Plasma protein alterations in AIDS and hemophilia A. NLM AIDSLINE Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

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Plasma protein alterations in AIDS and hemophilia A.

AIDS Res. 1986 Fall;2(4):309-19. Unique Identifier : AIDSLINE MED/87128378
Dayal VK; Lea MA; Arkel YS

Abstract: Plasma proteins of patients with AIDS, ARC, hemophilia A, and some viral infections were studied using various electrophoretic techniques, and compared to healthy control subjects. On isoelectric focusing (IEF) gels the most prominent and consistent finding was a marked increase in a basic protein band (AABP) at pI approximately equal to 9.0 in plasma samples derived from AIDS and hemophilia A patients. Using SDS gels, we noted an increased amount of protein in the 90 KD region in AIDS patients as compared to control subjects. On two dimensional gels (2D gels) basic protein(s) with pI congruent to 8.1-9.0 and molecular weight of approximately 90 KD were noted to be increased. In addition, a basic protein of 27 KD along with two acidic proteins in the low molecular weight region were also elevated in AIDS plasma. Although a limited number of samples were analyzed, it seems probable that a number of proteins are altered in AIDS plasma. AABP stained positive with periodic acid Schiff (PAS) reagent, indicating that it is a glycoprotein. This protein did not bind to an anti-IgG sepharose column, suggesting that it is not an immunoglobulin. The purified protein also did not react with antibody to fibrinogen and hemoglobin beta-chain. There are many changes in the plasma protein pattern of AIDS and hemophilia A patients as compared to normal controls.
Keywords: Acquired Immunodeficiency Syndrome/*BLOOD Blood Protein Electrophoresis Blood Proteins/*ANALYSIS Hemophilia/*BLOOD Human Isoelectric Focusing Support, Non-U.S. Gov't JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDbloodbloodproteinelectrophoresisbloodproteins/KWDanalysishemophilia/KWDbloodhumanisoelectricfocusingsupport,non-uKWDsKWDgov'tjournalarticle
870630
M8760410

Copyright © 1987 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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