine-rich glycoprotein levels are decreased in acquired immune deficiency syndrome and by steroid therapy. NLM AIDSLINE Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

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Serum histidine-rich glycoprotein levels are decreased in acquired immune deficiency syndrome and by steroid therapy.

Biochem Med Metab Biol. 1986 Oct;36(2):210-3. Unique Identifier : AIDSLINE MED/87049262
Morgan WT

Abstract: Using radial immunodiffusion serum histidine-rich glycoprotein (HRG) levels were measured in acquired immune deficiency syndrome (AIDS) patients, in end-stage renal disease (ESRD) patients after renal transplantation and immunosuppressive steroid therapy, and in asthma and chronic obstructive pulmonary disease (COPD) patients treated with steroids. Compared with controls (12.5 +/- 3.0 mg/dl), HRG levels were significantly decreased in patients with AIDS (5.7 +/- 1.8 mg/dl, P less than 0.005): in patients with ESRD after renal transplantation with steroid therapy (4.4 +/- 1.1 mg/dl, P less than 0.005); and in asthmatic and COPD patients receiving steroids in acute (7.6 +/- 2.9 mg/dl, P less than 0.005) or chronic (7.4 +/- 3.0 mg/dl, P less than 0.025) high-dose regimens. In contrast, levels of hemopexin, another serum glycoprotein synthesized by the liver, were not lowered in these patients. These results show that serum HRG levels are selectively decreased in AIDS and in patients treated with immunosuppressive steroids.
Keywords: Acquired Immunodeficiency Syndrome/*BLOOD Asthma/BLOOD *Blood Proteins Glucocorticoids/*THERAPEUTIC USE Glycoproteins/*BLOOD Hemopexin/METABOLISM Human Kidney Failure, Chronic/BLOOD/THERAPY Lung Diseases, Obstructive/BLOOD/DRUG THERAPY Male Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDbloodasthma/bloodKWDbloodproteinsglucocorticoids/KWDtherapeuticuseglycoproteins/KWDbloodhemopexin/metabolismhumankidneyfailure,chronic/blood/therapylungdiseases,obstructive/blood/drugtherapymalesupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
870330
M8730264

Copyright © 1987 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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