Myelodysplasia progressing to acute myeloblastic leukemia in an HTLV-III virus-positive homosexual man with AIDS-related complex. NLM AIDSLINE Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

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Myelodysplasia progressing to acute myeloblastic leukemia in an HTLV-III virus-positive homosexual man with AIDS-related complex.

Am J Clin Pathol. 1986 Dec;86(6):788-91. Unique Identifier : AIDSLINE MED/87073280
Napoli VM; Stein SF; Spira TJ; Raskin D

Abstract: Myelodysplastic changes have recently been described in patients with the acquired immunodeficiency syndrome (AIDS). The authors report a patient with AIDS-related complex and myelodysplasia who rapidly progressed to acute myeloblastic leukemia. Infection with human T-cell lymphotropic virus type III (HTLV-III) was documented by culture and by serology. Chromosome studies showed monosomy of chromosome 7 and structural abnormality of the long arm of chromosome 3. The association of HTLV-III infection with myelodysplasia and acute myeloblastic leukemia may have been coincidental in this reported case, but it is also possible that the leukemia was secondary to the HTLV-III infection. Further investigation appears justified.
Keywords: Adult AIDS-Related Complex/*COMPLICATIONS/MICROBIOLOGY Case Report *Homosexuality Human HIV/*ISOLATION & PURIF Leukemia, Myelocytic, Acute/*ETIOLOGY Male Myelodysplastic Syndromes/*COMPLICATIONS JOURNAL ARTICLE

KWDadultaids-relatedcomplex/KWDcomplications/microbiologycasereportKWDhomosexualityhumanhiv/KWDisolation&purifleukemia,myelocytic,acute/KWDetiologymalemyelodysplasticsyndromes/KWDcomplicationsjournalarticle
870330
M8730133

Copyright © 1987 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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