Articles describing recent advances in primary and acquired immunodeficiencies are presented under six sections, namely, (I) ontogeny and activation of T and B cells, (II) lymphokines, (III) membrane defects, (IV) immunobiology of immunodeficiencies, (V) acquired immunodeficiency syndrome (AIDS), and (VI) immunotherap
Cunningham-Rundles S; Metroka C; Schneider J; Campbell H; Gold J; Hayward G; Safai B; Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New; York, NY 10021
The acquired immunodeficiency disease syndrome (AIDS) is characterized by opportunistic infections and/or the appearance of a rare tumor, Kaposi s sarcoma (KS). Since KS is known to develop in states of transient immunocompromise, such as prophylactic immunosuppression in renal transplantation, and to resolve with ret
Indian Society of Oncology. 2nd Biennial Conference. February 9-14, 1986, Bombay, India. Abstracts of Conference Lectures, p. 1-19, 1986.. Unique Identifier : AIDSLINE ICDB/87630262
Anonymous; No affiliation given
Abstracts of the following conference lectures at the 2nd Biennial Conference of the Indian Society of Oncology held in Bombay, India, 9-14 February, 1986, are presented: organization of a comprehensive cancer center; bone marrow transplantation in India: feasibility and limitations; perspective of cancer research in
Alumbaugh MJ; California School of Professional Psychology
This study examined the social support and coping of individuals with Auto Immune Deficiency Syndrome (AIDS). Fifty men were recruited from the AIDS outpatient clinic, Department of Immunology/Oncology at UCLA. Data gathered by self report questionnaire included sociodemographics, self esteem, attitudes toward homosex
AIDS Res. 1986 Fall;2(4):285-8. Unique Identifier : AIDSLINE MED/87128375
Sindrup JH; Weismann K; Wantzin GL
Out of 100 male homosexual persons screened for AIDS, 54 were found to be HTLV-III antibody positive. Of these, 34 (63%) had a positive history of syphilis, as compared to 16 (35%) of the 46 HTLV-III antibody negative persons (P less than 0.01). In the HTLV-III antibody positive group 12 (22%) had had more than three
AIDS Res. 1986 Fall;2(4):289-98. Unique Identifier : AIDSLINE MED/87128376
Wicher V; Wicher K
NZ rabbits were treated with various combinations of enemas and intrarectal insemination (1 or 3 ml of semen a week) to investigate the effects of intestinal uptake and immunogenicity of seminal components and of an unrelated antigen, bovine serum albumin (BSA), given simultaneously. For 5 months the treatment was lim
AIDS Res. 1986 Fall;2(4):309-19. Unique Identifier : AIDSLINE MED/87128378
Dayal VK; Lea MA; Arkel YS
Plasma proteins of patients with AIDS, ARC, hemophilia A, and some viral infections were studied using various electrophoretic techniques, and compared to healthy control subjects. On isoelectric focusing (IEF) gels the most prominent and consistent finding was a marked increase in a basic protein band (AABP) at pI ap
AIDS Res. 1986 Fall;2(4):325-34. Unique Identifier : AIDSLINE MED/87128380
Tirelli U; Vaccher E; Carbone A; Diodato S; Sorio R; Bosio R; Tamburlini R; Crotti D; Crovatto M; De Paoli P; et al
Seroepidemiological, clinical, immunological, and pathological features were studied in 315 intravenous drug abusers (IVDA) seen in five centers for drug addicts assistance in the Friuli Venezia-Giulia region of Italy , close to the borders of Austr
AIDS Res. 1986 Fall;2(4):335-42. Unique Identifier : AIDSLINE MED/87128381
Cabral CM; Sen L; Palacios MF; Muchinik G; Maero EB; Scaglione C; Estevez ME
We investigated the distribution of autologous rosette forming cells (ARFC) in the peripheral blood from subjects at risk for the acquired immunodeficiency syndrome (AIDS). The mean percentage of ARFC with autologous plasma from 35 male homosexual individuals was significantly lower than that of 31 normal controls. Th
AIDS Res. 1986 Fall;2(4):357-61. Unique Identifier : AIDSLINE MED/87128384
Calabrese LH; Harris B; Easley KA; Proffitt MR
A survey of 305 homosexual men was performed in an area of relatively low incidence for AIDS and low seroprevalence for antibody to the human immunodeficiency virus (HIV). The objective of the study was to investigate current knowledge and practice of sexual behavior designed to limit transmission of HIV. The results
Ann Pathol. 1986;6(4-5):275-7. Unique Identifier : AIDSLINE MED/87128392
Le Tourneau A; Audouin J; Diebold J
The identification of viral particles in the lymph node germinative centers from patients at risk for AIDS is an important diagnostic factor in the prodromal stages of this illness. Those particles are solely seen between the cytoplasmic extensions of the dendritic reticular cells. They have the same morphology than L
Ann Pathol. 1986;6(4-5):278-81. Unique Identifier : AIDSLINE MED/87128393
Raphael M; Tulliez M; Bellefqih S; Louvel A; Ziza JM; Rozenbaum W; Sicard D; Dreyfus F; Picard F; Foncin JF; et al
We report 21 cases of lymphomas associated with AIDS. Sixteen cases are Non Hodgkin s lymphomas of high grade malignancy. Immunoblastic B cell lymphomas are frequent: 11 cases/16, especially with extra nodal localisations. Three cases are Burkitt s lymphoma; 2 cases are large non cleaved cell lymphoma. Five cases of H
Ann Pathol. 1986;6(4-5):282-6. Unique Identifier : AIDSLINE MED/87128394
Marche C; Zoubi D; Rene E; Girard PM
The histopathological study of the digestive mucosae has a great diagnostic value. It appreciates lymphoid tissue; it may suggest AIDS when it discloses rare inflammatory or tumoral lesions; it may disclose an infectious and/or Kaposi sarcoma lesion which may be the first manifestation of AIDS in a seropositive LAV pa
Ann Pathol. 1986;6(4-5):287-91. Unique Identifier : AIDSLINE MED/87128395
Marche C; Zoubi D; Michon C
We believe it is important to underscore: The frequency and variety of the lesions, mainly within the liver but also of the biliary tract and the pancreas, which may reveal an inaugural complication of AIDS. The interest of the vascular lesions, mainly of the sinusoids as well as the various associated lesions due to
Ann Pathol. 1986;6(4-5):297-9. Unique Identifier : AIDSLINE MED/87128397
Lessana-Leibowitch M; Choudat L
Kaposi s sarcoma in AIDS syndrome differs in many ways from the typical nodular lesions observed in older patients. Clinical lesions are usually multiple with no predilection for the lower extremities; they usually present as small macules or patches with little or no infiltration, pink rather than deeply violaceous;
Ann Pathol. 1986;6(4-5):300-4. Unique Identifier : AIDSLINE MED/87128398
Nezelof C; Roth A; Blanche S; Barbey S
The anatomo-clinical investigation of a series of 12 cases of AIDS in infants, over two years in Hopital des Enfants Malades (Paris) allows the following observations to be made: the frequency of materno-foetal contaminations (8/12); the relative shortness of the incubation period (3-6 months); the variable degree of
Although radiotherapy is a standard form of management of head and neck tumors, treatment of the oral cavity in patients who have the acquired immunodeficiency syndrome has produced unacceptable toxicity. Five such patients are described as a warning of enhanced toxicity of oral radiotherapy in this patient population
Aust N Z J Ophthalmol. 1986 Nov;14(4):287-91. Unique Identifier : AIDSLINE MED/87128607
Woods SL; Wakefield D; McCluskey P
The acquired immune deficiency syndrome (AIDS) is characterised by a loss of normal cellular immunity in affected individuals which predisposes them to severe opportunistic infections and neoplasms. These pathological processes may affect the eye, and ocular involvement with an opportunistic infection or malignancy ma
Katzman M; Carey JT; Elmets CA; Jacobs GH; Lederman MM
We report here the clinical and immunological findings in two patients with molluscum contagiosum poxvirus infection and the acquired immunodeficiency syndrome (AIDS). These cases support earlier evidence that the molluscum contagiosum virus may act as cases support earlier evidence that the molluscum contagiosum viru
Mann JM; Altus CS; Webber CA; Smith PR; Muto R; Heurich AE
Thirty patients known to have or suspected of having acquired immunodeficiency syndrome (AIDS) were evaluated for opportunistic pulmonary infection using a double lumen lavage catheter (DLL). Lavage specimens obtained were cytocentrifuged and initially stained by the Papanicolaou technique as a means of rapid evaluati
Pleural cryptococcosis is extremely rare. We report the first case of cryptococcal pleural effusion in association with the acquired immune deficiency syndrome. Pleural effusion without the evidence of pulmonary parenchymal involvement was the initial and only clinical finding leading to the diagnosis of disseminated
Dtsch Med Wochenschr. 1987 Mar 6;112(10):378-81. Unique Identifier : AIDSLINE MED/87133071
Just G; Neisel F; Helm EB; Brodt HR; Stumer S; Stille W
Investigations for cryptosporidia were carried out on 250 fecal samples from 131 HIV-positive patients between December 1985 and July 1986 with kinyoun carbolfuchsin staining. Cryptosporidial oocysts could be detected in six homosexual men. All of the cryptosporidia excretors had symptoms of enteritis. The clinical co
Sepsis, peritonitis, and gastroenteritis developed in a 45-yr-old homosexual man 1 day after ingestion of raw oysters. The patient had chronic active hepatitis and cirrhosis with hepatitis B virus and delta-infection. He also had persistent generalized lymphadenopathy associated with HTLV-III antibody positivity. Vibr
Gen Hosp Psychiatry. 1987 Jan;9(1):11-7. Unique Identifier : AIDSLINE MED/87134962
Agle D; Gluck H; Pierce GF
The psychologic impact of the risk of the acquired immune deficiency syndrome (AIDS) was evaluated by questionnaire survey of 116 hemophiliacs, age 16 or older, and 40 mates and 94 parents of hemophiliacs. Although the mean group distress ratings indicate a lessening of emotional discomfort over time, ongoing distress
Gen Hosp Psychiatry. 1987 Jan;9(1):58-63. Unique Identifier : AIDSLINE MED/87134969
Blumenfield M; Smith PJ; Milazzo J; Seropian S; Wormser GP
This article reports the results of a ten-question anonymous survey given to nurses at Westchester County Medical Center in July 1983 and January 1984 concerning attitudes about caring for AIDS patients. Two-thirds of the responding nurses reported that they had friends or family express concern about associating with
Schopf RE; Trompeter M; Benes P; Morsches B; Schramm P
A pathogenic retrovirus (HTLV-III) has recently been isolated in the seminal plasma (SP) of patients with AIDS. In order to test whether SP may influence non-specific immunity we compared the influence of SP on the phagocytic release of lysozyme, chemotaxis and chemiluminescence. SP inhibited the release of lysozyme f
A large number of patients with acquired immune deficiency syndrome develop disseminated infections due to member serotypes of the Mycobacterium avium complex. Seroagglutination on 181 such isolates followed by enzyme-linked immunosorbent assay and thin layer chromatography of the type-specific glycopeptidolipid (GPL)
Five patients known to be HIV (human immunodeficiency virus)-positive--that is, susceptible to AIDS--presented with symptoms initially thought to be indicative of lumbar disc lesions. Signs of nerve root or cauda equina compression were found in all five patients. Lumbar radiculography and, in one patient, computerise
A patient with acquired immunodeficiency syndrome presented with multiple pruritic papules and nodules over the trunk and extremities. Biopsy specimens from two of these lesions contained granules within abscesses of the papillary dermis. There were numerous gram-positive cocci within the granules. Culture of one lesi
Management of patients with acquired immunodeficiency syndrome (AIDS) is complicated by a high frequency of adverse drug reactions to trimethoprim-sulfamethoxazole and pentamidine. Because of the lack of suitable alternative antiparasitic drugs, some patients who have experienced previous allergic-type reactions to an
The authors describe a case of retinopathy in a patient suffering from AIDS. A study of the Fundus of a 25 year-old homosexual and drug-addict suffering from AIDS revealed cotton wool spots and edema of the optic disc in both eyes. In this paper the authors reports increased lesions of the retina with the progression
Epidermal dendritic cells (Langerhans cells) present cutaneously derived antigens to T cells in the skin and draining lymph nodes and therefore are important in many afferent immune responses. The role of dermal dendritic cells on the other hand is more obscure, although it has been suggested that these cells are prec
The generation of CL by phagocytes has been shown to be a valuable tool for monitoring the activity of phagocytic cells. It has been used to investigate mechanisms by which stimulants or inhibitors act to affect the function of phagocytic cells. CL has also been used as an assay system to detect various disease states
Nature. 1987 Mar 12-18;326(6109):137-42. Unique Identifier : AIDSLINE MED/87144632
May RM; Anderson RM
Simple mathematical models of the transmission dynamics of human immunodeficiency virus help to clarify some of the essential relations between epidemiological factors, such as distributed incubation periods and heterogeneity in sexual activity, and the overall pattern of the AIDS epidemic. They also help to identify
Thirty-four children have been cared for at SUNY-Health Science Center at Brooklyn with diagnoses of either acquired immunodeficiency syndrome (AIDS) or AIDS-related complex. Reported here are descriptions of pregnancies resulting in these children. Few of the mothers (four of 32) were symptomatic; however, low birth
Although several hundred cases of acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC) in infants have been reported, there is little information available concerning the follow-up of mothers and these children or subsequently born children. Thirty-four children with perinatally acquired AIDS and A
Am Fam Physician. 1987 Mar;35(3):109-16. Unique Identifier : AIDSLINE MED/87152985
Frierson RL; Lippmann SB
Eleven patients with AIDS were seen by a psychiatric consultation service over a four-year period. Psychologic issues identified in these patients included changes in body image, feelings of helplessness and isolation, sexual concerns and the grief process. Management should be aimed toward maintaining a nonjudgmental
Lymphocyte subpopulations in the intestinal tissues of seven patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) were studied by immunohistologic technics at two different locations, the small bowel and the rectum. Intraepithelial and lamina propria lymphocyte subsets stained with mon
This report describes a 38-year-old male homosexual with acquired immune deficiency syndrome (AIDS) and a history of Isospora belli infestation treated with trimethoprim-sulfamethoxazole. At autopsy, intracellular and extracellular I. belli organisms were identified in the mucosa and lamina propria of small and large
To assess the spectrum of hepatic abnormalities in acquired immune deficiency syndrome (AIDS), we reviewed clinical, biochemical, and pathological material in 32 patients with AIDS. Eight-four percent of AIDS cases had a history of intravenous drug abuse. Ninety percent of AIDS patients has some liver biochemical abno
Thymic epithelial fragments were transplanted into 15 patients in an advanced stage of the acquired immunodeficiency syndrome (AIDS). One patient was given interleukin 2 in addition to thymic tissue. We demonstrated the following: Thymic epithelial fragments cultured before transplantation to remove T cells survived f
The first case, to our knowledge, of an integumentary form of botryomycosis is reported in a homosexual man with acquired immunodeficiency syndrome. Anal fistula and ischiorectal and gluteal abscesses developed following severe cryptosporidial diarrhea. Grains composed of gram-positive cocci were identified in the sup
Cell. 1987 Feb 27;48(4):691-701. Unique Identifier : AIDSLINE GENBANK/K03455
Muesing MA; Smith DH; Capon DJ
HIV LTR-directed expression is markedly stimulated in trans by coexpression of a region of the HIV genome encoding a portion of the tat reading frame. Transient expression assay analysis reveals that trans-activation of LTR-directed expression results primarily from an increase in mRNA accumulation. Deletion analysis
Health Soc Work. 1987 Winter;12(1):5-11. Unique Identifier : AIDSLINE MED/87135275
Buckingham SL; Rehm SJ
Because acquired immune deficiency syndrome (AIDS) has often been perceived as a disease of gay men, little attention has been given to the increasing number of women exposed to AIDS. An overview of the disease reveals that its victims confront both physical and psychosocial problems of great complexity and that socia
Negative staining electron microscopy was used to examine culture fluids from the H9/HTLV-III cell line after concentration by centrifugation. Characteristic retrovirus-like particles bearing distinctive envelope projections were seen. The virion envelope was frequently extended in the form of a bleb or a tail. These
Chiodi F; Fuerstenberg S; Gidlund M; Asjo B; Fenyo EM
A malignant glioma cell line was infected with the human T-lymphotropic virus type IIIB isolate of the human immunodeficiency virus. Infection appeared to be latent rather than productive. Through contact with monocytic or lymphoid cells, the virus present in the glioma cells could be transmitted and gave rise to a fu
Fifty-nine lymph node biopsies from homosexual men with serum antibodies to HTLV-III/LAV were the subject of a detailed histopathological and immunohistochemical study. The histological findings were correlated to the patients clinical status, and the T4/T8 ratios in blood and lymph nodes. Four histological patterns p
Am J Med. 1987 Mar;82(3):553-6. Unique Identifier : AIDSLINE MED/87153428
Resnick L; Pitchenik AE; Fisher E; Croney R
Lymphocytic interstitial pneumonitis, a disorder of unknown cause, has been described in association with infection by the retrovirus human T lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). This report describes the isolation of HTLV-III/LAV in bronchoalveolar lavage fluid and the quantita
Chung Hua Min Kuo Wei Sheng Wu Chi Mien I Hsueh Tsa Chih. 1986 Feb;19(1):7-17. Unique Identifier : AIDSLINE MED/87132603
Wang GR; Lin KT; Liu MF; Shieh CC; Shih LY; Lian DC; Lin TT; Chen CS; Chang SA
A total of 2321 serum samples were collected from a variety of AIDS risk groups. The samples were tested for anti-HTLV-III using ELISA. Low prevalences of seropositivity were detected in the high-risk groups. Among 120 homosexuals/bisexuals, one seropositive suffering from full-blown AIDS was an American traveler. Ano
A study of 304 sexually active homosexual men, most of whom had multiple casual partners, showed that receptive anogenital intercourse, independent of anal bleeding, was the only risk factor for HTLV-III/LAV transmission. There was no evidence that HTLV-III/LAV infection, measured by seropositivity, was transmitted by
When Vero or murine cells were stably transfected with the human immunodeficiency virus (HIV) long terminal repeat (LTR) that directs the chloramphenicol acetyltransferase (CAT) gene (pU3R-III-CAT), expression was suppressed. Treatment with the nucleoside analog 5-azacytidine (5-azaC) restored CAT expression. S1 nucle
Aust N Z J Med. 1986 Oct;16(5):686-90. Unique Identifier : AIDSLINE MED/87156360
Blacker P; Tindall B; Wodak A; Cooper D
A survey of a cohort of 200 intravenous (IV) drug users drawn from five drug referral agencies was conducted in Sydney in 1985 and revealed only one heterosexual male with antibodies to AIDS retrovirus (ARV). Contact tracing of sexual and needle-sharing partners resulted in the referral of a further four out of six at
AIDS Res. 1986 Fall;2(4):321-4. Unique Identifier : AIDSLINE MED/87128379
Sarkar TK; Gumaste VV
We evaluated the efficacy of bronchial brushings in detecting Pneumocystis carinii pneumonia (PCP) in patients with AIDS. Bronchial brushings were performed on 20 occasions in 15 patients. Nine of the 20 bronchial brushings were performed through an endotracheal tube without using a bronchoscope. Twelve of the 20 were
Three patients with severe Pneumocystis carinii pneumonia and acquired immunodeficiency syndrome, not responding to specific therapy with trimethoprim/sulfamethoxazole, were treated with a 24-hour course of high-dose methylprednisolone. Rapid improvements in the clinical status and the chest X-rays were detected. In t
Joshi VV; Kauffman S; Oleske JM; Fikrig S; Denny T; Gadol C; Lee E
Four cases of pediatric Acquired Immune Deficiency Syndrome (AIDS) with lymphoproliferative disorder are described and other lymphoid lesions in previously reported cases of pediatric AIDS are reviewed. The lymphoproliferative disorder was characterized by polyclonal, polymorphic B-cell content without evidence of cel
We reviewed the initial and follow-up chest roentgenograms (CXR) of 104 patients with the acquired immune deficiency syndrome (AIDS) and Pneumocystis carinii pneumonia (PCP) diagnosed between 1981 and 1985 in order to determine the relative frequencies of its various roentgenographic patterns. Although a diffuse bilat
We report a case of endobronchial Pneumocystis carinii infection in a patient who most likely had the acquired immune deficiency syndrome (AIDS). Although many unusual manifestations of Pneumocystis pneumonia have been reported in patients with AIDS, this is the first case of P carinii presenting as an endobronchial m
Grimes MM; LaPook JD; Bar MH; Wasserman HS; Dwork A
Pneumocystis carinii, a frequent cause of pneumonia in immunocompromised patients, rarely disseminates to involve other organs. This report describes a patient with acquired immunodeficiency syndrome and pneumocystis pneumonia in whom extrapulmonary P. carinii infection was diagnosed on duodenal and esophageal endosco
J Immunol. 1987 Mar 15;138(6):1719-23. Unique Identifier : AIDSLINE MED/87139201
Margolick JB; Volkman DJ; Folks TM; Fauci AS
Peripheral blood mononuclear cells (PBMNC) from healthy donors immune to the soluble antigens tetanus toxoid (TT) and/or keyhole limpet hemocyanin (KLH) were exposed to infectious human T lymphotropic virus, type III/lymphadenopathy-associated virus (HTLV-III/LAV) with and without prior activation by TT or KLH. After
Klein A; Bruser B; Robinson JB; Pinkerton PH; Malkin A
We have observed previously that the rate of cortisol catabolism by lymphocytes (CCL) was indicative of the vulnerability of these cells to cortisol. We attempted to ascertain whether cortisol-sensitive lymphocytes (e.g. thymocytes) metabolize cortisol at a different rate from cortisol-resistant cells and whether lymp
Proc Natl Acad Sci U S A. 1987 Feb;84(4):1055-9. Unique Identifier : AIDSLINE MED/87147191
Palmer TD; Hock RA; Osborne WR; Miller AD
Skin fibroblasts might be considered suitable recipients for therapeutic genes to cure several human genetic diseases; however, these cells are resistant to gene transfer by most methods. We have studied the ability of retroviral vectors to transfer genes into normal human diploid skin fibroblasts. Retroviruses carryi
The records of 63 patients with acquired immune deficiency syndrome (AIDS) and respiratory infection comprising 78 hospitalizations over a 36-month period were reviewed to ascertain the etiology of the respiratory infection and to identify the factors influencing short-term survival. Pneumocystis carinii pneumonia (PC
Survey about the actual situation of the epidemiology, diagnosis and therapy of STD. Results of the improvement of cultural diagnosis of gonorrhoe and of high dose treatment of syphilis are discussed intensively. Acquired immune deficiency syndrome (AIDS) is reviewed concerning clinical aspects.
Am J Med. 1987 Mar;82(3):389-96. Unique Identifier : AIDSLINE MED/87153402
Kaplan MH; Susin M; Pahwa SG; Fetten J; Allen SL; Lichtman S; Sarngadharan MG; Gallo RC
Neoplastic disease arose in 29 of 200 patients infected with human T lymphotropic virus type III (HTLV-III) seen at a suburban hospital. Seventeen patients had Kaposi s sarcoma, one of whom also had colon carcinoma. Nine patients had lymphoproliferative disorders (seven lymphomas, one T suppressor cell chronic lymphoc
Am J Med. 1987 Mar 23;82(3 Spec No):645-8. Unique Identifier : AIDSLINE MED/87153456
Hurley P; Weikel C; Temeles D; Rosenberg S; Pearson R
Pneumocystis carinii is a well-recognized cause of pneumonia in patients with immune deficiency, and when untreated, mortality approaches 100 percent. Although rare cases suggesting spontaneous recovery (usually accompanied by resolving immune deficiency) have been reported, spontaneous resolution of P. carinii pneumo
Am J Med. 1987 Mar 23;82(3 Spec No):655-61. Unique Identifier : AIDSLINE MED/87153458
Guillon JM; Fouret P; Mayaud C; Picard F; Raphael M; Touboul JL; Chaunu MP; Hauw JJ; Akoun G
Lymphocytic visceral infiltration has recently been noted in association with lymphadenopathy-associated virus infection. A homosexual man, who had clinical and immunologic features of the acquired immune deficiency syndrome (AIDS)-related complex, is described. The patient presented not only with peripheral blood lym
Five cases of Pneumocystis carinii infection with evidence of lung tissue destruction that occurred in patients with the acquired immunodeficiency syndrome were reviewed. None of the patients had a history of cigarette smoking, but all five had either cavitarylike lesions in the lungs or had pneumothorax at the time o
Guarner J; Brynes RK; Chan WC; Birdsong G; Hertzler G
We report two cases of primary cardiac lymphoma that developed in patients suffering from the acquired immunodeficiency syndrome. Both cases of lymphoma were histologically aggressive as generally observed in patients with the acquired immunodeficiency syndrome. The lymphoma cells in the center of a tumor nodule obtai
AIDS Res. 1986 Fall;2(4):279-83. Unique Identifier : AIDSLINE MED/87128374
Buimovici-Klein E; Ong KR; Lange M; Englard A; McKinley GF; Reddy M; Grieco MH; Cooper LZ
HPA-23 was used in a parallel, multiple dose study in patients with Centers for Disease Control (CDC)-defined AIDS. Sixteen patients were divided into four dosage groups, receiving 0.25, 0.5, 1.0, or 2.0 mg/kg HPA-23 respectively, by rapid IV infusion five days/week for eight weeks. Blood was collected before, at week
We have evaluated a new enzyme immunoassay (EIA) to measure IgG antibodies (Abs) to HIV in patients with AIDS, AIDS-related complex (ARC), AIDS contacts (AC), and low risk controls. Twenty-nine (94%) of 31 AIDS, 27 (96%) of 26 ARC, 12 (54%) of 22 AC, and 1 (2%) of 60 control patients were anti-HIV Ab positive by this
Ann Pathol. 1986;6(4-5):255-60. Unique Identifier : AIDSLINE MED/87128388
Coulaud JP; Thimossat P
The discovery in 1983 of the virus subsequently designated as HIV and its detection in several organs and lymphoid and others cells has led to greater knowledge of the clinical manifestations related to infection with the virus. Certain manifestations seem to be directly related to the viral infection. These are essen
Ann Pathol. 1986;6(4-5):266-70. Unique Identifier : AIDSLINE MED/87128390
Diebold J; Audouin J; Marche C; Le Tourneau A
The histopathological modifications of the lymph nodes are studied in patients at risk for AIDS, LAV positive, with the lymphadenopathy syndrome (LAS) or the ARC. Three different types are described: type IA, with predominantly a severe follicular hyperplasia, type IB with angiofollicular hyperplasia or Castleman dise
Ann Pathol. 1986;6(4-5):292-6. Unique Identifier : AIDSLINE MED/87128396
Capron F
The author presents a quick review of the pulmonary lesions due to ARC, mainly the pulmonary lymphoid hyperplasias. The most frequent pulmonary complications of the disease are summarised (opportunistic infections and Kaposi sarcoma) the practical conditions of their pathological diagnosis are illustrated.
Based on our experience, we would like to offer a few pragmatic suggestions for the practicing clinician. These recommendations are summarized in Tables 1 and 2. The first encounter with most patients gives the impression of either a dramatic acute infection, usually in the lungs, central nervous system, or gastrointe
AIDS is caused by a newly recognised virus (human immunodeficiency virus; HIV) which induces a profound defect in cellular immune function associated with increased susceptibility to opportunistic infections and certain malignancies. The clinical presentation of HIV ranges from asymptomatic infection to severe immunod
Cheng YC; Dutschman GE; Bastow KF; Sarngadharan MG; Ting RY
Using affinity purified human immunodeficiency virus (HIV) reverse transcriptase the reaction assay conditions were determined. The optimum incorporation of dTMP into the (rA)n(dT)10 template with HIV reverse transcriptase required 6 mM MgCl2 and 80 mM KCl. The template specificity of HIV reverse transcriptase is quit
We compared an indirect immunofluorescence assay (IFA) with a commercial enzyme-linked immunosorbent assay (ELISA) screening procedure for the detection of antibodies to the human immunodeficiency virus (HIV). The IFA assay was as sensitive and specific as the ELISA. No false results were observed with IFA on single t
The characteristics of primary (first) tests with three enzyme-linked immunosorbent assay (ELISA) kits for human immunodeficiency virus (HIV) antibody were determined. The three ELISAs were performed on 3,229, 3,130, and 685 specimens from high-risk individuals using the Litton (LT; Litton Bionetics Laboratory Product
Bender BS; Bohnsack JF; Sourlis SH; Frank MM; Quinn TC
The function of macrophage C3 receptors was assessed in vivo by measuring the clearance of C3-sensitized autologous erythrocytes in seven acquired immunodeficiency syndrome (AIDS) patients, eight healthy homosexual men, eight healthy heterosexual men, and four infected controls. Healthy heterosexual men had an initial
Immunofluorescence and immunoblot assays were conducted on 488 sera from patients with AIDS and clinically healthy individuals at risk for infection by the human immunodeficiency virus. Of these, 360 contained antiviral antibodies, and nearly all reacted with the envelope precursor glycoprotein gp160. Sera from 103 in
JAMA. 1987 Mar 13;257(10):1357-66. Unique Identifier : AIDSLINE MED/87141496
Francis DP; Chin J
Human immunodeficiency virus (HIV) is one of the most virulent infectious agents ever encountered. This virus, estimated to kill up to a half of those infected, has spread to more than 1 million Americans. There is no safe and effective treatment. Nor is there a vaccine. From our understanding of HIV transmission, fur
JAMA. 1987 Mar 13;257(10):1367-74. Unique Identifier : AIDSLINE MED/87141497
Kaplan LD; Wofsy CB; Volberding PA
Treatment of AIDS is multidisciplinary and often involves input from a number of medical subspecialties. Treatment of opportunistic infections and malignancies in AIDS is largely palliative in that these treatments do not reverse the underlying immunodeficiency. Investigational approaches to the treatment of this synd
Screening tests for antibodies to the human immunodeficiency virus (HIV), based on the indirect ELISA principle using viral preparations as antigen, yield a substantial number of false-positive and false-negative results. These failures are due to the lack of certain viral polypeptides or contaminating cellular polype
Nature. 1987 Mar 12-18;326(6109):200-3. Unique Identifier : AIDSLINE MED/87144641
Donahue RE; Johnson MM; Zon LI; Clark SC; Groopman JE
Viral infections are frequently associated with haematological disorders. Abnormalities including leukopenia, anaemia and thrombocytopenia are commonly observed in patients with the acquired immune deficiency syndrome (AIDS) or the AIDS-related complex (ARC). The underlying cause of these haematological abnormalities
One thousand sera shown to be reactive by one of two commercial enzyme linked immunosorbent assays (ELISA) for antibodies to the AIDS virus were referred to the NSW State Reference Laboratory for confirmatory assays. Each serum was retested by two commercial ELISA systems (Abbott and ENI), the ENI exclusionary H9 ELIS
Like many other viruses, human immunodeficiency virus (HIV) causes a broad array of host responses. Some persons mount an appropriate immune response after infection and remain asymptomatic, while others become progressively debilitated by the effects of the infection. Paradoxically, autoimmune disease can coexist wit
Proc Natl Acad Sci U S A. 1987 Mar;84(5):1434-8. Unique Identifier : AIDSLINE MED/87147288
Luciw PA; Cheng-Mayer C; Levy JA
Mutations were made by recombinant DNA techniques in an infectious molecular clone of the human immunodeficiency virus San Francisco isolate 2 (HIVSF2) [formerly the prototype isolate of the acquired immunodeficiency syndrome-associated retrovirus (ARV-2)]. The effect of these changes on the replicative and cytopathol
There is now general agreement that both ulcerative colitis and Crohn s disease predispose patients to the development of malignancy. Many controversies still remain concerning the incidence of this complication as well as the diagnostic approach to be taken with these patients. This article reviews the topic and exam
Azidothymidine and ribavirin both inhibit replication of human immunodeficiency virus in vitro and show promise of clinical utility in patients infected with this virus. In this study, the possible interactions of these drugs were examined in vitro, and a reproducible antagonism between azidothymidine and ribavirin wa
Science. 1987 Mar 20;235(4795):1501-4. Unique Identifier : AIDSLINE MED/87149083
Laurence J; Saunders A; Kulkosky J
Reverse transcriptase activity of the human immunodeficiency virus (HIV) was blocked in vitro by immunoglobulin G (IgG) derived from certain individuals infected with this retrovirus. A heterogeneous immune response for inhibition of enzyme function was noted. Catalytic activity was depressed by 50% or more with the u
The test sera from 50 patients treated with intravenous gammaglobulins (IVG) were examined for LAV/HTLV-III antibody by ELISA tests in order to evaluate the risk of transmission of LAV/HTLV-III virus via administration of IVG. The three ELISA-positive sera were negative for the antibody by both indirect immunofluoresc
Salvatierra O Jr; Melzer J; Vincenti F; Amend WJ Jr; Tomlanovich S; Potter D; Husing R; Garovoy M; Feduska NJ
DST provides excellent graft survival in one- and zero-haplotype-matched donor-recipient pairs as well as a trend towards improving graft survival in HLA-identical matches; serum creatinine levels are good in functioning grafts; Imuran coverage does appear to decrease DST sensitization to the blood donor in nonsensiti
Zaides VM; Berezin VE; Kliushnik SIu; Strokov AA; Marennikova SS
A system for serodiagnosis of infection with AIDS viruses by means of immune (western) blotting has been developed. The system has been found to be highly sensitive and suitable for expert serodiagnosis of AIDS disease and infection with human AIDS viruses.
Am J Med. 1987 Mar;82(3):456-62. Unique Identifier : AIDSLINE MED/87153412
Gelmann EP; Longo D; Lane HC; Fauci AS; Masur H; Wesley M; Preble OT; Jacob J; Steis R
Two clinical trials were conducted to assess the efficacy and safety of a combination chemotherapy regimen for the treatment of Kaposi s sarcoma in patients with the acquired immune deficiency syndrome (AIDS). Eighteen consecutive patients with disseminated Kaposi s sarcoma were treated with a six-drug regimen of doxo
Am J Med. 1987 Mar 23;82(3 Spec No):615-20. Unique Identifier : AIDSLINE MED/87153448
Kaplan LD; Wolfe PR; Volberding PA; Feorino P; Levy JA; Abrams DI; Kiprov D; Wong R; Kaufman L; Gottlieb MS
Forty-one homosexual men with the acquired immune deficiency syndrome (AIDS) or AIDS-related complex were treated with 0.5, 1.0, or 1.5 g of suramin weekly for up to six months. In no patient was evidence of symptomatic improvement or regression of Kaposi s sarcoma shown. Opportunistic infections developed in 16 patie
Am J Pathol. 1987 Mar;126(3):403-10. Unique Identifier : AIDSLINE MED/87153752
Vazeux R; Brousse N; Jarry A; Henin D; Marche C; Vedrenne C; Mikol J; Wolff M; Michon C; Rozenbaum W; et al
Human immunodeficiency virus (HIV) RNA and proteins were detected in the brains of several AIDS patients with subacute encephalitis, by in situ hybridization and immunohistology. The majority of infected cells were mononucleated and bore processes. Using single and double immunohistologic procedures, the authors ident
Am J Pathol. 1987 Mar;126(3):513-26. Unique Identifier : AIDSLINE MED/87153764
Chander P; Soni A; Suri A; Bhagwat R; Yoo J; Treser G
Renal tissues from two groups of patients with acquired immune deficiency syndrome (AIDS) were examined: Group A had severe proteinuria and varying degrees of renal insufficiency, designated AIDS-associated nephropathy (AAN), and Group B had no renal involvement. Control Group C consisted of patients with heroin-assoc
Ann Intern Med. 1987 Apr;106(4):546-9. Unique Identifier : AIDSLINE MED/87154820
Schneiderman DJ; Cello JP; Laing FC
Eight homosexual men with the acquired immunodeficiency syndrome (AIDS) presented with clinical, biochemical, and radiologic features of stenosis of the papilla of Vater and sclerosing cholangitis. This newly recognized complication of AIDS produces abdominal pain, nausea, and vomiting and may predispose patients to s
Patients with the acquired immunodeficiency syndrome (AIDS) die of overwhelming infections as a consequence of the destruction of the T4 subset of lymphocytes. Approaches to the treatment of AIDS have involved attempts to reestablish immune competence as well as treat opportunistic infections. The discovery of the hum
Peripheral blood lymphocyte subsets and the incidence of LAV/HTLV-III antibodies were studied in 63 patients with hemophilia A who had been transfused with a low dose regimen of commercial (U.S.A.) factor VIII concentrates. Five patients with hemophilia B were also included in this study. In hemophilia A patients a si
AIDS Res. 1986 Fall;2(4):343-8. Unique Identifier : AIDSLINE MED/87128382
Damsker B; Bottone EJ
Culture of the buffy coat layer of the peripheral blood of 14 AIDS patients demonstrated sustained mycobacteremia or fungemia: 11 with Mycobacterium avium-intracellulare, 2 with Cryptococcus neoformans, and one with Mycobacterium tuberculosis. The early detection of these agents prior to the onset of overt symptomatol
Ann Pathol. 1986;6(4-5):271-4. Unique Identifier : AIDSLINE MED/87128391
Audouin J; Le Tourneau A; Marche C; Diebold J
The authors describe the immunopathological findings in the different histopathological types. In type IA, the most important findings are disruption of the network of the intrafollicular dendritic cells, progressive atrophy of the mantle zone as shown with anti-delta antibody, the progressive diminution of the number
We tested the premise that measurement of interleukin 2 receptor (IL2R) and transferrin receptor (TR) can be used to assess proliferative responses to pokeweed mitogen (PWM) and tetanus toxoid (TT). Our study group consisted of patients with Human Immunodeficiency Virus (HIV) infection, including patients with acquire
Blanchard DK; Rodloff AC; Steward WE 2d; Hahn H; Friedman H
Previous reports have shown that Bacteroides fragilis may enhance the pathogenicity of coinfecting enterobacteriaceae by interfering with the host s immune response. With the present study, we have investigated the possible role of interferons (IFN) in mediating these effects. Mice injected with B. fragilis developed
Yoshida T; Matsui T; Kobayashi S; Harada S; Kurimura T; Hinuma Y; Yamamoto N
A new serological test, the gelatin particle agglutination (PA) test, was developed for the detection of antibody to human immunodeficiency virus (HIV). The sensitivity of the PA test was the same as that of enzyme-linked immunosorbent assay (ELISA) among 761 US and Japanese sera tested. However, false-positive cases
Asjo B; Ivhed I; Gidlund M; Fuerstenberg S; Fenyo EM; Nilsson K; Wigzell H
The monocytoid tumor cell line U-937 and five derived subclones were infected with the HTLV-IIIB isolate of the human immunodeficiency virus (HIV). Susceptibility to infection and sensitivity to the cytopathic effects correlated with the expression of the T4 antigen on the cell surface. On the basis of these character
Jonckheer T; Levy J; Van de Perre P; Thiry L; Henrivaux P; Sacre JP; Schepens G; Mees N; Dab I; Taelman H; et al
From December 1982 to June 1985, we diagnosed LAV/HTLV-III infection in 16 children of African origin living in Belgium or referred to one of the hospitals participating in this study. Diagnosis was proven in seven of them by isolation of virus of the LAV/HTLV-III group. In the ni
Howard LC; Paterson-Brown S; Weber JN; Chan ST; Harris JR; Glazer G
Two cases of squamous carcinoma of the anus in white homosexual men aged 36 and 47 years are reported, each with a short history of rapidly enlarging perianal lesions. Immunological studies showed that both men had pronounced T helper lymphocyte depletion, and antibody to human T cell lymphotropic virus type III (HTLV
Kaplan MH; Sadick N; McNutt NS; Meltzer M; Sarngadharan MG; Pahwa S
We present a review of the spectrum of human T-lymphotropic virus type III (HTLV-III) infection with particular emphasis on cutaneous manifestations in 217 patients. Correlations are made with immunodeficiency as measured by absolute T-helper cell number. A classification is presented of these dermatologic findings.
Katner HP; deShazo RD; Pankey GA; Andes WA; Daul CB; Cortez L; Dalovisio J; Bozelka B
Patients with the acquired immune deficiency syndrome (AIDS) have depressed cell-mediated immunity partially explained by a depletion of helper-inducer T-lymphocytes. We questioned if the remaining elements of the mononuclear cell (MNC) population also played a part in the immunologic abnormalities noted. We therefore
The therapy of Pneumocystis carinii (PC) pneumonia is often unsuccessful, particularly in patients with acquired immune deficiency syndrome (AIDS). Because of difficulties in growing the organism in vitro or obtaining purified organisms, current treatment choices have been made with little information on the metabolic
Interleukin 1 (IL-1) and the human retrovirus HTLV-III/LAV represent two distinct molecular and biological constituents that are apparently shared by both the immune and central nervous systems. IL-1 is a cytokine produced principally by monocytes of the immune system and glial cells of brain in situ or in vitro. HTLV
Presse Med. 1987 Feb 28;16(7):346-8. Unique Identifier : AIDSLINE MED/87146981
Piette AM; Tusseau F; Chapman A
Primary manifestations of HIV infection may present as a mononucleosis-like syndrome. Cases have also been reported where it presents with symptoms of encephalitis, meningitis or acute polyneuropathy. When no cause is found for such clinical symptoms, they should suggest the possibility of primary HIV infection even i
We describe an unusual type of cytopathology in which uninfected CD4+ (helper/inducer) cells (cells expressing the human leukocyte antigen CD4) interact with cells persistently infected with the human immunodeficiency virus (HIV). Prior antigenic stimulation was not required, since CD4+ cells taken either from healthy
AIDS Res. 1986 Fall;2(4):299-308. Unique Identifier : AIDSLINE MED/87128377
Kotler DP; Culpepper-Morgan JA; Tierney AR; Klein EB
Disseminated cytomegalovirus ( CMV ) infection is a common complication of the acquired immunodeficiency syndrome (AIDS) and contributes significantly to its morbidity and mortality. Dihydroxypropoxymethyl guanine, DHPG, is an
Multiple markers were used to count Langerhans cells in the cervix. In the normal cervix, thymocyte antigen (T6) and adenosine triphosphatase (ATPase) demonstrated the largest population of Langerhans cells. MHC Class II positive cells were equivalent to 60%, and S100 positive cells were equivalent to 35% of T6 or A
Lymphocyte phenotypes in cervical mucosa were studied using a panel of monoclonal antibodies. T lymphocytes were predominant both within the epithelium and in the subepithelial stroma. In the normal cervix, both the T4+ (helper/inducer) and T8+ (suppressor/cytotoxic) subsets were present in a ratio similar to that in
Alonso ML; Richardson ME; Metroka CE; Mouradian JA; Koduru PR; Filippa DA; Chaganti RS
Cytogenetic studies were performed on direct and 24-hour culture preparations of eight lymph node biopsies from seven patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC)-associated lymphadenopathy in whom histological evidence of lymphoma was not detected. Three of these seven had chr
Specific antiviral chemotherapy now has an established role in the treatment of many virus infections, particularly those caused by herpesviruses. This change is one of the major medical developments of the last decade. There is reason to believe that further advances will occur, and we can look forward to a range of
Can J Ophthalmol. 1987 Feb;22(1):48-52. Unique Identifier : AIDSLINE MED/87130286
Macdonald EA
Asymptomatic retinal lesions were found on annual ophthalmic examination in a 38-year-old homosexual man with the acquired immune deficiency syndrome (AIDS). The lesions were compatible with cytomegalovirus retinitis and progressed. Treatment with 9-(1,3-dihydroxy-2-propoxymethyl)g
Robertson SJ; Lowman JT; Grufferman S; Kostyu D; van der Horst CM; Matthews TJ; Borowitz MJ; Bigner SH
A three to sevenfold increased risk of Hodgkin s disease has been noted in families of patients. We report the first family in which all four of a four member sibship had Hodgkin s disease. In these four sibling cases, we were able to explore markers of infectious etiologic factors by measuring antibodies to Epstein-B
Cancer Res. 1987 Mar 1;47(5):1199-220. Unique Identifier : AIDSLINE MED/87130668
Duesberg PH
Retroviruses (without transforming genes) are thought to cause leukemias and other cancers in animals and humans because they were originally isolated from those diseases and because experimental infections of newborns may induce leukemias with probabilities of 0 to 90%. According to this hypothesis viral cancers shou
Cancer Res. 1987 Mar 15;47(6):1582-7. Unique Identifier : AIDSLINE MED/87130729
van Zoelen EJ; van Rooijen MA; van Oostwaard TM; de Laat SW
Cellular transformation of normal rat kidney (NRK) cells by simian sarcoma virus (SSV) results in a complete loss of the cellular requirement of externally added polypeptide growth factors for proliferation. Moreover, SSV-transformed NRK cells have a strongly reduced ability to bind both external platelet-derived grow
Morgello S; Cho ES; Nielsen S; Devinsky O; Petito CK
The pathology of cytomegalovirus ( CMV ) encephalitis was studied at autopsy in thirty patients with acquired immunodeficiency syndrome. Lesions could be segregated into five major categories: microglial nodules, isolated inclu
By testing serum samples taken between 1980 and 1984 from men attending a department of sexually transmitted diseases, it was shown that antibodies to human immunodeficiency virus (HIV) first appeared in 1981. Homosexual men were significantly more likely to have antibodies to HIV and to
Peripheral blood lymphocytes of patients with AIDS are generally anergic to stimulation by lectins or by alloantigens. We have succeeded in demonstrating that the lymphocytes of six AIDS patients, with histories of herpes simplex virus (HSV)-induced genital, anal and/or oral lesions, retained functional specificity wi
Human immunodeficiency virus (HIV) was isolated from a Japanese hemophilia B patient with AIDS. This isolate, HIV[GUN-1], was infectious to several mature T-cell lines. Proteins with apparent molecular weights of 160, 55 and 25 kilodaltons were detected. Restriction enzyme cleavage patterns of the proviral genome indi
Nath N; Wunderlich C; Darr FW 2d; Douglas DK; Dodd RY
Blood samples from 98 asymptomatic volunteer blood donors, including 55 that were reactive for antibodies to human immunodeficiency virus (HIV) in Western blot (WB) assay, were tested for levels of immunoglobulin G (IgG), IgM, and titer of antibodies to HIV, cytomegalovirus , and he
Between January 1982 and May 1986 279 biopsy specimens from 82 patients with acquired immune deficiency syndrome (AIDS) were examined. A wide variety of infectious conditions were diagnosed, the commonest being Pneumocystis pneumonia (n = 36), cytomegalovirus (n = 21), a variety of
Autopsy results on twenty-four patients with acquired immunodeficiency syndrome (AIDS) and Kaposi s sarcoma were reviewed. At postmortem, 29% of patients had evidence of visceral Kaposi s sarcoma without skin lesions. The most common sites for visceral involvement with Kaposi s sarcoma were as follows: lung (37%), gas
Lundin K; Nygren A; Arthur LO; Robey WG; Morein B; Ramstedt U; Gidlund M; Wigzell H
The HIV (HTLV-III) envelope glycoprotein, Gp120, was isolated from virus-infected tissue culture cells using affinity chromatography. A radioimmunoassay was developed to determine the degree of iodinated Gp120 to target CD4+ (T4+) cells. 125I-Gp120 could be shown to selectively bind to CD4+ cells only. The Gp120 remai
We report the detection of human T cell leukemia virus type I (HTLV-I) and human immunodeficiency virus (HIV) in the cultured lymphocytes of a 45-year-old Zairian man with AIDS. HIV was successfully isolated and analyzed by SDS-PAGE and competition radioimmunoassay. However, by the culture techniques used, HTLV-I coul
Mori K; Sabe H; Siomi H; Iino T; Tanaka A; Takeuchi K; Hirayoshi K; Hatanaka M
We isolated the full length provirus of human T cell leukaemia virus type I (HTLV-I) from MT-2, a lymphoid cell line producing HTLV-I. In three non-lymphoid cell lines (COS7, human osteosarcoma HOS cells, and HeLa) this provirus expressed a trans-acting activity after co-transfection with a recombinant plasmid carryin
Type D retroviruses have recently been shown to induce a wasting syndrome with associated lymphadenopathy, thymic atrophy and transient decreased peripheral blood lymphocyte blastogenic responsiveness in juvenile macaque monkeys. The replication in vitro of D/New England virus was assessed in various lymphocyte subpop
J Med Virol. 1987 Feb;21(2):123-35. Unique Identifier : AIDSLINE MED/87140000
Nerurkar LS; Biggar RJ; Goedert JJ; Wallen W; Becker P; West F; Tzan N; Traub R; Lee YJ; Botelar W; et al
Healthy homosexual men between the ages of 21 and 65 years, from the Washington, DC (n = 162), and New York City (n = 89) areas, were studied for antibodies in the serum against cytomegalovirus ( CMV ), herpes simplex virus (HS
The viral core proteins (p15, p26, p11, and p9) of equine infectious anemia virus (EIAV) (Wyoming strain) were purified by reverse-phase high-pressure liquid chromatography. Each purified protein was analyzed for amino acid content, N-terminal amino acid sequence, C-terminal amino acid sequence, and phosphoamino acid
Nature. 1987 Feb 26-Mar 4;325(6107):773-8. Unique Identifier : AIDSLINE MED/87144582
Mitsuya H; Broder S
The retrovirus that causes AIDS has revealed enough of its life history for a variety of therapeutic strategies to be apparent. Some of these are suitable for immediate application in clinical trials or have already yielded positive results in some patients.
Opportunistic infections (OI) were diagnosed by histology and culture of biopsy and autopsy material in 15 children with the acquired immune deficiency syndrome (AIDS). The opportunistic pathogens included Pneumocystic carinii, Toxoplasma gondii, Candida species, Aspergillus species, Mycobacterium avium-intracellulare
By mid-fall of 1986 the look-back process conducted by blood banks belonging to the American Association of Blood Banks was about 50 percent complete. Over one-half of the traced recipients had died; 15 percent were alive and negative for antibodies to the human immunodeficiency virus and 16 percent alive but had sero
A confidential self-administered questionnaire was given to all blood donors prior to donation (n = 95,917). The questionnaire describes groups at increased risk of acquired immunodeficiency syndrome (AIDS) and requires the donor to designate his blood either for laboratory purposes or for transfusion. In a previous c
Ujhelyi E; Fust G; Mihaleczky G; Krall G; Zimonyi I; Nagy K; Mayer V; Hollan SR
Nine serial three-fold dilutions (1:1 to 1:6561) were prepared from 18 sera obtained from hemophiliacs confirmed to have antibodies to the human immunodeficiency virus. The dilutions were tested with five different commercial enzyme immunoassay kits and twelve sera were retested 5 to 7 months later by different lots o
Thayer RM; Power MD; Bryant ML; Gardner MB; Barr PJ; Luciw PA
Simian acquired immunodeficiency syndrome (SAIDS) in macaque monkeys is caused by type D retroviruses; three independent virus isolates are identified as SRV-1 (SAIDS retrovirus-serotype 1), SRV-2, and MPMV (Mason- Pfizer monkey virus). Virions from these three isolates hav
Helweg-Larsen S; Jakobsen J; Boesen F; Arlien-Soborg P
A survey of the literature of neurological manifestations associated with the acquired immune deficiency syndrome (AIDS) shows a broad disease spectrum affecting approximately one third of the patients in large hospital series. The complications include focal cerebral lesions caused by abscesses, lymphomas, leucoencep
To investigate the relationships among cytomegalovirus infection, sexual behavior, human immunodeficiency virus (HIV) seropositivity, and indexes of cellular immunity, 180 homosexual men and 26 heterosexual men were studied. Among the homosexual men, cytomegalovirus seropositivity
Am J Med. 1987 Mar 23;82(3 Spec No):649-54. Unique Identifier : AIDSLINE MED/87153457
Cappell MS; Chow J
A patient with HTLV-I-associated adult T cell lymphoma presented like a patient with the acquired immune deficiency syndrome (AIDS) with peripheral lymphadenopathy, profuse diarrhea, weight loss, night sweats, and multiple opportunistic infections. Infections included cytomegalovirus
Am J Ophthalmol. 1987 Mar 15;103(3 Pt 1):316-20. Unique Identifier : AIDSLINE MED/87153661
Henderly DE; Freeman WR; Smith RE; Causey D; Rao NA
We studied eight patients in whom cytomegalovirus retinitis was an initial manifestation of AIDS. Six of these patients had cytomegalovirus retinitis alone at the time of diagnosis and two patients had simultaneous cytomegalovirus retinitis with other AIDS associated diseases (Kapo
Am J Pathol. 1987 Feb;126(2):199-207. Unique Identifier : AIDSLINE MED/87153732
Ringler DJ; Hancock WW; King NW; Letvin NL; Daniel MD; Desrosiers RC; Murphy GF
A T-cell tropic retrovirus, simian immunodeficiency virus (SIV), has recently been isolated from immunodeficient rhesus monkeys. This virus has remarkable similarities to human immunodeficiency virus (HIV), the etiologic agent of acquired immunodeficiency syndrome. Subsequent studies of simian infection with SIV have
To clarify risk factors for infection with the human immunodeficiency virus (HIV) we selected at random 785 homosexual men who had participated in studies of hepatitis B in San Francisco in 1978-80 for a follow-up study of the acquired immunodeficiency syndrome. Although most had not been contacted in over five years,
Nine patients with inflammatory demyelinating polyneuropathies (IDP) were found to have human T-cell lymphotropic virus type III (HTLV-III) infection. The 8 men, 6 of whom were homosexual, and 1 woman, a former intravenous drug user, presented with progressive weakness. Two had lymphadenopathy but all were otherwise a
Tropical spastic paraparesis (TSP) is a common myeloneuropathy with primary and predominant involvement of the pyramidal tract and minimal sensory loss. The epidemic form of TSP is related to toxic nutritional factors, but the endemic form occurs in clusters in tropical areas, especially in
Kubonishi I; Daibata M; Yano S; Fujishita M; Taguchi H; Miyoshi I
A 41-year-old woman presented with a gastric lymphoma. A total gastrectomy was performed, and the tumor was found to consist of T cells of the helper/inducer (E+, Leu-1+, Leu-2a-, Leu-3a+) phenotype. The patient was seropositive for T-cell leukemia virus type I, and the tumor cells contained the proviral genome.
Kostianovsky M; Orenstein JM; Schaff Z; Grimley PM
Two types of cytomembranous inclusions commonly occur in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related conditions: tubuloreticular inclusions (TRI) and cylindrical confronting cisternae (CCC). CLinical and experimental studies both indicate that the occurrence of TRI in AIDS, systemic lupus
The ultrastructure of cytomegalovirus infection of glial cells in an area of demyelination in the brain of a patient with subacute encephalopathy associated with acquired immunodeficiency syndrome is described. By comparison with the lung of the same patient, the cytomegalovirus-in
We evaluated the sensitivity of bronchoscopy for the diagnosis of Pneumocystis carinii and cytomegalovirus pulmonary infections in patients with acquired immunodeficiency syndrome. The antemortem and postmortem diagnoses were compared in 36 patients who underwent fiberoptic broncho
This is a case report of an Epstein-Barr virus-induced polyclonal lymphoproliferative disorder in a presumably immunocompromised patient with Western blot-confirmed antibodies to human immunodeficiency virus. Postmortem examination revealed a diffuse lymphoplasmacytic infiltrate with prominent numbers of immunoblasts
Biochem Biophys Res Commun. 1987 Feb 27;143(1):248-51. Unique Identifier : AIDSLINE MED/87156753
Pincus MR; Carty RP; Chen J; Murphy RB
A homology has been found between an octapeptide involved in attachment of the human immunodeficiency virus to helper/inducer T cells and an octapeptide segment of bovine pancreatic ribonuclease A. This segment (residues 19-26) contains the sites for subtilisin cleavage of this enzyme into the S-peptide and S-protein.
Cancer. 1987 Mar 15;59(6):1059-62. Unique Identifier : AIDSLINE MED/87130550
Tamura K; Makino S; Araki Y; Imamura T; Seita M
Adult T-cell leukemia (ATL) is one of the most difficult diseases to treat because of severe underlying immune deficiency and metabolic disturbance. Interferon has potent antiviral, antiproliferative, and immunomodulating properties, and therefore, this may be a good agent to treat such immune deficient patients with
Cancer. 1987 Mar 15;59(6):1187-91. Unique Identifier : AIDSLINE MED/87130574
Kiyokawa T; Yamaguchi K; Takeya M; Takahashi K; Watanabe T; Matsumoto T; Lee SY; Takatsuki K
Eighteen autopsy cases of adult T-cell leukemia (ATL) were investigated clinicopathologically. Thirteen of the patients had hypercalcemia during their clinical course. Nine of the thirteen had a high level of serum calcium at the terminal stage, even after extensive chemotherapy. Microscopic examination of the bone re
Cocultivation of spleen cells, lymph node cells, and thymocytes of female Wistar-King-Aptekman rats with short-term cultured male adult T cell leukemia (ATL) cells in the presence of 5-bromo-2 -deoxyuridine (BudR) resulted in the establishment of rat lymphoid cell lines, TARS-1, TARL-2, and TART-1. Cytogenic analysis
Monoclonal antibodies against lymphoid cell-associated antigens have contributed substantially to our understanding of cutaneous lymphomas. The distribution and function of the most important T- and B-cell antigens are summarized and their expression on cutaneous lymphomas is discussed. Monoclonal antibodies can provi
Tobinai K; Minato K; Shimoyama M; Kawatani T; Kurimura T
One thousand six hundred and seventy-four blood samples drawn between January 1980 and April 1986 from 1454 Japanese, including 251 leukemia, 409 lymphoma, 76 adult T-cell leukemia and 25 benign lymphadenitis patients, were tested for antibodies to HIV and HTLV-I. No patient with lymphadenitis or lymphoma associated w
Noda Y; Ishikawa K; Sasagawa A; Honjo S; Mori S; Tsujimoto H; Hayami M
Studies were made of the hematologic features of 23 adult African green monkeys (Cercopithecus aethiops) naturally infected with simian T-cell leukemia virus (STLV), which is closely related to human T-cell leukemia virus type I. None of the STLV-infected monkeys showed any clinical signs, but their absolute lymphocyt
Four adults form four separate households were found to have simultaneous retroviral infections with human T cell leukemia virus type I (HTLV-I) and human immunodeficiency virus (HIV). These individuals were seropositive for the HTLV-I env transmembrane protein p21E, and all had antibodies to the HTLV-I core polypepti
Lancet. 1987 Feb 28;1(8531):492-4. Unique Identifier : AIDSLINE MED/87143307
Colebunders R; Mann JM; Francis H; Bila K; Izaley L; Kakonde N; Kabasele K; Ifoto L; Nzilambi N; Quinn TC; et al
A provisional clinical case-definition for acquired immunodeficiency syndrome (AIDS) developed by the World Health Organisation (WHO) for use in Africa was tested on 174 inpatients at Mama Yemo Hospital, Kinshasa, Zaire . In this hospital population with a 34% infection rate of hum
To investigate the possibility that the recently recognised syndrome, leukaemia of large granular lymphocytes, could be associated with human T-cell leukaemia/lymphoma virus type I (HTLV-I), sera from 12 patients with this type of leukaemia were tested by the use of western-blot techniques for IgG antibodies to protei
Lancet. 1987 Mar 14;1(8533):612-5. Unique Identifier : AIDSLINE MED/87143403
Vittecoq D; May T; Roue RT; Stern M; Mayaud C; Chavanet P; Borsa F; Jeantils P; Armengaud M; Modai J; et al
Seventeen Caucasian patients with acquired immunodeficiency syndrome (AIDS) contracted after long stays in Africa are reported. Central Africa was concerned in all cases. Men are particularly exposed to AIDS whatever their occupation. This study suggests that the risk of contracting AIDS in Africa is high; the transmi
Ann Neurol. 1987 Feb;21(2):117-22. Unique Identifier : AIDSLINE MED/87155221
Osame M; Matsumoto M; Usuku K; Izumo S; Ijichi N; Amitani H; Tara M; Igata A
Six adult patients had a chronic progressive myelopathy that possessed the following features: high antibody titers to human T-lymphotropic virus type I (HTLV-I) in serum and cerebrospinal fluid (CSF); predominantly upper motor neuron disorder, symmetrical, with mild sensory and bladder disturbances; and presence of a
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