Oral desensitization to trimethoprim-sulfamethoxazole in a patient with acquired immunodeficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

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Oral desensitization to trimethoprim-sulfamethoxazole in a patient with acquired immunodeficiency syndrome.

J Allergy Clin Immunol. 1986 Nov;78(5 Pt 1):905-8. Unique Identifier : AIDSLINE MED/87058575
Finegold I

Abstract: Intravenous administration of trimethoprim-sulfamethoxazole (TMS) on three occasions resulted in fever, rash, and wheezing in a 30-year-old man with acquired immunodeficiency syndrome with Pneumocytis carinii pneumonia. Pentamidine administration produced fever, severe myositis, and clinical deterioration, and therefore, desensitization to TMS was attempted. This was done with low doses of oral suspension and then intravenous administration during a period of 60 hours. The patient reacted with fevers, arthralgia, and erythema that cleared 4 days after the desensitization was completed. This single case of successful desensitization to TMS in a patient with acquired immunodeficiency syndrome suggests that the oral route may be useful in similar situations when this drug is urgently needed.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Adult Case Report Drug Hypersensitivity/*THERAPY Human Male Sulfamethoxazole/*IMMUNOLOGY Trimethoprim/*IMMUNOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDimmunologyadultcasereportdrughypersensitivity/KWDtherapyhumanmalesulfamethoxazole/KWDimmunologytrimethoprim/KWDimmunologyjournalarticle
870330
M8730241

Copyright © 1987 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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