Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.
RECENT ADVANCES IN PRIMARY AND ACQUIRED IMMUNODEFICIENCIES
Serono Symp Publ Raven Press; 28:1-434 1986. Unique Identifier : AIDSLINE ICDB/87630101 Anonymous; No affiliation given
Abstract:
Articles describing recent advances in primary and acquired immunodeficiencies are presented under six sections, namely, (I) ontogeny and activation of T and B cells, (II) lymphokines, (III) membrane defects, (IV) immunobiology of immunodeficiencies, (V) acquired immunodeficiency syndrome (AIDS), and (VI) immunotherapy of immunodeficiencies. Those in Section I have the following titles: ontogeny of human T cells: acquisition of a functional program; activation and regulation of T lymphocytes in vivo; ontogeny of B cells, and their abnormal development in immunodeficiency diseases; regulation of B cell responses; a new, X-chromosomal gene family (XLR) expressed in mature lymphoid cells; role of ion channels in the activation of T lymphocytes; role of calcium on gamma interferon production; and requirements for the human T cell response to antigen. Those under Section II have the titles: molecular genetic analysis of T-cell antigen and interleukin-2 receptors on normal and leukemic lymphocytes; modulation of T cell activation by lymphokines and other biologically active compounds; peripheral immunodeficiency associated with experimental arthritic disease in rats; immunoregulatory activity of thymosin alpha-1; and the role of thymic hormones in regulating T cell activity and lymphokine production. Those under Section III have the titles: characterization of phagocytic abnormalities in patients who have an inherited deficiency of neutrophil; and the importance of the Mac-1, LFA-1 glycoprotein family in monocyte and granulocyte adherence, chemotaxis, and migration into the inflammatory sites. Those under Section IV have the titles: immune responses to poliovirus by lymphocytes from antibody deficient patients; abnormalities of T cell subsets and lymphokines in immunodeficiencies; lymphocyte abnormalities in patients with IgG subclass deficiency; defective synthesis of HLA class I and II molecules associated with a combined immunodeficiency; congenital agammaglobulinemia associated with malabsorption; DNA-mediated gene transfer into ataxia-telangiectasia cells; instability of the immunoglobulin coding region in a patient with ataxia-telangiectasia, T-cell leukemia, and chromosome 14 translocation; the molecular basis of Ig deficiencies; assessment of the humoral immune response in immunodeficiencies; abnormalities of humoral immunity resulting from immunoregulatory T-cell dysfunction; and ontogeny of T cell subsets in the neonatal period. Those under Section V have these titles: immune deregulation in the lymphadenopathy syndrome; immunologic abnormalities in AIDS; biology and seroepidemiology of HTLV-III; seropositivity to HTLV-III/LAV in Danish subpopulations; a 2-yr immunological survey of hemophiliacs from Apulia, Italy; and epidemiological survey on HTLV-III infection in Italy: 1981-1985. Those under Section VI have these titles: bone marrow transplantation in 1985; adverse reactions to iv immunoglobulins; subtle, antigen-selective T-cell defects as a cause of relapsing purulent infections of the upper respiratory tract; participation of the cellular immunologic system in the Duchenne muscular dystrophy; improvement of T-cell percentage in old people after thymostimulin therapy; and longitudinal assessment of lymphocyte subpopulations in patients with squamous cell carcinoma of head and neck.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Animal Antibody Formation Human Immunity, Cellular Immunologic Deficiency Syndromes/*IMMUNOLOGY MONOGRAPH
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Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.
