Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.
IMMUNE DEREGULATION IN THE LYMPHADENOPATHY SYNDROME
Serono Symp Publ Raven Press; 28:257-67 1986. Unique Identifier : AIDSLINE ICDB/87630116 Cunningham-Rundles S; Metroka C; Schneider J; Campbell H; Gold J; Hayward G; Safai B; Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New; York, NY 10021
Abstract:
The acquired immunodeficiency disease syndrome (AIDS) is characterized by opportunistic infections and/or the appearance of a rare tumor, Kaposi's sarcoma (KS). Since KS is known to develop in states of transient immunocompromise, such as prophylactic immunosuppression in renal transplantation, and to resolve with return of immunocompetence, its appearance in AIDS suggested a central role for immune deregulation in the pathogenesis. Among the populations of individuals considered to be at risk of AIDS as a result of lifestyle factors, homosexual men with generalized lymphadenopathy (LA) syndrome constitute a relatively homogeneous group. The authors originally reported that 17% of their group of 90 LA patients developed AIDS during the 8- to 19-mo follow-up period. In this population, a subset of patients with markedly depressed lymphocyte response in vitro to phytohemagglutinin and pokeweed mitogen and with negative responses to E coli, C albicans, and S aureus were observed; of 17 such patients identified, 70% developed AIDS during the observation period. The microbial activators were found to be the most sensitive pre-AIDS marker in this population. Since these agents activate B cells, this suggested that residual B cell function might prove a critical discriminator for the identification of patients with greater or lesser resistance to AIDS. Furthermore, the authors and others have found that approx 10% of LA patients develop B cell lymphomas, suggesting that this group of patients might provide a link between HTLV-III retroviral infection of T cells and B cell malignancies. The immunological characteristics of LA patients are presented, and some preliminary indications that B cell deregulation is central to LA etiology are discussed under the following section headings: analysis of lymphocyte activation in AIDS and the LA syndrome, coculture suppression of normal lymphocyte response, restoration of immune response in vitro by immunomodulation, and cytotoxicity in AIDS and the LA syndrome. (17 Refs)
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY AIDS-Related Complex/*IMMUNOLOGY B-Lymphocytes/IMMUNOLOGY Cell Line Cell Transformation, Neoplastic/IMMUNOLOGY Cytotoxicity, Immunologic Human Interleukin-2/BIOSYNTHESIS Lymphocyte Transformation Sarcoma, Kaposi's/IMMUNOLOGY Skin Neoplasms/IMMUNOLOGY T-Lymphocytes, Helper-Inducer/IMMUNOLOGY T-Lymphocytes, Suppressor-Effector/IMMUNOLOGY MEETING PAPER
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Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.
