[Suppression of phagocyte function by seminal plasma: possible predisposition for AIDS] NLM AIDSLINE Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

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[Suppression of phagocyte function by seminal plasma: possible predisposition for AIDS]

Hautarzt. 1986 Dec;37(12):656-61. Unique Identifier : AIDSLINE MED/87136589
Schopf RE; Trompeter M; Benes P; Morsches B; Schramm P

Abstract: A pathogenic retrovirus (HTLV-III) has recently been isolated in the seminal plasma (SP) of patients with AIDS. In order to test whether SP may influence non-specific immunity we compared the influence of SP on the phagocytic release of lysozyme, chemotaxis and chemiluminescence. SP inhibited the release of lysozyme from granulocytes in a log-linear fashion; incubation with undiluted SP resulted in about 50% inhibition. Chemotaxis of granulocytes remained stable under the influence of SP. Chemiluminescence of both granulocytes and monocytes was completely blocked by undiluted SP; 1000-fold dilutions still caused an inhibition of about 20%. The separation of SP by column chromatography yielded fractions with a molecular weight of 10(4) to 2 X 10(4), 10(5) to 4 X 10(5) and greater than 10(6) inhibiting chemiluminescence. A cell-free chemiluminescent system showed the reduction of chemiluminescence to be based to a large extent on quenching of the photons generated. Our results indicate that SP possesses potent properties that suppress non-specific immunity, possibly an important predisposing factor to AIDS.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Chemotaxis, Leukocyte English Abstract Granulocytes/IMMUNOLOGY Human Immune Tolerance Leukocytes/IMMUNOLOGY Luminescence Male Muramidase/METABOLISM Phagocytes/IMMUNOLOGY *Phagocytosis Semen/*IMMUNOLOGY Support, Non-U.S. Gov't JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDimmunologychemotaxis,leukocyteenglishabstractgranulocytes/immunologyhumanimmunetoleranceleukocytes/immunologyluminescencemalemuramidase/metabolismphagocytes/immunologyKWDphagocytosissemen/KWDimmunologysupport,non-uKWDsKWDgov'tjournalarticle
870630
M8760386

Copyright © 1987 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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