Subacute encephalomyelitis of AIDS and its relation to HTLV-III infection. NLM AIDSLINE Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

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Subacute encephalomyelitis of AIDS and its relation to HTLV-III infection.

Neurology. 1987 Apr;37(4):562-9. Unique Identifier : AIDSLINE MED/87173554
de la Monte SM; Ho DD; Schooley RT; Hirsch MS; Richardson EP Jr

Abstract: Subacute encephalitis, characterized by demyelination, gliosis of the gray and white matter, focal necrosis, microglial nodules, atypical oligodendrocyte nuclei, and multinucleation of cells, was present in 27 of 30 (90%) autopsied patients with acquired immune deficiency syndrome (AIDS) or AIDS-related complex. Subacute encephalitis was mainly distributed in the frontal (58%) and temporal (69%) lobes, basal ganglia (77%), amygdala (80%), and hippocampus (64%). Ten (37%) with moderate or severe subacute encephalitis were demented; 82% with mild subacute encephalitis had no recognized neurologic disorder. Human T-lymphotropic virus type III (HTLV-III) was isolated from neural tissue or CSF in 11 of 13 patients, 10 with subacute encephalitis, and 1 without CNS lesions. We conclude that subacute encephalitis is common in AIDS patients and is most likely caused by CNS infection with HTLV-III.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult Aged Brain/*PATHOLOGY Child, Preschool Dementia/ETIOLOGY/PATHOLOGY Encephalomyelitis/*ETIOLOGY/PATHOLOGY Female Gliosis/PATHOLOGY Human Male Middle Age Peripheral Nerves/PATHOLOGY Spinal Cord/PATHOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcomplicationsadultagedbrain/KWDpathologychild,preschooldementia/etiology/pathologyencephalomyelitis/KWDetiology/pathologyfemalegliosis/pathologyhumanmalemiddleageperipheralnerves/pathologyspinalcord/pathologyjournalarticle
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M8770277

Copyright © 1987 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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